Page last updated: 2024-08-21

aminoimidazole carboxamide and adenosine

aminoimidazole carboxamide has been researched along with adenosine in 106 studies

Research

Studies (106)

Timeframe	Studies, this research(%)	All Research%
pre-1990	13 (12.26)	18.7374
1990's	48 (45.28)	18.2507
2000's	28 (26.42)	29.6817
2010's	16 (15.09)	24.3611
2020's	1 (0.94)	2.80

Authors

Authors	Studies
Ekblom, P; Lash, JW; Lehtonen, E; Nordling, S; Saxén, L	1
Casaer, P; Jaeken, J; Van den Bergh, F; Van den Berghe, G; Vincent, MF	1
Kaminski, PM; Proctor, KG	1
Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM	1
Barankiewicz, J; Gruber, HE; Jimenez, R; Magill, M; Ronlov, G	1
Barankiewicz, J; Gruber, HE; Jimenez, R; Uyesaka, J	1
Burrier, AC; Jeng, AY; Oei, HH	1
Cristalli, G; Eleuteri, A; Franchetti, P; Grifantini, M; Lupidi, G; Vittori, S	1
Matthews, RG; Rohlman, CE	1
Engler, RL; Gruber, HE; Hoffer, ME; Laikind, PK; Lane, TA; McAllister, DR; Schmid-Schoenbein, GW	1
Van den Berghe, G; Vincent, MF	1
Gruber, HE; Marquardt, DL	1
Boss, GR	1
de Bree, PK; Duran, M; Fabery de Jonge, H; Wadman, SK	1
de Bree, PK; de Jonge, HF; Duran, M; Wadman, SK	1
Gruber, HE; Laikind, PK; Seegmiller, JE	1
Hoffmeister, HM; Mauser, M; Nienaber, C; Schaper, W	1
Horgan, CM; Tisdale, MJ	1
Jaeken, J; Van den Berghe, G	1
Al-Safi, SA; Maddocks, JL	1
Pasque, MK; Wechsler, AS	1
Eglen, RM; Flippin, LA; Kim, EJ; Lazar, DA; Leung, E; Seran, CS; Walsh, LK; Wong, EH	1
Bullough, D; Mullane, K	1
Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM; Zhai, X	1
Burckhartt, B; Cohen, MV; Downey, JM; Mullane, KM; Tsuchida, A; Yang, XM	2
Bullough, DA; Firestein, GS; Magill, MJ; Mullane, KM	1
Cronstein, BN; Naime, D; Ostad, E	2
Gruber, HE	1
Hudspeth, DA; McGee, DS; Sato, H; Van Wylen, DG; Vinten-Johansen, J; Williams, MW; Zhao, ZQ	1
Auszura, LA; Davis, E; Mathew, JP; O'Connor, T; Rinder, CS; Smith, BR; Tracey, JB	1
Davisson, VJ; Firestine, SM	1
Bullough, DA; Montag, A; Mullane, KM; Young, MA; Zhang, C	1
Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Morioka, T; Node, K; Sato, H; Takashima, S	1
Dai, HB; Friedman, M; Johnson, RG; Piana, RN; Sellke, FW; Wang, SY	1
Engler, RL	1
Barner, HB; Gatell, JA; Shevde, K	1
Downey, JM; Liu, GS; Mullane, K; Tsuchida, A	1
Mullane, K	1
Gathof, BS; Gresser, U; Gross, M; Kölle, P	1
Buckley, MT; Carlin, G; Cronstein, BN; Gadangi, P; Levin, RI; Longaker, M; Montesinos, MC; Naime, D; Recht, PA	1
Fabian, MJ; Fabian, TC; Proctor, KG; Yockey, JM	1
White, TD	1
Buggé, CJ; Bullough, DA; Kurz, MA; Mullane, KM; Young, MA	1
Cheng, TO	1
Bouma, MG; Buurman, WA; van den Wildenberg, FA	1
Bosschaart, AN; Duran, M; Hageman, G; Tien Poll-The, B; van den Bergh, FA	1
Duley, JA; Simmonds, HA; Stone, TW; van den Berghe, G; Vincent, MF	1
Behan, WM; Duley, JA; Jones, PA; Morris, BJ; Ogilvy, HA; Roberts, LA; Simmonds, HA; Stone, TW; van den Berghe, G; Vincent, MF	1
Samari, HR; Seglen, PO	1
Bache, RJ; Duncker, DJ; Ishibashi, Y; Klassen, C; Quebbeman, BB	1
Lee, HT	1
Richardt, G; Schreieck, J	1
Unkle, DW	1
Baggott, JE; Linden, J; Morgan, SL; Sams, WM	1
Hori, M; Kitakaze, M; Kuzuya, T; Minamino, T; Mori, H; Node, K; Shinozaki, Y; Takashima, S	1
Kaznowska, Z; Simmonds, HA; Smoleńska, Z; Smoleński, RT; Zarówny, D	1
Hegge, JO; Lasley, RD; Mentzer , RM; Randhawa, MP	1
Chrastina, P; Hansíková, H; Houstek, J; Kmoch, S; Krijt, J; Stratilová, L; Wenchich, L; Zeman, J	1
Davis, KA; Fabian, TC; Proctor, KG; Ragsdale, DN; Trenthem, LL	1
Proctor, KG; Ragsdale, DN	1
Sakakibara, H; Sugiyama, T; Takei, K; Taniguchi, M	1
Winter, D; Zubay, G	1
Marie, S; Race, V; Van den Berghe, G; Vincent, MF	1
Downs, SM; Hardie, DG; Hudson, ER	1
Carling, D; Fryer, LG; Parbu-Patel, A	1
Campàs, C; Gil, J; López, JM; Santidrián, AF	1
Barragán, M; Bellosillo, B; Campàs, C; Colomer, D; Gil, J; Lopez, JM; Santidrián, AF	1
Currie, AJ; Dale, N; Frenguelli, BG; Gadalla, AE; Hardie, DG; Hawley, SA; Hirst, W; Michel, AD; Pearson, T; Randall, A; Sheehan, M	1
Baik, HH; Cho, YH; Ha, J; Jhun, BS; Jin, Q; Kang, I; Kim, SS; Kong, Y; Oh, YT	1
Nagai, K; Nakagawa, K; Nishizaki, T; Saitoh, M; Yamamoto, S; Yamamura, T	1
Chavin, K; Lin, A; Orak, J; Sekhon, B; Sekhon, C; Singh, A; Singh, I; Smith, A	1
Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA	1
Champion, M; Duley, JA; Fairbanks, LD; Kurian, MA; Marie, S; Marinaki, AM; Simmonds, HA; van den Berghe, G; Vincent, MF	1
Glaser, R; Qian, M	1
Hartmannová, H; Kmoch, S; Krijt, J; Zikánová, M	1
Chang, AS; Chen, J; Chi, MM; Downs, SM; Hardie, DG; Hudson, E; Moley, KH	1
Dietzel, C; Mangano, DT; Miao, Y; Tudor, IC	1
Kloner, RA	1
Bartrons, R; Ben Mosbah, I; Boillot, O; Fernández-Monteiro, I; Massip-Salcedo, M; Peralta, C; Roselló-Catafau, J; Xaus, C	1
Baggott, JE; Morgan, SL	1
Bullinger, D; Fehm, T; Gleiter, CH; Kammerer, B; Laufer, S; Neubauer, H	1
De Vries, GW; Ni, M; Qin, S	1
Grajkowska, W; Jurkiewicz, E; Kuśmierska, K; Lewandowska, E; Mierzewska, H; Rafałowska, J; Schmidt-Sidor, B; Stepień, T	1
Jurecka, A; Kmoch, S; Krijt, J; Tylki-Szymanska, A; Zikanova, M	1
Drew, BG; Kingwell, BA	1
Bahi-Buisson, N; Benoist, JF; Ceballos-Picot, I; Desguerre, I; Gitiaux, C; Marie, S; Rio, M; Valayannopoulos, V; Verrieres, S; Vincent, MF	1
Hale, SL; Kloner, RA	1
Chen, BC; Duley, JA; Khoo, TB; McGown, IN; Ngu, LH; Pitt, J; Thong, MK; Yunus, ZM	1
Cook, MA; Karmazyn, M; Pang, T; Rajapurohitam, V	1
Cigorraga, SB; Denduchis, B; Galardo, MN; Lustig, L; Meroni, SB; Pellizzari, EH; Riera, MF; Scarcelli, R; Sobarzo, C	1
Nakano, T; Nishizaki, T; Yaguchi, T; Yang, D	1
Bumpus, NN; Johnson, EF	1
Ambrosio, G; Ferguson, TB; Harrington, RA; Koglin, J; Lira, A; Newman, MF; Nussmeier, NA; Pearl, RG; Pitt, B; Reece, TL; Wechsler, AS; Weisel, RD; White, JA	1
Barker, PB; De Boer, L; Engelke, U; Fahrner, JA; Horská, A; Lin, DD; Maegawa, GH; Marie, S; Morava, E; Van der Graaf, M; Vining, E; Wevers, RA; Willemsen, MA; Zulfiqar, M	1
Duval, N; Ghosh, K; Patterson, D; Ray, SP; Shaheen, SE; Wilkinson, TG	1
Gupta, RC; Kohli, S; Lanfear, DE; Rastogi, S; Sabbah, HN; Wang, M; Zhang, K	1
Adamkova, V; Cermakova, R; Jurecka, A; Kmoch, S; Krijt, J; Skopova, V; Zikanova, M	1
Baresova, V; Kmoch, S; Krijt, J; Krijt, M; Skopova, V; Zikanova, M	1
Chen, B; Li, J; Zhu, H	1
Forrest, JN; Menendez, DM; Neuman, RI; Pfau, DJ; van Kalmthout, JAM; Young, LH	1
Chibalin, AV; Dolinar, K; Jan, V; Pavlin, M; Pirkmajer, S	1
Beedle, AM; Bissa, B; Govindarajan, R; Kaddoumi, A; McElroy, C; Muruganandan, S; Nair, S; Pathak, R; Persaud, AK; Raj, R; Sparreboom, A; Strohecker, AM; Williams, M	1
Barbisan, PRT; Efstathiou, NE; Georgakopoulos, CD; Konstantinou, EK; Maidana, DE; Miller, JW; Moustafa, GA; Notomi, S; Vavvas, DG	1

Reviews

9 review(s) available for aminoimidazole carboxamide and adenosine

Article	Year
Metabolic intervention to affect myocardial recovery following ischemia. Annals of surgery, 1984, Volume: 200, Issue:1 Topics: Adenine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Citric Acid Cycle; Coronary Circulation; Coronary Disease; Fructosediphosphates; Glucose; Glycogen; Heart; Humans; Inosine; Myocardium; Oxidative Phosphorylation; Ribonucleosides; Ribose	1984
Harnessing an endogenous cardioprotective mechanism: cellular sources and sites of action of adenosine. Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Carrier Proteins; Dogs; Endothelium, Vascular; Energy Metabolism; Guinea Pigs; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Rats; Receptors, Purinergic P1; Reperfusion Injury; Ribonucleosides; Signal Transduction	1995
Acadesine: preclinical overview. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Vessels; Dogs; Heart; Heart Transplantation; Muscle, Smooth, Vascular; Myocardial Stunning; Rats; Ribonucleosides	1994
Harnessing nature's own cardiac defense mechanism with acadesine, an adenosine regulating agent: importance of the endothelium. Journal of cardiac surgery, 1994, Volume: 9, Issue:3 Suppl Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Endothelium, Vascular; Heart; Humans; Myocardial Reperfusion Injury; Myocardial Stunning; Ribonucleosides	1994
Adenosine and myocardial protection. Journal of cardiothoracic and vascular anesthesia, 1993, Volume: 7, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Coronary Artery Bypass; Humans; Myocardial Reperfusion Injury; Ribonucleotides	1993
Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury. Cardiovascular research, 1993, Volume: 27, Issue:1 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Dogs; Guinea Pigs; Humans; Myocardial Reperfusion Injury; Myocardium; Rats; Ribonucleosides	1993
The anti-inflammatory potential of adenosine in ischemia-reperfusion injury: established and putative beneficial actions of a retaliatory metabolite. Shock (Augusta, Ga.), 1997, Volume: 8, Issue:5 Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Enzyme Inhibitors; Humans; Ischemic Preconditioning; Nucleosides; Receptors, Purinergic P1; Reperfusion Injury; Ribonucleosides	1997
Mechanisms of ischemic preconditioning and clinical implications for multiorgan ischemic-reperfusion injury. Journal of cardiothoracic and vascular anesthesia, 1999, Volume: 13, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Anesthesia; Animals; Humans; Ischemic Preconditioning; Liver; Reperfusion Injury; Ribonucleosides; Surgical Procedures, Operative; Thoracic Surgical Procedures	1999
Acadesine, an adenosine-regulating agent with the potential for widespread indications. Expert opinion on pharmacotherapy, 2008, Volume: 9, Issue:12 Topics: Adenosine; Aminoimidazole Carboxamide; Coronary Artery Bypass; Diabetes Mellitus; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Myocardial Reperfusion Injury; Ribonucleosides	2008

Trials

6 trial(s) available for aminoimidazole carboxamide and adenosine

Article	Year
Effects of acadesine on the incidence of myocardial infarction and adverse cardiac outcomes after coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group. Anesthesiology, 1995, Volume: 83, Issue:4 Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Female; Hemodynamics; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Ribonucleosides; Ventricular Function, Left	1995
Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass. The Journal of thoracic and cardiovascular surgery, 1995, Volume: 109, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Cardiopulmonary Bypass; CD18 Antigens; Female; Humans; Macrophage-1 Antigen; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Cytoadhesin; Ribonucleosides; Up-Regulation	1995
Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis. Rheumatology (Oxford, England), 1999, Volume: 38, Issue:10 Topics: Adenosine; Adenosine Triphosphate; Adult; Aminoimidazole Carboxamide; Antirheumatic Agents; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Chronic Disease; Cytidine Triphosphate; Erythrocytes; Female; Guanosine Triphosphate; Humans; Hypoxanthine; Methotrexate; Middle Aged; Ribonucleotides; Uric Acid; Uridine	1999
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis. Arthritis and rheumatism, 2004, Volume: 50, Issue:10 Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12	2004
Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine. Journal of the American College of Cardiology, 2006, Jul-04, Volume: 48, Issue:1 Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Preoperative Care; Ribonucleosides; Risk Factors; Survival Rate	2006
Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial. JAMA, 2012, Jul-11, Volume: 308, Issue:2 Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Perioperative Period; Reperfusion Injury; Ribonucleosides; Stroke; Ventricular Dysfunction, Left	2012

Other Studies

91 other study(ies) available for aminoimidazole carboxamide and adenosine

Article	Year
Inhibition of morphogenetic cell interactions by 6-diazo-5-oxo-norleucine (DON). Experimental cell research, 1979, Volume: 121, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Azo Compounds; Cell Communication; Cell Differentiation; Diazooxonorleucine; Embryonic Induction; Glucosamine; Glutamine; Guanosine; Kidney Tubules; Mice; Morphogenesis; Organ Culture Techniques	1979
Adenylosuccinase deficiency: a newly recognized variant. Journal of inherited metabolic disease, 1992, Volume: 15, Issue:3 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Child; Chromatography, High Pressure Liquid; Female; Fibroblasts; Humans; Ribonucleosides	1992
Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine. Circulation research, 1992, Volume: 71, Issue:3 Topics: 2-Chloroadenosine; Adenosine; Aminoimidazole Carboxamide; Animals; Dipyridamole; Intestines; Male; Purinergic Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reperfusion Injury; Ribonucleosides; Theophylline	1992
Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart. Circulation, 1992, Volume: 86, Issue:2 Topics: Abdomen; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Heart Transplantation; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Potassium Chloride; Rats; Rats, Inbred Lew; Ribonucleosides; Sodium Chloride; Time Factors; Transplantation, Heterotopic	1992
Alteration of purine metabolism by AICA-riboside in human B lymphoblasts. Archives of biochemistry and biophysics, 1990, Nov-01, Volume: 282, Issue:2 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; B-Lymphocytes; Cell Division; Cell Line; Humans; Phosphoribosyl Pyrophosphate; Purines; Ribonucleosides; Ribosemonophosphates	1990
Regulation of adenosine concentrations by acadesine (AICA-riboside) in human B-lymphoblasts. Advances in experimental medicine and biology, 1991, Volume: 309A Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; B-Lymphocytes; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Kinetics; Ribonucleosides	1991
5-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart. European journal of pharmacology, 1991, Oct-29, Volume: 204, Issue:1 Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Cardiac Output; Coronary Circulation; Heart; Hypoxia; Inosine; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Ribonucleosides	1991
Adenosine deaminase inhibitors: synthesis and structure-activity relationships of imidazole analogues of erythro-9-(2-hydroxy-3-nonyl)adenine. Journal of medicinal chemistry, 1991, Volume: 34, Issue:3 Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Intestines; Molecular Structure; Structure-Activity Relationship; Tubercidin	1991
Role of purine biosynthetic intermediates in response to folate stress in Escherichia coli. Journal of bacteriology, 1990, Volume: 172, Issue:12 Topics: Adenosine; Aminoimidazole Carboxamide; Bacterial Proteins; Cell Survival; Electrophoresis, Gel, Two-Dimensional; Escherichia coli; Folic Acid; Hemostasis; Inosine; Microbial Sensitivity Tests; Purines; Ribonucleotides; Sulfathiazole; Sulfathiazoles; Trimethoprim	1990
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury. Circulation, 1989, Volume: 80, Issue:5 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Collateral Circulation; Coronary Circulation; Dogs; Granulocytes; Imidazoles; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Ribonucleosides; Superoxides	1989
Influence of succinylpurines on the binding of adenosine to a particulate fraction of rat cerebral cortex. Advances in experimental medicine and biology, 1989, Volume: 253B Topics: Adenosine; Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Cell Membrane; Cerebral Cortex; Imidazoles; Rats; Receptors, Purinergic; Ribonucleotides	1989
Inhibition of mast cell mediator release by 5-amino-4-imidazolecarboxamide riboside. Advances in experimental medicine and biology, 1986, Volume: 195 Pt B Topics: Adenosine; Aminoimidazole Carboxamide; Animals; beta-N-Acetylhexosaminidases; Bone Marrow Cells; Calcimycin; Imidazoles; In Vitro Techniques; Mast Cells; Mice; Ribonucleotides	1986
Purine deoxynucleosides and adenosine dialdehyde decrease 5-amino-4-imidazolecarboxamide (Z-base)-dependent purine nucleotide synthesis in cultured T and B lymphoblasts. The Biochemical journal, 1987, Mar-01, Volume: 242, Issue:2 Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; B-Lymphocytes; Cell Line; Folic Acid; Humans; Imidazoles; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases; Purine Nucleosides; Purine Nucleotides; Purine-Nucleoside Phosphorylase; Purines; T-Lymphocytes	1987
Diagnosis of inherited adenylosuccinase deficiency by thin-layer chromatography of urinary imidazoles and by automated cation exchange column chromatography of purines. Clinica chimica acta; international journal of clinical chemistry, 1986, May-15, Volume: 156, Issue:3 Topics: Adenosine; Adenylosuccinate Lyase; Adolescent; Aminoimidazole Carboxamide; Autoanalysis; Child; Chromatography, Ion Exchange; Chromatography, Thin Layer; Erythrocytes; Female; Humans; Imidazoles; Infant; Lyases; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribonucleosides; Uric Acid	1986
Detection of inherited adenylosuccinase deficiency by two dimensional thin layer chromatography of urinary imidazoles. Advances in experimental medicine and biology, 1986, Volume: 195 Pt A Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Child; Chromatography, Thin Layer; Female; Humans; Infant; Infant, Newborn; Lyases; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleosides	1986
Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity. Analytical biochemistry, 1986, Volume: 156, Issue:1 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Chromatography, High Pressure Liquid; Creatinine; Ethylenediamines; Humans; Imidazoles; Lyases; Purine-Pyrimidine Metabolism, Inborn Errors; Reagent Strips; Ribonucleosides; Ribonucleotides; Spectrophotometry	1986
Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog. Circulation research, 1985, Volume: 56, Issue:2 Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Biopsy, Needle; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Female; Heart; Hemodynamics; Imidazoles; Male; Myocardium; Perfusion; Ribonucleosides; Ribose; Time Factors	1985
Antitumour imidazotetrazines--IV. An investigation into the mechanism of antitumour activity of a novel and potent antitumour agent, mitozolomide (CCRG 81010, M & B 39565; NSC 353451). Biochemical pharmacology, 1984, Jul-15, Volume: 33, Issue:14 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Carmustine; Cells, Cultured; Chymotrypsin; DNA, Neoplasm; gamma-Glutamyltransferase; Glutathione Reductase; Imidazoles; Lymphoma; Mice; Nitrogen Mustard Compounds; Thymidine; Uridine	1984
An infantile autistic syndrome characterised by the presence of succinylpurines in body fluids. Lancet (London, England), 1984, Nov-10, Volume: 2, Issue:8411 Topics: Adenosine; Aminoimidazole Carboxamide; Autistic Disorder; Body Fluids; Child, Preschool; Chromatography, Ion Exchange; Female; Humans; Hydrolysis; Infant; Male; Psychomotor Disorders; Purines; Ribonucleosides; Spectrophotometry, Ultraviolet; Succinates	1984
Azathioprine and 6-mercaptopurine (6-MP) suppress the human mixed lymphocyte reaction (MLR) by different mechanisms. British journal of clinical pharmacology, 1984, Volume: 17, Issue:4 Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Azathioprine; DNA; Guanine; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Lymphocyte Culture Test, Mixed; Lymphocytes; Mercaptopurine; Xanthine; Xanthines	1984
Enhancement of adenosine A1 receptor functions by benzoylthiophenes in guinea pig tissues in vitro. Naunyn-Schmiedeberg's archives of pharmacology, 1995, Volume: 352, Issue:2 Topics: Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Electric Stimulation; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Contraction; Myocardial Contraction; Peptides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Ribonucleosides; Thienopyridines; Thiophenes; Wasp Venoms	1995
Protection against injury during ischemia and reperfusion by acadesine derivatives GP-1-468 and GP-1-668. Studies in the transplanted rat heart. The Journal of thoracic and cardiovascular surgery, 1995, Volume: 110, Issue:3 Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Heart Transplantation; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Inbred Lew; Ribonucleosides; Ribonucleotides; Ventricular Pressure	1995
Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits. Cardiovascular research, 1995, Volume: 29, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Time Factors; Ventricular Fibrillation	1995
Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes. Journal of immunology (Baltimore, Md. : 1950), 1995, Sep-01, Volume: 155, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Cell Adhesion; Cells, Cultured; Dogs; Heart Injuries; Myocardium; Neutrophils; Receptors, Purinergic P1; Ribonucleosides	1995
The antiinflammatory effects of methotrexate are mediated by adenosine. Advances in experimental medicine and biology, 1994, Volume: 370 Topics: Acyltransferases; Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Hydroxymethyl and Formyl Transferases; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purinergic P1 Receptor Antagonists; Ribonucleotides; Theobromine; Xanthines	1994
Acadesine reduces myocardial infarct size by an adenosine mediated mechanism. Cardiovascular research, 1995, Volume: 29, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Extracellular Space; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Rabbits; Receptors, Purinergic P1; Regional Blood Flow; Ribonucleosides; Theophylline	1995
Carboxylases in de novo purine biosynthesis. Characterization of the Gallus gallus bifunctional enzyme. Biochemistry, 1994, Oct-04, Volume: 33, Issue:39 Topics: Adenosine; Affinity Labels; Amino Acid Sequence; Aminoimidazole Carboxamide; Animals; Base Sequence; Carboxy-Lyases; Cations, Divalent; Chickens; Escherichia coli; Kinetics; Magnesium Chloride; Molecular Sequence Data; Multienzyme Complexes; Peptide Synthases; Purines; Recombinant Proteins; Ribonucleotides; Sequence Analysis; Sequence Homology, Amino Acid	1994
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo. The Journal of clinical investigation, 1994, Volume: 94, Issue:4 Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Blood Physiological Phenomena; Coronary Thrombosis; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Erythrocytes; Humans; Male; Plasma; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Regional Blood Flow; Ribonucleosides; Theophylline; Tubercidin	1994
AICA riboside improves myocardial ischemia in coronary microembolization in dogs. The American journal of physiology, 1994, Volume: 267, Issue:4 Pt 2 Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Cytosol; Dogs; Energy Metabolism; Myocardial Ischemia; Myocardium; Oxygen Consumption; Ribonucleosides; Thromboembolism	1994
Adenosine and AICA-riboside fail to enhance microvascular endothelial preservation. The Annals of thoracic surgery, 1994, Volume: 58, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Blood; Bradykinin; Calcimycin; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Vessels; Endothelium, Vascular; Female; Heart Arrest, Induced; Male; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; Nitroprusside; Ribonucleosides; Swine	1994
Acadesine extends the window of protection afforded by ischaemic preconditioning. Cardiovascular research, 1994, Volume: 28, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Theophylline; Time Factors	1994
The antiinflammatory mechanism of methotrexate. Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation. The Journal of clinical investigation, 1993, Volume: 92, Issue:6 Topics: Adenosine; Adenosine Deaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Female; Inflammation; Kinetics; Leukocytes; Methotrexate; Mice; Mice, Inbred BALB C; Purinergic P1 Receptor Antagonists; Ribonucleotides; Spleen; Theobromine; Time Factors	1993
Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning. Cardiovascular research, 1993, Volume: 27, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Rabbits; Receptors, Purinergic; Ribonucleosides; Time Factors	1993
Capillary electrophoresis for screening of adenylosuccinate lyase deficiency. Electrophoresis, 1995, Volume: 16, Issue:10 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Body Fluids; Electrophoresis, Capillary; Humans; Ribonucleosides; Spectrophotometry, Ultraviolet	1995
The anti-inflammatory mechanism of sulfasalazine is related to adenosine release at inflamed sites. Journal of immunology (Baltimore, Md. : 1950), 1996, Mar-01, Volume: 156, Issue:5 Topics: Acyltransferases; Adenosine; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Disease Models, Animal; Endothelium, Vascular; Female; Humans; Hydroxymethyl and Formyl Transferases; Mice; Mice, Inbred BALB C; Neutrophil Activation; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Ribonucleotides; Sulfasalazine	1996
Acadesine and lipopolysaccharide-evoked pulmonary dysfunction after resuscitation from traumatic shock. Surgery, 1996, Volume: 119, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Capillary Permeability; Hydrocortisone; Leukocyte Count; Lipopolysaccharides; Lung; Resuscitation; Ribonucleosides; Shock, Traumatic; Swine; Tumor Necrosis Factor-alpha	1996
Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine. European journal of pharmacology, 1996, May-06, Volume: 303, Issue:1-2 Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoimidazole Carboxamide; Animals; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Ribonucleosides	1996
Cardioprotection with a novel adenosine regulating agent mediated by intravascular adenosine. European journal of pharmacology, 1997, Mar-19, Volume: 322, Issue:2-3 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Cardiotonic Agents; Deoxyribonucleosides; Female; Hemodynamics; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Swine; Swine, Miniature	1997
Adenosine and K(+)-induced Ca2+ loading. The Annals of thoracic surgery, 1997, Volume: 64, Issue:2 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Calcium; Cardioplegic Solutions; Humans; Myocardial Reperfusion Injury; Myocardium; Potassium; Ribonucleosides	1997
Adenylosuccinase deficiency with neonatal onset severe epileptic seizures and sudden death. Neuropediatrics, 1998, Volume: 29, Issue:1 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Anticonvulsants; Death, Sudden; Epilepsy; Humans; Infant, Newborn; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides	1998
Succinylpurines do not modify glutamate or adenosine effects in the CNS. Advances in experimental medicine and biology, 1998, Volume: 431 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Evoked Potentials; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Kainic Acid; Rats; Ribonucleosides; Synaptic Transmission	1998
Succinylpurines induce neuronal damage in the rat brain. Advances in experimental medicine and biology, 1998, Volume: 431 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Brain; Hippocampus; Neurons; Pyramidal Cells; Rats; Ribonucleosides	1998
Inhibition of hepatocytic autophagy by adenosine, aminoimidazole-4-carboxamide riboside, and N6-mercaptopurine riboside. Evidence for involvement of amp-activated protein kinase. The Journal of biological chemistry, 1998, Sep-11, Volume: 273, Issue:37 Topics: Acetates; Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antimetabolites; Autophagy; Cells, Cultured; Cholesterol; Drug Synergism; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Kinetics; Liver; Lovastatin; Male; Multienzyme Complexes; Nucleosides; Nucleotides; Pentostatin; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Simvastatin; Thioinosine; Tubercidin	1998
Acadesine increases blood flow in the collateralized heart during exercise. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Collateral Circulation; Coronary Circulation; Dogs; Female; Heart; Hemodynamics; Infusions, Intravenous; Male; Myocardial Ischemia; Physical Conditioning, Animal; Ribonucleosides	1998
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:1 Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines	1999
The unorthodox and orthodox: the therapeutic role of acadesine after traumatic injury and sepsis. Critical care medicine, 1999, Volume: 27, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Hemodynamics; Humans; Microcirculation; Ribonucleosides; Sepsis; Shock, Hemorrhagic; Swine; Wounds and Injuries	1999
Urinary adenosine and aminoimidazolecarboxamide excretion in methotrexate-treated patients with psoriasis. Archives of dermatology, 1999, Volume: 135, Issue:7 Topics: Adenosine; Adult; Aged; Aminoimidazole Carboxamide; Female; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Middle Aged; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Psoriasis; Ribonucleotides	1999
Improvement by 5-amino-4-imidazole carboxamide riboside of the contractile dysfunction that follows brief periods of ischemia through increases in ecto-5-nucleotidase activity and adenosine release in canine hearts. Japanese circulation journal, 1999, Volume: 63, Issue:7 Topics: 5'-Nucleotidase; Adenosine; Aminoimidazole Carboxamide; Animals; Dogs; Hemodynamics; Myocardial Contraction; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Antagonists; Reperfusion; Ribonucleosides	1999
Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig. Canadian journal of physiology and pharmacology, 1999, Volume: 77, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Extracellular Space; Female; Heart; Male; Myocardial Stunning; Perfusion; Renal Dialysis; Ribonucleosides; Swine	1999
Abnormalities in succinylpurines in fumarase deficiency: possible role in pathogenesis of CNS impairment. Journal of inherited metabolic disease, 2000, Volume: 23, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; Central Nervous System Diseases; Female; Fumarate Hydratase; Fumarates; Humans; Infant; Purines; Ribonucleosides	2000
Endogenous adenosine and secondary injury after chest trauma. The Journal of trauma, 2000, Volume: 49, Issue:5 Topics: Acidosis; Adenosine; Aminoimidazole Carboxamide; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypercapnia; Inflammation; Leukocyte Count; Peroxidase; Ribonucleosides; Survival Analysis; Swine; Thoracic Injuries; Wounds, Nonpenetrating	2000
Acadesine and intestinal barrier function after hemorrhagic shock and resuscitation. Critical care medicine, 2000, Volume: 28, Issue:12 Topics: Adenosine; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Blood Flow Velocity; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fluid Therapy; Formycins; Ileum; Intestinal Mucosa; Ischemia; Laser-Doppler Flowmetry; Male; Resuscitation; Ribonucleosides; Shock, Hemorrhagic; Swine	2000
Nitrogen-dependent accumulation of cytokinins in root and the translocation to leaf: implication of cytokinin species that induces gene expression of maize response regulator. Plant & cell physiology, 2001, Volume: 42, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Aminoimidazole Carboxamide; Blotting, Northern; Chromatography, Liquid; Cytokinins; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Plant; In Vitro Techniques; Isopentenyladenosine; Mass Spectrometry; Models, Biological; Nitrates; Nitrogen; Plant Leaves; Plant Roots; Plant Stems; Ribonucleotides; Time Factors; Zea mays; Zeatin	2001
Binding of adenine and adenine-related compounds to the clay montmorillonite and the mineral hydroxylapatite. Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 1995, Volume: 25, Issue:1-3 Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Bentonite; Binding Sites; Durapatite; Evolution, Chemical; Evolution, Molecular; Hydrogen-Ion Concentration; Hypoxanthine; Nucleosides; Nucleotides; Origin of Life; Purines; Pyrimidines; RNA	1995
Adenylosuccinate lyase deficiency: from the clinics to molecular biology. Advances in experimental medicine and biology, 2000, Volume: 486 Topics: Adenosine; Adenosine Monophosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Enzyme Stability; Gene Expression; Heating; Humans; Recombinant Fusion Proteins; Ribonucleotides	2000
A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Developmental biology, 2002, May-01, Volume: 245, Issue:1 Topics: Adenosine; Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Enzyme Activation; Enzyme Inhibitors; Meiosis; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Oocytes; Pentostatin; Protein Serine-Threonine Kinases; Ribonucleotides	2002
Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. FEBS letters, 2002, Nov-06, Volume: 531, Issue:2 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Kinetics; Multienzyme Complexes; Muscle, Skeletal; Protein Kinases; Protein Serine-Threonine Kinases; Ribonucleosides; Ribonucleotides	2002
5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved. The Biochemical journal, 2003, Mar-15, Volume: 370, Issue:Pt 3 Topics: Adenosine; Affinity Labels; Amino Acid Chloromethyl Ketones; Aminoimidazole Carboxamide; Apoptosis; Caspases; Cyclic AMP-Dependent Protein Kinases; Cytochrome c Group; Enzyme Inhibitors; Humans; Jurkat Cells; Phosphorylation; Ribonucleosides; Thioinosine	2003
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. Blood, 2003, May-01, Volume: 101, Issue:9 Topics: Adenosine; Amino Acid Chloromethyl Ketones; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Apoptosis; B-Lymphocytes; Caspases; Cyclic AMP-Dependent Protein Kinases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Ribonucleosides; Ribonucleotides; T-Lymphocytes; Tubercidin; Tumor Cells, Cultured	2003
AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. Journal of neurochemistry, 2004, Volume: 88, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Male; Multienzyme Complexes; Nucleoside Transport Proteins; Nucleotides; Protein Serine-Threonine Kinases; Rats; Receptors, Purinergic P1; Ribonucleosides; Stress, Physiological; Synaptic Transmission	2004
5-Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochemical and biophysical research communications, 2004, May-28, Volume: 318, Issue:2 Topics: Adenosine; Adenosine Kinase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Enzyme Inhibitors; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Nucleoside Transport Proteins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Purinergic P1 Receptor Antagonists; Rats; Ribonucleotides; RNA, Messenger; Tumor Necrosis Factor-alpha	2004
Adenosine induces apoptosis in the human gastric cancer cells via an intrinsic pathway relevant to activation of AMP-activated protein kinase. Biochemical pharmacology, 2004, May-15, Volume: 67, Issue:10 Topics: Adenine; Adenosine; Adenylate Kinase; Aminoimidazole Carboxamide; Apoptosis; Caspase Inhibitors; Dipyridamole; Drug Interactions; Enzyme Activation; Humans; Membrane Potentials; Mitochondria; Receptors, Purinergic P1; Ribonucleotides; Signal Transduction; Stomach Neoplasms; Tumor Cells, Cultured	2004
Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation. Transplantation, 2004, Sep-15, Volume: 78, Issue:5 Topics: Acetylcysteine; Adenosine; Allopurinol; Aminoimidazole Carboxamide; Animals; Apoptosis; Creatinine; Disease Models, Animal; Dogs; Glutathione; Graft Survival; Immunohistochemistry; Insulin; Kidney; Kidney Transplantation; Male; Nephrectomy; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Preservation; Organ Preservation Solutions; Raffinose; Reperfusion Injury; Ribonucleotides; Transplantation, Autologous; Tumor Necrosis Factor-alpha	2004
Adenylosuccinate lyase deficiency--first British case. Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Catalysis; Exons; Fatal Outcome; Female; Heterozygote; Humans; Infant, Newborn; Mutation; Phenotype; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Ribonucleotides	2004
Demonstration of an alternative mechanism for G-to-G cross-link formation. Journal of the American Chemical Society, 2005, Jan-26, Volume: 127, Issue:3 Topics: Adenosine; Amines; Aminoimidazole Carboxamide; DNA; Guanosine; Mass Spectrometry; Models, Molecular; Nitrosation; Oligonucleotides; Ribonucleosides; Xanthines	2005
Preparation of 5-amino-4-imidazole-N-succinocarboxamide ribotide, 5-amino-4-imidazole-N-succinocarboxamide riboside and succinyladenosine, compounds usable in diagnosis and research of adenylosuccinate lyase deficiency. Journal of inherited metabolic disease, 2005, Volume: 28, Issue:4 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Biochemistry; Cations; Chemistry, Clinical; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cloning, Molecular; DNA, Complementary; Humans; Mutation; Phosphorylation; Purine-Pyrimidine Metabolism, Inborn Errors; Recombinant Proteins; Ribonucleotides; Substrate Specificity; Time Factors	2005
AMPK regulation of mouse oocyte meiotic resumption in vitro. Developmental biology, 2006, Mar-15, Volume: 291, Issue:2 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Female; Meiosis; Mice; Mice, Inbred C57BL; Microinjections; Multienzyme Complexes; Oocytes; Pentostatin; Protein Serine-Threonine Kinases; Ribonucleotides; Rosiglitazone; Thiazolidinediones; Vidarabine	2006
Moving preconditioning from bench to bedside. Journal of the American College of Cardiology, 2006, Jul-04, Volume: 48, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Artery Bypass; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion Injury; Ribonucleosides; Survival Rate	2006
Addition of adenosine monophosphate-activated protein kinase activators to University of Wisconsin solution: a way of protecting rat steatotic livers. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2007, Volume: 13, Issue:3 Topics: Adenine Nucleotides; Adenosine; Allopurinol; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activators; Fatty Liver; Glutathione; Insulin; Liver; Mitochondria, Liver; Multienzyme Complexes; Nitric Oxide; Nitric Oxide Synthase; Organ Preservation Solutions; Oxidative Stress; Protein Serine-Threonine Kinases; Raffinose; Rats; Rats, Zucker; Reperfusion Injury; Ribonucleotides; Trimetazidine; Vascular Resistance	2007
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2007, Volume: 31, Issue:2 Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Rats; Ribonucleosides	2007
Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. BMC biochemistry, 2007, Nov-29, Volume: 8 Topics: Adenosine; Aminoimidazole Carboxamide; Biomarkers, Tumor; Breast Neoplasms; Cell Line; Cell Line, Tumor; Epithelial Cells; Female; Guanosine; Humans; Imidazoles; Ions; Mammary Glands, Human; Metabolic Networks and Pathways; Ribonucleosides; Ribose; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uridine	2007
Implication of S-adenosylhomocysteine hydrolase in inhibition of TNF-alpha- and IL-1beta-induced expression of inflammatory mediators by AICAR in RPE cells. Investigative ophthalmology & visual science, 2008, Volume: 49, Issue:3 Topics: Adenosine; Adenosylhomocysteinase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cells, Cultured; Chemokine CCL2; Chemokines; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Interleukin-8; Multienzyme Complexes; Pigment Epithelium of Eye; Protein Serine-Threonine Kinases; Ribonucleotides; RNA, Small Interfering; Transfection; Tumor Necrosis Factor-alpha	2008
Clinical, biochemical, neuropathological and molecular findings of the first Polish case of adenylosuccinase deficiency. Folia neuropathologica, 2008, Volume: 46, Issue:1 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Brain; Brain Diseases, Metabolic, Inborn; Female; Humans; Infant; Infant, Newborn; Poland; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleosides	2008
D-ribose therapy in four Polish patients with adenylosuccinate lyase deficiency: absence of positive effect. Journal of inherited metabolic disease, 2008, Volume: 31 Suppl 2 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Blood Glucose; Child; Child, Preschool; Creatinine; Female; Growth Disorders; Humans; Poland; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleosides; Ribose; Seizures; Severity of Illness Index; Treatment Failure; Uric Acid	2008
Misleading behavioural phenotype with adenylosuccinate lyase deficiency. European journal of human genetics : EJHG, 2009, Volume: 17, Issue:1 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Angelman Syndrome; Behavior; Child; Chromatography, High Pressure Liquid; Consanguinity; Female; Humans; Intellectual Disability; Mutation, Missense; Pedigree; Phenotype; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; Sequence Analysis, DNA; Stereotyped Behavior	2009
Cardioprotection with adenosine-regulating agent, GP531: effects on no-reflow, infarct size, and blood flow following ischemia/ reperfusion in the rabbit. Journal of cardiovascular pharmacology and therapeutics, 2010, Volume: 15, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; Analysis of Variance; Animals; Deoxyribonucleosides; Disease Models, Animal; Hemodynamics; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Rabbits; Random Allocation	2010
Adenylosuccinate lyase deficiency in a Malaysian patient, with novel adenylosuccinate lyase gene mutations. Journal of inherited metabolic disease, 2010, Volume: 33 Suppl 3 Topics: Adenosine; Adenosine Monophosphate; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Biomarkers; Child Development; Chromatography, High Pressure Liquid; DNA Mutational Analysis; Genetic Predisposition to Disease; Genetic Testing; Heterozygote; Humans; Infant; Infant, Newborn; Malaysia; Male; Mutation; Myoclonus; Phenotype; Predictive Value of Tests; Psychomotor Disorders; Psychomotor Performance; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleosides; Seizures; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry	2010
Differential AMPK phosphorylation sites associated with phenylephrine vs. antihypertrophic effects of adenosine agonists in neonatal rat ventricular myocytes. American journal of physiology. Heart and circulatory physiology, 2010, Volume: 298, Issue:5 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cardiotonic Agents; Cardiovascular Agents; Cell Size; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Heart Ventricles; Leucine; Myocytes, Cardiac; Phenylephrine; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribonucleotides	2010
Adenosine regulates Sertoli cell function by activating AMPK. Molecular and cellular endocrinology, 2010, Dec-15, Volume: 330, Issue:1-2 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Animals; Egtazic Acid; Enzyme Activation; Gene Expression Regulation; Glucose; Glucose Transport Proteins, Facilitative; Intercellular Junctions; Isoenzymes; L-Lactate Dehydrogenase; Lactate Dehydrogenase 5; Lactates; Male; Monocarboxylic Acid Transporters; Protein Kinases; Rats; Rats, Sprague-Dawley; Ribonucleotides; RNA, Messenger; Sertoli Cells	2010
Adenosine activates AMPK to phosphorylate Bcl-XL responsible for mitochondrial damage and DIABLO release in HuH-7 cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011, Volume: 27, Issue:1 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Apoptosis; Apoptosis Regulatory Proteins; bcl-X Protein; Cell Line, Tumor; Humans; Intracellular Signaling Peptides and Proteins; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Proteins; Phosphorylation; Ribonucleotides; RNA Interference; RNA, Small Interfering	2011
5-Aminoimidazole-4-carboxyamide-ribonucleoside (AICAR)-stimulated hepatic expression of Cyp4a10, Cyp4a14, Cyp4a31, and other peroxisome proliferator-activated receptor α-responsive mouse genes is AICAR 5'-monophosphate-dependent and AMP-activated protein The Journal of pharmacology and experimental therapeutics, 2011, Volume: 339, Issue:3 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Coenzyme A Ligases; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Activation; Fatty Acids, Nonesterified; Genetic Vectors; Hepatocytes; Hydroxylation; Lauric Acids; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; PPAR alpha; Ribonucleotides	2011
Novel proton MR spectroscopy findings in adenylosuccinate lyase deficiency. Journal of magnetic resonance imaging : JMRI, 2013, Volume: 37, Issue:4 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Brain; Developmental Disabilities; DNA Mutational Analysis; Female; Humans; Image Enhancement; Image Interpretation, Computer-Assisted; Infant; Magnetic Resonance Spectroscopy; Male; Psychomotor Disorders; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleosides	2013
Inherent properties of adenylosuccinate lyase could explain S-Ado/SAICAr ratio due to homozygous R426H and R303C mutations. Biochimica et biophysica acta, 2013, Volume: 1834, Issue:8 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Chromatography, High Pressure Liquid; Electrochemistry; Homozygote; Humans; Kinetics; Mutagenesis, Site-Directed; Mutation, Missense; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleotides; Substrate Specificity	2013
Acute intravenous infusion of an adenosine regulating agent improves left ventricular function in dogs with advanced heart failure. Cardiovascular drugs and therapy, 2013, Volume: 27, Issue:6 Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Deoxyribonucleosides; Dogs; Heart Failure; Hemodynamics; Infusions, Intravenous; Purinergic P1 Receptor Antagonists; Theophylline; Ventricular Function, Left	2013
The need for vigilance: false-negative screening for adenylosuccinate lyase deficiency caused by deribosylation of urinary biomarkers. Clinical biochemistry, 2013, Volume: 46, Issue:18 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Bacterial Proteins; Child, Preschool; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Enterococcus faecalis; Enzymes; False Negative Reactions; Humans; Klebsiella pneumoniae; Purine-Pyrimidine Metabolism, Inborn Errors; Ribonucleosides; Tandem Mass Spectrometry; Urine	2013
Screening for adenylosuccinate lyase deficiency using tandem mass spectrometry analysis of succinylpurines in neonatal dried blood spots. Clinical biochemistry, 2015, Volume: 48, Issue:1-2 Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Carbon Isotopes; Chromatography, Liquid; Dried Blood Spot Testing; Humans; Infant, Newborn; Limit of Detection; Purine-Pyrimidine Metabolism, Inborn Errors; Reference Standards; Ribonucleosides; Tandem Mass Spectrometry	2015
AMP-activated protein kinase attenuates oxLDL uptake in macrophages through PP2A/NF-κB/LOX-1 pathway. Vascular pharmacology, 2016, Volume: 85 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aorta; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Foam Cells; Lipoproteins, LDL; Macrophages; Mice; Mice, Knockout; NF-kappa B; Okadaic Acid; Protein Phosphatase 2; Ribonucleotides; Scavenger Receptors, Class E	2016
AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias). American journal of physiology. Cell physiology, 2018, 04-01, Volume: 314, Issue:4 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Hypoxia; Chlorides; Cystic Fibrosis Transmembrane Conductance Regulator; Energy Metabolism; Enzyme Activation; Enzyme Activators; Fish Proteins; Perfusion; Phosphorylation; Protein Subunits; Ribonucleotides; Salt Gland; Secretory Pathway; Squalus acanthias; Tissue Culture Techniques	2018
Nucleosides block AICAR-stimulated activation of AMPK in skeletal muscle and cancer cells. American journal of physiology. Cell physiology, 2018, 12-01, Volume: 315, Issue:6 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Ascorbic Acid; Cell Line, Tumor; Culture Media; Diabetes Mellitus, Type 2; Energy Metabolism; Glucose; Humans; Muscle, Skeletal; Neoplasms; Nucleosides; Protein Kinases; Ribonucleotides; Thioctic Acid; Vitamin B 12	2018
Adult stem cell deficits drive Slc29a3 disorders in mice. Nature communications, 2019, 07-03, Volume: 10, Issue:1 Topics: Adenosine; Adenylate Kinase; Adult Stem Cells; Aminoimidazole Carboxamide; Animals; Autophagy; Biological Transport; Cell Differentiation; Cell Self Renewal; Energy Metabolism; Fatty Acids; HEK293 Cells; Humans; Lipid Metabolism; Lysosomes; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Nucleoside Transport Proteins; Phenotype; Ribonucleotides; Signal Transduction; Survival Analysis; TOR Serine-Threonine Kinases	2019
Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells. PloS one, 2020, Volume: 15, Issue:12 Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Cells, Cultured; Complement Activation; Complement C3; Humans; Macular Degeneration; Phosphorylation; Retinal Pigment Epithelium; Retinal Pigments; Ribonucleosides; Ribonucleotides; Tumor Necrosis Factor-alpha	2020