Page last updated: 2024-08-21

aminopenicillanic acid and penicillanic acid

aminopenicillanic acid has been researched along with penicillanic acid in 180 studies

Research

Studies (180)

Timeframe	Studies, this research(%)	All Research%
pre-1990	75 (41.67)	18.7374
1990's	26 (14.44)	18.2507
2000's	45 (25.00)	29.6817
2010's	33 (18.33)	24.3611
2020's	1 (0.56)	2.80

Authors

Authors	Studies
Forsman, U; Karlberg, B	1
Chojnowski, W; Gralewicz, J; Jastalska, D; Morris-Rostkowska, W; Zapaśnik, M	1
Di Bitetto, M; Mangia, A; Silingardi, S	1
Kornfeld, JM	1
Ishiguro, EE; Iwaya, M; Turley, W	1
Bartoshevich, IuE; Lur'e, LM; Suvorova, MV; Tikhonova, OV	1
Chang, HN; Lee, CY; Lee, YH	1
Ambekar, GR; Bhatnagar, S; Gadre, RA; Koilpillai, L; Kumar, KK; Ponrathnam, S; Raman, RC; Shewale, JG	1
Erarslan, A; Güray, A	1
Barenschee, T; Scheper, T; Schügerl, K	1
Nayler, JH	1
Luengo, JM; Martín-Villacorta, J; Reglero, A	2
Dunbar, B; Horrocks, AJ; Lindsay, CD; Slade, A; Virden, R	1
Fernández-Cañón, JM; Ferrero, MA; Luengo, JM; Martín-Villacorta, J; Reglero, A	1
Luengo, JM; Martín-Villacorta, J; Martínez-Blanco, H; Reglero, A	1
Bryan, LE; Godfrey, AJ	1
Forsman, M; Häggström, B; Jaurin, B; Lindgren, L	1
Alvarez, E; Barredo, JL; Cantoral, JM; Díez, B; Martín, JF	1
Goldberg, RN; Tewari, YB	1
Rolinson, GN	3
Karlsen, LG; Møllgaard, H	1
Yabu, K	3
Luengo, JM	1
Bartoshevich, IuE; Navashin, SM; Nys, PS; Shviadas, VIu	1
Briese, T; Ellerbrok, H; Hakenbeck, R	1
Iriso, JL; López-Nieto, MJ; Luengo, JM	1
Haginaka, J; Wakai, J	1
Fong, GW; Johnson, RN; Kho, BT; Martin, DT	1
Koeda, T; Yoshida, M	1
Haufler, U; Kasche, V; Riechmann, L	1
Baker, WL	2
Haufler, U; Kasche, V; Zöllner, R	1
Cieślak, J; Kazimierczak, J; Kotulowa, W; Mikołajczyk, J	1
Wojskowicz, J	1
Fukagawa, Y; Ishikura, T; Takei, T	1
Chacko, E; Sheehan, JC; Shibahara, S	1
Baker, WL; Blake, BD	1
Selwyn, S	1
Frère, JM; Ghuysen, JM; Kelly, JA; Klein, D	1
Galunsky, B; Kasche, V	1
Gunda, TE; Punyiczki, M	1
Georgiev, D; Neĭchev, Kh; Shirova, L; Slavcheva, E; Toshkov, A	1
Shirova, L; Toshkov, A	1
König, HB; Metzger, KG; Offe, HA; Schröck, W	1
Kopecek, J; Solovskij, MV; Ulbrich, K	1
Day, RA; Heckler, TG	1
Barron, RP; Benson, WR; Ohashi, M	1
Balabanova, EL; Baru, RV; Lapchinskaia, AV; Sergeeva, EI; Zel'tser, IZ	1
Flegel, TW; Meevootisom, V; Prachaktam, R; Somsuk, P	1
Gestrelius, S; Møllgaard, H; Nielsen, BH	1
Sosnovskaya, IN; Yatsimirskaya, NT; Yatsimirsky, AK	1
Bartoshevich, IuE; Nys, PS	1
Matsumoto, K	1
Aguiar, MR; Gemal, AL; Menezes, SM; San Gil, RA	1
Casy, AF; Lipczynski, A	1
Frère, JM; Galleni, M; Jamin, M; Joris, B; Lakaye, B; Lepage, S; Thamm, I	1
Aplin, RT; Baldwin, JE; Roach, PL; Robinson, CV; Schofield, CJ	1
Demonty, J	1
Ma, TX; Zhang, LR	1
Abraham, EP; Whiteman, PA	1
Lucas, L; Schügerl, K; Yang, ZF	1
Bruns, O; Bruns, W; Pulverer, G	1
Cabral, JM; Fonseca, LP	1
Lowenstein, CJ; McMillan, A; Ocampo, CJ; Saura, M; Zaragoza, C	1
Chou, CP; Kuo, BY; Lin, WJ; Wang, WC; Yu, CC	1
Fernandez-Lafuente, R; Giordano, RL; Gonçalves, LR; Guisán, JM	1
Kaloyanov, N; Stoyanova, R	1
Prabhu, KS; Ramadoss, CS	1
Acebal, C; Arroyo, M; Castillón, MP; de La Mata, I; Torres-Bacete, J; Torres-Guzmán, R	1
Svedas, VK; Youshko, MI	1
de Vroom, E; Sheldon, RA; Svedas, VK; van Langen, LM; van Rantwijk, F; Youshko, MI	2
Marestani, Z; Mrestani, Y; Neubert, RH	1
Alonso, J; Fernández-Lafuente, R; Fernández-Lorente, G; García-López, JL; Guisan, JM; Hernández-Jústiz, O; Mateo, C; Moreno, MA; Terreni, M	1
Beyer, M; Jakobsen, M; Nielsen, J; Noorman, H; Robin, J	1
Buchberger, W; Haddad, PR; Hilder, EF; Klampfl, CW	1
Diender, MB; Heijnen, JJ; Ras, C; Straathof, AJ; van der Does, T	1
Adrangui, M; Ghassempour, A; Nasiri-Aghdam, M; Salehpour, P; Vaezi, F	1
Alkema, WB; de Vries, E; Janssen, DB; Prins, AK	1
Fernandez-Lafuente, R; Giordano, RC; Giordano, RL; Gonçalves, LR; Guisan, JM; Sousa, R	1
Chilov, GG; Shcherbakova, TA; Svedas, VK; Youshko, MI	1
Acebal, C; Arroyo, M; Castillón, MP; de la Mata, I	1
Du, JY; Zhang, MJ; Zhao, JM	1
Balestrini, AA; Beric, V; Kibbler, CC; Quick, A; Stone, SP	1
Fernandez-Lafuente, R; Giordano, RC; Giordano, RL; Gonçalves, LR; Guisan, JM	1
Barboza, M; Giordano, Rde L; Vieira, MF	1
Bukhanov, AL; Svedas, VK; Youshko, MI	1
Chmelíková, R; Hasal, P; Zadrazil, A	1
Alkema, WB; de Vries, E; Floris, R; Janssen, DB	1
BATCHELOR, FR; DOYLE, FP; NAYLER, JH; ROLINSON, GN	1
BALLIO, A; CHAIN, EB; DENTICE DI ACCADIA, F; MAURI, M; RAUER, K; SCHLESINGER, MJ; SCHLESINGER, S	1
ENGLISH, AR; HUANT, HT; SOBIN, BA	1
HUGO, WB; RUSSELL, AD	1
KAMEDA, Y; KIMURA, Y; OMORI, T; TOYOURA, E	1
BATCHELOR, FR; WOOD, JC	1
FALLOWFIELD, TL	1
HARRISON, PM; STEWART, GT	1
HUANG, HT; SETO, TA; SHULL, GM	1
SZTARICSKAI, F; URI, J	1
CHENEY, LC; CRAST, LB; GOUREVITCH, A; LEIN, J; MINOR, WF; PERRON, YG	1
KULHANEK, M; TADRA, M	1
BEKESI, I; URI, J; VALU, G	1
CIGNARELLA, G; CRISTIANI, GF; PIFFERI, G; TESTA, E; TIMBAL, MT	1
WALTON, RB	1
JAGO, M	1
WATSON, KC	1
DAY, RA; SHAH, R; YIP, LC	1
ROBINSON, OP	1
CENEY, LC; CRAST, LB; ESSERY, JM; FRASER, RR; GODFREY, JC; HOLDREGE, CT; MINOR, WF; NEUBERT, ME; PARTYKA, RA; PERRON, YG	1
CIGNARELLA, G; FUERESZ, S; MAFFII, G; PIFFERI, G; SCHIATTI, P; TESTA, E; TIMBAL, MT	1
BOMSTEIN, J; EVANS, WG	1
BRANDRISS, MW; SMITH, JW; STEINMAN, HG	1
BATCHELOR, FR; BUTTERWORTH, D; CAMERON-WOOD, J; CHAIN, EB; COLE, M; EUSTACE, GC; HART, MV; RICHARDS, M; ROLINSON, GN	1
BATCHELOR, FR; CAMERON-WOOD, J; CHAIN, EB; ROLINSON, GN	1
BATCHELOR, FR; CHAIN, EB; HARDY, TL; MANSFORD, KR; ROLINSON, GN	1
BATCHELOR, FR; CHAIN, EB; RICHARDS, M; ROLINSON, GN	1
BATCHELOR, FR; CHAIN, EB; ROLINSON, GN	1
COLE, M; ROLINSON, GN	1
Boosten, WH; Bukhanov, AL; Moody, HM; Svedas, VK; Youshko, MI	1
Cabral, JM; Cao, XJ; Fonseca, LJ; Marcos, JC; Wu, XY	1
Gabor, EM; Janssen, DB	1
Helm, RF; Jervis, J; Joardar, V; Potts, M; Scherer, S; Smith, SC; Warren, A; Wright, DJ	1
Biron, F; Depagne, C; Guerin, JC; Louerat, C; Nesme, P	1
Geddes, AM; Rolinson, GN	1
Gunasekaran, P; Rajendhran, J	1
García-Estrada, C; Lamas-Maceiras, M; Martín, JF; Vaca, I	1
Hall, AJ; Moreno-Bondi, MC; Orellana, G; Sellergren, B; Urraca, JL	1
Kóczián, K; Kökösi, J; Noszál, B; Szakács, Z	1
Ben Salem, A; Corvis, Y; de Vains, JB; Korchowiec, B; Korchowiec, J; Rogalska, E	1
Cao, XJ; Chu, J; Jin, KM; Ma, L; Su, J; Zhang, SL; Zhuang, YP	1
Chan, HW; Chan, KC; Chan, PH; Chung, WH; Lai, TS; Leung, YC; Ma, DL; Siu, FM; So, PK; Tsang, CW; Wong, KY; Yiu, KF; Zhao, Y	1
Brace, JR; Karagulle Kendi, AT; Kieffer, SA; Krenzel, C; Norberg, SK; Ott, FW	1
Guo, C; Jiang, Y; Liu, H; Mahmood, I; Xia, H	1
Chen, W; Cooper, WJ; Greaves, J; Miller, GE; Song, W	1
Bergeron, LM; Clark, DS; Gomez, L; Shis, DL	1
Ali, SS; Arshad, R; Farooq, S	2
Harris, DA; Powers, ME; Romesberg, FE	1
Cox, LA; Mathers, JJ; Popken, DA	1
Cruz, AJ; Giordano, RC; Nucci, ER	1
Aguilar-González, CN; Ilyina, A; Martínez-Hernández, JL; Mata-Gómez, MA	1
Kurt, M; Ramalingam, M; Sebastian, S; Sethuraman, V; Sundaraganesan, N; Swaminathan, J	1
Fang, SG; Liu, RJ; Qiang, T; Xu, XM; Zhang, YW	1
Liu, RJ; Xu, XM; Zhang, YW	1
Luo, G; Wang, Y; Zhao, J; Zhu, S	1
Chen, Z; Li, X; Ren, N; Shi, Y; Wang, A; Wang, H	1
Barbaud, A; Schmutz, JL; Trechot, P	1
Das, S; Dolui, AK	1
Kurochkina, VB; Satarova, JE; Sklyarenko, AV; Yarotsky, SV	1
Guddat, LW; Hussein, WM; McGeary, RP; Schenk, G; Ul Islam, N	1
Gao, L; Qi, K; Shen, H; Tan, H; Tian, C	1
Crea, F; Cucinotta, D; De Stefano, C; Milea, D; Sammartano, S; Vianelli, G	1
de Oliveira, KN; Kowalski, K; Ott, I; Rajnisz, A; Skiba, J; Solecka, J	1
Ashar, TK; Bečka, S; Datla, A; Dobišová, M; Grulich, M; Kyslík, P; Marešová, H; Maršálek, J; Palyzová, A; Plačková, M; Plháčková, K; Štěpánek, V; Valešová, R; Vyasarayani, RW	1
Buth, G; Fabbiani, FP; Saouane, S	1
Pipalova, R; Slezak, R; Vlcek, J	1
Koo, YM; Mai, NL	1
Gallo, RL; Haste, NM; Kristian, SA; Meharena, HS; Nizet, V; Olson, J; Pence, MA	1
Hannisdal, A; Kahlmeter, G; Kristiansen, BE; Lia, A; Matuschek, E; Skaare, D; Tveten, Y	1
Deshmukh, AT; Heijnen, JJ; Maleki Seifar, R; van Gulik, WM; Verheijen, PJT	1
De Rosa, M; Palma, G; Saturnino, C; Soriente, A; Vigliotta, G	1
Cao, X; Lu, A; Su, M; Sun, H; Wang, J; Zhao, Y	1
Buchholz, K	1
Avinash, VS; Chauhan, PD; Gaikwad, S; Pundle, A	1
Abdelaleem, EA; Hussein, EA; Naguib, IA; Zaazaa, HE	1
Ashish, EY; Debnath, M; Nupur, N	1
Döndaş, HA; Gizir, AM; Yabalak, E	1
Jia, Y; Jiang, X; Ran, B; Shao, H; Wang, L; Yang, G; Yang, J; Yang, X; Zhang, L	1
Abdelrahman, MM; Elsayed, MA; Naguib, IA; Zaazaa, HA	1
Hasal, P; Přibyl, M; Romanov, A; Slouka, Z; Vobecká, L	1
Cao, F; Huang, B; Xu, G; Zhao, Q; Zhou, J	1
Jiang, Z; Shi, J; Sun, Y; Zhang, S; Zhao, J	1
Přibyl, M; Romanov, A; Slouka, Z	1

Reviews

6 review(s) available for aminopenicillanic acid and penicillanic acid

Article	Year
The Garrod lecture. The influence of 6-aminopenicillanic acid on antibiotic development. The Journal of antimicrobial chemotherapy, 1988, Volume: 22, Issue:1 Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Penicillanic Acid	1988
[Role of biocatalysis in the creation and improvement of production of beta-lactam antibiotics in Russia]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1994, Volume: 39, Issue:8 Topics: Anti-Bacterial Agents; Catalysis; Cephalosporins; Enzymes, Immobilized; Penicillanic Acid; Russia; Technology, Pharmaceutical	1994
Production of 6-APA, 7-ACA, and 7-ADCA by immobilized penicillin and cephalosporin amidases. Bioprocess technology, 1993, Volume: 16 Topics: Bacillus megaterium; Cephalosporinase; Cephalosporins; Enzymes, Immobilized; Industrial Microbiology; Penicillanic Acid; Penicillin Amidase	1993
Biotechnological applications of penicillin acylases: state-of-the-art. Applied microbiology and biotechnology, 2003, Volume: 60, Issue:5 Topics: Anti-Bacterial Agents; Escherichia coli; Gene Expression Regulation, Bacterial; Industrial Microbiology; Models, Molecular; Penicillanic Acid; Penicillin Amidase; Technology, Pharmaceutical	2003
The 50th anniversary of the discovery of 6-aminopenicillanic acid (6-APA). International journal of antimicrobial agents, 2007, Volume: 29, Issue:1 Topics: Anti-Bacterial Agents; Bacterial Infections; beta-Lactamase Inhibitors; beta-Lactamases; beta-Lactams; Cephalosporins; Humans; Hydrolysis; Penicillanic Acid; Penicillins; Thienamycins	2007
A breakthrough in enzyme technology to fight penicillin resistance-industrial application of penicillin amidase. Applied microbiology and biotechnology, 2016, Volume: 100, Issue:9 Topics: Drug Discovery; Enzymes, Immobilized; Germany; Hydrolysis; London; Penicillanic Acid; Penicillin Amidase; Penicillins; Technology, Pharmaceutical	2016

Other Studies

174 other study(ies) available for aminopenicillanic acid and penicillanic acid

Article	Year
Titration of 6-aminopenicillanic acid with mercury (II) solution. Analytica chimica acta, 1976, Volume: 86, Issue:1 Topics: Hydrogen-Ion Concentration; Indicators and Reagents; Mercury; Methods; Penicillanic Acid	1976
[Biological properties of some new antibacterial antibiotics. I. Activities of some derivatives of 6-aminopenicillanic acid (6-AP) and 7-aminocephallosporanic acid (7-AC)]. Acta poloniae pharmaceutica, 1975, Volume: 32, Issue:6 Topics: Bacteria; Cephalosporins; Drug Resistance, Microbial; Penicillanic Acid	1975
GLC determination of 6-aminopenicillanic acid and 7-amino-3-methyl-delta3-cephem-4-carboxylic acid. Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:12 Topics: Cephalosporins; Chromatography, Gas; Penicillanic Acid; Trimethylsilyl Compounds	1977
A new colorimetric method for the determination of 6-aminopenicillanic acid. Analytical biochemistry, 1978, Volume: 86, Issue:1 Topics: Colorimetry; Drug Stability; Osmolar Concentration; Penicillanic Acid; Penicillinase; Time Factors	1978
Temperature-sensitive 6-aminopenicillanic acid-resistant mutants of Escherichia coli. Antimicrobial agents and chemotherapy, 1979, Volume: 16, Issue:6 Topics: Drug Resistance, Microbial; Escherichia coli; Mutation; Penicillanic Acid; Protein Binding; Temperature; Time Factors; Transduction, Genetic	1979
[Effect of penicillin precursors on antibiotic biosynthesis in various strains]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic], 1992, Volume: 37, Issue:1 Topics: Penicillanic Acid; Penicillin G; Penicillin V; Penicillins; Penicillium chrysogenum; Prodrugs; Species Specificity	1992
Continuous production of 6-APA in an aqueous two-phase system. Annals of the New York Academy of Sciences, 1992, Nov-30, Volume: 672 Topics: Enzymes, Immobilized; In Vitro Techniques; Kinetics; Penicillanic Acid; Penicillin Amidase; Penicillin G; Recombinant Proteins; Solubility; Solvents	1992
Immobilization of penicillin G acylase on methacrylate polymers. Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986), 1990, Volume: 49, Issue:2 Topics: Cation Exchange Resins; Cross-Linking Reagents; Enzymes, Immobilized; Hydrogen-Ion Concentration; Kerosene; Membranes, Artificial; Methacrylates; Paraffin; Penicillanic Acid; Penicillin Amidase; Penicillin G; Polymers	1990
Kinetic investigation of penicillin G acylase from a mutant strain of Escherichia coli ATCC 11105 immobilized on oxirane-acrylic beads. Journal of chemical technology and biotechnology (Oxford, Oxfordshire : 1986), 1991, Volume: 51, Issue:2 Topics: Acrylates; Enzyme Stability; Enzymes, Immobilized; Escherichia coli; Ethylene Oxide; Hydrogen-Ion Concentration; Kinetics; Mutation; Penicillanic Acid; Penicillin Amidase; Penicillin G; Thermodynamics	1991
An integrated process for the production and biotransformation of penicillin. Journal of biotechnology, 1992, Volume: 26, Issue:2-3 Topics: Ampicillin; Biotransformation; Culture Media; Enzymes, Immobilized; Membranes, Artificial; Penicillanic Acid; Penicillins; Penicillium chrysogenum; Permeability	1992
Early discoveries in the penicillin series. Trends in biochemical sciences, 1991, Volume: 16, Issue:5 Topics: History, 20th Century; Penicillanic Acid; Penicillins	1991
Acyl-CoA: 6-APA acyltransferase from Penicillium chrysogenum studies on its hydrolytic activity. The Journal of antibiotics, 1991, Volume: 44, Issue:1 Topics: Acyl Coenzyme A; Acyltransferases; Hydrogen-Ion Concentration; Hydrolysis; Penicillanic Acid; Penicillin-Binding Proteins; Penicillium chrysogenum; Substrate Specificity; Temperature	1991
Site-directed chemical conversion of serine to cysteine in penicillin acylase from Escherichia coli ATCC 11105. Effect on conformation and catalytic activity. European journal of biochemistry, 1991, Apr-10, Volume: 197, Issue:1 Topics: Amino Acid Sequence; Circular Dichroism; Cysteine; Escherichia coli; Hydrogen-Ion Concentration; Kinetics; Molecular Sequence Data; Penicillanic Acid; Penicillin Amidase; Phenylmethylsulfonyl Fluoride; Protein Conformation; Pyridines; Serine; Sulfur Radioisotopes	1991
Biosynthesis of benzylpenicillin (G), phenoxymethylpenicillin (V) and octanoylpenicillin (K) from glutathione S-derivatives. The Journal of antibiotics, 1990, Volume: 43, Issue:6 Topics: Acyltransferases; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Glutathione; Micrococcus; Penicillanic Acid; Penicillin G; Penicillin V; Penicillin-Binding Proteins; Penicillins; Penicillium; Penicillium chrysogenum	1990
Design of an enzymatic hybrid system: a useful strategy for the biosynthesis of benzylpenicillin in vitro. FEMS microbiology letters, 1990, Volume: 60, Issue:1-2 Topics: Acyltransferases; Chromatography, High Pressure Liquid; Coenzyme A; Coenzyme A Ligases; Hydrogen-Ion Concentration; Kinetics; Oxidoreductases; Penicillanic Acid; Penicillin G; Penicillin-Binding Proteins; Penicillium chrysogenum; Phenylacetates; Pseudomonas; Temperature	1990
IV. Acyl-CoA: 6-APA acyltransferase of Penicillium chrysogenum: studies on substrate specificity using phenylacetyl-CoA variants. The Journal of antibiotics, 1989, Volume: 42, Issue:10 Topics: Acetyl Coenzyme A; Acyl Coenzyme A; Acyltransferases; Penicillanic Acid; Penicillin-Binding Proteins; Penicillium; Penicillium chrysogenum; Structure-Activity Relationship; Substrate Specificity	1989
Cell surface changes in Pseudomonas aeruginosa PAO4069 in response to treatment with 6-aminopenicillanic acid. Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:9 Topics: beta-Lactamases; Chemical Phenomena; Chemistry, Physical; Chloramphenicol; Chromosomes, Bacterial; Enzyme Induction; Immunoblotting; Lipopolysaccharides; Microbial Sensitivity Tests; Microscopy, Electron; Penicillanic Acid; Pseudomonas aeruginosa; Time Factors	1989
Transcriptional induction of Streptomyces cacaoi beta-lactamase by a beta-lactam compound. Molecular microbiology, 1989, Volume: 3, Issue:10 Topics: Amino Acid Sequence; Base Sequence; beta-Lactamases; Blotting, Northern; Gene Expression Regulation; Molecular Sequence Data; Penicillanic Acid; Streptomyces; Transcription, Genetic	1989
Purification to homogeneity and characterization of acyl coenzyme A:6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum. Antimicrobial agents and chemotherapy, 1987, Volume: 31, Issue:11 Topics: Acyltransferases; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Isoelectric Focusing; Molecular Weight; Penicillanic Acid; Penicillin G; Penicillin-Binding Proteins; Penicillium; Penicillium chrysogenum; Substrate Specificity; Temperature	1987
Thermodynamics of the conversion of penicillin G to phenylacetic acid and 6-aminopenicillanic acid. Biophysical chemistry, 1988, Volume: 29, Issue:3 Topics: Hydrogen-Ion Concentration; Kinetics; Penicillanic Acid; Penicillin G; Phenylacetates; Thermodynamics	1988
6-APA production in a pilot plant with an immobilized pen V acylase (SEMACYLASE). Annals of the New York Academy of Sciences, 1988, Volume: 542 Topics: Amidohydrolases; Biomedical Engineering; Enzymes, Immobilized; Kinetics; Penicillanic Acid; Penicillin Amidase	1988
Conversion of Staphylococcus aureus cells to stable L-forms in a liquid growth medium. Microbiology and immunology, 1985, Volume: 29, Issue:2 Topics: Culture Media; L Forms; Lysostaphin; Penicillanic Acid; Staphylococcus aureus	1985
Precipitation of phenyl and phenoxypenicillin from solutions using ammonium sulfate. Analytical biochemistry, 1985, Volume: 149, Issue:2 Topics: Ammonium Sulfate; Anti-Bacterial Agents; Buffers; Chemical Precipitation; Culture Media; Penicillanic Acid; Penicillin G; Penicillin V; Solubility; Solutions	1985
[Status and prospects in the use of biocatalysis in the synthesis of beta-lactam antibiotics]. Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, 1986, Volume: 31, Issue:2 Topics: Anti-Bacterial Agents; Catalysis; Chemical Phenomena; Chemistry; Enzymes, Immobilized; Penicillanic Acid; Penicillin Amidase	1986
Antibodies against the benzylpenicilloyl moiety as a probe for penicillin-binding proteins. European journal of biochemistry, 1986, May-15, Volume: 157, Issue:1 Topics: Animals; Antibodies; Bacillus subtilis; Bacterial Proteins; Carboxypeptidases; Carrier Proteins; Cephalosporins; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Hexosyltransferases; Immunosorbent Techniques; Methods; Muramoylpentapeptide Carboxypeptidase; Penicillanic Acid; Penicillin G; Penicillin-Binding Proteins; Peptidyl Transferases; Rabbits; Streptococcus pneumoniae	1986
Massive induction of Staphylococcus aureus unstable L-forms in a liquid medium. Microbiology and immunology, 1986, Volume: 30, Issue:3 Topics: Culture Media; Glycoside Hydrolases; Kinetics; L Forms; Penicillanic Acid; Staphylococcus aureus; Streptomyces	1986
Effect of nalidixic acid on the conversion of Staphylococcus aureus cells to L-forms in a liquid medium with 6-aminopenicillanic acid and lysozyme. Microbiology and immunology, 1986, Volume: 30, Issue:8 Topics: Culture Media; DNA Replication; Drug Synergism; L Forms; Muramidase; Nalidixic Acid; Penicillanic Acid; Staphylococcus aureus	1986
Direct evaluation of phenylacetyl-CoA: 6-aminopenicillanic acid acyltransferase of Penicillium chrysogenum by bioassay. The Journal of antibiotics, 1986, Volume: 39, Issue:11 Topics: Acetyl Coenzyme A; Acyltransferases; Biological Assay; Dithiothreitol; Kinetics; Microbial Sensitivity Tests; Micrococcus; Penicillanic Acid; Penicillin G; Penicillin-Binding Proteins; Penicillium; Penicillium chrysogenum	1986
High-performance liquid chromatographic determination of 6-aminopenicillanic acid by postcolumn alkaline degradation. Analytical biochemistry, 1986, Volume: 158, Issue:1 Topics: Amino Acids; Chromatography, High Pressure Liquid; Humans; Penicillanic Acid; Sodium Hydroxide; Spectrophotometry, Ultraviolet	1986
Determination of degradation products and impurities of amoxicillin capsules using ternary gradient elution high-performance liquid chromatography. Journal of chromatography, 1984, Aug-31, Volume: 298, Issue:3 Topics: Amoxicillin; Capsules; Chromatography, High Pressure Liquid; Glycine; Penicillanic Acid; Spectrophotometry, Ultraviolet	1984
Effects of aminobenzyl penicillin (AB-PC), methylchlorophenyl isoxazolyl penicillin (MCI-PC) and 6-aminopenicillanic acid (6-APA) on the contractile response of guinea-pig urinary bladder. Nihon Heikatsukin Gakkai zasshi, 1984, Volume: 20, Issue:1 Topics: Acetylcholine; Ampicillin; Animals; Cloxacillin; Electric Stimulation; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Penicillanic Acid; Urinary Bladder	1984
Kinetically controlled semisynthesis of beta-lactam antibiotics and peptides. Annals of the New York Academy of Sciences, 1984, Volume: 434 Topics: Amidohydrolases; Ampicillin; Anti-Bacterial Agents; Enzymes, Immobilized; Escherichia coli; Kinetics; Penicillanic Acid; Penicillin Amidase; Peptide Biosynthesis	1984
A sensitive procedure for screening microorganisms for the presence of penicillin amidase. Australian journal of biological sciences, 1984, Volume: 37, Issue:4 Topics: Amidohydrolases; Ampicillin; Bacteria; Fluorescamine; Methods; Penicillanic Acid; Penicillin Amidase; Penicillin G; Phenylacetates	1984
Kinetic studies on the mechanism of the penicillin amidase-catalysed synthesis of ampicillin and benzylpenicillin. Hoppe-Seyler's Zeitschrift fur physiologische Chemie, 1984, Volume: 365, Issue:12 Topics: Amidohydrolases; Ampicillin; Escherichia coli; Isoelectric Focusing; Kinetics; Osmolar Concentration; Penicillanic Acid; Penicillin Amidase; Penicillin G	1984
[Beta-lactamase inhibitors. II. Synthesis and biological properties of 6-sulfonylaminopenicillanic acids]. Acta poloniae pharmaceutica, 1984, Volume: 41, Issue:6 Topics: beta-Lactamase Inhibitors; Chemical Phenomena; Chemistry; Escherichia coli; In Vitro Techniques; Penicillanic Acid; Proteus mirabilis; Staphylococcus aureus	1984
Regulation of penicillin amidase activity in Escherichia coli. Acta microbiologica Polonica, 1981, Volume: 30, Issue:1 Topics: Amidohydrolases; Enzyme Induction; Enzyme Repression; Escherichia coli; Penicillanic Acid; Penicillin Amidase; Phenylacetates	1981
Inhibition of beta-lactamase of Bacillus licheniformis 749/C by compound PS-5, a new beta-lactam antibiotic. The Biochemical journal, 1980, Jan-01, Volume: 185, Issue:1 Topics: Ampicillin; Anti-Bacterial Agents; Bacillus; beta-Lactamase Inhibitors; beta-Lactams; Cephaloridine; Computers; Hydrolysis; Kinetics; Models, Chemical; Penicillanic Acid; Penicillin G; Spectrophotometry, Ultraviolet; Thienamycins	1980
Simple beta-lactam compounds derived from 6-aminopenicillanic acid. Journal of medicinal chemistry, 1980, Volume: 23, Issue:7 Topics: Bacteria; beta-Lactams; Drug Synergism; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins	1980
Estimation of penicillin concentrations and penicillin metabolising enzyme activities by the Lowry reaction. The Journal of antibiotics, 1980, Volume: 33, Issue:11 Topics: Calorimetry; Chemical Phenomena; Chemistry; Penicillanic Acid; Penicillin G; Penicillinase; Penicillins	1980
The evolution of the broad-spectrum penicillins. The Journal of antimicrobial chemotherapy, 1982, Volume: 9 Suppl B Topics: Ampicillin; Carbenicillin; History, 20th Century; Lactams; Penicillanic Acid; Penicillins; Pseudomonas; Thienamycins	1982
Interaction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases. The Biochemical journal, 1981, Oct-01, Volume: 199, Issue:1 Topics: Actinomycetaceae; Amdinocillin; beta-Lactams; Carboxypeptidases; Cefoxitin; Cephalosporins; Clavulanic Acid; Drug Interactions; Endopeptidases; Enzyme Inhibitors; Imipenem; Kinetics; Penicillanic Acid; Penicillins; Quinoxalines; Serine-Type D-Ala-D-Ala Carboxypeptidase; Streptomyces; Zinc	1981
Ionic strength and pH effects in the kinetically controlled synthesis of benzylpenicillin by nucleophilic deacylation of free and immobilized phenyl-acetyl-penicillin amidase with 6-aminopenicillanic acid. Biochemical and biophysical research communications, 1982, Feb-26, Volume: 104, Issue:4 Topics: Amidohydrolases; Enzymes, Immobilized; Glycine; Hydrogen-Ion Concentration; Kinetics; Osmolar Concentration; Penicillanic Acid; Penicillin Amidase; Penicillin G; Phenylacetates	1982
beta-Lactamase inhibition by 6 alpha-thiocyanatopenicillanic acids. The Journal of antibiotics, 1982, Volume: 35, Issue:3 Topics: Bacteria; beta-Lactamase Inhibitors; Penicillanic Acid	1982
[Beta-lactam antibiotics and the immune system of the body]. Acta microbiologica Bulgarica, 1981, Volume: 9 Topics: Animals; Anti-Bacterial Agents; Antibody Formation; Blood; Cephalothin; Dose-Response Relationship, Immunologic; Female; Immunity, Cellular; Male; Mice; Penicillanic Acid; Phagocytosis; Rabbits; Rats; Rats, Inbred Strains; Time Factors	1981
[Anticomplement action of carbiphen, amopen and cephalothin in vitro and in vivo]. Acta microbiologica Bulgarica, 1981, Volume: 9 Topics: Animals; Anti-Bacterial Agents; Cephalothin; Complement Inactivator Proteins; Complement System Proteins; Female; Guinea Pigs; In Vitro Techniques; Male; Penicillanic Acid; Rats; Rats, Inbred Strains; Time Factors	1981
Application of the fluorescamine reaction with 6-aminopenicillanic acid to estimation and detection of penicillin acylase activity. Antimicrobial agents and chemotherapy, 1983, Volume: 23, Issue:1 Topics: Amidohydrolases; Bacteria; Fluorescamine; Fluorescence; Hydrogen-Ion Concentration; Kinetics; Penicillanic Acid; Penicillin Amidase; Spiro Compounds	1983
[Mezlocillin: a penicillin from the acylureido series. Synthesis and chemical properties]. Arzneimittel-Forschung, 1983, Volume: 33, Issue:1 Topics: Chemical Phenomena; Chemistry; Hydrolysis; Mezlocillin; Penicillanic Acid; Penicillinase; Penicillins	1983
Synthesis of N-(2-hydroxypropyl)methacrylamide copolymers with antimicrobial activity. Biomaterials, 1983, Volume: 4, Issue:1 Topics: Acrylates; Ampicillin; Anti-Bacterial Agents; Bacteria; Kinetics; Methacrylates; Penicillanic Acid	1983
Bacillus cereus 569/H penicillinase serine-44 acylation by diazotized 6-aminopenicillanic acid. Biochimica et biophysica acta, 1983, Jun-29, Volume: 745, Issue:3 Topics: Acylation; Affinity Labels; Amino Acids; Bacillus cereus; beta-Lactamases; Chemical Phenomena; Chemistry; Mass Spectrometry; Penicillanic Acid; Penicillinase; Peptide Fragments; Protein Binding; Serine; Spores, Bacterial	1983
In-beam electron ionization mass spectra of penicillins. Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:5 Topics: Ampicillin; Chemical Phenomena; Chemistry, Physical; Mass Spectrometry; Penicillanic Acid; Penicillin V; Penicillins	1983
[Toxicology of 6-aminopenicillanic acid, chief product of the manufacture of semisynthetic penicillins]. Gigiena truda i professional'nye zabolevaniia, 1983, Issue:5 Topics: Animals; Guinea Pigs; Male; Mice; Penicillanic Acid; Rabbits; Rats	1983
Simple screening method for isolation of penicillin acylase-producing bacteria. Applied and environmental microbiology, 1983, Volume: 46, Issue:5 Topics: Amidohydrolases; Bacillus; Bacteria; Bacteriological Techniques; Biological Assay; Escherichia coli; Penicillanic Acid; Penicillin Amidase; Penicillin G; Serratia marcescens	1983
Continuous 6-APA and 7-ADCA production using Semacylase (immobilized PEN-V acylase). Annals of the New York Academy of Sciences, 1983, Volume: 413 Topics: Amidohydrolases; Cephalosporins; Enzymes, Immobilized; Kinetics; Penicillanic Acid; Penicillin Amidase; Structure-Activity Relationship	1983
Spectrophotometric determination of 6-aminopenicillanic and 7-aminocephalosporanic acids as the Schiff bases with para-dimethylaminobenzaldehyde in the presence of sodium dodecyl sulfate micelles. Analytical biochemistry, 1995, Aug-10, Volume: 229, Issue:2 Topics: Benzaldehydes; Cephalosporins; Indicators and Reagents; Kinetics; Micelles; Microcomputers; Penicillanic Acid; Schiff Bases; Sensitivity and Specificity; Sodium Dodecyl Sulfate; Spectrophotometry; Time Factors	1995
Solid-state 13C nuclear magnetic resonance spectra of 6-aminopenicillanic acid. Solid state nuclear magnetic resonance, 1995, Volume: 4, Issue:3 Topics: Magnetic Resonance Spectroscopy; Penicillanic Acid	1995
8-Hydroxypenillic acid: NMR characteristics and facile formation from 6-aminopenicillanic acid. The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:6 Topics: Imidazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Penicillanic Acid; Thiazoles	1994
A new, highly sensitive method for the detection and quantification of penicillin-binding proteins. The Biochemical journal, 1993, Apr-01, Volume: 291 ( Pt 1) Topics: Actinomycetales; Bacillus; Bacterial Proteins; Carrier Proteins; Cell Membrane; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Fluorescein; Fluoresceins; Fluorescent Dyes; Hexosyltransferases; Muramoylpentapeptide Carboxypeptidase; Penicillanic Acid; Penicillin G; Penicillin-Binding Proteins; Peptidyl Transferases; Sequence Analysis, DNA; Streptomyces; Succinimides	1993
Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry. The Biochemical journal, 1993, Sep-01, Volume: 294 ( Pt 2) Topics: Acetates; Acetic Acid; Acylation; Acyltransferases; Electrophoresis, Polyacrylamide Gel; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Weight; Penicillanic Acid; Penicillin-Binding Proteins; Penicillium chrysogenum; Protein Precursors; Protein Processing, Post-Translational	1993
[From penicillin to the progress in beta-lactams. Chronicle of a 50th anniversary]. Revue medicale de Liege, 1996, Volume: 51, Issue:1 Topics: Anti-Bacterial Agents; Cephalosporins; History, 20th Century; Humans; Penicillanic Acid; Penicillins	1996
[Antagonistic effect of oleanolic acid on anaphylactic shock]. Zhongguo yao li xue bao = Acta pharmacologica Sinica, 1995, Volume: 16, Issue:6 Topics: Anaphylaxis; Animals; Anti-Allergic Agents; Antibody Formation; Cell Degranulation; Female; Guinea Pigs; Histamine; Lung; Male; Mast Cells; Oleanolic Acid; Penicillanic Acid; Rats; Rats, Wistar	1995
Phenoxymethylpenicillin amidohydrolases from Penicillium chrysogenum. FEBS letters, 1996, Sep-23, Volume: 394, Issue:1 Topics: Cephalosporins; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Enzyme Stability; Hydrogen-Ion Concentration; Molecular Structure; Molecular Weight; Penicillanic Acid; Penicillin Amidase; Penicillin V; Penicillium chrysogenum; Substrate Specificity; Temperature	1996
The inhibitory mechanisms of glucose and carbon dioxide on the biosyntheses of penicillins and cephalosporins. Journal of biotechnology, 1996, Nov-01, Volume: 51, Issue:2 Topics: Acremonium; Acylation; Biotechnology; Carbohydrate Metabolism; Carbon Dioxide; Cephalosporins; Glucose; Penicillanic Acid; Penicillin G; Penicillins; Penicillium chrysogenum	1996
Regulation of beta-lactamase synthesis as a novel site of action for suppression of methicillin resistance in Staphylococcus aureus. Zentralblatt fur Bakteriologie : international journal of medical microbiology, 1997, Volume: 285, Issue:3 Topics: Bacterial Proteins; beta-Lactamases; Carrier Proteins; Cell Membrane; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hexosyltransferases; Methicillin; Methicillin Resistance; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillanic Acid; Penicillin G; Penicillin-Binding Proteins; Penicillins; Peptidyl Transferases; Polidocanol; Polyethylene Glycols; Signal Transduction; Staphylococcus aureus	1997
Evaluation of affinity and pseudo-affinity adsorption processes for penicillin acylase purification. Bioseparation, 1996, Volume: 6, Issue:5 Topics: Adsorption; Affinity Labels; Amoxicillin; Ampicillin; Chromatography, Affinity; Escherichia coli; Ethanolamine; Ethanolamines; Hydrogen-Ion Concentration; Ligands; Models, Chemical; Penicillanic Acid; Penicillin Amidase; Penicillin G; Sepharose	1996
Nitric oxide inhibition of coxsackievirus replication in vitro. The Journal of clinical investigation, 1997, Oct-01, Volume: 100, Issue:7 Topics: Cell Survival; Dose-Response Relationship, Drug; Enterovirus; HeLa Cells; Humans; Nitric Oxide; Nitric Oxide Synthase; Penicillanic Acid; RNA, Viral; Transfection; Viral Proteins; Virus Replication	1997
Novel strategy for efficient screening and construction of host/vector systems to overproduce penicillin acylase in Escherichia coli. Biotechnology and bioengineering, 1999, Oct-20, Volume: 65, Issue:2 Topics: Bioreactors; Escherichia coli; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Genetic Vectors; Molecular Structure; Mutagenesis; Penicillanic Acid; Penicillin Amidase; Penicillins; Plasmids; Recombinant Proteins	1999
A kinetic study of synthesis of amoxicillin using penicillin G acylase immobilized on agarose. Applied biochemistry and biotechnology, 2000,Spring, Volume: 84-86 Topics: Amoxicillin; Catalysis; Enzymes, Immobilized; Escherichia coli; Kinetics; Penicillanic Acid; Penicillin Amidase; Recombinant Proteins; Sepharose	2000
Synthesis and antibacterial activity of new arylamido derivatives of 6 beta-aminopenicillanic, 7 beta-aminocephalosporanic and 7 beta-aminodesacetoxycephalosporanic acids. Arzneimittel-Forschung, 2000, Volume: 50, Issue:7 Topics: Bacillus; Bacteria; Cephalosporins; Chemical Phenomena; Chemistry, Physical; Culture Media; Escherichia coli; Microbial Sensitivity Tests; Penicillanic Acid; Penicillins; Staphylococcus aureus	2000
Penicillin acylase catalyzed synthesis of penicillin-G from substrates anchored in cyclodextrins. Indian journal of biochemistry & biophysics, 2000, Volume: 37, Issue:1 Topics: Carbohydrates; Cyclodextrins; Penicillanic Acid; Penicillin Amidase; Penicillin G; Phenylacetates; Substrate Specificity	2000
Optimization of 6-aminopenicillanic acid (6-APA) production by using a new immobilized penicillin acylase. Biotechnology and applied biochemistry, 2000, Volume: 32, Issue:3 Topics: Enzymes, Immobilized; Hydrogen-Ion Concentration; Hydrolysis; Penicillanic Acid; Penicillin Amidase; Penicillin V; Streptomyces; Temperature	2000
Kinetics of ampicillin synthesis catalyzed by penicillin acylase from E. coli in homogeneous and heterogeneous systems. Quantitative characterization of nucleophile reactivity and mathematical modeling of the process. Biochemistry. Biokhimiia, 2000, Volume: 65, Issue:12 Topics: Ampicillin; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Models, Chemical; Models, Theoretical; Penicillanic Acid; Penicillin Amidase; Temperature	2000
Highly efficient synthesis of ampicillin in an "aqueous solution-precipitate" system: repetitive addition of substrates in a semicontinuous process. Biotechnology and bioengineering, 2001, Jun-05, Volume: 73, Issue:5 Topics: Ampicillin; Chemical Precipitation; Escherichia coli; Models, Theoretical; Penicillanic Acid; Penicillin Amidase; Solutions; Water	2001
The effect of a functional group in penicillin derivatives on the interaction with bile salt micelles studied by micellar electrokinetic chromatography. Electrophoresis, 2001, Volume: 22, Issue:16 Topics: Chromatography, Micellar Electrokinetic Capillary; Deoxycholic Acid; Energy Transfer; Micelles; Molecular Structure; Penicillanic Acid; Taurocholic Acid	2001
Biotransformations catalyzed by multimeric enzymes: stabilization of tetrameric ampicillin acylase permits the optimization of ampicillin synthesis under dissociation conditions. Biomacromolecules, 2001,Spring, Volume: 2, Issue:1 Topics: Acetobacter; Ampicillin; Bioreactors; Catalysis; Enzyme Stability; Enzymes, Immobilized; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Kinetics; Methanol; Molecular Structure; Penicillanic Acid; Penicillin Amidase; Phosphates; Protein Structure, Quaternary; Temperature	2001
Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production. Applied microbiology and biotechnology, 2001, Volume: 57, Issue:3 Topics: Adipates; Cephalosporins; Fructose; Gluconates; Glucose; Intramolecular Transferases; Mutagenesis, Insertional; Penicillanic Acid; Penicillin-Binding Proteins; Penicillium chrysogenum; Streptomyces; Sucrose	2001
Comparison of aqueous and nonaqueous carrier electrolytes for the separation of penicillin V and related substances by capillary electrophoresis with UV and mass spectrometric detection. Electrophoresis, 2002, Volume: 23, Issue:3 Topics: Acetates; Acetonitriles; Buffers; Electrolytes; Electrophoresis, Capillary; Ethanol; Imidazoles; Methanol; Penicillanic Acid; Penicillin V; Penicillins; Pipecolic Acids; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Ultraviolet; Thiazoles; Water	2002
Equilibrium modeling of extractive enzymatic hydrolysis of penicillin G with concomitant 6-aminopenicillanic acid crystallization. Biotechnology and bioengineering, 2002, May-20, Volume: 78, Issue:4 Topics: Acetates; Catalysis; Chromatography, High Pressure Liquid; Computer Simulation; Crystallization; Escherichia coli; Fermentation; Glycine; Hydrogen-Ion Concentration; Hydrolysis; Models, Chemical; Penicillanic Acid; Penicillin Amidase; Penicillin G; Potassium; Reproducibility of Results; Sensitivity and Specificity; Water	2002
Monitoring of enzymatic hydrolysis of penicillin G by pyrolysis-negative ion mass spectrometry. Journal of pharmaceutical and biomedical analysis, 2002, Jul-01, Volume: 29, Issue:3 Topics: Chromatography, High Pressure Liquid; Enzymes, Immobilized; Hydrogen-Ion Concentration; Hydrolysis; Mass Spectrometry; Penicillanic Acid; Penicillin Amidase; Penicillin G; Phenylacetates; Temperature	2002
Role of alphaArg145 and betaArg263 in the active site of penicillin acylase of Escherichia coli. The Biochemical journal, 2002, Jul-01, Volume: 365, Issue:Pt 1 Topics: Arginine; Base Sequence; Catalytic Domain; Escherichia coli; Gene Expression; Genes, Bacterial; Hydrogen-Ion Concentration; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Penicillanic Acid; Penicillin Amidase; Recombinant Proteins; Substrate Specificity	2002
Penicillin acylase-catalyzed ampicillin synthesis using a pH gradient: a new approach to optimization. Biotechnology and bioengineering, 2002, Jun-05, Volume: 78, Issue:5 Topics: Ampicillin; Catalysis; Cell Line; Escherichia coli; Glycine; Hydrogen-Ion Concentration; Models, Chemical; Penicillanic Acid; Penicillin Amidase; Protons; Quality Control; Sensitivity and Specificity	2002
Enzymatic synthesis of amoxicillin: avoiding limitations of the mechanistic approach for reaction kinetics. Biotechnology and bioengineering, 2002, Dec-20, Volume: 80, Issue:6 Topics: Amoxicillin; Bioreactors; Computer Simulation; Enzymes, Immobilized; Gels; Glycine; Kinetics; Models, Chemical; Neural Networks, Computer; Penicillanic Acid; Penicillin Amidase; Quality Control; Reproducibility of Results; Sensitivity and Specificity; Sepharose	2002
Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions. Biochimica et biophysica acta, 2002, Sep-23, Volume: 1599, Issue:1-2 Topics: Catalysis; Cephalosporins; Penicillanic Acid; Penicillin Amidase; Substrate Specificity	2002
[Determination of degraded products of penicillin by high performance liquid chromatography]. Se pu = Chinese journal of chromatography, 2001, Volume: 19, Issue:1 Topics: Chromatography, High Pressure Liquid; Drug Stability; Penicillanic Acid; Penicillin Amidase; Penicillin G; Phenylacetates	2001
The effect of an enhanced infection-control policy on the incidence of Clostridium difficile infection and methicillin-resistant Staphyloccocus aureus colonization in acute elderly medical patients. Age and ageing, 1998, Volume: 27, Issue:5 Topics: Aged; Cephalosporins; Clostridioides difficile; Communicable Disease Control; Cross Infection; Cross-Sectional Studies; Drug Utilization; England; Enterocolitis, Necrotizing; Hand Disinfection; Humans; Methicillin Resistance; Penicillanic Acid; Staphylococcal Infections; Staphylococcus aureus; Trimethoprim	1998
Inhibitory effects in the side reactions occurring during the enzymic synthesis of amoxicillin: p-hydroxyphenylglycine methyl ester and amoxicillin hydrolysis. Biotechnology and applied biochemistry, 2003, Volume: 38, Issue:Pt 1 Topics: Amoxicillin; Enzyme Inhibitors; Enzymes, Immobilized; Glycine; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Methanol; Models, Theoretical; Penicillanic Acid; Penicillin Amidase	2003
Adsorption of components of enzymatic synthesis of ampicillin on different hydrophobic resins. Applied biochemistry and biotechnology, 2003,Spring, Volume: 105 -108 Topics: Adsorption; Ampicillin; Chromatography; Hydrogen-Ion Concentration; Kinetics; Penicillanic Acid; Thermodynamics	2003
Study of nucleophile binding in the penicillin acylase active center. Kinetic analysis. Biochemistry. Biokhimiia, 2003, Volume: 68, Issue:3 Topics: Aminobenzoates; Binding Sites; Catalysis; Escherichia coli Proteins; Hydrolysis; Kinetics; Penicillanic Acid; Penicillin Amidase; Reproducibility of Results; Substrate Specificity	2003
Continuous penicillin G hydrolysis in an electro-membrane reactor with immobilized penicillin G acylase. Biotechnology letters, 2003, Volume: 25, Issue:6 Topics: Bioreactors; Electrochemistry; Electromagnetic Fields; Enzyme Activation; Enzymes, Immobilized; Equipment Design; Hydrolysis; Membranes, Artificial; Penicillanic Acid; Penicillin Amidase; Penicillin G	2003
Kinetics of enzyme acylation and deacylation in the penicillin acylase-catalyzed synthesis of beta-lactam antibiotics. European journal of biochemistry, 2003, Volume: 270, Issue:18 Topics: Acylation; Anti-Bacterial Agents; Binding Sites; Binding, Competitive; Catalysis; Cephalosporins; Deuterium; Escherichia coli; Glycine; Hydrolysis; Kinetics; Penicillanic Acid; Penicillin Amidase; Phenylacetates; Protons; Spectrophotometry, Ultraviolet; Substrate Specificity	2003
Synthesis of penicillin: 6-aminopenicillanic acid in penicillin fermentations. Nature, 1959, Jan-24, Volume: 183, Issue:4656 Topics: Fermentation; Penicillanic Acid; Penicillins	1959
Identification of a compound related to 6-aminopenicillanic acid, isolated from culture media of Penicillium chrysogenum. Nature, 1961, Aug-26, Volume: 191 Topics: Culture Media; Penicillanic Acid; Penicillins; Penicillium; Penicillium chrysogenum	1961
6-Aminopenicillanic acid in urine after oral administration of penicillins. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1960, Volume: 104 Topics: Administration, Oral; Body Fluids; Humans; Inactivation, Metabolic; Penicillanic Acid; Penicillins	1960
Action of 6-aminopenicillanic acid on gram-negative bacteria. Nature, 1960, Dec-03, Volume: 188 Topics: Bacteria; Gram-Negative Bacteria; Penicillanic Acid; Penicillins	1960
6-Aminopenicillanic acid. Chemotherapia, 1961, Volume: 2 Topics: Humans; Penicillanic Acid; Penicillins	1961
A method for isolating bacteria capable of producing 6-aminopenicillanic acid from benzylpenillin. Nature, 1961, Sep-09, Volume: 191 Topics: Bacteria; Penicillanic Acid; Penicillium; Soil; Soil Microbiology	1961
Formation of 6-aminopenicillanic acid by alkaline hydrolysis of penicillins. Nature, 1962, Sep-08, Volume: 195 Topics: Hydrolysis; Penicillanic Acid; Penicillins	1962
The treatment of acutely x-irradiated mice with streptomycin and derivatives of 6-aminopenicillanic acid. British journal of experimental pathology, 1962, Volume: 43 Topics: Animals; Mice; Penicillanic Acid; Penicillins; Radiation Injuries, Experimental; Streptomycin	1962
Excretion of antibiotics in bile. British journal of pharmacology and chemotherapy, 1961, Volume: 17 Topics: Ampicillin; Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Bile; Biological Transport; Body Fluids; Chloramphenicol; Neomycin; Paromomycin; Penicillanic Acid; Penicillin G; Penicillins; Rats; Streptomycin	1961
Distribution and substrate specificity of benzylpenicillin acylase. Applied microbiology, 1963, Volume: 11 Topics: Cephalosporins; Esterases; Nocardia; Penicillanic Acid; Penicillin Amidase; Penicillin G; Penicillins; Proteus; Substrate Specificity	1963
[A simple rapid method for the determination of 6-aminopenicillanic acid]. Kiserletes orvostudomany, 1962, Volume: 14 Topics: Penicillanic Acid; Penicillins	1962
DERIVATIVES OF 6- AMINOPENICILLANIC ACID. III. REACTIONS WITH N-SUBSTITUTED PHTHALAMIC ACIDS. Journal of medicinal and pharmaceutical chemistry, 1962, Volume: 5 Topics: Bacteria; Chemical Phenomena; Chemistry; Penicillanic Acid; Penicillinase; Penicillins; Pharmacology; Phthalic Acids; Research; Staphylococcus	1962
NOTES ON PREPARATION OF 6-AMINOPENICILLANIC ACID BY BACTERIAL HYDROLYSIS OF BENZYLPENICILLIN. Folia microbiologica, 1963, Volume: 40 Topics: Bacteria; Biochemical Phenomena; Biochemistry; Hydrolysis; Penicillanic Acid; Penicillin G; Penicillins; Research	1963
PRODUCTION OF 6-AMINOPENICILLANIC ACID BY DERMATOPHYTES. Nature, 1963, Nov-30, Volume: 200 Topics: Arthrodermataceae; Chromatography; Epidermophyton; Metabolism; Penicillanic Acid; Penicillin G; Penicillin V; Penicillins; Research; Trichophyton	1963
[DERIVATIVES OF 6-AMINOPENICILLANIC ACID. III. (1). NEW SEMISYNTHETIC PENICILLIN: ALPHA-SUBSTITUTED BETA-HALOGENO- AND BETA-ACETOXYETHYLPENICILLIN]. Il Farmaco; edizione scientifica, 1963, Volume: 18 Topics: Bacteria; Chemistry, Pharmaceutical; Ethylenediamines; Methicillin; Penicillanic Acid; Penicillin G; Penicillin G Benzathine; Penicillin V; Penicillins; Pharmacology	1963
6-AMINOPENICILLANIC ACID: INHIBITION OF DESTRUCTION OF CEPHALOSPORIN C BY BACTERIA. Science (New York, N.Y.), 1964, Mar-27, Volume: 143, Issue:3613 Topics: Acremonium; Aeromonas; Alcaligenes; Anti-Bacterial Agents; Bacillus subtilis; Bacteria; Cephalosporins; Enterobacter aerogenes; Enzyme Inhibitors; Erwinia; Escherichia coli; Lactobacillus; Penicillanic Acid; Penicillins; Propionibacterium; Proteins; Proteus; Pseudomonas; Pseudomonas aeruginosa; Research; Serratia marcescens; Staphylococcus; Vibrio	1964
ANTIBACTERIAL ACTIVITY OF SOME DERIVATIVES OF 7-AMINOCEPHALOSPORANIC ACID AGAINST STAPHYLOCOCCUS AUREUS AND SYNERGISM BETWEEN THESE AND OTHER ANTIBIOTICS. British journal of pharmacology and chemotherapy, 1964, Volume: 22 Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Cephalosporins; Coagulase; Drug Resistance; Drug Resistance, Microbial; Fusidic Acid; Methicillin; Mice; Penicillanic Acid; Penicillin G; Penicillinase; Pharmacology; Research; Staphylococcal Infections; Staphylococcus; Staphylococcus aureus	1964
HAEMAGGLUTINATION OF ERYTHROCYTES COATED WITH 6-AMINOPENICILLANIC ACID. Nature, 1964, Jul-25, Volume: 203 Topics: Carbon Dioxide; Erythrocytes; Hemagglutination; Penicillanic Acid; Penicillins; Research; Toxicology	1964
METABOLIC CONTROL OF PENICILLINASE BIOSYNTHESIS IN BACILLUS CEREUS. Journal of bacteriology, 1964, Volume: 88 Topics: Azaguanine; Bacillus cereus; Cephalosporins; Cytosine; Dactinomycin; Enzyme Inhibitors; Mercury; Penicillanic Acid; Penicillin G; Penicillinase; Penicillins; Pharmacology; Proteins; Research; RNA; RNA, Messenger; Thymine; Uracil	1964
THE EFFECT OF PROBENECID IN DELAYING THE URINARY EXCRETIONS OF THE NEW PENICILLINS DERIVED FROM 6-AMINOPENICILLANIC ACID. The British journal of clinical practice, 1964, Volume: 18 Topics: Ampicillin; Biomedical Research; Blood; Dosage Forms; Endocarditis; Endocarditis, Bacterial; Humans; Injections, Intramuscular; Methicillin; Penicillanic Acid; Penicillin V; Penicillins; Pharmacology; Probenecid; Streptococcal Infections; Urine	1964
DERIVATIVES OF 6-AMINOPENICILLANIC ACID. V. SYNTHESIS OF 6-AMINOPENICILLANYL ALCOHOL AND CERTAIN DERIVATIVES. Journal of medicinal chemistry, 1964, Volume: 7 Topics: Alcohols; Chemistry, Pharmaceutical; Ethanol; Penicillanic Acid; Penicillins; Pharmacology; Research; Staphylococcus	1964
[DERIVATIVES OF 6-AMINOPENICILLANIC ACID. IV. (1). A NEW WIDE-SPECTRUM PENICILLIN: D(-)ALPHA-PHENYL-BETA-AMINOETHYLPENICILLIN (BETACIN)]. Il Farmaco; edizione scientifica, 1964, Volume: 19 Topics: Bacteria; Chemistry, Pharmaceutical; Penicillanic Acid; Penicillins; Pharmacology; Pharmacy; Research	1964
AUTOMATED COLORIMETRIC DETERMINATION OF 6-AMINOPENICILLANIC ACID IN FERMENTATION MEDIA. Analytical chemistry, 1965, Volume: 37 Topics: Chemistry Techniques, Analytical; Colorimetry; Fermentation; Penicillanic Acid; Penicillins; Research	1965
COMMON ANTIGENIC DETERMINANTS OF PENICILLIN G, CEPHALOTHIN AND 6-AMINOPENICILLANIC ACID IN RABBITS. Journal of immunology (Baltimore, Md. : 1950), 1965, Volume: 94 Topics: Animals; Anti-Bacterial Agents; Antigen-Antibody Reactions; Cephalothin; Electrophoresis; Epitopes; Hemagglutination; Hemagglutination Inhibition Tests; Hemagglutination Tests; Hypersensitivity; Immunodiffusion; Passive Cutaneous Anaphylaxis; Penicillanic Acid; Penicillin G; Penicillins; Precipitin Tests; Rabbits; Research	1965
Formation of 6-aminopenicillanic acid from penicillin by enzymatic hydrolysis. Nature, 1960, Jul-16, Volume: 187 Topics: Hydrolysis; Penicillanic Acid; Penicillins	1960
6-Aminopenicillanic acid. V. 6-Aminopenicillanic acid as a substrate for penicillinase and an inducer of penicillinase formation. Proceedings of the Royal Society of London. Series B, Biological sciences, 1961, Aug-15, Volume: 154 Topics: Penicillanic Acid; Penicillinase; Penicillins	1961
6-Aminopenicillanic acid. III. Isolation and purification. Proceedings of the Royal Society of London. Series B, Biological sciences, 1961, Aug-15, Volume: 154 Topics: Penicillanic Acid; Penicillins	1961
6-Aminopenicillanic acid. VI. Formation of 6-aminopenicillanic acid from penicillin by enzymic hydrolysis. Proceedings of the Royal Society of London. Series B, Biological sciences, 1961, Aug-15, Volume: 154 Topics: Hydrolysis; Inactivation, Metabolic; Penicillanic Acid; Penicillins	1961
6-Aminopenicillanic acid. I. 6-Aminopenicillanic acid in penicillin fermentations. Proceedings of the Royal Society of London. Series B, Biological sciences, 1961, Aug-15, Volume: 154 Topics: Fermentation; Inactivation, Metabolic; Penicillanic Acid; Penicillins	1961
6-Aminopenicillanic acid. II. Formation of 6-aminopenicillanic acid by Emericellopsis minima (Stolk) and related fungi. Proceedings of the Royal Society of London. Series B, Biological sciences, 1961, Aug-15, Volume: 154 Topics: Fungi; Hypocreales; Penicillanic Acid; Penicillins	1961
6-Aminopenicillanic acid. Scientific reports of the Istituto superiore di sanita, 1961, Volume: 1 Topics: Humans; Penicillanic Acid; Penicillins	1961
Penicillin acylase-catalyzed synthesis of beta-lactam antibiotics in highly condensed aqueous systems: beneficial impact of kinetic substrate supersaturation. Biotechnology and bioengineering, 2004, Feb-05, Volume: 85, Issue:3 Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; beta-Lactams; Catalysis; Cephalexin; Cephalosporins; Enzyme Activation; Escherichia coli; Kinetics; Penicillanic Acid; Penicillin Amidase; Solutions; Substrate Specificity; Water	2004
Production of 6-aminopenicillanic acid in aqueous two-phase systems by recombinant Escherichia coli with intracellular penicillin acylase. Biotechnology letters, 2004, Volume: 26, Issue:2 Topics: Crystallization; Escherichia coli; Hydrogen-Ion Concentration; Penicillanic Acid; Penicillin Amidase; Penicillin G; Recombinant Proteins; Temperature	2004
Increasing the synthetic performance of penicillin acylase PAS2 by structure-inspired semi-random mutagenesis. Protein engineering, design & selection : PEDS, 2004, Volume: 17, Issue:7 Topics: beta-Lactams; Catalysis; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Escherichia coli; Genetic Techniques; Glycine; Hydrolysis; Kinetics; Models, Chemical; Mutagenesis; Mutation; Penicillanic Acid; Penicillin Amidase; Plasmids; Protein Conformation; Protein Engineering; Time Factors	2004
[Treatment mostly not in line with current knowledge. New guidelines for sinusitis therapy]. MMW Fortschritte der Medizin, 2004, Jun-10, Volume: 146, Issue:24 Topics: Acute Disease; Bacterial Infections; Ceftibuten; Cephalosporins; Chronic Disease; Clavulanic Acid; Drug Resistance, Multiple; Humans; Mometasone Furoate; Penicillanic Acid; Pregnadienediols; Sinusitis; Treatment Outcome	2004
UV irradiation and desiccation modulate the three-dimensional extracellular matrix of Nostoc commune (Cyanobacteria). The Journal of biological chemistry, 2005, Dec-02, Volume: 280, Issue:48 Topics: Amino Acid Sequence; Base Sequence; Chromatography, Liquid; Extracellular Matrix; Heat-Shock Proteins; Indoles; Isoelectric Focusing; Mass Spectrometry; Models, Chemical; Models, Genetic; Molecular Sequence Data; Nostoc commune; Open Reading Frames; Oxygen; Penicillanic Acid; Peptides; Phenols; Phylogeny; Polymorphism, Genetic; Polysaccharides; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Superoxide Dismutase; Transcription, Genetic; Ultraviolet Rays	2005
[Disseminated actinomycosis]. Revue des maladies respiratoires, 2005, Volume: 22, Issue:3 Topics: Actinomyces; Actinomycosis; Alcoholism; Amoxicillin; Brain Abscess; Brain Neoplasms; Bronchoalveolar Lavage Fluid; Consciousness Disorders; Diagnosis, Differential; Humans; Lung Diseases, Fungal; Male; Metronidazole; Middle Aged; Penicillanic Acid; Smoking; Tomography, X-Ray Computed	2005
Application of cross-linked enzyme aggregates of Bacillus badius penicillin G acylase for the production of 6-aminopenicillanic acid. Letters in applied microbiology, 2007, Volume: 44, Issue:1 Topics: Bacillus; Cross-Linking Reagents; Enzymes, Immobilized; Industrial Microbiology; Penicillanic Acid; Penicillin Amidase	2007
In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum. Applied microbiology and biotechnology, 2007, Volume: 76, Issue:1 Topics: Biological Transport; Culture Media; Down-Regulation; Genes, Fungal; Multigene Family; Penicillanic Acid; Penicillin G; Penicillins; Penicillium chrysogenum; Peroxisomes; Phenylacetates	2007
Molecularly imprinted polymers as antibody mimics in automated on-line fluorescent competitive assays. Analytical chemistry, 2007, Jul-01, Volume: 79, Issue:13 Topics: Amoxicillin; Ampicillin; Anti-Bacterial Agents; Antibody Specificity; Automation; beta-Lactams; Binding, Competitive; Chromatography; Fluoroimmunoassay; Molecular Mimicry; Nafcillin; Oxacillin; Penicillanic Acid; Penicillin G; Penicillin V; Polymers; Sensitivity and Specificity	2007
Site-specific protonation microequilibria of penicillin and cephalosporin beta-lactam core molecules. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 32, Issue:1 Topics: beta-Lactams; Cephalosporins; Hydrogen-Ion Concentration; Ions; Magnetic Resonance Spectroscopy; Osmolar Concentration; Penicillanic Acid; Penicillins; Potentiometry; Protons	2007
Calixarenes in a membrane environment: a monolayer study on the miscibility of three p-tert-butylcalix[4]arene beta-lactam derivatives with 1,2-dimyristoyl-sn-glycero-3-phosphoethanolamine. The journal of physical chemistry. B, 2007, Nov-22, Volume: 111, Issue:46 Topics: beta-Lactams; Calixarenes; Chemical Phenomena; Chemistry, Physical; Magnetic Resonance Spectroscopy; Membranes, Artificial; Models, Molecular; Penicillanic Acid; Phosphatidylethanolamines; Spectrophotometry, Ultraviolet	2007
[Phase transfer catalyzed bioconversion of penicillin G to 6-APA by immobilized penicillin acylase in recyclable aqueous two-phase systems with light/pH sensitive copolymers]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2008, Volume: 28, Issue:3 Topics: Catalysis; Enzymes, Immobilized; Hydrogen-Ion Concentration; Kinetics; Penicillanic Acid; Penicillin Amidase; Penicillin G; Phase Transition; Polymers; Substrate Specificity	2008
Fluorophore-labeled beta-lactamase as a biosensor for beta-lactam antibiotics: a study of the biosensing process. Journal of the American Chemical Society, 2008, May-21, Volume: 130, Issue:20 Topics: Anti-Bacterial Agents; beta-Lactamases; beta-Lactams; Biosensing Techniques; Cefuroxime; Circular Dichroism; Computer Simulation; Fluoresceins; Fluorescent Dyes; Kinetics; Mass Spectrometry; Models, Molecular; Penicillanic Acid; Penicillin G; Protein Denaturation; Spectrometry, Fluorescence	2008
Poststreptococcal dystonia with bilateral striatal enlargement: MR imaging and spectroscopic findings. AJNR. American journal of neuroradiology, 2008, Volume: 29, Issue:7 Topics: Aspartic Acid; Autoantibodies; Bacterial Proteins; Caudate Nucleus; Child; Deoxyribonucleases; Diffusion Magnetic Resonance Imaging; Dominance, Cerebral; Dystonia; Energy Metabolism; Follow-Up Studies; Humans; Hypertrophy; Image Processing, Computer-Assisted; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Male; Necrosis; Neurologic Examination; Penicillanic Acid; Pharyngitis; Putamen; Streptococcal Infections; Streptolysins	2008
Enzymatic hydrolysis of penicillin for 6-APA production in three-liquid-phase system. Applied biochemistry and biotechnology, 2008, Volume: 144, Issue:2 Topics: Alkanes; Biotechnology; Hydrolysis; Ionic Liquids; Kinetics; Molecular Structure; Penicillanic Acid; Penicillins; Phase Transition; Polyethylene Glycols; Propylene Glycols	2008
Free-radical destruction of beta-lactam antibiotics in aqueous solution. The journal of physical chemistry. A, 2008, Aug-14, Volume: 112, Issue:32 Topics: Anti-Bacterial Agents; beta-Lactams; Free Radicals; Hydroxyl Radical; Kinetics; Penicillanic Acid; Solutions; Time Factors; Water	2008
Small molecule inhibition of a Group II chaperonin: pinpointing a loop region within the equatorial domain as necessary for protein refolding. Archives of biochemistry and biophysics, 2009, Jan-01, Volume: 481, Issue:1 Topics: Archaeal Proteins; Chaperonins; Fluorescence Polarization; Methanococcaceae; Models, Molecular; Molecular Chaperones; Penicillanic Acid; Protein Binding; Protein Conformation; Protein Folding; Thermosomes	2009
6-aminopenicillanic acid production by intact cells of E. coli containing penicillin G acylase (PGA). Pakistan journal of biological sciences : PJBS, 2007, Sep-15, Volume: 10, Issue:18 Topics: Bacillus megaterium; Catalysis; Chemistry, Pharmaceutical; Crystallization; Escherichia coli; Fermentation; Filtration; Hydrogen-Ion Concentration; Oxygen; Penicillanic Acid; Penicillin Amidase; Phenylacetates; Temperature; Time Factors; Zea mays	2007
Comparative production of 6-aminopenicillanic acid by different E. coli strains and their acridine orange (AO) induced mutants. Pakistan journal of biological sciences : PJBS, 2007, Nov-01, Volume: 10, Issue:21 Topics: Acridine Orange; Catalysis; Chemistry, Pharmaceutical; Escherichia coli; Fluorescent Dyes; Industrial Microbiology; Models, Biological; Models, Statistical; Mutation; Penicillanic Acid; Penicillin G	2007
Synthesis and biological evaluation of penem inhibitors of bacterial signal peptidase. Bioorganic & medicinal chemistry letters, 2009, Jul-15, Volume: 19, Issue:14 Topics: Anti-Bacterial Agents; Membrane Proteins; Microbial Sensitivity Tests; Penicillanic Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Structure-Activity Relationship	2009
Human health risk assessment of penicillin/aminopenicillin resistance in enterococci due to penicillin use in food animals. Risk analysis : an official publication of the Society for Risk Analysis, 2009, Volume: 29, Issue:6 Topics: Animals; Animals, Domestic; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Intensive Care Units; Penicillanic Acid; Penicillins; Risk Assessment	2009
Monitoring bioreactors using principal component analysis: production of penicillin G acylase as a case study. Bioprocess and biosystems engineering, 2010, Volume: 33, Issue:5 Topics: Bacillus megaterium; Bacterial Proteins; Bioreactors; Penicillanic Acid; Penicillin Amidase; Penicillin G; Phenylacetates	2010
A process to produce penicillin G acylase by surface-adhesion fermentation using Mucor griseocyanus to obtain 6-aminopenicillanic acid by penicillin G hydrolysis. Applied biochemistry and biotechnology, 2010, Volume: 160, Issue:7 Topics: Biofilms; Cell Adhesion; Enzyme Activation; Enzymes, Immobilized; Fermentation; Hydrolysis; Opuntia; Penicillanic Acid; Penicillin Amidase; Penicillin G; Surface Properties	2010
FT-IR, FT-Raman, ab initio and DFT structural and vibrational frequency analysis of 6-aminopenicillanic acid. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2010, Volume: 75, Issue:1 Topics: Penicillanic Acid; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Thermodynamics; Vibration	2010
Enhanced production of 6-aminopenicillanic acid in aqueous methyl isobutyl ketone system with immobilized penicillin G acylase. Preparative biochemistry & biotechnology, 2010, Volume: 40, Issue:1 Topics: Bacillus megaterium; Catalysis; Enzymes, Immobilized; Hydrolysis; Methyl n-Butyl Ketone; Penicillanic Acid; Penicillin Amidase; Penicillin G; Water	2010
One-pot, two-step enzymatic synthesis of amoxicillin by complexing with Zn2+. Applied microbiology and biotechnology, 2010, Volume: 88, Issue:1 Topics: Amoxicillin; Biotechnology; Glycine; Kluyvera; Penicillanic Acid; Penicillin Amidase; Penicillin G; Technology, Pharmaceutical; Zinc	2010
Immobilization of penicillin G acylase on macro-mesoporous silica spheres. Bioresource technology, 2011, Volume: 102, Issue:2 Topics: Adsorption; Biocatalysis; Biotechnology; Enzyme Stability; Enzymes, Immobilized; Microspheres; Nitrogen; Penicillanic Acid; Penicillin Amidase; Porosity; Silicon Dioxide; Temperature; Time Factors	2011
Performance and model of a full-scale up-flow anaerobic sludge blanket (UASB) to treat the pharmaceutical wastewater containing 6-APA and amoxicillin. Journal of hazardous materials, 2011, Jan-30, Volume: 185, Issue:2-3 Topics: Amoxicillin; Anaerobiosis; Anti-Bacterial Agents; Biodegradation, Environmental; Models, Theoretical; Penicillanic Acid; Sewage; Water Pollutants, Chemical	2011
[Four recurrences of acute generalized exanthematous pustulosis (AGEP) with three different drugs in the same patient]. Annales de dermatologie et de venereologie, 2011, Volume: 138, Issue:5 Topics: Acute Generalized Exanthematous Pustulosis; Aged; Anti-Bacterial Agents; Dermatologic Agents; Erysipelas; Female; Humans; Intertrigo; Naphthalenes; Penicillanic Acid; Pristinamycin; Recurrence; Terbinafine	2011
Comparative study of 6-APA production by free and agar immobilized bacteria in nutrient broth culture. Indian journal of experimental biology, 2011, Volume: 49, Issue:4 Topics: Agar; Biotransformation; Cells, Immobilized; Culture Media; Gram-Positive Bacteria; India; Penicillanic Acid; Penicillin G; Soil Microbiology	2011
Ionization constants and solubility of compounds involved in enzymatic synthesis of aminopenicillins and aminocephalosporins. Bioprocess and biosystems engineering, 2011, Volume: 34, Issue:9 Topics: Amino Acids; beta-Lactams; Cephalosporins; Chemistry, Pharmaceutical; Drug Design; Electrolytes; Hydrogen-Ion Concentration; Ions; Models, Chemical; Models, Theoretical; Penicillanic Acid; Penicillins; Solubility; Temperature; Thermodynamics	2011
Penicillin inhibitors of purple acid phosphatase. Bioorganic & medicinal chemistry letters, 2012, Apr-01, Volume: 22, Issue:7 Topics: Acid Phosphatase; Acids, Carbocyclic; Acylation; Animals; Bone Density Conservation Agents; Bone Resorption; Catalytic Domain; Computer Simulation; Glycoproteins; Humans; Kinetics; Models, Molecular; Penicillanic Acid; Penicillins; Swine	2012
[Determination of penicillin intermediate and three penicillins in milk by high performance capillary electrophoresis]. Se pu = Chinese journal of chromatography, 2011, Volume: 29, Issue:11 Topics: Amoxicillin; Ampicillin; Animals; Cattle; Drug Residues; Electrophoresis, Capillary; Food Contamination; Milk; Penicillanic Acid; Penicillin G	2011
Modeling solubility, acid-base properties and activity coefficients of amoxicillin, ampicillin and (+)6-aminopenicillanic acid, in NaCl(aq) at different ionic strengths and temperatures. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2012, Nov-20, Volume: 47, Issue:4 Topics: Amoxicillin; Ampicillin; beta-Lactams; Hydrogen-Ion Concentration; Hydrolysis; Osmolar Concentration; Penicillanic Acid; Potentiometry; Sodium Chloride; Solubility; Solutions; Temperature; Water	2012
Ferrocenyl bioconjugates of ampicillin and 6-aminopenicillinic acid--synthesis, electrochemistry and biological activity. European journal of medicinal chemistry, 2012, Volume: 57 Topics: Ampicillin; Anti-Bacterial Agents; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Dipeptidases; Electrochemical Techniques; Enzyme Inhibitors; Ferrous Compounds; Humans; Magnetic Resonance Spectroscopy; Metallocenes; Methicillin-Resistant Staphylococcus aureus; Microbial Viability; Oxidation-Reduction; Penicillanic Acid; Spectrophotometry, Infrared; Staphylococcus aureus; Staphylococcus epidermidis; Vancomycin Resistance	2012
Penicillin G acylase from Achromobacter sp. CCM 4824 : an efficient biocatalyst for syntheses of beta-lactam antibiotics under conditions employed in large-scale processes. Applied microbiology and biotechnology, 2014, Volume: 98, Issue:3 Topics: Achromobacter; Amoxicillin; Ampicillin; Anti-Bacterial Agents; beta-Lactams; Biotransformation; Enzyme Stability; Enzymes, Immobilized; Hydrogen-Ion Concentration; Penicillanic Acid; Penicillin Amidase; Temperature	2014
Crystal structure and packing energy calculations of (+)-6-aminopenicillanic acid. Acta crystallographica. Section C, Crystal structure communications, 2013, Volume: 69, Issue:Pt 11 Topics: Carboxylic Acids; Crystallography, X-Ray; Hydrogen Bonding; Models, Molecular; Penicillanic Acid; Thermodynamics	2013
The trends in antibiotic use by general dental practitioners in the Czech Republic (2006-2012). International dental journal, 2014, Volume: 64, Issue:3 Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Clindamycin; Czech Republic; Databases, Factual; Drug Prescriptions; General Practice, Dental; Health Care Sector; Humans; Lincosamides; Macrolides; Metronidazole; Penicillanic Acid; Penicillins; Tetracyclines	2014
Enzymatic hydrolysis of penicillin and in situ product separation in thermally induced reversible phase-separation of ionic liquids/water mixture. Enzyme and microbial technology, 2014, Volume: 63 Topics: Chromatography, High Pressure Liquid; Hydrolysis; Hydrophobic and Hydrophilic Interactions; Ionic Liquids; Molecular Structure; Penicillanic Acid; Penicillin Amidase; Penicillin G; Temperature; Water	2014
Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. PloS one, 2015, Volume: 10, Issue:8 Topics: Animals; Antimicrobial Cationic Peptides; beta-Lactamases; Cathelicidins; DNA Transposable Elements; Gene Expression Regulation, Bacterial; Humans; Mice; Penicillanic Acid; Penicillin Resistance; Staphylococcal Infections; Staphylococcus aureus	2015
Haemophilus influenzae with Non-Beta-Lactamase-Mediated Beta-Lactam Resistance: Easy To Find but Hard To Categorize. Journal of clinical microbiology, 2015, Volume: 53, Issue:11 Topics: Ampicillin; Ampicillin Resistance; Anti-Bacterial Agents; beta-Lactamases; Cefuroxime; Disk Diffusion Antimicrobial Tests; Haemophilus Infections; Haemophilus influenzae; Humans; Penicillanic Acid; Penicillin-Binding Proteins	2015
In vivo kinetic analysis of the penicillin biosynthesis pathway using PAA stimulus response experiments. Metabolic engineering, 2015, Volume: 32 Topics: Acyltransferases; Algorithms; Carbon; Culture Media; Filtration; Glucose; Kinetics; Metabolic Networks and Pathways; Models, Biological; Penicillanic Acid; Penicillin-Binding Proteins; Penicillins; Penicillium chrysogenum; Phenylacetates	2015
Novel Penicillin-Type Analogues Bearing a Variable Substituted 2-Azetidinone Ring at Position 6: Synthesis and Biological Evaluation. Molecules (Basel, Switzerland), 2015, Dec-10, Volume: 20, Issue:12 Topics: Animals; Anti-Bacterial Agents; Azetidines; Bacillus; beta-Lactams; Cell Survival; Escherichia coli; Mice; Microbial Sensitivity Tests; NIH 3T3 Cells; Penicillanic Acid; Pseudomonas; Salmonella typhimurium; Staphylococcus; Structure-Activity Relationship	2015
Degradation Kinetics and Mechanism of a β-Lactam Antibiotic Intermediate, 6-Aminopenicillanic Acid, in a New Integrated Production Process. Journal of pharmaceutical sciences, 2016, Volume: 105, Issue:1 Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Hydrolysis; Kinetics; Models, Chemical; Penicillanic Acid; Solutions; Technology, Pharmaceutical; Temperature	2016
Biotransformation of penicillin V to 6-aminopenicillanic acid using immobilized whole cells of E. coli expressing a highly active penicillin V acylase. Preparative biochemistry & biotechnology, 2017, Jan-02, Volume: 47, Issue:1 Topics: Alginates; Biotransformation; Escherichia coli; Glucuronic Acid; Hexuronic Acids; Microscopy, Electron, Scanning; Penicillanic Acid; Penicillin Amidase; Penicillin V; Permeability	2017
Partial Least-Squares and Linear Support Vector Regression Chemometric Methods for Simultaneous Determination of Amoxicillin Trihydrate and Dicloxacillin Sodium in the Presence of Their Common Impurity. Journal of AOAC International, 2016, Volume: 99, Issue:4 Topics: Amoxicillin; Capsules; Dicloxacillin; Drug Contamination; Penicillanic Acid; Regression Analysis; Spectrophotometry, Ultraviolet	2016
Preparation and Biochemical Property of Penicillin G Amidase-Loaded Alginate and Alginate/Chitosan Hydrogel Beads. Recent patents on biotechnology, 2016, Volume: 10, Issue:1 Topics: Alginates; Chitosan; Glucuronic Acid; Hexuronic Acids; Hydrogel, Polyethylene Glycol Dimethacrylate; Hydrogen-Ion Concentration; Patents as Topic; Penicillanic Acid; Penicillin Amidase; Penicillin G	2016
Subcritical water oxidation of 6-aminopenicillanic acid and cloxacillin using H Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering, 2017, Feb-23, Volume: 52, Issue:3 Topics: Anti-Bacterial Agents; Cloxacillin; Environmental Restoration and Remediation; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Ion Exchange Resins; Oxidation-Reduction; Penicillanic Acid; Sulfates; Temperature; Water Pollutants, Chemical; Water Purification	2017
Pharmaceutical Intermediate-Modified Gold Nanoparticles: Against Multidrug-Resistant Bacteria and Wound-Healing Application via an Electrospun Scaffold. ACS nano, 2017, 06-27, Volume: 11, Issue:6 Topics: Animals; Anti-Bacterial Agents; Bacteria; Bandages; Gold; Metal Nanoparticles; Nanofibers; Penicillanic Acid; Polyesters; Rats, Sprague-Dawley; Wound Healing; Wound Infection	2017
Chromatographic Methods for Quantitative Determination of Ampicillin, Dicloxacillin and Their Impurity 6-Aminopenicillanic Acid. Journal of chromatographic science, 2018, Mar-01, Volume: 56, Issue:3 Topics: Ampicillin; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dicloxacillin; Drug Contamination; Limit of Detection; Linear Models; Penicillanic Acid; Reproducibility of Results	2018
Optimization of aqueous two-phase systems for the production of 6-aminopenicillanic acid in integrated microfluidic reactors-separators. New biotechnology, 2018, Dec-25, Volume: 47 Topics: Buffers; Dextrans; Microfluidics; Molecular Weight; Penicillanic Acid; Phosphates; Polyethylene Glycols; Viscosity	2018
Directed evolution of a penicillin V acylase from Bacillus sphaericus to improve its catalytic efficiency for 6-APA production. Enzyme and microbial technology, 2018, Volume: 119 Topics: Bacillus; Catalysis; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Penicillanic Acid; Penicillin Amidase; Protein Conformation; Substrate Specificity	2018
Shielding of Enzymes on the Surface of Graphene-Based Composite Cellular Foams Through Bioinspired Mineralization. Methods in enzymology, 2018, Volume: 609 Topics: Adsorption; Enzymes, Immobilized; Graphite; Nanocomposites; Oxidation-Reduction; Penicillanic Acid; Penicillin G; Polyethyleneimine; Porosity; Silicon Dioxide; Surface Properties	2018
Electric-field-enhanced selective separation of products of an enzymatic reaction in a membrane micro-contactor. Biotechnology and bioengineering, 2021, Volume: 118, Issue:2 Topics: Electricity; Lab-On-A-Chip Devices; Membranes, Artificial; Penicillanic Acid; Penicillin Amidase	2021