aminopterin has been researched along with guanine in 15 studies
| Studies (aminopterin) | Trials (aminopterin) | Recent Studies (post-2010) (aminopterin) | Studies (guanine) | Trials (guanine) | Recent Studies (post-2010) (guanine) |
|---|---|---|---|---|---|
| 1,389 | 73 | 109 | 16,278 | 822 | 4,809 |
| Protein | Taxonomy | aminopterin (IC50) | guanine (IC50) |
|---|---|---|---|
| Purine nucleoside phosphorylase | Homo sapiens (human) | 5 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (66.67) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Irvin, AD; Stagg, DA | 1 |
| Kitos, P; Morrow, J; Parsons, M; Stocco, D | 1 |
| Benke, PJ; Hebert, A; Herrick, N | 1 |
| Evans, HJ; Gardiner, SE; Gormley, IP; Harris, H; Watson, B | 1 |
| Bigley, R; Hu, F; Pasztor, LM; Stankova, L | 1 |
| de Ruijter, CE; Simons, JW; van Zeeland, AA | 1 |
| D'Ari, L; Rabinowitz, JC; Samuel, CE | 1 |
| Benke, PJ; Herrick, N | 1 |
| Arakawa, T; Wada, Y | 1 |
| Takimoto, CH | 1 |
| CASPARI, E; MUTH, W; POHLEY, HJ | 1 |
| Campos, D; Diaz, A; Izbicka, E; Saunders, M; Steffen, R; Streeper, R; Wick, M | 1 |
| Adamson, PC; Norris, RE | 1 |
| Bertino, JR; Farooqi, IN; Kathari, YK; Tedeschi, PM | 1 |
1 review(s) available for aminopterin and guanine
| Article | Year |
|---|---|
Antifolates in clinical development.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1997 |
14 other study(ies) available for aminopterin and guanine
| Article | Year |
|---|---|
Theileria parva: purine and pyrimidine metabolism and the action of folate antagonists in parasitized bovine lymphoid cells.
Topics: Adenine; Aminopterin; Animals; Azaguanine; Cattle; Cells, Cultured; Culture Media; Eukaryota; Floxuridine; Folic Acid Antagonists; Guanine; Hypoxanthines; Lymphocytes; Methotrexate; Purines; Pyrimidine Nucleosides; Theileriasis; Thymidine; Uridine | 1977 |
Purine uptake by azaguanine-resistant Chinese hamster cells.
Topics: Amino Acids; Aminopterin; Azaguanine; Cell Line; Drug Resistance; Guanine; Hypoxanthine Phosphoribosyltransferase; Hypoxanthines; Inosine Nucleotides; Protein Biosynthesis; Uridine | 1976 |
Hypoxanthine-guanine phosphoribosyltransferase variant associated with accelerated purine synthesis.
Topics: Adolescent; Aminopterin; Azaguanine; Azaserine; Cells, Cultured; Culture Media; Erythrocytes; Fibroblasts; Guanine; Humans; Hydrogen-Ion Concentration; Hypoxanthines; Kinetics; Lesch-Nyhan Syndrome; Male; Mutation; Organophosphorus Compounds; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Temperature; Uric Acid | 1973 |
Reappearance of murine hypoxanthine guanine phosphoribosyl transferase activity in mouse A9 cells after attempted hybridisation with human cell lines.
Topics: Aminopterin; Animals; Cell Line; Cells, Cultured; Embryo, Mammalian; Fibroblasts; Genes; Glucosephosphate Dehydrogenase; Guanine; Humans; Hybrid Cells; Hybridization, Genetic; Hypoxanthines; Karyotyping; Leukemia, Lymphoid; Lung; Lymphocyte Activation; Lymphocytes; Mice; Pentosyltransferases; Phosphoglycerate Kinase; Sex Chromosomes; Thymidine | 1972 |
8-Azaguanine-resistant melanoma cells in vitro and in vivo.
Topics: Aminopterin; Animals; Azaguanine; Bromodeoxyuridine; Cell Division; Cell Fusion; Cell Line; Drug Resistance; Glycine; Guanine; Hybrid Cells; Hypoxanthines; Karyotyping; Melanoma; Mice; Mice, Inbred C57BL; Molecular Biology; Neoplasms, Experimental; Pentosyltransferases; Thymidine; Thymidine Kinase | 1974 |
The role of 8-azaguanine in the selection from human diploid cells of mutants deficient in hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT).
Topics: Aminopterin; Autoradiography; Azaguanine; Cell Line; Clone Cells; Culture Media; Drug Resistance; Fibroblasts; Guanine; Humans; Hypoxanthines; In Vitro Techniques; Lesch-Nyhan Syndrome; Male; Mutation; Penis; Pentosyltransferases; Probability; Thymidine; Tritium | 1974 |
Evidence against the folate-mediated formylation of formyl-accepting methionyl transfer ribonucleic acid in Streptococcus faecalis R.
Topics: Adenine; Aminopterin; Bacterial Proteins; Culture Media; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; Formates; Guanine; Methionine; Pyrimidines; RNA, Transfer; Serine; Thymine | 1970 |
Azaguanine-resistance as a manifestation of a new form of metabolic overproduction of uric acid.
Topics: Adenine; Adolescent; Aminopterin; Azaguanine; Blood Urea Nitrogen; Carbon Isotopes; Cell Line; Creatinine; Drug Resistance; Electrophoresis, Starch Gel; Erythrocytes; Fibroblasts; Gout; Guanine; Humans; Hypoxanthines; Lesch-Nyhan Syndrome; Male; Mercaptopurine; Pentosyltransferases; Purines; Uric Acid | 1972 |
Influence of aminopterin administration to dams upon single carbon transfer into purines of fetal brains.
Topics: Adenine; Aminopterin; Animals; Brain; Carbon Isotopes; Female; Fetus; Formates; Gestational Age; Guanine; Histidine; Injections, Intraperitoneal; Maternal-Fetal Exchange; Pregnancy; Purines; Rats; Serine | 1968 |
EFFECTS OF DNA BASE ANALOGUES ON THE SCALES OF THE WING OF EPHESTIA.
Topics: Aminopterin; Animals; Bromodeoxyuridine; DNA; Genetics; Guanine; Insecta; Mutation; Pharmacology; Purines; Radiation Genetics; Research; Thymidine; Wings, Animal | 1965 |
Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancers.
Topics: Aminopterin; Cell Line, Tumor; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Kinetics; Methotrexate; Neoplasms; Pemetrexed; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Xenograft Model Antitumor Assays | 2009 |
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias.
Topics: Aminopterin; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Jurkat Cells; Leukemia; Lymphoma; Methotrexate; Molecular Structure; Ornithine; Pemetrexed; Pterins | 2010 |
StatBite: FDA oncology drug product approvals in 2009.
Topics: Administration, Oral; Aminopterin; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Cetuximab; Depsipeptides; Drug Approval; Everolimus; Ferrosoferric Oxide; Glutamates; Guanine; Humans; Indazoles; Injections; Panitumumab; Pemetrexed; Pyrimidines; Sirolimus; Sulfonamides; United States; United States Food and Drug Administration | 2010 |
Leucovorin rescue allows effective high-dose pralatrexate treatment and an increase in therapeutic index in mesothelioma xenografts.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Female; Folic Acid Antagonists; Glutamates; Guanine; Humans; Leucovorin; Mesothelioma; Methotrexate; Mice, Nude; Pemetrexed; Time Factors; Tumor Burden; Vitamin B Complex; Xenograft Model Antitumor Assays | 2014 |