aminoimidazole carboxamide has been researched along with acadesine in 243 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (9.47) | 18.7374 |
| 1990's | 79 (32.51) | 18.2507 |
| 2000's | 73 (30.04) | 29.6817 |
| 2010's | 62 (25.51) | 24.3611 |
| 2020's | 6 (2.47) | 2.80 |
| Authors | Studies |
|---|---|
| Kaminski, PM; Proctor, KG | 1 |
| Bontemps, F; Van den Berghe, G; Vincent, MF | 2 |
| Bolling, SF; Gallagher, KP; Grinage, RA; Groh, MA; Mattson, AM | 1 |
| Bullough, D; Galiñanes, M; Hearse, DJ; Mullane, KM | 2 |
| Gruber, HE; Marangos, PJ; Van den Berghe, G; Vincent, MF | 1 |
| Gruber, HE; Marangos, P; Van den Berghe, G; Vincent, MF | 1 |
| Barankiewicz, J; Gruber, HE; Jimenez, R; Magill, M; Ronlov, G | 1 |
| Barankiewicz, J; Gruber, HE; Jimenez, R | 1 |
| Barankiewicz, J; Gruber, HE; Jimenez, R; Uyesaka, J | 1 |
| Bullough, DA; Fox, MH; Metzner, EK; Mullane, KM; Potter, S | 1 |
| Bullough, DA; Mullane, KM; Zhang, C | 1 |
| Burrier, AC; Jeng, AY; Oei, HH | 1 |
| Bleicher, JN; McBride, DM; Salerno, GM | 1 |
| Bergren, DR; Bergren, VA; Gruber, HE; Marquardt, DL; Townley, RG | 1 |
| Dewland, P; Dixon, R; Fujitaki, J; Gourzis, J; Gruber, H; McDermott, D | 1 |
| Clough-Helfman, C; Phillis, JW | 1 |
| Engler, RL; Gruber, HE; Hoffer, ME; Laikind, PK; Lane, TA; McAllister, DR; Schmid-Schoenbein, GW | 1 |
| Page, T | 1 |
| Adams, GR; Foley, JM; Meyer, RA | 1 |
| Chrastil, L; Dixon, R; Fujitaki, J; Lee, J | 1 |
| Nissim, I; Segal, S; Yudkoff, M | 1 |
| Nissim, I; States, B; Yudkoff, M | 1 |
| Gruber, HE; Marquardt, DL | 1 |
| Divald, A; Jeney, A; Lapis, K; Schaff, Z; Vajta, G; Zalatnai, A | 1 |
| Cornides, A; Deák, G; Fehér, J; Gergely, P; Láng, I; Nékám, K | 1 |
| Glower, DD; Newton, JR; Rankin, JS; Spratt, JA; Swain, JL; Wolfe, JA | 1 |
| Fukuda, T; Marumoto, R; Taniyama, Y | 1 |
| Gruber, HE; Laikind, PK; Seegmiller, JE | 1 |
| Flanagan, WF; Holmes, EW; Sabina, RL; Swain, JL | 1 |
| Hoffmeister, HM; Mauser, M; Nienaber, C; Schaper, W | 1 |
| Holmes, EW; Patterson, D; Sabina, RL | 1 |
| Shi, AY | 1 |
| Jolly, SR; Lucchesi, BR; Mitsos, SE | 1 |
| Holmes, EW; Meade, JC; Thomas, CB | 1 |
| Becker, MA; Holmes, EW; Sabina, RL | 1 |
| Pasque, MK; Wechsler, AS | 1 |
| Harbury, OL; Hines, JJ; Holmes, EW; Sabina, RL; Swain, JL | 1 |
| Kidder, GW; Nolan, LL | 1 |
| Hines, JJ; Holmes, EW; Sabina, RL; Swain, JL | 1 |
| Davies, MK; Flameng, W; Jamieson, WR; Menasché, P | 1 |
| Eglen, RM; Flippin, LA; Kim, EJ; Lazar, DA; Leung, E; Seran, CS; Walsh, LK; Wong, EH | 1 |
| Beger, HG; Gruber, H; Marzinzig, E; Marzinzig, M; Mattfeldt, T; Moch, D; Poch, B; Schoenberg, MH | 1 |
| Bullough, D; Mullane, K | 1 |
| Burckhartt, B; Cohen, MV; Downey, JM; Mullane, KM; Tsuchida, A; Yang, XM | 2 |
| Akkan, AG; Malaisse, WJ | 1 |
| Conget, I; Malaisse, WJ; Rorsman, P; Sener, A | 1 |
| Bullough, DA; Firestein, GS; Magill, MJ; Mullane, KM | 1 |
| Gruber, HE | 1 |
| Fabian, TC; Kudsk, KA; Proctor, KG; Spiers, JP | 1 |
| Gruber, HE; Henin, N; Van den Berghe, G; Vincent, MF | 1 |
| Alkhulaifi, AM; Pugsley, WB | 1 |
| Hudspeth, DA; McGee, DS; Sato, H; Van Wylen, DG; Vinten-Johansen, J; Williams, MW; Zhao, ZQ | 1 |
| Christopherson, RI; Szabados, E | 1 |
| Gruver, EJ; Marsh, JD; Smith, TW; Toupin, D | 1 |
| Barash, P; Curling, P; Hollenberg, M; Leung, JM; Mangano, DT; Mathew, J; Reves, JG; Salmenpera, M; Stanley, T | 1 |
| Dixon, R; Fujitaki, JM; Lembach, LA; Sandoval, TM | 1 |
| Alexis, N; Dewanjee, MK; Dewanjee, S; Dietrich, WD; Gruber, H; Miller, LP; Prado, R | 1 |
| Javaux, F; van den Berghe, G; Vincent, MF; Wagner, DR | 1 |
| Auszura, LA; Davis, E; Mathew, JP; O'Connor, T; Rinder, CS; Smith, BR; Tracey, JB | 1 |
| Fox, KM; Holdright, DR; Sparrow, JL; Steiner, J; Wright, CL | 1 |
| Bullough, DA; Montag, A; Mullane, KM; Young, MA; Zhang, C | 1 |
| Hori, M; Inoue, M; Kamada, T; Kitakaze, M; Komamura, K; Minamino, T; Morioka, T; Node, K; Sato, H; Takashima, S | 1 |
| Kingma, JG; Rouleau, JR; Simard, D | 1 |
| Aronson, S | 1 |
| Dai, HB; Friedman, M; Johnson, RG; Piana, RN; Sellke, FW; Wang, SY | 1 |
| Engler, RL | 1 |
| Demigne, C; Morand, C; Remesy, C | 1 |
| Diebold, RJ; Newman, JD; Noel, KD; Schultz, BW | 1 |
| McGee, DS; Nakanishi, K; Tan, P; Vinten-Johansen, J; Zhao, ZQ | 1 |
| Dixon, R; Fujitaki, J; Kisicki, J; Sandoval, T | 1 |
| Fridland, A; Gong, YF; Srinivas, RV | 1 |
| Bökkerink, JP; De Abreu, RA; Lambooy, LH; Stet, EH; Trijbels, FJ; Trueworthy, RC; Vogels-Mentink, TM | 1 |
| Bullough, DA; Fox, MH; Metzner, EK; Mullane, KM; Potter, S; Zhang, C | 1 |
| Downey, JM; Liu, GS; Mullane, K; Tsuchida, A | 1 |
| Mullane, K | 1 |
| Bullough, D; Henry, C; Mullane, K; Wong, S; Young, MA | 1 |
| Fabian, MJ; Fabian, TC; Proctor, KG; Yockey, JM | 1 |
| Ichihara, K; Kano, S; Kohri, H; Nakai, T | 1 |
| White, TD | 1 |
| Downs, SM | 1 |
| Aggarwal, A; Comunale, ME; Ghoshal, S; Hollenberg, M; Jain, U; Laflamme, CJ; Mangano, DT; Ngo, L; Ramsay, JG; Ziola, K | 1 |
| Cheng, TO | 1 |
| Bouma, MG; Buurman, WA; van den Wildenberg, FA | 1 |
| de Jong, JW; de Jonge, R; Friedman, J; Macleod, DC; Serruys, PW; Suryapranata, H; van Es, GA | 1 |
| Hardie, DG; Kurth, EJ; Merrill, GF; Winder, WW | 1 |
| Edelman, M; Moallem, TM; Sobolev, V; Vriend, G; Wade, RC | 1 |
| Kramer, B; Lengauer, T; Rarey, M | 1 |
| Carling, D; Hardie, DG; Lu, QL; Morgan, JE; Partridge, TA; Ponticos, M | 1 |
| Hill, GE | 1 |
| Carling, D; Ferré, P; Foretz, M; Foufelle, F; Guichard, C | 1 |
| Bache, RJ; Duncker, DJ; Ishibashi, Y; Klassen, C; Quebbeman, BB | 1 |
| Lee, HT | 1 |
| Richardt, G; Schreieck, J | 1 |
| Unkle, DW | 1 |
| Croce, MA; Fabian, TC; Melton, SM; Moomey, CB; Proctor, KG; Ragsdale, DN; Trenthem, LL | 1 |
| Goodyear, LJ; Hirshman, MF; Kurth-Kraczek, EJ; Winder, WW | 1 |
| Hori, M; Kitakaze, M; Kuzuya, T; Minamino, T; Mori, H; Node, K; Shinozaki, Y; Takashima, S | 1 |
| Hegge, JO; Lasley, RD; Mentzer , RM; Randhawa, MP | 1 |
| Hardie, DG; Lochhead, PA; Salt, IP; Sutherland, C; Walker, KS | 1 |
| Hayashi, Y; Honda, S; Itakura, M; Katashima, R; Kondo, M; Miwa, Y; Moritani, M; Yamaoka, T; Yoshimoto, K | 1 |
| Allegrini, S; Camici, M; Garcia-Gil, M; Jacomelli, G; Micheli, V; Peruzzi, L; Pesi, R; Tozzi, MG | 1 |
| Davis, KA; Fabian, TC; Proctor, KG; Ragsdale, DN; Trenthem, LL | 1 |
| Proctor, KG; Ragsdale, DN | 1 |
| Jurim, O; Matot, I | 1 |
| Chen, HQ; Kowluru, A; Modrick, LM; Stefanelli, C | 1 |
| Hardie, DG; Jakobsen, SN; Morrice, N; Tornqvist, HE | 1 |
| Akkan, AG; Ince, E; Kaya, F; Ozturk, M; Ozyazgan, S; Senses, V; Sultuybek, G; Tuncdemir, M | 1 |
| Hardie, DG; Hellsten, Y; Jørgensen, SB; Richter, EA; Wojtaszewski, JF | 1 |
| Baldwin, SA; Barnes, K; Carling, D; Foufelle, F; Fryer, LG; Woods, A | 1 |
| Goto, M; Kato, M; Kawanaka, K; Shimokawa, T; Tabata, I; Terada, S | 1 |
| Bertrand, L; Browne, G; Horman, S; Hue, L; Krause, U; Lavoinne, A; Patel, J; Proud, C; Rider, M; Vertommen, D | 1 |
| Carling, D; Fryer, LG; Parbu-Patel, A | 1 |
| Campàs, C; Gil, J; López, JM; Santidrián, AF | 1 |
| Goodyear, LJ; Musi, N | 1 |
| Barragán, M; Bellosillo, B; Campàs, C; Colomer, D; Gil, J; Lopez, JM; Santidrián, AF | 1 |
| Heimberg, H; Hue, L; Kefas, BA; Meisse, D; Pipeleers, D; Van de Casteele, M; Vaulont, S | 1 |
| Allegrini, S; Camici, M; Garcia-Gil, M; Giannecchini, M; Perna, S; Pesi, R; Tozzi, MG | 1 |
| Cai, Y; Heimberg, H; Hue, L; Kefas, BA; Ling, Z; Pipeleers, D; Van de Casteele, M | 1 |
| Fengsrud, M; Møller, MT; Samari, HR; Seglen, PO; Strømhaug, PE; øStvold, AC | 1 |
| Abbott, CR; Andersson, U; Bloom, SR; Carling, D; Filipsson, K; Small, CJ; Smith, K; Woods, A | 1 |
| Currie, AJ; Dale, N; Frenguelli, BG; Gadalla, AE; Hardie, DG; Hawley, SA; Hirst, W; Michel, AD; Pearson, T; Randall, A; Sheehan, M | 1 |
| Burcelin, R; Knauf, C; Perrin, C | 1 |
| Hardie, DG | 1 |
| Churchill, T; Diaz, H; Jijon, HB; Madsen, KL; Salehi, P; Walker, J | 1 |
| Campàs, C; Domingo, A; Gil, J; Santidrián, AF | 1 |
| Friedberg, T; Hardie, DG; Hawley, SA; Rencurel, F; Stenhouse, A; Sutherland, C; Wolf, CR | 1 |
| Binkowski, DJ; Fromm, HJ; Honzatko, RB; Nelson, SW | 1 |
| Beckers, A; Brusselmans, K; De Schrijver, E; Deboel, L; Derua, R; Foufelle, F; Noël, A; Organe, S; Segers, J; Swinnen, JV; Timmermans, L; Van de Sande, T; Vanderhoydonc, F; Verhoeven, G; Waelkens, E | 1 |
| Bell, GI; Di, A; Magnuson, MA; Nelson, DJ; Philipson, LH; Roe, MW; Wang, CZ; Wang, Y; Ye, H | 1 |
| Bazin, R; Daval, M; Diot-Dupuy, F; Ferré, P; Foufelle, F; Hainault, I; Hajduch, E; Vaulont, S; Viollet, B | 1 |
| Baik, HH; Ha, J; Jhun, BS; Kang, I; Kim, SS; Kong, Y; Lee, JY; Oh, YT; Yoon, KS | 1 |
| Balschi, JA; Frederich, M; He, H; Zhang, L | 1 |
| Ebihara, K; Fushiki, T; Hamada, T; Hayashi, T; Hosoda, K; Inoue, G; Masuzaki, H; Miyamoto, L; Nakano, M; Nakao, K; Ogawa, Y; Otaka, A; Tanaka, S; Toyoda, T; Yonemitsu, S; Yoshimasa, Y | 1 |
| Chan, O; Cheng, H; Ding, Y; Fan, X; McCrimmon, RJ; McNay, E; Shaw, M; Sherwin, RS; Zhu, W | 1 |
| Fuchsel, L; Goldstein, BJ; Hough, K; Mahadev, K; Motoshima, H; Ouedraogo, R; Scalia, R; Wu, X; Xu, SQ | 1 |
| Shakulov, RS | 1 |
| Adam, T; Friedecký, D; Hornik, P; Vyskocilová, P | 1 |
| Dietzel, C; Mangano, DT; Miao, Y; Tudor, IC | 1 |
| Kloner, RA | 1 |
| Beckers, A; Brusselmans, K; Deboel, L; Derua, R; Organe, S; Swinnen, JV; Timmermans, L; Vanderhoydonc, F; Verhoeven, G; Waelkens, E | 1 |
| Choudhury, GG; Feliers, D; Foretz, M; Kasinath, BS; Lee, MJ; Mahimainathan, L; Mariappan, MM; Musi, N; Sataranatarajan, K; Viollet, B; Weinberg, JM | 1 |
| Adam, T; Bednár, P; Friedecký, D; Procházka, M | 1 |
| Adam, T; Friedecký, D; Frycák, P; Hornik, P; Lemr, K; Vyskocilová, P | 1 |
| Bertini, F; Camici, M; Garcia-Gil, M; Pesi, R; Tozzi, MG; Voccoli, V | 1 |
| Ebihara, K; Fushiki, T; Hayashi, T; Hosoda, K; Inoue, G; Masuzaki, H; Miyamoto, L; Nakano, M; Nakao, K; Ogawa, Y; Tanaka, S; Toyoda, T; Yonemitsu, S | 1 |
| Higgins, JP; Simmonds, MC | 1 |
| De-Castro Arce, J; Fleig, V; Mazurek, S; Nafz, J; Patzelt, A; Rösl, F | 1 |
| Andreelli, F; Detaille, D; Foretz, M; Guigas, B; Hue, L; Taleux, N; Viollet, B | 1 |
| Baggott, JE; Morgan, SL | 1 |
| Chao, Y; Chen, TY; Huang, DY; Lin, WW; Su, RY | 1 |
| Baar, K; Babraj, JA; Cuthbertson, DJ; Green, KA; Hardie, DG; Leese, GP; Mustard, KJ; Rennie, MJ; Sutherland, C; Thomason-Hughes, M; Towler, MC; Wackerhage, H | 1 |
| Chang, MY; Ho, FM; Kuo, CL; Lin, WW; Prakash, E | 1 |
| Fukuda, T; Ishii, K; Isobe, K; Kawakami, Y; Nanmoku, T; Takekoshi, K | 1 |
| Favero, CB; Mandell, JW | 1 |
| Cigorraga, SB; Galardo, MN; Meroni, SB; Pellizzari, EH; Riera, MF | 1 |
| Bullinger, D; Fehm, T; Gleiter, CH; Kammerer, B; Laufer, S; Neubauer, H | 1 |
| Cronstein, BN; Kamen, BA | 1 |
| Aguado, C; Esteban, I; Knecht, E; Moreno, D; Sanz, P; Viana, R; Viollet, B | 1 |
| Chi, MM; Louden, E; Moley, KH | 1 |
| Chakour, KS; Freund, GG; Guest, CB | 1 |
| Drew, BG; Kingwell, BA | 1 |
| López, JM | 1 |
| Jellinek, M | 1 |
| Guigas, B; Hue, L; Musi, N; Reyna, SM; Sakamoto, K; Taleux, N; Viollet, B | 1 |
| Frost, RA; Kazi, AA; Lang, CH; Pruznak, AM; Vary, TC | 1 |
| Kim, EJ; Lee, SW; Lee, YG; Sin, HS; Um, SJ | 1 |
| Adamo, L; García-Cardeña, G; Zhang, Y | 1 |
| Boon, H; Bosselaar, M; Smits, P; Tack, CJ; van den Broek, PH; van Loon, LJ | 1 |
| Du, M; Tong, JF; Yan, X; Zhu, MJ | 1 |
| Gillespie, MT; Kemp, BE; McGregor, NE; Poulton, IJ; Quinn, JM; Saleh, H; Scott, JW; Sims, NA; Tam, S; van Denderen, BJ | 1 |
| Bandyopadhyay, G; Braun, U; Farese, RV; Foufelle, F; Hainault, I; Kahn, R; Leitges, M; Longnus, SL; Miura, A; Nimal, S; Sajan, MP; Standaert, ML; Van Obberghen, E | 1 |
| Auberger, P; Belhacene, N; Ben Sahra, I; Bost, F; Cassuto, JP; Colosetti, P; Gounon, P; Hofman, P; Puissant, A; Robert, G | 1 |
| Belcher, JD; Geng, JG; Huo, Y; Slungaard, A; Tang, R; Viollet, B; Wang, H; Wang, J; Wu, C; Zhang, C; Zhang, W; Zhu, C | 1 |
| Bontemps, F; Van den Berghe, G; Van Den Neste, E | 1 |
| Brault, JJ; Goldberg, AL; Jespersen, JG | 1 |
| Bilodeau-Goeseels, S; Kastelic, JP; Panich, PL | 1 |
| Alonso, E; Benito, A; Campàs, C; Coll-Mulet, L; Cosialls, AM; de Frias, M; Gil, J; González-Barca, E; González-Gironès, DM; Iglesias-Serret, D; Labi, V; Pons, G; Santidrián, AF; Villunger, A; Viollet, B | 1 |
| Bai, G; Feng, B; Pozharski, E; Shapiro, M; Wang, JB | 1 |
| Ge, W; Li, Q; Ren, J; Turdi, S; Wang, XM | 1 |
| Akhmadyshin, RA; Gronskiy, SV; Livshits, VA; Novikova, AE; Shakulov, RS; Sheremet, AS; Zakataeva, NP | 1 |
| Gao, XJ; Li, QZ; Yan, HB; Zhang, N | 1 |
| Hsu, MH; Johnson, EF; Lasker, JM; Savas, U | 1 |
| Albers, PH; Birk, JB; Dzamko, N; Jeppesen, J; Kiens, B; Rose, AJ; Schjerling, P; Steinberg, GR | 1 |
| Crabb, DW; Liangpunsakul, S; Lu, C; Sozio, MS; Zeng, Y | 1 |
| Rutten, M; Smith Sonneborn, J | 1 |
| Coppa, GF; Idrovo, JP; Matsuda, A; Nicastro, J; Wang, P; Yang, WL | 1 |
| Begg, AC; Haustermans, KM; Isebaert, SF; McBride, WH; Swinnen, JV | 1 |
| Apostolova, N; Blas-García, A; Marti-Cabrera, M; Martínez-Martín, N; Monleón, D; Morales, JM | 1 |
| Broxmeyer, HE; Chae, HD; Lee, MR | 1 |
| Song, P; Wang, S; Zou, MH | 1 |
| Azazmeh, N; Azulay, N; Bar-Tana, J; Kalderon, B; Valitsky, M; Vissler, N | 1 |
| Chen, X; Hermansen, K; Jeppesen, PB | 1 |
| Ambrosio, G; Ferguson, TB; Harrington, RA; Koglin, J; Lira, A; Newman, MF; Nussmeier, NA; Pearl, RG; Pitt, B; Reece, TL; Wechsler, AS; Weisel, RD; White, JA | 1 |
| Inoue, J; Nanmoku, M; Sato, R; Shimizu, M; Yashiro, T | 1 |
| Campàs, C; Cazin, B; de Frias, M; González-Barca, E; Janssens, A; Levy, V; Pérez de Oteyza, J; Saunders, A; Terol, MJ; Van Den Neste, E; Zachee, P | 1 |
| Chang, JW; Kim, JH; Kim, JS; Kim, SB; Lee, JH; Lee, SK; Park, JS | 1 |
| Cheng, X; Guo, L; Li, L; Li, Z; Lu, W; Zhou, T | 1 |
| Bornfeldt, KE; Chait, A; Cheng, AM; Clowes, AW; Daum, G; Handa, P; Kanter, JE; Kim, F; Morgan-Stevenson, V; Ogimoto, K; Rizzo-De Leon, N; Tateya, S | 1 |
| Briski, KP; Cherian, AK; Gujar, AD; Ibrahim, BA; Tamrakar, P | 1 |
| Amato, J; Borbone, N; D'Errico, S; Mayol, L; Oliviero, G; Piccialli, G; Piccialli, V; Varra, M | 1 |
| Beauloye, C; Bertrand, L; Bouleti, C; Castanares-Zapatero, D; Communi, D; Foretz, M; Gerber, B; Germain, S; Horckmans, M; Horman, S; Laterre, PF; Lecut, C; Mathivet, T; Oury, C; Sommereyns, C; Vanoverschelde, JL; Viollet, B | 1 |
| Bikopoulos, G; Ceddia, RB; Curi, R; Hung, S; Vitzel, KF | 1 |
| Becker, KG; Collica, SC; Guerrieri, D; Kobilo, T; van Praag, H; Zhang, Y | 1 |
| Beà, S; Campàs, C; Colomer, D; de Frias, M; Kalko, SG; López-Guerra, M; Montraveta, A; Pérez-Galán, P; Rosich, L; Roué, G; Salaverria, I; Xargay-Torrent, S | 1 |
| García Martínez, J; García-Inclán, C; Hermsen, MA; Llorente, JL; Suárez, C | 1 |
| Chang, HW; Cho, YS; Hwang, SL; Jahng, Y; Kang, W; Kim, YD; Lee, YJ; Li, X; Lu, Y; Moon, TC; Murakami, M; Son, JK; Taketomi, Y | 1 |
| Calderon, PB; Dejeans, N; Glorieux, C; Najimi, M; Renard, P; Rommelaere, G; Sid, B; Valenzuela, M; Verrax, J | 1 |
| Ambrosio, G; Clare, RM; Ferguson, TB; Fremes, S; Harrington, RA; Lira, A; Menasché, P; Mongero, L; Newman, MF; Nussmeier, N; Pearl, RG; Pieper, KS; Pitt, B; Reece, TL; Wechsler, AS; Weisel, RD; Yau, TM | 1 |
| Jiang, H; Li, G; Yao, W | 1 |
| Al-Rewashdy, H; Jasmin, BJ; Lin, W; Ljubicic, V; Renaud, JM | 1 |
| Alenazi, FS; Briski, KP; Ibrahim, BA | 1 |
| Ai, Q; Ge, P; Gong, X; Lin, L; Yang, C; Zhang, L | 1 |
| Deura, C; Goto, T; Hirabayashi, M; Ikegami, K; Inoue, N; Maeda, K; Minabe, S; Sanbo, M; Tsukamura, H; Uenoyama, Y | 1 |
| Abboud, HE; Barnes, JL; Block, K; Gorin, Y; Kopp, JB; Shi, Q; Thakur, S; Viswanadhapalli, S | 1 |
| Campàs, C; Campo, E; Colomer, D; de Frías, M; Lee-Vergés, E; López-Guerra, M; Montraveta, A; Rodríguez, V; Roldán, J; Rosich, L; Roué, G; Xargay-Torrent, S | 1 |
| Aoyagi, M; Asano, K; Haneishi, A; Kanai, Y; Komatsu, Y; Moriizumi, M; Ono, M; Otsuka, H; Takagi, K; Tanaka, T; Tomita, K; Tsuchiya, Y; Tsukada, A; Yamada, K; Yanagisawa, Y; Yokouchi, H | 1 |
| Cambon, K; Déglon, N; Dolores Sequedo, M; Farina, F; Millán, JM; Neri, C; Parker, AJ; Vázquez-Manrique, RP; Weiss, A | 1 |
| Deng, ZK; Ding, YH; Li, YF; Shi, YY; Wei, B; Wu, JJ | 1 |
| Egilmez, NK; Hao, J; Li, B; Li, Q; Rao, E; Suttles, J; Zhang, Y | 1 |
| Berggren, PO; Zaitsev, SV; Zaitseva, II | 1 |
| Fujinami, K; Kamoshita, M; Ozawa, Y; Toda, E; Tsubota, K | 1 |
| Bailly-Chouriberry, L; Bonnaire, Y; Brooks, L; Cawley, A; Chambers, A; Chan, GHM; Choi, TLS; Ho, ENM; Jaubert, M; Keledjian, J; Kwok, WH; Lin, Y; Ming Williams, H; Wan, TSM; Wong, JKY | 1 |
| Hayashi, T; Ikejima, T; Peng, SQ; Wang, YM; Zhang, TG; Zhao, J | 1 |
| Albericio, F; Cosialls, AM; de la Banda, E; Gil, J; González-Barca, EM; González-Gironès, DM; Iglesias-Serret, D; Lavilla, R; Núñez-Vázquez, S; Pomares, H; Pons, G; Preciado, S; Saura-Esteller, J | 1 |
| Chung, EJ; Efstathiou, NE; Konstantinou, EK; Maidana, DE; Miller, JW; Vavvas, DG; Young, LH | 1 |
| Dembitz, V; Lalic, H; Visnjic, D | 1 |
| Bush, ND; Townsend, LK; Wright, DC | 1 |
| Daignan-Fornier, B; Dompierre, J; Moenner, M; Pantesco, V; Philippe, C; Pinson, B; Viollet, B | 1 |
| Miyamoto, L | 1 |
| Li, X; Lin, M; Men, J; Wang, Q; Yuan, Y; Zhang, M | 1 |
| Bedalov, A; Dembitz, V; Kodvanj, I; Simon, JA; Tomic, B; Visnjic, D | 1 |
| Abdullahi, A; Auger, C; Jeschke, MG; Knuth, CM; Parousis, A; Samadi, O | 1 |
| Kivero, AD; Skripnikova, VS; Yusupova, YR; Zakataeva, NP | 1 |
| Batinic, D; Batinic, J; Bedalov, A; Dembitz, V; Dubravcic, K; Kodvanj, I; Lalic, H; Tomic, B; Visnjic, D | 1 |
| Fukushima, A; Furihata, T; Handa, H; Kakutani, N; Kinugawa, S; Maekawa, S; Matsumoto, J; Mizushima, W; Nakano, I; Nambu, H; Sabe, H; Takada, S; Tanaka, S; Yokota, T | 1 |
| Barbisan, PRT; Efstathiou, NE; Georgakopoulos, CD; Konstantinou, EK; Maidana, DE; Miller, JW; Moustafa, GA; Notomi, S; Vavvas, DG | 1 |
| An, ZN; Ge, MH; Jiang, DW; Liu, C; Shen, XL; Wei, DZ; Xing, XJ; Zheng, DM | 1 |
| Chen, B; Chen, J; Duan, F; Pan, Z; Wang, X; Wang, Y; Wu, M; Zhang, L; Zhang, Y; Zhu, X | 1 |
16 review(s) available for aminoimidazole carboxamide and acadesine
| Article | Year |
|---|---|
Metabolic intervention to affect myocardial recovery following ischemia.
Topics: Adenine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Citric Acid Cycle; Coronary Circulation; Coronary Disease; Fructosediphosphates; Glucose; Glycogen; Heart; Humans; Inosine; Myocardium; Oxidative Phosphorylation; Ribonucleosides; Ribose | 1984 |
Harnessing an endogenous cardioprotective mechanism: cellular sources and sites of action of adenosine.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Carrier Proteins; Dogs; Endothelium, Vascular; Energy Metabolism; Guinea Pigs; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Rabbits; Rats; Receptors, Purinergic P1; Reperfusion Injury; Ribonucleosides; Signal Transduction | 1995 |
Acadesine: preclinical overview.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Vessels; Dogs; Heart; Heart Transplantation; Muscle, Smooth, Vascular; Myocardial Stunning; Rats; Ribonucleosides | 1994 |
Harnessing nature's own cardiac defense mechanism with acadesine, an adenosine regulating agent: importance of the endothelium.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Endothelium, Vascular; Heart; Humans; Myocardial Reperfusion Injury; Myocardial Stunning; Ribonucleosides | 1994 |
Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury.
Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Dogs; Guinea Pigs; Humans; Myocardial Reperfusion Injury; Myocardium; Rats; Ribonucleosides | 1993 |
The anti-inflammatory potential of adenosine in ischemia-reperfusion injury: established and putative beneficial actions of a retaliatory metabolite.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiovascular System; Enzyme Inhibitors; Humans; Ischemic Preconditioning; Nucleosides; Receptors, Purinergic P1; Reperfusion Injury; Ribonucleosides | 1997 |
Cardiopulmonary bypass-induced inflammation: is it important?
Topics: Aminoimidazole Carboxamide; Anti-Inflammatory Agents; Cardiopulmonary Bypass; Cell Adhesion; Child; Cytokines; Down-Regulation; Endothelium, Vascular; Endotoxins; Hemofiltration; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Interleukin-1; Interleukin-6; Macrophage-1 Antigen; Myocardial Ischemia; Myocardial Reperfusion Injury; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Platelet Activation; Ribonucleosides; Serine Proteinase Inhibitors; Systemic Inflammatory Response Syndrome; Tumor Necrosis Factor-alpha; Up-Regulation; Ventricular Dysfunction, Left | 1998 |
Mechanisms of ischemic preconditioning and clinical implications for multiorgan ischemic-reperfusion injury.
Topics: Adenosine; Aminoimidazole Carboxamide; Anesthesia; Animals; Humans; Ischemic Preconditioning; Liver; Reperfusion Injury; Ribonucleosides; Surgical Procedures, Operative; Thoracic Surgical Procedures | 1999 |
Acadesine during fluid resuscitation from shock and abdominal sepsis.
Topics: Aminoimidazole Carboxamide; Animals; Cecum; Female; Fluid Therapy; Hemodynamics; Intestinal Mucosa; Leukocyte Count; Ligation; Male; Oxygen Consumption; Random Allocation; Reperfusion Injury; Resuscitation; Ribonucleosides; Sepsis; Shock, Hemorrhagic; Swine; Tumor Necrosis Factor-alpha | 1999 |
Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.
Topics: Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Diabetes Mellitus, Type 2; Enzyme Activators; Exercise; Glucose; Humans; Hypoglycemic Agents; Insulin; Multienzyme Complexes; Muscle Contraction; Muscle, Skeletal; Protein Serine-Threonine Kinases; Ribonucleosides | 2002 |
AMP-activated protein kinase: the guardian of cardiac energy status.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Energy Metabolism; Enzyme Activation; Humans; Models, Biological; Multienzyme Complexes; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Necrosis; Protein Serine-Threonine Kinases; Ribonucleosides; Trans-Activators | 2004 |
Acadesine, an adenosine-regulating agent with the potential for widespread indications.
Topics: Adenosine; Aminoimidazole Carboxamide; Coronary Artery Bypass; Diabetes Mellitus; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Myocardial Reperfusion Injury; Ribonucleosides | 2008 |
Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Enzyme Activators; Glucose; Homeostasis; Humans; Molecular Structure; Phosphorylation; Pyrones; Ribonucleosides; Thiophenes | 2009 |
AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Clinical Trials as Topic; Enzyme Activation; Hematologic Neoplasms; Humans; Ribonucleosides | 2010 |
The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Clinical Trials as Topic; Humans; Leukemia, Myeloid, Acute; Metformin; Ribonucleosides; RNA, Small Interfering; Signal Transduction; Sirolimus; TOR Serine-Threonine Kinases | 2019 |
[AMPK as a Metabolic Intersection between Diet and Physical Exercise].
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Diet; Drug Discovery; Eating; Exercise; Exercise Therapy; Humans; Hypoglycemic Agents; Isoenzymes; Metabolic Diseases; Metformin; Molecular Targeted Therapy; Muscle Contraction; Pyrones; Ribonucleosides; Thiophenes | 2018 |
14 trial(s) available for aminoimidazole carboxamide and acadesine
| Article | Year |
|---|---|
AICA-riboside: safety, tolerance, and pharmacokinetics of a novel adenosine-regulating agent.
Topics: Administration, Oral; Adult; Aminoimidazole Carboxamide; Double-Blind Method; Erythrocytes; Humans; Infusions, Intravenous; Male; Protein Binding; Ribonucleosides | 1991 |
Acadesine: a new drug that may improve myocardial protection in coronary artery bypass grafting. Results of the first international multicenter study. Multinational Acadesine Study Group.
Topics: Aminoimidazole Carboxamide; Cause of Death; Coronary Artery Bypass; Coronary Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Prospective Studies; Regression Analysis; Ribonucleosides; Risk Factors; Treatment Outcome | 1995 |
Effects of acadesine on the incidence of myocardial infarction and adverse cardiac outcomes after coronary artery bypass graft surgery. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.
Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Female; Hemodynamics; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Ribonucleosides; Ventricular Function, Left | 1995 |
An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery. SPI Research Group.
Topics: Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Elective Surgical Procedures; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Ischemia; Ribonucleosides; Safety | 1994 |
Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass.
Topics: Adenosine; Aminoimidazole Carboxamide; Cardiopulmonary Bypass; CD18 Antigens; Female; Humans; Macrophage-1 Antigen; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Receptors, Cytoadhesin; Ribonucleosides; Up-Regulation | 1995 |
Effect of acadesine, a new metabolic agent, on exercise-induced myocardial ischemia in chronic stable angina.
Topics: Aged; Aminoimidazole Carboxamide; Angina Pectoris; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Exercise Test; Female; Humans; Infusions, Intravenous; Male; Middle Aged; Myocardial Ischemia; Placebos; Ribonucleosides; Time Factors | 1994 |
Electrocardiographic and hemodynamic changes and their association with myocardial infarction during coronary artery bypass surgery. A multicenter study. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.
Topics: Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Creatine Kinase; Electrocardiography; Female; Hemodynamics; Humans; Male; Middle Aged; Myocardial Infarction; Myocardium; Predictive Value of Tests; Ribonucleosides; Stroke Volume; Ventricular Function, Left | 1997 |
Effect of acadesine on myocardial ischaemia in patients with coronary artery disease.
Topics: Adult; Aged; Aminoimidazole Carboxamide; Cardiac Catheterization; Coronary Disease; Female; Hemodynamics; Humans; Lactic Acid; Male; Middle Aged; Myocardial Ischemia; Ribonucleosides; Ventricular Function, Left | 1997 |
Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine.
Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Double-Blind Method; Female; Humans; Male; Middle Aged; Myocardial Infarction; Myocardial Reperfusion Injury; Preoperative Care; Ribonucleosides; Risk Factors; Survival Rate | 2006 |
5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.
Topics: Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biopsy; Blood Glucose; Deoxyglucose; Glycogen; Health; Hormones; Humans; Insulin; Isoenzymes; Lactic Acid; Male; Multienzyme Complexes; Muscle, Skeletal; Protein Serine-Threonine Kinases; Ribonucleosides; Time Factors | 2007 |
Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle.
Topics: Adult; Aminoimidazole Carboxamide; Brachial Artery; Caffeine; Cells, Cultured; Enzyme Inhibitors; Female; Forearm; Hemodynamics; Humans; Injections, Intra-Arterial; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Regional Blood Flow; Ribonucleosides; Vasodilation; Young Adult | 2009 |
Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial.
Topics: Adenosine; Aged; Aminoimidazole Carboxamide; Coronary Artery Bypass; Coronary Artery Disease; Double-Blind Method; Female; Humans; Male; Middle Aged; Perioperative Period; Reperfusion Injury; Ribonucleosides; Stroke; Ventricular Dysfunction, Left | 2012 |
Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II study.
Topics: Aged; Aminoimidazole Carboxamide; B-Lymphocytes; Cohort Studies; Drug Resistance, Neoplasm; Female; Humans; Karnofsky Performance Status; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph; Lymphocyte Count; Male; Maximum Tolerated Dose; Middle Aged; Recurrence; Ribonucleosides; T-Lymphocytes | 2013 |
Predictors of contemporary coronary artery bypass grafting outcomes.
Topics: Age Factors; Aminoimidazole Carboxamide; Aspirin; Cardiopulmonary Bypass; Cardiovascular Agents; Chi-Square Distribution; Coronary Artery Bypass; Double-Blind Method; Heart Failure; Humans; Logistic Models; Multivariate Analysis; Odds Ratio; Patient Selection; Peripheral Arterial Disease; Protective Factors; Ribonucleosides; Risk Assessment; Risk Factors; Stroke; Stroke Volume; Time Factors; Treatment Outcome; Ventricular Dysfunction, Left; Ventricular Function, Left | 2014 |
213 other study(ies) available for aminoimidazole carboxamide and acadesine
| Article | Year |
|---|---|
Extracellular and intracellular actions of adenosine and related compounds in the reperfused rat intestine.
Topics: 2-Chloroadenosine; Adenosine; Aminoimidazole Carboxamide; Animals; Dipyridamole; Intestines; Male; Purinergic Antagonists; Rats; Rats, Inbred Strains; Receptors, Purinergic; Reperfusion Injury; Ribonucleosides; Theophylline | 1992 |
Inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside in isolated rat hepatocytes.
Topics: Aminoimidazole Carboxamide; Animals; Biotransformation; Cells, Cultured; Fructosediphosphates; Gluconeogenesis; Glucose; Glycolysis; Kinetics; Lactates; Liver; Male; Phosphofructokinase-1; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Ribonucleosides; Ribonucleotides; Tritium | 1992 |
Acadesine (AICA-riboside) improves postischemic cardiac recovery.
Topics: Aminoimidazole Carboxamide; Animals; Cardiac Output; Constriction; Coronary Artery Bypass; Dogs; Heart; Heart Arrest, Induced; Myocardial Contraction; Ribonucleosides; Vascular Resistance | 1992 |
Sustained protection by acadesine against ischemia- and reperfusion-induced injury. Studies in the transplanted rat heart.
Topics: Abdomen; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Heart Transplantation; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion; Myocardial Reperfusion Injury; Myocardium; Potassium Chloride; Rats; Rats, Inbred Lew; Ribonucleosides; Sodium Chloride; Time Factors; Transplantation, Heterotopic | 1992 |
Acadesine and myocardial protection. Studies of time of administration and dose-response relations in the rat.
Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Animals; Bicarbonates; Calcium Chloride; Cardioplegic Solutions; Dose-Response Relationship, Drug; Magnesium; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Potassium Chloride; Rats; Rats, Inbred Strains; Ribonucleosides; Sodium Chloride; Time Factors | 1992 |
Inhibition by AICA riboside of gluconeogenesis in isolated rat hepatocytes.
Topics: Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Dose-Response Relationship, Drug; Fructose-Bisphosphatase; Gluconeogenesis; In Vitro Techniques; Liver; Male; Nucleotides; Rats; Rats, Inbred Strains; Ribonucleosides; Time Factors | 1991 |
AICAriboside inhibits gluconeogenesis in isolated rat hepatocytes.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Fructose-Bisphosphatase; Gluconeogenesis; Hyperglycemia; In Vitro Techniques; Kinetics; Liver; Male; Rats; Rats, Inbred Strains; Ribonucleosides; Ribonucleotides | 1991 |
Alteration of purine metabolism by AICA-riboside in human B lymphoblasts.
Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; B-Lymphocytes; Cell Division; Cell Line; Humans; Phosphoribosyl Pyrophosphate; Purines; Ribonucleosides; Ribosemonophosphates | 1990 |
Z-nucleotides formation in human and rat cells.
Topics: Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Blood Platelets; Erythrocytes; Humans; In Vitro Techniques; Lymphocytes; Myocardium; Rats; Ribonucleosides; Ribonucleotides; Species Specificity | 1991 |
Regulation of adenosine concentrations by acadesine (AICA-riboside) in human B-lymphoblasts.
Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; B-Lymphocytes; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Kinetics; Ribonucleosides | 1991 |
Acadesine (AICA riboside) attenuates reperfusion injury and oxidant-induced damage of the heart.
Topics: Aminoimidazole Carboxamide; Animals; Guinea Pigs; Heart; In Vitro Techniques; Myocardium; Oxidants; Reperfusion Injury; Ribonucleosides | 1991 |
Acadesine (AICA riboside) inhibits platelet aggregation in human whole blood.
Topics: Adenosine Diphosphate; Aminoimidazole Carboxamide; Arachidonic Acid; Collagen; Dipyridamole; Humans; Platelet Aggregation; Platelet Aggregation Inhibitors; Ribonucleosides | 1991 |
5-Amino-4-imidazolecarboxamide riboside raises adenosine in perfused hypoxic rat heart.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Cardiac Output; Coronary Circulation; Heart; Hypoxia; Inosine; Male; Myocardium; Perfusion; Rats; Rats, Inbred Strains; Ribonucleosides | 1991 |
The use of 5-aminoimidazole-4-carboxamide riboside (AICA riboside) to improve random skin flap viability in the rat model.
Topics: Aminoimidazole Carboxamide; Animals; Graft Survival; Ischemia; Male; Models, Biological; Necrosis; Postoperative Care; Preoperative Care; Rats; Rats, Inbred Strains; Ribonucleosides; Skin; Skin Transplantation; Surgical Flaps | 1991 |
Antagonism of airway reactivity induced by ovalbumin antigen in guinea pigs by 5-amino-4-imidazolecarboxamide riboside.
Topics: Aminoimidazole Carboxamide; Analysis of Variance; Animals; Bronchial Hyperreactivity; Bronchial Spasm; Bronchoconstriction; Cromolyn Sodium; Guinea Pigs; Ovalbumin; Plethysmography, Whole Body; Ribonucleosides; Terbutaline | 1991 |
5-Aminoimidazole-4-carboxamide riboside (AICAr) administration reduces cerebral ischemic damage in the Mongolian gerbil.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Brain Ischemia; Gerbillinae; Hippocampus; Male; Motor Activity; Nerve Degeneration; Pyramidal Tracts; Ribonucleosides | 1990 |
Increased adenosine concentration in blood from ischemic myocardium by AICA riboside. Effects on flow, granulocytes, and injury.
Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Collateral Circulation; Coronary Circulation; Dogs; Granulocytes; Imidazoles; In Vitro Techniques; Myocardial Reperfusion Injury; Myocardium; Ribonucleosides; Superoxides | 1989 |
Purine nucleotide production in normal and HPRT- cells.
Topics: Aminoimidazole Carboxamide; Cells, Cultured; Folic Acid; Formates; Humans; Hypoxanthine Phosphoribosyltransferase; Purine Nucleotides; Ribonucleosides | 1989 |
Utility of AICAr for metabolic studies is diminished by systemic effects in situ.
Topics: Aminoimidazole Carboxamide; Animals; Blood Pressure; Energy Metabolism; Imidazoles; Magnetic Resonance Spectroscopy; Male; Muscle Contraction; Muscles; Rats; Rats, Inbred Strains; Ribonucleosides; Stimulation, Chemical | 1989 |
AICA-riboside: direct quantitation in ultrafiltrates of plasma by HPLC during pharmacokinetic studies in man.
Topics: Aminoimidazole Carboxamide; Chromatography, High Pressure Liquid; Humans; Imidazoles; Ribonucleosides; Ultrafiltration | 1989 |
Effect of 5-amino-4-imidazolecarboxamide riboside on renal ammoniagenesis. Study with [15N]aspartate.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; Ammonia; Animals; Aspartic Acid; Glutamates; Glutamic Acid; Imidazoles; Kidney; Lactates; Lactic Acid; Male; Models, Biological; Rats; Rats, Inbred Strains; Ribonucleosides | 1986 |
Effect of 5-amino-4-imidazolecarboxamide riboside (AICA-riboside) on the purine nucleotide synthesis and growth of rat kidney cells in culture: study with [15N]aspartate.
Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Animals; Aspartic Acid; Cell Division; Cell Line; DNA; Dose-Response Relationship, Drug; Imidazoles; Kidney; Purine Nucleotides; Rats; Ribonucleosides | 1989 |
Inhibition of mast cell mediator release by 5-amino-4-imidazolecarboxamide riboside.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; beta-N-Acetylhexosaminidases; Bone Marrow Cells; Calcimycin; Cells, Cultured; Imidazoles; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Ribonucleosides; SRS-A | 1986 |
Experimental studies on the effect of hepatoprotective compounds.
Topics: Aminoimidazole Carboxamide; Animals; Carbon Tetrachloride Poisoning; Catechin; Chemical and Drug Induced Liver Injury; Epoprostenol; Flavonoids; Galactosamine; Imidazoles; Liver; Liver Cirrhosis; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Inbred F344; Ribonucleosides; Silymarin | 1986 |
Free radicals in tissue damage in liver diseases and therapeutic approach.
Topics: Aminoimidazole Carboxamide; Antioxidants; Catechin; Flavonoids; Free Radicals; Humans; Imidazoles; Immunosuppressive Agents; Liver; Liver Cirrhosis; Lymphocyte Activation; Quinolines; Ribonucleosides; Silymarin; Superoxide Dismutase; Thiazoles | 1986 |
Dissociation between early recovery of regional function and purine nucleotide content in postischaemic myocardium in the conscious dog.
Topics: Aminoimidazole Carboxamide; Animals; Coronary Disease; Dogs; Heart; Hemodynamics; Myocardium; Nucleotides; Phosphocreatine; Purine Nucleotides; Ribonucleosides | 1987 |
Synthesis of carbocyclic purine nucleosides using key intermediates, carbocyclic AICA-ribosides.
Topics: Aminoimidazole Carboxamide; Indicators and Reagents; Methylation; Purine Nucleosides; Ribonucleosides | 1987 |
Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity.
Topics: Adenosine; Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Autistic Disorder; Chromatography, High Pressure Liquid; Creatinine; Ethylenediamines; Humans; Imidazoles; Lyases; Purine-Pyrimidine Metabolism, Inborn Errors; Reagent Strips; Ribonucleosides; Ribonucleotides; Spectrophotometry | 1986 |
Importance of purine nucleotide cycle to energy production in skeletal muscle.
Topics: Adenylosuccinate Lyase; Adenylosuccinate Synthase; Aerobiosis; Aminoimidazole Carboxamide; AMP Deaminase; Animals; Electric Stimulation; Energy Metabolism; Glycolysis; Muscle Contraction; Muscles; Phosphates; Physical Exertion; Purine Nucleotides; Rats; Ribonucleosides | 1986 |
Influence of ribose, adenosine, and "AICAR" on the rate of myocardial adenosine triphosphate synthesis during reperfusion after coronary artery occlusion in the dog.
Topics: Adenosine; Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Biopsy, Needle; Coronary Disease; Dogs; Drug Evaluation, Preclinical; Female; Heart; Hemodynamics; Imidazoles; Male; Myocardium; Perfusion; Ribonucleosides; Ribose; Time Factors | 1985 |
5-Amino-4-imidazolecarboxamide riboside (Z-riboside) metabolism in eukaryotic cells.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Cricetinae; Cricetulus; Female; Fibroblasts; Imidazoles; Inosine Monophosphate; Ovary; Purine Nucleotides; Pyrimidine Nucleotides; Ribonucleosides; Ribonucleotides | 1985 |
[Effect of AICAriboside on the protection of the ischemic myocardium and its mechanism of action].
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Coronary Disease; Cricetinae; Cytidine Triphosphate; Dogs; Guanosine Triphosphate; Heart; Imidazoles; Myocardium; Ribonucleosides | 1985 |
Protective effects of AICAriboside in the globally ischemic isolated cat heart.
Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Animals; Cats; Coronary Circulation; Coronary Disease; Female; Heart Rate; Imidazoles; Male; Myocardial Contraction; Myocardium; Ribonucleosides | 1985 |
Aminoimidazole carboxamide ribonucleoside toxicity: a model for study of pyrimidine starvation.
Topics: Aminoimidazole Carboxamide; Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Fibroblasts; Imidazoles; Lung; Models, Biological; Pentosephosphates; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Ribonucleosides | 1981 |
The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP).
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Cell Line; Cricetinae; Imidazoles; Kinetics; Phosphoribosyl Pyrophosphate; Phosphorylation; Ribonucleosides; Ribonucleotides; Ribose-Phosphate Pyrophosphokinase; Substrate Specificity | 1984 |
Disruption of the purine nucleotide cycle by inhibition of adenylosuccinate lyase produces skeletal muscle dysfunction.
Topics: Adenylosuccinate Lyase; Aminoimidazole Carboxamide; Animals; Lyases; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscles; Phosphocreatine; Purine Nucleotides; Ribonucleosides; Ribonucleotides | 1984 |
The in vivo and in vitro action of 4-amino-5-imidazolecarboxamide in trypanosomatid flagellates.
Topics: Aminoimidazole Carboxamide; Animals; Guanine Deaminase; Imidazoles; Leishmania; Ribonucleosides; Trypanosoma cruzi | 1981 |
Accelerated repletion of ATP and GTP pools in postischemic canine myocardium using a precursor of purine de novo synthesis.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Coronary Disease; Dogs; Dose-Response Relationship, Drug; Guanosine Triphosphate; Imidazoles; Myocardium; Ribonucleosides | 1982 |
Enhancement of adenosine A1 receptor functions by benzoylthiophenes in guinea pig tissues in vitro.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Electric Stimulation; Guinea Pigs; Heart Atria; Ileum; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Male; Muscle Contraction; Myocardial Contraction; Peptides; Purinergic P1 Receptor Agonists; Purinergic P1 Receptor Antagonists; Pyridines; Receptors, Purinergic P1; Ribonucleosides; Thienopyridines; Thiophenes; Wasp Venoms | 1995 |
Effect of acadesine treatment on postischemic damage to small intestine.
Topics: Aminoimidazole Carboxamide; Animals; Cats; Cell Movement; Female; Glutathione; Intestinal Mucosa; Intestine, Small; Ischemia; Lipid Peroxides; Male; Neutrophils; Peroxidase; Purines; Reperfusion Injury; Ribonucleosides | 1995 |
Acadesine extends the window of protection afforded by ischaemic preconditioning in conscious rabbits.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Time Factors; Ventricular Fibrillation | 1995 |
Insulinotropic action of AICA riboside. I. Insulin release by isolated islets and the perfused pancreas.
Topics: Aminoimidazole Carboxamide; Animals; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Pancreas; Perfusion; Rats; Rats, Wistar; Ribonucleosides; Time Factors | 1994 |
Insulinotropic action of AICA riboside. II. Secretory, metabolic and cationic aspects.
Topics: Adenine Nucleotides; Amino Acids; Aminoimidazole Carboxamide; Animals; Calcium; Egtazic Acid; Female; Glucose; Glycolysis; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Membrane Potentials; Methotrexate; Mice; Mice, Inbred Strains; Patch-Clamp Techniques; Rats; Rats, Wistar; Ribonucleosides; Rubidium; Time Factors | 1994 |
Adenosine activates A2 receptors to inhibit neutrophil adhesion and injury to isolated cardiac myocytes.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Cell Adhesion; Cells, Cultured; Dogs; Heart Injuries; Myocardium; Neutrophils; Receptors, Purinergic P1; Ribonucleosides | 1995 |
Resuscitation of hemorrhagic shock with hypertonic saline/dextran or lactated Ringer's supplemented with AICA riboside.
Topics: Aminoimidazole Carboxamide; Animals; Buffers; Dextrans; Disease Models, Animal; Female; Hemodynamics; Hypertonic Solutions; Lactates; Male; Oxygen Consumption; Reperfusion Injury; Ribonucleosides; Shock, Hemorrhagic; Sodium Chloride; Swine | 1993 |
Inhibition of fatty acid and cholesterol synthesis by stimulation of AMP-activated protein kinase.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Cholesterol; Enzyme Activation; Fatty Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Liver; Male; Multienzyme Complexes; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleosides; Ribonucleotides | 1995 |
Role of acadesine in clinical myocardial protection.
Topics: Aminoimidazole Carboxamide; Clinical Trials as Topic; Humans; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Ribonucleosides | 1995 |
Acadesine reduces myocardial infarct size by an adenosine mediated mechanism.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Extracellular Space; In Vitro Techniques; Male; Myocardial Infarction; Myocardial Reperfusion; Myocardium; Rabbits; Receptors, Purinergic P1; Regional Blood Flow; Ribonucleosides; Theophylline | 1995 |
Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography.
Topics: Acyltransferases; Aminoimidazole Carboxamide; Chromatography, Thin Layer; Hydroxymethyl and Formyl Transferases; Indicators and Reagents; Inosine Monophosphate; Kinetics; Nucleotide Deaminases; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphorylation; Phosphotransferases; Radioisotope Dilution Technique; Ribonucleosides; Ribonucleotides; Sensitivity and Specificity; Serratia marcescens; Time Factors; Tritium | 1994 |
Acadesine improves tolerance to ischemic injury in rat cardiac myocytes.
Topics: Aminoimidazole Carboxamide; Animals; Disease Models, Animal; Female; Heart; In Vitro Techniques; Myocardial Contraction; Myocardial Reperfusion Injury; Purinergic P1 Receptor Antagonists; Rats; Rats, Sprague-Dawley; Ribonucleosides; Theophylline | 1994 |
Spectrophotometric determination of acadesine (AICA-riboside) in plasma using a diazotization coupling technique with N-(1-naphthyl)ethylenediamine.
Topics: Aminoimidazole Carboxamide; Azo Compounds; Cardiotonic Agents; Chromatography, High Pressure Liquid; Colorimetry; Coronary Artery Bypass; Ethylenediamines; Humans; Indicators and Reagents; Infusions, Intravenous; Ribonucleosides; Sensitivity and Specificity; Spectrophotometry | 1994 |
Acadesine reduces indium-labeled platelet deposition after photothrombosis of the common carotid artery in rats.
Topics: Aminoimidazole Carboxamide; Animals; Blood Platelets; Carotid Artery Injuries; Carotid Artery Thrombosis; Carotid Artery, Common; Cerebral Infarction; Indium Radioisotopes; Intracranial Embolism and Thrombosis; Lasers; Male; Rats; Rats, Wistar; Ribonucleosides | 1995 |
Cell-type specificity of inhibition of glycolysis by 5-amino-4-imidazolecarboxamide riboside. Lack of effect in rabbit cardiomyocytes and human erythrocytes, and inhibition in FTO-2B rat hepatoma cells.
Topics: Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Dihydroxyacetone; Erythrocytes; Fructosephosphates; Glucose-6-Phosphate; Glucosephosphates; Glycolysis; Humans; Lactates; Lactic Acid; Liver Neoplasms, Experimental; Male; Myocardium; Rabbits; Rats; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured | 1995 |
Adenosine-mediated inhibition of platelet aggregation by acadesine. A novel antithrombotic mechanism in vitro and in vivo.
Topics: Adenosine; Adenosine Deaminase; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Aspirin; Blood Physiological Phenomena; Coronary Thrombosis; Coronary Vessels; Dipyridamole; Disease Models, Animal; Dogs; Erythrocytes; Humans; Male; Plasma; Platelet Aggregation; Purinergic P1 Receptor Antagonists; Regional Blood Flow; Ribonucleosides; Theophylline; Tubercidin | 1994 |
AICA riboside improves myocardial ischemia in coronary microembolization in dogs.
Topics: 5'-Nucleotidase; Adenine Nucleotides; Adenosine; Aminoimidazole Carboxamide; Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Cytosol; Dogs; Energy Metabolism; Myocardial Ischemia; Myocardium; Oxygen Consumption; Ribonucleosides; Thromboembolism | 1994 |
Timely administration of AICA riboside reduces reperfusion injury in rabbits.
Topics: Aminoimidazole Carboxamide; Animals; Autoradiography; Disease Models, Animal; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Rabbits; Ribonucleosides; Tetrazolium Salts | 1994 |
An initial multicenter, randomized controlled trial on the safety and efficacy of acadesine in patients undergoing coronary artery bypass graft surgery.
Topics: Aminoimidazole Carboxamide; Coronary Artery Bypass; Heart; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Ribonucleosides | 1994 |
Adenosine and AICA-riboside fail to enhance microvascular endothelial preservation.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Blood; Bradykinin; Calcimycin; Cardioplegic Solutions; Cardiopulmonary Bypass; Coronary Vessels; Endothelium, Vascular; Female; Heart Arrest, Induced; Male; Muscle, Smooth, Vascular; Myocardial Reperfusion Injury; Nitroprusside; Ribonucleosides; Swine | 1994 |
Control of lactate utilization by extracellular pH in isolated rat liver cells.
Topics: Aminoimidazole Carboxamide; Animals; Cell Separation; Eating; Extracellular Space; Fasting; Glucose; Glycolysis; Hydrogen-Ion Concentration; Lactates; Lactic Acid; Liver; Male; Rats; Rats, Wistar; Ribonucleosides | 1994 |
Acadesine extends the window of protection afforded by ischaemic preconditioning.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rabbits; Ribonucleosides; Theophylline; Time Factors | 1994 |
Infection of soybean and pea nodules by Rhizobium spp. purine auxotrophs in the presence of 5-aminoimidazole-4-carboxamide riboside.
Topics: Aminoimidazole Carboxamide; Fabaceae; Mutagenesis; Plants, Medicinal; Purines; Rhizobium; Ribonucleosides; Species Specificity; Symbiosis | 1994 |
Acadesine improves surgical myocardial protection with blood cardioplegia in ischemically injured canine hearts.
Topics: Aminoimidazole Carboxamide; Animals; Blood; Dogs; Dose-Response Relationship, Drug; Heart Arrest, Induced; Myocardial Contraction; Myocardial Reperfusion Injury; Premedication; Ribonucleosides; Time Factors; Ventricular Function, Left | 1993 |
Acadesine (AICA-riboside): disposition and metabolism of an adenosine-regulating agent.
Topics: Adult; Aminoimidazole Carboxamide; Carbon Radioisotopes; Half-Life; Humans; Infusions, Intravenous; Male; Purines; Ribonucleosides; Saliva; Uric Acid | 1993 |
5-Amino-4-imidazolecarboxamide riboside potentiates the metabolism and anti-human immunodeficiency virus activity of 2',3'-dideoxyinosine.
Topics: Aminoimidazole Carboxamide; Cells, Cultured; Didanosine; Drug Synergism; HIV; Humans; Inosine Monophosphate; Nucleotides; Phosphorylation; Polymerase Chain Reaction; Ribonucleosides; T-Lymphocytes; Transcription, Genetic; Virus Replication | 1993 |
Reversal of 6-mercaptopurine and 6-methylmercaptopurine ribonucleoside cytotoxicity by amidoimidazole carboxamide ribonucleoside in Molt F4 human malignant T-lymphoblasts.
Topics: Adenine Nucleotides; Aminoimidazole Carboxamide; Cell Count; Cell Death; Drug Interactions; Guanine Nucleotides; Humans; Mercaptopurine; Methylthioinosine; Ribonucleosides; Thioinosine; Thionucleosides; Thionucleotides; Time Factors; Tumor Cells, Cultured | 1993 |
Acadesine prevents oxidant-induced damage in the isolated guinea pig heart.
Topics: Aminoimidazole Carboxamide; Animals; Antioxidants; Guinea Pigs; Heart; Hypochlorous Acid; Imidazoles; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Reactive Oxygen Species; Ribonucleosides | 1993 |
Acadesine lowers temporal threshold for the myocardial infarct size limiting effect of preconditioning.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Female; Male; Myocardial Infarction; Myocardial Ischemia; Myocardium; Rabbits; Receptors, Purinergic; Ribonucleosides; Time Factors | 1993 |
Acadesine reduces the frequency of coronary artery reocclusion following rt-PA induced thrombolysis in the dog.
Topics: Aminoimidazole Carboxamide; Animals; Coronary Disease; Dogs; Fibrinolytic Agents; Male; Perfusion; Recombinant Proteins; Ribonucleosides; Tissue Plasminogen Activator | 1995 |
Acadesine and lipopolysaccharide-evoked pulmonary dysfunction after resuscitation from traumatic shock.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Capillary Permeability; Hydrocortisone; Leukocyte Count; Lipopolysaccharides; Lung; Resuscitation; Ribonucleosides; Shock, Traumatic; Swine; Tumor Necrosis Factor-alpha | 1996 |
Effects of OG-VI, a nucleoside/nucleotide mixture, and its constituents on myocardial stunning in dogs.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Carbohydrate Metabolism; Dogs; Energy Metabolism; Female; Heart; Hemodynamics; Male; Myocardial Stunning; Myocardium; Nucleosides; Nucleotides; Ribonucleosides | 1995 |
Potentiation of excitatory amino acid-evoked adenosine release from rat cortex by inhibitors of adenosine kinase and adenosine deaminase and by acadesine.
Topics: Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoimidazole Carboxamide; Animals; Cerebral Cortex; Drug Synergism; Excitatory Amino Acid Agonists; In Vitro Techniques; Kainic Acid; Male; N-Methylaspartate; Rats; Rats, Sprague-Dawley; Ribonucleosides | 1996 |
Substrate cycling between 5-amino-4-imidazolecarboxamide riboside and its monophosphate in isolated rat hepatocytes.
Topics: Aminoimidazole Carboxamide; Animals; Dose-Response Relationship, Drug; Liver; Male; Purine Nucleotides; Rats; Rats, Wistar; Ribonucleosides; Time Factors | 1996 |
Involvement of purine nucleotide synthetic pathways in gonadotropin-induced meiotic maturation in mouse cumulus cell-enclosed oocytes.
Topics: Aminoimidazole Carboxamide; Animals; Azaserine; Chromatography, High Pressure Liquid; Cyclic AMP; Follicle Stimulating Hormone; Hypoxanthine; Meiosis; Mice; Mice, Inbred C57BL; Oocytes; Oogenesis; Purines; Ribonucleosides; Signal Transduction | 1997 |
Adenosine and K(+)-induced Ca2+ loading.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Calcium; Cardioplegic Solutions; Humans; Myocardial Reperfusion Injury; Myocardium; Potassium; Ribonucleosides | 1997 |
AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle.
Topics: Acetyl-CoA Carboxylase; Adenine Nucleotides; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cattle; Enzyme Activation; Erythrocytes; Glucose; Hindlimb; Insulin; Kinetics; Male; Malonyl Coenzyme A; Multienzyme Complexes; Muscle, Skeletal; Palmitic Acid; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleosides; Ribonucleotides; Serum Albumin, Bovine | 1997 |
CASP2 molecular docking predictions with the LIGIN software.
Topics: Amiloride; Aminoimidazole Carboxamide; Arabinose; Concanavalin A; Enzyme Inhibitors; Fructose-Bisphosphatase; Humans; Ligands; Molecular Structure; Pancreatic Elastase; Pentamidine; Protein Conformation; Proteins; Ribonucleosides; Software; Trypsin | 1997 |
CASP2 experiences with docking flexible ligands using FlexX.
Topics: Amiloride; Aminoimidazole Carboxamide; Arabinose; Concanavalin A; Fructose-Bisphosphatase; Ligands; Models, Molecular; Pancreatic Elastase; Pentamidine; Protein Conformation; Proteins; Ribonucleosides; Software; Trypsin | 1997 |
Dual regulation of the AMP-activated protein kinase provides a novel mechanism for the control of creatine kinase in skeletal muscle.
Topics: Amino Acid Sequence; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Clone Cells; Creatine; Creatine Kinase; Enzyme Inhibitors; Hydrogen-Ion Concentration; Liver; Models, Chemical; Molecular Sequence Data; Multienzyme Complexes; Muscle Fibers, Skeletal; Muscle, Skeletal; Phosphocreatine; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rabbits; Rats; Ribonucleosides | 1998 |
AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Fatty Acid Synthases; Female; Gene Expression Regulation; Glucokinase; Glucose; Liver; Nucleotides; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Rats; Rats, Wistar; Ribonucleosides; Transcriptional Activation | 1998 |
Acadesine increases blood flow in the collateralized heart during exercise.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Collateral Circulation; Coronary Circulation; Dogs; Female; Heart; Hemodynamics; Infusions, Intravenous; Male; Myocardial Ischemia; Physical Conditioning, Animal; Ribonucleosides | 1998 |
Endogenous adenosine reduces the occurrence of ischemia-induced ventricular fibrillation in rat heart.
Topics: Adenine; Adenosine; Aminoimidazole Carboxamide; Animals; Caffeine; Creatine Kinase; Electrocardiography; Enzyme Inhibitors; Hypoxanthine; Inosine; Male; Myocardial Ischemia; Myocardium; Perfusion; Rats; Rats, Wistar; Reperfusion Injury; Ribonucleosides; Theophylline; Thioinosine; Thiophenes; Time Factors; Ventricular Fibrillation; Xanthines | 1999 |
The unorthodox and orthodox: the therapeutic role of acadesine after traumatic injury and sepsis.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Hemodynamics; Humans; Microcirculation; Ribonucleosides; Sepsis; Shock, Hemorrhagic; Swine; Wounds and Injuries | 1999 |
5' AMP-activated protein kinase activation causes GLUT4 translocation in skeletal muscle.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Cell Membrane; Enzyme Activation; Fructosephosphates; Glucose; Glucose Transporter Type 4; Glucose-6-Phosphate; Hindlimb; Insulin; Intracellular Membranes; Male; Monosaccharide Transport Proteins; Multienzyme Complexes; Muscle Proteins; Muscle, Skeletal; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleosides | 1999 |
Improvement by 5-amino-4-imidazole carboxamide riboside of the contractile dysfunction that follows brief periods of ischemia through increases in ecto-5-nucleotidase activity and adenosine release in canine hearts.
Topics: 5'-Nucleotidase; Adenosine; Aminoimidazole Carboxamide; Animals; Dogs; Hemodynamics; Myocardial Contraction; Myocardial Ischemia; Myocardium; Purinergic P1 Receptor Antagonists; Reperfusion; Ribonucleosides | 1999 |
Effects of adenosine and acadesine on interstitial nucleosides and myocardial stunning in the pig.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Circulation; Extracellular Space; Female; Heart; Male; Myocardial Stunning; Perfusion; Renal Dialysis; Ribonucleosides; Swine | 1999 |
5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Gene Expression; Gluconeogenesis; Glucose-6-Phosphatase; Insulin; Multienzyme Complexes; Phosphoenolpyruvate Carboxykinase (GTP); Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Transcription, Genetic; Tumor Cells, Cultured | 2000 |
The rate of cell growth is regulated by purine biosynthesis via ATP production and G(1) to S phase transition.
Topics: Adenosine Triphosphate; Amidophosphoribosyltransferase; Aminoimidazole Carboxamide; Animals; Cell Cycle; Cell Division; CHO Cells; Cricetinae; Cricetulus; Culture Media; G1 Phase; Guanosine Triphosphate; Hypoxanthine; Hypoxanthine Phosphoribosyltransferase; Nucleotidyltransferases; Purines; Pyrimidines; Ribonucleosides; S Phase | 2000 |
Cytosolic 5'-nucleotidase hyperactivity in erythrocytes of Lesch-Nyhan syndrome patients.
Topics: 5'-Nucleotidase; Adolescent; Adult; Aminoimidazole Carboxamide; Animals; Apoptosis; Autistic Disorder; Child; Cytosol; Erythrocytes; Female; Humans; Hypoxanthine Phosphoribosyltransferase; Lesch-Nyhan Syndrome; Male; Mice; Middle Aged; Nervous System Diseases; Reference Values; Ribonucleosides; Ribonucleotides; Tumor Cells, Cultured; Uric Acid | 2000 |
Endogenous adenosine and secondary injury after chest trauma.
Topics: Acidosis; Adenosine; Aminoimidazole Carboxamide; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Hemodynamics; Hypercapnia; Inflammation; Leukocyte Count; Peroxidase; Ribonucleosides; Survival Analysis; Swine; Thoracic Injuries; Wounds, Nonpenetrating | 2000 |
Acadesine and intestinal barrier function after hemorrhagic shock and resuscitation.
Topics: Adenosine; Adenosine Kinase; Aminoimidazole Carboxamide; Animals; Blood Flow Velocity; Capillary Permeability; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Fluid Therapy; Formycins; Ileum; Intestinal Mucosa; Ischemia; Laser-Doppler Flowmetry; Male; Resuscitation; Ribonucleosides; Shock, Hemorrhagic; Swine | 2000 |
The protective effect of acadesine on lung ischemia-reperfusion injury.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Blood Pressure; Cats; Ischemia; Lung; Reperfusion Injury; Ribonucleosides | 2001 |
Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell.
Topics: Acetyl-CoA Carboxylase; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Cells, Cultured; Glucose; Glutamic Acid; Humans; Islets of Langerhans; Magnesium; Male; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rats; Ribonucleosides | 2001 |
5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Binding Sites; Biological Transport; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Glucose; Humans; Insulin; Insulin Receptor Substrate Proteins; Mice; Multienzyme Complexes; Muscle, Skeletal; Myocardium; Peptides; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Recombinant Proteins; Ribonucleosides; Serine; Signal Transduction; Subcellular Fractions; Time Factors | 2001 |
Effect of 5-aminoimidazole-4-carboxamide riboside (AICA-r) on isolated thoracic aorta responses in streptozotocin-diabetic rats.
Topics: Acetylcholine; Aminoimidazole Carboxamide; Animals; Aorta, Thoracic; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Endothelium, Vascular; Female; Injections, Intraperitoneal; Male; Nitroprusside; Norepinephrine; Rats; Rats, Wistar; Ribonucleosides; Vasoconstriction; Vasodilation | 2001 |
Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animal Feed; Animals; Deoxyglucose; Glycogen; Glycogen Synthase; Isoenzymes; Male; Motor Activity; Multienzyme Complexes; Muscle, Skeletal; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleosides; Ribonucleotides; Swimming | 2002 |
Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells.
Topics: Adenoviridae; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Blotting, Western; Cell Line; Deoxyglucose; Enzyme Activation; Glucose; Heterozygote; Insulin; Mice; Mice, Transgenic; Multienzyme Complexes; Muscle, Skeletal; Osmosis; Physical Conditioning, Animal; Protein Serine-Threonine Kinases; Ribonucleosides | 2002 |
Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Electric Stimulation; Enzyme Activation; In Vitro Techniques; Male; Multienzyme Complexes; Muscle Contraction; Muscle, Skeletal; Physical Conditioning, Animal; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleosides; Swimming; Transcription Factors | 2002 |
Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Hypoxia; Cell Line; Deoxyglucose; Enzyme Activation; Enzyme Inhibitors; Hepatocytes; Humans; Multienzyme Complexes; Oligomycins; Oxygen; Peptide Chain Elongation, Translational; Peptide Elongation Factor 2; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Signal Transduction; TOR Serine-Threonine Kinases | 2002 |
Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Kinetics; Multienzyme Complexes; Muscle, Skeletal; Protein Kinases; Protein Serine-Threonine Kinases; Ribonucleosides; Ribonucleotides | 2002 |
5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved.
Topics: Adenosine; Affinity Labels; Amino Acid Chloromethyl Ketones; Aminoimidazole Carboxamide; Apoptosis; Caspases; Cyclic AMP-Dependent Protein Kinases; Cytochrome c Group; Enzyme Inhibitors; Humans; Jurkat Cells; Phosphorylation; Ribonucleosides; Thioinosine | 2003 |
Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes.
Topics: Adenosine; Amino Acid Chloromethyl Ketones; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antimetabolites, Antineoplastic; Apoptosis; B-Lymphocytes; Caspases; Cyclic AMP-Dependent Protein Kinases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Ribonucleosides; Ribonucleotides; T-Lymphocytes; Tubercidin; Tumor Cells, Cultured | 2003 |
AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Enzyme Activation; Islets of Langerhans; Mice; Multienzyme Complexes; Protein Serine-Threonine Kinases; Rats; Ribonucleosides | 2003 |
5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.
Topics: 5'-Nucleotidase; Acetylcholine; Aminoimidazole Carboxamide; Apoptosis; Brain; Caspase 3; Caspases; Cell Differentiation; Cells, Cultured; Dipyridamole; Enzyme Inhibitors; Humans; Lesch-Nyhan Syndrome; Neuroblastoma; Neurons; Norepinephrine; Phorbol Esters; Proto-Oncogene Proteins c-bcl-2; Purines; Ribonucleosides; Ribose-Phosphate Pyrophosphokinase; Tretinoin | 2003 |
AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Chloromethyl Ketones; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Carrier Proteins; Caspase 3; Caspases; Cell Line; Dicumarol; Enzyme Activation; Enzyme Inhibitors; Glucose; Insulin; Islets of Langerhans; JNK Mitogen-Activated Protein Kinases; Mice; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Protein Serine-Threonine Kinases; Rats; Recombinant Fusion Proteins; Ribonucleosides | 2003 |
Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.
Topics: Aminoimidazole Carboxamide; Animals; Bucladesine; Cell-Free System; Enzyme Inhibitors; Flavanones; Flavonoids; Glycine; Glycine N-Methyltransferase; Hepatocytes; Methyltransferases; Okadaic Acid; Peptide Fragments; Phosphorylation; Rats; Ribonucleosides; S-Adenosylhomocysteine; S-Adenosylmethionine | 2003 |
AMP-activated protein kinase plays a role in the control of food intake.
Topics: Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Appetite Regulation; Blotting, Western; Brain; Eating; Ghrelin; Hypothalamus; Intercellular Signaling Peptides and Proteins; Leptin; Liver; Multienzyme Complexes; Muscles; Peptide Hormones; Peptide YY; Protein Serine-Threonine Kinases; Proteins; Rats; Rats, Wistar; Ribonucleosides; Time Factors | 2004 |
AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Hippocampus; Humans; In Vitro Techniques; Male; Multienzyme Complexes; Nucleoside Transport Proteins; Nucleotides; Protein Serine-Threonine Kinases; Rats; Receptors, Purinergic P1; Ribonucleosides; Stress, Physiological; Synaptic Transmission | 2004 |
Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Fasting; Glucose; Glycogen; Hyperinsulinism; Hypoglycemic Agents; Hypothalamus; Injections, Intraventricular; Insulin; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Muscle, Skeletal; Phosphorylation; Protein Serine-Threonine Kinases; Ribonucleosides | 2004 |
5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport, Active; Enzyme Activation; Glucose; Glucose Transporter Type 2; Imidazoles; Intestinal Mucosa; Jejunum; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Monosaccharide Transport Proteins; Multienzyme Complexes; p38 Mitogen-Activated Protein Kinases; Protein Serine-Threonine Kinases; Protein Transport; Pyridines; Ribonucleosides; RNA, Messenger; Sodium-Glucose Transporter 1 | 2005 |
Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma.
Topics: Aminoimidazole Carboxamide; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Humans; In Vitro Techniques; Lymphoma; Lymphoma, Mantle-Cell; Ribonucleosides; Splenic Neoplasms | 2005 |
AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line.
Topics: Adenosine Triphosphate; Adenoviridae; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aryl Hydrocarbon Hydroxylases; Barbiturates; beta-Galactosidase; Blotting, Western; Cell Line, Tumor; Cells, Cultured; Constitutive Androstane Receptor; Culture Media; Cytochrome P-450 CYP2B1; Cytochrome P-450 CYP2B6; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Genes, Dominant; Genes, Reporter; Hepatocytes; Humans; Male; Mice; Multienzyme Complexes; Oxidoreductases, N-Demethylating; Phenobarbital; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleosides; RNA; RNA, Messenger; Transcription Factors; Transcription, Genetic | 2005 |
Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase.
Topics: Adenosine Triphosphate; Adenylosuccinate Synthase; Aminoimidazole Carboxamide; Aspartic Acid; Bacterial Proteins; Chromatography, High Pressure Liquid; Cloning, Molecular; Enzyme Inhibitors; Escherichia coli Proteins; Hydrogen-Ion Concentration; Inosine Monophosphate; Kinetics; Magnesium; Manganese; Models, Chemical; Peptide Synthases; Recombinant Proteins; Ribonucleosides; Substrate Specificity | 2005 |
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype.
Topics: Adenosine Monophosphate; Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Biomimetic Materials; Breast Neoplasms; Cell Growth Processes; Cell Line, Tumor; Cell Movement; Cell Survival; Energy Metabolism; Female; Humans; Male; Mice; Mice, Nude; Prostatic Neoplasms; Ribonucleosides; Ribonucleotides; Xenograft Model Antitumor Assays | 2005 |
5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; ATP-Binding Cassette Transporters; Calcium; Drug Synergism; Enzyme Activation; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Mice; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Proteins; Multienzyme Complexes; Potassium Channels; Potassium Channels, Inwardly Rectifying; Protein Serine-Threonine Kinases; Receptors, Drug; Ribonucleosides; Sulfonylurea Receptors | 2005 |
Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes.
Topics: 3T3-L1 Cells; Adenosine Monophosphate; Adenosine Triphosphate; Adenoviridae; Adipocytes; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Catalysis; Cyclic AMP; Enzyme Activation; Gene Deletion; Genes, Dominant; Humans; Immunoprecipitation; Lipid Metabolism; Lipids; Lipolysis; Male; Mice; Mice, Knockout; Multienzyme Complexes; Phenformin; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleosides; Time Factors | 2005 |
AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells.
Topics: Aminoimidazole Carboxamide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Glycogen Synthase Kinase 3; Humans; Interleukin-2; Jurkat Cells; NFATC Transcription Factors; Nuclear Proteins; Phosphorylation; Ribonucleosides; Signal Transduction; Transcription Factors | 2005 |
Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Dose-Response Relationship, Drug; Enzyme Activation; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Myocardium; Protein Serine-Threonine Kinases; Ribonucleosides | 2006 |
α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; Deoxyglucose; Enzyme Activation; Glucose; Glucose Transporter Type 4; Insulin; Isoenzymes; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Muscle, Skeletal; Physical Conditioning, Animal; Protein Serine-Threonine Kinases; Ribonucleosides; Up-Regulation | 2006 |
Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 1; Enzyme Activation; Glucose; Hormones; Hypoglycemia; Hypothalamus, Middle; Male; Multienzyme Complexes; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleosides; Sodium Chloride | 2006 |
Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway.
Topics: Adiponectin; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Blotting, Western; Bucladesine; Cells, Cultured; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Endothelial Cells; Enzyme Activation; Glucose; Humans; Hydrogen Peroxide; Isoquinolines; Lipoproteins, LDL; Multienzyme Complexes; Protein Serine-Threonine Kinases; Reactive Oxygen Species; Recombinant Proteins; Ribonucleosides; Signal Transduction; Sulfonamides | 2006 |
AMPK or ZMPK?
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; Enzyme Activation; Humans; Isopentenyladenosine; Metformin; Models, Biological; Phosphorylation; Protein Kinases; Ribonucleosides; Ribonucleotides | 2006 |
Diagnosing AICA-ribosiduria by capillary electrophoresis.
Topics: Adult; Aminoimidazole Carboxamide; Electrophoresis, Capillary; Female; Humans; Male; Metabolism, Inborn Errors; Middle Aged; Ribonucleosides | 2006 |
Moving preconditioning from bench to bedside.
Topics: Adenosine; Aminoimidazole Carboxamide; Animals; Coronary Artery Bypass; Humans; Ischemic Preconditioning, Myocardial; Myocardial Infarction; Myocardial Reperfusion Injury; Ribonucleosides; Survival Rate | 2006 |
Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Breast Neoplasms; Carcinoma, Squamous Cell; Cell Line, Tumor; DNA, Neoplasm; Drug Synergism; Enzyme Activation; Humans; Lipids; Methotrexate; Multienzyme Complexes; Nucleotide Deaminases; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Protein Serine-Threonine Kinases; Purines; Ribonucleosides; Ribonucleotides; RNA Interference | 2006 |
A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cells, Cultured; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose; Hypertrophy; Intracellular Signaling Peptides and Proteins; Kidney; Metformin; Multienzyme Complexes; Phosphoproteins; Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Transforming Growth Factor beta | 2007 |
Analysis of intracellular nucleotides by capillary electrophoresis-mass spectrometry.
Topics: Aminoimidazole Carboxamide; Electrophoresis, Capillary; Erythrocytes; Humans; Hydrogen-Ion Concentration; Mass Spectrometry; Nucleotides; Purines; Ribonucleosides | 2006 |
Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway.
Topics: Aminoimidazole Carboxamide; Biochemistry; Ions; Mass Spectrometry; Models, Chemical; Molecular Structure; Purines; Ribonucleosides | 2006 |
5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway.
Topics: Aminoimidazole Carboxamide; Apoptosis; Caspase 9; Cell Line, Tumor; Cell Survival; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Fluorescent Dyes; Humans; Metformin; Mitochondria; Neuroblastoma; Purines; Ribonucleosides; Tetrazolium Salts; Thiazoles | 2006 |
Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Dose-Response Relationship, Drug; Enzyme Activation; Glucose; Glycogen; Glycogen Phosphorylase; Glycogen Synthase; Glycolysis; In Vitro Techniques; Insulin; Lactic Acid; Male; Multienzyme Complexes; Muscle Contraction; Muscle, Skeletal; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleosides; Ribonucleotides; Time Factors | 2007 |
Covariate heterogeneity in meta-analysis: criteria for deciding between meta-regression and individual patient data.
Topics: Aminoimidazole Carboxamide; BCG Vaccine; Cholesterol; Clinical Trials as Topic; Coronary Artery Bypass; Female; Fibrosis; Hemorrhage; Humans; Male; Meta-Analysis as Topic; Regression Analysis; Ribonucleosides | 2007 |
Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Apoptosis; Cell Cycle; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p21; Deoxyglucose; DNA-Binding Proteins; Down-Regulation; Energy Metabolism; Female; HeLa Cells; Human papillomavirus 18; Humans; Multienzyme Complexes; Oncogene Proteins, Viral; Protein Serine-Threonine Kinases; Ribonucleosides; RNA, Small Interfering; Transcription Factor AP-1; Transcription, Genetic; Tumor Suppressor Protein p53; Uterine Cervical Neoplasms | 2007 |
AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Coformycin; Dose-Response Relationship, Drug; Electron Transport Complex I; Enzyme Activation; Enzyme Inhibitors; Fructose; Hepatocytes; Humans; Hypoglycemic Agents; Liver; Male; Mice; Mice, Knockout; Mice, Transgenic; Mitochondria, Liver; Multienzyme Complexes; Oxidative Phosphorylation; Oxygen; Protein Serine-Threonine Kinases; Protein Subunits; Rats; Rats, Wistar; Ribonucleosides | 2007 |
Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism.
Topics: Adenine; Adenosine; Adenosine Deaminase; Adenosine Deaminase Inhibitors; Aminoimidazole Carboxamide; Animals; Antirheumatic Agents; Arthritis, Experimental; Biomarkers; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Methotrexate; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Rats; Ribonucleosides | 2007 |
5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Cell Cycle; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Multienzyme Complexes; NF-kappa B; Protein Serine-Threonine Kinases; Ribonucleosides; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha | 2007 |
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase.
Topics: Adenosine Kinase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Electrophoretic Mobility Shift Assay; Enzyme Activation; Gene Expression; Genes, Reporter; Inflammation; Lipopolysaccharides; Macrophages; Mice; Microglia; Multienzyme Complexes; Nitric Oxide Synthase Type II; Protein Binding; Protein Serine-Threonine Kinases; Ribonucleosides; RNA, Messenger; Signal Transduction; Transcription Factors; Transcription, Genetic | 2008 |
5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Catecholamines; Chromaffin Cells; Cyclic AMP; Dopamine; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Models, Biological; Multienzyme Complexes; PC12 Cells; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Tyrosine 3-Monooxygenase | 2007 |
A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation.
Topics: Acetyl-CoA Carboxylase; Actins; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Animals, Newborn; Astrocytes; Cell Size; Cells, Cultured; Cerebral Cortex; Cyclic AMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Green Fluorescent Proteins; Multienzyme Complexes; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Ribonucleosides; Time Factors; Transfection; Xanthines | 2007 |
The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; ATP-Binding Cassette Transporters; Cells, Cultured; Enzyme Activators; Glucose; L-Lactate Dehydrogenase; Lactic Acid; Male; Monocarboxylic Acid Transporters; Multienzyme Complexes; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Ribonucleosides; Sertoli Cells | 2007 |
Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling.
Topics: Adenosine; Aminoimidazole Carboxamide; Biomarkers, Tumor; Breast Neoplasms; Cell Line; Cell Line, Tumor; Epithelial Cells; Female; Guanosine; Humans; Imidazoles; Ions; Mammary Glands, Human; Metabolic Networks and Pathways; Ribonucleosides; Ribose; S-Adenosylmethionine; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Uridine | 2007 |
5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls?
Topics: Aminoimidazole Carboxamide; Antineoplastic Agents; Child; Humans; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Ribonucleosides | 2007 |
Role of AMP-activated protein kinase in autophagy and proteasome function.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cells, Cultured; Down-Regulation; Fibroblasts; Humans; Membrane Proteins; Multienzyme Complexes; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Serine-Threonine Kinases; Ribonucleosides; Vacuoles | 2008 |
Acadesine: AICA riboside, ARA 100, arasine, GP 1 110.
Topics: Aminoimidazole Carboxamide; Animals; Clinical Trials as Topic; Drug Design; Drug Evaluation, Preclinical; Drug Interactions; Humans; Purinergic P1 Receptor Agonists; Ribonucleosides | 2008 |
Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Blastocyst; Blotting, Western; Cell Line; Deoxyglucose; Enzyme Activation; Female; Hypoglycemic Agents; Insulin; Insulin Resistance; Mice; Phenformin; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptor, IGF Type 1; Ribonucleosides; Ribosomal Protein S6 Kinases, 70-kDa; RNA Interference; Signal Transduction | 2008 |
Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Culture Techniques; Cell Line, Tumor; Diabetes Mellitus, Type 2; Disease Models, Animal; Energy Metabolism; Glucose; Hyperglycemia; Immunity; Leptin; Macrophage Activation; Macrophages, Peritoneal; Mice; Pinocytosis; Pyrazoles; Pyrimidines; Ribonucleosides | 2008 |
Is ZMP the toxic metabolite in Lesch-Nyhan disease?
Topics: Aminoimidazole Carboxamide; Cell Line, Tumor; Humans; Hypoxanthine Phosphoribosyltransferase; Inosine Monophosphate; Lesch-Nyhan Syndrome; Models, Biological; Models, Chemical; Models, Theoretical; Oxidative Phosphorylation; Purines; Ribonucleosides; Ribonucleotides | 2008 |
The need for a multi-level biochemical approach to defeat cancer that will also support the host.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Enzyme Activation; Homeostasis; Humans; Models, Theoretical; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Ribonucleosides; Uridine Triphosphate | 2008 |
Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle.
Topics: Adenine Nucleotides; Amino Acids, Branched-Chain; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Enzyme Activation; Injections, Subcutaneous; Insulin; Leucine; Male; Muscle Proteins; Muscle, Skeletal; Rats; Rats, Sprague-Dawley; Ribonucleosides | 2008 |
Kinase activity-independent suppression of p73alpha by AMP-activated kinase alpha (AMPKalpha).
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Antineoplastic Agents; Apoptosis; Cell Proliferation; Chromatin Immunoprecipitation; Cisplatin; Cyclin-Dependent Kinase Inhibitor p21; DNA-Binding Proteins; Gene Library; Glutathione Transferase; HeLa Cells; Humans; Luciferases; Microscopy, Fluorescence; Neoplasms; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Ribonucleosides; RNA, Small Interfering; Transfection; Tumor Cells, Cultured; Tumor Protein p73; Tumor Suppressor Protein p53; Tumor Suppressor Proteins; Two-Hybrid System Techniques | 2009 |
AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts.
Topics: Aminoimidazole Carboxamide; Animals; Cell Differentiation; Cell Line; Embryonic Stem Cells; Fibroblasts; In Vitro Techniques; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Mice; Mice, Inbred Strains; Proto-Oncogene Proteins c-myc; Ribonucleosides; RNA, Messenger; Tretinoin; Up-Regulation | 2009 |
AMP-activated protein kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1/Akt signaling in C2C12 myotubes.
Topics: Acetyl-CoA Carboxylase; Adaptor Proteins, Signal Transducing; Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Differentiation; Cell Line; Dose-Response Relationship, Drug; Eukaryotic Initiation Factors; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation, Enzymologic; Insulin-Like Growth Factor I; Mice; Muscle Fibers, Skeletal; Muscle Proteins; Muscle, Skeletal; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinases; Protein Transport; Proto-Oncogene Proteins c-akt; Ribonucleosides; Signal Transduction; Sirolimus; SKP Cullin F-Box Protein Ligases; TOR Serine-Threonine Kinases; Tripartite Motif Proteins; Ubiquitin-Protein Ligases | 2009 |
Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function.
Topics: Amino Acid Sequence; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Bone Density; Cell Differentiation; Cell Survival; Enzyme Activation; Gene Deletion; Germ-Line Mutation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; Osteoblasts; Osteoclasts; Phenotype; Protein Subunits; Ribonucleosides | 2010 |
AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Enzyme Activation; Enzyme Activators; Extracellular Signal-Regulated MAP Kinases; Glucose Transport Proteins, Facilitative; Hypoglycemic Agents; In Vitro Techniques; Isoenzymes; Male; Metformin; Mice; Mice, Knockout; Muscle Fibers, Skeletal; Physical Conditioning, Animal; Protein Kinase C; Rats; Ribonucleosides; Second Messenger Systems; Signal Transduction | 2010 |
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apoptosis; Autophagy; Cell Line, Tumor; Cell Proliferation; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Mice; Mice, Nude; Protein Kinase C; Ribonucleosides; RNA, Small Interfering; Translocation, Genetic | 2009 |
Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway.
Topics: Adenosine A2 Receptor Antagonists; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Apolipoproteins E; Atherosclerosis; Blood Coagulation; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Fibrinolytic Agents; Humans; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Monocytes; NF-kappa B; Phosphatidylinositol 3-Kinases; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Pyrazoles; Pyrimidines; Receptor, Adenosine A2A; Ribonucleosides; RNA, Messenger; Sepsis; Signal Transduction; Thromboplastin; Transcription Factor AP-1; Triazines; Triazoles; Up-Regulation; Venous Thrombosis | 2010 |
Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy.
Topics: Aminoimidazole Carboxamide; Animals; Atrophy; Autophagy; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Lysosomes; Mice; Mitochondria; Muscles; NF-kappa B; Proteasome Endopeptidase Complex; Ribonucleosides; Ribonucleotides; Transcription Factors; Ubiquitin-Protein Ligases | 2010 |
Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and cumulus-enclosed oocytes in vitro.
Topics: 1-Methyl-3-isobutylxanthine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cattle; Cumulus Cells; Female; Meiosis; Metformin; Oocytes; Phosphorylation; Purines; Ribonucleosides; Roscovitine | 2011 |
AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells.
Topics: Adult; Aged; Aged, 80 and over; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Cell Line, Tumor; Cells, Cultured; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Membrane Proteins; Mice; Middle Aged; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Ribonucleosides; Tumor Suppressor Protein p53; Up-Regulation | 2010 |
Studies on ligand binding to histidine triad nucleotide binding protein 1.
Topics: Aminoimidazole Carboxamide; Animals; Crystallography, X-Ray; Ligands; Magnetic Resonance Spectroscopy; Mice; Nerve Tissue Proteins; Protein Binding; Protein Structure, Tertiary; Ribonucleosides; Spectrometry, Fluorescence | 2010 |
Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK.
Topics: Alcohol Dehydrogenase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Calcium; Caspase 3; Cell Shape; Cells, Cultured; Central Nervous System Depressants; Ethanol; Female; Heart; Insulin-Like Growth Factor I; JNK Mitogen-Activated Protein Kinases; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Myocardium; Myocytes, Cardiac; Organ Size; Proto-Oncogene Proteins c-bcl-2; Ribonucleosides | 2011 |
Enhancement of extracellular purine nucleoside accumulation by Bacillus strains through genetic modifications of genes involved in nucleoside export.
Topics: Aminoimidazole Carboxamide; Bacillus; Bacterial Proteins; Escherichia coli; Female; Genes, Bacterial; Genetic Engineering; Humans; Industrial Microbiology; Inosine; Nucleoside Transport Proteins; Purine Nucleosides; Ribonucleosides; Transformation, Genetic | 2011 |
Potential role of adenosine monophosphate-activated protein kinase in regulation of energy metabolism in dairy goat mammary epithelial cells.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carnitine O-Palmitoyltransferase; Energy Metabolism; Enzyme Activation; Enzyme Activators; Epithelial Cells; Fatty Acid Synthases; Female; Gene Expression; Glucose; Glucose Transporter Type 1; Glycogen Synthase; Goats; Lipid Metabolism; Mammary Glands, Animal; Ribonucleosides; RNA, Messenger; Signal Transduction | 2011 |
Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway.
Topics: Aged; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cells, Cultured; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Genistein; Hep G2 Cells; Hepatocytes; Humans; Male; Middle Aged; Resveratrol; Ribonucleosides; Signal Transduction; Stilbenes | 2011 |
Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Biological Transport; CD36 Antigens; Fatty Acids; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle Contraction; Muscle, Skeletal; Physical Conditioning, Animal; Protein Transport; Rats; Ribonucleosides | 2011 |
Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Liver Neoplasms; Metformin; PPAR alpha; PPAR gamma; Rats; Ribonucleosides; Rosiglitazone; Thiazolidinediones; Transcriptional Activation | 2011 |
Acute therapeutic use of 5-aminoimidazole-4-carboxamide ribonucleoside extends survival interval in response to severe hemorrhagic shock.
Topics: Aminoimidazole Carboxamide; Animals; Rats; Rats, Sprague-Dawley; Ribonucleosides; Shock, Hemorrhagic | 2011 |
Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury.
Topics: Adenosine Triphosphate; Aminoimidazole Carboxamide; Animals; Carnitine; Carnitine O-Palmitoyltransferase; Drug Therapy, Combination; Energy Metabolism; Fatty Acids; Kidney; Male; Rats; Rats, Sprague-Dawley; Recovery of Function; Reperfusion Injury; Ribonucleosides | 2012 |
5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Enzyme Activation; Gene Knockdown Techniques; Humans; Male; Metabolism; Prostatic Neoplasms; Radiation Tolerance; Radiation-Sensitizing Agents; Radiation, Ionizing; Reactive Oxygen Species; Ribonucleosides; Ribonucleotides; RNA, Small Interfering; Time Factors; Tumor Stem Cell Assay | 2011 |
Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Analysis of Variance; Cells, Cultured; Citric Acid Cycle; Enzyme Activation; Glycolysis; Human Umbilical Vein Endothelial Cells; Humans; Metabolic Networks and Pathways; Metabolome; Metabolomics; Nuclear Magnetic Resonance, Biomolecular; Phospholipids; Ribonucleosides | 2012 |
5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation.
Topics: Adenylate Kinase; Aminoimidazole Carboxamide; Animals; Antigens, Differentiation; Cell Differentiation; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Embryoid Bodies; Embryonic Stem Cells; Endothelial Cells; Enzyme Activation; Enzyme Activators; Erythroid Cells; G1 Phase Cell Cycle Checkpoints; Gene Expression Regulation; Homeodomain Proteins; Humans; Lewis X Antigen; Mice; Nanog Homeobox Protein; Ribonucleosides; Tumor Suppressor Protein p53 | 2012 |
Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antibiotics, Antineoplastic; Cell Death; Cells, Cultured; DNA Damage; Dose-Response Relationship, Drug; Doxorubicin; Embryo, Mammalian; Enzyme Activation; Enzyme Activators; Fibroblasts; Gene Deletion; Mice; Mice, Knockout; Myocytes, Cardiac; Ribonucleosides; Sirtuin 1; Tumor Suppressor Protein p53 | 2012 |
Suppression of adipose lipolysis by long-chain fatty acid analogs.
Topics: 3T3-L1 Cells; Adenylyl Cyclases; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Fatty Acids; Isoproterenol; Lipolysis; Male; MAP Kinase Kinase Kinases; Mice; Proto-Oncogene Proteins c-raf; Rats; Rats, Wistar; Ribonucleosides; Signal Transduction; Unfolded Protein Response | 2012 |
Impact of glucagon-like peptide-1 (7-36) amide, isosteviol and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside on leucine-mediated α-cell dysfunction.
Topics: Aminoimidazole Carboxamide; Animals; Cells, Cultured; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Glucagon; Glucagon-Like Peptide 1; Glucagon-Secreting Cells; Leucine; Mice; Mice, Transgenic; Peptide Fragments; Protein Precursors; Ribonucleosides | 2012 |
5-Aminoimidazole-4-carboxamide ribonucleoside stabilizes low density lipoprotein receptor mRNA in hepatocytes via ERK-dependent HuR binding to an AU-rich element.
Topics: Aminoimidazole Carboxamide; AU Rich Elements; Cells, Cultured; ELAV Proteins; Hepatocytes; Humans; MAP Kinase Signaling System; Protein Binding; Receptors, LDL; Ribonucleosides; RNA, Messenger | 2013 |
AMP-activated protein kinase inhibits TGF-β-, angiotensin II-, aldosterone-, high glucose-, and albumin-induced epithelial-mesenchymal transition.
Topics: Albumins; Aldosterone; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Angiotensin II; Cell Line; Epithelial-Mesenchymal Transition; Glucose; Heme Oxygenase-1; Humans; Metformin; NADPH Oxidase 4; NADPH Oxidases; Nephrosclerosis; Pyrazoles; Pyrimidines; Reactive Oxygen Species; Ribonucleosides; Thioredoxins; Transforming Growth Factor beta | 2013 |
A HPLC method for simultaneous determination of 5-aminoimidazole-4-carboxamide riboside and its active metabolite 5-aminoimidazole-4-carboxamide ribotide in tumor-bearing nude mice plasma and its application to pharmacokinetics study.
Topics: Aminoimidazole Carboxamide; Animals; Chromatography, High Pressure Liquid; Drug Stability; Female; Humans; Linear Models; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Reproducibility of Results; Ribonucleosides; Ribonucleotides; Sensitivity and Specificity; Solid Phase Extraction; Temperature; Transplantation, Heterologous | 2013 |
VASP increases hepatic fatty acid oxidation by activating AMPK in mice.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blotting, Western; Cell Adhesion Molecules; Fatty Acids; Liver; Mice; Mice, Mutant Strains; Microfilament Proteins; Oxidation-Reduction; Phosphoproteins; Phosphorylation; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleosides | 2013 |
Caudal fourth ventricular administration of the AMPK activator 5-aminoimidazole-4-carboxamide-riboside regulates glucose and counterregulatory hormone profiles, dorsal vagal complex metabolosensory neuron function, and hypothalamic Fos expression.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aortic Bodies; Blood Glucose; Dose-Response Relationship, Drug; Estradiol; Female; Fourth Ventricle; Hypothalamus; Laser Capture Microdissection; Nerve Tissue Proteins; Oncogene Proteins v-fos; Rats; Rats, Sprague-Dawley; Receptors, Adenosine A2; Ribonucleosides; Sensory Receptor Cells; Time Factors | 2013 |
Synthesis of new acadesine (AICA-riboside) analogues having acyclic D-ribityl or 4-hydroxybutyl chains in place of the ribose.
Topics: Aminoimidazole Carboxamide; Antiviral Agents; Humans; Nucleotides; Ribonucleosides; Ribose; Structure-Activity Relationship; Viruses | 2013 |
Connection between cardiac vascular permeability, myocardial edema, and inflammation during sepsis: role of the α1AMP-activated protein kinase isoform.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Capillary Permeability; Cells, Cultured; Coloring Agents; Cytokines; Echocardiography; Edema; Endothelial Cells; Endotoxemia; Evans Blue; Gene Silencing; Heart Diseases; Heart Ventricles; Humans; Inflammation; Lipopolysaccharides; Lung; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Ribonucleosides; Tight Junctions | 2013 |
Loss of the anorexic response to systemic 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside administration despite reducing hypothalamic AMP-activated protein kinase phosphorylation in insulin-deficient rats.
Topics: Acetyl-CoA Carboxylase; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Appetite Depressants; Body Composition; Body Weight; Diabetes Mellitus; Drinking; Energy Metabolism; Hypothalamus; Insulin; Leptin; Male; Muscle, Skeletal; Phosphorylation; Rats; Rats, Wistar; Ribonucleosides; Signal Transduction; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2013 |
AMPK agonist AICAR improves cognition and motor coordination in young and aged mice.
Topics: Aging; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Central Nervous System Agents; Dose-Response Relationship, Drug; Female; Hippocampus; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Muscle, Skeletal; Psychomotor Performance; Ribonucleosides; Space Perception; Time Factors | 2014 |
Synergistic anti-tumor activity of acadesine (AICAR) in combination with the anti-CD20 monoclonal antibody rituximab in in vivo and in vitro models of mantle cell lymphoma.
Topics: Aminoimidazole Carboxamide; Animals; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cohort Studies; Disease Models, Animal; Drug Synergism; Female; Humans; Lymphoma, Mantle-Cell; Mice; Mice, SCID; Random Allocation; Ribonucleosides; Rituximab; Xenograft Model Antitumor Assays | 2014 |
DNA aneuploidy-specific therapy for head and neck squamous cell carcinoma.
Topics: Aged; Aged, 80 and over; Aminoimidazole Carboxamide; Aneuploidy; Benzoquinones; Carcinoma, Squamous Cell; Case-Control Studies; DNA Mutational Analysis; Female; Genetic Therapy; Head and Neck Neoplasms; Humans; Keratinocytes; Lactams, Macrocyclic; Male; Middle Aged; Molecular Targeted Therapy; Mutation, Missense; Ribonucleosides; Sensitivity and Specificity; Squamous Cell Carcinoma of Head and Neck; Treatment Outcome; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2015 |
ERK1/2 antagonize AMPK-dependent regulation of FcεRI-mediated mast cell activation and anaphylaxis.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Anaphylaxis; Animals; Butadienes; Cell Degranulation; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Hypersensitivity; Mast Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Nitriles; Receptors, IgG; Ribonucleosides; Signal Transduction | 2014 |
AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells.
Topics: Active Transport, Cell Nucleus; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Biphenyl Compounds; Carcinoma, Hepatocellular; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gene Silencing; Humans; Intracellular Signaling Peptides and Proteins; Kelch-Like ECH-Associated Protein 1; Liver Neoplasms; NF-E2-Related Factor 2; Phosphorylation; Pyrones; Ribonucleosides; Thiophenes | 2014 |
Short-chain fatty acids enhance adipocyte differentiation in the stromal vascular fraction of porcine adipose tissue.
Topics: Acetylation; Adipocytes; Adipose Tissue; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Butyrates; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Chromatin Immunoprecipitation; Fatty Acids, Volatile; Female; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Male; PPAR gamma; Promoter Regions, Genetic; Propionates; Ribonucleosides; RNA, Messenger; Swine | 2014 |
Utrophin A is essential in mediating the functional adaptations of mdx mouse muscle following chronic AMPK activation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Dystroglycans; Female; Genotyping Techniques; Hand Strength; Male; Mice; Mice, Inbred mdx; Mice, Knockout; Muscular Dystrophy, Duchenne; Myofibrils; Phenotype; Ribonucleosides; Utrophin | 2015 |
Estradiol regulates effects of hindbrain activator 5-aminoimidazole-4-carboxamide-riboside administration on hypothalamic adenosine 5'-monophosphate-activated protein kinase activity and metabolic neurotransmitter mRNA and protein expression.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Analysis of Variance; Animals; Cortisone; Dose-Response Relationship, Drug; Eating; Estradiol; Female; Gene Expression Regulation; Glucose; Hypothalamus; Neurotransmitter Agents; Ovariectomy; Pro-Opiomelanocortin; Rats; Rats, Sprague-Dawley; Ribonucleosides; Ribonucleotides; RNA, Messenger | 2015 |
5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside alleviated carbon tetrachloride-induced acute hepatitis in mice.
Topics: Alanine Transaminase; Aminoimidazole Carboxamide; Animals; Anti-Inflammatory Agents; Aspartate Aminotransferases; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Hepatitis; Interleukin-6; Liver; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Mice, Inbred BALB C; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Ribonucleosides; RNA, Messenger; Tumor Necrosis Factor-alpha | 2015 |
Pharmacological and Morphological Evidence of AMPK-Mediated Energy Sensing in the Lower Brain Stem Ependymocytes to Control Reproduction in Female Rodents.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Brain; Brain Stem; Female; Immunohistochemistry; Mice; Mice, Transgenic; Rats; Reproduction; Ribonucleosides | 2015 |
Activation of AMP-activated protein kinase prevents TGF-β1-induced epithelial-mesenchymal transition and myofibroblast activation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cadherins; Epithelial-Mesenchymal Transition; Fibronectins; Humans; Kidney Tubules, Proximal; Mice; Mice, Knockout; Myofibroblasts; Phosphorylation; Ribonucleosides; Transforming Growth Factor beta1 | 2015 |
Bcl-2high mantle cell lymphoma cells are sensitized to acadesine with ABT-199.
Topics: Actins; Aminoimidazole Carboxamide; Animals; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Cell Adhesion Molecules; Cell Line, Tumor; Cell Movement; Chemokine CXCL12; Chemotaxis; Down-Regulation; Drug Resistance, Neoplasm; Drug Synergism; Female; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Lymphoma, Mantle-Cell; Mice; Mice, SCID; Microfilament Proteins; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Transplantation; Phosphoproteins; Proto-Oncogene Proteins c-bcl-2; Ribonucleosides; Sulfonamides | 2015 |
5-Aminoimidazole-4-carboxyamide-1-β-D-ribofranoside stimulates the rat enhancer of split- and hairy-related protein-2 gene via atypical protein kinase C lambda.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Basic Helix-Loop-Helix Transcription Factors; Calcium; Cycloheximide; Dactinomycin; Enzyme Activation; Gene Expression; HEK293 Cells; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Isoenzymes; Liver; Phosphatidylinositol 3-Kinases; Phosphoenolpyruvate Carboxykinase (GTP); Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Protein Synthesis Inhibitors; Pyrazoles; Pyrimidines; Rats; Ribonucleosides; RNA Polymerase II; RNA, Messenger; Signal Transduction; Transcription, Genetic | 2016 |
AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease.
Topics: Adenosine Monophosphate; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain; Caenorhabditis elegans; Cell Death; Corpus Striatum; Disease Models, Animal; Humans; Huntington Disease; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neostriatum; Neurons; Phosphorylation; Ribonucleosides | 2016 |
[Acadesine Inhibits the Proliferation of K562 Cells and Enhances their Sensitivity to Imatinib].
Topics: Aminoimidazole Carboxamide; Apoptosis; Caspase 3; Cell Cycle Checkpoints; Cell Proliferation; Cyclin D1; Cyclin E; Humans; Imatinib Mesylate; K562 Cells; Oncogene Proteins; Ribonucleosides | 2016 |
AMPK-dependent and independent effects of AICAR and compound C on T-cell responses.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Calcium Signaling; Cell Death; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Genotype; Immunologic Factors; Lymphocyte Activation; Mice, Knockout; Phenotype; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Ribonucleosides; T-Lymphocytes; TOR Serine-Threonine Kinases | 2016 |
The imidazoline compound RX871024 promotes insulinoma cell death independent of AMP-activated protein kinase inhibition.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Cell Death; Cell Line; Imidazoles; Indoles; Insulin-Secreting Cells; Insulinoma; Mice, Obese; Phosphorylation; Ribonucleosides | 2016 |
Neuroprotective effect of activated 5'-adenosine monophosphate-activated protein kinase on cone system function during retinal inflammation.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Disease Models, Animal; Glial Fibrillary Acidic Protein; Lipopolysaccharides; Male; Mice, Inbred C57BL; Mitochondria; Neuroprotective Agents; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Random Allocation; Retinal Cone Photoreceptor Cells; Retinitis; Ribonucleosides; RNA, Messenger; Tumor Necrosis Factor-alpha | 2016 |
Doping control study of AICAR in post-race urine and plasma samples from horses.
Topics: Aminoimidazole Carboxamide; Animals; Australia; Chromatography, Liquid; Doping in Sports; Horses; Humans; Ribonucleosides; Ribonucleotides; Tandem Mass Spectrometry; Urinalysis | 2017 |
AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Apoptosis; Cell Survival; Hep G2 Cells; Humans; Isoniazid; Mitochondria; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Ribonucleosides; Sirtuin 1 | 2017 |
The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax.
Topics: Adenine; Aminoimidazole Carboxamide; Apoptosis; Bridged Bicyclo Compounds, Heterocyclic; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; Humans; Hydrocarbons, Fluorinated; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Piperidines; Prohibitins; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Pyrimidines; Repressor Proteins; Ribonucleosides; Sulfonamides; Thiazolidines; Tumor Cells, Cultured; Up-Regulation | 2017 |
AICAR suppresses TNF-α-induced complement factor B in RPE cells.
Topics: Aminoimidazole Carboxamide; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; Complement Activation; Complement Factor B; Dipyridamole; Humans; Macular Degeneration; Phosphotransferases (Phosphate Group Acceptor); Retinal Pigment Epithelium; Ribonucleosides; Tubercidin; Tumor Necrosis Factor-alpha | 2017 |
AICAR Prevents Acute Olanzapine-Induced Disturbances in Glucose Homeostasis.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Blood Glucose; Glucose; Homeostasis; Hyperglycemia; Insulin; Liver; Male; Mice; Mice, Inbred C57BL; Olanzapine; Pyruvic Acid; Ribonucleosides; Signal Transduction | 2018 |
AICAR Antiproliferative Properties Involve the AMPK-Independent Activation of the Tumor Suppressors LATS 1 and 2.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antineoplastic Agents; Cell Proliferation; Cells, Cultured; Enzyme Activation; Epithelial Cells; Fibroblasts; Humans; Mice; Mice, Knockout; Phosphoproteins; Protein Serine-Threonine Kinases; Ribonucleosides; Signal Transduction; Transcription Factors; Transcription, Genetic; Transcriptome; Tumor Suppressor Proteins; Up-Regulation | 2018 |
The Chinese medicine Chai Hu Li Zhong Tang protects against non-alcoholic fatty liver disease by activating AMPKα.
Topics: Acetyl-CoA Carboxylase; Alanine Transaminase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Aspartate Aminotransferases; Bupleurum; Cholesterol, HDL; Cholesterol, LDL; Drugs, Chinese Herbal; Gene Expression Regulation; Hep G2 Cells; Humans; Medicine, Chinese Traditional; Non-alcoholic Fatty Liver Disease; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Ribonucleosides; Sterol Regulatory Element Binding Protein 2; Triglycerides | 2018 |
The ribonucleoside AICAr induces differentiation of myeloid leukemia by activating the ATR/Chk1 via pyrimidine depletion.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Cell Differentiation; Cell Line, Tumor; Checkpoint Kinase 1; Dihydroorotate Dehydrogenase; Humans; Leukemia, Promyelocytic, Acute; Oxidoreductases Acting on CH-CH Group Donors; Pyrimidines; Ribonucleosides; S Phase Cell Cycle Checkpoints | 2019 |
Metformin prevents the pathological browning of subcutaneous white adipose tissue.
Topics: Acetyl-CoA Carboxylase; Adipocytes, Beige; Adipose Tissue, White; Adult; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Burns; Disease Models, Animal; Humans; Lipolysis; Metformin; Mice; Mice, Inbred C57BL; Mitochondria; Okadaic Acid; Oxidative Phosphorylation; Protein Phosphatase 2; Ribonucleosides; Sterol Esterase; Subcutaneous Fat | 2019 |
Expression and purification of the 5'-nucleotidase YitU from Bacillus species: its enzymatic properties and possible applications in biotechnology.
Topics: 5'-Nucleotidase; Aminoimidazole Carboxamide; Bacillus; Bacillus amyloliquefaciens; Bacillus subtilis; Bacterial Proteins; Cloning, Molecular; Escherichia coli; Gene Expression; Kinetics; Purine Nucleotides; Recombinant Proteins; Riboflavin; Ribonucleosides; Substrate Specificity | 2020 |
5-aminoimidazole-4-carboxamide ribonucleoside induces differentiation in a subset of primary acute myeloid leukemia blasts.
Topics: Aminoimidazole Carboxamide; Biomarkers, Tumor; Blast Crisis; Bone Marrow; Case-Control Studies; Cell Differentiation; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Myeloid, Acute; Ribonucleosides; RNA-Seq; Tumor Cells, Cultured | 2020 |
Brain-Derived Neurotrophic Factor Improves Impaired Fatty Acid Oxidation Via the Activation of Adenosine Monophosphate-Activated Protein Kinase-ɑ - Proliferator-Activated Receptor-r Coactivator-1ɑ Signaling in Skeletal Muscle of Mice With Heart Failure.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Brain-Derived Neurotrophic Factor; Exercise Tolerance; Fatty Acids; Heart Failure; Humans; Male; Mice; Mice, Knockout; Microscopy, Electron, Transmission; Mitochondria; Muscle, Skeletal; Myocardial Infarction; Oxidation-Reduction; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Recombinant Proteins; Ribonucleosides | 2021 |
Acadesine suppresses TNF-α induced complement component 3 (C3), in retinal pigment epithelial (RPE) cells.
Topics: Adenosine; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Line; Cells, Cultured; Complement Activation; Complement C3; Humans; Macular Degeneration; Phosphorylation; Retinal Pigment Epithelium; Retinal Pigments; Ribonucleosides; Ribonucleotides; Tumor Necrosis Factor-alpha | 2020 |
Medium & long-chain acylcarnitine's relation to lipid metabolism as potential predictors for diabetic cardiomyopathy: a metabolomic study.
Topics: Adult; Aminoimidazole Carboxamide; Animals; Biomarkers; Carnitine; Cell Line; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Female; Humans; Lipid Metabolism; Male; Mass Spectrometry; Middle Aged; Myoblasts, Cardiac; Myristic Acids; Rats; Retrospective Studies; Ribonucleosides; Risk Factors | 2021 |
Acadesine alleviates acute pancreatitis-related lung injury by mediating the barrier protective function of pulmonary microvascular endothelial cells.
Topics: Acute Disease; Acute Lung Injury; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Antioxidants; Endothelial Cells; Humans; Inflammation; Mice; NF-E2-Related Factor 2; Pancreatitis; Ribonucleosides; Signal Transduction | 2022 |