amitriptyline and diphenhydramine

amitriptyline has been researched along with diphenhydramine in 66 studies

Research

Studies (66)

TimeframeStudies, this research(%)All Research%
pre-199029 (43.94)18.7374
1990's5 (7.58)18.2507
2000's15 (22.73)29.6817
2010's16 (24.24)24.3611
2020's1 (1.52)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD1
Strassburg, CP; Tukey, RH1
Topliss, JG; Yoshida, F1
Keserü, GM1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Nagashima, R; Nishikawa, T; Tobita, M1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Jia, L; Sun, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Antonsson, M; Bengtsson, O; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Jerndal, G; Wan, H; Winiwarter, S1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Gozalbes, R; Pineda-Lucena, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Sen, S; Sinha, N1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A1
Fijorek, K; Glinka, A; Mendyk, A; Polak, S; Wiśniowska, B1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Chai, CY; Cheng, JT; Chung, PM; Lee, HK; Wayner, MJ1
Gol'dovskaia, IL1
Diaz-Rubio, E; Martin-Jimenez, M; Sangro, B1
Kameyama, T; Nagasaka, M; Yamada, K1
Clark, TJ; Collins, JV; Goulding, R; Harris, PW; Townsend, J1
Hartmann, E1
Gyermek, L; Hill, RT; Sigg, EB1
Lish, PM; Peters, EL; Robbins, SI1
Colson, SH; Tolson, WW; Umberger, EJ1
Schrold, J1
Hartvig, P; Vessman, J1
Bhatnagar, SP1
Nymark, M1
Sargant, W1
Ray, I1
Connor, JD; Crawford, IL; Pardridge, WM1
Gordon, JL1
Brody, TM; Commarato, MA; McNeill, JH1
Mason, RG; Read, MS; Saba, SR; Shermer, RW1
Florio, V; Longo, VG1
Gross, R; Linker, H; Reuter, H1
Coyle, JT; Horn, AS; Snyder, SH1
Brody, TM; McNeill, JH1
Vaillant, GE1
Tompsett, SL1
Brightman, VJ; Christensen, CM; Navazesh, M1
McKearney, JW1
Bernstein, JE; Soltani, K; Whitney, DH1
Breyer-Pfaff, U; Fischer, D1
Jenkins, AJ; Jufer, R; Levine, B; Queen, M; Smialek, JE1
Breyer-Pfaff, U; Fischer, D; Winne, D1
Lines, C; Mant, T; Raskin, S; Reines, S; Traub, M1
Bramer, T; Edsman, K; Edwards, K; Paulsson, M1
Allen, KR; Fosnight, SM; Hazelett, S; Holder, CM1
Davies, NH; Euerby, MR; McCalley, DV1
Courtade, D; Fiess, RN; Holmes, SA; Loubser, PG; Rintala, DH; Tastard, LV1
Baran, E; Enginar, N; Karamürsel, Y; Nurten, A; Zengin, A1
Finel, M; Fukami, T; Izukawa, T; Kato, Y; Nakajima, M; Oda, S; Yokoi, T1
Neill, SG; Punja, M; Wong, S1
Kintz, P1
Blum, LM; Scanlon, KA; Starkey, SJ; Stoppacher, R1
Haefeli, WE; Kopitz, J; Mayer, T; Plaschke, K; Seidling, HM; Weiss, J1
Benz, P; Farkas, A; Ryan, K; Theobald, J; Zosel, A1

Reviews

4 review(s) available for amitriptyline and diphenhydramine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
[Psychotropic therapy and intraocular pressure].
    Oftalmologicheskii zhurnal, 1975, Volume: 30, Issue:1

    Topics: Amitriptyline; Analgesics; Antidepressive Agents; Chlorpromazine; Diazepam; Diphenhydramine; Eye Diseases; Glaucoma; Histamine H1 Antagonists; Humans; Imipramine; Intraocular Pressure; Lithium; Mental Disorders; Mephenesin; Meprobamate; Piperidines; Psychotropic Drugs; Secologanin Tryptamine Alkaloids; Tranquilizing Agents; Trihexyphenidyl

1975
Pharmacological studies of sleep and dreaming: chemical and clinical relationships.
    Biological psychiatry, 1969, Volume: 1, Issue:3

    Topics: Amitriptyline; Amphetamine; Antidepressive Agents; Atropine; Chloralose; Chlordiazepoxide; Chlorpromazine; Desipramine; Dextroamphetamine; Diazepam; Diphenhydramine; Dreams; Glutethimide; Humans; Hypnotics and Sedatives; Imipramine; Lysergic Acid Diethylamide; Meprobamate; Methaqualone; Morphine; Nialamide; Pentobarbital; Reserpine; Sleep; Sleep, REM; Tranquilizing Agents; Tranylcypromine; Triiodothyronine; Tryptophan

1969

Trials

5 trial(s) available for amitriptyline and diphenhydramine

ArticleYear
Results of two controlled studies on antiemetic combination against vomiting induced by 5-fluorouracil.
    Tumori, 1987, Oct-31, Volume: 73, Issue:5

    Topics: Adult; Aged; Amitriptyline; Antiemetics; Clinical Trials as Topic; Diphenhydramine; Drug Therapy, Combination; Female; Fluorouracil; Humans; Male; Middle Aged; Thiethylperazine; Vomiting

1987
Inhibition of histamine-induced pruritus by topical tricyclic antidepressants.
    Journal of the American Academy of Dermatology, 1981, Volume: 5, Issue:5

    Topics: Administration, Topical; Amitriptyline; Antidepressive Agents, Tricyclic; Diphenhydramine; Double-Blind Method; Doxepin; Humans; Pruritus

1981
Comparison of procedures for measuring the quaternary N-glucuronides of amitriptyline and diphenhydramine in human urine with and without hydrolysis.
    The Journal of pharmacy and pharmacology, 1995, Volume: 47, Issue:6

    Topics: Amitriptyline; Animals; Chromatography, High Pressure Liquid; Diphenhydramine; Escherichia coli; Glucuronates; Glucuronidase; Helix, Snails; Humans; Hydrolysis; Rats

1995
Lack of sedative and cognitive effects of diphenhydramine and cyclobenzaprine in elderly volunteers.
    Journal of psychopharmacology (Oxford, England), 1997, Volume: 11, Issue:4

    Topics: Aged; Aged, 80 and over; Amitriptyline; Arousal; Cognition; Diphenhydramine; Double-Blind Method; Female; Humans; Hypnotics and Sedatives; Male; Middle Aged; Tranquilizing Agents

1997
Comparison of the effectiveness of amitriptyline and gabapentin on chronic neuropathic pain in persons with spinal cord injury.
    Archives of physical medicine and rehabilitation, 2007, Volume: 88, Issue:12

    Topics: Adult; Aged; Amines; Amitriptyline; Analgesics; Analysis of Variance; Antidepressive Agents, Tricyclic; Cross-Over Studies; Cyclohexanecarboxylic Acids; Diphenhydramine; Double-Blind Method; Female; Gabapentin; gamma-Aminobutyric Acid; Histamine H1 Antagonists; Humans; Male; Middle Aged; Mononeuropathies; Pain; Pain Measurement; Spinal Cord Injuries

2007

Other Studies

57 other study(ies) available for amitriptyline and diphenhydramine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes

1999
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.
    Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16

    Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship

2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Support vector machines classification of hERG liabilities based on atom types.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Structure-brain exposure relationships in rat and human using a novel data set of unbound drug concentrations in brain interstitial and cerebrospinal fluids.
    Journal of medicinal chemistry, 2009, Oct-22, Volume: 52, Issue:20

    Topics: Animals; Blood-Brain Barrier; Brain; Extracellular Fluid; Humans; Linear Models; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
QSAR-based solubility model for drug-like compounds.
    Bioorganic & medicinal chemistry, 2010, Oct-01, Volume: 18, Issue:19

    Topics: Databases, Factual; Models, Molecular; Pharmaceutical Preparations; Quantitative Structure-Activity Relationship; Solubility; Water

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
    Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1

    Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection

2011
Predictive model for L-type channel inhibition: multichannel block in QT prolongation risk assessment.
    Journal of applied toxicology : JAT, 2012, Volume: 32, Issue:10

    Topics: Artificial Intelligence; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Computational Biology; Computer Simulation; Drugs, Investigational; Ether-A-Go-Go Potassium Channels; Expert Systems; Heart Rate; Humans; Models, Biological; Myocytes, Cardiac; NAV1.5 Voltage-Gated Sodium Channel; Potassium Channel Blockers; Quantitative Structure-Activity Relationship; Risk Assessment; Shaker Superfamily of Potassium Channels; Torsades de Pointes; Voltage-Gated Sodium Channel Blockers

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Mechanisms of amitriptyline induced hypothermia in the rat.
    Pharmacology, biochemistry, and behavior, 1977, Volume: 7, Issue:2

    Topics: Amitriptyline; Animals; Atropine; Body Temperature; Brain Chemistry; Bucladesine; Cyproheptadine; Depression, Chemical; Diphenhydramine; Fenclonine; Haloperidol; Male; Rats; Serotonin; Sympatholytics; Theophylline

1977
Effects of antidepressant drugs on a quickly-learned conditioned-suppression response in mice.
    Neuropharmacology, 1985, Volume: 24, Issue:4

    Topics: Acridines; Amitriptyline; Animals; Antidepressive Agents; Depressive Disorder; Desipramine; Diphenhydramine; Disease Models, Animal; Electroshock; Ethanol; Humans; Imipramine; Male; Maprotiline; Mianserin; Mice; Motor Activity; Nialamide; Pargyline; Tranylcypromine

1985
Plasma-11-hydroxycorticosteroid levels in drug-induced coma.
    Lancet (London, England), 1971, Jul-24, Volume: 2, Issue:7717

    Topics: Adrenal Cortex Hormones; Adrenal Glands; Amitriptyline; Barbiturates; Blood Pressure; Body Temperature; Central Nervous System; Coma; Diphenhydramine; Glucocorticoids; Glutethimide; Humans; Hypotension; Hypothalamus; Hypothermia; Methaqualone; Pituitary Gland; Rectum; Self Medication

1971
Antagonism to reserpine induced depression by imipramine, related psychoactive drugs, and some autonomic agents.
    Psychopharmacologia, 1965, Feb-15, Volume: 7, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Atropine; Behavior, Animal; Cyproheptadine; Desipramine; Diphenhydramine; Hallucinogens; Histamine H1 Antagonists; Imipramine; Lysergic Acid Diethylamide; Mice; Promazine; Psychopharmacology; Reserpine; Serotonin

1965
Specificity of antihistamine drugs and involvement of the adrenergic system in histamine deaths in the guinea pig.
    The Journal of pharmacology and experimental therapeutics, 1966, Volume: 153, Issue:3

    Topics: Adrenal Medulla; Aerosols; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Diphenhydramine; Drug Antagonism; Guinea Pigs; Histamine; Histamine H1 Antagonists; Imipramine; Phenothiazines; Shock, Septic; Sympatholytics; Tripelennamine

1966
The effects of some centrally acting drugs on the glucocorticoid induction of hepatic tyrosine transaminase.
    Life sciences, 1969, Nov-15, Volume: 8, Issue:22

    Topics: Adrenalectomy; Amitriptyline; Animals; Chlorpheniramine; Chlorpromazine; Desipramine; Diphenhydramine; Enzyme Induction; Female; Fluocinolone Acetonide; Fluorometholone; Glucocorticoids; Hydrocortisone; Imipramine; Liver; Male; Prednisone; Proadifen; Promazine; Promethazine; Rats; Reserpine; Sex Factors; Triflupromazine; Tyrosine Transaminase

1969
Behavioural effects od d-amphetamine alone and in combination with antidepressants, antihistamines or other psychotropic drugs in young chicks.
    Psychopharmacologia, 1972, Volume: 23, Issue:2

    Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Chickens; Chlorpheniramine; Cocaine; Desipramine; Dextroamphetamine; Diphenhydramine; Drug Antagonism; Drug Interactions; Histamine H1 Antagonists; Imipramine; Male; Nortriptyline; Promethazine

1972
Electron capture gas chromatography of tertiary amines after a demethylation reaction to secondary amines. II. Studies of different chloroformates and alternative hydrolysis procedures.
    Acta pharmaceutica Suecica, 1974, Volume: 11, Issue:2

    Topics: Acylation; Amitriptyline; Chromatography, Gas; Diphenhydramine; Formates; Hydrocarbons, Brominated; Hydrocarbons, Chlorinated; Hydrolysis; Imipramine; Mass Spectrometry; Methadone; Methods; Methylamines; Propylamines; Time Factors

1974
Action of some centrally active drugs and heavy metals on in vitro oxidation of dopamine by rat brain tissue.
    Canadian journal of physiology and pharmacology, 1972, Volume: 50, Issue:11

    Topics: Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Brain; Cadmium; Central Nervous System; Chlorpromazine; Choline; Diphenhydramine; Dopamine; Female; In Vitro Techniques; Iproniazid; Lead; Melanins; Metals; Methylmercury Compounds; Mitochondria; Oxidation-Reduction; Physostigmine; Rats; Serotonin; Sucrose; Time Factors; Tranquilizing Agents

1972
Apomorphine provoked stereotype in the dog.
    Psychopharmacologia, 1972, Volume: 26, Issue:4

    Topics: Amitriptyline; Animals; Anisoles; Apomorphine; Atropine; Behavior, Animal; Benzamides; Benztropine; Diazepam; Diphenhydramine; Dogs; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Ethylamines; Female; Fluphenazine; Haloperidol; Humans; Male; Methyltyrosines; Motor Activity; Phenoxybenzamine; Piperazines; Receptors, Drug; Scopolamine; Stereotyped Behavior; Xanthenes

1972
Prescribing Mandrax.
    British medical journal, 1973, Jun-23, Volume: 2, Issue:5868

    Topics: Amitriptyline; Dibenzazepines; Diphenhydramine; Electroconvulsive Therapy; Humans; Methaqualone; Sleep; Substance Withdrawal Syndrome; Substance-Related Disorders

1973
Combinations of antidepressant drugs in the treatment of depressive illness.
    Canadian Psychiatric Association journal, 1973, Volume: 18, Issue:5

    Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Benztropine; Canada; Chlorpromazine; Depression; Dibenzazepines; Diphenhydramine; Drug Synergism; Drug Therapy, Combination; Electroconvulsive Therapy; Evaluation Studies as Topic; Female; Humans; Male; Methaqualone; Middle Aged; Phenelzine; Retrospective Studies; Sleep; Tranylcypromine

1973
Permeability changes in the blood-brain barrier induced by nortriptyline and chlorpromazine.
    Toxicology and applied pharmacology, 1973, Volume: 26, Issue:1

    Topics: Amitriptyline; Animals; Autoradiography; Blood-Brain Barrier; Brain; Capillaries; Carbon Radioisotopes; Cell Membrane Permeability; Cerebral Cortex; Chlorpromazine; Desipramine; Diphenhydramine; Dopamine; Imipramine; In Vitro Techniques; Inulin; Male; Mannitol; Molecular Weight; Nortriptyline; Rats; Tritium

1973
Differential changes in potency of platelet-aggregation inhibitors after preincubation in platelet-rich plasma.
    Research communications in chemical pathology and pharmacology, 1974, Volume: 7, Issue:1

    Topics: Adenosine Diphosphate; Amitriptyline; Animals; Caffeine; Chlorpromazine; Diphenhydramine; Dipyridamole; Imipramine; Papaverine; Plasma; Platelet Adhesiveness; Swine; Time Factors; Trifluoperazine

1974
Further studies on the effect of various drugs on the uptake of tyramine-3H and formation of octopamine-3H in the rat heart.
    Canadian journal of physiology and pharmacology, 1969, Volume: 47, Issue:6

    Topics: Amitriptyline; Animals; Cocaine; Desipramine; Diphenhydramine; Female; Glucosyltransferases; Methylphenidate; Myocardium; Neurons; Norepinephrine; Octopamine; Pyridines; Rats; Sympathetic Nervous System; Triprolidine; Tritium; Tyramine

1969
Apparent similarity of mechanisms of platelet adhesion and aggregation. Differentiation of these functions from clot retraction.
    Thrombosis et diathesis haemorrhagica, 1972, Feb-29, Volume: 27, Issue:1

    Topics: Amitriptyline; Aspirin; Blood Coagulation Tests; Caffeine; Chloromercuribenzoates; Chlorpromazine; Clot Retraction; Cocaine; Diphenhydramine; Ethacrynic Acid; Guanidines; Humans; Phenothiazines; Phentolamine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Quinacrine; Quinidine; Reserpine; Sulfinpyrazone; Sulfones; Tosyl Compounds

1972
Effects of amantadine and of some synthetic antiparkinsonian drugs on the behavioral response to L-DOPA in mice.
    Physiology & behavior, 1971, Volume: 6, Issue:4

    Topics: Amantadine; Amitriptyline; Animals; Antiparkinson Agents; Atropine; Behavior, Animal; Dihydroxyphenylalanine; Diphenhydramine; Drug Synergism; Imipramine; Mice; Orphenadrine; Parasympatholytics; Pargyline; Trihexyphenidyl

1971
[A possible mechanism of disaggregation of ADP-induced aggregates by imipramin and structurally related compouds].
    Thrombosis et diathesis haemorrhagica, 1969, Nov-15, Volume: 22, Issue:2

    Topics: Adenine Nucleotides; Amitriptyline; Blood Platelets; Chlorpromazine; Desipramine; Diphenhydramine; Humans; Imipramine; Nortriptyline; Optical Rotatory Dispersion; Platelet Adhesiveness; Promazine; Promethazine

1969
Catecholamine uptake by synaptosomes from rat brain. Structure-activity relationships of drugs with differential effects on dopamine and norepinephrine neurons.
    Molecular pharmacology, 1971, Volume: 7, Issue:1

    Topics: Amitriptyline; Amphetamine; Animals; Brain; Catecholamines; Chlorpromazine; Dextroamphetamine; Diphenhydramine; Dopamine; Female; Kinetics; Nerve Endings; Norepinephrine; Ouabain; Parasympatholytics; Rats; Receptors, Drug; Tritium

1971
The effect of various drug pretreatments on amine-induced phosphorylase activation and amine uptake.
    The Journal of pharmacology and experimental therapeutics, 1968, Volume: 162, Issue:1

    Topics: Amitriptyline; Animals; Carbon Isotopes; Depression, Chemical; Desipramine; Diphenhydramine; Drug Synergism; Female; Glucosyltransferases; Heart; Imipramine; Isoproterenol; Methylphenidate; Myocardium; Norepinephrine; Promethazine; Propranolol; Rats; Stimulation, Chemical; Tranylcypromine; Triprolidine; Tritium; Tyramine

1968
Clinical significance of anticholinergic effects of imipramine-like drugs.
    The American journal of psychiatry, 1969, Volume: 125, Issue:11

    Topics: Amitriptyline; Animals; Atropine; Columbidae; Depression; Desipramine; Diphenhydramine; Humans; Imipramine; Parasympatholytics; Scopolamine

1969
The detection of basic and other drugs in urine bdistillation and UV spectrophotometry.
    Clinical chemistry, 1969, Volume: 15, Issue:7

    Topics: Amitriptyline; Amphetamine; Chemistry Techniques, Analytical; Chlorprothixene; Chromatography, Gas; Dextropropoxyphene; Diethylpropion; Diphenhydramine; Ephedrine; Ethchlorvynol; Humans; Methods; Oxyphenbutazone; Spectrophotometry; Ultraviolet Rays

1969
Effects of pharmacologic reductions in salivary flow on taste thresholds in man.
    Archives of oral biology, 1984, Volume: 29, Issue:1

    Topics: Adolescent; Adult; Amitriptyline; Atropine; Diphenhydramine; Female; Humans; Male; Saliva; Secretory Rate; Taste; Taste Threshold; Xerostomia

1984
Individual differences in effects of tricyclic antidepressants and anticholinergic drugs on operant behavior in the squirrel monkey.
    Life sciences, 1981, May-04, Volume: 28, Issue:18

    Topics: Amines; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Atropine; Behavior, Animal; Benztropine; Brain; Cebidae; Diphenhydramine; Male; Parasympatholytics; Saimiri

1981
Distribution of venlafaxine in three postmortem cases.
    Journal of analytical toxicology, 1996, Volume: 20, Issue:6

    Topics: Acetaminophen; Adult; Amitriptyline; Antidepressive Agents, Second-Generation; Bile; Chlordiazepoxide; Chromatography, Gas; Cyclohexanols; Diphenhydramine; Humans; Kidney; Liver; Male; Methylation; Middle Aged; Nortriptyline; Reference Standards; Selective Serotonin Reuptake Inhibitors; Suicide; Venlafaxine Hydrochloride

1996
Biphasic kinetics of quaternary ammonium glucuronide formation from amitriptyline and diphenhydramine in human liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 1997, Volume: 25, Issue:3

    Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Diphenhydramine; Enzyme Activation; Glucuronates; Histamine H1 Antagonists; Humans; Hydrogen-Ion Concentration; Kinetics; Microsomes, Liver; Octoxynol; Quaternary Ammonium Compounds

1997
Catanionic drug-surfactant mixtures: phase behavior and sustained release from gels.
    Pharmaceutical research, 2003, Volume: 20, Issue:10

    Topics: Amitriptyline; Anions; Cations; Delayed-Action Preparations; Diphenhydramine; Drug Carriers; Drug Compounding; Gels; Hydrogen-Ion Concentration; Micelles; Pharmaceutical Preparations; Phase Transition; Rheology; Sodium Chloride; Sodium Dodecyl Sulfate; Surface-Active Agents; Temperature; Tetracaine; Time Factors

2003
A strategy to decrease the use of risky drugs in the elderly.
    Cleveland Clinic journal of medicine, 2004, Volume: 71, Issue:7

    Topics: Aged; Amitriptyline; Clinical Pharmacy Information Systems; Contraindications; Diphenhydramine; Drug Interactions; Geriatrics; Hospital Units; Humans; Medication Systems, Hospital; Meperidine; Ohio; Risk Management; Total Quality Management

2004
Study of overload for basic compounds in reversed-phase high performance liquid chromatography as a function of mobile phase pH.
    Journal of chromatography. A, 2006, Jun-30, Volume: 1119, Issue:1-2

    Topics: Amitriptyline; Amphetamine; Chromatography, High Pressure Liquid; Diphenhydramine; Hydrogen-Ion Concentration; Nortriptyline; Quaternary Ammonium Compounds; Silanes

2006
Scopolamine-induced convulsions in fasted mice after food intake: evaluation of the sedative effect in the suppression of convulsions.
    Epilepsy research, 2010, Volume: 89, Issue:1

    Topics: Amitriptyline; Animals; Body Weight; Chlorpromazine; Diphenhydramine; Eating; Food Deprivation; Hypnotics and Sedatives; Mice; Morphine; Scopolamine; Seizures

2010
Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.
    Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:7

    Topics: Amitriptyline; Animals; Diphenhydramine; Glucuronides; Glucuronosyltransferase; Humans; Imipramine; Kinetics; Spodoptera; Substrate Specificity

2013
Caution with interpreting laboratory results after lipid rescue therapy.
    The American journal of emergency medicine, 2013, Volume: 31, Issue:10

    Topics: Acetaminophen; Amitriptyline; Aspartate Aminotransferases; Diphenhydramine; Drug Overdose; False Negative Reactions; Fat Emulsions, Intravenous; Humans; Male; Middle Aged

2013
Contribution of in utero drug exposure when interpreting hair results in young children.
    Forensic science international, 2015, Volume: 249

    Topics: Amitriptyline; Bromazepam; Cannabinoids; Diazepam; Diphenhydramine; Female; Forensic Toxicology; Hair; Heroin; Humans; Hypnotics and Sedatives; Infant; Infant, Newborn; Male; Maternal-Fetal Exchange; Methadone; Narcotics; Pregnancy; Substance-Related Disorders; Tramadol

2015
Comprehensive Duloxetine Analysis in a Fatal Overdose.
    Journal of analytical toxicology, 2016, Volume: 40, Issue:2

    Topics: Aged; Alcoholism; Amitriptyline; Depression; Diphenhydramine; Drug Overdose; Duloxetine Hydrochloride; Fatal Outcome; Female; Humans; Selective Serotonin Reuptake Inhibitors

2016
Limitations of the Anticholinergic Activity Assay and Assay-Based Anticholinergic Drug Scales.
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2016, Volume: 24, Issue:12

    Topics: Amitriptyline; Cholinergic Antagonists; Cognitive Dysfunction; Diphenhydramine; Dose-Response Relationship, Drug; Drug Interactions; Furosemide; Humans; Nortriptyline; Pilocarpine; Radioligand Assay; Thioridazine

2016
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
    Cardiovascular toxicology, 2022, Volume: 22, Issue:9

    Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long QT Syndrome; Methadone; Mirtazapine; Poison Control Centers; Retrospective Studies; Risk Factors; Tachycardia, Ventricular; Torsades de Pointes; Trazodone; Ventricular Fibrillation

2022