Compounds > amitriptyline

amitriptyline and fluorouracil

amitriptyline has been researched along with fluorouracil in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (6.67)	18.7374
1990's	1 (6.67)	18.2507
2000's	7 (46.67)	29.6817
2010's	6 (40.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Gozalbes, R; Pineda-Lucena, A	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Casado, A; Diaz-Rubio, E; Dominguez, S; Martin, M; Sastre, J	1
Diaz-Rubio, E; Martin-Jimenez, M; Sangro, B	1
Maggioni, F; Palmieri, A; Tropea, M; Zanchin, G	1
Clark, DS; Dordick, JS; Jordan, ET; Linhardt, RJ; Meli, L	1

Reviews

1 review(s) available for amitriptyline and fluorouracil

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Trials

1 trial(s) available for amitriptyline and fluorouracil

Article	Year
Results of two controlled studies on antiemetic combination against vomiting induced by 5-fluorouracil. Tumori, 1987, Oct-31, Volume: 73, Issue:5 Topics: Adult; Aged; Amitriptyline; Antiemetics; Clinical Trials as Topic; Diphenhydramine; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Thiethylperazine; Vomiting	1987

Other Studies

13 other study(ies) available for amitriptyline and fluorouracil

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
QSAR-based solubility model for drug-like compounds. Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19 Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Progressive loss of antiemetic efficacy during subsequent courses of chemotherapy. European journal of cancer (Oxford, England : 1990), 1992, Volume: 28, Issue:2-3 Topics: Adult; Aged; Amitriptyline; Antiemetics; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Methylprednisolone; Middle Aged; Nausea; Thiethylperazine; Vomiting	1992
Influence of physiologic hormonal modification and of hormonal treatment in a patient with a history of migraine with aura. The journal of headache and pain, 2008, Volume: 9, Issue:2 Topics: Amitriptyline; Analgesics; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Contraceptives, Oral, Hormonal; Cyclophosphamide; Endometriosis; Female; Flunarizine; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Methotrexate; Middle Aged; Migraine with Aura; Pregnancy; Selective Estrogen Receptor Modulators; Tamoxifen; Triptorelin Pamoate	2008
Influence of a three-dimensional, microarray environment on human cell culture in drug screening systems. Biomaterials, 2012, Volume: 33, Issue:35 Topics: Alginates; Amitriptyline; Antineoplastic Agents; Cell Proliferation; Cell Survival; Cells, Cultured; Culture Techniques; Cytochrome P-450 Enzyme System; Doxorubicin; Drug Screening Assays, Antitumor; Fluorescent Antibody Technique; Fluorouracil; Glucuronic Acid; Hep G2 Cells; Hexuronic Acids; Humans; Integrin beta1; Liver; Microarray Analysis; Microscopy, Confocal; Phenotype; Tamoxifen; Up-Regulation; Vascular Endothelial Growth Factor A	2012