amitriptyline has been researched along with 10-hydroxynortriptyline in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (50.00) | 18.7374 |
| 1990's | 9 (45.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Baettig, D; Baumann, P; Breyer-Pfaff, U; Jonzier-Perey, M; Monney, C; Nill, K; Nusser, E; Pfandl, B | 1 |
| Aberg-Wistedt, A; Bertilsson, L; Dahl, ML; Nordin, C; Otani, K | 1 |
| Breyer-Pfaff, U; Gaertner, HJ; Giedke, H; Nill, K | 1 |
| Liu, P | 1 |
| de Wolff, FA; Edelbroek, PM; Linssen, AC; Rooymans, HG; Zitman, FG | 1 |
| Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D | 1 |
| Albright, D; Cooper, TB; Corcella, J; Howard, D; Robinson, DS | 1 |
| Cohen, J; Dixon, R | 1 |
| Bertilsson, L; Ekqvist, B; Sjöqvist, F; Wägner, A | 1 |
| Hurst, HE; Jones, DR; Lukey, BJ | 1 |
| de Wolff, FA; Edelbroek, PM; Rooymans, HG; Schreuder, JN; Zitman, FG | 1 |
| Breyer-Pfaff, U; Brinkschulte, M; Gaertner, HJ; Kreuter, F; Scharek, G; Wiatr, R | 1 |
| Morita, S; Noguchi, T; Ozeki, Y; Shibasaki, M; Shimoda, K; Someya, T; Takahashi, S | 1 |
| Coudoré, F; Eschalier, A; Fialip, J; Lavarenne, J | 1 |
| Breyer-Pfaff, U; Entenmann, KN; Gaertner, HJ; Nill, K | 1 |
| Gu, NF; Jiang, WD; Yin, JL; Yu, P; Zhang, XH | 1 |
| Besson, A; Coudoré, F; Courteix, C; Eschalier, A; Fialip, J; Lavarenne, J | 1 |
| Besson, A; Coudore, F; Eschalier, A; Fialip, J; Lavarenne, J | 1 |
| Bach, MV; Baker, GB; Coutts, RT | 1 |
| Belivanis, SD; Fragoulis, M; Stiakakis, I; Tsatsakis, AM; Tzatzarakis, MN | 1 |
3 trial(s) available for amitriptyline and 10-hydroxynortriptyline
| Article | Year |
|---|---|
Validation of a therapeutic plasma level range in amitriptyline treatment of depression.
Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Psychiatric Status Rating Scales | 1989 |
Analgesic and antidepressive effects of low-dose amitriptyline in relation to its metabolism in patients with chronic pain.
Topics: Adult; Amitriptyline; Analgesics; Antidepressive Agents; Chronic Disease; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Middle Aged; Nortriptyline; Pain; Random Allocation; Sex Characteristics; Time Factors | 1986 |
Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients.
Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Humans; Kinetics; Middle Aged; Nortriptyline | 1985 |
17 other study(ies) available for amitriptyline and 10-hydroxynortriptyline
| Article | Year |
|---|---|
Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes.
Topics: Adult; Amitriptyline; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Isoenzymes; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Nortriptyline; Phenotype; Regression Analysis; Stereoisomerism | 1992 |
Stereoselective efflux of (E)-10-hydroxynortriptyline enantiomers from the cerebrospinal fluid of depressed patients.
Topics: Adult; Amitriptyline; Biological Transport, Active; Depressive Disorder; Female; Humans; Middle Aged; Nortriptyline; Protein Binding; Stereoisomerism; Ultrafiltration | 1991 |
[Relation of plasma levels and clinical response to amitriptyline in treating endogenous depression].
Topics: Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline | 1988 |
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin.
Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Kinetics; Male; Mephenytoin; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic | 1986 |
Steady state plasma concentration profiles and therapeutic response in anxious-depressed outpatients after administration of a chlordiazepoxide-amitriptyline combination.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Chlordiazepoxide; Depressive Disorder; Drug Combinations; Female; Humans; Male; Middle Aged; Nordazepam; Nortriptyline | 1983 |
Weak binding of 10-hydroxymetabolites of nortriptyline to rat brain muscarinic acetylcholine receptors.
Topics: Amitriptyline; Animals; Binding, Competitive; Brain; In Vitro Techniques; Male; Nortriptyline; Quinuclidinyl Benzilate; Rats; Rats, Inbred Strains; Receptors, Muscarinic; Stereoisomerism | 1984 |
Quantification of amitriptyline, nortriptyline, and 10-hydroxy metabolite isomers in plasma by capillary gas chromatography with nitrogen-sensitive detection.
Topics: Amitriptyline; Chemical Phenomena; Chemistry; Chromatography, Gas; Humans; Nortriptyline | 1983 |
Amitriptyline metabolism in relation to antidepressive effect.
Topics: Adult; Amitriptyline; Chromatography, High Pressure Liquid; Depressive Disorder; Female; Humans; Male; Middle Aged; Nortriptyline; Riboflavin | 1984 |
Antidepressive effect and pharmacokinetics of amitriptyline with consideration of unbound drug and 10-hydroxynortriptyline plasma levels.
Topics: Adult; Aged; Amitriptyline; Biotransformation; Blood Proteins; Depressive Disorder; Female; Humans; Kinetics; Male; Methoxyhydroxyphenylglycol; Middle Aged; Nortriptyline; Protein Binding; Psychiatric Status Rating Scales | 1982 |
Interindividual variations of desmethylation and hydroxylation of amitriptyline in a Japanese psychiatric population.
Topics: Adult; Aged; Amitriptyline; Biotransformation; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation; Japan; Male; Mental Disorders; Methylation; Middle Aged; Nortriptyline | 1995 |
Mice plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after half-life repeated administration. Comparison with acute administration.
Topics: Amitriptyline; Animals; Brain; Dealkylation; Half-Life; Male; Mice; Nortriptyline | 1994 |
Secretion of amitriptyline and metabolites into breast milk.
Topics: Adult; Amitriptyline; Bipolar Disorder; Female; Humans; Infant, Newborn; Milk, Human; Nortriptyline; Postpartum Period; Pregnancy; Pregnancy Complications | 1995 |
[Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers].
Topics: Adult; Amitriptyline; Asian People; Debrisoquin; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Nortriptyline; Phenotype; Polymorphism, Genetic; Species Specificity | 1993 |
Pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites in streptozocin-induced diabetic rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Diabetes Mellitus, Experimental; Hydroxylation; Injections, Intraperitoneal; Male; Nortriptyline; Rats; Rats, Sprague-Dawley | 1996 |
Plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after one and six half-life repeated administrations to rats.
Topics: Amitriptyline; Animals; Antidepressive Agents, Tricyclic; Brain; Half-Life; Male; Nortriptyline; Rats; Rats, Sprague-Dawley | 1996 |
Metabolism of amitriptyline with CYP2D6 expressed in a human cell line.
Topics: Acylation; Amitriptyline; Antidepressive Agents, Tricyclic; Cell Line; Chromatography, Gas; Cytochrome P-450 CYP2D6; Humans; Microsomes; Nortriptyline | 1997 |
Disputed case of homicide by smothering due to severe amitriptyline intoxication of the victim.
Topics: Adult; Alcoholism; Amitriptyline; Antidepressive Agents, Tricyclic; Asphyxia; Contusions; Facial Injuries; Female; Forensic Pathology; Forensic Toxicology; Gas Chromatography-Mass Spectrometry; Homicide; Humans; Nortriptyline; Purpura | 2009 |