amitriptyline and caffeine

amitriptyline has been researched along with caffeine in 53 studies

Research

Studies (53)

TimeframeStudies, this research(%)All Research%
pre-199020 (37.74)18.7374
1990's5 (9.43)18.2507
2000's16 (30.19)29.6817
2010's12 (22.64)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Blake, JF; Curatolo, WJ; Lombardo, F1
Topliss, JG; Yoshida, F1
Faassen, F; Spanings, H; Vogel, G; Vromans, H1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY1
Lombardo, F; Obach, RS; Waters, NJ1
Ahlin, G; Artursson, P; Bergström, CA; Gustavsson, L; Karlsson, J; Larsson, R; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Boriss, H; Braggio, S; Corbioli, S; Fontana, S; Helmdach, L; Longhi, R; Schiller, J; Vinco, F1
Sen, S; Sinha, N1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, DJ; Medina, MA; Palmer, GC; Stavinoha, WB1
Coret, IA; Hughes, MJ1
Moffat, AC1
Heinze, HJ; Künkel, H1
Kalachev, BP1
Hering, R; Steiner, TJ1
Bousser, MG; Massiou, H1
Ferrini, R; Miragoli, G2
Greengard, P; Quinn, GP; Reid, MB1
Oliverio, A1
Gordon, JL1
Greenwood, DT; Sommerville, AR1
Mason, RG; Read, MS; Saba, SR; Shermer, RW1
Eich, E; Geissler, H; Mutschler, E; Schunack, W1
Senault, B1
Case, G; Hucker, H; Rickels, K; Weise, C1
Cassone, MC; Fundarò, A; Molinengo, L1
Cassone, MC; Molinengo, L1
Campos, E; Chayet, L; Collados, L; García, L; Kettlun, AM; Traverso-Cori, A; Valenzuela, MA1
Esser, MJ; Reid, AR; Sawynok, J2
Esser, MJ; Sawynok, J1
Allen, GV; Chase, T; Esser, MJ; Sawynok, J1
Aslantas, A; Dokmeci, I; Firat, Z; Karadag, HC; Tamer, M; Ulugol, A1
METYS, J; METYSOVA, J1
Mueller, LL1
Alamilla, J; Barral, J; Enríquez-Castillo, A; Flores-Serrano, AG; Góngora-Alfaro, JL; Gourbière, S; Pineda, JC1
Fredholm, BB; Reid, AR; Sawynok, J1
Akgun, A; Gidener, S; Hocaoglu, N; Kalkan, S; Tuncok, Y1
Blatter, LA; Fill, M; Qin, J; Zima, AV1
Liu, J; Reid, AR; Sawynok, J1
Duborija-Kovacevic, N; Radnic, B; Radojevic, N; Vucinic, J1

Reviews

2 review(s) available for amitriptyline and caffeine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Diagnosing and managing migraine headache.
    The Journal of the American Osteopathic Association, 2007, Volume: 107, Issue:10 Suppl 6

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Caffeine; Food; Humans; Migraine Disorders; Migraine without Aura; Treatment Outcome; Tryptamines

2007

Trials

2 trial(s) available for amitriptyline and caffeine

ArticleYear
Abrupt outpatient withdrawal of medication in analgesic-abusing migraineurs.
    Lancet (London, England), 1991, Jun-15, Volume: 337, Issue:8755

    Topics: Adult; Amitriptyline; Analgesics; Caffeine; Ergotamine; Evaluation Studies as Topic; Female; Follow-Up Studies; Headache; Humans; Male; Middle Aged; Migraine Disorders; Naproxen; Outpatients; Substance Withdrawal Syndrome; Substance-Related Disorders

1991
Tricyclic plasma levels in depressed outpatients treated with amitriptyline.
    Psychopharmacology, 1983, Volume: 80, Issue:1

    Topics: Amitriptyline; Caffeine; Depression; Female; Humans; Male; Nortriptyline; Smoking

1983

Other Studies

49 other study(ies) available for amitriptyline and caffeine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Computation of brain-blood partitioning of organic solutes via free energy calculations.
    Journal of medicinal chemistry, 1996, Nov-22, Volume: 39, Issue:24

    Topics: Animals; Blood-Brain Barrier; Brain; Cattle; Cells, Cultured; Endothelium, Vascular; Membrane Lipids; Microcirculation; Molecular Conformation; Molecular Structure; Monte Carlo Method; Permeability; Pharmaceutical Preparations; Software; Solubility; Thermodynamics

1996
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs.
    International journal of pharmaceutics, 2003, Sep-16, Volume: 263, Issue:1-2

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Caco-2 Cells; Cell Membrane Permeability; Heterocyclic Compounds; Humans; Protein Transport

2003
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
    Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5

    Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1.
    Journal of medicinal chemistry, 2008, Oct-09, Volume: 51, Issue:19

    Topics: Cell Line; Computer Simulation; Drug Design; Gene Expression Profiling; Humans; Hydrogen Bonding; Liver; Molecular Weight; Organic Cation Transporter 1; Pharmaceutical Preparations; Predictive Value of Tests; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:2

    Topics: Absorption; Albumins; Animals; Brain; Brain Chemistry; Cell Membrane; Chromatography, High Pressure Liquid; Drug Evaluation, Preclinical; In Vitro Techniques; Lipids; Male; Microdialysis; Pharmaceutical Preparations; Protein Binding; Rats; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Swine; Tissue Distribution

2011
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Influence of injected psychoactive drugs on cyclic AMP levels in mouse brain and lung following microwave irradiation.
    Neuropharmacology, 1977, Volume: 16, Issue:6

    Topics: Adenylyl Cyclases; Amitriptyline; Animals; Brain Chemistry; Caffeine; Chlorpromazine; Cyclic AMP; Dextroamphetamine; Lung; Lysergic Acid Diethylamide; Male; Methyltyrosines; Mice; Microwaves; p-Hydroxyamphetamine; Papaverine; Pargyline; Phosphoric Diester Hydrolases; Psychotropic Drugs; Reserpine

1977
A characteristic of the rate response which is common to several compounds that stimulate the heart.
    Journal of molecular and cellular cardiology, 1975, Volume: 7, Issue:8

    Topics: Amitriptyline; Animals; Caffeine; Cyclic AMP; Dose-Response Relationship, Drug; Epinephrine; Female; Guinea Pigs; Heart Atria; Heart Rate; Heterocyclic Compounds; Histamine; Male; Neurotransmitter Agents; Norepinephrine; Rabbits; Stimulation, Chemical; Theophylline

1975
The standardisation of thin-layer chromatographic systems for the identification of basic drugs.
    Journal of chromatography, 1975, Jul-16, Volume: 110, Issue:2

    Topics: Amitriptyline; Amphetamine; Caffeine; Chromatography, Thin Layer; Codeine; Hydrogen-Ion Concentration; Lidocaine; Meperidine; Pharmaceutical Preparations; Quinine; Silicon Dioxide; Solvents; Strychnine

1975
The significance of personality traits in EEG evaluation of drug effects.
    Pharmakopsychiatrie, Neuro-Psychopharmakologie, 1979, Volume: 12, Issue:2

    Topics: Amitriptyline; Caffeine; Diazepam; Electroencephalography; Humans; Personality; Pyrithioxin

1979
[Assessment of the effectiveness of autogenic training in the complex treatment of neurotic and psychopathic states].
    Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1976, Volume: 76, Issue:11

    Topics: Adolescent; Adult; Amitriptyline; Amobarbital; Antisocial Personality Disorder; Autogenic Training; Caffeine; Chlorpromazine; Drug Combinations; Female; Humans; Hysteria; Male; Middle Aged; Neurotic Disorders

1976
[Antimigrainous agents. General considerations and treatment of the crisis].
    La Revue du praticien, 1986, Jan-21, Volume: 36, Issue:5

    Topics: Acupuncture Therapy; Amitriptyline; Analgesics; Anti-Anxiety Agents; Anti-Inflammatory Agents; Antiemetics; Caffeine; Dihydroergotamine; Ergotamine; Ergotamines; Humans; Migraine Disorders

1986
[The effect of glaziovine on exploratory behavior of normal mice in the so-called "holey board" test].
    Bollettino della Societa italiana di biologia sperimentale, 1974, Oct-15, Volume: 50, Issue:19

    Topics: Amitriptyline; Animals; Anti-Anxiety Agents; Aporphines; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Exploratory Behavior; Female; Mice

1974
[Effect of glaziovine on exploratory activity of aggressive mice in the so-called "holey board" test].
    Bollettino della Societa italiana di biologia sperimentale, 1974, Oct-15, Volume: 50, Issue:19

    Topics: Aggression; Amitriptyline; Animals; Anti-Anxiety Agents; Aporphines; Ascorbic Acid; Behavior, Animal; Caffeine; Chlordiazepoxide; Exploratory Behavior; Humans; Male; Mice

1974
Prevention by antidepressant drugs of reserpine effect on pyridine nucleotide metabolism.
    Molecular pharmacology, 1966, Volume: 2, Issue:4

    Topics: Aminopyrine; Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Atropine; Benactyzine; Caffeine; Chlorpheniramine; Chlorpromazine; Female; Hexobarbital; Hydralazine; Hypothalamus; Imipramine; Iproniazid; Isoniazid; Liver; Meprobamate; Methacholine Compounds; Morphine; NAD; Niacinamide; Pargyline; Pentobarbital; Phenylbutazone; Phenytoin; Quinacrine; Rats; Reserpine; Tranylcypromine; Tripelennamine; Zoxazolamine

1966
[Anti-fatigue effect of amphetamine and central-stimulating drugs on the performance of mice during prolonged conditioning sessions].
    Il Farmaco; edizione scientifica, 1967, Volume: 22, Issue:3

    Topics: Amitriptyline; Amphetamine; Animals; Behavior, Animal; Caffeine; Catecholamines; Central Nervous System Stimulants; Conditioning, Psychological; Imipramine; Male; Mice; Nicotine; Pentylenetetrazole; Scopolamine; Strychnine; Sympathomimetics

1967
Differential changes in potency of platelet-aggregation inhibitors after preincubation in platelet-rich plasma.
    Research communications in chemical pathology and pharmacology, 1974, Volume: 7, Issue:1

    Topics: Adenosine Diphosphate; Amitriptyline; Animals; Caffeine; Chlorpromazine; Diphenhydramine; Dipyridamole; Imipramine; Papaverine; Plasma; Platelet Adhesiveness; Swine; Time Factors; Trifluoperazine

1974
The effect of immunosympathectomy on the responses of the mouse to reserpine and various antidepressant and stimulant drugs.
    Psychopharmacologia, 1972, Volume: 24, Issue:2

    Topics: Amitriptyline; Amphetamine; Animals; Antidepressive Agents; Body Temperature; Caffeine; Hydrazines; Imipramine; Immune Sera; Mice; Mice, Inbred Strains; Monoamine Oxidase Inhibitors; Reserpine; Sympathetic Nervous System

1972
Apparent similarity of mechanisms of platelet adhesion and aggregation. Differentiation of these functions from clot retraction.
    Thrombosis et diathesis haemorrhagica, 1972, Feb-29, Volume: 27, Issue:1

    Topics: Amitriptyline; Aspirin; Blood Coagulation Tests; Caffeine; Chloromercuribenzoates; Chlorpromazine; Clot Retraction; Cocaine; Diphenhydramine; Ethacrynic Acid; Guanidines; Humans; Phenothiazines; Phentolamine; Phenylbutazone; Platelet Adhesiveness; Promethazine; Quinacrine; Quinidine; Reserpine; Sulfinpyrazone; Sulfones; Tosyl Compounds

1972
[Direct quantitative evaluation of thin layer chromatogramms by remission- and fluorescence measurement. 2. Determination of drugs in 2 combination preparations by remission measurements].
    Arzneimittel-Forschung, 1969, Volume: 19, Issue:11

    Topics: Amitriptyline; Aspirin; Caffeine; Capsules; Chlordiazepoxide; Chromatography, Thin Layer; Codeine; Phenacetin; Phenobarbital; Phosphates; Spectrophotometry; Tablets

1969
[Intraspecific aggressive behavior induced by apomorphine in the rat].
    Psychopharmacologia, 1970, Volume: 18, Issue:3

    Topics: Acepromazine; Age Factors; Aggression; Amitriptyline; Animals; Apomorphine; Atropine; Behavior, Animal; Caffeine; Chlordiazepoxide; Chlorpromazine; Dextroamphetamine; Diazepam; Drug Antagonism; Electroshock; Environment; Haloperidol; Humans; Hydroxyzine; Imipramine; Male; Meprobamate; Morphine; Rats; Reserpine; Sex Factors; Sound; Species Specificity; Thiazines; Thioridazine

1970
Action of antidepressants, stimulants and depressants in the transition from a fixed ratio to a fixed interval schedule of reinforcement.
    Progress in neuro-psychopharmacology & biological psychiatry, 1983, Volume: 7, Issue:1

    Topics: Amitriptyline; Amphetamine; Animals; Caffeine; Chlorpromazine; Conditioning, Operant; Diazepam; Doxepin; Imipramine; Male; Psychotropic Drugs; Rats; Rats, Inbred Strains; Reinforcement Schedule

1983
Action of thyroid hormones, diazepam, caffeine and amitriptyline on memory decay ("forgetting").
    Life sciences, 1981, Nov-09, Volume: 29, Issue:19

    Topics: Amitriptyline; Animals; Caffeine; Diazepam; Hyperthyroidism; Hypothyroidism; Male; Memory; Methimazole; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyroxine

1981
Human placental ecto-enzymes: studies on the plasma membrane anchorage and effect of inhibitors of ATP-metabolizing enzymes.
    Research communications in molecular pathology and pharmacology, 1997, Volume: 96, Issue:1

    Topics: 5'-Nucleotidase; Alkaline Phosphatase; Amitriptyline; Apyrase; Caffeine; Cell Membrane; Endopeptidases; Enzyme Inhibitors; Female; Fluphenazine; Glycosylphosphatidylinositols; Humans; Lidocaine; Microvilli; Nucleotides; Phosphatidylinositol Diacylglycerol-Lyase; Phospholipase D; Placenta; Type C Phospholipases

1997
Peripheral antinociceptive action of amitriptyline in the rat formalin test: involvement of adenosine.
    Pain, 1999, Volume: 80, Issue:1-2

    Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Dose-Response Relationship, Drug; Male; Pain; Pain Measurement; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Glutamate; Receptors, Histamine; Receptors, Opioid

1999
Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat.
    Pain, 1999, Volume: 82, Issue:2

    Topics: Adrenergic Uptake Inhibitors; Amitriptyline; Animals; Caffeine; Desipramine; Drug Evaluation, Preclinical; Fluoxetine; Male; Neuralgia; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Spinal Nerves

1999
Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain.
    European journal of pharmacology, 2000, Jul-07, Volume: 399, Issue:2-3

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spinal; Ligation; Male; Pain; Rats; Rats, Sprague-Dawley; Spinal Nerves

2000
Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: multiple interactions.
    European journal of pharmacology, 2001, Nov-02, Volume: 430, Issue:2-3

    Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Drinking; Drug Interactions; Ligation; Male; Neuralgia; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Spinal Nerves; Time Factors; Weight Gain

2001
Involvement of adenosine in the anti-allodynic effect of amitriptyline in streptozotocin-induced diabetic rats.
    Neuroscience letters, 2002, Aug-09, Volume: 328, Issue:2

    Topics: Adenosine; Amitriptyline; Analgesics; Animals; Antidepressive Agents, Tricyclic; Caffeine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Response Relationship, Drug; Drug Interactions; Female; Hyperalgesia; Neuralgia; Nociceptors; Pain Measurement; Pain Threshold; Peripheral Nerves; Phosphodiesterase Inhibitors; Physical Stimulation; Rats; Rats, Sprague-Dawley

2002
PHARMACOLOGICAL PROPERTIES OF THE DESMETHYL DERIVATIVES OF SOME ANTIDEPRESSANTS OF IMIPRAMINE TYPE.
    International journal of neuropharmacology, 1965, Volume: 4

    Topics: Amitriptyline; Animals; Antidepressive Agents; Caffeine; Desipramine; Hypothermia; Hypothermia, Induced; Imipramine; Injections, Intraperitoneal; Mice; Nortriptyline; Pentylenetetrazole; Peptic Ulcer; Rats; Research; Reserpine; Selective Serotonin Reuptake Inhibitors; Serotonin; Strychnine; Toxicology; Tranquilizing Agents

1965
Differential effects of caffeine on the antidepressant-like effect of amitriptyline in female rat subpopulations with low and high immobility in the forced swimming test.
    Physiology & behavior, 2008, Jun-09, Volume: 94, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Drug Interactions; Female; Immobility Response, Tonic; Motor Activity; Rats; Rats, Wistar; Swimming; Time Factors

2008
Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors.
    Neuroscience letters, 2008, Aug-01, Volume: 440, Issue:2

    Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Caffeine; Central Nervous System Stimulants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Female; Genotype; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain Measurement; Pain Threshold; Receptor, Adenosine A1

2008
Effects of adenosine receptor antagonists on amitriptyline-induced QRS prolongation in isolated rat hearts.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:7

    Topics: Amitriptyline; Animals; Caffeine; Dose-Response Relationship, Drug; Heart; Heart Diseases; In Vitro Techniques; Male; Purinergic P1 Receptor Antagonists; Random Allocation; Rats; Rats, Wistar; Xanthines

2008
Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes.
    American journal of physiology. Heart and circulatory physiology, 2008, Volume: 295, Issue:5

    Topics: Adenosine Triphosphate; Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Caffeine; Calcium Signaling; Calsequestrin; Cats; Dose-Response Relationship, Drug; Heart Ventricles; Microsomes; Myocytes, Cardiac; Rabbits; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases

2008
Spinal serotonin 5-HT7 and adenosine A1 receptors, as well as peripheral adenosine A1 receptors, are involved in antinociception by systemically administered amitriptyline.
    European journal of pharmacology, 2013, Jan-05, Volume: 698, Issue:1-3

    Topics: Adenosine A1 Receptor Antagonists; Amitriptyline; Analgesics; Animals; Caffeine; Female; Gene Knockdown Techniques; Humans; Male; Mice; Mice, Inbred C57BL; Peripheral Nervous System; Phenols; Pyrazoles; Receptor, Adenosine A1; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Spinal Cord; Sulfonamides; Tetrahydronaphthalenes; Time Factors; Xanthines

2013
The association between pro-arrhythmic agents and aortic stenosis in young adults: is it sufficient to clarify the sudden unexpected deaths?
    Cardiology in the young, 2017, Volume: 27, Issue:5

    Topics: Adult; Amitriptyline; Aortic Valve Stenosis; Arrhythmias, Cardiac; Autopsy; Caffeine; Death, Sudden, Cardiac; Ethanol; Female; Heart Defects, Congenital; Humans; Incidence; Male; Montenegro; Risk Factors; Terfenadine; Young Adult

2017