Page last updated: 2024-09-05

aminopterin and gemcitabine

aminopterin has been researched along with gemcitabine in 11 studies

Compound Research Comparison

Studies
(aminopterin)
Trials
(aminopterin)
Recent Studies (post-2010)
(aminopterin)
Studies
(gemcitabine)
Trials
(gemcitabine)
Recent Studies (post-2010) (gemcitabine)
1,3897310912,5233,2086,923

Protein Interaction Comparison

ProteinTaxonomyaminopterin (IC50)gemcitabine (IC50)
Chain A, DEOXYNUCLEOSIDE KINASEDrosophila melanogaster (fruit fly)0.76
Equilibrative nucleoside transporter 1Homo sapiens (human)0.19

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (36.36)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Klastersky, J1
Grant, SC; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR1
Edelman, MJ; Gandara, DR1
Armand, JP1
Gardner, J; Gonen, M; Heaney, M; O'Connor, OA; Sirotnak, F; Smith, EA; Teruya-Feldstein, J; Toner, LE; Vrhovac, R1
O'Leary, HM; Savage, KJ1
Mangone, M; Marchi, E; O'Connor, OA; Zullo, K1
Duvic, M1
Beltran, BE; Conlon, K; Cook, L; Dwyer, K; Feldman, T; Fields, PA; Gonsky, J; Hermine, O; Horwitz, SM; Humphrey, J; Kurman, M; Leoni, M; Moriya, J; Pereira, J; Phillips, AA; Ramos, JC; Sawas, A; Taylor, GP; Wandroo, F1
Desai, N; Goff, HW; Rizvi, S; Stewart, JR; Zhu, H1
Kaur, H; Lee, YS; Ong, SY; Phipps, C; Tan, L1

Reviews

6 review(s) available for aminopterin and gemcitabine

ArticleYear
New drug for therapy of non-small cell lung cancer.
    Lung cancer (Amsterdam, Netherlands), 1994, Volume: 11 Suppl 3

    Topics: Aminopterin; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine

1994
New chemotherapeutic agents for non-small cell lung cancer.
    Chest, 1995, Volume: 107, Issue:6 Suppl

    Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Quinoxalines; Sulfanilamides; Taxoids; Topotecan; Vinblastine; Vinorelbine

1995
Promising new agents in the treatment of non-small cell lung cancer.
    Cancer chemotherapy and pharmacology, 1996, Volume: 37, Issue:5

    Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine

1996
New anticancer drugs in Europe.
    Gan to kagaku ryoho. Cancer & chemotherapy, 1997, Volume: 24 Suppl 1

    Topics: Aminopterin; Anthraquinones; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aziridines; Bridged-Ring Compounds; Bryostatins; Camptothecin; Dacarbazine; Deoxycytidine; Distamycins; Doxorubicin; Europe; Gemcitabine; Humans; Indolequinones; Indoles; Irinotecan; Lactones; Macrolides; Nitrogen Mustard Compounds; Nitrosourea Compounds; Pyrazoles; Quinazolines; Taxoids; Temozolomide; Thiophenes; Vinca Alkaloids

1997
Novel therapies in peripheral T-cell lymphomas.
    Current oncology reports, 2008, Volume: 10, Issue:5

    Topics: Alemtuzumab; Aminopterin; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Deoxycytidine; Diphtheria Toxin; Enzyme Inhibitors; Gemcitabine; Humans; Immunotherapy; Interleukin-2; Lymphoma, T-Cell, Peripheral; Medical Oncology; Prognosis; Recombinant Fusion Proteins; Treatment Outcome

2008
Alemtuzumab is an effective third-line treatment versus single-agent gemcitabine or pralatrexate for refractory Sézary syndrome: a systematic review.
    European journal of dermatology : EJD, 2018, Dec-01, Volume: 28, Issue:6

    Topics: Alemtuzumab; Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents, Immunological; Deoxycytidine; Folic Acid Antagonists; Gemcitabine; Humans; Mycosis Fungoides; Retreatment; Sezary Syndrome; Skin Neoplasms

2018

Trials

2 trial(s) available for aminopterin and gemcitabine

ArticleYear
Pralatrexate pharmacology and clinical development.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2013, Dec-15, Volume: 19, Issue:24

    Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Boronic Acids; Bortezomib; Deoxycytidine; Depsipeptides; Disease-Free Survival; Drug Approval; Drug Synergism; Gemcitabine; Humans; Lymphoma, T-Cell; Male; Pyrazines; Treatment Outcome; United States; United States Food and Drug Administration

2013
Mogamulizumab
    Haematologica, 2019, Volume: 104, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cytarabine; Deoxycytidine; Dexamethasone; Drug Resistance, Neoplasm; Female; Follow-Up Studies; Gemcitabine; Humans; International Agencies; Leukemia-Lymphoma, Adult T-Cell; Male; Middle Aged; Neoplasm Recurrence, Local; Oxaliplatin; Prognosis; Retrospective Studies; Salvage Therapy; Survival Rate; Young Adult

2019

Other Studies

3 other study(ies) available for aminopterin and gemcitabine

ArticleYear
The schedule-dependent effects of the novel antifolate pralatrexate and gemcitabine are superior to methotrexate and cytarabine in models of human non-Hodgkin's lymphoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2006, Feb-01, Volume: 12, Issue:3 Pt 1

    Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Cycle; Cytarabine; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Evaluation, Preclinical; Gemcitabine; Humans; In Vitro Techniques; Lymphoma, Non-Hodgkin; Methotrexate; Mice; Mice, SCID; Time Factors; Xenograft Model Antitumor Assays

2006
Choosing a systemic treatment for advanced stage cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome.
    Hematology. American Society of Hematology. Education Program, 2015, Volume: 2015

    Topics: Alemtuzumab; Aminopterin; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bortezomib; Clinical Trials as Topic; Deoxycytidine; Depsipeptides; Diphtheria Toxin; Disease Progression; Doxorubicin; Electrons; Gemcitabine; Humans; Hydroxamic Acids; Immunotherapy; Incidence; Interleukin-2; Lenalidomide; Lymphoma, T-Cell; Mycosis Fungoides; Pentostatin; Photopheresis; Polyethylene Glycols; Randomized Controlled Trials as Topic; Recombinant Fusion Proteins; Retinoids; Sezary Syndrome; Stem Cell Transplantation; Thalidomide; United States; Vorinostat

2015
Pralatrexate Induces Long-Term Remission in Relapsed Subcutaneous Panniculitis-Like T-Cell Lymphoma.
    Annals of the Academy of Medicine, Singapore, 2019, Volume: 48, Issue:9

    Topics: Adult; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cisplatin; Cyclophosphamide; Deoxycytidine; Dexamethasone; Doxorubicin; Folic Acid Antagonists; Gemcitabine; Humans; Lymphohistiocytosis, Hemophagocytic; Lymphoma, T-Cell, Peripheral; Male; Neoplasm Recurrence, Local; Panniculitis; Prednisone; Remission Induction; Subcutaneous Fat, Abdominal; Vincristine

2019