Page last updated: 2024-08-21

aminoimidazole carboxamide and sirolimus

aminoimidazole carboxamide has been researched along with sirolimus in 37 studies

Research

Studies (37)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	10 (27.03)	29.6817
2010's	26 (70.27)	24.3611
2020's	1 (2.70)	2.80

Authors

Authors	Studies
Bertrand, L; Hue, L; Krause, U	1
Carling, D; Cheng, SW; Fryer, LG; Shepherd, PR	1
Chan, AY; Dyck, JR; Proud, CG; Soltys, CL; Young, ME	1
Møller, MT; Samari, HR; Seglen, PO	1
Dash, PK; Moore, AN; Orsi, SA	1
Caplan, MJ; Li, J; Young, LH; Zhang, L	1
Barredo, JC; Hsieh-Kinser, TT; Leclerc, GJ; Leclerc, GM; Sengupta, TK; Singh, I	1
Borger, DR; Bucur, MC; Decaprio, JA; Gavrilescu, LC; Ivan, M	1
Cloughesy, TF; Czernin, J; Dang, J; Guo, D; Hildebrandt, IJ; Mazzotta, MM; Mischel, PS; Phelps, M; Prins, RM; Radu, CG; Shyy, JY; Soto, H; Watson, AD	1
Du, M; Tong, JF; Yan, X; Zhu, MJ	1
Akifusa, S; Fujimoto, A; Hirofuji, T; Kamio, N; Nonaka, K; Yamashita, Y	1
An, D; Feener, EP; Goodyear, LJ; Hirshman, MF; Koh, HJ; Taylor, EB; Toyoda, T; Treebak, JT; Witczak, CA; Wojtaszewski, JF; Xie, J	1
Auberger, P; Bénéteau, M; Chauvin, C; Jacquin, MA; Marchetti, S; Muñoz-Pinedo, C; Pende, M; Pradelli, LA; Ricci, JE	1
Alzamora, R; Gong, F; Hallows, KR; Li, H; Neumann, D; Pastor-Soler, NM; Scholz, R; Smolak, C; Thali, RF; Wallimann, T	1
Azzout-Marniche, D; Bos, C; Chaumontet, C; Chotechuang, N; Gaudichon, C; Tomé, D	1
Moran, RG; Racanelli, AC; Rothbart, SB	1
Arciniegas, AJ; Bowles, DE; Darrabie, MD; Jacobs, DO; Mishra, R; Santacruz, L	1
Finkensieper, A; Padmasekar, M; Sauer, H; Sharifpanah, F; Wartenberg, M	1
Foretz, M; Lantier, L; Leclerc, J; Mounier, R; Sotiropoulos, A; Viollet, B	1
Gong, YP; Gu, ZY; Hu, Y; Li, CL; Li, L; Liu, P; Liu, Y; Miao, XY; Shu, H	1
Huang, H; Kang, R; Luo, G; Wang, J; Yang, W; Zhao, Z	1
Gu, Y; Guo, SY; Huo, HZ; Liu, WY; Qin, J; Wang, B	1
Abboud, HE; Barnes, JL; Bhandary, B; Block, K; Choudhury, GG; de Cassia Cavaglieri, R; Eid, AA; Ford, BM; Gorin, Y	1
Billiar, TR; Collage, RD; Escobar, DA; Gomez, H; Howell, GM; Loughran, P; Rosengart, MR; Zhang, X; Zuckerbraun, BS	1
Abraham, E; Deshane, J; Gao, Y; Jiang, S; Park, DW; Stigler, WS; Tadie, JM; Zmijewski, JW	1
Cacciamali, A; Cocchi, D; Faggi, L; Giustina, A; Spinello, M; Tulipano, G	1
Chatterjee, A; Foster, DA; Kogan, D; Mukhopadhyay, S; Patel, D	1
Cao, N; Ding, S; Guan, KL; Li, J; Li, K; Liu, K; Ma, T; Nie, BM; Wang, H; Wei, WG; Wu, Y; Xu, S; Xu, T; Xu, Y; Yu, C; Zhu, SY	1
Dong, M; Ren, J; Ren, SY; Wang, Q; Xu, X; Zhang, Y	1
Craige, SM; Kant, S; Keaney, JF; Li, C; Reif, MM	1
Adamo, S; Aulino, P; Barone, R; Berardi, E; Carraro, U; Coletti, D; Di Felice, V; Gruppo, M; Kern, H; Li, Z; Macaluso, F; Mericskay, M; Merigliano, S; Moresi, V; Pigna, E; Rizzuto, E; Rocchi, M; Zampieri, S	1
Angelini, C; Brockhoff, M; Castets, P; Chojnowska, K; Eickhorst, C; Erne, B; Frank, S; Furling, D; Rion, N; Rüegg, MA; Sinnreich, M; Wiktorowicz, T	1
Dembitz, V; Lalic, H; Visnjic, D	1
Habib, SL; Li, B; Liang, S; Medina, EA	1
An, J; Jiang, P; Li, Y; Shen, Y; Wang, M; Zhang, J; Zhou, N	1
Belova, SP; Mirzoev, TM; Mochalova, EP; Nemirovskaya, TL; Shenkman, BS; Vilchinskaya, NA	1
Alsaqati, M; Harwood, AJ; Heine, VM	1

Reviews

1 review(s) available for aminoimidazole carboxamide and sirolimus

Article	Year
The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia. Current medicinal chemistry, 2019, Volume: 26, Issue:12 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute; Metformin; Ribonucleosides; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2019

Other Studies

36 other study(ies) available for aminoimidazole carboxamide and sirolimus

Article	Year
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes. European journal of biochemistry, 2002, Volume: 269, Issue:15 Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glutamine; Hepatocytes; Male; Marine Toxins; Multienzyme Complexes; Okadaic Acid; Oligomycins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases; Serine; Sirolimus	2002
Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. The Journal of biological chemistry, 2004, Apr-16, Volume: 279, Issue:16 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; CHO Cells; Cricetinae; Dinitrophenols; Enzyme Activation; Humans; Insulin; Mice; Multienzyme Complexes; Phosphorylation; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Ribonucleotides; Signal Transduction; Sirolimus; Threonine; TOR Serine-Threonine Kinases	2004
Activation of AMP-activated protein kinase inhibits protein synthesis associated with hypertrophy in the cardiac myocyte. The Journal of biological chemistry, 2004, Jul-30, Volume: 279, Issue:31 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Antibiotics, Antineoplastic; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Elongation Factor 2 Kinase; Enzyme Activation; Green Fluorescent Proteins; Hypertrophy; Hypoglycemic Agents; Immunoblotting; Luminescent Proteins; Metformin; Microscopy, Fluorescence; Multienzyme Complexes; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Ribose; Ribosomal Protein S6; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Time Factors	2004
Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:2 Topics: Amino Acids; Aminoimidazole Carboxamide; Androstadienes; Animals; Anti-Bacterial Agents; Antioxidants; Blotting, Western; Cell Separation; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Flavanones; Gene Expression Regulation, Enzymologic; Hepatocytes; Immunosuppressive Agents; In Vitro Techniques; Indicators and Reagents; Male; Phosphorylation; Rats; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases; Sirolimus; Toxins, Biological; Wortmannin	2004
Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006, Aug-02, Volume: 26, Issue:31 Topics: Aminoimidazole Carboxamide; Animals; Dose-Response Relationship, Drug; Drug Combinations; Glucose; Hippocampus; Maze Learning; Protein Kinases; Rats; Rats, Long-Evans; Ribonucleotides; Signal Transduction; Sirolimus; Space Perception; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins	2006
AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proceedings of the National Academy of Sciences of the United States of America, 2006, Nov-14, Volume: 103, Issue:46 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Calcium; Cell Line; Dogs; Enzyme Activation; Epithelial Cells; Multienzyme Complexes; Protein Serine-Threonine Kinases; Ribonucleotides; Sirolimus; Tight Junctions	2006
Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy. Molecular cancer, 2007, Jul-10, Volume: 6 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Cell Division; DNA Replication; Drug Delivery Systems; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Enzyme Activation; G1 Phase; Humans; Imidazoles; Leukemia-Lymphoma, Adult T-Cell; Multienzyme Complexes; Neoplasm Proteins; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prodrugs; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines; Ribonucleotides; Sirolimus; Tubercidin; Tumor Cells, Cultured	2007
AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochemical and biophysical research communications, 2008, May-30, Volume: 370, Issue:2 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Cell Hypoxia; Cell Line, Transformed; Cell Line, Tumor; Cell Survival; Humans; Protein Kinase Inhibitors; Protein Kinases; Ribonucleotides; Sirolimus; TOR Serine-Threonine Kinases	2008
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proceedings of the National Academy of Sciences of the United States of America, 2009, Aug-04, Volume: 106, Issue:31 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cell Proliferation; ErbB Receptors; Glioblastoma; Humans; Lipogenesis; Mice; Protein Kinases; PTEN Phosphohydrolase; Ribonucleotides; Ribosomal Protein S6 Kinases; Ribosomal Protein S6 Kinases, 90-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2009
AMP-activated protein kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1/Akt signaling in C2C12 myotubes. Journal of cellular biochemistry, 2009, Oct-01, Volume: 108, Issue:2 Topics: Acetyl-CoA Carboxylase; Adaptor Proteins, Signal Transducing; Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Eukaryotic Initiation Factors; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Insulin-Like Growth Factor I; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Ribonucleosides; Signal Transduction; Sirolimus; SKP Cullin F-Box Protein Ligases; TOR Serine-Threonine Kinases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases	2009
Involvement of mTOR in globular adiponectin-induced generation of reactive oxygen species. Free radical research, 2010, Volume: 44, Issue:2 Topics: Adiponectin; Aminoimidazole Carboxamide; Androstadienes; Animals; Biphenyl Compounds; Cells, Cultured; Deoxyglucose; Intracellular Signaling Peptides and Proteins; Macrophages; Mice; Nitric Oxide; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Pyrones; Reactive Oxygen Species; Ribonucleotides; Sirolimus; Structure-Activity Relationship; Thiophenes; TOR Serine-Threonine Kinases; Wortmannin	2010
Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle. American journal of physiology. Cell physiology, 2010, Volume: 298, Issue:2 Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Androstadienes; Animals; Electric Stimulation; Electroporation; Female; Gene Transfer Techniques; Glucose; GTPase-Activating Proteins; Humans; Insulin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Muscle Contraction; Muscle, Skeletal; Mutation; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Quadriceps Muscle; Recombinant Proteins; Ribonucleotides; Serine; Sirolimus; Tandem Mass Spectrometry; Time Factors; Wortmannin; Young Adult	2010
Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation. Oncogene, 2010, Mar-18, Volume: 29, Issue:11 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antibodies; Apoptosis; Blotting, Western; Deoxyglucose; Enzyme Activation; fas Receptor; Glucose; Glycolysis; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Jurkat Cells; Models, Biological; Myeloid Cell Leukemia Sequence 1 Protein; Protein Biosynthesis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyrimidines; Receptors, Death Domain; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA Interference; Sirolimus; TNF-Related Apoptosis-Inducing Ligand; TOR Serine-Threonine Kinases; U937 Cells	2010
Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. American journal of physiology. Renal physiology, 2010, Volume: 299, Issue:1 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biotinylation; Blotting, Western; Cell Line, Transformed; Cell Polarity; Creatine; Energy Metabolism; Enzyme Activation; Enzyme Activators; Epithelial Cells; Humans; Immunohistochemistry; Intracellular Signaling Peptides and Proteins; Kidney Tubules, Proximal; Kinetics; Male; Membrane Potentials; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; Oocytes; Patch-Clamp Techniques; Plasma Membrane Neurotransmitter Transport Proteins; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rats; Ribonucleotides; Sirolimus; Sodium; TOR Serine-Threonine Kinases; Xenopus laevis	2010
Down-regulation of the ubiquitin-proteasome proteolysis system by amino acids and insulin involves the adenosine monophosphate-activated protein kinase and mammalian target of rapamycin pathways in rat hepatocytes. Amino acids, 2011, Volume: 41, Issue:2 Topics: Amino Acids; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Dietary Proteins; Down-Regulation; Gene Expression Profiling; Hepatocytes; Hypoglycemic Agents; Insulin; Male; Organ Size; Phosphorylation; Postprandial Period; Proteasome Endopeptidase Complex; Rats; Rats, Wistar; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ubiquitin; Ubiquitinated Proteins; Ubiquitination	2011
Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas. Cancer research, 2010, Dec-15, Volume: 70, Issue:24 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Enzyme Activation; Enzyme Inhibitors; Glutamates; Guanine; HCT116 Cells; HeLa Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Oncogene Protein v-akt; Pemetrexed; Protein Serine-Threonine Kinases; Proteins; Ribonucleotides; Sirolimus; Thymidylate Synthase; TOR Serine-Threonine Kinases	2010
AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes. American journal of physiology. Endocrinology and metabolism, 2011, Volume: 300, Issue:5 Topics: Aminoimidazole Carboxamide; Animals; Biological Transport, Active; Blotting, Western; Cells, Cultured; Creatine; Culture Media; Cyclic AMP-Dependent Protein Kinases; DNA, Complementary; Kinetics; Membrane Proteins; Mice; Myocytes, Cardiac; Plasmids; Proto-Oncogene Proteins c-myc; Rats; Ribonucleotides; Sirolimus; TOR Serine-Threonine Kinases	2011
Stimulation of cardiomyogenesis of embryonic stem cells by nitric oxide downstream of AMP-activated protein kinase and mTOR signaling pathways. Stem cells and development, 2011, Volume: 20, Issue:12 Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Embryoid Bodies; Embryonic Stem Cells; Gene Expression Regulation; Mice; Models, Biological; Myocardium; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase; Organogenesis; Phosphorylation; Ribonucleotides; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2011
Antagonistic control of muscle cell size by AMPK and mTORC1. Cell cycle (Georgetown, Tex.), 2011, Aug-15, Volume: 10, Issue:16 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Size; Food; Gene Knockout Techniques; Humans; Hypertrophy; Mechanistic Target of Rapamycin Complex 1; Mice; Motor Activity; Multiprotein Complexes; Muscle Development; Muscles; Protein Subunits; Proteins; Ribonucleotides; Signal Transduction; Sirolimus; Starvation; TOR Serine-Threonine Kinases	2011
The human glucagon-like peptide-1 analogue liraglutide regulates pancreatic beta-cell proliferation and apoptosis via an AMPK/mTOR/P70S6K signaling pathway. Peptides, 2013, Volume: 39 Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Cell Cycle Proteins; Cell Line; Cell Proliferation; Cell Survival; Cells, Cultured; Glucagon-Like Peptide 1; Humans; Hypoglycemic Agents; Insulin-Secreting Cells; Liraglutide; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2013
Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy. Autophagy, 2013, Feb-01, Volume: 9, Issue:2 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Line, Tumor; Endoplasmic Reticulum Stress; Enzyme Activation; Gene Knockdown Techniques; Hepacivirus; Hepatitis C; Humans; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Metformin; Models, Biological; Multiprotein Complexes; Phenylbutyrates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tumor Suppressor Proteins; Virus Replication	2013
AMP-activated protein kinase (AMPK)/Ulk1-dependent autophagic pathway contributes to C6 ceramide-induced cytotoxic effects in cultured colorectal cancer HT-29 cells. Molecular and cellular biochemistry, 2013, Volume: 378, Issue:1-2 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Autophagy; Autophagy-Related Protein-1 Homolog; Cell Survival; Ceramides; Colorectal Neoplasms; Enzyme Activation; Everolimus; HCT116 Cells; HT29 Cells; Humans; Intracellular Signaling Peptides and Proteins; Protein Serine-Threonine Kinases; Ribonucleotides; Signal Transduction; Sirolimus	2013
Mammalian target of rapamycin regulates Nox4-mediated podocyte depletion in diabetic renal injury. Diabetes, 2013, Volume: 62, Issue:8 Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Apoptosis; Cell Line; Diabetic Nephropathies; Glucose; Hypoglycemic Agents; Mice; NADPH Oxidase 4; NADPH Oxidases; Phosphorylation; Podocytes; Reactive Oxygen Species; Ribonucleotides; Sirolimus; TOR Serine-Threonine Kinases	2013
Augmenting autophagy to treat acute kidney injury during endotoxemia in mice. PloS one, 2013, Volume: 8, Issue:7 Topics: Acute Kidney Injury; Aminoimidazole Carboxamide; Animals; Autophagy; Class III Phosphatidylinositol 3-Kinases; Endotoxemia; Lipopolysaccharides; Male; Mice; Protein Kinase Inhibitors; Ribonucleotides; Sirolimus; TOR Serine-Threonine Kinases	2013
Activation of AMPK enhances neutrophil chemotaxis and bacterial killing. Molecular medicine (Cambridge, Mass.), 2013, Nov-08, Volume: 19 Topics: Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bacteremia; Chemotaxis, Leukocyte; Enzyme Activation; Heterocyclic Compounds, 3-Ring; HL-60 Cells; Humans; Male; Metformin; Mice; Mice, Inbred C57BL; Neutrophils; Peritonitis; Phagocytosis; Phosphorylation; Protein Kinase Inhibitors; Pyridines; Ribonucleotides; RNA, Small Interfering; Signal Transduction; Sirolimus	2013
Role of AMP-activated protein kinase activators in antiproliferative multi-drug pituitary tumour therapies: effects of combined treatments with compounds affecting the mTOR-p70S6 kinase axis in cultured pituitary tumour cells. Journal of neuroendocrinology, 2015, Volume: 27, Issue:1 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Catalytic Domain; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Enzyme Activation; Imidazoles; Phosphorylation; Piperazines; Pituitary Neoplasms; Rats; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; TOR Serine-Threonine Kinases	2015
5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) enhances the efficacy of rapamycin in human cancer cells. Cell cycle (Georgetown, Tex.), 2015, Volume: 14, Issue:20 Topics: Aminoimidazole Carboxamide; Antibiotics, Antineoplastic; Cell Cycle Checkpoints; Cell Proliferation; Dose-Response Relationship, Drug; Drug Therapy, Combination; Humans; MCF-7 Cells; Neoplasms; Ribonucleotides; Sirolimus; Treatment Outcome	2015
Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming. Nature cell biology, 2015, Volume: 17, Issue:11 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein 5; Blotting, Western; Cells, Cultured; Cellular Reprogramming; Embryo, Mammalian; Fibroblasts; Green Fluorescent Proteins; Induced Pluripotent Stem Cells; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Electron; Microscopy, Fluorescence; Microtubule-Associated Proteins; Mitochondria; Octamer Transcription Factor-3; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleotides; RNA Interference; Sirolimus	2015
Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia. Journal of molecular and cellular cardiology, 2016, Volume: 93 Topics: Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Autophagy-Related Protein-1 Homolog; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Cell Death; Disease Models, Animal; Endotoxemia; Lipopolysaccharides; Male; Mice; Mice, Knockout; Myocarditis; Myocardium; Myocytes, Cardiac; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases; Ventricular Dysfunction	2016
Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling. Nitric oxide : biology and chemistry, 2016, 05-01, Volume: 55-56 Topics: Adaptation, Physiological; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Calcimycin; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Enzyme Activators; Humans; Hydrogen Peroxide; Mechanistic Target of Rapamycin Complex 1; Mice, Knockout; Mitochondria; Nitric Oxide Synthase Type III; Organelle Biogenesis; Oxidative Stress; Rats; Ribonucleotides; Signal Transduction; Sirolimus	2016
Aerobic Exercise and Pharmacological Treatments Counteract Cachexia by Modulating Autophagy in Colon Cancer. Scientific reports, 2016, 05-31, Volume: 6 Topics: Aminoimidazole Carboxamide; Animals; Autophagosomes; Autophagy; Cachexia; Cell Line, Tumor; Colonic Neoplasms; Female; Humans; Lysosomes; Mice; Mice, Inbred BALB C; Muscle Fibers, Skeletal; Muscle Weakness; Muscle, Skeletal; Neoplasm Transplantation; Physical Conditioning, Animal; Ribonucleotides; Sirolimus; Survival Analysis	2016
Targeting deregulated AMPK/mTORC1 pathways improves muscle function in myotonic dystrophy type I. The Journal of clinical investigation, 2017, Feb-01, Volume: 127, Issue:2 Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Humans; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Mutant Strains; Middle Aged; Multiprotein Complexes; Muscle Fibers, Skeletal; Muscle Relaxation; Myotonic Dystrophy; Myotonin-Protein Kinase; Ribonucleotides; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases	2017
Preclinical evidence of the enhanced effectiveness of combined rapamycin and AICAR in reducing kidney cancer. Molecular oncology, 2018, Volume: 12, Issue:11 Topics: Aminoimidazole Carboxamide; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Line, Tumor; Humans; Kidney Neoplasms; Male; Mice; Mice, Nude; Ribonucleotides; Sirolimus; Xenograft Model Antitumor Assays	2018
Haemophilus parasuis infection in 3D4/21 cells induces autophagy through the AMPK pathway. Cellular microbiology, 2019, Volume: 21, Issue:8 Topics: Adenine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Autophagy; Cell Line; Gene Expression Regulation; Genes, Reporter; Green Fluorescent Proteins; Haemophilus parasuis; Host-Pathogen Interactions; Luminescent Proteins; Macrophages, Alveolar; Microtubule-Associated Proteins; Oxazines; Protein Isoforms; Red Fluorescent Protein; Ribonucleotides; Signal Transduction; Sirolimus; Swine; Virulence	2019
Elevated p70S6K phosphorylation in rat soleus muscle during the early stage of unloading: Causes and consequences. Archives of biochemistry and biophysics, 2019, 10-15, Volume: 674 Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activators; Enzyme Inhibitors; Hindlimb Suspension; Histone Deacetylases; Male; Mechanistic Target of Rapamycin Complex 1; Muscle, Skeletal; Phosphorylation; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases, 70-kDa; Sirolimus; Threonine; Ubiquitin-Protein Ligases; Up-Regulation	2019
Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation. Molecular autism, 2020, 10-19, Volume: 11, Issue:1 Topics: Adolescent; Aminoimidazole Carboxamide; Autism Spectrum Disorder; Autophagy-Related Protein-1 Homolog; Biomarkers; Electrodes; Gene Expression Regulation; Humans; Induced Pluripotent Stem Cells; Infant; Intracellular Signaling Peptides and Proteins; Mechanistic Target of Rapamycin Complex 1; Mutation; Nerve Net; Neurons; Ribonucleotides; Signal Transduction; Sirolimus; Synapses; Tuberous Sclerosis Complex 2 Protein	2020