aminoimidazole carboxamide has been researched along with methotrexate in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (18.18) | 18.7374 |
| 1990's | 7 (31.82) | 18.2507 |
| 2000's | 4 (18.18) | 29.6817 |
| 2010's | 6 (27.27) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Cherian, C; Gangjee, A; Hales, E; Hou, Z; Matherly, LH; Mitchell-Ryan, S; Orr, S; Raghavan, S; Ravindra, MP; Wang, Y | 1 |
| Johnson, H; Lapin, C | 1 |
| Christopherson, RI; Lyons, SD; Phillips, L; Sant, ME | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RR; De Bruyn, CH; Hulscher, TW; Schretlen, ED; van Laarhoven, JP | 1 |
| Baggott, JE; Hudson, BB; Vaughn, WH | 1 |
| Bakker, MA; Bökkerink, JP; De Abreu, RA; Hulscher, TW; Schretlen, ED | 1 |
| Conget, I; Malaisse, WJ; Rorsman, P; Sener, A | 1 |
| Cronstein, BN; Naime, D; Ostad, E | 2 |
| Baggott, JE; Koopman, WJ; Morgan, SL | 1 |
| Baggott, JE; Linden, J; Morgan, SL; Sams, WM | 1 |
| Kaznowska, Z; Simmonds, HA; Smoleńska, Z; Smoleński, RT; Zarówny, D | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA | 1 |
| Haile, WH; McGuire, JJ; Yeh, CC | 1 |
| Beckers, A; Brusselmans, K; Deboel, L; Derua, R; Organe, S; Swinnen, JV; Timmermans, L; Vanderhoydonc, F; Verhoeven, G; Waelkens, E | 1 |
| Baggott, JE; Morgan, SL | 1 |
| Barredo, JC; Kuznetsov, JN; Leclerc, GJ; Leclerc, GM | 1 |
| Cheng, XL; Li, B; Li, L; Li, MY; Li, ZQ; Lu, W; Zhou, TY | 1 |
| Becker, ML; Funk, RS; Leeder, JS; van Haandel, L | 1 |
| Ambrožič, A; Chibalin, AV; Gašperšič, N; Hočevar, A; Omersel, J; Perdan-Pirkmajer, K; Pirkmajer, S; Praprotnik, S; Rotar, Ž; Sodin-Šemrl, S; Thevis, M; Thomas, A; Tomšič, M; Žibert, J | 1 |
| Abdul-Rahman, O; Bai, P; Dér, Á; Fodor, T; Kiss, B; Nagy, L; Szántó, M | 1 |
| Aune, TM; Cronstein, BN | 1 |
1 review(s) available for aminoimidazole carboxamide and methotrexate
| Article | Year |
|---|---|
Methotrexate and its mechanisms of action in inflammatory arthritis.
Topics: Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis; Humans; Immunity, Cellular; Methotrexate; Ribonucleotides; T-Lymphocytes; Tetrahydrofolate Dehydrogenase | 2020 |
3 trial(s) available for aminoimidazole carboxamide and methotrexate
| Article | Year |
|---|---|
4-Aminoimidazole-5-carboxamide excretion in acute leukemia.
Topics: Acute Disease; Adolescent; Aminoimidazole Carboxamide; Antineoplastic Agents; Child; Child, Preschool; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Imidazoles; Infant; Leukemia; Male; Mercaptopurine; Methotrexate; Prednisone; Remission, Spontaneous; Vincristine | 1978 |
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.
Topics: Adenosine; Adenosine Triphosphate; Adult; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Chronic Disease; Cytidine Triphosphate; Erythrocytes; Female; Guanosine Triphosphate; Humans; Hypoxanthine; Methotrexate; Middle Aged; Ribonucleotides; Uric Acid; Uridine | 1999 |
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
18 other study(ies) available for aminoimidazole carboxamide and methotrexate
| Article | Year |
|---|---|
Discovery of 5-substituted pyrrolo[2,3-d]pyrimidine antifolates as dual-acting inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis: implic
Topics: AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Cell Proliferation; CHO Cells; Cricetulus; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; KB Cells; Models, Molecular; Molecular Structure; Purine Nucleotides; Pyrimidines; Pyrroles; Structure-Activity Relationship | 2013 |
Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells.
Topics: Amidophosphoribosyltransferase; Aminoimidazole Carboxamide; Animals; Azaserine; Folic Acid Antagonists; Leukemia, Experimental; Methotrexate; Methylthioinosine; Mice; Purines; Pyrimidines; Ribonucleotides; Tumor Cells, Cultured | 1992 |
Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.
Topics: Aminoimidazole Carboxamide; Cell Line; Drug Synergism; Glutamine; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia, Lymphoid; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; T-Lymphocytes | 1986 |
Inhibition of 5-aminoimidazole-4-carboxamide ribotide transformylase, adenosine deaminase and 5'-adenylate deaminase by polyglutamates of methotrexate and oxidized folates and by 5-aminoimidazole-4-carboxamide riboside and ribotide.
Topics: Acyltransferases; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; AMP Deaminase; Folic Acid; Hydroxymethyl and Formyl Transferases; Kinetics; Methotrexate; Nucleoside Deaminases; Nucleotide Deaminases; Peptides; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Polyglutamic Acid; Pteroylpolyglutamic Acids; Ribonucleotides; Spectrophotometry | 1986 |
Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages.
Topics: Aminoimidazole Carboxamide; Drug Synergism; Glycine; Humans; Hypoxanthine; Hypoxanthines; Leukemia; Lymphocytes; Mercaptopurine; Methotrexate; Phosphoribosyl Pyrophosphate; Purines; Ribonucleotides; Tumor Cells, Cultured | 1988 |
Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects.
Topics: Adenine Nucleotides; Amino Acids; Aminoimidazole Carboxamide; Animals; Calcium; Egtazic Acid; Female; Glucose; Glycolysis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Membrane Potentials; Methotrexate; Mice; Mice, Inbred Strains; Patch-Clamp Techniques; Rats; Rats, Wistar; Ribonucleosides; Rubidium; Time Factors | 1994 |
The antiinflammatory effects of methotrexate are mediated by adenosine.
Topics: Acyltransferases; Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Hydroxymethyl and Formyl Transferases; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purinergic P1 Receptor Antagonists; Ribonucleotides; Theobromine; Xanthines | 1994 |
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation.
Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Female; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Antagonists; Ribonucleotides; Spleen; Theobromine; Time Factors | 1993 |
The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion.
Topics: Aminoimidazole Carboxamide; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Hindlimb; Hydroxymethyl and Formyl Transferases; Joints; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Rats; Rats, Inbred Lew | 1998 |
Urinary adenosine and aminoimidazolecarboxamide excretion in methotrexate-treated patients with psoriasis.
Topics: Adenosine; Adult; Aged; Aminoimidazole Carboxamide; Female; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Middle Aged; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Psoriasis; Ribonucleotides | 1999 |
5-amino-4-imidazolecarboxamide riboside potentiates both transport of reduced folates and antifolates by the human reduced folate carrier and their subsequent metabolism.
Topics: Aminoimidazole Carboxamide; Biological Transport; Cell Line, Tumor; Child; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid Antagonists; Humans; Kinetics; Leukemia, T-Cell; Membrane Transport Proteins; Methotrexate; Phosphoribosylglycinamide Formyltransferase; Polyglutamic Acid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reduced Folate Carrier Protein; Ribonucleotides; Subcellular Fractions; Temperature; Thymidylate Synthase; Tritium | 2006 |
Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA, Neoplasm; Drug Synergism; Enzyme Activation; Humans; Lipids; Methotrexate; Multienzyme Complexes; Nucleotide Deaminases; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Protein Serine-Threonine Kinases; Purines; Ribonucleosides; Ribonucleotides; RNA Interference | 2006 |
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Rats; Ribonucleosides | 2007 |
AMPK and Akt determine apoptotic cell death following perturbations of one-carbon metabolism by regulating ER stress in acute lymphoblastic leukemia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Apoptosis; Carbon; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Endoplasmic Reticulum; Humans; Methotrexate; Molecular Targeted Therapy; Phosphorylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Proto-Oncogene Proteins c-akt; Ribonucleotides; Signal Transduction | 2011 |
Methotrexate and 5-aminoimidazole-4-carboxamide riboside exert synergistic anticancer action against human breast cancer and hepatocellular carcinoma.
Topics: Aminoimidazole Carboxamide; Animals; Apoptosis; Breast Neoplasms; Carcinoma, Hepatocellular; Cell Proliferation; Drug Synergism; Female; Hep G2 Cells; Humans; Liver Neoplasms, Experimental; MCF-7 Cells; Methotrexate; Mice; Mice, Inbred BALB C; Mice, Nude; Xenograft Model Antitumor Assays | 2013 |
Low-dose methotrexate results in the selective accumulation of aminoimidazole carboxamide ribotide in an erythroblastoid cell line.
Topics: Aminoimidazole Carboxamide; Dose-Response Relationship, Drug; Erythroblasts; Folic Acid Antagonists; Humans; K562 Cells; Methotrexate; Ribonucleotides | 2013 |
Methotrexate reduces HbA1c concentration but does not produce chronic accumulation of ZMP in patients with rheumatoid or psoriatic arthritis.
Topics: Adult; Aged; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Glucose; Chromatography, Liquid; Erythrocytes; Female; Glycated Hemoglobin; Humans; Insulin; Insulin Resistance; Male; Methotrexate; Middle Aged; Prospective Studies; Ribonucleotides; Tandem Mass Spectrometry | 2016 |
Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cell Cycle; Cell Division; Cell Line, Tumor; Cytostatic Agents; Drug Screening Assays, Antitumor; Drug Synergism; Energy Metabolism; Enzyme Induction; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; Glycolysis; Humans; Lactates; MCF-7 Cells; Membrane Potential, Mitochondrial; Methotrexate; Molecular Targeted Therapy; Neoplasm Proteins; Osteosarcoma; Ribonucleotides; RNA Interference; Transcription Factors | 2016 |