amiodarone and acetaminophen

amiodarone has been researched along with acetaminophen in 44 studies

Research

Studies (44)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (6.82)	18.7374
1990's	0 (0.00)	18.2507
2000's	18 (40.91)	29.6817
2010's	22 (50.00)	24.3611
2020's	1 (2.27)	2.80

Authors

Authors	Studies
Topliss, JG; Yoshida, F	1
Gao, F; Lombardo, F; Shalaeva, MY; Tupper, KA	1
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	2
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Andricopulo, AD; Moda, TL; Montanari, CA	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
García-Mera, X; González-Díaz, H; Prado-Prado, FJ	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Glen, RC; Lowe, R; Mitchell, JB	1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Chong, MT; Svensson, CK	1
Lauterburg, BH	1
D'Arcy, PF	1
Bagchi, D; Patel, D; Ray, SD; Wong, V	1
Bagchi, D; Bagchi, M; Preuss, HG; Ray, SD; Stohs, SJ	1
Horii, I; Kikkawa, R; Yamada, H; Yamamoto, T	2
Aninat, C; Glaise, D; Guguen-Guillouzo, C; Guillouzo, A; Langouët, S; Le Charpentier, T; Morel, F; Piton, A	1
Fujikawa, M; Hamada, Y; Horii, I; Kikkawa, R; Yamada, H; Yamamoto, T	1
Abel, K; Hisatomi, K; Ide, M; Ishii, H; Ishimatsu, Y; Ishimoto, H; Kohno, S; Mukae, H; Nakayama, S; Ozono, Y; Sugiyama, K	1
Fukushima, T; Hamada, Y; Horii, I; Kikkawa, R	1
Azarpira, N; Baghban, M; Jamshidzadeh, A; Mohammadi Bardbori, A; Niknahad, H	1
Bouwman, FG; Kleinjans, JC; Mariman, EC; Noben, JP; Renes, J; van Delft, JH; Van Summeren, A	1
Jaeschke, H; McGill, MR; Ramachandran, A	1
Fey, SJ; Wrzesinski, K	1
Colatsky, T; Mans, D; Rosenzweig, BA; Shea, K; Stewart, S; Thompson, KL; Zhang, J	1
Bouwman, FG; Kleinjans, JC; Lizarraga, D; Mariman, EC; Noben, JP; Renes, J; van Delft, JH; Van Summeren, A	1
Borlak, J; Chougule, A; Singh, PK	1
Chang, SY; Chen, CJ; Chen, CY; Chen, JJ; Chen, WC; Cheng, CH; Hung, DZ; Lim, YP; Lin, YH; Ma, WC; Nakajima, M; Wan, L; Yokoi, T	1
Driessen, M; Kienhuis, AS; Pennings, JL; van der Ven, LT; Vitins, AP; Water, Bv	1
Bavli, D; Cohen, M; Duschl, C; Ezra, E; Jaeger, MS; Levy, G; Nahmias, Y; Prill, S; Schmälzlin, E; Schwarz, M	1
Berckmans, P; Covaci, A; Hollanders, K; Maho, W; Peers, B; Remy, S; Verstraelen, S; Witters, H	1
Li, AP; Wei, H	1

Reviews

2 review(s) available for amiodarone and acetaminophen

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Drug damage to the liver: role of reactive metabolites and pharmacokinetics]. Schweizerische medizinische Wochenschrift, 1985, Sep-21, Volume: 115, Issue:38 Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Drug-Related Side Effects and Adverse Reactions; Erythromycin; Glutathione; Halothane; Humans; Isoniazid; Liver; Perhexiline; Valproic Acid	1985

Other Studies

42 other study(ies) available for amiodarone and acetaminophen

Article	Year
QSAR model for drug human oral bioavailability. Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13 Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship	2000
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry, 2001, Jul-19, Volume: 44, Issue:15 Topics: 1-Octanol; Chromatography, High Pressure Liquid; Pharmaceutical Preparations; Solubility; Water	2001
Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data. Journal of medicinal chemistry, 2002, Jun-20, Volume: 45, Issue:13 Topics: Blood Proteins; Chemical Phenomena; Chemistry, Physical; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding	2002
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Hologram QSAR model for the prediction of human oral bioavailability. Bioorganic & medicinal chemistry, 2007, Dec-15, Volume: 15, Issue:24 Topics: Administration, Oral; Biological Availability; Holography; Humans; Models, Biological; Models, Molecular; Molecular Structure; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2007
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models. Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3 Topics:	2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
Multi-target spectral moment QSAR versus ANN for antiparasitic drugs against different parasite species. Bioorganic & medicinal chemistry, 2010, Mar-15, Volume: 18, Issue:6 Topics: Antiparasitic Agents; Molecular Structure; Neural Networks, Computer; Parasitic Diseases; Quantitative Structure-Activity Relationship; Species Specificity; Thermodynamics	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
Predicting phospholipidosis using machine learning. Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5 Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine	2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Effect of amiodarone on the disposition of acetaminophen in the rat. Journal of pharmaceutical sciences, 1989, Volume: 78, Issue:11 Topics: Acetaminophen; Amiodarone; Animals; Drug Interactions; Glucuronates; Male; Rats; Rats, Inbred Strains; Sulfates	1989
Early reports on drug interactions. Drug intelligence & clinical pharmacy, 1983, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Apazone; Aspirin; Carbamazepine; Chlordiazepoxide; Cimetidine; Coumarins; Drug Interactions; Erythromycin; Ethanol; Furosemide; Gentamicins; Humans; Levodopa; Lidocaine; Phenytoin; Prenylamine; Quinidine	1983
In vivo protection of dna damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract. Research communications in molecular pathology and pharmacology, 2000, Volume: 107, Issue:1-2 Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Animals; Antioxidants; Apoptosis; Blood Urea Nitrogen; Creatine Kinase; DNA Fragmentation; Doxorubicin; Free Radical Scavengers; Grape Seed Extract; Heart Diseases; Injections, Intraperitoneal; Kidney Diseases; Lung Diseases; Male; Mice; Necrosis; Plant Extracts; Proanthocyanidins; Rosales	2000
Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. Indian journal of experimental biology, 2002, Volume: 40, Issue:6 Topics: Acetaminophen; Administration, Oral; Alanine Transaminase; Amiodarone; Analgesics, Non-Narcotic; Animals; Antineoplastic Agents; Antioxidants; Apoptosis; Blood Urea Nitrogen; Cell Cycle; Creatine Kinase; Dimethylnitrosamine; DNA Damage; Doxorubicin; Drug-Related Side Effects and Adverse Reactions; Free Radical Scavengers; Grape Seed Extract; Heart Diseases; Humans; In Vitro Techniques; Injections, Intraperitoneal; Keratinocytes; Kidney Diseases; Lipid Peroxidation; Lung Diseases; Mice; Mice, Inbred ICR; Necrosis; Oxidation-Reduction; Plant Extracts; Proanthocyanidins; Spleen; Tobacco, Smokeless; Vasodilator Agents	2002
Identification of oxidative stress-related proteins for predictive screening of hepatotoxicity using a proteomic approach. The Journal of toxicological sciences, 2005, Volume: 30, Issue:3 Topics: Acetaminophen; Amiodarone; Animals; Cells, Cultured; Down-Regulation; Electrophoresis, Gel, Two-Dimensional; Hepatocytes; Male; Mass Spectrometry; Oxidative Stress; Proteins; Proteomics; Rats; Rats, Sprague-Dawley; Tetracycline; Time Factors; Up-Regulation	2005
Expression of cytochromes P450, conjugating enzymes and nuclear receptors in human hepatoma HepaRG cells. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:1 Topics: Acetaminophen; Aflatoxin B1; Amiodarone; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Chlorpromazine; Cytochrome P-450 Enzyme System; Dimethyl Sulfoxide; Gene Expression; Gene Expression Profiling; Glucuronosyltransferase; Hepatocytes; Humans; Inhibitory Concentration 50; Isoenzymes; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Xenobiotics	2006
In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system. The Journal of toxicological sciences, 2006, Volume: 31, Issue:1 Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Carbon Tetrachloride; Cells, Cultured; Hepatocytes; Kupffer Cells; Liver; Male; Oxidative Stress; Proteins; Proteomics; Rats; Rats, Inbred Strains; Tetracycline; Toxicity Tests	2006
Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants. The Journal of toxicological sciences, 2006, Volume: 31, Issue:1 Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Carbon Tetrachloride; Liver; Male; Proteins; Proteomics; Rats; Rats, Inbred Strains; Tetracycline	2006
[A case of rheumatoid lung complicated by SELAPINA-induced pneumonia]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society, 2006, Volume: 44, Issue:11 Topics: Acetaminophen; Aged; Amiodarone; Arthritis, Rheumatoid; Drug Combinations; Female; Humans; Lung Diseases; Pneumonia; Rheumatic Diseases	2006
Genomic cluster and network analysis for predictive screening for hepatotoxicity. The Journal of toxicological sciences, 2006, Volume: 31, Issue:5 Topics: Acetaminophen; Amiodarone; Animals; Carbon Tetrachloride; Cluster Analysis; Gene Expression; Gene Expression Profiling; Liver; Male; Oligonucleotide Array Sequence Analysis; Rats; Rats, Inbred Strains; Tetracycline	2006
Effects of tomato extract on oxidative stress induced toxicity in different organs of rats. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2008, Volume: 46, Issue:12 Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cyclosporine; Glutathione; Immunosuppressive Agents; Kidney Diseases; Lipid Peroxidation; Lung Diseases; Male; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley; Solanum lycopersicum	2008
Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 120, Issue:1 Topics: Acetaminophen; Amiodarone; Blotting, Western; Cell Survival; Chemical and Drug Induced Liver Injury; Cluster Analysis; Cyclosporine; Drug-Related Side Effects and Adverse Reactions; Electrophoresis, Gel, Two-Dimensional; Hep G2 Cells; Humans; Pharmaceutical Preparations; Protein Biosynthesis; Protein Processing, Post-Translational; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tandem Mass Spectrometry	2011
Pathophysiological relevance of proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 121, Issue:2 Topics: Acetaminophen; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclosporine; Gene Expression Regulation; Hep G2 Cells; Hepatocytes; Humans; Proteomics	2011
Determination of drug toxicity using 3D spheroids constructed from an immortal human hepatocyte cell line. Toxicological sciences : an official journal of the Society of Toxicology, 2012, Volume: 127, Issue:2 Topics: Acetaminophen; Adenosine Triphosphate; Amiodarone; Bioreactors; Diclofenac; Dose-Response Relationship, Drug; Hep G2 Cells; Hepatocytes; Humans; Lethal Dose 50; Metformin; Phenformin; Proteins; Reproducibility of Results; Risk Assessment; Spheroids, Cellular; Toxicity Tests; Valproic Acid	2012
Comparison of urinary and serum levels of di-22:6-bis(monoacylglycerol)phosphate as noninvasive biomarkers of phospholipidosis in rats. Toxicology letters, 2012, Sep-03, Volume: 213, Issue:2 Topics: Acetaminophen; Amiodarone; Animals; Biomarkers; Chemical and Drug Induced Liver Injury; Histocytochemistry; Lipidoses; Lysophospholipids; Male; Microscopy, Electron, Transmission; Phospholipids; Rats; Rats, Inbred F344	2012
Screening for drug-induced hepatotoxicity in primary mouse hepatocytes using acetaminophen, amiodarone, and cyclosporin a as model compounds: an omics-guided approach. Omics : a journal of integrative biology, 2013, Volume: 17, Issue:2 Topics: Acetaminophen; Amiodarone; Animals; Cell Line; Cluster Analysis; Cyclosporine; Gene Expression Profiling; Gene Expression Regulation; Genomics; Hep G2 Cells; Hepatocytes; Humans; Male; Mice; Primary Cell Culture; Proteome; Proteomics	2013
How useful are clinical liver function tests in in vitro human hepatotoxicity assays? Toxicology in vitro : an international journal published in association with BIBRA, 2014, Volume: 28, Issue:5 Topics: Acetaminophen; Alanine Transaminase; Albumins; Alkaline Phosphatase; Amiodarone; Aspartate Aminotransferases; Biological Assay; Chemical and Drug Induced Liver Injury; gamma-Glutamyltransferase; Hep G2 Cells; Hepatocytes; Humans; L-Lactate Dehydrogenase; Liver Function Tests; Petasites; Plant Extracts; Rifampin; Urea	2014
Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity. Archives of toxicology, 2015, Volume: 89, Issue:1 Topics: Acetaminophen; Amiodarone; Animals; Blotting, Western; Cell Differentiation; Cell Line, Tumor; Cell Survival; Constitutive Androstane Receptor; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP3A; Gene Expression Regulation, Enzymologic; Humans; Isothiocyanates; Mice; Pregnane X Receptor; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; Transcriptional Activation; Transfection	2015
A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen. Toxicology letters, 2015, Jan-22, Volume: 232, Issue:2 Topics: Acetaminophen; Amiodarone; Analgesics, Non-Narcotic; Animals; Anti-Arrhythmia Agents; Chemical and Drug Induced Liver Injury; Cyclosporine; Embryo, Nonmammalian; Gene Expression; Hepatocytes; Humans; Immunosuppressive Agents; In Vitro Techniques; Mice; Mice, Inbred C57BL; Rats; Transcriptome; Zebrafish	2015
Real-time monitoring of oxygen uptake in hepatic bioreactor shows CYP450-independent mitochondrial toxicity of acetaminophen and amiodarone. Archives of toxicology, 2016, Volume: 90, Issue:5 Topics: Acetaminophen; Activation, Metabolic; Amiodarone; Analgesics, Non-Narcotic; Anti-Arrhythmia Agents; Biomarkers; Bioreactors; Cellular Microenvironment; Chemical and Drug Induced Liver Injury; Coculture Techniques; Cytochrome P-450 CYP2E1; Dose-Response Relationship, Drug; Equipment Design; Hep G2 Cells; Hepatocytes; Humans; Lab-On-A-Chip Devices; Mitochondria, Liver; Oxygen Consumption; Spheroids, Cellular; Time Factors	2016
Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity. Journal of applied toxicology : JAT, 2016, Volume: 36, Issue:9 Topics: Acetaminophen; Amiodarone; Animals; Apoptosis; Aryl Hydrocarbon Hydroxylases; Ceruloplasmin; Coumarins; Female; Gene Expression Regulation; Genetic Markers; Genome-Wide Association Study; Humans; In Situ Hybridization; Larva; Liver; Male; Methapyrilene; Nitriles; Oxidoreductases, N-Demethylating; Phenotype; Toxicity Tests; Transferrin; Triazoles; Zebrafish; Zebrafish Proteins	2016
Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results w Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:2 Topics: Acetaminophen; Activation, Metabolic; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclophosphamide; Cytochrome P-450 Enzyme System; Glutathione; HEK293 Cells; Hepatocytes; Humans; Ketoconazole; Piperazines; Triazoles; Troglitazone	2022