amiodarone and diltiazem

amiodarone has been researched along with diltiazem in 82 studies

Research

Studies (82)

Timeframe	Studies, this research(%)	All Research%
pre-1990	10 (12.20)	18.7374
1990's	6 (7.32)	18.2507
2000's	41 (50.00)	29.6817
2010's	20 (24.39)	24.3611
2020's	5 (6.10)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Keserü, GM	1
Cianchetta, G; Cruciani, G; Fravolini, A; Giesing, D; Singleton, RW; Vaz, RJ; Wildgoose, M; Zhang, M	1
Nagashima, R; Nishikawa, T; Tobita, M	1
Li, Y; Li, YH; Wang, YH; Yang, L; Yang, SL	1
Dansette, PM; Fontana, E; Poli, SM	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Evans, CA; Jolivette, LJ; Nagilla, R; Ward, KW	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Jia, L; Sun, H	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Cooper, J; Cui, Y; Fink, M; Gavaghan, DJ; Heath, BM; McMahon, NC; Mirams, GR; Noble, D; Sher, A	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Dalvie, D; Loi, CM; Smith, DA	1
Brown, AM; Bruening-Wright, A; Kramer, J; Kuryshev, YA; Myatt, G; Obejero-Paz, CA; Verducci, JS	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Broustet, JP; Douard, H; Mora, B	1
Gonzalez-Sicilia, L; Hernandez, J; Laorden, ML; Perez, D; Villalobos, JP	1
Gueron, M; Kracoff, OH; Ovsyshcher, I	1
Schwartz, PJ; Vanoli, E	1
Eloy, JP; Lesbre, JP	1
Antman, EM; Friedman, PL; Goldman, L; Lee, TH; Stone, PH	1
Hess, DS; Scheinman, MM	1
Bertrand, ME; Lablanche, JM; Thieuleux, FA; Tilmant, PY	1
Alegría, E; Arcas, R; Barba, J; Llorens, R; Malpartida, F; Martín Trenor, A	1
Barnay, C; Hanvic, G; Medvedowsky, JL	1
Decrinis, M; Kasper, K; Schulze-Bauer, C; Stark, G; Stark, U; Tritthart, HA	2
Fledelius, HC; Thystrup, JD	1
Bataller, M; Chorro, FJ; Cortina, J; Espí, J; Guerrero, J; López-Merino, V; Ruipérez, JA; Sánchez-Muñoz, JJ; Sanchis, J	1
Steinbeck, G	1
Hohnloser, SH; Kuck, KH	2
Cleland, JG; Kaye, GC; Khand, AU; Rankin, AC	1
Capucci, A; Piepoli, MF; Terracciano, C; Villani, GQ	1
Hohnloser, SH; Kuck, KH; Lilienthal, J	1
Landwojtowicz, E; Seelig, A	1
Harrison, RA; Liratsopulos, G	1
Hohnloser, SH	1
Delle Karth, G; Geppert, A; Gschwandtner, M; Haumer, M; Heinz, G; Neunteufl, T; Priglinger, U; Siostrzonek, P	1
Bruckman, D; Decena, BF; Eagle, KA; Kim, MH; McHale, C; Morady, F; Rachwal, W; Russman, P	1
Cieśliński, A; Grajek, S; Grygier, M; Mularek-Kubzdela, T; Seniuk, W	1
Kanorskiĭ, SG; Zingilevskiĭ, KB	1
Curtis, AB; Saxonhouse, SJ	1
Dermitzaki, DN; Kallergis, EM; Kambouraki, DC; Kanoupakis, EM; Manios, EG; Mavrakis, HE; Vardas, PE	1
Nattel, S	1
Kohno, Y; Suzuki, A; Yamamoto, T	1
Bass, EB; Tamariz, LJ	1
Freestone, B; Kamath, S; Lip, G	1
Freestone, B; Lip, GY	2
Holmes, EC; Samuels, FL; Samuels, LE	1
Bougioukas, G; Didilis, V; Konstantinou, F; Mikroulis, D; Tsakiridis, K; Vretzakis, G	1
Lip, GY	1
Ampollini, L; Bettati, S; Bobbio, A; Caporale, D; Carbognani, P; Internullo, E; Rossini, E; Rusca, M	1
Cai, Y; Jia, J; Li, S; Liu, G; Liu, Y; Pan, C; Ren, J; Yu, C	1
Aytekin, S; Aytekin, V; Men, EE; Tuğcu, A; Yildirimtürk, O	1
Lam, KF; Lau, CP; Lee, WL; Siu, CW; Tse, HF	1
González Oliva, JC; Pou Potau, M; Ramírez de Arellano Serna, M; Salas Gama, KR; Saurina i Solé, A	1
Globits, S; Hirschl, MM; Wollmann, C	1
Becker, R; Katus, HA; Li, J; Zitron, E	1
Cole, JB; Engebretsen, KM; Fritzlar, SJ; Holger, JS; Stellpflug, SJ	1
Shen, SL; Zhao, YC	1
Drożdż, J; Filipiak, KJ; Grajek, S; Kasprzak, JD; Opolski, G; Rynkiewicz, A; Stępińska, J; Tykarski, A; Wożakowska Kapłon, B	1
Belardinelli, L; Machado, AD; Nearing, BD; Sobrado, LF; Varone, BB; Verrier, RL; Zeng, D	1
Celi, LA; Chahin, A; Chen, KP; Cooper, AZ; Ghassemi, MM; Moskowitz, A	1
Duan, X; Gui, Y; Jia, J; Li, S; Liu, CC; Liu, G; Lu, Y; Zhang, M	1
Blackwood, B; Chean, CS; Duarte, R; Hill, R; Johnston, BW; McAuley, DF; Welters, ID	1
Ainsworth, M; Bookstaver, D; Gleaton, M; Milner, E	1
Bando, Y; Ishii, H; Otori, K; Yokota, N	1
Ainsworth, M; Bookstaver, DA; Gleaton, M; Milner, E	1

Reviews

15 review(s) available for amiodarone and diltiazem

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
New antiarrhythmic drugs. American journal of surgery, 1983, Volume: 145, Issue:6 Topics: Amiodarone; Angina Pectoris; Anti-Arrhythmia Agents; Blood Circulation; Bradycardia; Diltiazem; Half-Life; Humans; Hypertension; Lidocaine; Metoprolol; Nadolol; Nifedipine; Propanolamines; Propranolol; Tocainide; Verapamil	1983
[Treatment of coronary arterial spasm]. Revista de medicina de la Universidad de Navarra, 1982, Volume: 26, Issue:2 Topics: Amiodarone; Coronary Vasospasm; Denervation; Diltiazem; Humans; Isosorbide Dinitrate; Myocardial Revascularization; Nifedipine; Nitroglycerin; Phenoxybenzamine; Phentolamine; Reserpine; Verapamil	1982
[Drug therapy of atrial fibrillation: control of heart rate versus establishing sinus rhythm]. Zeitschrift fur Kardiologie, 1996, Volume: 85 Suppl 6 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Diltiazem; Electric Countershock; Electrocardiography; Heart Rate; Humans; Survival Rate; Treatment Outcome	1996
Systematic review of the management of atrial fibrillation in patients with heart failure. European heart journal, 2000, Volume: 21, Issue:8 Topics: Acute Disease; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Chronic Disease; Clinical Trials as Topic; Digoxin; Diltiazem; Electric Countershock; Heart Failure; Humans; Retrospective Studies	2000
Atrial fibrillation: is rate stabilization a valid clinical strategy? Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2001, Volume: 6, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Clinical Protocols; Diltiazem; Heart Rate; Humans; Morbidity; Patient Selection; Risk Factors; Treatment Outcome	2001
Risks and benefits of rate control versus maintenance of sinus rhythm. The American journal of cardiology, 2003, Mar-20, Volume: 91, Issue:6A Topics: Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Atrial Fibrillation; Clinical Trials as Topic; Diltiazem; Heart Conduction System; Heart Rate; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Recurrence; Stroke; Therapeutic Equivalency	2003
Pharmacological rate control of atrial fibrillation. Cardiology clinics, 2004, Volume: 22, Issue:1 Topics: Amiodarone; Atenolol; Atrial Fibrillation; Cardiotonic Agents; Digoxin; Diltiazem; Heart Rate; Humans; Metoprolol; Randomized Controlled Trials as Topic; Verapamil	2004
Atrial fibrillation (acute). Clinical evidence, 2003, Issue:9 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Humans; Timolol; Verapamil	2003
Atrial fibrillation (acute). Clinical evidence, 2003, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Timolol; Verapamil	2003
Selective use of amiodarone and early cardioversion for postoperative atrial fibrillation. The Annals of thoracic surgery, 2005, Volume: 79, Issue:1 Topics: Administration, Oral; Adrenergic beta-Antagonists; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Combined Modality Therapy; Coronary Artery Bypass; Digoxin; Diltiazem; Drug Therapy, Combination; Electric Countershock; Female; Humans; Infusions, Intravenous; Injections, Intravenous; Length of Stay; Male; Middle Aged; Postoperative Complications; Procainamide; Retrospective Studies; Treatment Outcome	2005
Atrial fibrillation (acute). Clinical evidence, 2004, Issue:11 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil	2004
Atrial fibrillation (recent onset). Clinical evidence, 2005, Issue:14 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Flecainide; Humans; Propafenone; Verapamil	2005
Management of new onset atrial fibrillation in critically unwell adult patients: a systematic review and narrative synthesis. British journal of anaesthesia, 2022, Volume: 128, Issue:5 Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Diltiazem; Electric Countershock; Humans; Magnesium	2022

Trials

10 trial(s) available for amiodarone and diltiazem

Article	Year
Atrial fibrillation: maintaining stability of sinus rhythm or ventricular rate control? The need for prospective data: the PIAF trial. Pacing and clinical electrophysiology : PACE, 1997, Volume: 20, Issue:8 Pt 1 Topics: Adolescent; Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Diltiazem; Electric Countershock; Female; Germany; Heart Rate; Humans; Male; Middle Aged; Multicenter Studies as Topic; Prospective Studies; Randomized Controlled Trials as Topic; Research Design	1997
Effects of diltiazem pretreatment on direct-current cardioversion in patients with persistent atrial fibrillation: a single-blind, randomized, controlled study. American heart journal, 2000, Volume: 140, Issue:3 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Diltiazem; Electric Countershock; Female; Humans; Male; Middle Aged; Premedication; Recurrence; Single-Blind Method; Treatment Outcome	2000
Rhythm or rate control in atrial fibrillation--Pharmacological Intervention in Atrial Fibrillation (PIAF): a randomised trial. Lancet (London, England), 2000, Nov-25, Volume: 356, Issue:9244 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Diltiazem; Electric Countershock; Follow-Up Studies; Heart Rate; Hospitalization; Humans; Middle Aged; Physical Exertion; Quality of Life	2000
Amiodarone versus diltiazem for rate control in critically ill patients with atrial tachyarrhythmias. Critical care medicine, 2001, Volume: 29, Issue:6 Topics: Aged; Amiodarone; Analysis of Variance; Anti-Arrhythmia Agents; APACHE; Atrial Fibrillation; Atrial Flutter; Calcium Channel Blockers; Chi-Square Distribution; Critical Illness; Diltiazem; Female; Heart Rate; Humans; Intensive Care Units; Male; Prospective Studies; Treatment Outcome	2001
Effects of amiodarone and diltiazem on persistent atrial fibrillation conversion and recurrence rates: a randomized controlled study. Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:1 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Calcium Channels, L-Type; Chronic Disease; Diltiazem; Electric Countershock; Electrophysiologic Techniques, Cardiac; Female; Humans; Male; Middle Aged; Prospective Studies; Secondary Prevention	2003
Diltiazem versus amiodarone to prevent atrial fibrillation in coronary surgery. Asian cardiovascular & thoracic annals, 2005, Volume: 13, Issue:1 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Coronary Artery Bypass; Diltiazem; Extracorporeal Circulation; Female; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Prospective Studies; Ventricular Fibrillation	2005
Postoperative outcome of patients undergoing lung resection presenting with new-onset atrial fibrillation managed by amiodarone or diltiazem. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2007, Volume: 31, Issue:1 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Diltiazem; Female; Humans; Male; Middle Aged; Pneumonectomy; Postoperative Care; Prospective Studies; Recurrence; Treatment Outcome	2007
[The comparison between the efficiency of different anti-arrhythmic agents in preventing postoperative atrial fibrillation after open heart surgery]. Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology, 2008, Volume: 8, Issue:3 Topics: Administration, Oral; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cardiac Surgical Procedures; Diltiazem; Female; Humans; Incidence; Length of Stay; Male; Middle Aged; Postoperative Complications; Propafenone; Prospective Studies; Single-Blind Method; Sotalol; Treatment Outcome; Turkey	2008
Intravenous diltiazem is superior to intravenous amiodarone or digoxin for achieving ventricular rate control in patients with acute uncomplicated atrial fibrillation. Critical care medicine, 2009, Volume: 37, Issue:7 Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Cohort Studies; Digoxin; Diltiazem; Female; Humans; Infusions, Intravenous; Length of Stay; Male; Middle Aged; Tachycardia, Ventricular; Treatment Outcome	2009
[A comparative study on the efficacy and safety of intravenous esmolol, amiodarone and diltiazem for controlling rapid ventricular rate of patients with atrial fibrillation during anesthesia period]. Zhonghua xin xue guan bing za zhi, 2010, Volume: 38, Issue:11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Anesthesia; Atrial Fibrillation; Child; Diltiazem; Female; Heart Rate; Humans; Male; Middle Aged; Propanolamines; Treatment Outcome; Young Adult	2010

Other Studies

57 other study(ies) available for amiodarone and diltiazem

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters, 2003, Aug-18, Volume: 13, Issue:16 Topics: Cation Transport Proteins; Databases, Factual; Discriminant Analysis; Ether-A-Go-Go Potassium Channels; Holography; Linear Models; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quantitative Structure-Activity Relationship	2003
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR. Journal of medicinal chemistry, 2005, Apr-21, Volume: 48, Issue:8 Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Caco-2 Cells; Fluoresceins; Fluorescent Dyes; Humans; Models, Molecular; Multivariate Analysis; Permeability; Quantitative Structure-Activity Relationship	2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors. Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11 Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated	2005
Modeling K(m) values using electrotopological state: substrates for cytochrome P450 3A4-mediated metabolism. Bioorganic & medicinal chemistry letters, 2005, Sep-15, Volume: 15, Issue:18 Topics: Computational Biology; Cyclohexanols; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Molecular Structure; Principal Component Analysis; Pyrrolizidine Alkaloids; Quantitative Structure-Activity Relationship; Reproducibility of Results; Substrate Specificity; Venlafaxine Hydrochloride	2005
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Extrapolation of preclinical pharmacokinetics and molecular feature analysis of "discovery-like" molecules to predict human pharmacokinetics. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:7 Topics: Animals; Biometry; Dogs; Drug Evaluation, Preclinical; Haloperidol; Haplorhini; Humans; Injections, Intravenous; Liver; Liver Circulation; Metabolic Clearance Rate; Mifepristone; Molecular Structure; Molecular Weight; Rats; Reproducibility of Results	2006
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Support vector machines classification of hERG liabilities based on atom types. Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11 Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Chemical; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Predictive Value of Tests; ROC Curve	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk. Cardiovascular research, 2011, Jul-01, Volume: 91, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Computer Simulation; Dogs; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Guinea Pigs; HEK293 Cells; Humans; Ion Channels; Kinetics; Models, Cardiovascular; NAV1.5 Voltage-Gated Sodium Channel; Patch-Clamp Techniques; Potassium Channel Blockers; Rabbits; Risk Assessment; Risk Factors; Sodium Channel Blockers; Sodium Channels; Torsades de Pointes; Transfection	2011
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Which metabolites circulate? Drug metabolism and disposition: the biological fate of chemicals, 2013, Volume: 41, Issue:5 Topics: Humans; Metabolic Clearance Rate; Pharmaceutical Preparations	2013
MICE models: superior to the HERG model in predicting Torsade de Pointes. Scientific reports, 2013, Volume: 3 Topics: ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Theoretical; Patch-Clamp Techniques; Predictive Value of Tests; Torsades de Pointes	2013
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Use of drugs in cardiac rehabilitation. Bibliotheca cardiologica, 1986, Issue:40 Topics: Adrenergic beta-Antagonists; Amiodarone; Diltiazem; Drug Therapy, Combination; Electrocardiography; Exercise Test; Heart Diseases; Humans; Middle Aged; Nifedipine; Nitrates; Nitroglycerin; Physical Exertion; Verapamil	1986
Compared efficacy of quinidine, amiodarone and diltiazem on both nomotopic and ectopic automaticity in the rat heart. Methods and findings in experimental and clinical pharmacology, 1987, Volume: 9, Issue:1 Topics: Amiodarone; Animals; Atrial Function; Diltiazem; Female; Heart Atria; Heart Rate; Heart Ventricles; In Vitro Techniques; Male; Quinidine; Rats; Rats, Inbred Strains; Ventricular Function	1987
Malignant course of a benign anomaly: myocardial bridging. Chest, 1987, Volume: 92, Issue:6 Topics: Adult; Amiodarone; Cardiomyopathies; Coronary Angiography; Diltiazem; Electrocardiography; Electrophysiology; Humans; Male; Syncope; Tachycardia	1987
An experimental approach to the choice of antiarrhythmic therapy. European heart journal, 1986, Volume: 7 Suppl A Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cats; Coronary Disease; Diltiazem; Lidocaine; Mexiletine; Nifedipine; Phenoxybenzamine; Prazosin; Propafenone; Propiophenones; Propranolol; Stellate Ganglion; Verapamil	1986
An open comparison of amiodarone with diltiazem and glyceryl trinitrate in patients with stable exertional angina. Drugs, 1985, Volume: 29 Suppl 3 Topics: Aged; Amiodarone; Angina Pectoris; Benzazepines; Benzofurans; Diltiazem; Electrocardiography; Female; Humans; Male; Middle Aged; Nitroglycerin; Physical Exertion	1985
Sinus arrest and hypotension with combined amiodarone-diltiazem therapy. American heart journal, 1985, Volume: 109, Issue:1 Topics: Amiodarone; Benzazepines; Benzofurans; Diltiazem; Drug Interactions; Drug Therapy, Combination; Female; Heart Failure; Humans; Hypotension; Middle Aged; Myocardial Contraction; Sinoatrial Node	1985
[Strategy of the treatment of vasospastic angina pectoris]. Archives des maladies du coeur et des vaisseaux, 1983, Volume: 76 Spec No Topics: Adult; Amiodarone; Angina Pectoris, Variant; Arteriosclerosis; Coronary Artery Bypass; Coronary Vasospasm; Diltiazem; Humans; Middle Aged; Nifedipine; Nitroglycerin; Radiography; Verapamil	1983
[Treatment of unstable angina pectoris with combined amiodarone-diltiazem]. Annales de cardiologie et d'angeiologie, 1982, Volume: 31, Issue:4 Topics: Adult; Aged; Amiodarone; Angina Pectoris; Benzazepines; Benzofurans; Diltiazem; Drug Therapy, Combination; Drug Tolerance; Female; Follow-Up Studies; Humans; Male; Middle Aged	1982
Comparison of the frequency-dependent effects on the atrioventricular node of verapamil, amiodarone, digoxin, and diltiazem in isolated guinea pig hearts. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:2 Topics: Amiodarone; Animals; Atrioventricular Node; Cardiac Pacing, Artificial; Computer Simulation; Digoxin; Diltiazem; Electric Stimulation; Electrocardiography; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Verapamil	1995
Retinal maculopathy possibly associated with amiodarone medication. Acta ophthalmologica, 1994, Volume: 72, Issue:5 Topics: Amiodarone; Diltiazem; Female; Fundus Oculi; Humans; Laser Therapy; Middle Aged; Retina; Retinal Diseases; Tachycardia, Paroxysmal; Triazolam; Visual Acuity	1994
How to measure AV nodal refractoriness in the presence of verapamil, amiodarone, digoxin, and diltiazem. Pacing and clinical electrophysiology : PACE, 1996, Volume: 19, Issue:2 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Cardiac Pacing, Artificial; Digoxin; Diltiazem; Electrocardiography; Female; Fourier Analysis; Guinea Pigs; Heart Rate; Male; Signal Processing, Computer-Assisted; Verapamil	1996
Modifications in the evolution of the dominant frequency in ventricular fibrillation induced by amiodarone, diltiazem, and flecainide. An experimental study. Journal of electrocardiology, 1996, Volume: 29, Issue:4 Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Diltiazem; Dogs; Electrocardiography; Flecainide; Fourier Analysis; Signal Processing, Computer-Assisted; Time Factors; Ventricular Fibrillation	1996
Structure-activity relationship of P-glycoprotein substrates and modifiers. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2000, Volume: 12, Issue:1 Topics: Adenosine Triphosphatases; Amiodarone; Amitriptyline; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; CHO Cells; Colchicine; Cricetinae; Cyclosporine; Daunorubicin; Diltiazem; Kinetics; Micelles; Progesterone; Propranolol; Structure-Activity Relationship; Verapamil; Vinblastine	2000
Atrial fibrillation control and cardioversion. Lancet (London, England), 2001, Apr-07, Volume: 357, Issue:9262 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Diltiazem; Electric Countershock; Humans; Treatment Outcome	2001
Randomized trial of rhythm or rate control in atrial fibrillation: the Pharmacological Intervention in Atrial Fibrillation Trial (PIAF). European heart journal, 2001, Volume: 22, Issue:10 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Diltiazem; Heart Rate; Humans; Randomized Controlled Trials as Topic; Vasodilator Agents	2001
Effect of amiodarone +/- diltiazem +/- beta blocker on frequency of atrial fibrillation, length of hospitalization, and hospital costs after coronary artery bypass grafting. The American journal of cardiology, 2002, May-01, Volume: 89, Issue:9 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Atrial Fibrillation; Coronary Artery Bypass; Coronary Disease; Critical Pathways; Diltiazem; Drug Therapy, Combination; Female; Hospital Costs; Humans; Incidence; Length of Stay; Male; Middle Aged; Outcome Assessment, Health Care; Postoperative Period; Preoperative Care; Vasodilator Agents	2002
Cardiac arrest related to coronary spasm in patients with variant angina: a three-case study. Journal of internal medicine, 2002, Volume: 252, Issue:4 Topics: Amiodarone; Angina Pectoris, Variant; Anti-Arrhythmia Agents; Aspirin; Calcium Channel Blockers; Cardiovascular Agents; Coronary Angiography; Diltiazem; Electrocardiography; Female; Follow-Up Studies; Heart Arrest; Heart Block; Humans; Male; Middle Aged; Nitrates; Nitroglycerin; Pacemaker, Artificial; Platelet Aggregation Inhibitors; Spasm; Time Factors; Vasodilator Agents; Ventricular Fibrillation	2002
[Comparative effects of amiodarone, diltiazem, and atenolol on results of electrical cardioversion in patients with chronic atrial fibrillation]. Kardiologiia, 2002, Volume: 42, Issue:8 Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Atenolol; Atrial Fibrillation; Chronic Disease; Diltiazem; Electric Countershock; Female; Humans; Male; Middle Aged; Treatment Outcome	2002
Drugs to promote sinus rhythm reversion and maintenance in atrial fibrillation--why amiodarone is better. Cardiovascular drugs and therapy, 2003, Volume: 17, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Calcium Channel Blockers; Diltiazem; Electric Countershock; Humans; Randomized Controlled Trials as Topic	2003
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:1 Topics: Amiodarone; Animals; Baculoviridae; Binding, Competitive; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Diltiazem; Enzyme Inhibitors; Fluorescence; Humans; Inhibitory Concentration 50; Ketoconazole; Miconazole; Midazolam; Propafenone; Quinolines; Recombinant Proteins; Troleandomycin; Verapamil	2004
Simultaneous determination of ten antiarrhythic drugs and a metabolite in human plasma by liquid chromatography--tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2007, Mar-01, Volume: 847, Issue:2 Topics: Amiodarone; Anti-Arrhythmia Agents; Atenolol; Bisoprolol; Carbazoles; Carvedilol; Chromatography, Liquid; Diltiazem; Humans; Metoprolol; Mexiletine; Molecular Structure; Propanolamines; Propranolol; Reproducibility of Results; Sotalol; Tandem Mass Spectrometry; Verapamil	2007
[Difficult-to-treat atrial fibrillation in a patient on haemodialysis]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2010, Volume: 30, Issue:2 Topics: Adrenergic beta-Antagonists; Aged; Amiodarone; Atrial Fibrillation; Bisoprolol; Bradycardia; Calcium Channel Blockers; Cardiovascular Agents; Combined Modality Therapy; Digoxin; Diltiazem; Female; Humans; Hypothyroidism; Kidney Failure, Chronic; Myocardial Infarction; Pacemaker, Artificial; Renal Dialysis	2010
A 2-year survey of treatment of acute atrial fibrillation in an ED. The American journal of emergency medicine, 2011, Volume: 29, Issue:5 Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Digoxin; Diltiazem; Emergency Service, Hospital; Female; Flecainide; Humans; Male; Middle Aged; Sulfonamides; Time Factors; Treatment Outcome	2011
PMS: premenstrual storm? An unusual cause of electrical storm in a young woman with vasospastic angina. Clinical research in cardiology : official journal of the German Cardiac Society, 2011, Volume: 100, Issue:4 Topics: Adult; Amiodarone; Angina Pectoris, Variant; Biomarkers; Defibrillators, Implantable; Diltiazem; Drug Therapy, Combination; Electrocardiography; Female; Heart Arrest; Humans; Lorazepam; Natriuretic Peptide, Brain; Pentaerythritol Tetranitrate; Peptide Fragments; Premenstrual Syndrome; Tachycardia, Ventricular; Troponin T; Vasodilator Agents	2011
Cardiotoxic overdose treated with intravenous fat emulsion and high-dose insulin in the setting of hypertrophic cardiomyopathy. Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2011, Volume: 7, Issue:2 Topics: Adrenergic beta-1 Receptor Antagonists; Adult; Amiodarone; Cardiomyopathy, Hypertrophic; Cardiotoxins; Diltiazem; Dose-Response Relationship, Drug; Drug Overdose; Drug Therapy, Combination; Fat Emulsions, Intravenous; Female; Humans; Hypoglycemic Agents; Insulin; Metoprolol; Suicide, Attempted; Treatment Outcome	2011
[Optimum heart rate - the current goal of cardiovascular therapy. Position statement of the Polish Cardiac Society Working Group on Cardiovascular Drug Therapy]. Kardiologia polska, 2012, Volume: 70, Issue:10 Topics: Adrenergic beta-Agonists; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzazepines; Digoxin; Diltiazem; Heart Diseases; Heart Rate; Humans; Hypertension; Ivabradine; Verapamil	2012
Dronedarone's inhibition of If current is the primary mechanism responsible for its bradycardic effect. Journal of cardiovascular electrophysiology, 2013, Volume: 24, Issue:8 Topics: Amiodarone; Analysis of Variance; Animals; Arterial Pressure; Benzazepines; Blood Pressure; Bradycardia; Diltiazem; Dronedarone; Isoproterenol; Ivabradine; Myocardial Contraction; Swine	2013
Management of Atrial Fibrillation with Rapid Ventricular Response in the Intensive Care Unit: A Secondary Analysis of Electronic Health Record Data. Shock (Augusta, Ga.), 2017, Volume: 48, Issue:4 Topics: Aged; Aged, 80 and over; Amiodarone; Atrial Fibrillation; Critical Care; Databases, Factual; Diltiazem; Disease-Free Survival; Electronic Health Records; Female; Humans; Male; Metoprolol; Middle Aged; Survival Rate	2017
Direct analysis in real time-mass spectrometry for rapid quantification of five anti-arrhythmic drugs in human serum: application to therapeutic drug monitoring. Scientific reports, 2020, 09-23, Volume: 10, Issue:1 Topics: Amiodarone; Anti-Arrhythmia Agents; Chromatography, High Pressure Liquid; Computer Systems; Diltiazem; Drug Monitoring; Humans; Metoprolol; Pharmaceutical Preparations; Propafenone; Tandem Mass Spectrometry; Verapamil	2020
Assessment of Anti-Xa activity in patients receiving concomitant apixaban with strong p-glycoprotein inhibitors and statins. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:5 Topics: Adult; Aged; Amiodarone; Atorvastatin; ATP Binding Cassette Transporter, Subfamily B; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Diltiazem; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Middle Aged; Pyrazoles; Pyridones; Rosuvastatin Calcium; Simvastatin	2022
[Significant Prolongation of the International Normalized Ratio Associated with COVID-19 Treatment: Possible Drug Interaction with Remdesivir]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2022, Volume: 142, Issue:10 Topics: Adenosine Monophosphate; Alanine; Amiodarone; Anticoagulants; Atorvastatin; Bisoprolol; COVID-19 Drug Treatment; Dexamethasone; Diltiazem; Drug Interactions; Humans; International Normalized Ratio; Male; Middle Aged; Warfarin	2022
A Real-World Matched Cohort Study of the Effect of Concomitant Amiodarone or Diltiazem Administration on Apixaban Peak and Trough Concentrations. American journal of cardiovascular drugs : drugs, devices, and other interventions, 2023, Volume: 23, Issue:1 Topics: Amiodarone; Cohort Studies; Diltiazem; Humans; Pyridones	2023