amitriptyline and cimetidine

amitriptyline has been researched along with cimetidine in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (21.21)	18.7374
1990's	2 (6.06)	18.2507
2000's	11 (33.33)	29.6817
2010's	13 (39.39)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET	1
Blake, JF; Curatolo, WJ; Lombardo, F	1
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Chang, TK; Ensom, MH; Kiang, TK	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bandyopadhyaya, A; Rajagopalan, DR; Rajagopalan, P; Rajagopalan, R	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Casas Carnicero, J; Fernández de la Gandara, F; Velasco Martin, A	1
Curry, SH; DeVane, CL; Wolfe, MM	2
Kurowski, M; Reim, HG	1
de Levin, RW; Levin, E; Puig, OR	1
Ishiguro, I; Kobayashi, T; Ohta, Y	1
Christopoulos, TK; Diamandis, EP; Koupparis, MA; Mitsana-Papazoglou, A	1
Dieleman, JP; Jong, GW; Stricker, BH; Sturkenboom, MC; van der Cammen, TJ; van der Hooft, CS; Verhamme, KM	1
Sea, J; Teichman, JM	1
Dancel, R; Handler, L; Mounsey, A	1
Giusto, LL; Shoskes, DA; Zahner, PM	1

Reviews

4 review(s) available for amitriptyline and cimetidine

Article	Year
UDP-glucuronosyltransferases and clinical drug-drug interactions. Pharmacology & therapeutics, 2005, Volume: 106, Issue:1 Topics: Clinical Trials as Topic; Drug Interactions; Enzyme Activation; Enzyme Induction; Glucuronides; Glucuronosyltransferase; Humans; Pharmaceutical Preparations; Pharmacogenetics; Polymorphism, Genetic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Paediatric painful bladder syndrome/interstitial cystitis: diagnosis and treatment. Drugs, 2009, Volume: 69, Issue:3 Topics: Administration, Intravesical; Amitriptyline; Child; Cimetidine; Cystitis, Interstitial; Diet Therapy; Dimethyl Sulfoxide; Humans; Hydroxyzine; Life Style; Pain; Pentosan Sulfuric Polyester	2009
An evaluation of the pharmacotherapy for interstitial cystitis. Expert opinion on pharmacotherapy, 2018, Volume: 19, Issue:10 Topics: Amitriptyline; Antibodies, Monoclonal; Antidepressive Agents, Tricyclic; Cimetidine; Cystitis, Interstitial; Histamine Antagonists; Humans; Hydroxyzine; Immunosuppressive Agents; Pentosan Sulfuric Polyester	2018

Trials

2 trial(s) available for amitriptyline and cimetidine

Article	Year
[Metabolic interaction between cimetidine, ranitidine and amitriptyline/chlordiazepoxide]. Zeitschrift fur Gastroenterologie, 1986, Volume: 24, Issue:10 Topics: Adult; Amitriptyline; Biotransformation; Chlordiazepoxide; Cimetidine; Drug Combinations; Gastric Acidity Determination; Half-Life; Humans; Male; Metabolic Clearance Rate; Ranitidine	1986
Cimetidine interaction with amitriptyline. European journal of clinical pharmacology, 1985, Volume: 29, Issue:4 Topics: Adult; Amitriptyline; Blood Pressure; Cimetidine; Clinical Trials as Topic; Double-Blind Method; Drug Interactions; Humans; Male; Nortriptyline; Psychomotor Performance; Pulse; Random Allocation; Time Factors	1985

Other Studies

27 other study(ies) available for amitriptyline and cimetidine

Article	Year
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs. Journal of medicinal chemistry, 1985, Volume: 28, Issue:3 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium	1985
Computation of brain-blood partitioning of organic solutes via free energy calculations. Journal of medicinal chemistry, 1996, Nov-22, Volume: 39, Issue:24 Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics	1996
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19 Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data. European journal of medicinal chemistry, 2009, Volume: 44, Issue:11 Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3 Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
The synthesis and comparative receptor binding affinities of novel, isomeric pyridoindolobenzazepine scaffolds. Bioorganic & medicinal chemistry letters, 2014, Jan-15, Volume: 24, Issue:2 Topics: Benzodiazepinones; Isomerism; Protein Binding; Protein Structure, Tertiary; Receptors, Cell Surface	2014
Effects of antidepressants on alcohol-induced gastric mucosal injury in rats. Methods and findings in experimental and clinical pharmacology, 1989, Volume: 11, Issue:10 Topics: Amitriptyline; Animals; Antidepressive Agents; Chlorpheniramine; Cimetidine; Ethanol; Female; Gastric Mucosa; Maprotiline; Mianserin; Rats; Rats, Inbred Strains; Stomach Ulcer; Trimipramine	1989
Pharmacology of combined antidepressant/H2-blocking drug therapy. Psychopharmacology bulletin, 1986, Volume: 22, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Cimetidine; Drug Therapy, Combination; Histamine H2 Antagonists; Humans	1986
Increased risk for cancer of the breast due to previous medication. Archiv fur Geschwulstforschung, 1984, Volume: 54, Issue:2 Topics: 20-alpha-Dihydroprogesterone; Adult; Aged; Amitriptyline; Amphetamines; Breast Neoplasms; Cimetidine; Contraceptive Agents; Estradiol; Female; Humans; Methyldopa; Middle Aged; Phenothiazines; Prolactin; Psychotropic Drugs; Quinestrol; Risk; Time Factors	1984
Role of endogenous serotonin and histamine in the pathogenesis of gastric mucosal lesions in unanaesthetised rats with a single treatment of compound 48/80, a mast cell degranulator. Pharmacological research, 1999, Volume: 39, Issue:4 Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Cell Degranulation; Cimetidine; Cyproheptadine; Famotidine; Gastric Mucosa; Histamine; Histamine H1 Antagonists; Histamine H2 Antagonists; Male; Mast Cells; Methysergide; p-Methoxy-N-methylphenethylamine; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Stomach Ulcer; Tripelennamine	1999
Dissolution studies of drug formulations using ion-selective electrodes as sensors in an air-segmented continuous flow analyzer. Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:9 Topics: Amitriptyline; Chemistry, Pharmaceutical; Chlorpromazine; Cimetidine; Electrochemistry; Electrodes; Hydrogen-Ion Concentration; Propantheline; Ranitidine; Solubility	1987
Inappropriate drug prescribing in older adults: the updated 2002 Beers criteria--a population-based cohort study. British journal of clinical pharmacology, 2005, Volume: 60, Issue:2 Topics: Aged; Amitriptyline; Anti-Infective Agents, Urinary; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Antipruritics; Benzodiazepines; Cimetidine; Cohort Studies; Comorbidity; Drug Prescriptions; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Hypnotics and Sedatives; Male; Medication Errors; Netherlands; Nitrofurantoin; Promethazine; Pyridines; Risk Assessment; Zolpidem	2005
Medications for treatment of interstitial cystitis. American family physician, 2015, Jan-15, Volume: 91, Issue:2 Topics: Adult; Amitriptyline; Cimetidine; Cystitis, Interstitial; Evidence-Based Medicine; Female; Humans; Hydroxyzine; Male; Middle Aged	2015