Compounds > amitriptyline

amitriptyline and 10-hydroxyamitriptyline

amitriptyline has been researched along with 10-hydroxyamitriptyline in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (30.77)	18.7374
1990's	8 (61.54)	18.2507
2000's	1 (7.69)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baettig, D; Baumann, P; Breyer-Pfaff, U; Jonzier-Perey, M; Monney, C; Nill, K; Nusser, E; Pfandl, B	1
Zhang, X	1
Breyer-Pfaff, U; Nill, K; Nusser, E	1
Baumann, P; Jonzier-Perey, M; Koeb, L; Küpfer, A; Schöpf, J; Tinguely, D	1
Albright, D; Cooper, TB; Corcella, J; Howard, D; Robinson, DS	1
Hurst, HE; Jones, DR; Lukey, BJ	1
Irikura, T; Ishida, R; Ozaki, T; Uchida, H	1
Morita, S; Noguchi, T; Ozeki, Y; Shibasaki, M; Shimoda, K; Someya, T; Takahashi, S	1
Coudoré, F; Eschalier, A; Fialip, J; Lavarenne, J	1
Gu, NF; Jiang, WD; Yin, JL; Yu, P; Zhang, XH	1
Bach, MV; Baker, GB; Coutts, RT	1
Besson, A; Chevalier, A; Coudoré, F; Eschalier, A; Fialip, J; Lavarenne, J; Massingham, R; Shrivastava, R	1
Gergov, M; Koski, A; Ojanperä, I; Sajantila, A; Sistonen, J; Vuori, E	1

Trials

1 trial(s) available for amitriptyline and 10-hydroxyamitriptyline

Article	Year
Amitriptyline and hydroxylated metabolite plasma levels in depressed outpatients. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:2 Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Humans; Kinetics; Middle Aged; Nortriptyline	1985

Other Studies

12 other study(ies) available for amitriptyline and 10-hydroxyamitriptyline

Article	Year
Enantioselective amitriptyline metabolism in patients phenotyped for two cytochrome P450 isozymes. Clinical pharmacology and therapeutics, 1992, Volume: 52, Issue:4 Topics: Adult; Amitriptyline; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Isoenzymes; Male; Mephenytoin; Metabolic Clearance Rate; Middle Aged; Nortriptyline; Phenotype; Regression Analysis; Stereoisomerism	1992
[Serum concentrations of amitriptyline and its metabolites and clinical effect in depressive patients]. Zhonghua shen jing jing shen ke za zhi = Chinese journal of neurology and psychiatry, 1992, Volume: 25, Issue:4 Topics: Adult; Aged; Amitriptyline; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; Nortriptyline	1992
Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine. Journal of chromatography, 1990, Jun-08, Volume: 528, Issue:1 Topics: Amitriptyline; Chromatography, High Pressure Liquid; Female; Glucuronates; Humans; Molecular Structure; Stereoisomerism	1990
Amitriptyline pharmacokinetics and clinical response: II. Metabolic polymorphism assessed by hydroxylation of debrisoquine and mephenytoin. International clinical psychopharmacology, 1986, Volume: 1, Issue:2 Topics: Adult; Amitriptyline; Debrisoquin; Depressive Disorder; Female; Humans; Hydantoins; Hydroxylation; Isoquinolines; Kinetics; Male; Mephenytoin; Middle Aged; Nortriptyline; Phenotype; Polymorphism, Genetic	1986
Quantification of amitriptyline, nortriptyline, and 10-hydroxy metabolite isomers in plasma by capillary gas chromatography with nitrogen-sensitive detection. Journal of chromatography, 1983, Dec-09, Volume: 278, Issue:2 Topics: Amitriptyline; Chemical Phenomena; Chemistry; Chromatography, Gas; Humans; Nortriptyline	1983
Gas chromatographic--mass spectrometric determination of amitriptyline and its major metabolites in human serum. Journal of chromatography, 1984, Jan-13, Volume: 305, Issue:1 Topics: Amitriptyline; Biotransformation; Gas Chromatography-Mass Spectrometry; Humans; Male; Nortriptyline	1984
Interindividual variations of desmethylation and hydroxylation of amitriptyline in a Japanese psychiatric population. Journal of clinical psychopharmacology, 1995, Volume: 15, Issue:3 Topics: Adult; Aged; Amitriptyline; Biotransformation; Dose-Response Relationship, Drug; Female; Humans; Hydroxylation; Japan; Male; Mental Disorders; Methylation; Middle Aged; Nortriptyline	1995
Mice plasma and brain pharmacokinetics of amitriptyline and its demethylated and hydroxylated metabolites after half-life repeated administration. Comparison with acute administration. Fundamental & clinical pharmacology, 1994, Volume: 8, Issue:6 Topics: Amitriptyline; Animals; Brain; Dealkylation; Half-Life; Male; Mice; Nortriptyline	1994
[Relationship between amitriptyline metabolism and polymorphic debrisoquine hydroxylation in native Chinese volunteers]. Yao xue xue bao = Acta pharmaceutica Sinica, 1993, Volume: 28, Issue:2 Topics: Adult; Amitriptyline; Asian People; Debrisoquin; Humans; Hydroxylation; Male; Metabolic Clearance Rate; Nortriptyline; Phenotype; Polymorphism, Genetic; Species Specificity	1993
Metabolism of amitriptyline with CYP2D6 expressed in a human cell line. Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:1 Topics: Acylation; Amitriptyline; Antidepressive Agents, Tricyclic; Cell Line; Chromatography, Gas; Cytochrome P-450 CYP2D6; Humans; Microsomes; Nortriptyline	1997
Comparison of amitriptyline metabolism in hepatocytes from streptozocin-induced diabetic rats and from non-diabetic rats. Cell biology and toxicology, 1997, Volume: 13, Issue:2 Topics: Amitriptyline; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Glucuronidase; Liver; Male; Rats; Rats, Sprague-Dawley; Streptozocin; Time Factors	1997
CYP2D6 and CYP2C19 genotypes and amitriptyline metabolite ratios in a series of medicolegal autopsies. Forensic science international, 2006, May-10, Volume: 158, Issue:2-3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Aryl Hydrocarbon Hydroxylases; Chromatography, Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2D6; Forensic Medicine; Gene Frequency; Genotype; Humans; Mixed Function Oxygenases; Nortriptyline	2006