aminopyrine has been researched along with metyrapone in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (81.82) | 18.7374 |
| 1990's | 1 (4.55) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Klinger, W; Muller, D | 1 |
| Pelkonen, O | 1 |
| Agosin, M; Capdevila, J; Naquira, C; Paulin, J | 1 |
| Chen, NQ; Holtzman, JL; Srivastava, SP | 1 |
| Beyerinck, RA; Brass, EP; Garrity, MJ | 1 |
| Funae, Y; Imaoka, S; Inoue, K | 1 |
| Bartsch, H; Hietanen, E; Kobljakov, V | 1 |
| Brandt, I; Klasson-Wehler, E; Lund, BO | 1 |
| Kajuschke, K; Netter, KJ | 1 |
| Hildebrandt, AG; Roots, I | 2 |
| Jenner, S; Kajuschke, K; Netter, KJ | 1 |
| Leibman, KC | 1 |
| Feuer, G; Lumb, G; Moddel, G; Sosa-Lucero, JC | 1 |
| Hildebrandt, AG | 1 |
| Netter, KJ | 1 |
| Komai, T; Sies, H; Wefers, H | 1 |
| Ashley, PL; Griffin, BW | 1 |
| Kitagawa, H; Naminohira, S; Saito, H; Sakai, T; Ueno, K | 1 |
| Linster, CL; Van Schaftingen, E | 2 |
22 other study(ies) available for aminopyrine and metyrapone
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Developmental aspects of xenobiotic transformation.
Topics: Aminopyrine; Aniline Compounds; Animals; Biotransformation; Cytochrome P-450 Enzyme System; Cytochrome Reductases; Ethylmorphine; Female; Glucosephosphates; Hexobarbital; Hydrogen-Ion Concentration; Metyrapone; Microsomes, Liver; NAD; NADP; Niacinamide; Oxidoreductases, N-Demethylating; Oxidoreductases, O-Demethylating; Phenobarbital; Pregnancy; Rats; Semicarbazides | 1976 |
Differential inhibition of aryl hydrocarbon hydroxylase in human foetal liver, adrenal gland and placenta*.
Topics: Adrenal Glands; Aminopyrine; Animals; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme System; Female; Flavonoids; Humans; Liver; Male; Maternal-Fetal Exchange; Metyrapone; Placenta; Pregnancy; Proadifen; Rats; Smoking; Testosterone | 1977 |
Cytochrome P-450 and drug metabolism in Trypanosoma cruzi: effects of phenobarbital.
Topics: Aminopyrine; Aniline Compounds; Animals; Anisoles; Carbon Monoxide; Cytochrome P-450 Enzyme System; Metyrapone; Microsomes; Mixed Function Oxygenases; Oxidoreductases, O-Demethylating; Phenobarbital; Proadifen; Ribosomes; Trypanosoma cruzi | 1976 |
The effect of substrates and inhibitors of cytochrome P-450 on the NADPH inhibition of the ATP-dependent, hepatic, microsomal calcium pump.
Topics: Aminopyrine; Animals; Benzphetamine; Calcium; Calcium-Transporting ATPases; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Imidazoles; Male; Metyrapone; Microsomes, Liver; NADP; Oxidation-Reduction; Proadifen; Rats; Rats, Inbred Strains | 1990 |
Inhibition of prostaglandin E2 catabolism and potentiation of hepatic prostaglandin E2 action in rat hepatocytes by inhibitors of oxidative metabolism.
Topics: Aminopyrine; Animals; Benzoflavones; Dinoprostone; Glucagon; Glycogen; Liver; Male; Metyrapone; Oxidation-Reduction; Proadifen; Prostaglandins E; Rats; Rats, Inbred Strains | 1988 |
Aminopyrine metabolism by multiple forms of cytochrome P-450 from rat liver microsomes: simultaneous quantitation of four aminopyrine metabolites by high-performance liquid chromatography.
Topics: Aminopyrine; Ampyrone; Animals; Antipyrine; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dipyrone; Female; Kinetics; Male; Methylcholanthrene; Metyrapone; Microsomes, Liver; Phenobarbital; Pyrazolones; Rats; Rats, Inbred Strains | 1988 |
Role of different cytochrome P-450 isozymes in the demethylation of various substrates.
Topics: 1,2-Dimethylhydrazine; Aminopyrine; Animals; Cytochrome P-450 Enzyme System; Dimethylhydrazines; Dimethylnitrosamine; In Vitro Techniques; Isoenzymes; Male; Metyrapone; Microsomes, Liver; Oxidoreductases, N-Demethylating; Proadifen; Rats; Substrate Specificity | 1986 |
o,p'-DDD in the mouse lung: selective uptake, covalent binding and effect on drug metabolism.
Topics: Adipose Tissue; Adrenal Glands; Aminopyrine; Animals; Autoradiography; Benzoflavones; beta-Naphthoflavone; DDT; Dose-Response Relationship, Drug; Isomerism; Liver; Lung; Maleates; Metyrapone; Mice; Mice, Inbred C57BL; Mitotane; Phenobarbital; Pulmonary Alveoli | 1986 |
[Effect of an inhibitor of steroid hydroxylation on drug demethylation].
Topics: Aminopyrine; Animals; Depression, Chemical; Liver; Metyrapone; Microsomes; Mixed Function Oxygenases; Rats | 1967 |
Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Catalysis; Cytochrome P-450 Enzyme System; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Morphinans; Morphine; Oxidoreductases, N-Demethylating; Phenobarbital; Protein Binding; Rats | 1973 |
Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Animals; Binding Sites; Cytochrome P-450 Enzyme System; Electron Transport Complex IV; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Morphine; Oxidoreductases, N-Demethylating; Phenobarbital; Protein Binding; Rats | 1973 |
[On the effect of metyrapone on microsomal drug metabolism].
Topics: Acetanilides; Aminopyrine; Animals; Depression, Chemical; Glucosephosphate Dehydrogenase; Liver; Metyrapone; Mice; Microsomes; Mixed Function Oxygenases; NADP; Nitrobenzenes; Rats | 1967 |
Effects of metyrapone on liver microsomal drug oxidations.
Topics: Acetanilides; Aminopyrine; Animals; Depression, Chemical; Hexobarbital; In Vitro Techniques; Male; Metyrapone; Microsomes, Liver; Morphine; NADP; Phenobarbital; Rats; Sleep; Stimulation, Chemical; Trichloroethylene; Tyramine | 1969 |
Failure of various drugs to induce drug-metabolizing enzymes in extrahepatic tissues of the rat.
Topics: Adrenal Glands; Aminopyrine; Aniline Compounds; Animals; Brain; Chlorpromazine; Coumarins; Enzyme Induction; Female; Hexobarbital; Hydrochlorothiazide; Intestines; Kidney; Liver; Male; Methylcholanthrene; Metyrapone; Mixed Function Oxygenases; Organ Size; Oxidoreductases; Phenobarbital; Rats; Rats, Inbred Strains; Sex Factors | 1971 |
The binding of metyrapone to cytochrome P-450 and its inhibitory action on liver microsomal mixed-function oxidase reactions.
Topics: Acetanilides; Aminopyrine; Animals; Binding Sites; Codeine; Cytochromes; Hexobarbital; Metyrapone; Microsomes, Liver; Morphinans; Nitrophenols; Oxidation-Reduction; Rats; Spectrum Analysis | 1971 |
Inhibition of oxidative drug metabolism by metyrapone.
Topics: Acetanilides; Adrenal Glands; Aminopyrine; Animals; Biotransformation; Depression, Chemical; Liver; Metyrapone; Nitrophenols; Rats | 1968 |
Generation of low-level chemiluminescence during the metabolism of 1-naphthol by rat liver microsomes.
Topics: Aminopyrine; Animals; Dicumarol; In Vitro Techniques; Luminescent Measurements; Malondialdehyde; Metyrapone; Microsomes, Liver; Naphthols; Oxygen Consumption; Quinone Reductases; Rats | 1984 |
Involvement of radical species in the oxidation of aminopyrine and 4-aminoantipyrine by cumene hydroperoxide in rat liver microsomes.
Topics: Aminopyrine; Ampyrone; Animals; Antipyrine; Benzene Derivatives; Cytochrome P-450 Enzyme System; Free Radicals; In Vitro Techniques; Kinetics; Male; Metyrapone; Microsomes, Liver; Oxidation-Reduction; Peroxides; Rats | 1981 |
Drug metabolism and fetal toxicity: changes in fetal toxicity of aminopyrine by variation of drug metabolizing enzyme activity in mice.
Topics: Aminopyrine; Aminopyrine N-Demethylase; Aniline Hydroxylase; Animals; Cobalt; Female; Fetal Death; Male; Methylcholanthrene; Metyrapone; Mice; Mice, Inbred ICR; Pharmaceutical Preparations; Pregnancy; Proadifen | 1981 |
Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes.
Topics: Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Ascorbic Acid; Barbital; Buthionine Sulfoximine; Cells, Cultured; Chlorobutanol; Chromatography, High Pressure Liquid; Clotrimazole; Diamide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Galactosamine; Glucuronates; Glucuronic Acid; Hepatocytes; Imidazoles; Imidazolidines; Metyrapone; Models, Chemical; Preservatives, Pharmaceutical; Proadifen; Rats; Rats, Wistar; Resorcinols; Time Factors; Xenobiotics; Xylulose | 2003 |
Glucuronate, the precursor of vitamin C, is directly formed from UDP-glucuronate in liver.
Topics: Adenosine Triphosphate; Aminopyrine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Ascorbic Acid; Cell-Free System; Chlorobutanol; Enzyme Inhibitors; Glucuronates; Glucuronidase; Glucuronosyltransferase; Liver; Male; Metyrapone; Microsomes, Liver; Preservatives, Pharmaceutical; Rats; Rats, Wistar; Uridine Diphosphate Glucuronic Acid; Xenobiotics | 2006 |