amiodarone has been researched along with desethylamiodarone in 290 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 117 (40.34) | 18.7374 |
| 1990's | 82 (28.28) | 18.2507 |
| 2000's | 55 (18.97) | 29.6817 |
| 2010's | 28 (9.66) | 24.3611 |
| 2020's | 8 (2.76) | 2.80 |
| Authors | Studies |
|---|---|
| Bakker, O; van Beeren, HC; Wiersinga, WM | 4 |
| Katoh, M; Nakajima, M; Yamazaki, H; Yokoi, T | 1 |
| Gilmour, BP; Lewin, AH; Navarro, HA | 1 |
| Desaiah, D; Kodavanti, PR; Pentyala, SN; Yallapragada, PR | 1 |
| Asenjo, R; Biagini, L; Gaete, L; Ortiz, M; Saavedra, I | 1 |
| Hill, DA; Reasor, MJ | 2 |
| Caron, J; Lhermitte, M; Libersa, C; Pommery, J; Trivier, JM | 1 |
| de Vijlder, JJ; Plomp, TA; Vulsma, T | 1 |
| Levine, JH; Snowman, AM; Snyder, SH; Wagner, JA; Weisman, HF | 1 |
| Abdollah, H; Brennan, FJ; Brien, JF | 2 |
| Evans, SJ; Gang, E; Mandel, W; Myers, M; Nalos, P; Oseran, D; Peter, T; Simonson, J; Vaughn, C; Zaher, C | 1 |
| Desaiah, D; Vig, PJ | 1 |
| Antonini, JM; Reasor, MJ | 1 |
| Bonino, ML; Ramus, GV; Tonda, L; Veglio, F | 1 |
| Desaiah, D; Kodavanti, PR; Vig, PJ; Yallapragada, PR | 1 |
| Reasor, MJ | 1 |
| Abdollah, H; Brennan, FJ; Brien, JF; Jimmo, S | 1 |
| Funck-Brentano, C; Jacqz-Aigrain, E; Jaillon, P; Leenhardt, A; Poirier, JM; Roux, A | 1 |
| Doran, T; Lensmeyer, GL; Wiebe, DA | 1 |
| Berson, A; Fisch, C; Fromenty, B; Larrey, D; Letteron, P; Pessayre, D | 1 |
| Kodavanti, UP; Mehendale, HM | 1 |
| Bandyopadhyay, S; Klaunig, JE; Ruch, RJ; Somani, P | 1 |
| Guha, M; Kannan, R; Sarma, JS; Venkataraman, K | 2 |
| Clarkson, CE; Lippmann, ML; Wilson, BD | 1 |
| Bastien, O; Chassard, D; Estanove, S; George, M; Guiraud, M; Hercule, C; Lehot, JJ; Villard, J | 1 |
| Bandyopadhyay, S; Gross, SA; Klaunig, JE; Somani, P | 2 |
| Bandyopadhyay, S; Collins, J; Didio, LJ; Gross, SA; Snyder, VL; Somani, P | 1 |
| Hartong, R; Plomp, TA; Wiersinga, WM | 1 |
| Ogle, CL; Reasor, MJ | 1 |
| Kirk, RG; Lee, P; Reasor, MJ | 2 |
| Barr, ML; Giardina, EG; Schneider, M | 1 |
| Mostow, ND; Noon, D; Rakita, L; Vrobel, TR | 2 |
| Gear, K; Hoyer, GL; Karol, MD; Marcus, FI; Nolan, PE | 1 |
| Brien, JF; Daniels, JM; Leeder, RG; Massey, TE | 1 |
| Rabkin, SW | 1 |
| de Champlain, J; Lambert, C; Lamontagne, D; Nadeau, R; Yamaguchi, N | 1 |
| Duong, LT; Frawley, VL; Ou, CN; Rognerud, CL | 1 |
| Honegger, U; Küpfer, A; Müller, O; Pessayre, D; Pirovino, M; Tinel, M; Zysset, T | 1 |
| Carruthers, SG; Pollak, PT; Sharma, AD | 2 |
| Brien, JF; Daniels, JM; Leeder, RG; Massey, TE; Rafeiro, E | 1 |
| Lippmann, ML; Wilson, BD | 1 |
| Bandyopadhyay, S; Klaunig, JE; Somani, P | 1 |
| Bickel, MH; Moor, MJ; Wyss, PA | 2 |
| Schröder-van der Elst, JP; van der Heide, D | 1 |
| Bandyopadhyay, S; Somani, P | 1 |
| Davies, M; Nattel, S; Quantz, M | 1 |
| Nattel, S; Talajic, M | 1 |
| Holt, DW; Johnston, A; McKenna, WJ; Mulrow, JP; Robinson, K; Walker, S | 1 |
| Connell, MJ; Cumiskey, WR; Dillon, KM; Ezrin, AM; Silver, PJ; Volberg, WA | 1 |
| Arranz Peña, MI; Moro, C | 1 |
| Hearse, DJ; Riva, E | 1 |
| Beddows, SA; Johnstone, AP; McNerney, R; Nussey, SS; Page, SR; Taylor, AH; Whitley, GS | 1 |
| Cody, V; Luft, J | 1 |
| Caillard, C; Coulais, Y; Houin, G; Rochas, MA; Sqalli, A | 1 |
| Burgess, CD; Maling, TJ; Purdie, G; Siebers, RW; Taylor, C | 1 |
| Duff, HJ; Gillis, AM; Mitchell, LB; Wyse, DG | 1 |
| Allen, RA; Colvin, RA; Leek, D; Oibo, JA; Tyler, L | 1 |
| Brien, JF; Daniels, JM; Massey, TE | 1 |
| Kacew, S; Ogle, CL; Reasor, MJ; Walker, ER | 1 |
| Bernhard, R; Ferguson, RK; Fruncillo, RJ; Swanson, BN; Vlasses, PH | 1 |
| Bizzi, A; Cini, M; Latini, R; Marchi, S; Riva, E; Veneroni, E | 1 |
| Bódi, I; Rabloczky, G; Varró, A | 1 |
| Holt, DW; Johnston, A; McKenna, WJ; Robinson, K; Walker, S | 1 |
| Fraser, AG; McQueen, IN; Stephens, MR; Watt, AH | 1 |
| Chignell, CF; Li, AS | 1 |
| Adams, PC; Holt, DW; Morley, AR; Sloan, P | 1 |
| Bandyopadhyay, S; Dicarlo, LA; Gross, SA; Morady, F; Somani, P | 1 |
| Cheung, CK; Law, LK; Swaminathan, R | 1 |
| Holt, DW; Jackson, PR; McKenna, WJ; Tucker, GT | 1 |
| Harris, L; Holt, DW; McKenna, WJ; Mulrow, JP; Rowland, E | 1 |
| Adams, PC; Bennett, MK; Holt, DW | 1 |
| Hutchings, A; Morris, JM; Routledge, PA; Ward, MJ | 1 |
| Chen, CT; Ferguson, RI; Maling, TJ; Siebers, RW | 1 |
| Blayo, MC; Faurisson, F; Le Bras, J; Pussard, E; Scherrmann, JM; Verdier, F | 1 |
| Cavalli, A; Latini, R; Maggioni, AP; Tognoni, G; Volpi, A | 1 |
| Kamiya, K; Kannan, R; Kato, R; Singh, BN; Venkatesh, N; Yabek, S | 1 |
| Martin, WJ; Standing, JE | 1 |
| Giordano, JR; Hostetler, KY; Jellison, EJ | 1 |
| Connolly, SJ; Gupta, RN; Hoffert, D; Roberts, RS | 1 |
| Baker, JW; Dalton, MS; Kaiser, DL; Matthew, TL; Nolan, SP; Shipe, JR; Spotnitz, WD | 1 |
| Duff, HJ; Manyari, DE; Mitchell, LB; Sheldon, RS; Wyse, DG | 1 |
| Chlewicka, I; Paczkowski, D; Podleśny, J; Popławska, W; Walczak, F; Wójcik, E | 1 |
| Knowlton, PW; Liu, LL; Svensson, CK | 1 |
| Kannan, R; Miller, S; Perez, V; Singh, BN | 1 |
| Goldstein, RE; Latham, KR; Sellitti, DF | 1 |
| DiMarco, JP; Greenberg, ML; Kaiser, DL; Lerman, BB; Shipe, JR | 1 |
| Armstrong, PW; Brennan, FJ; Brien, JF; Ford, SE; Jimmo, S | 1 |
| Lesne, M; Pellegrin, PL | 1 |
| Garson, A; Kannan, R; McVey, P; Miller, S; Singh, BN; Yabek, SM | 1 |
| Falik, R; Flores, BT; Gibson, GA; Josephson, ME; Marchlinski, FE; Shaw, L | 1 |
| DeRoode, M; Nattel, S; Quantz, M; Talajic, M | 1 |
| Cardinal, R; Lambert, C; Lamontagne, D; Nadeau, R; Paradis, P; Rouleau, JL; Vermeulen, M | 1 |
| Ickrath, O; Krämer, B; Liebich, HM; Ress, K; Risler, T; Seipel, L | 1 |
| Bertani, T; Bizzi, A; Boeri, R; Cini, M; Latini, R; Marchi, S; Pesenti, A; Riva, E; Tavbani, E; Veneroni, E | 1 |
| Campbell, TJ; Pallandi, RT | 1 |
| Franklyn, JA; Gammage, MD; Logan, SD | 1 |
| Barbieri, E; D'Aranno, V; Fabbri, A; Latini, R; Trevi, GP; Zampieri, P; Zardini, P | 1 |
| Batsford, WP; Bookbinder, MJ; Kennedy, EE; McPherson, CA; Perlmutter, RA; Rosenfeld, LF | 1 |
| Carruthers, SG; Freeman, DJ; Pollak, PT | 1 |
| Bethge, KP; Bosse, K; Gonska, BD; Köbberling, J; Kreuzer, H; Quentin, CD; Wagner, H | 1 |
| Barbieri, E; Conti, F; d'Aranno, V; Latini, R; Trevi, GP; Zampieri, P; Zardini, P | 1 |
| Camus, P; Mehendale, HM | 1 |
| Hutchings, A; Routledge, PA; Stephens, MR; Watt, AH | 1 |
| Cardinal, R; Lambert, C; Nadeau, R; Vermeulen, M | 1 |
| Descatoire, V; Geneve, J; Larrey, D; Letteron, P; Pessayre, D; Tinel, M | 1 |
| Bambini, G; Braverman, LE; Fang, SL; Martino, E; Pinchera, A; Safran, M | 1 |
| Bucknall, CA; Curry, PV; Holt, DW; Keeton, BR; Sutherland, GR; Tynan, MJ | 1 |
| Lam, S | 1 |
| Bliss, M; Mayersohn, M; Nolan, P | 1 |
| Bersohn, M; Kato, R; Phair, R; Singh, BN; Somani, P; Venkatesh, N | 1 |
| Hutchings, A; Routledge, PA; Spragg, BP | 1 |
| DeRoode, MR; Nattel, S; Talajic, M | 1 |
| McManus, K; Simon, VA; Somani, P | 1 |
| Coumel, P; Escoubet, B; Jaillon, P; Leclercq, JF; Maison-Blanche, P; Poirier, JM; Slama, R | 1 |
| Adams, PC; Callaghan, J; Campbell, RW; Holt, DW; Morley, AR; Storey, GC | 1 |
| Baerman, JM; de Buitleir, M; DiCarlo, LA; Krol, RB; Morady, F | 1 |
| McCready, VR; Rao, RH; Spathis, GS | 1 |
| Al-Sarraf, L; Hershman, JM; Singh, BN; Venkatesh, N | 1 |
| Berger, Y; Commin, P; Echter, E; Escoubet, B; Jaillon, P; Menasché, P; Piwnica, A | 1 |
| Annesley, T; Baerman, JM; Crevey, BJ; DiCarlo, LA; Foley, MK; Morady, F; Nicklas, JM | 1 |
| Didio, LJ; Gross, SA; Simon, VA; Somani, P; Temesy-Armos, PN | 1 |
| Gardner, KM; Kook, KA; Muir, KT; Stern, C | 1 |
| Berger, Y; Desager, JP; Harvengt, C; Pacco, M; Pourbaix, S | 1 |
| Cheymol, G; Coumel, P; Escoubet, B; Jaillon, P; Lagier, G; Leclercq, JF; Maison-Blanche, P; Menasche, P; Piwnica, A; Poirier, JM | 1 |
| Holt, DW; Jeeva Raj, MV; Robson, DJ; Storey, GC | 1 |
| Ueda, CT; Weir, SJ | 1 |
| Maes, RA; Plomp, TA; Wiersinga, WM | 2 |
| Furlanello, F; Inama, G; Padrini, R; Piovan, D | 1 |
| Buss, DC; Routledge, PA; Stephens, MR; Watt, AH | 1 |
| Balmer, P; Bircher, J; Kohler, B; Schmid, B; Stäubli, M; Studer, H; Troendle, A | 1 |
| Farmer, PB; Flanagan, RJ; Holt, DW; Storey, GC | 1 |
| Greenspan, AM; Greenspon, AJ; Rotmensch, HH; Shoshani, D; Swanson, BN | 1 |
| Holt, DW; Rees, JR; Storey, GC; Wilkinson, PR | 1 |
| Adams, PC; Campbell, RW; Holt, DW; Storey, GC | 1 |
| Lüderitz, B; Nitsch, J | 1 |
| Belhassen, B; Greenspan, AM; Greenspon, AJ; Horowitz, LN; Rotmensch, HH; Shoshani, D; Spielman, SR; Swanson, BN; Vlasses, PH | 1 |
| Drachenberg, M; Ikeda, N; Kannan, R; Singh, BN; Wagner, R | 1 |
| Berdeaux, A; Edouard, A; Giroux, B; Giudicelli, JF; Labaille, T; Roche, A | 1 |
| Aquili, C; Ferrari, M; Fornaro, G; Fortina, A; Padrini, R; Piovan, D; Rossi, P; Tomassini, G | 1 |
| Heger, JJ; Prystowsky, EN; Solow, EB; Zipes, DP | 1 |
| Maes, RA; Plomp, TA; Robles de Medina, EO; van Lier, T; van Rossum, JM | 1 |
| Holt, DW; Jackson, PR; Storey, GC; Tucker, GT | 1 |
| Heger, JJ; Prystowsky, EN; Zipes, DP | 1 |
| Harris, L; Hind, CR; Holt, DW; Krikler, SJ; McKenna, WJ; Savage, C; Storey, GC | 1 |
| Blumer, JL; Mostow, ND; Myers, CM; Noon, DL; Rakita, L | 1 |
| Holt, DW; MacDonald, DM; Slater, DN; Storey, GC; Zachary, CB | 1 |
| Shipe, JR | 1 |
| Connolly, S; Gupta, RN | 1 |
| Connolly, SJ; Kates, RE; Latini, R | 1 |
| Armstrong, PW; Brien, JF; Jimmo, S | 1 |
| Engels, M; Maes, RA; Plomp, TA; Robles de Medina, EO | 1 |
| Holt, DW; Storey, GC | 1 |
| Curry, PV; Holt, DW; Holt, P; Storey, GC | 1 |
| Biagetti, MO; Quinteiro, RA | 1 |
| McCarthy, PT; O'Sullivan, JJ; Wren, C | 1 |
| Astier, H; Grazzini, E; Guipponi, M; Roussel, JP | 1 |
| Honegger, UE; Scuntaro, I; Wiesmann, UN | 1 |
| Chang, MS; Chen, CY; Chiang, HT; Hou, ZY; Lin, SL; Tu, MS; Woosley, RL | 1 |
| Hortiwakul, R; Jaruratanasirikul, S | 1 |
| Bersohn, MM; Hensley, CB; McDonough, AA; Sarma, JS; Singh, BN | 1 |
| Brien, JF; Evans, CD; Leeder, RG; Massey, TE | 1 |
| Caplin, JL; Nicholson, AA; Steventon, DM | 1 |
| Honegger, UE; Schaefer, MH; Scuntaro, I; Toplak, H; Wiesmann, UN; Zuehlke, RD | 1 |
| Belloc, C; Lhermitte, M; Libersa, C; Trivier, JM | 1 |
| Jandreski, MA; Vanderslice, WE | 1 |
| Blömer, H; Goedel-Meinen, L; Gries, E; Hofmann, M; Presch, A; Vuagnat, A | 1 |
| Bellen, JC; Penglis, S; Tsopelas, C | 1 |
| Blake, TL; Reasor, MJ | 1 |
| Aldern, KA; Beard, TL; Ebert, DC; Gardner, MF; Hostetler, KY; Kacew, S; McCloud, CM; Reasor, MJ | 1 |
| Berti, S; Biagini, A; Cazzuola, F; Clerico, A; Iervasi, G; Manfredi, C; Sabatino, L; Turchi, S | 1 |
| Pollak, PT | 2 |
| Mould, GP; Starkey, BJ | 1 |
| Chow, MS; Izard, M; Klamerus, KJ; Neefe, DL; O'Rangers, E; Ujhelyi, MR; Vadiei, K; Zimmerman, JJ | 1 |
| Aebi, Y; Thormann, W; Zhang, CX | 1 |
| Eddington, ND; Kharidia, J | 1 |
| Crijns, HJ; de Kam, PJ; Gosselink, AT; Lie, KI; Tieleman, RG; van den Berg, MP; van Gelder, IC; van Gilst, WH | 1 |
| Daoud, EG; Horwood, L; Man, KC; Morady, F; Strickberger, SA | 1 |
| Murthy, VV | 1 |
| Bory, M; Deharo, JC; Djiane, P; Durand, A; Le Tallec, L; Macaluso, G; Malaterre, H; Panagides, D | 1 |
| Kamiya, K; Kodama, I; Toyama, J | 1 |
| Gairola, CG; Reinhart, PG | 1 |
| Chen, BP; Chow, MS; Fan, C; Kluger, J; Zhou, L | 1 |
| Bertran, GC; Biagetti, MO; Quinteiro, RA; Valverde, ER | 1 |
| Bakker, O; Hudig, F; Meijssen, S; Wiersinga, WM | 1 |
| Blange, I; Drvota, V; Häggblad, J; Sylvén, C | 1 |
| Goebels, R; Keyser, A; Lehle, K; Merk, J; Preuner, JG; Rupprecht, L | 1 |
| Dart, AM; Du, XJ; Esler, MD; Haikerwal, D; Turner, A | 1 |
| Bakker, O; Chatterjee, VK; van Beeren, HC; Wiersinga, WM | 1 |
| Chen, BP; Chow, MS; Fan, C; Kluger, J; White, CM; Zhou, L | 1 |
| Dobrev, D; Grossmann, M; Himmel, HM; Kirch, W | 1 |
| Nakajima, M; Ohyama, K; Shimada, N; Suzuki, M; Yamazaki, H; Yokoi, T | 1 |
| Brique, SA; Caron, JF; Devos, P; Guédon-Moreau, LM; Humbert, L; Lhermitte, MA; Libersa, CC; Motte, KB; Vincent, A | 1 |
| Bargout, R; Dincer, E; Filippatos, G; Ibarra-Sunga, O; Jankov, A; Komodromos, T; Uhal, BD; Wang, R | 1 |
| Bouillon, T; Pollak, PT; Shafer, SL | 1 |
| Filippatos, GS; Uhal, BD | 1 |
| Chang, YJ; Kang, TK; Kim, DH; Kim, M; Min, HK; Myung, SW; Sohn, YT; Yim, YH; Yoo, EA | 1 |
| Bogazzi, F; D'Ascoli, F; Di Matola, T; Fenzi, G; Martino, E; Rossi, G; Vitale, M | 1 |
| Dobrev, D; Grossmann, M; Himmel, HM; Ravens, U | 1 |
| Altorfer, HR; Bigler, L; Binder, M; Follath, F; Ha, HR; Hesse, M; Kozlik, P; Stieger, B | 1 |
| Bartalena, L; Bogazzi, F; Brogioni, S; Burelli, A; Cosci, C; Fenzi, G; Martino, E; Raggi, F; Ultimieri, F; Vitale, M | 1 |
| Bigler, L; Follath, F; Ha, HR; Kozlik, P; Stieger, B | 2 |
| Agoston, M; Baláti, B; Delbruyère, M; Gautier, P; Hála, O; Iost, N; Németh, M; Nisato, D; Papp, JG; Pastor, G; Takács, J; Varró, A; Vereckei, A; Virág, L | 1 |
| Bolt, MW; Brien, JF; Card, JW; Massey, TE; Racz, WJ | 1 |
| Bolt, MW; Brien, JF; Massey, TE; Racz, WJ | 1 |
| Hagiwara, N; Kasanuki, H; Matsuda, N; Sato, K; Shiga, T; Shoda, M; Wakaumi, M | 1 |
| Kollroser, M; Schober, C | 1 |
| Fujii, E; Kasanuki, H; Naganuma, M; Nishikata, K; Shiga, T; Tsuchiya, T | 1 |
| Gambihler, S; Olgemöller, B; Schuhmann, E | 1 |
| Brien, JF; Card, JW; Massey, TE; Racz, WJ | 1 |
| Ando, M; Hanioka, N; Murayama, N; Ozawa, S; Saito, Y; Sawada, J; Soyama, A | 1 |
| Bakker, O; Jong, WM; Kaptein, E; Van Beeren, HC; Visser, TJ; Wiersinga, WM | 1 |
| Igoumenidis, NE; Kanoupakis, EM; Kochiadakis, GE; Manios, EG; Mavrakis, HE; Vardas, PE | 1 |
| Abe, K; Ayabe, Y; Hirakawa, K; Nishimura, M | 1 |
| Agoston, M; Blázovics, A; Fehér, E; Fehér, J; Hagymási, K; Orosz, Z; Orsi, F; Vereckei, A | 1 |
| Bognar, Z; Gallyas, F; Sumegi, B; Tapodi, A; Toth, A; Varbiro, G; Veres, B | 1 |
| Altorfer, HR; Baehler, M; Bigler, L; Kozlik, P; Puentener, C; Zerbe, O | 1 |
| Hanniman, EA; McCarthy, TC; Pollak, PT; Sinal, CJ | 1 |
| Carlson, GF; Eriksson, UG; Gillette, S; Hamer, JE; Kowey, PR; Sarich, TC; Schützer, KM; Teng, R | 1 |
| Abriel, H; Bellocq, C; Boixel, C; Chambellan, A; Charpentier, F; Chevalier, JC; Demolombe, S; El Harchi, A; Escande, D; Gavillet, B; Lande, G; Le Bouter, S; Le Quang, K; Léger, JJ; Marionneau, C; van Veen, T | 1 |
| Brocks, DR; El-Kadi, AO; Shayeganpour, A | 1 |
| Iida, H; Imuta, H; Jo, T; Kishida, S; Ma, J; Morita, T; Nagai, R; Nakajima, T; Oonuma, H; Takano, H | 1 |
| Bartalena, L; Benzi, L; Bogazzi, F; Cecchetti, P; Cosci, C; Dell'Unto, E; Martino, E; Raggi, F; Russo, D; Sardella, C; Tonacchera, M; Ultimieri, F; Vitti, P | 1 |
| Baert, K; Croubels, S; De Backer, P; De Clercq, D; Deprez, P; Maes, A; van Loon, G | 1 |
| Goto, T; Kamakura, S; Komamura, K; Kotake, T; Morishita, H; Takada, M | 1 |
| Kumar, V; Locuson, CW; Sham, YY; Tracy, TS | 1 |
| Fukumoto, K; Kamakura, S; Kato, R; Kitakaze, M; Kobayashi, T; Komamura, K; Tachibana, K; Tanaka, K; Ueno, K | 1 |
| Brocks, DR; Shayeganpour, A; Somayaji, V | 1 |
| Brocks, DR; Lee, SD; Shayeganpour, A; Wasan, KM | 1 |
| Goto, Y; Hirano, T; Iseki, K; Itagaki, S; Kimoto, E; Kobayashi, M; Matsuura, M; Seki, S; Tadano, K | 1 |
| Brocks, DR; Hamdy, DA; Shayeganpour, A | 2 |
| Brien, JF; Comeau, JL; Hill, BC; Ji, Y; Massey, TE; Nicolescu, AC; Racz, WJ; Takahashi, T | 1 |
| Hirano, T; Iseki, K; Itagaki, S; Kobayashi, M; Seki, S | 1 |
| Brocks, DR; El-Kadi, AO; Korashy, H; Patel, JP; Shayeganpour, A | 1 |
| García-Martínez, MD; Martínez-Lozano, C; Pérez-Ruiz, T | 1 |
| Han, TS; Vanderpump, MP; Williams, GR | 1 |
| Akhmedov, A; Bogdanova, A; Breitenstein, A; Camici, GG; Follath, F; Ha, HR; Lüscher, TF; Stämpfli, SF; Tanner, FC | 1 |
| Brocks, DR; Hamdy, DA | 1 |
| Hashimoto, H; Kume, T; Mori, K; Takatsu, H; Tsuda-Tsukimoto, M | 1 |
| Brocks, DR; Elsherbiny, ME | 1 |
| Götting, C; Kleesiek, K; Kuhn, J | 1 |
| Brocks, DR; El-Kadi, AO; Elsherbiny, ME | 2 |
| Bolderman, RW; Bruin, P; de Jong, MM; Dias, AA; Hermans, JJ; Maessen, JG; Rademakers, LM; van der Veen, FH | 1 |
| Hammoud, ZT; Kesler, KA; Rieger, KM; Tisdale, JE; Wall, DS; Wroblewski, HA; Young, JV | 1 |
| Hagiwara, N; Irie, S; Kasanuki, H; Shiga, T; Tanaka, T | 1 |
| Brecht, K; Krähenbühl, S; Lindinger, PW; Maseneni, S; Morand, R; Török, M; Zahno, A | 1 |
| Brien, JF; Massey, TE; Mulder, JE; Racz, WJ; Takahashi, T | 1 |
| Adams, MP; Agha, B; Cooper, WD; Cushing, DJ; Souney, PF | 1 |
| Baritussio, A; Bergonzini, V; Bigler, L; Calistri, A; Caretta, CM; Dal Zoppo, D; Del Vecchio, C; Faggin, E; Ha, HR; Nadai, M; Orlando, R; Palù, G; Pettenazzo, A; Piccoli, E; Salata, C | 1 |
| Chen, GR; Hong, LX; Lei, Z; Ying, YC | 1 |
| Sørensen, LK | 1 |
| Endo, S; Fukami, T; Nakajima, M; Toyoda, Y; Yokoi, T | 1 |
| Alves, G; Falcão, A; Queiroz, J; Rocha, M; Rodrigues, M | 1 |
| Brien, JF; Massey, TE; Mulder, JE; Roth, FC; Takahashi, T | 1 |
| Ai, T; Chang, PC; Chen, PS; Chen, Z; Lin, SF; Sohma, Y; Turker, I; Yu, CC | 1 |
| Bin Jardan, YA; Brocks, DR; Khurana, R; Wilkie, J | 1 |
| Chen, Y; Hop, CE; Mao, J | 1 |
| Casado, J; Cela, R; López-Sabater, MC; Montes, R; Rodríguez, I | 1 |
| Baczkó, I; Falkay, G; Leprán, I; Morvay, N; Papp, JG; Sztojkov-Ivanov, A; Varró, A | 1 |
| Cai, Y; Chen, F; Hu, ZY; Jia, WW; Lu, JT; Zhao, YS | 1 |
| Chai, CL; Chan, EC; Hong, Y; Karkhanis, A; Koh, SK; Kojodjojo, P; Lam, HY; Venkatesan, G; Zhou, L | 1 |
| Bryant, MS; Guo, L; Ning, B; Ren, Z; Wu, Q; Xuan, J | 1 |
| Fujimoto, M; Hayashi, T; Hosomi, K; Oita, A; Takada, M; Wada, K; Yamato, M | 2 |
| Antus, C; Bognar, R; Bognar, Z; Boronkai, A; Farkas, N; Fekete, K; Gallyas, F; Hocsak, E; Sumegi, B; Szanto, A; Tapodi, A | 1 |
| Bognar, R; Bognar, Z; Fekete, K; Sumegi, B; Szabo, A; Vass, RA | 1 |
| Antus, C; Bognar, R; Bognar, Z; Cseh, AM; Fekete, K; Gallyas, F; Ramadan, FHJ; Sumegi, B; Tapodi, A | 1 |
| Bognar, R; Bognar, Z; Gallyas, F; Kovacs, D; Ramadan, FHJ; Szabo, A; Takatsy, A | 1 |
| Pedro, L; Rudewicz, PJ | 1 |
| Cahill, JF; Kertesz, V | 1 |
| Aigner, Z; Árpádffy-Lovas, T; Baczkó, I; Demeter-Haludka, V; Déri, S; Földesi, I; Gazdag, P; Hornyik, T; Horváth, A; Husti, Z; Jost, N; Kohajda, Z; Koncz, I; Magyar, T; Nagy, N; Naveed, M; Ördög, B; Pászti, B; Patfalusi, M; Prorok, J; Szlovák, J; Sztojkov-Ivanov, A; Tálosi, L; Tiszlavicz, L; Topal, L; Tóth, N; Varga, R; Varró, A; Virág, L | 1 |
| Andreidesz, K; Bognar, R; Bognar, Z; Fekete, K; Gallyas, F; Hocsak, E; Kiss, GN; Ramadan, FHJ; Szabo, A; Szanto, A; Tapodi, A | 1 |
| Akai, N; Hanada, K; Hirai, T; Itoh, T; Iwamoto, T; Kasai, H; Takahashi, M; Uchida, S | 1 |
| Abdalla, S; Barbanti, C; Bonnet, D; Bouazza, N; Di Marzio, A; Foissac, F; Lehnert, A; Oualha, M; Renolleau, S; Treluyer, JM; Urien, S; Zheng, Y | 1 |
4 review(s) available for amiodarone and desethylamiodarone
| Article | Year |
|---|---|
Recent advances in understanding the pharmacology of amiodarone.
Topics: Amiodarone; Humans; Ion Channels; Thyroid Gland; Time Factors | 1988 |
A systematic review and critical comparison of internal standards for the routine liquid chromatographic assay of amiodarone and desethylamiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Bepridil; Chromatography, High Pressure Liquid; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Monitoring; Estrogen Antagonists; Tamoxifen; Trifluoperazine | 1996 |
Cellular electropharmacology of amiodarone.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Antithyroid Agents; Dogs; Heart; Humans; Ion Transport; Rats | 1997 |
Benzofuran derivatives and the thyroid.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Benzofurans; Dronedarone; Humans; Hypothyroidism; Receptors, Thyroid Hormone; Thyroid Diseases; Thyroid Gland; Thyrotoxicosis | 2009 |
16 trial(s) available for amiodarone and desethylamiodarone
| Article | Year |
|---|---|
[Amiodarone and its infusion velocity in recent-onset atrial fibrillation].
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Atrial Fibrillation; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Middle Aged; Time Factors | 1991 |
Relationship between preoperative amiodarone treatment and complications observed during anaesthesia for valvular cardiac surgery.
Topics: Adult; Aged; Amiodarone; Anesthesia, General; Aortic Valve; Arrhythmias, Cardiac; Depression, Chemical; Female; Heart Valve Prosthesis; Hemodynamics; Humans; Male; Middle Aged; Mitral Valve; Myocardial Contraction; Random Allocation | 1990 |
Amiodarone and N-desethylamiodarone concentrations in plasma, red blood cells, and myocardium after a single oral dose: relation to hemodynamic effects in surgical patients.
Topics: Administration, Oral; Adult; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Blood Pressure; Erythrocytes; Female; Heart Rate; Heart Valves; Hemodynamics; Humans; Male; Middle Aged; Myocardium; Postoperative Complications; Stroke Volume; Vascular Resistance | 1986 |
Multicenter controlled observation of a low-dose regimen of amiodarone for treatment of severe ventricular arrhythmias. Collaborative Group for Amiodarone Evaluation.
Topics: Adolescent; Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Child; Clinical Trials as Topic; Electrocardiography; Female; Heart Ventricles; Humans; Hyperthyroidism; Hypothyroidism; Male; Middle Aged; Prospective Studies; Systole | 1984 |
Acute treatment of recent-onset atrial fibrillation and flutter with a tailored dosing regimen of intravenous amiodarone. A randomized, digoxin-controlled study.
Topics: Aged; Aged, 80 and over; Amiodarone; Analysis of Variance; Atrial Fibrillation; Atrial Flutter; Digoxin; Electrocardiography; Female; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged | 1995 |
Relation between amiodarone and desethylamiodarone plasma concentrations and ventricular defibrillation energy requirements.
Topics: Aged; Amiodarone; Defibrillators, Implantable; Electric Countershock; Female; Humans; Male; Middle Aged; Prospective Studies | 1997 |
Clinical electrophysiologic effects of a single high oral dose of amiodarone.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Node; Bundle of His; Electrocardiography; Electrophysiology; Female; Heart Atria; Humans; Male; Middle Aged; Purkinje Fibers; Sinoatrial Node; Ventricular Function, Right | 1997 |
Dramatic inhibition of amiodarone metabolism induced by grapefruit juice.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Area Under Curve; Aryl Hydrocarbon Hydroxylases; Beverages; Biotransformation; Citrus; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Electrocardiography; Food-Drug Interactions; Half-Life; Humans; Male; Oxidoreductases, N-Demethylating | 2000 |
Role of desethylamiodarone in the anticoagulant effect of concurrent amiodarone and warfarin therapy.
Topics: Adult; Aged; Amiodarone; Anticoagulants; Drug Interactions; Drug Therapy, Combination; Female; Heart Diseases; Humans; International Normalized Ratio; Male; Middle Aged; Warfarin | 2001 |
Pharmacological cardioversion of recent onset atrial fibrillation with intravenous amiodarone in patients receiving long-term amiodarone therapy: is it reasonable?
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Biomarkers; Blood Pressure; Electric Countershock; Electrophysiologic Techniques, Cardiac; Female; Heart Atria; Heart Conduction System; Heart Rate; Humans; Infusions, Intravenous; Male; Middle Aged; Multivariate Analysis; Predictive Value of Tests; Stroke Volume; Time; Time Factors; Treatment Outcome | 2003 |
A pharmacokinetic study of the combined administration of amiodarone and ximelagatran, an oral direct thrombin inhibitor.
Topics: Adolescent; Adult; Amiodarone; Anti-Arrhythmia Agents; Anticoagulants; Area Under Curve; Azetidines; Benzylamines; Drug Interactions; Half-Life; Humans; Male; Middle Aged; Partial Thromboplastin Time; Regression Analysis; Single-Blind Method; Thrombin | 2004 |
Effect of amiodarone on the serum concentration/dose ratio of metoprolol in patients with cardiac arrhythmia.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Therapy, Combination; Female; Humans; Male; Metoprolol; Middle Aged | 2006 |
A randomized, controlled study of amiodarone for prevention of atrial fibrillation after transthoracic esophagectomy.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Chi-Square Distribution; Critical Care; Drug Administration Schedule; Esophagectomy; Female; Humans; Incidence; Indiana; Infusions, Intravenous; Kaplan-Meier Estimate; Length of Stay; Male; Middle Aged; Prospective Studies; Time Factors; Treatment Outcome | 2010 |
Pharmacokinetics of intravenous amiodarone and its electrocardiographic effects on healthy Japanese subjects.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Area Under Curve; Asian People; Biotransformation; Blood Pressure; Computer Simulation; Electrocardiography, Ambulatory; Half-Life; Heart Rate; Humans; Infusions, Intravenous; Japan; Male; Models, Biological; Young Adult | 2011 |
Comparative bioavailability of a premixed, ready-to-use formulation of intravenous amiodarone with traditional admixture in healthy subjects.
Topics: Administration, Intravenous; Adult; Amiodarone; Anti-Arrhythmia Agents; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Female; Humans; Male; Middle Aged; Single-Blind Method; Therapeutic Equivalency; Young Adult | 2012 |
Physiologically based pharmacokinetic modeling to predict drug-drug interactions involving inhibitory metabolite: a case study of amiodarone.
Topics: Administration, Oral; Adult; Amiodarone; Anti-Arrhythmia Agents; Biotransformation; Computer Simulation; Cytochrome P-450 CYP2C9 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Expert Systems; Female; Humans; Infusions, Intravenous; Liver; Male; Middle Aged; Models, Biological; Reproducibility of Results; Young Adult | 2015 |
270 other study(ies) available for amiodarone and desethylamiodarone
| Article | Year |
|---|---|
Structure-function relationship of the inhibition of the 3,5,3'-triiodothyronine binding to the alpha1- and beta1-thyroid hormone receptor by amiodarone analogs.
Topics: Amiodarone; Animals; Binding, Competitive; Chickens; Kinetics; Molecular Conformation; Molecular Structure; Rats; Receptors, Thyroid Hormone; Recombinant Fusion Proteins; Structure-Activity Relationship; Triiodothyronine | 1996 |
Inhibitory effects of CYP3A4 substrates and their metabolites on P-glycoprotein-mediated transport.
Topics: Amiodarone; Animals; Antibiotics, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Calcium Channel Blockers; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Daunorubicin; Digoxin; Enzyme Inhibitors; GABA Modulators; Gonadal Steroid Hormones; Humans; LLC-PK1 Cells; Midazolam; Mixed Function Oxygenases; Nifedipine; Phthalazines; Swine; Testosterone | 2001 |
Amiodarone and its putative metabolites fail to activate wild type hTAAR1.
Topics: Amiodarone; Animals; CHO Cells; Cricetinae; Cricetulus; Humans; Rats; Receptors, G-Protein-Coupled; Transfection | 2009 |
Amiodarone and desethylamiodarone increase intrasynaptosomal free calcium through receptor mediated channel.
Topics: Amiodarone; Animals; Binding Sites; Calcium; Calcium Channels; Dizocilpine Maleate; Male; Microsomes; Mitochondria; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Sodium Channels; Synaptosomes; Tetrodotoxin; Verapamil | 1992 |
[Determination of plasma concentration of amiodarone and desethylamiodarone with high pressure liquid chromatography. Preliminary experience].
Topics: Adult; Aged; Amiodarone; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Sensitivity and Specificity | 1992 |
Effects of amiodarone administration during lactation in Fischer-344 rats.
Topics: Amiodarone; Animals; Animals, Newborn; Body Weight; Female; Lactation; Liver; Lung; Milk; Rats; Rats, Inbred F344 | 1992 |
High-performance liquid chromatographic assay for amiodarone N-deethylation in microsomes of rat liver.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Female; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 1992 |
Use of amiodarone during pregnancy.
Topics: Amiodarone; Arrhythmias, Cardiac; Female; Fetal Blood; Humans; Hypothyroidism; Infant, Newborn; Lactation; Male; Maternal-Fetal Exchange; Milk, Human; Placenta; Pregnancy; Pregnancy Complications, Cardiovascular; Thyroid Hormones | 1992 |
Differential effects of amiodarone and desethylamiodarone on calcium antagonist receptors.
Topics: Amiodarone; Animals; Brain; Calcium Channel Blockers; Calcium Channels; Heart; In Vitro Techniques; Isradipine; Kinetics; Male; Muscles; Myocardium; Oxadiazoles; Rats; Rats, Inbred Strains; Receptors, Nicotinic | 1990 |
Antiarrhythmic effect of chronic oral amiodarone treatment in dogs with myocardial infarction and reproducibly inducible sustained ventricular arrhythmias.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Electric Stimulation; Electrocardiography; Male; Myocardial Infarction; Refractory Period, Electrophysiological | 1990 |
High dose oral amiodarone loading: electrophysiologic effects and clinical tolerance.
Topics: Administration, Oral; Amiodarone; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance; Electrophysiology; Follow-Up Studies; Humans; Middle Aged; Recurrence; Tachycardia; Time Factors | 1992 |
Modulation of protein kinase C activity by amiodarone and desethylamiodarone.
Topics: Amiodarone; Animals; Male; Protein Kinase C; Radioligand Assay; Rats; Rats, Inbred Strains; Solubility | 1991 |
Accumulation of amiodarone and desethylamiodarone by rat alveolar macrophages in cell culture.
Topics: Amiodarone; Animals; Cells, Cultured; Macrophages, Alveolar; Male; Rats; Rats, Inbred F344 | 1991 |
Modulation of calmodulin properties by amiodarone and its major metabolite desethylamiodarone.
Topics: Amiodarone; Animals; Calcium; Calmodulin; Chlorpromazine; Fluorescence; Phosphoric Diester Hydrolases; Rats; Tyrosine | 1991 |
Influence of a pre-existing phospholipidosis on the accumulation of amiodarone and desethylamiodarone in rat alveolar macrophages.
Topics: Amiodarone; Animals; Chlorphentermine; Lipidoses; Macrophages; Male; Phospholipids; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 1991 |
Relationship between myocardial amiodarone concentration and antiarrhythmic effect in dogs with myocardial infarction and electrically induced ventricular arrhythmias.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Dogs; Electric Stimulation; Heart Ventricles; Myocardial Infarction; Myocardium; Ventricular Fibrillation | 1991 |
Influence of amiodarone on genetically determined drug metabolism in humans.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Arrhythmias, Cardiac; Arylamine N-Acetyltransferase; Cytochrome P-450 Enzyme System; Dextromethorphan; Female; Humans; Isoniazid; Liver; Male; Mephenytoin; Middle Aged; Phenotype | 1991 |
Application of the Empore solid-phase extraction membrane to the isolation of drugs from blood. I. Amiodarone and desethylamiodarone.
Topics: Amiodarone; Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Humans; Membranes, Artificial; Spectrophotometry | 1991 |
Dual effect of amiodarone on mitochondrial respiration. Initial protonophoric uncoupling effect followed by inhibition of the respiratory chain at the levels of complex I and complex II.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amiodarone; Animals; Dinitrophenols; Drug Synergism; Fatty Acids; Glutamates; Glutamic Acid; Malates; Male; Membrane Potentials; Mice; Mitochondria, Liver; Oligomycins; Oxygen Consumption; Protons; Stimulation, Chemical; Succinates; Succinic Acid; Tetraphenylborate | 1990 |
Effects of amiodarone administration during pregnancy in Fischer 344 rats.
Topics: Amiodarone; Animals; Birth Weight; Female; Litter Size; Liver; Lung; Maternal-Fetal Exchange; Placenta; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred F344; Weight Gain | 1991 |
Amiodarone- and desethylamiodarone-induced pulmonary phospholipidosis, inhibition of phospholipases in vivo, and alteration of [14C]amiodarone uptake by perfused lung.
Topics: Amiodarone; Animals; Bronchoalveolar Lavage Fluid; Germ-Free Life; Male; Phospholipases A; Phospholipids; Pulmonary Alveoli; Rats; Rats, Inbred F344; Solubility; Type C Phospholipases | 1991 |
Evaluation of amiodarone free radical toxicity in rat hepatocytes.
Topics: Acetylcysteine; Amiodarone; Animals; Antioxidants; Butylated Hydroxytoluene; Catalase; Dose-Response Relationship, Drug; Evaluation Studies as Topic; Free Radicals; Kinetics; Liver; Male; Phenylenediamines; Rats; Rats, Inbred Strains; Superoxide Dismutase; Time Factors | 1991 |
Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats.
Topics: Amiodarone; Animals; Liver; Lung; Macrophages; Male; Phospholipases A; Phospholipids; Rats; Rats, Inbred Strains; Tissue Distribution | 1991 |
Amiodarone-induced pulmonary inflammation. Correlation with drug dose and lung levels of drug, metabolite, and phospholipid.
Topics: Amiodarone; Animals; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Lung; Male; Phospholipids; Pulmonary Fibrosis; Rats; Rats, Inbred Strains | 1991 |
Amiodarone- and desethylamiodarone-induced myelinoid inclusion bodies and toxicity in cultured rat hepatocytes.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Inclusion Bodies; L-Lactate Dehydrogenase; Lethal Dose 50; Liver; Male; Microscopy, Electron; Rats; Rats, Inbred Strains | 1990 |
Subcellular changes of rat myocardium after treatment with amiodarone or desethylamiodarone, studied with electron microscopy.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Heart; Inclusion Bodies; Male; Microscopy, Electron; Myocardium; Rats; Rats, Inbred Strains | 1990 |
Amiodarone reduces the effect of T3 on beta adrenergic receptor density in rat heart.
Topics: Administration, Oral; Amiodarone; Animals; Male; Myocardium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Thyroxine; Time Factors; Triiodothyronine | 1990 |
Response of alveolar macrophages to amiodarone and desethylamiodarone, in vitro.
Topics: Amiodarone; Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Inclusion Bodies; L-Lactate Dehydrogenase; Macrophages; Male; Microscopy, Electron; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 1990 |
Application of X-ray microanalysis to the study of drug uptake in cell culture.
Topics: Amiodarone; Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Electron Probe Microanalysis; Iodine; Macrophages; Male; Organelles; Pulmonary Alveoli; Rats; Rats, Inbred F344 | 1990 |
Myocardial amiodarone and desethylamiodarone concentrations in patients undergoing cardiac transplantation.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Coronary Disease; Heart Transplantation; Humans; Male; Middle Aged; Myocardium | 1990 |
Rapid control of refractory atrial tachyarrhythmias with high-dose oral amiodarone.
Topics: Administration, Oral; Amiodarone; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Drug Evaluation; Electrocardiography, Ambulatory; Female; Follow-Up Studies; Heart Atria; Humans; Male; Tablets; Tachycardia; Time Factors | 1990 |
Effect of phenytoin on the clinical pharmacokinetics of amiodarone.
Topics: Administration, Oral; Adult; Amiodarone; Drug Evaluation; Half-Life; Humans; Injections, Intravenous; Male; Metabolic Clearance Rate; Phenytoin | 1990 |
Repeated amiodarone exposure in the rat: toxicity and effects on hepatic and extrahepatic monooxygenase activities.
Topics: Amiodarone; Animals; Biotransformation; Body Weight; Drug Administration Schedule; Fibrosis; Injections, Intraperitoneal; Liver; Lung; Male; Oxygenases; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Effect of amiodarone and desethylamiodarone on choline uptake and phosphatidylcholine biosynthesis in cultured chick cardiac myocytes.
Topics: Amiodarone; Animals; Biological Transport, Active; Cells, Cultured; Chick Embryo; Choline; Heart; Kinetics; Myocardium; Phosphatidylcholines | 1990 |
Absence of prejunctional sympathetic effect of amiodarone in hearts of open-chest anesthetized dogs.
Topics: Amiodarone; Anesthesia; Animals; Blood Pressure; Dogs; Electric Stimulation; Female; Heart; Heart Rate; Male; Myocardium; Neuromuscular Junction; Norepinephrine; Proteins; Sinoatrial Node; Sympathetic Nervous System | 1990 |
Liquid-chromatographic determination of amiodarone and N-desethylamiodarone in serum.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Regression Analysis | 1990 |
Differences in hepatic drug accumulation and enzyme induction after chronic amiodarone feeding of two rat strains: role of the hydroxylator phenotype?
Topics: Amiodarone; Animals; Body Weight; Chromatography, Gas; Chromatography, High Pressure Liquid; Enzyme Induction; Female; Hydroxylation; Liver; Microscopy, Electron; Microsomes, Liver; Organ Size; Pharmaceutical Preparations; Phenotype; Phospholipids; Rats; Rats, Inbred Strains; Species Specificity | 1990 |
Relation of amiodarone hepatic and pulmonary toxicity to serum drug concentrations and superoxide dismutase activity.
Topics: Alanine Transaminase; Amiodarone; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Female; Humans; Liver Diseases; Lung Diseases; Male; Middle Aged; Pulmonary Diffusing Capacity; Superoxide Dismutase | 1990 |
In vitro hepatic, renal, and pulmonary N-dealkylation of amiodarone.
Topics: Amiodarone; Animals; Benzoflavones; beta-Naphthoflavone; Biotransformation; Dealkylation; Dexamethasone; In Vitro Techniques; Kidney; Liver; Lung; Male; Rats; Rats, Inbred Strains | 1990 |
Pulmonary accumulation of amiodarone and N-desethylamiodarone. Relationship to the development of pulmonary toxicity.
Topics: Amiodarone; Animals; Bronchoalveolar Lavage Fluid; Chromatography, High Pressure Liquid; Endothelium, Vascular; Fibroblasts; Germ-Free Life; Lung; Lung Diseases; Rats; Rats, Inbred F344; Rats, Inbred Strains; Time Factors | 1990 |
Cytotoxic interactions of cardioactive cationic amphiphilic compounds in primary rat hepatocytes in culture.
Topics: Amiodarone; Animals; Atenolol; Biomarkers; Cardiotonic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; L-Lactate Dehydrogenase; Liver; Male; Microscopy, Electron; Microscopy, Electron, Scanning; Procainamide; Propranolol; Rats; Rats, Inbred Strains; Sotalol; Verapamil | 1990 |
Single-dose kinetics of tissue distribution, excretion and metabolism of amiodarone in rats.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Half-Life; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1990 |
Thyroxine, 3,5,3'-triiodothyronine, and 3,3',5'-triiodothyronine concentrations in several tissues of the rat: effects of amiodarone and desethylamiodarone on thyroid hormone metabolism [corrected].
Topics: Adipose Tissue, Brown; Amiodarone; Animals; Brain; Heart; Liver; Male; Myocardium; Organ Specificity; Pituitary Gland; Prostate; Rats; Rats, Inbred Strains; Testis; Thyroid Gland; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse | 1990 |
A comparison of plasma, white blood cell, red blood cell, and tissue distribution of amiodarone and desethylamiodarone in anesthetized dogs.
Topics: Amiodarone; Animals; Dogs; Erythrocytes; Female; Kidney; Leukocytes; Liver; Lung; Male; Muscles; Myocardium; Tissue Distribution | 1987 |
The antiarrhythmic efficacy of amiodarone and desethylamiodarone, alone and in combination, in dogs with acute myocardial infarction.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Dogs; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Male; Myocardial Infarction; Tachycardia; Time Factors | 1988 |
Antiarrhythmic effects of desethylamiodarone in dogs with subacute myocardial infarction and inducible ventricular arrhythmias.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Dogs; Electric Stimulation; Infusions, Intravenous; Male; Myocardial Infarction; Refractory Period, Electrophysiological | 1989 |
The digoxin-amiodarone interaction.
Topics: Aged; Amiodarone; Atrial Fibrillation; Biological Availability; Digoxin; Drug Interactions; Female; Humans; Male; Middle Aged | 1989 |
Inhibition of calmodulin and protein kinase C by amiodarone and other class III antiarrhythmic agents.
Topics: Actomyosin; Amiodarone; Animals; Anti-Arrhythmia Agents; Bepridil; Calcium; Calmodulin; Guinea Pigs; Imidazoles; Kinetics; Male; Phosphodiesterase Inhibitors; Protein Kinase C; Quaternary Ammonium Compounds; Sotalol | 1989 |
Amiodarone determination by high-performance liquid chromatography.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Humans; Regression Analysis | 1989 |
Amiodarone and desethylamiodarone toxicity in isolated hepatocytes in culture.
Topics: Amiodarone; Animals; Cell Membrane; Cell Nucleus; Cell Survival; Cells, Cultured; Chromatin; Endoplasmic Reticulum; Inclusion Bodies; L-Lactate Dehydrogenase; Liver; Male; Microscopy, Electron; Mitochondrial Swelling; Rats; Rats, Inbred Strains | 1989 |
Anti-arrhythmic effects of amiodarone and desethylamiodarone on malignant ventricular arrhythmias arising as a consequence of ischaemia and reperfusion in the anaesthetised rat.
Topics: Amiodarone; Anesthesia, Intravenous; Animals; Arrhythmias, Cardiac; Coronary Disease; Heart Ventricles; Hemodynamics; Male; Myocardial Reperfusion Injury; Rats; Rats, Inbred Strains | 1989 |
Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes.
Topics: Amiodarone; Cells, Cultured; Fibroblasts; Humans; Thyroid Gland; Time Factors | 1989 |
Structure-activity relationships of antiarrhythmic agents: crystal structure of amiodarone hydrochloride and two derivatives, and their conformational comparison with thyroxine.
Topics: Amiodarone; Anti-Arrhythmia Agents; Benzofurans; Molecular Conformation; Stereoisomerism; Structure-Activity Relationship; Thyroxine | 1989 |
Tissue drug accumulation and ultrastructural changes during amiodarone administration in rats.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Macrophages; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1989 |
High performance liquid chromatographic method for routine monitoring of amiodarone and desethylamiodarone plasma levels.
Topics: Amiodarone; Chromatography, High Pressure Liquid | 1989 |
Individual variability of amiodarone distribution in plasma and erythrocytes: implications for therapeutic monitoring.
Topics: Adult; Aged; Amiodarone; Dose-Response Relationship, Drug; Electrocardiography; Erythrocytes; Female; Humans; Male; Middle Aged | 1989 |
Electropharmacology of amiodarone therapy initiation. Time courses of onset of electrophysiologic and antiarrhythmic effects.
Topics: Aged; Amiodarone; Electrophysiology; Female; Humans; Male; Middle Aged; Tachycardia, Supraventricular; Time Factors; Ventricular Fibrillation | 1989 |
Interaction of amiodarone and desethylamiodarone with the cardiac muscarinic receptor in vitro.
Topics: Amiodarone; Animals; Binding, Competitive; Carbachol; Dogs; Kinetics; Myocardium; Quinuclidinyl Benzilate; Receptors, Muscarinic; Sarcolemma | 1989 |
Pulmonary fibrosis induced in the hamster by amiodarone and desethylamiodarone.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Cricetinae; Disease Models, Animal; Histocytochemistry; Hydroxyproline; Lung; Male; Mesocricetus; Pulmonary Fibrosis; Tissue Distribution | 1989 |
Correlation of amiodarone dosage, heart rate, QT interval and corneal microdeposits with serum amiodarone and desethylamiodarone concentrations.
Topics: Amiodarone; Cornea; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Half-Life; Heart Rate; Humans; Male; Middle Aged; Prospective Studies; Time Factors | 1989 |
Amiodarone-induced phospholipidosis in rat alveolar macrophages.
Topics: Amiodarone; Animals; Dose-Response Relationship, Drug; Inclusion Bodies; Macrophages; Male; Phospholipids; Pulmonary Alveoli; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1988 |
Effect of phenobarbitone on the pharmacokinetics and tissue levels of amiodarone in the rat.
Topics: Amiodarone; Animals; Benzofurans; Kinetics; Male; Phenobarbital; Rats; Rats, Inbred Strains | 1985 |
Amiodarone and desethylamiodarone tissue uptake in rats chronically treated with amiodarone is non-linear with the dose.
Topics: Amiodarone; Animals; Body Weight; Eating; Kinetics; Lung; Male; Phospholipids; Rats; Rats, Inbred Strains; Tissue Distribution | 1987 |
Antiarrhythmic effect of desethylamiodarone in conscious rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Injections, Intraperitoneal; Male; Myocardium; Rats | 1987 |
Effects of amiodarone on the kinetics of antipyrine.
Topics: Adult; Aged; Amiodarone; Antipyrine; Drug Interactions; Female; Half-Life; Humans; Male; Middle Aged | 1989 |
Peripheral neuropathy during longterm high-dose amiodarone therapy.
Topics: Aged; Amiodarone; Benzofurans; Female; Humans; Male; Middle Aged; Peripheral Nervous System Diseases | 1985 |
Spectroscopic studies of cutaneous photosensitizing agents--IX. A spin trapping study of the photolysis of amiodarone and desethylamiodarone.
Topics: Amiodarone; Electron Spin Resonance Spectroscopy; Humans; Photolysis; Radiation-Sensitizing Agents; Skin; Ultraviolet Rays | 1987 |
Peripheral neutrophil inclusions in amiodarone treated patients.
Topics: Adult; Aged; Amiodarone; Female; Humans; Inclusion Bodies; Male; Middle Aged; Neutrophils | 1986 |
Amiodarone and multilamellar inclusion bodies.
Topics: Amiodarone; Humans; Inclusion Bodies; Leukocytes; Myocardium | 1987 |
Possible interference by amiodarone and desethylamiodarone in thyroxin assays.
Topics: Amiodarone; Cross Reactions; Humans; Immunoenzyme Techniques; Thyroxine | 1988 |
Amiodarone pharmacokinetics.
Topics: Amiodarone; Benzofurans; Biological Availability; Drug Interactions; Half-Life; Humans; Kinetics; Tissue Distribution | 1986 |
Amiodarone dose titration: a method to minimise side effects during long term therapy.
Topics: Amiodarone; Benzofurans; Cardiomyopathy, Hypertrophic; Humans; Long-Term Care; Photosensitivity Disorders; Sleep Wake Disorders | 1986 |
Hepatic effects of amiodarone.
Topics: Amiodarone; Benzofurans; Humans; Liver; Liver Function Tests; Radiography | 1986 |
Association of seminal desethylamiodarone concentration and epididymitis with amiodarone treatment.
Topics: Adult; Amiodarone; Arrhythmias, Cardiac; Epididymitis; Humans; Male; Semen | 1988 |
Effect of blood sample tubes on amiodarone and desethylamiodarone concentrations.
Topics: Amiodarone; Blood Specimen Collection; Humans | 1988 |
New procedure for the high-performance liquid chromatographic determination of amiodarone and desethylamiodarone with solid-phase extraction of rat plasma and tissue samples.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Injections, Intravenous; Male; Rats; Rats, Inbred Strains; Tissue Distribution | 1988 |
Disposition of monodesethylamodiaquine after a single oral dose of amodiaquine and three regimens for prophylaxis against Plasmodium falciparum malaria.
Topics: Adult; Amiodarone; Amodiaquine; Animals; Female; Half-Life; Humans; Malaria; Male; Middle Aged; Plasmodium falciparum | 1987 |
Amiodarone and desethylamiodarone: plasma concentrations, therapeutic effects and side effects.
Topics: Amiodarone; Humans | 1988 |
Electrophysiologic effects of desethylamiodarone, an active metabolite of amiodarone: comparison with amiodarone during chronic administration in rabbits.
Topics: Action Potentials; Amiodarone; Animals; Heart; Male; Myocardial Contraction; Rabbits; Sinoatrial Node; Thyroid Hormones | 1988 |
Amiodarone pulmonary toxicity: biochemical evidence for a cellular phospholipidosis in the bronchoalveolar lavage of human subjects.
Topics: Amiodarone; Bronchoalveolar Lavage Fluid; Humans; Lipidoses; Lung; Phospholipids | 1988 |
In vitro inhibition of lysosomal phospholipase A1 of rat lung by amiodarone and desethylamiodarone.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Lung; Lysosomes; Male; Phospholipases; Phospholipases A; Phospholipases A1; Rats; Rats, Inbred F344; Solubility | 1988 |
Concentration response relationships of amiodarone and desethylamiodarone.
Topics: Amiodarone; Arrhythmias, Cardiac; Dose-Response Relationship, Drug; Electrocardiography; Humans; Time Factors | 1988 |
The reversal of amiodarone-induced perioperative reduction in cardiac systolic reserve in dogs.
Topics: Amiodarone; Animals; Chromatography, Liquid; Depression, Chemical; Dogs; Electrocardiography; Hemodynamics; Myocardial Contraction; Systole | 1988 |
Right and left ventricular function during chronic amiodarone therapy.
Topics: Aged; Amiodarone; Electrocardiography; Electrophysiology; Exercise Test; Female; Humans; Male; Middle Aged; Myocardial Contraction; Prospective Studies; Stroke Volume; Tachycardia | 1988 |
[Practical aspects of studies on amiodarone and desethylamiodarone levels in the sera of chronically treated patients].
Topics: Adolescent; Adult; Aged; Amiodarone; Humans; Middle Aged; Tachycardia, Supraventricular; Time Factors; Ventricular Fibrillation | 1987 |
Effect of amiodarone and desethylamiodarone on the pharmacokinetics of antipyrine in the rat.
Topics: Administration, Oral; Amiodarone; Animals; Antipyrine; Dose-Response Relationship, Drug; Injections, Intravenous; Liver; Male; Metabolic Clearance Rate; Rats; Rats, Inbred Strains | 1987 |
Sensitive method for the measurement of amiodarone and desethylamiodarone in serum and tissue and its application to disposition studies.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Humans; Kinetics; Rabbits; Species Specificity; Tissue Distribution | 1987 |
Interaction of amiodarone and desethylamiodarone with solubilized nuclear thyroid hormone receptors.
Topics: Amiodarone; Animals; Binding, Competitive; Cattle; Chemical Phenomena; Chemistry; Drug Interactions; Humans; Liver; Lymphocytes; Myocardium; Rats; Receptors, Thyroid Hormone; Structure-Activity Relationship; Triiodothyronine | 1987 |
Relation between amiodarone and desethylamiodarone plasma concentrations and electrophysiologic effects, efficacy and toxicity.
Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Coronary Disease; Dose-Response Relationship, Drug; Electrocardiography; Electrophoresis; Female; Humans; Male; Middle Aged; Osmolar Concentration; Recurrence | 1987 |
Distribution of amiodarone and its metabolite, desethylamiodarone, in human tissues.
Topics: Adipose Tissue; Adolescent; Aged; Aged, 80 and over; Amiodarone; Brain; Female; Humans; Kidney; Liver; Lung; Male; Myocardium; Pancreas; Thyroid Gland; Tissue Distribution | 1987 |
Rapid high-performance liquid chromatographic method for the determination of amiodarone and desethylamiodarone in human plasma and serum.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents | 1987 |
Amiodarone efficacy in a young population: relationship to serum amiodarone and desethylamiodarone levels.
Topics: Adolescent; Adult; Amiodarone; Child; Child, Preschool; Heart Ventricles; Humans; Infant; Tachycardia; Triiodothyronine | 1987 |
Relationship of steady-state serum concentrations of amiodarone and desethylamiodarone to therapeutic efficacy and adverse effects.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Arrhythmias, Cardiac; Female; Humans; Male; Middle Aged; Risk; Time Factors | 1987 |
Frequency-dependent effects of amiodarone on atrioventricular nodal function and slow-channel action potentials: evidence for calcium channel-blocking activity.
Topics: Action Potentials; Amiodarone; Animals; Atrioventricular Node; Calcium Channel Blockers; Dogs; Female; Heart Conduction System; Male | 1987 |
Lack of relation between the ventricular refractory period prolongation by amiodarone and the thyroid state in rats.
Topics: Action Potentials; Amiodarone; Animals; Heart Rate; Male; Myocardium; Myosins; Rats; Rats, Inbred Strains; Thyroid Gland; Thyroidectomy; Thyroxine; Triiodothyronine; Ventricular Function | 1987 |
Determination of amiodarone and its metabolite N-desethylamiodarone in serum by high-performance liquid chromatography--comparison of different extraction procedures.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Female; Humans; Indicators and Reagents; Male | 1987 |
Amiodarone induced phospholipidosis. Biochemical, morphological and functional changes in the lungs of rats chronically treated with amiodarone.
Topics: Amiodarone; Animals; Body Weight; Eating; Lipidoses; Lung; Lung Compliance; Male; Phospholipids; Pulmonary Gas Exchange; Rats; Tissue Distribution | 1987 |
Resting, and rate-dependent depression of Vmax of guinea-pig ventricular action potentials by amiodarone and desethylamiodarone.
Topics: Action Potentials; Amiodarone; Animals; Female; Guinea Pigs; Heart; In Vitro Techniques; Male; Myocardium | 1987 |
Effects of amiodarone and thyroid dysfunction on myocardial calcium, serum calcium and thyroid hormones in the rat.
Topics: Amiodarone; Animals; Calcium; Hypothyroidism; In Vitro Techniques; Male; Muscle Proteins; Myocardium; Rats; Rats, Inbred Strains; Thyroid Diseases; Thyroid Hormones | 1987 |
Distribution of amiodarone and desethylamiodarone in a patient with acute myocardial infarction after intravenous administration.
Topics: Amiodarone; Female; Humans; Injections, Intravenous; Male; Middle Aged; Myocardial Infarction; Tissue Distribution | 1987 |
Dissociation of electrophysiologic and pharmacologic stability during an abbreviated oral loading regimen of amiodarone.
Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Chromatography, High Pressure Liquid; Drug Administration Schedule; Drug Evaluation; Electrophysiology; Female; Heart Ventricles; Humans; Male; Middle Aged; Ventricular Fibrillation | 1987 |
Rapid suppression of complex ventricular arrhythmias with high-dose oral amiodarone.
Topics: Administration, Oral; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Drug Administration Schedule; Electrocardiography; Follow-Up Studies; Heart Rate; Heart Ventricles; Hemodynamics; Humans; Kinetics | 1986 |
Simplified liquid-chromatographic assay of amiodarone and desethylamiodarone after solid-phase extraction.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Humans | 1986 |
[Amiodarone therapy--behavior of serum and fatty tissue concentrations].
Topics: Adipose Tissue; Adult; Aged; Amiodarone; Benzofurans; Biotransformation; Dose-Response Relationship, Drug; Electrocardiography; Female; Follow-Up Studies; Humans; Kinetics; Male; Middle Aged; Tachycardia | 1986 |
Amiodarone and desethylamiodarone distribution in the atrium and adipose tissue of patients undergoing short- and long-term treatment with amiodarone.
Topics: Adipose Tissue; Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Cardiac Surgical Procedures; Heart Atria; Humans; Kinetics; Middle Aged; Myocardium; Time Factors | 1986 |
Pulmonary sequestration of amiodarone and desethylamiodarone.
Topics: Amiodarone; Animals; Benzofurans; Chromatography, High Pressure Liquid; In Vitro Techniques; Lipidoses; Lung; Male; Perfusion; Phospholipids; Rabbits; Rats; Rats, Inbred F344; Rats, Inbred Strains | 1986 |
Plasma amiodarone concentrations during intravenous infusion.
Topics: Aged; Amiodarone; Benzofurans; Female; Heart Diseases; Humans; Infusions, Parenteral; Kinetics; Male; Middle Aged | 1986 |
Effect of the induction of amiodarone biotransformation on ventricular refractory periods in rats.
Topics: Action Potentials; Amiodarone; Animals; Benzofurans; Biotransformation; Heart Ventricles; Kinetics; Male; Myocardium; Phenobarbital; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Formation of an inactive cytochrome P-450Fe(II)-metabolite complex after administration of amiodarone in rats, mice and hamsters.
Topics: Amiodarone; Animals; Benzofurans; Carbon Monoxide; Cricetinae; Cytochrome P-450 Enzyme System; Dexamethasone; Dithionite; Dose-Response Relationship, Drug; Ferrous Compounds; Iron; Liver; Male; Mice; Organ Size; Oxygenases; Rats; Rats, Inbred Strains; Time Factors | 1986 |
Effects of amiodarone and desethylamiodarone on pituitary deiodinase activity and thyrotropin secretion in the rat.
Topics: Amiodarone; Animals; Benzofurans; Hypothyroidism; In Vitro Techniques; Iodide Peroxidase; Liver; Male; Pituitary Gland; Rats; Rats, Inbred Strains; Thyroid Hormones; Thyrotropin | 1986 |
Intravenous and oral amiodarone for arrhythmias in children.
Topics: Administration, Oral; Adolescent; Amiodarone; Arrhythmias, Cardiac; Atrial Flutter; Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Injections, Intravenous; Male; Tachycardia | 1986 |
High-performance liquid chromatography of amiodarone and desethylamiodarone in serum after microscale protein precipitation.
Topics: Amiodarone; Blood Proteins; Chromatography, High Pressure Liquid; Humans; Solvents | 1986 |
High-performance liquid chromatographic analysis of amiodarone and desethylamiodarone in serum.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Injections, Intravenous; Kinetics; Male | 1986 |
Electropharmacology of amiodarone: absence of relationship to serum, myocardial, and cardiac sarcolemmal membrane drug concentrations.
Topics: Amiodarone; Animals; Drug Administration Schedule; Heart Ventricles; Kinetics; Male; Myocardium; Rabbits; Sarcolemma | 1986 |
High-performance liquid chromatographic assay of amiodarone and desethylamiodarone in plasma.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Humans | 1986 |
Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metabolite.
Topics: Amiodarone; Animals; Atrioventricular Node; Blood Pressure; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Heart; Injections, Intravenous | 1987 |
Pharmacokinetics, antiarrhythmic effects, and tissue concentrations of amiodarone and desethylamiodarone in dogs with acute coronary artery occlusion.
Topics: Amiodarone; Animals; Arrhythmias, Cardiac; Benzofurans; Biotransformation; Chromatography, High Pressure Liquid; Dogs; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Conduction System; Hemodynamics; Male; Myocardial Infarction; Myocardium | 1985 |
[Anti-arrhythmic effect of amiodarone in the 24 hours following a single oral loading dose. Clinical and pharmacological study].
Topics: Administration, Oral; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Dose-Response Relationship, Drug; Female; Humans; Kinetics; Male | 1985 |
Amiodarone and its desethyl metabolite: tissue distribution and morphologic changes during long-term therapy.
Topics: Adolescent; Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Coronary Disease; Female; Humans; Liver; Long-Term Care; Lung; Male; Middle Aged; Skin | 1985 |
Acute and chronic effects of amiodarone on ventricular refractoriness, intraventricular conduction and ventricular tachycardia induction.
Topics: Administration, Oral; Aged; Amiodarone; Benzofurans; Cardiac Pacing, Artificial; Electric Stimulation; Electrophysiology; Female; Heart Conduction System; Heart Ventricles; Humans; Infusions, Parenteral; Male; Middle Aged; Tachycardia; Time Factors; Triiodothyronine | 1986 |
Iodine kinetic studies during amiodarone treatment.
Topics: Adult; Aged; Amiodarone; Benzofurans; Biological Availability; Female; Humans; Iodides; Iodine; Kinetics; Male; Mathematics; Metabolic Clearance Rate; Middle Aged; Thyroid Gland; Thyroid Hormones | 1986 |
Effects of desethylamiodarone on thyroid hormone metabolism in rats: comparison with the effects of amiodarone.
Topics: Amiodarone; Animals; Benzofurans; Chemical Phenomena; Chemistry; Male; Rats; Rats, Inbred F344; Thyroid Hormones; Thyroxine; Triiodothyronine; Triiodothyronine, Reverse | 1986 |
Interrelationships between serum levels of amiodarone, desethylamiodarone, reverse T3 and the QT interval during long-term amiodarone treatment.
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Electrocardiography; Female; Follow-Up Studies; Humans; Male; Middle Aged; Time Factors; Triiodothyronine, Reverse | 1986 |
Amiodarone-associated changes in human neutrophils.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Erythrocyte Count; Female; Half-Life; Humans; Leukocyte Count; Male; Microscopy, Electron; Neutrophils; Time Factors | 1986 |
Analysis of amiodarone and desethylamiodarone in serum and tears by reversed-phase high-performance liquid chromatography.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Tears; Trifluoperazine | 1986 |
Absolute bioavailability of amiodarone in normal subjects.
Topics: Administration, Oral; Adult; Amiodarone; Benzofurans; Biological Availability; Chromatography, High Pressure Liquid; Female; Humans; Injections, Intravenous; Male; Random Allocation; Tablets; Time Factors | 1985 |
Suppression of arrhythmias within hours after a single oral dose of amiodarone and relation to plasma and myocardial concentrations.
Topics: Administration, Oral; Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular Node; Benzofurans; Dose-Response Relationship, Drug; Electrocardiography; Female; Heart Atria; Humans; Male; Middle Aged; Myocardium; Tachycardia; Time Factors | 1985 |
Use of amiodarone during pregnancy.
Topics: Adult; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complications, Cardiovascular | 1985 |
Rapid liquid chromatographic assay for the determination of amiodarone and its N-deethyl metabolite in plasma, urine, and bile.
Topics: Amiodarone; Animals; Benzofurans; Bile; Chromatography, High Pressure Liquid; Drug Stability; Humans; Kinetics; Male; Rats; Rats, Inbred Strains | 1985 |
Tissue distribution of amiodarone and desethylamiodarone in rats after multiple intraperitoneal administration of various amiodarone dosages.
Topics: Amiodarone; Animals; Benzofurans; Chromatography, High Pressure Liquid; Injections, Intraperitoneal; Male; Rats; Rats, Inbred Strains; Time Factors; Tissue Distribution | 1985 |
Once per week oral administration of amiodarone in the prophylaxis of supraventricular paroxysmal tachycardia.
Topics: Amiodarone; Benzofurans; Female; Humans; Kinetics; Male; Tachycardia, Paroxysmal | 1985 |
Amiodarone reduces plasma warfarin clearance in man.
Topics: Aged; Amiodarone; Benzofurans; Blood Proteins; Female; Humans; Male; Middle Aged; Protein Binding; Warfarin | 1985 |
Pharmacokinetics of amiodarone, desethylamiodarone and other iodine-containing amiodarone metabolites.
Topics: Adolescent; Adult; Aged; Amiodarone; Angina Pectoris; Arrhythmias, Cardiac; Benzofurans; Female; Half-Life; Humans; Iodides; Iodine; Kinetics; Male; Middle Aged; Time Factors | 1985 |
Tissue distribution of amiodarone and desethylamiodarone in rats after repeated oral administration of various amiodarone dosages.
Topics: Administration, Oral; Amiodarone; Animals; Benzofurans; Biotransformation; Chromatography, High Pressure Liquid; Male; Rats; Tissue Distribution | 1985 |
Identification and measurement of desethylamiodarone in blood plasma specimens from amiodarone-treated patients.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Gas Chromatography-Mass Spectrometry; Humans | 1982 |
Amiodarone: individualizing dosage with serum concentrations.
Topics: Amiodarone; Animals; Benzofurans; Biological Availability; Cardiac Pacing, Artificial; Chromatography, High Pressure Liquid; Dogs; Half-Life; Humans; Kinetics; Rats; Tachycardia | 1983 |
Amiodarone: prolonged elimination following cessation of chronic therapy.
Topics: Amiodarone; Benzofurans; Half-Life; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Tachycardia | 1984 |
High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in small tissue samples after enzymatic digestion.
Topics: Adipose Tissue; Adult; Aged; Amiodarone; Animals; Benzofurans; Chromatography, High Pressure Liquid; Female; Humans; Lipase; Male; Methods; Middle Aged; Myocardium; Rabbits; Specimen Handling; Subtilisins; Tissue Distribution | 1983 |
[Control of anti-arrhythmia therapy with amiodarone. Value of the determination of blood levels].
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Erythrocytes; Humans; Long-Term Care; Middle Aged; Pulmonary Fibrosis | 1984 |
Steady-state serum amiodarone concentrations: relationships with antiarrhythmic efficacy and toxicity.
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Middle Aged; Recurrence; Tachycardia; Ventricular Fibrillation | 1984 |
Serum and myocardial kinetics of amiodarone and its deethyl metabolite after intravenous administration in rabbits.
Topics: Amiodarone; Animals; Benzofurans; Electrocardiography; Female; Injections, Intravenous; Kinetics; Myocardium; Rabbits | 1984 |
Tissue extraction of amiodarone and N-desethylamiodarone in man after a single oral dose.
Topics: Administration, Oral; Adult; Amiodarone; Benzofurans; Female; Humans; Liver; Male | 1984 |
[Pharmacological and clinical research on the interaction of digitalis and amiodarone in heart disease patients with varying degrees of cardiac insufficiency].
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Benzofurans; Digitalis Glycosides; Digoxin; Drug Interactions; Female; Heart Diseases; Humans; Male; Medigoxin; Middle Aged | 1984 |
Plasma and red blood cell concentrations of amiodarone during chronic therapy.
Topics: Amiodarone; Anorexia; Benzofurans; Erectile Dysfunction; Erythrocytes; Humans; Male; Nausea; Saliva; Tachycardia; Ventricular Fibrillation | 1984 |
Pharmacokinetics and body distribution of amiodarone in man.
Topics: Administration, Oral; Adult; Aged; Amiodarone; Benzofurans; Biotransformation; Female; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Tissue Distribution | 1984 |
Amiodarone pharmacokinetics.
Topics: Adipose Tissue; Adult; Aged; Amiodarone; Benzofurans; Female; Half-Life; Humans; Kinetics; Liver; Lung; Male; Metabolic Clearance Rate; Middle Aged | 1983 |
Relationships between amiodarone dosage, drug concentrations, and adverse side effects.
Topics: Amiodarone; Benzofurans; Dose-Response Relationship, Drug; Humans; Lung Diseases; Pigmentation Disorders; Time Factors | 1983 |
Renal elimination of amiodarone and its desethyl metabolite.
Topics: Amiodarone; Arrhythmias, Cardiac; Benzofurans; Female; Humans; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Peritoneal Dialysis; Renal Dialysis | 1983 |
Determination of amiodarone and its N-deethylated metabolite in serum by high-performance liquid chromatography.
Topics: Adult; Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Half-Life; Humans; Kinetics; Male; Middle Aged | 1983 |
The pathogenesis of amiodarone-induced pigmentation and photosensitivity.
Topics: Adult; Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Electron Probe Microanalysis; Humans; Male; Microscopy, Electron; Middle Aged; Photosensitivity Disorders; Skin; Skin Pigmentation | 1984 |
Liquid-chromatographic determination of amiodarone and its desethyl metabolite in plasma.
Topics: Amiodarone; Benzofurans; Chromatography, Liquid; Humans | 1984 |
Liquid-chromatographic determination of amiodarone and its N-desethyl metabolite in plasma.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Humans; Reference Standards | 1984 |
Myocardial disposition of amiodarone in the dog.
Topics: Administration, Oral; Amiodarone; Animals; Benzofurans; Dogs; Female; Injections, Intravenous; Male; Myocardium; Time Factors | 1983 |
Rapid high-performance liquid chromatographic analysis of amiodarone and N-desethyl-amiodarone in serum.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Humans | 1983 |
Simultaneous determination of amiodarone and its major metabolite desethylamiodarone in plasma, urine and tissues by high-performance liquid chromatography.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Humans; Kidney; Myocardium | 1983 |
High-performance liquid chromatographic measurement of amiodarone and desethylamiodarone in plasma or serum at the concentrations attained following a single 400-mg dose.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Humans; Microchemistry | 1982 |
High-performance liquid chromatographic measurement of amiodarone and its desethyl metabolite: methodology and preliminary observations.
Topics: Amiodarone; Benzofurans; Chromatography, High Pressure Liquid; Female; Humans; Middle Aged; Patient Compliance; Time Factors | 1982 |
Chronic versus acute effects of amiodarone on the Vmax-conduction velocity relationship and on the space constant in canine myocardium.
Topics: Action Potentials; Amiodarone; Animals; Chromatography, High Pressure Liquid; Computer Simulation; Coronary Circulation; Dogs; Female; Heart Conduction System; In Vitro Techniques; Male; Models, Biological; Myocardium; Regression Analysis | 1994 |
Differences in amiodarone, digoxin, flecainide and sotalol concentrations between antemortem serum and femoral postmortem blood.
Topics: Adolescent; Amiodarone; Anti-Arrhythmia Agents; Digoxin; Femoral Artery; Femoral Vein; Flecainide; Humans; Male; Postmortem Changes; Sotalol | 1995 |
Dihydropyridine-like effects of amiodarone and desethylamiodarone on thyrotropin secretion and intracellular calcium concentration in rat pituitary.
Topics: Amiodarone; Animals; Calcium; Calcium Channel Blockers; Cells, Cultured; Dihydropyridines; Drug Synergism; Male; Nifedipine; Peptide Fragments; Pituitary Gland; Protein Precursors; Rats; Rats, Wistar; Thyrotropin; Thyrotropin-Releasing Hormone; Triiodothyronine | 1995 |
Desethylamiodarone is a competitive inhibitor of the binding of thyroid hormone to the thyroid hormone alpha 1-receptor protein.
Topics: Amino Acid Sequence; Amiodarone; Animals; Binding Sites; Binding, Competitive; Chickens; Escherichia coli; Iodine Radioisotopes; Kinetics; Molecular Sequence Data; Receptors, Thyroid Hormone; Recombinant Proteins; Triiodothyronine | 1995 |
Vitamin E reduces accumulation of amiodarone and desethylamiodarone and inhibits phospholipidosis in cultured human cells.
Topics: Amiodarone; Cells, Cultured; Humans; Hydrolysis; Phospholipids; Vitamin E | 1995 |
The inhibitory effect of amiodarone and desethylamiodarone on dextromethorphan O-demethylation in human and rat liver microsomes.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Cytochrome P-450 Enzyme System; Dealkylation; Depression, Chemical; Dextromethorphan; Humans; In Vitro Techniques; Kinetics; Microsomes, Liver; Mixed Function Oxygenases; Rats; Rats, Wistar | 1994 |
Amiodarone decreases Na,K-ATPase alpha 2 and beta 2 expression specifically in cardiac ventricle.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Gene Expression; Heart Ventricles; Hypothyroidism; In Vitro Techniques; Isomerism; Male; Muscles; Myocardium; Organ Specificity; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Thyroxine; Triiodothyronine | 1994 |
Resistance of the hamster to amiodarone-induced pulmonary toxicity following repeated intraperitoneal administration.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Cricetinae; Disease Models, Animal; Hydroxyproline; Injections, Intraperitoneal; Liver; Lung; Male; Mesocricetus; Organ Size; Pulmonary Fibrosis; Tissue Distribution | 1994 |
Desethylamiodarone is a noncompetitive inhibitor of the binding of thyroid hormone to the thyroid hormone beta 1-receptor protein.
Topics: Amiodarone; Animals; Rats; Receptors, Thyroid Hormone; Solubility; Triiodothyronine | 1994 |
Measurement of tissue-bound amiodarone and its metabolites by computed tomography.
Topics: Aged; Amiodarone; Arrhythmias, Cardiac; Female; Humans; Iodine; Liver; Male; Middle Aged; Models, Structural; Tomography, X-Ray Computed | 1994 |
Cellular accumulation of amiodarone and desethylamiodarone in cultured human cells. Consequences of drug accumulation on cellular lipid metabolism and plasma membrane properties of chronically exposed cells.
Topics: Amiodarone; Cell Membrane; Cells, Cultured; Diphenylhexatriene; Humans; Lipid Metabolism; Macrophages; Membrane Fluidity; Phospholipids; Proteins; Receptors, Adrenergic, beta | 1993 |
X-ray microanalysis of cultured alveolar macrophages with phospholipidosis.
Topics: Amiodarone; Animals; Cell Nucleus; Cells, Cultured; Chlorphentermine; Electron Probe Microanalysis; Freeze Drying; Frozen Sections; Inclusion Bodies; Lipidoses; Macrophages, Alveolar; Male; Phospholipids; Potassium; Rats; Rats, Inbred F344; Sodium | 1993 |
Amiodarone N-deethylation in human liver microsomes: involvement of cytochrome P450 3A enzymes (first report).
Topics: Amiodarone; Aryl Hydrocarbon Hydroxylases; Biotransformation; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dealkylation; Humans; Isoenzymes; Kinetics; Microsomes, Liver; Oxidoreductases, N-Demethylating; Oxygenases | 1993 |
Clinical measurement of serum amiodarone and desethylamiodarone by using solid-phase extraction followed by HPLC with a high-carbon reversed-phase column.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Humans; Hydrogen-Ion Concentration; Triflupromazine | 1993 |
Stability of amiodarone in serum samples under various storage conditions.
Topics: Adult; Aged; Amiodarone; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Regression Analysis; Specimen Handling | 1993 |
Radiolabeling and biodistribution of amiodarone and desethylamiodarone.
Topics: Amiodarone; Animals; Copper; Female; Iodine Radioisotopes; Isotope Labeling; Mice; Mice, Inbred BALB C; Tissue Distribution | 1995 |
Metabolism of amiodarone following intratracheal instillation in hamsters.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cricetinae; Disease Models, Animal; Intubation, Intratracheal; Kinetics; Liver; Lung; Male; Mesocricetus; Microsomes; Pulmonary Fibrosis; Umbelliferones | 1995 |
Comparative evaluation of amiodarone-induced phospholipidosis and drug accumulation in Fischer-344 and Sprague-Dawley rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Kidney; Lipidoses; Liver; Macrophages, Alveolar; Male; Phospholipases A; Phospholipids; Rats; Rats, Inbred F344; Rats, Sprague-Dawley | 1996 |
Measurement of serum amiodarone and desethylamiodarone by HPLC: its usefulness in the follow-up of arrhythmic patients treated with amiodarone.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Chromatography, High Pressure Liquid; Female; Follow-Up Studies; Humans; Male; Middle Aged | 1995 |
An external quality assessment scheme for amiodarone and desethylamiodarone: initial results.
Topics: Amiodarone; Humans; Monitoring, Physiologic; Quality Assurance, Health Care; Reference Values; Surveys and Questionnaires | 1996 |
Disposition of intravenous amiodarone in subjects with normal and impaired renal function.
Topics: Adult; Aged; Amiodarone; Anti-Arrhythmia Agents; Female; Glomerular Filtration Rate; Humans; Infusions, Intravenous; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Reference Values; Renal Dialysis | 1996 |
Microassay of amiodarone and desethylamiodarone in serum by capillary electrophoresis with head-column field-amplified sample stacking.
Topics: Amiodarone; Caffeine; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Microchemistry; Reproducibility of Results; Theophylline | 1996 |
Effects of desethylamiodarone on the electrocardiogram in conscious freely moving animals: pharmacokinetic and pharmacodynamic modeling using computer-assisted radio telemetry.
Topics: Amiodarone; Animals; Computers; Electrocardiography; Heart Rate; Male; Models, Biological; Movement; Radio Waves; Rats; Rats, Sprague-Dawley; Telemetry | 1996 |
Efficacy, safety, and determinants of conversion of atrial fibrillation and flutter with oral amiodarone.
Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Atrial Fibrillation; Atrial Flutter; Echocardiography; Electric Countershock; Female; Humans; Male; Middle Aged; Multivariate Analysis; Prospective Studies | 1997 |
Unusual interference from primary collection tube in a high-performance liquid chromatography assay of amiodarone.
Topics: Amiodarone; Anti-Arrhythmia Agents; Blood Chemical Analysis; Blood Specimen Collection; Chromatography, High Pressure Liquid; Humans | 1997 |
Amiodarone-induced pulmonary toxicity in Fischer rats: release of tumor necrosis factor alpha and transforming growth factor beta by pulmonary alveolar macrophages.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Bronchoalveolar Lavage Fluid; Cell Count; Cells, Cultured; Enzyme-Linked Immunosorbent Assay; Female; Macrophages, Alveolar; Pulmonary Alveoli; Rats; Rats, Inbred F344; Trachea; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 1997 |
Effects of amiodarone and its active metabolite desethylamiodarone on the ventricular defibrillation threshold.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Electrocardiography; Heart Conduction System; Hemodynamics; Swine | 1998 |
Effects of amiodarone and desethylamiodarone on the inward rectifying potassium current (IK1) in rabbit ventricular myocytes.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Female; Heart Ventricles; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rabbits; Ventricular Function | 1998 |
Effects of triiodothyronine and amiodarone on the promoter of the human LDL receptor gene.
Topics: Amiodarone; Anti-Arrhythmia Agents; Carcinoma, Hepatocellular; Gene Expression; Humans; Liver Neoplasms; Promoter Regions, Genetic; Receptors, LDL; Receptors, Thyroid Hormone; Transfection; Triiodothyronine; Tumor Cells, Cultured | 1998 |
Desethylamiodarone prolongation of cardiac repolarization is dependent on gene expression: a novel antiarrhythmic mechanism.
Topics: Action Potentials; Amiodarone; Animals; Blotting, Western; Cycloheximide; Dactinomycin; Female; Gene Expression; Guinea Pigs; Heart; Homeostasis; Male; Protein Synthesis Inhibitors; Triiodothyronine | 1998 |
Development of severe adverse effects after discontinuing amiodarone therapy in human heart transplant recipients.
Topics: Amiodarone; Anti-Arrhythmia Agents; Bilirubin; Cyclosporine; Drug Interactions; Half-Life; Heart Transplantation; Humans; Immunosuppressive Agents; Neutrophils | 1998 |
Presynaptic antisympathetic action of amiodarone and its metabolite desethylamiodarone.
Topics: Amiodarone; Anesthesia; Animals; Brain; Drug Interactions; Heart; In Vitro Techniques; Male; Methoxyhydroxyphenylglycol; Norepinephrine; Perfusion; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Reserpine; Sympatholytics; Synaptosomes | 1999 |
Effect of mutations in the beta1-thyroid hormone receptor on the inhibition of T3 binding by desethylamiodarone.
Topics: Amino Acid Sequence; Amiodarone; Binding, Competitive; Dimerization; Humans; Molecular Sequence Data; Mutation; Protein Binding; Receptors, Thyroid Hormone; Sequence Homology, Amino Acid; Static Electricity; Triiodothyronine | 1999 |
A comparison of the antifibrillatory effects of desethylamiodarone to amiodarone in a swine model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Injections, Intravenous; Swine; Ventricular Fibrillation | 1999 |
Local venous response to N-desethylamiodarone in humans.
Topics: Adult; Amiodarone; Animals; Aorta; Blood Pressure; Calcium; Cattle; Dose-Response Relationship, Drug; Endothelium, Vascular; Hand; Heart Rate; Humans; Infusions, Intravenous; Male; Reference Values; Time Factors; Vasodilation; Vasodilator Agents; Veins | 2000 |
Inhibitory effects of amiodarone and its N-deethylated metabolite on human cytochrome P450 activities: prediction of in vivo drug interactions.
Topics: Amiodarone; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Enzyme Inhibitors; Humans; Tumor Cells, Cultured | 2000 |
Amiodarone induces apoptosis of human and rat alveolar epithelial cells in vitro.
Topics: Adenocarcinoma; Amino Acid Chloromethyl Ketones; Amiodarone; Angiotensin-Converting Enzyme Inhibitors; Animals; Apoptosis; Captopril; Cysteine Proteinase Inhibitors; Cytotoxins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Humans; In Vitro Techniques; Lung Neoplasms; Male; Pulmonary Alveoli; Rats; Rats, Wistar; Renin-Angiotensin System; Tumor Cells, Cultured | 2000 |
Population pharmacokinetics of long-term oral amiodarone therapy.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Chromatography, Liquid; Drug Administration Schedule; Female; Follow-Up Studies; Half-Life; Humans; Male; Middle Aged; Nonlinear Dynamics; Population Surveillance; Prospective Studies; Time Factors | 2000 |
Desethylamiodarone interferes with the binding of co-activator GRIP-1 to the beta 1-thyroid hormone receptor.
Topics: Amiodarone; Dose-Response Relationship, Drug; Humans; Nuclear Receptor Coactivator 2; Protein Binding; Receptors, Thyroid Hormone; Transcription Factors; Triiodothyronine | 2000 |
Effects of amiodarone on heart cells.
Topics: Amiodarone; Apoptosis; Epithelial Cells; Heart; Humans; Leukocytes, Mononuclear; Myocardium; Oxidative Stress; Pulmonary Alveoli; Tumor Necrosis Factor-alpha | 2000 |
Characterization of amiodarone metabolites and impurities using liquid chromatography/atmospheric pressure chemical ionization mass spectrometry.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Atmospheric Pressure; Biotransformation; Chromatography, High Pressure Liquid; Diethylamines; Glucosephosphate Dehydrogenase; Mass Spectrometry; Microsomes, Liver; Molecular Structure; Rats | 2000 |
Amiodarone induces cytochrome c release and apoptosis through an iodine-independent mechanism.
Topics: Amiodarone; Annexin A5; Anti-Arrhythmia Agents; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Cell Line; Cell Survival; Cycloheximide; Cytochrome c Group; Cytosol; HeLa Cells; Humans; Iodide Peroxidase; Kinetics; Mitochondria; Propylthiouracil; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Thyroid Gland; Tumor Suppressor Protein p53 | 2000 |
N-desethylamiodarone modulates intracellular calcium concentration in endothelial cells.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Aorta; Calcium; Calcium-Transporting ATPases; Cattle; Cell Division; Cells, Cultured; Cyclosporine; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Space; Homeostasis; Kinetics; Mitochondria; Thapsigargin; Vasodilator Agents | 2000 |
Metabolism of amiodarone (part I): identification of a new hydroxylated metabolite of amiodarone.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Biotransformation; Chromatography, High Pressure Liquid; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Microsomes, Liver; NADP; Rabbits; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Tissue Distribution | 2001 |
Desethylamiodarone antagonizes the effect of thyroid hormone at the molecular level.
Topics: 3T3 Cells; Amiodarone; Animals; Anti-Arrhythmia Agents; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Genes, Reporter; Mice; Rats; Receptors, Thyrotropin; Response Elements; Thyroxine; Transfection; Triiodothyronine | 2001 |
Metabolism of amiodarone. II. High-performance liquid chromatographic assay for mono-N-desethylamiodarone hydroxylation in liver microsomes.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Biotransformation; Chromatography, High Pressure Liquid; Humans; Hydroxylation; Microsomes, Liver; Rabbits; Rats; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 2001 |
Electrophysiological effects of dronedarone (SR 33589), a noniodinated amiodarone derivative in the canine heart: comparison with amiodarone.
Topics: Action Potentials; Amiodarone; Animals; Dogs; Dronedarone; Electric Stimulation; Electrocardiography; Electrophysiology; Female; Heart Ventricles; In Vitro Techniques; Male; Papillary Muscles; Purkinje Fibers; Vasodilator Agents; Ventricular Function | 2001 |
Metabolism of amiodarone (Part III): identification of rabbit cytochrome P450 isoforms involved in the hydroxylation of mono-N-desethylamiodarone.
Topics: Amiodarone; Animals; Anti-Anxiety Agents; Anti-Arrhythmia Agents; Aryl Hydrocarbon Hydroxylases; Benzoflavones; Chromatography, High Pressure Liquid; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ketoconazole; Kinetics; Microsomes, Liver; Midazolam; Models, Chemical; Oxidoreductases, N-Demethylating; Protein Isoforms; Quinidine; Rabbits; Rifampin; Time Factors | 2001 |
Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity.
Topics: Adenosine Triphosphate; Amiodarone; Animals; Cell Separation; Cell Survival; Cricetinae; Enzyme Inhibitors; Lung; Lung Diseases; Macrophages, Alveolar; Male; Membrane Potentials; Mesocricetus; Mitochondria; Oxygen Consumption; Permeability; Polarography | 2001 |
Effects of vitamin E on cytotoxicity of amiodarone and N-desethylamiodarone in isolated hamster lung cells.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antioxidants; Bronchi; Bronchoalveolar Lavage Fluid; Carbon Tetrachloride; Cell Separation; Cell Survival; Cells, Cultured; Cricetinae; Epithelial Cells; Free Radical Scavengers; Lipid Peroxidation; Lung; Macrophages, Alveolar; Male; Mesocricetus; Vitamin E | 2001 |
Amiodarone-Induced thyroid dysfunction and ventricular tachyarrhythmias during long-term therapy in Japan.
Topics: Adult; Aged; Amiodarone; Arrhythmias, Cardiac; Drug Evaluation; Female; Follow-Up Studies; Humans; Hyperthyroidism; Hypothyroidism; Japan; Male; Middle Aged; Recurrence; Tachycardia, Ventricular; Thyroid Diseases; Ventricular Premature Complexes | 2001 |
Altered metabolite concentrations with amiodarone generic substitution cannot be observed without monitoring.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Animals; Anti-Arrhythmia Agents; Drug Monitoring; Drugs, Generic; Female; Humans; Male; Middle Aged; Therapeutic Equivalency; Time Factors | 2001 |
Determination of amiodarone and desethylamiodarone in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry with an ion trap detector.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Humans; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2002 |
Amiodarone and desethylamiodarone bind to barrier gels in serum separator blood collection tubes.
Topics: Amiodarone; Anti-Arrhythmia Agents; Blood Specimen Collection; Drug Monitoring; Gels; Humans; Reproducibility of Results | 2002 |
Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-beta1 gene expression but not prevention of mitochondrial dysfunction.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antioxidants; Cricetinae; Diet; DNA Probes; Gene Expression; Hydroxyproline; In Situ Hybridization; Lung; Male; Membrane Potentials; Mesocricetus; Mitochondria; Oxygen Consumption; Polarography; Pulmonary Fibrosis; RNA, Messenger; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vitamin E | 2003 |
Amiodarone N-deethylation by CYP2C8 and its variants, CYP2C8*3 and CYP2C8 P404A.
Topics: Amiodarone; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C8; Metabolic Clearance Rate; Microsomes, Liver; Paclitaxel; Structure-Activity Relationship; Transfection | 2002 |
Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Dronedarone; Enzyme Activation; Heart Rate; In Vitro Techniques; Iodide Peroxidase; Liver; Male; Rats; Rats, Wistar; Thyroid Hormone Receptors alpha; Triiodothyronine | 2003 |
[Analysis of increased hepatic density during chronic amiodarone therapy].
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Female; Humans; Liver; Male; Middle Aged; Pulmonary Fibrosis; Tomography, X-Ray Computed | 2003 |
Silymarin and vitamin E reduce amiodarone-induced lysosomal phospholipidosis in rats.
Topics: Amiodarone; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Hepatocytes; Liver Diseases; Lysosomes; Male; Microscopy, Electron; Phospholipids; Random Allocation; Rats; Rats, Inbred F344; Silymarin; Thiobarbituric Acid Reactive Substances; Vitamin E | 2003 |
Protective effect of amiodarone but not N-desethylamiodarone on postischemic hearts through the inhibition of mitochondrial permeability transition.
Topics: Amiodarone; Animals; Apoptosis Inducing Factor; Biological Transport; Disease Models, Animal; Energy Metabolism; Flavoproteins; Membrane Proteins; Mitochondria; Myocardial Ischemia; Oxygen Consumption; Permeability; Protective Agents; Rats; Rats, Wistar; Reactive Oxygen Species; Reperfusion Injury | 2003 |
N-nitrosylation potential of mono-N-desethylamiodarone at physiological pH.
Topics: Amiodarone; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Nitroso Compounds | 2004 |
Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Blood Glucose; Blotting, Northern; Body Weight; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Dose-Response Relationship, Drug; Gene Expression Regulation; Genes, Reporter; Hepatocytes; Hepatomegaly; Homeostasis; Lipid Metabolism; Liver; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Knockout; PPAR alpha; Transcriptional Activation | 2004 |
Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Gene Expression Regulation; Ion Channels; Male; Mice; Mice, Inbred C57BL; Myocardium; Patch-Clamp Techniques; RNA, Messenger; Transcription, Genetic; Triiodothyronine; Triiodothyronine, Reverse | 2004 |
Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms.
Topics: Administration, Oral; Amiodarone; Animals; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Half-Life; Injections, Intravenous; Intestinal Mucosa; Intestines; Isoenzymes; Ketoconazole; Liver; Male; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2006 |
Amiodarone and N-desethylamiodarone enhance endothelial nitric oxide production in human endothelial cells.
Topics: Amiodarone; Cell Culture Techniques; Endothelium, Vascular; Gene Expression; Humans; Nitric Oxide; Nitric Oxide Synthase; Reverse Transcriptase Polymerase Chain Reaction; Vasodilator Agents | 2006 |
Uptake of amiodarone by thyroidal and non-thyroidal cell lines.
Topics: Amiodarone; Animals; Cell Line; CHO Cells; Cricetinae; Cricetulus; Iodine; Perchlorates; Potassium Compounds; Symporters; Thyroid Gland; Transfection | 2006 |
Determination of amiodarone and desethylamiodarone in horse plasma and urine by high-performance liquid chromatography combined with UV detection and electrospray ionization mass spectrometry.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Horses; Reference Standards; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet | 2006 |
Serum amiodarone and desethylamiodarone concentrations following nasogastric versus oral administration.
Topics: Administration, Oral; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Biological Availability; Dose-Response Relationship, Drug; Drug Monitoring; Female; Half-Life; Humans; Intubation, Gastrointestinal; Male; Middle Aged | 2006 |
Amiodarone analog-dependent effects on CYP2C9-mediated metabolism and kinetic profiles.
Topics: Amiodarone; Aryl Hydrocarbon Hydroxylases; Benzbromarone; Cytochrome P-450 CYP2C9; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genotype; Isoenzymes; Kinetics; Methylation; Molecular Structure; Naproxen; Phosphatidylcholines; Protein Binding; Quantitative Structure-Activity Relationship; Substrate Specificity | 2006 |
A liquid chromatography-mass spectrometry assay method for simultaneous determination of amiodarone and desethylamiodarone in rat specimens.
Topics: Amiodarone; Animals; Calibration; Chromatography, High Pressure Liquid; Injections, Intravenous; Linear Models; Molecular Structure; Phenothiazines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tissue Distribution | 2007 |
The influence of hyperlipoproteinemia on in vitro distribution of amiodarone and desethylamiodarone in human and rat plasma.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cholesterol; Humans; Hyperlipoproteinemias; Lipoproteins; Lipoproteins, LDL; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity; Triglycerides | 2007 |
Efflux transport of N-monodesethylamiodarone by the human intestinal cell-line Caco-2 cells.
Topics: Adenosine Triphosphate; Amiodarone; Biological Transport, Active; Caco-2 Cells; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Chromatography, High Pressure Liquid; Drug Interactions; Humans; Intestinal Mucosa; Intestines; Spectrophotometry, Ultraviolet; Thyroid Hormones; Uncoupling Agents | 2007 |
Pharmacokinetics of desethylamiodarone in the rat after its administration as the preformed metabolite, and after administration of amiodarone.
Topics: Administration, Oral; Amiodarone; Animals; Anti-Arrhythmia Agents; Area Under Curve; Chromatography, Liquid; Half-Life; Injections, Intravenous; Liver; Male; Mass Spectrometry; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2008 |
Direct mitochondrial dysfunction precedes reactive oxygen species production in amiodarone-induced toxicity in human peripheral lung epithelial HPL1A cells.
Topics: alpha-Tocopherol; Amiodarone; Anti-Arrhythmia Agents; Cell Line; Chromans; Cyclic N-Oxides; Cytochromes c; Cytoplasm; Epithelial Cells; Humans; Lung; Mitochondria; Reactive Oxygen Species; Ubiquinone | 2008 |
Amiodarone increases the accumulation of DEA in a human alveolar epithelium-derived cell line.
Topics: Adenosine Triphosphate; Amiodarone; Anti-Arrhythmia Agents; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Line; Cell Survival; Chromatography, High Pressure Liquid; Epithelial Cells; Humans; Pulmonary Alveoli; Spectrophotometry, Ultraviolet; Tetrazolium Salts; Thiazoles | 2008 |
The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Cytochrome P-450 Enzyme System; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hyperlipidemias; Injections, Intravenous; Male; Microsomes, Liver; Poloxamer; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2008 |
Simultaneous determination of amiodarone and its metabolite desethylamiodarone by high-performance liquid chromatography with chemiluminescent detection.
Topics: 2,2'-Dipyridyl; Amiodarone; Chromatography, High Pressure Liquid; Coordination Complexes; Humans; Luminescent Measurements; Pharmaceutical Preparations; Photochemistry; Sensitivity and Specificity; Time Factors | 2008 |
Amiodarone inhibits arterial thrombus formation and tissue factor translation.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Carotid Artery Injuries; Carotid Artery Thrombosis; Cells, Cultured; Endothelial Cells; Humans; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Protein Biosynthesis; RNA, Messenger; Thromboplastin | 2008 |
Effects of intestinal constituents and lipids on intestinal formation and pharmacokinetics of desethylamiodarone formed from amiodarone.
Topics: Administration, Oral; Amiodarone; Animals; Area Under Curve; Bile Acids and Salts; Cholesterol; Dietary Fats; Food-Drug Interactions; Intestinal Mucosa; Lecithins; Lipase; Male; Peanut Oil; Plant Oils; Rats; Rats, Sprague-Dawley; Soybean Oil; Triglycerides | 2008 |
Experimental hyperlipidemia causes an increase in the electrocardiographic changes associated with amiodarone.
Topics: Amiodarone; Animals; Cholesterol; Electrocardiography; Heart Rate; Hyperlipidemias; Injections, Intravenous; Male; Rats; Rats, Sprague-Dawley | 2009 |
Cocktail-substrate assay system for mechanism-based inhibition of CYP2C9, CYP2D6, and CYP3A using human liver microsomes at an early stage of drug development.
Topics: Amiodarone; Aryl Hydrocarbon Hydroxylases; Biological Assay; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Activation; Humans; Isoniazid; Kinetics; Microsomes, Liver; Reference Standards; Substrate Specificity; Time Factors | 2009 |
The effect of CYP1A induction on amiodarone disposition in the rat.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; beta-Naphthoflavone; Biotransformation; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Enzyme Induction; Male; Organ Specificity; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2010 |
Simultaneous measurement of amiodarone and desethylamiodarone in human plasma and serum by stable isotope dilution liquid chromatography-tandem mass spectrometry assay.
Topics: Amiodarone; Anti-Arrhythmia Agents; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Drug Monitoring; Humans; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Assessment of the inactivation potential of desethylamiodarone on human CYP1A1.
Topics: Amiodarone; Cytochrome P-450 CYP1A1; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; NADP | 2010 |
Epicardial application of an amiodarone-releasing hydrogel to suppress atrial tachyarrhythmias.
Topics: Administration, Cutaneous; Amiodarone; Animals; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disease Models, Animal; Drug Delivery Systems; Electrodes, Implanted; Goats; Heart Atria; Hydrogel, Polyethylene Glycol Dimethacrylate; Pericardium; Polyethylene Glycols; Refractory Period, Electrophysiological; Tachycardia, Ectopic Atrial | 2011 |
The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; beta-Naphthoflavone; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Kidney; Lung; Male; Microsomes; Microsomes, Liver; Rats; Rats, Sprague-Dawley | 2010 |
The role of CYP3A4 in amiodarone-associated toxicity on HepG2 cells.
Topics: Amiodarone; Anti-Arrhythmia Agents; Apoptosis; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP3A; Hep G2 Cells; Hepatocytes; Humans; Reactive Oxygen Species | 2011 |
Mechanisms of amiodarone and desethylamiodarone cytotoxicity in nontransformed human peripheral lung epithelial cells.
Topics: Amiodarone; Angiotensin II; Angiotensinogen; Anti-Arrhythmia Agents; Apoptosis; Cell Survival; Cells, Cultured; Epithelial Cells; Humans; In Situ Nick-End Labeling; Lung; Necrosis; RNA, Messenger | 2011 |
Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype.
Topics: Amiodarone; Androstenes; Animals; Anti-Arrhythmia Agents; Cells, Cultured; Cholesterol; Dose-Response Relationship, Drug; Dronedarone; Endosomes; Humans; Lysophospholipids; Molecular Structure; Monoglycerides; Niemann-Pick Diseases; Nocodazole | 2011 |
Preparation and determination of desethylamiodarone in dog lung by HPLC-MS.
Topics: Amiodarone; Animals; Chromatography, High Pressure Liquid; Dogs; Lung; Male; Mass Spectrometry; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2011 |
A liquid chromatography-electrospray tandem mass spectrometry method for the determination of antiarrhythmic drugs and their metabolites in forensic whole blood samples.
Topics: Amiodarone; Anti-Arrhythmia Agents; Calibration; Chromatography, High Pressure Liquid; Chromatography, Liquid; Forensic Toxicology; Humans; Limit of Detection; Propafenone; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
Stimulation of human monocytic THP-1 cells by metabolic activation of hepatotoxic drugs.
Topics: Albendazole; Amiodarone; B7-2 Antigen; Biotransformation; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Humans; Intercellular Adhesion Molecule-1; Interleukin-8; Ketoconazole; Leukemia, Myeloid; Microsomes, Liver; Monocytes; RNA, Messenger; Tumor Necrosis Factor-alpha; Up-Regulation | 2012 |
First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure.
Topics: Adult; Amiodarone; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Monitoring; Drug Stability; Female; Humans; Limit of Detection; Male; Reproducibility of Results | 2013 |
Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells.
Topics: Amiodarone; Cell Death; Cells, Cultured; Drug Synergism; Epithelial Cells; Humans; L-Lactate Dehydrogenase; Lung; Molecular Structure; Toxicity Tests | 2013 |
Amiodarone inhibits apamin-sensitive potassium currents.
Topics: Amiodarone; Anti-Arrhythmia Agents; Apamin; Calcium; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Intracellular Space; Patch-Clamp Techniques; Small-Conductance Calcium-Activated Potassium Channels; Ventricular Fibrillation | 2013 |
Breast milk concentrations of amiodarone, desethylamiodarone, and bisoprolol following short-term drug exposure: two case reports.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Biotransformation; Bisoprolol; Female; Humans; Milk, Human; Postpartum Period | 2014 |
Determination of the cardiac drug amiodarone and its N-desethyl metabolite in sludge samples.
Topics: Amiodarone; Cardiovascular Agents; Chromatography, Liquid; Environmental Pollutants; Sewage; Spain; Tandem Mass Spectrometry | 2015 |
Long-term pretreatment with desethylamiodarone (DEA) or amiodarone (AMIO) protects against coronary artery occlusion induced ventricular arrhythmias in conscious rats.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cardiotonic Agents; Consciousness; Coronary Occlusion; Male; Myocardium; Rats | 2015 |
A Physiologically Based Pharmacokinetic Model of Amiodarone and its Metabolite Desethylamiodarone in Rats: Pooled Analysis of Published Data.
Topics: Algorithms; Amiodarone; Animals; Anti-Arrhythmia Agents; Biotransformation; Blood-Brain Barrier; Cytochrome P-450 Enzyme Inhibitors; Dose-Response Relationship, Drug; Ether-A-Go-Go Potassium Channels; Half-Life; Infusions, Intravenous; Injections, Intravenous; Male; Metabolic Clearance Rate; Microsomes, Liver; Models, Biological; Potassium Channel Blockers; Rats; Tissue Distribution | 2016 |
Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites.
Topics: Activation, Metabolic; Amiodarone; Animals; Anti-Arrhythmia Agents; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decarboxylation; Dronedarone; Humans; Insecta; Kinetics; Microsomes; Models, Molecular; Molecular Structure; NADP; Oxidation-Reduction; Prodrugs; Recombinant Proteins; Substrate Specificity | 2016 |
The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.
Topics: Activation, Metabolic; Amiodarone; Anti-Arrhythmia Agents; Benzoflavones; Cell Survival; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Ketoconazole; Time Factors; Transfection | 2016 |
Association between N-desethylamiodarone/amiodarone ratio and amiodarone-induced thyroid dysfunction.
Topics: Amiodarone; Female; Humans; Hyperthyroidism; Hypothyroidism; Male; Retrospective Studies; Thyrotropin; Thyroxine | 2017 |
Association between Serum Amiodarone and N-Desethylamiodarone Concentrations and Development of Thyroid Dysfunction.
Topics: Adult; Aged; Aged, 80 and over; Amiodarone; Anti-Arrhythmia Agents; Female; Humans; Hypothyroidism; Male; Middle Aged; Retrospective Studies; Thyrotoxicosis; Thyrotropin; Thyroxine; Triiodothyronine | 2018 |
Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways.
Topics: Amiodarone; Apoptosis; Cell Line, Tumor; Humans; Membrane Potential, Mitochondrial; Urinary Bladder Neoplasms | 2017 |
Amiodarone's major metabolite, desethylamiodarone, induces apoptosis in human cervical cancer cells.
Topics: Amiodarone; Apoptosis; Cell Cycle Checkpoints; Female; HeLa Cells; Humans; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Uterine Cervical Neoplasms | 2018 |
Amiodarone's major metabolite, desethylamiodarone inhibits proliferation of B16-F10 melanoma cells and limits lung metastasis formation in an in vivo experimental model.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Proliferation; Lung Neoplasms; Male; Melanoma, Experimental; Mice; Mice, Inbred C57BL; Skin Neoplasms | 2020 |
Involvement of Mitochondrial Mechanisms in the Cytostatic Effect of Desethylamiodarone in B16F10 Melanoma Cells.
Topics: Amiodarone; Animals; Apoptosis; Apoptosis Inducing Factor; Cell Proliferation; Cytochromes c; Cytostatic Agents; Energy Metabolism; Humans; Lung; Melanoma, Experimental; Membrane Potential, Mitochondrial; Mice; Mitochondria; Oxygen Consumption; Permeability; Reactive Oxygen Species | 2020 |
Analysis of Live Single Cells by Confocal Microscopy and High-Resolution Mass Spectrometry to Study Drug Uptake, Metabolism, and Drug-Induced Phospholipidosis.
Topics: Amiodarone; Hep G2 Cells; Humans; Lysosomal Storage Diseases; Mass Spectrometry; Microscopy, Confocal; Single-Cell Analysis | 2020 |
Quantitation of amiodarone and N-desethylamiodarone in single HepG2 cells by single-cell printing-liquid vortex capture-mass spectrometry.
Topics: Amiodarone; Hep G2 Cells; Humans; Mass Spectrometry; Reproducibility of Results; Single-Cell Analysis; Vasodilator Agents | 2021 |
In vivo and cellular antiarrhythmic and cardiac electrophysiological effects of desethylamiodarone in dog cardiac preparations.
Topics: Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Fibrillation; Dogs; Heart Atria; Myocytes, Cardiac | 2022 |
Involvement of Mitochondrial Mechanisms and Cyclooxygenase-2 Activation in the Effect of Desethylamiodarone on 4T1 Triple-Negative Breast Cancer Line.
Topics: Amiodarone; Animals; Antineoplastic Agents; Celecoxib; Cell Line, Tumor; Cell Movement; Cell Survival; Cyclooxygenase 2; Drug Resistance, Neoplasm; Drug Synergism; Energy Metabolism; Enzyme Activation; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Mice; Mitochondria; Triple Negative Breast Neoplasms; Up-Regulation | 2022 |
Population Pharmacokinetic Model of Amiodarone and N-Desethylamiodarone Focusing on Glucocorticoid and Inflammation.
Topics: Adult; Amiodarone; Anti-Arrhythmia Agents; Cytochrome P-450 CYP3A; Glucocorticoids; Humans; Inflammation; Pilot Projects; Retrospective Studies | 2022 |
Amiodarone/N-desethylamiodarone population pharmacokinetics in paediatric patients.
Topics: Administration, Oral; Amiodarone; Biological Availability; Child; Chromatography, Liquid; Humans | 2022 |