amitriptyline and metoprolol

amitriptyline has been researched along with metoprolol in 35 studies

Research

Studies (35)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (11.43)	18.7374
1990's	0 (0.00)	18.2507
2000's	16 (45.71)	29.6817
2010's	14 (40.00)	24.3611
2020's	1 (2.86)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Acevedo, O; Dasararaju, G; Devadasan, V; Halakova, D; Jayaprakash, V; Kovacikova, L; Mohd Siddique, MU; Mondal, SK; Prnova, MS; Shilkar, D; Stefek, M; Thakur, A; Yasmin, S	1
Kellhammer, U; Pfaffenrath, V; Pöllmann, W	1
Birgersson, C; Ericsson, O; Göransson, M; Henthorn, T; Sjöqvist, F; Spina, E; von Bahr, C	1
Hutt, HJ; Kirch, W; Kitteringham, NR; Mutschler, E; Ohnhaus, EE; Spahn, H	1
Brosi, K; Croissant, B; Hermann, D; Mann, K	1
Braathen, P; Molden, E	1
Frat, JP; Robert, R; Rouffineau, J; Veinstein, A	1
Baysal, T; Cimen, D; Doğan, M; Elmas, S; Karaaslan, S; Oran, B	1
Franke, JP; Hendriks, G; Uges, DR	1
Martínez-Ramírez, JA; Peters, FT; Voigt, K	1
Martínez-Ramírez, JA; Peters, FT; Walther, G	1
Eren Cevik, S; Guneysel, O; Tasyurek, T	1
Basol, N; Erbas, O	1
Martínez-Ramírez, JA; Peters, FT; Strien, J; Walther, G	1
May, A	1

Reviews

2 review(s) available for amitriptyline and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Hints on Diagnosing and Treating Headache. Deutsches Arzteblatt international, 2018, 04-27, Volume: 115, Issue:17 Topics: Amitriptyline; Analgesics, Non-Narcotic; Antihypertensive Agents; Headache; Humans; Metoprolol; Migraine Disorders; Propranolol; Research Design; Tension-Type Headache; Trigeminal Autonomic Cephalalgias	2018

Other Studies

33 other study(ies) available for amitriptyline and metoprolol

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability. Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7 Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids. Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20 Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives. European journal of medicinal chemistry, 2021, Nov-05, Volume: 223 Topics: Aldehyde Reductase; Animals; Caco-2 Cells; Catalytic Domain; Dogs; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Madin Darby Canine Kidney Cells; Male; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Rats, Wistar; Structure-Activity Relationship; Thiazolidinediones	2021
Combination headache: practical experience with a combination of a beta-blocker and an antidepressive. Cephalalgia : an international journal of headache, 1986, Volume: 6 Suppl 5 Topics: Adult; Amitriptyline; Cluster Headache; Drug Therapy, Combination; Female; Headache; Humans; Male; Metoprolol; Middle Aged; Migraine Disorders; Propranolol	1986
Inhibition of desmethylimipramine 2-hydroxylation by drugs in human liver microsomes. Biochemical pharmacology, 1985, Jul-15, Volume: 34, Issue:14 Topics: Amitriptyline; Antipyrine; Desipramine; Humans; Hydroxylation; In Vitro Techniques; Kinetics; Metoprolol; Microsomes, Liver; Theophylline	1985
Interaction between the beta-adrenoceptor blockers metoprolol and atenolol with amitriptyline and their effects on oxidative liver metabolism. British journal of clinical pharmacology, 1984, Volume: 17 Suppl 1 Topics: Adult; Amitriptyline; Antipyrine; Atenolol; Double-Blind Method; Drug Interactions; Female; Humans; Hydrocortisone; Kinetics; Liver; Male; Metoprolol; Oxidation-Reduction; Random Allocation	1984
[Drug-induced headache and pain reduction medication with amitriptyline in an 11-year old pupil]. Der Nervenarzt, 2004, Volume: 75, Issue:5 Topics: Amitriptyline; Analgesics; Antihypertensive Agents; Aspirin; Child; Dipyrone; Headache Disorders; Humans; Ibuprofen; Male; Metoprolol; Migraine Disorders; Students; Treatment Outcome	2004
Celecoxib is often combined with cytochrome P450 2D6 substrates in general clinical practice. Clinical pharmacology and therapeutics, 2005, Volume: 78, Issue:1 Topics: Amitriptyline; Celecoxib; Codeine; Computer Communication Networks; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Education, Pharmacy; Humans; Metoprolol; Norway; Pharmaceutical Services; Pharmacists; Practice Patterns, Physicians'; Pyrazoles; Sulfonamides; Time Factors	2005
Protective effect of medication bezoar after a massive beta-blocker, digoxin, and amitriptyline poisoning. Clinical toxicology (Philadelphia, Pa.), 2005, Volume: 43, Issue:5 Topics: Administration, Oral; Adult; Amitriptyline; Bezoars; Charcoal; Digoxin; Emergency Medical Services; Female; Gastric Lavage; Gastroscopy; Hospitalization; Humans; Intensive Care Units; Metoprolol; Psychiatric Department, Hospital; Radiography; Self Administration; Stomach; Vomiting	2005
Beta-blocker treatment in an adolescent with amitriptyline intoxication. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2007, Volume: 7, Issue:3 Topics: Adolescent; Adrenergic beta-Antagonists; Amitriptyline; Antidepressive Agents, Tricyclic; Coma; Diagnosis, Differential; Electrocardiography; Emergency Treatment; Female; Humans; Infusions, Intravenous; Metoprolol; Suicide, Attempted; Tachycardia, Ventricular	2007
New practical algorithm for modelling analyte recovery in bioanalytical reversed phase and mixed-mode solid phase extraction. Journal of pharmaceutical and biomedical analysis, 2008, Sep-10, Volume: 48, Issue:1 Topics: Acetanilides; Algorithms; Amitriptyline; Chromatography, High Pressure Liquid; Humans; Isomerism; Metoprolol; Pharmaceutical Preparations; Pseudoephedrine; Reference Standards; Reproducibility of Results; Solid Phase Extraction	2008
Studies on the metabolism of five model drugs by fungi colonizing cadavers using LC-ESI-MS/MS and GC-MS analysis. Analytical and bioanalytical chemistry, 2012, Volume: 404, Issue:5 Topics: Absidia; Amitriptyline; Aspergillus; Biotransformation; Cadaver; Chromatography, Liquid; Gas Chromatography-Mass Spectrometry; Gliocladium; Hydroxylation; Methylation; Metoprolol; Mianserin; Mirtazapine; Mortierella; Oxidation-Reduction; Pharmaceutical Preparations; Promethazine; Pyridines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Zolpidem	2012
Studies on drug metabolism by fungi colonizing decomposing human cadavers. Part II: biotransformation of five model drugs by fungi isolated from post-mortem material. Drug testing and analysis, 2015, Volume: 7, Issue:4 Topics: Amitriptyline; Biotransformation; Cadaver; Fungi; Humans; Metoprolol; Mianserin; Mirtazapine; Promethazine; Pyridines; Zolpidem	2015
Intralipid emulsion treatment as an antidote in lipophilic drug intoxications. The American journal of emergency medicine, 2014, Volume: 32, Issue:9 Topics: Adolescent; Adult; Alprazolam; Amitriptyline; Antidotes; Blood Pressure; Dibenzothiazepines; Drug Overdose; Fat Emulsions, Intravenous; Female; Fluoxetine; Glasgow Coma Scale; Heart Rate; Humans; Lamotrigine; Lipid Metabolism; Male; Metoprolol; Middle Aged; Nifedipine; Quetiapine Fumarate; Triazines; Young Adult	2014
The effects of diltiazem and metoprolol in QTc prolongation due to amitriptyline intoxication. Human & experimental toxicology, 2016, Volume: 35, Issue:1 Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Cardiovascular Agents; Diltiazem; Metoprolol; Rats	2016
Search for fungi-specific metabolites of four model drugs in postmortem blood as potential indicators of postmortem fungal metabolism. Forensic science international, 2016, Volume: 262 Topics: Aged; Amitriptyline; Biotransformation; Cardiovascular Agents; Central Nervous System Agents; Chromatography, Liquid; Female; Fungi; Humans; Male; Metoprolol; Mianserin; Middle Aged; Mirtazapine; Postmortem Changes; Pyridines; Tandem Mass Spectrometry; Zolpidem	2016