amiodarone and metoprolol

amiodarone has been researched along with metoprolol in 83 studies

Research

Studies (83)

Timeframe	Studies, this research(%)	All Research%
pre-1990	7 (8.43)	18.7374
1990's	11 (13.25)	18.2507
2000's	35 (42.17)	29.6817
2010's	27 (32.53)	24.3611
2020's	3 (3.61)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Pajeva, IK; Wiese, M	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Dalvie, D; Loi, CM; Smith, DA	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y	1
Bashir, Y; Camm, AJ; Farrell, TG; Griffith, MJ; Paul, VE; Sneddon, JF; Ward, DE	1
Herms, J; Kuck, KH; Schneider, M; Siebels, J	1
Camm, AJ; Griffith, M; Paul, V; Ward, DE	1
Farfel, Z; Leor, J; Levartowsky, D; Sharon, C	1
Burkart, F; Pfisterer, M	1
Hess, DS; Scheinman, MM	1
Delise, P; Di Pede, F; Piccolo, E; Raviele, A	1
Maisano, G; Molinis, G; Tuniz, D; Valente, M	1
Carlsson, B; Drvota, V; Häggblad, J; Sylvén, C	1
Bayes de Luna, A; Cosin, J; Guindo, J; Marrugat, J; Navarro-López, F	1
Cappato, R; Kuck, KH; Rüppel, R; Schneider, MA; Siebels, J	2
Kuck, KH; Siebels, J	1
Kosmala, W	1
Dorian, P; Greene, M; Nanthakumar, K; Newman, D; Paquette, M; Rakovich, G	1
Fries, R; Heisel, A; Schieffer, H	1
Aurier, E; Bartoletti, A; Caponi, D; Carboni, A; Contini, S; Favaro, L; Finardi, A; Gherli, T; Lepera, G; Maranga, SS; Naccarella, F; Rolli, A	1
Cappato, R; Kuck, KH; Rüppel, R; Siebels, J	1
Bodor, E; Gellér, L; Matkó, I; Merkely, B; Moravcsik, E; Szabó, T; Szabolcs, Z; Turbók, E; Vágó, H	1
Aizawa, Y; Taneda, K	1
Catav, Z; Gunaydin, S; Kandemir, O; Tokmakoglu, H; Yorgancioglu, C; Zorlutuna, Y	1
Alexopoulos, GP; Anastasiou-Nana, MI; Margari, ZJ; Nanas, JN; Rapti, AC; Terrovitis, JV	1
Baker, J; Chauhan, V; Damle, R; Fain, E; Mazuz, M; O'Neill, PG; Ross, T; Sharma, AD; Skadsen, A; Zhang, Z	1
Caplain, H; Damy, T; Hulot, JS; Lechat, P; Pousset, F	1
Bass, EB; Tamariz, LJ	1
Auer, J; Berent, R; Eber, B; Hartl, P; Lamm, G; Lassnig, E; Lehner, E; Ng, CK; Puschmann, R; Schwarz, C; Strasser, U; Weber, T	1
Boczor, S; Cappato, R; Kuck, KH	1
Bozhko, AA; Kanopskiĭ, SG; Staritskiĭ, AG	1
Brune, K; Daniel, WG; Eschenhagen, T; Fromm, MF; Schaefer, S; Werner, D; Werner, U; Wuttke, H	1
Basvaraj, S; Dubey, B; Kumar, M; Kumar, R; Lakhotia, R; Mohanty, S	1
Anastasiou-Nana, MI; Kanakakis, J; Rokas, S; Tsagalou, EP	1
Kowey, PR	1
Glass, L; Mangin, L; Pagé, P; Vinet, A	1
Champagne, J; Connolly, SJ; Dorian, P; Fain, E; Gent, M; Hohnloser, SH; Israel, CW; Roberts, R	1
Cai, Y; Jia, J; Li, S; Liu, G; Liu, Y; Pan, C; Ren, J; Yu, C	1
Fukumoto, K; Kamakura, S; Kato, R; Kitakaze, M; Kobayashi, T; Komamura, K; Tachibana, K; Tanaka, K; Ueno, K	1
Hollek, A; Loskot, M; Markiewicz-Łoskot, G; Moric-Janiszewska, E; Szydłowski, L; Weglarz, L	1
Cleland, JG; Di Lenarda, A; Komajda, M; Lukas, MA; Metra, M; Moullet, C; Poole-Wilson, PA; Remme, W; Scherhag, A; Spark, P; Swedberg, K; Torp-Pedersen, C	1
Aggarwal, K; Chockalingam, A; Dellsperger, KC; Tejwani, L	1
Fedorova, VI; Gordeev, SA; Nedostup, AV; Vasiukov, SS	1
Kapoor, JR	1
He, BB; Huang, GH; Lü, HS	1
Huang, ZJ; Li, T; Li, YL; Wu, YL; Yang, MQ	1
Hakala, T; Halonen, J; Halonen, P; Hartikainen, J; Hippeläinen, M; Järvinen, O; Karjalainen, J; Loponen, P; Magga, J; Parviainen, I; Turpeinen, A	1
Cole, JB; Engebretsen, KM; Fritzlar, SJ; Holger, JS; Stellpflug, SJ	1
Concannon, C; Li, VH; Li, VY; Mallick, A	1
Bailey, M; Chaudhuri, K; Krum, H; Kwa, LJ; Pick, AW; Rosenfeldt, FL; Skiba, MA	1
De Buyzere, M; De Pauw, M; Duytschaever, M; Van Heuverswyn, F	1
Erkut, B; Onk, OA	1
Czarnecka, D; Jastrzebski, M; Jurczyszyn, A; Olszanecka, A; Pizoń, T; Rajzer, M; Rojek, M; Wojciechowska, W	1
Ge, H; Jiang, H; Li, X; Liu, H	1
Celi, LA; Chahin, A; Chen, KP; Cooper, AZ; Ghassemi, MM; Moskowitz, A	1
Balik, M; Kolnikova, I; Kristof, J; Maly, M; Tavazzi, G; Waldauf, P	1
Hu, J; Li, J; Xia, Z; Yan, S; Yu, J; Zhu, B	1
Balik, M; Brestovansky, P; Brozek, T; Maly, M	1
Azzam, ZS; Khoury, J	1
Duan, H; Hua, Y; Li, Y; Lu, Y; Qiao, L; Wang, C; Yan, S; Zhou, K	1
Che, X; Fang, Y; Li, Y; Reis, C; Wang, H	1
Bessoudo, R; Faiella, W	1
Duan, X; Gui, Y; Jia, J; Li, S; Liu, CC; Liu, G; Lu, Y; Zhang, M	1
Irfan, M; Mohammad Aimanazrul, Z; Nik Hazlina, NH; Norhayati, MN; Shaiful Bahari, I; Zaharah, S	1
Busseuil, D; de Denus, S; Dubé, MP; Gaulin, MJ; Jutras, M; Leclair, G; Meloche, M; Mongrain, I; Oussaïd, E; Pilon, MO; Robert, S; Tardif, JC	1

Reviews

8 review(s) available for amiodarone and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
New antiarrhythmic drugs. American journal of surgery, 1983, Volume: 145, Issue:6 Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil	1983
Pharmacological rate control of atrial fibrillation. Cardiology clinics, 2004, Volume: 22, Issue:1 Topics: Amiodarone; Atenolol; Atrial Fibrillation; Cardiotonic Agents; Digoxin; Diltiazem; Heart Rate; Humans; Metoprolol; Randomized Controlled Trials as Topic; Verapamil	2004
A review of carvedilol arrhythmia data in clinical trials. Journal of cardiovascular pharmacology and therapeutics, 2005, Volume: 10 Suppl 1 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprolol; Carbazoles; Carvedilol; Death, Sudden, Cardiac; Digoxin; Heart Failure; Humans; Metoprolol; Myocardial Infarction; Propanolamines; Randomized Controlled Trials as Topic	2005
Dynamic left ventricular outflow tract obstruction in acute myocardial infarction with shock: cause, effect, and coincidence. Circulation, 2007, Jul-31, Volume: 116, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Algorithms; Amiodarone; Cardiac Catheterization; Diagnosis, Differential; Disease Management; Dopamine; Echocardiography, Doppler; Electrocardiography; Female; Heart Murmurs; Humans; Hypotension; Metoprolol; Mitral Valve Insufficiency; Motion; Myocardial Infarction; Shock, Cardiogenic; Systole; Ventricular Dysfunction, Left; Ventricular Outflow Obstruction	2007
[Efficacy and safety of amiodarone and metoprolol in the treatment of ventricular premature beats: a meta-analysis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2010, Volume: 30, Issue:11 Topics: Amiodarone; Drug Therapy, Combination; Humans; Metoprolol; Treatment Outcome; Ventricular Premature Complexes	2010
Antiarrhythmic drug-induced smell and taste disturbances: A case report and literature review. Medicine, 2018, Volume: 97, Issue:29 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dysgeusia; Female; Humans; Metoprolol; Olfaction Disorders; Smell; Taste	2018
Metoprolol for prophylaxis of postoperative atrial fibrillation in cardiac surgery patients: systematic review and meta-analysis. BMJ open, 2020, 10-31, Volume: 10, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Humans; Metoprolol; Postoperative Complications	2020

Trials

22 trial(s) available for amiodarone and metoprolol

Article	Year
A prospective study of the efficacy and safety of adjuvant metoprolol and xamoterol in combination with amiodarone for resistant ventricular tachycardia associated with impaired left ventricular function. American heart journal, 1992, Volume: 124, Issue:5 Topics: Adult; Aged; Amiodarone; Drug Therapy, Combination; Electrocardiography; Exercise Test; Female; Follow-Up Studies; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Prospective Studies; Stroke Volume; Tachycardia, Ventricular; Ventricular Function, Left; Xamoterol	1992
[Prospective long-term ECG study of 100 patients surviving sudden cardiac death]. Zeitschrift fur Kardiologie, 1992, Volume: 81, Issue:12 Topics: Adult; Aged; Amiodarone; Death, Sudden, Cardiac; Defibrillators, Implantable; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Rate; Heart Ventricles; Humans; Male; Metoprolol; Middle Aged; Propafenone; Tachycardia, Ventricular	1992
Adjuvant xamoterol or metoprolol in patients with malignant ventricular arrhythmia resistant to amiodarone. Lancet (London, England), 1989, Aug-05, Volume: 2, Issue:8658 Topics: Adrenergic beta-Agonists; Adult; Aged; Amiodarone; Drug Resistance; Drug Therapy, Combination; Electric Stimulation; Exercise Test; Female; Heart Ventricles; Humans; Male; Metoprolol; Middle Aged; Propanolamines; Random Allocation; Tachycardia; Xamoterol	1989
Effect of short and long term administration of amiodarone on ischaemia-induced left ventricular dysfunction. Implications for combined antianginal drug therapy. Drugs, 1985, Volume: 29 Suppl 3 Topics: Adult; Amiodarone; Angina Pectoris; Benzofurans; Coronary Disease; Female; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Nifedipine; Nitroglycerin	1985
Comparison of the effects of amiodarone versus metoprolol on the frequency of ventricular arrhythmias and on mortality after acute myocardial infarction. SSSD Investigators. Spanish Study on Sudden Death. The American journal of cardiology, 1993, Dec-01, Volume: 72, Issue:17 Topics: Aged; Amiodarone; Cardiac Complexes, Premature; Death, Sudden, Cardiac; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Spain; Statistics as Topic; Survival Analysis; Ventricular Function, Left	1993
ICD versus drugs in cardiac arrest survivors: preliminary results of the Cardiac Arrest Study Hamburg. Pacing and clinical electrophysiology : PACE, 1993, Volume: 16, Issue:3 Pt 2 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Defibrillators, Implantable; Female; Follow-Up Studies; Germany; Heart Arrest; Humans; Incidence; Male; Metoprolol; Middle Aged; Propafenone; Prospective Studies; Recurrence; Survival Rate; Tachycardia, Ventricular; Ventricular Fibrillation	1993
Implantable cardioverter defibrillator compared with antiarrhythmic drug treatment in cardiac arrest survivors (the Cardiac Arrest Study Hamburg). American heart journal, 1994, Volume: 127, Issue:4 Pt 2 Topics: Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Defibrillators, Implantable; Female; Heart Arrest; Humans; Incidence; Male; Metoprolol; Middle Aged; Propafenone; Prospective Studies; Risk Factors; Tachycardia, Ventricular; Ventricular Fibrillation	1994
Preliminary results of the Cardiac Arrest Study Hamburg (CASH). CASH Investigators. The American journal of cardiology, 1993, Nov-26, Volume: 72, Issue:16 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Death, Sudden, Cardiac; Defibrillators, Implantable; Female; Heart Arrest; Humans; Male; Metoprolol; Middle Aged; Multivariate Analysis; Propafenone; Prospective Studies; Regression Analysis; Tachycardia, Ventricular; Ventricular Fibrillation	1993
Randomized comparison of antiarrhythmic drug therapy with implantable defibrillators in patients resuscitated from cardiac arrest : the Cardiac Arrest Study Hamburg (CASH). Circulation, 2000, Aug-15, Volume: 102, Issue:7 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Female; Heart Arrest; Humans; Male; Metoprolol; Middle Aged; Resuscitation	2000
Amiodarone versus digoxin and metoprolol combination for the prevention of postcoronary bypass atrial fibrillation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2002, Volume: 21, Issue:3 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Coronary Artery Bypass; Digoxin; Drug Therapy, Combination; Female; Humans; Male; Metoprolol; Middle Aged; Postoperative Complications; Prospective Studies	2002
Shock on T versus direct current voltage for induction of ventricular fibrillation: a randomized prospective comparison. Pacing and clinical electrophysiology : PACE, 2004, Volume: 27, Issue:1 Topics: Amiodarone; Defibrillators, Implantable; Digoxin; Electric Countershock; Female; Humans; Lidocaine; Male; Metoprolol; Middle Aged; Prospective Studies; Ventricular Fibrillation	2004
Pharmacokinetic and pharmacodynamic interactions between metoprolol and dronedarone in extensive and poor CYP2D6 metabolizers healthy subjects. Fundamental & clinical pharmacology, 2004, Volume: 18, Issue:1 Topics: Adrenergic beta-Antagonists; Adult; Amiodarone; Anti-Arrhythmia Agents; Area Under Curve; Blood Pressure; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Dose-Response Relationship, Drug; Double-Blind Method; Dronedarone; Drug Interactions; Echocardiography; Electrocardiography; Genotype; Heart Rate; Hemodynamics; Humans; Male; Mass Spectrometry; Metoprolol; Polymorphism, Genetic	2004
A comparison between oral antiarrhythmic drugs in the prevention of atrial fibrillation after cardiac surgery: the pilot study of prevention of postoperative atrial fibrillation (SPPAF), a randomized, placebo-controlled trial. American heart journal, 2004, Volume: 147, Issue:4 Topics: Administration, Oral; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Logistic Models; Male; Metoprolol; Middle Aged; Pilot Projects; Postoperative Complications; Premedication; Sotalol	2004
Response to programmed ventricular stimulation and clinical outcome in cardiac arrest survivors receiving randomised assignment to implantable cardioverter defibrillator or antiarrhythmic drug therapy. European heart journal, 2004, Volume: 25, Issue:8 Topics: Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Electrophysiologic Techniques, Cardiac; Female; Heart Arrest; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Prospective Studies; Survival Analysis; Survivors; Treatment Outcome	2004
Effect of amiodarone and sotalol on ventricular defibrillation threshold: the optimal pharmacological therapy in cardioverter defibrillator patients (OPTIC) trial. Circulation, 2006, Jul-11, Volume: 114, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Bisoprolol; Carbazoles; Carvedilol; Combined Modality Therapy; Defibrillators, Implantable; Female; Heart Arrest; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Propanolamines; Sotalol; Ventricular Fibrillation; Ventricular Function, Left	2006
Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia. Drug metabolism and pharmacokinetics, 2006, Volume: 21, Issue:6 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Metoprolol; Middle Aged	2006
The safety of amiodarone in patients with heart failure. Journal of cardiac failure, 2007, Volume: 13, Issue:5 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Carbazoles; Carvedilol; Death, Sudden, Cardiac; Female; Heart Failure; Humans; Male; Metoprolol; Middle Aged; Multivariate Analysis; Propanolamines	2007
[New facts about pathogenesis of atrial fibrillation: correlation between changes in bioelectric brain activity and recurrence of atrial fibrillation paroxysms]. Terapevticheskii arkhiv, 2007, Volume: 79, Issue:9 Topics: Amiodarone; Anti-Arrhythmia Agents; Anticonvulsants; Atrial Fibrillation; Beta Rhythm; Brain; Clonazepam; Electroencephalography; Female; Humans; Male; Metoprolol; Middle Aged; Phenothiazines; Recurrence; Theta Rhythm	2007
[Therapeutic effects of amiodarone and metoprolol on chronic heart failure complicated by ventricular arrhythmia]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2009, Volume: 29, Issue:6 Topics: Adrenergic beta-Antagonists; Adult; Amiodarone; Anti-Arrhythmia Agents; Chronic Disease; Drug Therapy, Combination; Female; Heart Failure; Humans; Male; Metoprolol; Tachycardia, Ventricular; Treatment Outcome; Ventricular Premature Complexes	2009
Metoprolol versus amiodarone in the prevention of atrial fibrillation after cardiac surgery: a randomized trial. Annals of internal medicine, 2010, Dec-07, Volume: 153, Issue:11 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Female; Finland; Humans; Infusions, Intravenous; Male; Metoprolol; Middle Aged; Prospective Studies	2010
Prophylaxis against atrial fibrillation after cardiac surgery: beneficial effect of perioperative metoprolol. Heart, lung & circulation, 2013, Volume: 22, Issue:8 Topics: Administration, Oral; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Electrocardiography; Female; Humans; Male; Metoprolol; Middle Aged; Perioperative Care; Pilot Projects; Postoperative Complications; Prospective Studies; Time Factors	2013
Is the Preoperative Administration of Amiodarone or Metoprolol More Effective in Reducing Atrial Fibrillation: After Coronary Bypass Surgery? Medicine, 2015, Volume: 94, Issue:41 Topics: Age Factors; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Comorbidity; Coronary Artery Bypass; Female; Hospital Charges; Humans; Logistic Models; Male; Metoprolol; Middle Aged; Postoperative Complications; Preoperative Care; Prospective Studies; Risk Factors; Sex Factors	2015

Other Studies

53 other study(ies) available for amiodarone and metoprolol

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journal of medicinal chemistry, 2002, Dec-19, Volume: 45, Issue:26 Topics: Adenosine Triphosphatases; Algorithms; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Binding Sites; Binding, Competitive; Caco-2 Cells; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Fluoresceins; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rhodamine 123; Stereoisomerism; Verapamil; Vinblastine	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships. Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16 Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone	2016
[Multicenter clinical trial on the prevention of sudden death after myocardial infarction by the use of anti-arrhythmia agents. Investigator Group of the Spanish Study on Sudden Death]. Revista espanola de cardiologia, 1989, Volume: 42, Issue:2 Topics: Amiodarone; Arrhythmias, Cardiac; Captopril; Death, Sudden; Humans; Metoprolol; Multicenter Studies as Topic; Myocardial Infarction; Spain	1989
Amiodarone and beta-adrenergic blockers: an interaction with metoprolol but not with atenolol. American heart journal, 1988, Volume: 116, Issue:1 Pt 1 Topics: Amiodarone; Atenolol; Bradycardia; Cardiomyopathy, Hypertrophic; Drug Interactions; Drug Therapy, Combination; Female; Humans; Metoprolol; Middle Aged; Time Factors	1988
[Value of a serial electropharmacologic study in survivors of a cardiac arrest secondary to ventricular tachycardia or ventricular fibrillation]. Giornale italiano di cardiologia, 1984, Volume: 14, Issue:9 Topics: Adult; Aged; Amiodarone; Death, Sudden; Disopyramide; Drug Therapy, Combination; Electrocardiography; Female; Follow-Up Studies; Heart Arrest; Humans; Male; Metoprolol; Middle Aged; Pindolol; Propafenone; Propiophenones; Tachycardia; Ventricular Fibrillation	1984
[Prajmalium bitartrate in hyperkinetic ventricular arrhythmias in infarct patients during rehabilitation]. Giornale italiano di cardiologia, 1981, Volume: 11, Issue:6 Topics: Adult; Aged; Ajmaline; Ambulatory Care; Amiodarone; Arrhythmias, Cardiac; Drug Therapy, Combination; Electrocardiography; Female; Humans; Male; Metoprolol; Middle Aged; Monitoring, Physiologic; Myocardial Infarction; Prajmaline	1981
Amiodarone is a dose-dependent noncompetitive and competitive inhibitor of T3 binding to thyroid hormone receptor subtype beta 1, whereas disopyramide, lignocaine, propafenone, metoprolol, dl-sotalol, and verapamil have no inhibitory effect. Journal of cardiovascular pharmacology, 1995, Volume: 26, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Binding, Competitive; Disopyramide; Dose-Response Relationship, Drug; Humans; Lidocaine; Metoprolol; Propafenone; Receptors, Thyroid Hormone; Sotalol; Triiodothyronine; Verapamil	1995
[The effect of treatment with propafenone, metoprolol and amiodarone on lymphocyte sodium efflux and level of cAMP in serum]. Polskie Archiwum Medycyny Wewnetrznej, 1995, Volume: 94, Issue:1 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cyclic AMP; Female; Heart Diseases; Humans; Lymphocytes; Male; Metoprolol; Middle Aged; Propafenone; Sodium	1995
Circadian variation of sustained ventricular tachycardia in patients subject to standard adrenergic blockade. American heart journal, 1997, Volume: 134, Issue:4 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Circadian Rhythm; Female; Humans; Incidence; Male; Metoprolol; Middle Aged; Regression Analysis; Sotalol; Tachycardia, Ventricular	1997
Influence of beta-blockers on the frequency of arrhythmia recurrences in patients with implantable cardioverter-defibrillator: an intraindividual comparison. International journal of cardiology, 1998, Sep-01, Volume: 66, Issue:1 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Arrhythmias, Cardiac; Atenolol; Defibrillators, Implantable; Humans; Male; Metoprolol; Middle Aged; Recurrence	1998
Prospective clinical evaluation and follow-up of a cohort of consecutive VT/VF patients, using a staged-care protocol, including coronary arteriography, programmed electrical stimulation and cardiac surgery. Giornale italiano di cardiologia, 1999, Volume: 29, Issue:10 Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Cardiac Catheterization; Cardiac Surgical Procedures; Cohort Studies; Coronary Angiography; Coronary Artery Bypass; Coronary Disease; Defibrillators, Implantable; Electric Stimulation; Follow-Up Studies; Heart Aneurysm; Heart-Lung Transplantation; Humans; Metoprolol; Middle Aged; Prospective Studies; Sotalol; Tachycardia, Ventricular; Time Factors; Ventricular Fibrillation	1999
[Atrial fibrillation after open-heart surgery--incidence, prevention and treatment]. Orvosi hetilap, 2000, Oct-08, Volume: 141, Issue:41 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Electric Countershock; Female; Humans; Incidence; Male; Metoprolol; Middle Aged; Propafenone; Retrospective Studies; Treatment Outcome	2000
Absence of a morning peak in ventricular tachycardia and fibrillation events in nonischemic heart disease: analysis of therapies by implantable cardioverter defibrillators. Pacing and clinical electrophysiology : PACE, 2001, Volume: 24, Issue:11 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Circadian Rhythm; Defibrillators, Implantable; Female; Heart Diseases; Humans; Male; Metoprolol; Middle Aged; Myocardial Ischemia; Tachycardia, Ventricular; Ventricular Fibrillation	2001
Effectiveness of amiodarone therapy in patients with severe congestive heart failure and intolerance to metoprolol. The American journal of cardiology, 2002, Nov-01, Volume: 90, Issue:9 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Case-Control Studies; Drug Tolerance; Female; Follow-Up Studies; Heart Failure; Hemodynamics; Humans; Male; Metoprolol; Middle Aged; Prospective Studies; Severity of Illness Index; Stroke Volume; Treatment Outcome	2002
[Correction of baroreflex sensitivity impairment and efficacy of prevention of sudden arrhythmic death in patients with postinfarction left ventricular dysfunction]. Kardiologiia, 2004, Volume: 44, Issue:10 Topics: Adrenergic beta-Antagonists; Adult; Aged; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Antihypertensive Agents; Arrhythmias, Cardiac; Atenolol; Baroreflex; Bisoprolol; Carbazoles; Carvedilol; Data Interpretation, Statistical; Death, Sudden, Cardiac; Drug Therapy, Combination; Echocardiography; Electrocardiography; Female; Humans; Male; Metoprolol; Middle Aged; Myocardial Infarction; Perindopril; Phenylephrine; Propanolamines; Time Factors; Ventricular Dysfunction, Left	2004
Effect of amiodarone on the plasma levels of metoprolol. The American journal of cardiology, 2004, Nov-15, Volume: 94, Issue:10 Topics: Aged; Alleles; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cytochrome P-450 CYP2D6; Drug Interactions; Drug Therapy, Combination; Female; Genotype; Humans; Male; Metoprolol	2004
Salvage application of secondary blood cardioplegia in intractable ventricular fibrillation. Journal of cardiothoracic and vascular anesthesia, 2004, Volume: 18, Issue:5 Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Blood Gas Analysis; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electric Countershock; Electrocardiography; Female; Heart Arrest, Induced; Heart Septal Defects, Atrial; Heart Valve Prosthesis Implantation; Humans; Lidocaine; Magnesium Sulfate; Metoprolol; Mitral Valve; Postoperative Complications; Retreatment; Rheumatic Heart Disease; Ventricular Fibrillation	2004
Suppression by propranolol and amiodarone of an electrical storm refractory to metoprolol and amiodarone. International journal of cardiology, 2005, Mar-18, Volume: 99, Issue:2 Topics: Administration, Oral; Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Defibrillators, Implantable; Dose-Response Relationship, Drug; Drug Therapy, Combination; Equipment Failure; Follow-Up Studies; Heart Failure; Humans; Male; Metoprolol; Middle Aged; Propranolol; Recurrence; Tachycardia, Ventricular; Treatment Failure	2005
Effects of antiarrhythmic drug therapy on atrioventricular nodal function during atrial fibrillation in humans. Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2005, Volume: 7 Suppl 2 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrioventricular Node; Computer Simulation; Electrocardiography; Female; Humans; Male; Mathematics; Metoprolol; Middle Aged	2005
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Mar-01, Volume: 847, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil	2007
Arrhythmogenic right ventricular dysplasia:clinical study. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2007, Volume: 12, Issue:2 Topics: Adolescent; Amiodarone; Anti-Arrhythmia Agents; Arrhythmogenic Right Ventricular Dysplasia; Catheter Ablation; Combined Modality Therapy; Diagnosis, Differential; Echocardiography; Electrocardiography; Female; Humans; Lidocaine; Magnetic Resonance Imaging; Metoprolol	2007
Combination prophylactic therapy for post-operative atrial fibrillation. Journal of the American College of Cardiology, 2008, Jul-29, Volume: 52, Issue:5 Topics: Adrenergic beta-Antagonists; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Drug Therapy, Combination; Humans; Metoprolol; Postoperative Complications	2008
Cardiotoxic overdose treated with intravenous fat emulsion and high-dose insulin in the setting of hypertrophic cardiomyopathy. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:2 Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Amiodarone; Cardiomyopathy, Hypertrophic; Cardiotoxins; Diltiazem; Dose-Response Relationship, Drug; Drug Overdose; Drug Therapy, Combination; Fat Emulsions, Intravenous; Female; Humans; Hypoglycemic Agents; Insulin; Metoprolol; Suicide, Attempted; Treatment Outcome	2011
Wide complex tachycardia causing congestive heart failure. Pacing and clinical electrophysiology : PACE, 2011, Volume: 34, Issue:9 Topics: Amiodarone; Anti-Arrhythmia Agents; Bundle-Branch Block; Catheter Ablation; Cyclohexane Monoterpenes; Defibrillators, Implantable; Electrocardiography; Female; Heart Failure; Humans; Lisinopril; Metoprolol; Middle Aged; Monoterpenes; Procainamide; Tachycardia; Treatment Outcome	2011
Chronotropic incompetence: real life observations of a theoretical concept. Acta cardiologica, 2013, Volume: 68, Issue:2 Topics: Adrenergic beta-1 Receptor Antagonists; Amiodarone; Anti-Arrhythmia Agents; Carbazoles; Carvedilol; Exercise Test; Exercise Tolerance; Female; Heart Failure; Heart Rate; Humans; Male; Metoprolol; Middle Aged; Propanolamines; Vasodilator Agents	2013
[Hypertrophic cardiomyopathy with midventricular obstruction of the left ventricle (MVO)--case report]. Przeglad lekarski, 2015, Volume: 72, Issue:5 Topics: Aged; Amiodarone; Cardiomyopathy, Hypertrophic; Defibrillators, Implantable; Female; Heart Ventricles; Humans; Metoprolol; Treatment Outcome; Ultrasonography; Ventricular Outflow Obstruction	2015
Predictors of Pharmacological Therapy of Ectopic Atrial Tachycardia in Children. Pediatric cardiology, 2017, Volume: 38, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathies; Child; Child, Preschool; China; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infant; Logistic Models; Male; Metoprolol; Multivariate Analysis; Propafenone; Retrospective Studies; Sotalol; Tachycardia, Ectopic Atrial; Treatment Outcome	2017
Management of Atrial Fibrillation with Rapid Ventricular Response in the Intensive Care Unit: A Secondary Analysis of Electronic Health Record Data. Shock (Augusta, Ga.), 2017, Volume: 48, Issue:4 Topics: Aged; Aged, 80 and over; Amiodarone; Atrial Fibrillation; Critical Care; Databases, Factual; Diltiazem; Disease-Free Survival; Electronic Health Records; Female; Humans; Male; Metoprolol; Middle Aged; Survival Rate	2017
Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol. Journal of critical care, 2017, Volume: 41 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Critical Care; Electric Countershock; Female; Humans; Male; Metoprolol; Middle Aged; Propafenone; Retrospective Studies; Shock, Septic; Tachycardia, Supraventricular; Treatment Outcome	2017
A rare form of extremely wide QRS complex due to reversed homologous electrical ventricular separation of acute heart failure. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2018, Volume: 23, Issue:1 Topics: Acute Disease; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Anti-Arrhythmia Agents; Benzazepines; Diuretics; Electric Countershock; Electrocardiography; Furosemide; Heart Failure; Heart Valve Diseases; Heart Ventricles; Humans; Male; Metoprolol; Middle Aged; Pacemaker, Artificial; Spironolactone; Tachycardia, Ventricular	2018
Reply. Journal of critical care, 2018, Volume: 45 Topics: Amiodarone; Arrhythmias, Cardiac; Humans; Metoprolol; Propafenone; Shock, Septic	2018
Propafenone for supraventricular arrhythmias in septic shock-Comparison to amiodarone and metoprolol. Journal of critical care, 2018, Volume: 45 Topics: Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Humans; Metoprolol; Propafenone; Shock, Septic	2018
A delayed diagnosis of catecholaminergic polymorphic ventricular tachycardia with a mutant of RYR2 at c.7580T>G for 6 years in a 9-year-old child. Medicine, 2018, Volume: 97, Issue:16 Topics: Amiodarone; Anti-Arrhythmia Agents; Child; Death, Sudden, Cardiac; Delayed Diagnosis; Electrocardiography; Exercise Test; Genetic Testing; Humans; Male; Metoprolol; Mutation; Physical Exertion; Propafenone; Ryanodine Receptor Calcium Release Channel; Syncope; Tachycardia, Ventricular	2018
Cardiac manifestations in Emery-Dreifuss muscular dystrophy. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2018, 12-03, Volume: 190, Issue:48 Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Defibrillators, Implantable; Electric Countershock; Electrocardiography; Humans; Male; Metoprolol; Muscular Dystrophy, Emery-Dreifuss; Stroke Volume; Tachycardia, Ventricular	2018
Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring. Scientific reports, 2020, 09-23, Volume: 10, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Computer Systems; Diltiazem; Drug Monitoring; Humans; Metoprolol; Pharmaceutical Preparations; Propafenone; Tandem Mass Spectrometry; Verapamil	2020
Impact of amiodarone use on metoprolol concentrations, α-OH-metoprolol concentrations, metoprolol dosing and heart rate: A cross-sectional study. Pharmacology research & perspectives, 2023, Volume: 11, Issue:5 Topics: Adult; Amiodarone; Bradycardia; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; Heart Rate; Humans; Metoprolol	2023