amitriptyline, perphenazine drug combination has been researched along with amitriptyline in 8 studies
*Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. [MeSH]
*Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines. [MeSH]
| Studies (amitriptyline, perphenazine drug combination) | Trials (amitriptyline, perphenazine drug combination) | Recent Studies (post-2010) (amitriptyline, perphenazine drug combination) | Studies (amitriptyline) | Trials (amitriptyline) | Recent Studies (post-2010) (amitriptyline) |
|---|---|---|---|---|---|
| 8 | 1 | 0 | 6,935 | 1,381 | 1,060 |
| Protein | Taxonomy | amitriptyline, perphenazine drug combination (IC50) | amitriptyline (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.006 | |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | 0.023 | |
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.081 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0053 | |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | 0.3 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.044 | |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M5 | Homo sapiens (human) | 0.008 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.1755 | |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | 0.3 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 0.011 | |
| D(2) dopamine receptor | Homo sapiens (human) | 1.009 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.044 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.004 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0295 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 1.02 | |
| Muscarinic acetylcholine receptor M3 | Homo sapiens (human) | 0.026 | |
| D(1A) dopamine receptor | Homo sapiens (human) | 0.355 | |
| Sodium-dependent noradrenaline transporter | Homo sapiens (human) | 1.0324 | |
| Histamine H2 receptor | Homo sapiens (human) | 0.73 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.105 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.015 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.006 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 1.02 | |
| 5-hydroxytryptamine receptor 1D | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 1F | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 2B | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 6 | Rattus norvegicus (Norway rat) | 0.044 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.2756 | |
| 5-hydroxytryptamine receptor 7 | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 5A | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 5B | Rattus norvegicus (Norway rat) | 0.044 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.0048 | |
| D(3) dopamine receptor | Homo sapiens (human) | 0.182 | |
| 5-hydroxytryptamine receptor 3A | Rattus norvegicus (Norway rat) | 0.044 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.07 | |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | 0.66 | |
| 5-hydroxytryptamine receptor 6 | Homo sapiens (human) | 0.14 | |
| Potassium voltage-gated channel subfamily H member 2 | Homo sapiens (human) | 7.2446 | |
| Sodium channel protein type 5 subunit alpha | Homo sapiens (human) | 1.6 | |
| Sodium channel protein type 9 subunit alpha | Homo sapiens (human) | 4 | |
| 5-hydroxytryptamine receptor 4 | Rattus norvegicus (Norway rat) | 0.044 | |
| Sodium channel protein type 2 subunit alpha | Homo sapiens (human) | 3.1 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 1.031 | |
| 5-hydroxytryptamine receptor 3B | Rattus norvegicus (Norway rat) | 0.044 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (87.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sachdev, P | 1 |
| Balss, G; Berzewski, H; Volsan, O | 1 |
| Shea, JJ | 1 |
| Gálvez, AM; Martínez Calatayud, J; Mateo, JV | 1 |
| KENNEDY, RE; MILLER, JJ | 1 |
| ERSEVIM, I; JONES, F; KARACAN, I | 1 |
| PENNINGTON, VM | 1 |
| GERST, D; KRIS, EB | 1 |
1 review(s) available for amitriptyline, perphenazine drug combination and amitriptyline
| Article | Year |
|---|---|
Medical treatment of tinnitus.
Topics: Amitriptyline; Anti-Arrhythmia Agents; Auditory Pathways; Drug Combinations; Humans; Lidocaine; Pain; Perphenazine; Tinnitus; Tocainide | 1984 |
1 trial(s) available for amitriptyline, perphenazine drug combination and amitriptyline
| Article | Year |
|---|---|
[Multicenter study with a combination preparation of amitriptyline and perphenazine. Study of 48 established practicing neurologists].
Topics: Adult; Aged; Amitriptyline; Anxiety Disorders; Bipolar Disorder; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Combinations; Female; Humans; Male; Middle Aged; Perphenazine | 1983 |
6 other study(ies) available for amitriptyline, perphenazine drug combination and amitriptyline
| Article | Year |
|---|---|
Combined antidepressant-antipsychotic drug preparations.
Topics: Amitriptyline; Drug Combinations; Dyskinesia, Drug-Induced; Humans; Male; Middle Aged; Perphenazine | 1988 |
Simultaneous dissolution profiles of two drugs, sulfadiazine-trimethoprim and amitriptyline-perphenazine, in solid oral dosage forms by a FIA manifold provided with a single spectrophotometric detector.
Topics: Administration, Oral; Amitriptyline; Dosage Forms; Drug Combinations; Flow Injection Analysis; Perphenazine; Solubility; Spectrophotometry; Sulfadiazine; Trimethoprim | 2002 |
Amitriptyline-perphenazine in the treatment of schizophrenia.
Topics: Amitriptyline; Antidepressive Agents; Drug Combinations; Humans; Perphenazine; Schizophrenia | 1963 |
EVALUATION OF COMBINED ANTIDEPRESSANT AND TRANQUILIZINGDRUG (AMITRIPTYLINE-PERPHENAZINE) IN THE TREATMENT OF HOSPITALIZED CHRONIC SCHIZOPHRENICPATIENTS.
Topics: Amitriptyline; Antidepressive Agents; Drug Combinations; Humans; Perphenazine; Psychological Tests; Schizophrenia | 1963 |
THE PHRENOTROPIC ACTION OF PERPHENAZINE-AMITRIPTYLINE.
Topics: Amitriptyline; Anxiety; Biomedical Research; Depression; Depressive Disorder; Drug Combinations; Humans; Mental Disorders; Perphenazine; Toxicology | 1964 |
COMBINED PERPHENAZINE-AMITRIPTYLINE AS ADJUVANT THERAPY IN PSYCHIATRIC AFTERCARE.
Topics: Aftercare; Amitriptyline; Depression; Depressive Disorder; Drug Combinations; Drug Therapy; Humans; Mental Disorders; Perphenazine; Psychotic Disorders; Toxicology | 1964 |