amiodarone and diclofenac

amiodarone has been researched along with diclofenac in 28 studies

Research

Studies (28)

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (3.57)	18.7374
1990's	1 (3.57)	18.2507
2000's	11 (39.29)	29.6817
2010's	14 (50.00)	24.3611
2020's	1 (3.57)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Dansette, PM; Fontana, E; Poli, SM	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Bellman, K; Knegtel, RM; Settimo, L	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ	1
Miao, GX; Wang, YD; Yan, ZW; Zhang, LY	1
Barlow, JW; Lim, CF; Raggatt, LE; Stockigt, JR; Topliss, DJ	1
Hamblin, PS; Kolliniatis, E; Lim, CF; Stockigt, JR; Topliss, DJ	1
Dansette, PM; Jaouen, M; Johnson, EF; Macherey, AC; Mansuy, D; Marques-Soares, C; Melet, A; Sari, MA; Schoch, GA	1
Ekman, S; Fransson-Steen, R; Hagbjörk, AL; Löfgren, S; Terelius, Y	1
McGinnity, DF; Riley, RJ; Trigg, S; Tucker, J	1
Cadirci, E; Dengiz, GO; Halici, M; Halici, Z; Odabasoglu, F; Suleyman, H	1
Heinzle, E; Niklas, J; Noor, F	1
Fey, SJ; Wrzesinski, K	1

Reviews

2 review(s) available for amiodarone and diclofenac

Article	Year
Cytochrome p450 enzymes mechanism based inhibitors: common sub-structures and reactivity. Current drug metabolism, 2005, Volume: 6, Issue:5 Topics: Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Isoenzymes; Structure-Activity Relationship; Terminology as Topic	2005
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016

Other Studies

26 other study(ies) available for amiodarone and diclofenac

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
FDA-approved drug labeling for the study of drug-induced liver injury. Drug discovery today, 2011, Volume: 16, Issue:15-16 Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14 Topics: Animals; Antimalarials; Female; Ferrous Compounds; Heterocyclic Compounds, 1-Ring; Malaria; Mice; Peroxides; Plasmodium berghei; Plasmodium falciparum; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship	2017
Synthesis, in vitro ADME profiling and in vivo pharmacological evaluation of novel glycogen phosphorylase inhibitors. Bioorganic & medicinal chemistry letters, 2020, 07-15, Volume: 30, Issue:14 Topics: Animals; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Glycogen Phosphorylase; Hep G2 Cells; Hepatocytes; Humans; Hypoglycemic Agents; Indoles; Mice; Molecular Structure; Rats; Structure-Activity Relationship	2020
Characterization of cytoplasmic T3 binding sites by adsorption to hydroxyapatite: effects of drug inhibitors of T3 and relationship to glutathione-S-transferases. Thyroid : official journal of the American Thyroid Association, 1992,Spring, Volume: 2, Issue:1 Topics: Amiodarone; Animals; Binding Sites; Binding, Competitive; Cytosol; Diclofenac; Dithiothreitol; Dose-Response Relationship, Drug; Durapatite; Furosemide; Glutathione Transferase; Hydrocortisone; Hydroxyapatites; In Vitro Techniques; Iopanoic Acid; Liver; Macaca fascicularis; Mefenamic Acid; Sulfobromophthalein; Taurocholic Acid; Triiodothyronine	1992
Furosemide, fenclofenac, diclofenac, mefenamic acid and meclofenamic acid inhibit specific T3 binding in isolated rat hepatic nuclei. Journal of endocrinological investigation, 1988, Volume: 11, Issue:5 Topics: Amiodarone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Nucleus; Diclofenac; Furosemide; In Vitro Techniques; Liver; Male; Meclofenamic Acid; Mefenamic Acid; Phenylacetates; Phenytoin; Rats; Rats, Inbred Strains; Receptors, Thyroid Hormone	1988
Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants. Biochemistry, 2004, Dec-14, Volume: 43, Issue:49 Topics: Amiodarone; Animals; Arginine; Aryl Hydrocarbon Hydroxylases; Asparagine; Catalysis; Chromans; Computer Simulation; Cytochrome P-450 CYP2C8; Diclofenac; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Indoles; Isoleucine; Models, Molecular; Mutagenesis, Site-Directed; Paclitaxel; Phenylalanine; Rabbits; Serine; Substrate Specificity; Sulfonamides; Thiazolidinediones; Tretinoin; Troglitazone	2004
Metabolism of human cytochrome P450 marker substrates in mouse: a strain and gender comparison. Xenobiotica; the fate of foreign compounds in biological systems, 2004, Volume: 34, Issue:9 Topics: Amiodarone; Animals; Aryl Hydrocarbon Hydroxylases; Blotting, Western; Chlorzoxazone; Coumarins; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2B6; Cytochrome P-450 Enzyme System; Dextromethorphan; Diclofenac; DNA, Complementary; Ethanolamines; Female; Humans; Kinetics; Lauric Acids; Male; Mephenytoin; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microsomes, Liver; Mixed Function Oxygenases; NADP; Nitrophenols; Oxidoreductases, N-Demethylating; Oxygen; Paclitaxel; Phenacetin; Rats; Sex Factors; Species Specificity; Substrate Specificity; Testosterone	2004
Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals, 2005, Volume: 33, Issue:11 Topics: Amiodarone; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Benzbromarone; Cytochrome P-450 CYP2C9; Diclofenac; Drug Interactions; Enzyme Inhibitors; Hepatocytes; Humans; In Vitro Techniques; Kinetics; Naproxen; Recombinant Proteins; Reproducibility of Results	2005
Amiodarone has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced paw edema. European journal of pharmacology, 2007, Jul-02, Volume: 566, Issue:1-3 Topics: Amiodarone; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carrageenan; Catalase; Diclofenac; Edema; Glutathione; Glutathione Reductase; Glutathione Transferase; Hindlimb; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Superoxide Dismutase	2007
Effects of drugs in subtoxic concentrations on the metabolic fluxes in human hepatoma cell line Hep G2. Toxicology and applied pharmacology, 2009, Nov-01, Volume: 240, Issue:3 Topics: Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Chromatography, High Pressure Liquid; Citric Acid Cycle; Diclofenac; Dimethyl Sulfoxide; Humans; Liver Neoplasms; Oxidative Phosphorylation; Oxygen; Pharmaceutical Preparations; Tacrine	2009
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line. Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 127, Issue:2 Topics: Acetaminophen; Adenosine Triphosphate; Amiodarone; Bioreactors; Diclofenac; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Lethal Dose 50; Metformin; Phenformin; Proteins; Reproducibility of Results; Risk Assessment; Spheroids, Cellular; Toxicity Tests; Valproic Acid	2012