amitriptyline has been researched along with mexiletine in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (4.76) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Strassburg, CP; Tukey, RH | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY | 1 |
| Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P | 1 |
| Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| García-Mera, X; González-Díaz, H; Prado-Prado, FJ | 1 |
| Sen, S; Sinha, N | 1 |
| Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Nattel, S | 1 |
| Clifford, DB; Cohen, B; Dal Pan, GJ; Ellis, RJ; Hall, CD; Kieburtz, K; Marra, CM; Max, MB; McKendall, R; Simpson, D; Singer, E; Tucker, T; Yiannoutsos, C | 1 |
| Bräu, ME; Dreimann, M; Hempelmann, G; Olschewski, A; Vogel, W | 1 |
| Lein, B | 1 |
| Schuppert, F; Tiesmeier, J; Warnecke, H | 1 |
| Ishida, T; Kamei, C; Kanai, Y; Takeda, Y; Tanimoto-Mori, S; Toide, K; Tsutsui, R; Watanabe, S | 1 |
| Clouse, AK; Eisennagel, SH; Jugus, MJ; Laping, NJ; Thorneloe, KS; Westfall, TD | 1 |
| Aoki, T; Enomoto, R; Matsuoka, N; Shimoshige, Y; Tsukamoto, M | 1 |
2 review(s) available for amitriptyline and mexiletine
| Article | Year |
|---|---|
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic | 2000 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for amitriptyline and mexiletine
| Article | Year |
|---|---|
A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team.
Topics: Adrenergic Uptake Inhibitors; Adult; Amitriptyline; Anti-Arrhythmia Agents; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; HIV Infections; Humans; Male; Mexiletine; Neuritis; Pain; Peripheral Nerves | 1998 |
18 other study(ies) available for amitriptyline and mexiletine
| Article | Year |
|---|---|
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution | 2004 |
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties | 2004 |
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration | 2004 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics | 2010 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Relationship between use-dependent effects of antiarrhythmic drugs on conduction and Vmax in canine cardiac Purkinje fibers.
Topics: Action Potentials; Amitriptyline; Anesthesia, Local; Animals; Anti-Arrhythmia Agents; Dogs; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiology; Heart Conduction System; Kinetics; Lidocaine; Mexiletine; Microelectrodes; Procainamide; Purkinje Fibers | 1987 |
Effect of drugs used for neuropathic pain management on tetrodotoxin-resistant Na(+) currents in rat sensory neurons.
Topics: Amitriptyline; Analgesics; Anesthetics, Local; Animals; Cells, Cultured; Diethylcarbamazine; Drug Interactions; Electric Stimulation; Lidocaine; Memantine; Membrane Potentials; Mexiletine; Neurons, Afferent; Patch-Clamp Techniques; Rats; Rats, Wistar; Sodium Channel Blockers; Sodium Channels; Tetrodotoxin | 2001 |
Potential therapy for painful neuropathy.
Topics: Acupuncture Therapy; Amitriptyline; HIV Infections; Humans; Mexiletine; Nerve Growth Factors; Pain; Pain Management; Peripheral Nervous System Diseases | 1995 |
[An uncommon cause of recurrent abdominal pain in a 63-year-old obese woman].
Topics: Abdominal Pain; Adiposis Dolorosa; Amitriptyline; Analgesics, Non-Narcotic; Diagnosis, Differential; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Magnetic Resonance Imaging; Mexiletine; Middle Aged; Obesity; Recurrence; Treatment Outcome | 2006 |
Studies on somnolence in the daytime caused by drugs used for neuropathic pain.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Male; Mexiletine; Pyrazines; Pyridines; Rats; Rats, Sprague-Dawley; Sleep; TRPV Cation Channels | 2008 |
Voltage-gated Na+ channel blockers reduce functional bladder capacity in the conscious spontaneously hypertensive rat.
Topics: Amitriptyline; Animals; Carbamazepine; Female; Lamotrigine; Mexiletine; Rats; Rats, Inbred SHR; Receptors, Muscarinic; Sodium Channel Blockers; Sodium Channels; Triazines; Urinary Bladder, Overactive; Urodynamics | 2012 |
New index of pain triggered by spinal activation of voltage-dependent sodium channels.
Topics: Amitriptyline; Animals; gamma-Aminobutyric Acid; Injections, Spinal; Lidocaine; Male; Mexiletine; Mice; Mice, Inbred ICR; Morphine; Nociceptive Pain; Pain Management; Pain Measurement; Pregabalin; Spine; Voltage-Gated Sodium Channel Agonists; Voltage-Gated Sodium Channels | 2013 |