Compounds > aminoimidazole carboxamide
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aminoimidazole carboxamide and pemetrexed

aminoimidazole carboxamide has been researched along with pemetrexed in 4 studies

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's3 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cherian, C; Gangjee, A; Hales, E; Hou, Z; Matherly, LH; Mitchell-Ryan, S; Orr, S; Raghavan, S; Ravindra, MP; Wang, Y1
Heyer, CL; Moran, RG; Racanelli, AC; Rothbart, SB1
Moran, RG; Racanelli, AC; Rothbart, SB1
Agarwal, S; Bell, CM; Moran, RG; Rothbart, SB1

Other Studies

4 other study(ies) available for aminoimidazole carboxamide and pemetrexed

ArticleYear
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implic
    Journal of medicinal chemistry, 2013, Dec-27, Volume: 56, Issue:24

    Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; KB Cells; Models, Molecular; Molecular Structure; Purine Nucleotides; Pyrimidines; Pyrroles; Structure-Activity Relationship

2013
Therapeutics by cytotoxic metabolite accumulation: pemetrexed causes ZMP accumulation, AMPK activation, and mammalian target of rapamycin inhibition.
    Cancer research, 2009, Jul-01, Volume: 69, Issue:13

    Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Division; Enzyme Activation; Folic Acid Antagonists; Glutamates; Glycine; Guanine; Humans; Kinetics; Lung Neoplasms; Mesothelioma; Pemetrexed; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Protein Kinases; Ribonucleotides; TOR Serine-Threonine Kinases

2009
Pemetrexed indirectly activates the metabolic kinase AMPK in human carcinomas.
    Cancer research, 2010, Dec-15, Volume: 70, Issue:24

    Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Enzyme Activation; Enzyme Inhibitors; Glutamates; Guanine; HCT116 Cells; HeLa Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Oncogene Protein v-akt; Pemetrexed; Protein Serine-Threonine Kinases; Proteins; Ribonucleotides; Sirolimus; Thymidylate Synthase; TOR Serine-Threonine Kinases

2010
AMP-activated Protein Kinase (AMPK) Control of mTORC1 Is p53- and TSC2-independent in Pemetrexed-treated Carcinoma Cells.
    The Journal of biological chemistry, 2015, Nov-13, Volume: 290, Issue:46

    Topics: Adaptor Proteins, Signal Transducing; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Checkpoint Kinase 2; Enzyme Activation; Folic Acid Antagonists; HCT116 Cells; Humans; Mechanistic Target of Rapamycin Complex 1; Multiprotein Complexes; Pemetrexed; Phosphorylation; Regulatory-Associated Protein of mTOR; Ribonucleotides; Signal Transduction; TOR Serine-Threonine Kinases; Transcription, Genetic; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2015