amiodarone and chloroquine

amiodarone has been researched along with chloroquine in 38 studies

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19905 (13.16)18.7374
1990's3 (7.89)18.2507
2000's9 (23.68)29.6817
2010's19 (50.00)24.3611
2020's2 (5.26)2.80

Authors

AuthorsStudies
Topliss, JG; Yoshida, F1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ1
Glen, RC; Lowe, R; Mitchell, JB1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Sen, S; Sinha, N1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Atzpodien, EA; Csato, M; Doessegger, L; Fischer, H; Lenz, B; Schmitt, G; Singer, T1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Jones, LH; Nadanaciva, S; Rana, P; Will, Y1
Blank, BR; Gut, J; Renslo, AR; Rosenthal, PJ1
Kivistö, KT; Laine, K; Neuvonen, PJ1
Jaanus, SD1
Anderson, SN; Kacew, S; Ruben, Z1
Butany, J; Downar, E; Shaikh, NA1
George, JL1
Coudert, B; Dwyer, TM; Joshi, UM; Kodavanti, PR; Mehendale, HM1
D'Amico, DJ; Kenyon, KR1
Lüllmann-Rauch, R1
Kumamoto, T1
Bradley, KA; Damoiseaux, R; Gillespie, EJ; Huang, J; Manchester, M; Rogers, J; Sanchez, AM; Saxe, JP; Thomas, D1
Ikebe, T; Ikewaki, J; Imaizumi, M; Nakatsuka, K1
Bittner, T; Brouwers, N; Capell, A; Carlson, AM; Cruts, M; Dormann, D; Fellerer, K; Gijselinck, I; Haass, C; Herms, J; Jansen, R; Kunze, B; Lammich, S; Liebscher, S; Sasse, F; Sleegers, K; Steinmetz, H; Van Broeckhoven, C; Willem, M1
Brouwer, KL; Ferslew, BC1
Chen, YJ; Chen, YS; Chung, WL; Dai, CY; Huang, JF; Kuo, PL; Lee, PH; Lin, CC; Lin, CW; Lo, GH; Yu, ML1
Marceau, F; Parks, A1
Koizumi, H; Kurata, M; Nemoto, S; Satoh, H; Takei, Y; Yamagiwa, Y1
Eguchi, A; Ichikawa, R; Masuda, S; Mizukami, S; Nakamura, K; Nakamura, M; Okada, R; Shibutani, M; Tanaka, T; Yoshida, T1
Bantel, H; Frangež, Ž; John, K; Liebig, S; Pfeffer, TJ; Schulze-Osthoff, K; Shibolet, O; Simon, HU; Veltmann, C; Vondran, F; Wandrer, F; Wedemeyer, H1
Absenger-Novak, M; Fröhlich, E; Meindl, C; Ober, J; Öhlinger, K1

Reviews

5 review(s) available for amiodarone and chloroquine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Ocular side effects of selected systemic drugs.
    Optometry clinics : the official publication of the Prentice Society, 1992, Volume: 2, Issue:4

    Topics: Amiodarone; Anti-Inflammatory Agents; Antirheumatic Agents; Chloroquine; Chlorpromazine; Drug Interactions; Eye Diseases; Humans; Organogold Compounds; Steroids; Sulfonamides; Vision Disorders

1992
Experimentally induced lipidosis in rat retinal pigment epithelium. A brief review.
    Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology, 1981, Volume: 215, Issue:4

    Topics: Amiodarone; Animals; Chloroquine; Chlorphentermine; Imipramine; Lipidoses; Microscopy, Electron; Perhexiline; Pigment Epithelium of Eye; Rats

1981
[Amphiphilic cationic drug myopathy, drug-induced lysosomal storage lipidosis].
    Ryoikibetsu shokogun shirizu, 2001, Issue:36

    Topics: Aminoquinolines; Amiodarone; Animals; Anti-Arrhythmia Agents; Antimalarials; Autophagy; Cations; Chloroquine; Diagnosis, Differential; Humans; Hydroxychloroquine; Lysosomes; Muscle, Skeletal; Muscular Diseases; Perhexiline; Prognosis; Vacuoles

2001
[Drug-induced visual disturbance].
    Nihon rinsho. Japanese journal of clinical medicine, 2007, Oct-28, Volume: 65 Suppl 8

    Topics: Amiodarone; Anti-Asthmatic Agents; Antimalarials; Antitubercular Agents; Antiviral Agents; Chloroquine; Chlorpromazine; Dopamine Antagonists; Ethambutol; Eye Diseases; Glucocorticoids; Humans; Interferons; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones

2007

Trials

1 trial(s) available for amiodarone and chloroquine

ArticleYear
Failure of oral activated charcoal to accelerate the elimination of amiodarone and chloroquine.
    Human & experimental toxicology, 1992, Volume: 11, Issue:6

    Topics: Administration, Oral; Amiodarone; Animals; Charcoal; Chloroquine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration Schedule; Half-Life; Male; Metabolic Clearance Rate; Rats; Rats, Sprague-Dawley

1992

Other Studies

32 other study(ies) available for amiodarone and chloroquine

ArticleYear
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species.
    Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6

    Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
In silico assay for assessing phospholipidosis potential of small druglike molecules: training, validation, and refinement using several data sets.
    Journal of medicinal chemistry, 2012, Jan-12, Volume: 55, Issue:1

    Topics: Animals; Cattle; Cells, Cultured; Computer Simulation; Cornea; Drug-Related Side Effects and Adverse Reactions; Fibroblasts; Lipidoses; Lysosomal Storage Diseases; Models, Molecular; Pharmaceutical Preparations; Phospholipids; Structure-Activity Relationship; Thermodynamics

2012
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
    Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10

    Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding

2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Development of a cell viability assay to assess drug metabolite structure-toxicity relationships.
    Bioorganic & medicinal chemistry letters, 2016, 08-15, Volume: 26, Issue:16

    Topics: Adenosine Triphosphate; Benzbromarone; Cell Line; Cell Survival; Chromans; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Humans; Pharmaceutical Preparations; Thiazolidinediones; Troglitazone

2016
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane.
    Journal of medicinal chemistry, 2017, 07-27, Volume: 60, Issue:14

    Topics: Animals; Antimalarials; Female; Ferrous Compounds; Heterocyclic Compounds, 1-Ring; Malaria; Mice; Peroxides; Plasmodium berghei; Plasmodium falciparum; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship

2017
Changes in saccharide and phospholipid content associated with drug storage in cultured rabbit aorta muscle cells.
    Laboratory investigation; a journal of technical methods and pathology, 1991, Volume: 64, Issue:4

    Topics: Amines; Amiodarone; Animals; Anti-Arrhythmia Agents; Aorta; Cells, Cultured; Chloroquine; Desipramine; Ethylenediamines; Kinetics; Microscopy, Electron; Monosaccharides; Muscle, Smooth, Vascular; Phospholipids; Piperidines; Rabbits; Tilorone

1991
Amiodarone--an inhibitor of phospholipase activity: a comparative study of the inhibitory effects of amiodarone, chloroquine and chlorpromazine.
    Molecular and cellular biochemistry, 1987, Volume: 76, Issue:2

    Topics: Amiodarone; Chloroquine; Chlorpromazine; Humans; Inclusion Bodies; Leukocytes; Microscopy, Electron; Phospholipases

1987
[Corneal, conjunctival and lacrimal changes (excluding dry eye)].
    Bulletin des societes d'ophtalmologie de France, 1985, Volume: Spec No

    Topics: Adrenal Cortex Hormones; Amiodarone; Anesthetics, Local; Anti-Bacterial Agents; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; Chloroquine; Conjunctival Diseases; Contact Lenses; Corneal Diseases; Drug Hypersensitivity; Humans; Lacrimal Apparatus Diseases; Ophthalmic Solutions; Phenothiazines; Pigmentation Disorders

1985
Types of interaction of amphiphilic drugs with phospholipid vesicles.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 246, Issue:1

    Topics: Amiodarone; Anilino Naphthalenesulfonates; Binding Sites; Chloramphenicol; Chloroquine; Chlorpromazine; Diphenylhexatriene; Imipramine; Lipidoses; Lung Diseases; Membrane Lipids; Phospholipids; Promethazine; Propranolol; Surface-Active Agents; Trimipramine

1988
Drug-induced lipidoses of the cornea and conjunctiva.
    International ophthalmology, 1981, Volume: 4, Issue:1-2

    Topics: Amiodarone; Amodiaquine; Chloroquine; Conjunctival Diseases; Corneal Diseases; Fabry Disease; Female; Gentamicins; Humans; Hydroquinones; Lipidoses; Male; Tilorone

1981
Amiodarone and bepridil inhibit anthrax toxin entry into host cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7

    Topics: Amiodarone; Animals; Anthrax; Antigens, Bacterial; Bacterial Toxins; Bepridil; Cell Line; Cell Survival; Chloroquine; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Macrophages, Peritoneal; Male; Mice; Molecular Structure; Rats; Rats, Inbred F344; Time Factors

2007
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Feb-02, Volume: 31, Issue:5

    Topics: Alkalies; Amiodarone; Animals; Animals, Newborn; Autophagy-Related Protein 5; Bepridil; Blotting, Northern; Bridged Bicyclo Compounds, Heterocyclic; Cells, Cultured; Cerebral Cortex; Chloroquine; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Frontotemporal Lobar Degeneration; Granulins; HEK293 Cells; HeLa Cells; Humans; Intercellular Signaling Peptides and Proteins; Macrolides; Male; Mice; Microtubule-Associated Proteins; Mutation; Neurons; Progranulins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Vacuolar Proton-Translocating ATPases

2011
Identification of hepatic phospholipidosis inducers in sandwich-cultured rat hepatocytes, a physiologically relevant model, reveals altered basolateral uptake and biliary excretion of anionic probe substrates.
    Toxicological sciences : an official journal of the Society of Toxicology, 2014, Volume: 139, Issue:1

    Topics: Amiodarone; Animals; Anions; Azithromycin; Biliary Tract; Cells, Cultured; Chloroquine; Desipramine; Fluorobenzenes; Gentamicins; Hepatocytes; Male; Models, Biological; Phospholipids; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Taurocholic Acid

2014
Amiodarone as an autophagy promoter reduces liver injury and enhances liver regeneration and survival in mice after partial hepatectomy.
    Scientific reports, 2015, Oct-30, Volume: 5

    Topics: Amiodarone; Animals; Autophagy; Autophagy-Related Protein 7; Chloroquine; Disease Models, Animal; Hepatectomy; Interleukin-6; Interleukin-8; Liver Diseases; Liver Regeneration; Male; Membrane Potential, Mitochondrial; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondria; RNA Interference; Signal Transduction; Survival Rate; TOR Serine-Threonine Kinases

2015
Lysosomotropic cationic drugs induce cytostatic and cytotoxic effects: Role of liposolubility and autophagic flux and antagonism by cholesterol ablation.
    Toxicology and applied pharmacology, 2016, 08-15, Volume: 305

    Topics: Amiodarone; Anticholesteremic Agents; Autophagy; beta-Cyclodextrins; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Chloroquine; Cholesterol; Cytostatic Agents; Cytotoxins; Human Umbilical Vein Endothelial Cells; Humans; Hydroxychloroquine; Lidocaine; Lovastatin; Lysosomes; Microtubule-Associated Proteins; Poly (ADP-Ribose) Polymerase-1; Procainamide; Quinacrine

2016
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone.
    Toxicologic pathology, 2019, Volume: 47, Issue:1

    Topics: Administration, Ophthalmic; Aging; Amiodarone; Animals; Chloroquine; Cornea; Disease Models, Animal; Female; Inclusion Bodies; Instillation, Drug; Lipidoses; Male; Phospholipids; Rabbits

2019
Immunohistochemical expression of autophagosome markers LC3 and p62 in preneoplastic liver foci in high fat diet-fed rats.
    The Journal of toxicological sciences, 2019, Volume: 44, Issue:8

    Topics: Amiodarone; Animals; Autophagosomes; Autophagy; Autophagy-Related Protein 5; Chloroquine; Diet, High-Fat; Disease Models, Animal; Gene Expression; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Male; Microtubule-Associated Proteins; Non-alcoholic Fatty Liver Disease; Precancerous Conditions; Rats, Inbred F344; RNA-Binding Proteins

2019
Autophagy alleviates amiodarone-induced hepatotoxicity.
    Archives of toxicology, 2020, Volume: 94, Issue:10

    Topics: Aged; Amiodarone; Anti-Arrhythmia Agents; Apoptosis; Autophagy; Cell Survival; Cells, Cultured; Chemical and Drug Induced Liver Injury; Chloroquine; CRISPR-Cas Systems; Endoplasmic Reticulum Stress; Female; Gene Knockout Techniques; Hep G2 Cells; Hepatocytes; Humans; Keratin-18; Lipid Metabolism; Male

2020
Different Sensitivity of Macrophages to Phospholipidosis Induction by Amphiphilic Cationic Drugs.
    International journal of molecular sciences, 2020, Nov-09, Volume: 21, Issue:21

    Topics: Amiodarone; Animals; Cations; Cell Line; Chloroquine; Humans; Lysosomal Storage Diseases; Macrophages; Mice; Monocytes; Phospholipids; RAW 264.7 Cells; THP-1 Cells

2020