aminoglutethimide and spironolactone

aminoglutethimide has been researched along with spironolactone in 24 studies

Research

Studies (24)

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (58.33)	18.7374
1990's	3 (12.50)	18.2507
2000's	4 (16.67)	29.6817
2010's	3 (12.50)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Liddle, GW	2
Aguilera, G; Catt, KJ	1
Koelmeyer, TD; Woods, WP	1
Brun, HP; Caillaud, JM; Cordier, A; Leonard, JF; Melcion, C; Moronvalle, V	1
Fair, WR; Sogani, PC	1
Gaunt, R; Gisoldi, E; Herkner, J; Howie, N; Renzi, AA	1
Siegenthaler, W; Werning, C	2
Gregorová, I; Horký, K; Jiránková, J; Küchel, O; Matys, Z	1
Harinck, HI; Moolenaar, AJ; van Brummelen, P; Van Seters, AP	1
Kinouchi, T; Shimizu, N	1
Elias, AN; Gwinup, G	1
Bartter, FC; Gill, JR	1
Abe, K; Arakawa, K; Asano, T; Kawasaki, T; Okumura, M; Sasaki, H	1
Borkowski, J; Gentsch, C; Mondadori, C	1
Bare, RL; Torti, FM	1
Ceballos, NR; Pozzi, AG	1
Borowicz, KK; Czuczwar, SJ	2

Reviews

4 review(s) available for aminoglutethimide and spironolactone

Article	Year
Treatment of advanced prostatic cancer. The Urologic clinics of North America, 1987, Volume: 14, Issue:2 Topics: Adrenalectomy; Aminoglutethimide; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyproterone; Cyproterone Acetate; Estrogens; Flutamide; Glucocorticoids; Humans; Ketoconazole; Male; Megestrol; Megestrol Acetate; Orchiectomy; Pituitary Hormone-Releasing Hormones; Prostatic Neoplasms; Spironolactone; Time Factors	1987
[Pharmacological mechanism of modern diuretics. Aldosterone antagonists]. Nihon rinsho. Japanese journal of clinical medicine, 1984, Volume: 42, Issue:9 Topics: Aldosterone; Aminoglutethimide; Angiotensin-Converting Enzyme Inhibitors; Diuretics; Humans; Kidney Tubules, Distal; Metyrapone; Mineralocorticoid Receptor Antagonists; Receptors, Glucocorticoid; Receptors, Mineralocorticoid; Spironolactone	1984
Effects of some clinically encountered drugs on steroid synthesis and degradation. Metabolism: clinical and experimental, 1980, Volume: 29, Issue:6 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Drug Interactions; Ethanol; Fetus; Gonadal Steroid Hormones; Gonadotropins, Pituitary; Humans; Hydrocortisone; Hydroxycholecalciferols; Liver; Metyrapone; Mitotane; Phenobarbital; Phenytoin; Rifampin; Spironolactone; Steroids	1980
Endocrine therapy of prostate cancer. Cancer treatment and research, 1998, Volume: 94 Topics: 5-alpha Reductase Inhibitors; Adenocarcinoma; Aminoglutethimide; Androgen Antagonists; Antineoplastic Agents, Hormonal; Chemotherapy, Adjuvant; Clinical Trials as Topic; Combined Modality Therapy; Drug Therapy, Combination; Enzyme Inhibitors; Estrogens; Gonadotropin-Releasing Hormone; Humans; Ketoconazole; Male; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Orchiectomy; Prognosis; Prostatic Neoplasms; Receptors, LHRH; Spironolactone; Survival Analysis; Testosterone	1998

Trials

1 trial(s) available for aminoglutethimide and spironolactone

Article

Year

Treatment of advanced prostatic cancer.

The Urologic clinics of North America, 1987, Volume: 14, Issue:2

Topics: Adrenalectomy; Aminoglutethimide; Androgen Antagonists; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Combined Modality Therapy; Cyproterone; Cyproterone Acetate; Estrogens; Flutamide; Glucocorticoids; Humans; Ketoconazole; Male; Megestrol; Megestrol Acetate; Orchiectomy; Pituitary Hormone-Releasing Hormones; Prostatic Neoplasms; Spironolactone; Time Factors

1987

Other Studies

20 other study(ies) available for aminoglutethimide and spironolactone

Article	Year
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
The Distinguished Lecture. Is hypertension essential? Transactions of the Association of American Physicians, 1975, Volume: 88 Topics: Aldosterone; Aminoglutethimide; Angiotensin II; Animals; Dehydroepiandrosterone; Humans; Hypertension; Hypertension, Renal; Mineralocorticoids; Natriuresis; Norepinephrine; Patient Compliance; Phenoxybenzamine; Renal Artery Obstruction; Renin; Saralasin; Spironolactone	1975
Loci of action of regulators of aldosterone biosynthesis in isolated glomerulosa cells. Endocrinology, 1979, Volume: 104, Issue:4 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aldosterone; Aminoglutethimide; Angiotensin II; Animals; Corticosterone; Desoxycorticosterone; Dogs; In Vitro Techniques; Potassium; Progesterone; Rats; Spironolactone	1979
Carcinoma of the lung presenting as Cushing's syndrome. The New Zealand medical journal, 1977, Jan-12, Volume: 85, Issue:579 Topics: Aminoglutethimide; Carcinoma, Bronchogenic; Cortisone; Cushing Syndrome; Cyclophosphamide; Diagnosis, Differential; Female; Humans; Lung Neoplasms; Metyrapone; Middle Aged; Spironolactone	1977
Pig Leydig cell culture: a useful in vitro test for evaluating the testicular toxicity of compounds. Toxicology and applied pharmacology, 1991, Volume: 108, Issue:2 Topics: Aminoglutethimide; Animals; Cell Survival; Cells, Cultured; Chlorpromazine; Chorionic Gonadotropin; Cyclic AMP; Cycloheximide; Ketoconazole; Kinetics; Leydig Cells; Male; Progesterone; Spironolactone; Steroids; Swine; Testis; Testosterone; Time Factors; Toxicology	1991
Sodium retention after adrenal enucleation: drug and salt appetite studies. Endocrinology, 1968, Volume: 83, Issue:5 Topics: Adrenal Glands; Adrenal Medulla; Adrenalectomy; Aminoglutethimide; Animals; Appetite; Body Weight; Depression, Chemical; Diuretics; Drinking; Heparinoids; Hydrochlorothiazide; Male; Methandrostenolone; Metyrapone; Mineralocorticoid Receptor Antagonists; Natriuresis; Potassium; Rats; Regeneration; Sodium; Sodium Chloride; Spironolactone; Water-Electrolyte Balance	1968
[Therapy of secondary hyperaldosteronism]. Minerva medica, 1973, Mar-14, Volume: 64, Issue:14 Topics: Aminoglutethimide; Butanones; Heparin; Humans; Hyperaldosteronism; Metyrapone; Mineralocorticoid Receptor Antagonists; Spironolactone; Triamterene; Triparanol	1973
[Treatment of secondary hyperaldosteronism]. Deutsche medizinische Wochenschrift (1946), 1969, Oct-03, Volume: 94, Issue:40 Topics: Adrenalectomy; Aldosterone; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Diuretics; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Pyridones; Spironolactone; Triamterene	1969
Management of aldosteronism. American journal of clinical pathology, 1970, Volume: 54, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Aminoglutethimide; Humans; Hyperaldosteronism; Mineralocorticoid Receptor Antagonists; Spironolactone	1970
[Inhibitions of steroid biosynthesis in the adrenal gland by aminogluthetimide (Elipten CIBA) and its practical significance]. Vnitrni lekarstvi, 1969, Volume: 15, Issue:5 Topics: 17-Ketosteroids; Adrenal Glands; Aminoglutethimide; Aniline Compounds; Anticonvulsants; Cushing Syndrome; Humans; Hyperaldosteronism; Potassium; Pyridones; Sodium; Spironolactone; Steroids	1969
Apparent mineralocorticoid excess and deficient 11 beta-oxidation of cortisol in a young female. Clinical endocrinology, 1984, Volume: 21, Issue:5 Topics: Adrenocorticotropic Hormone; Adult; Alkalosis; Amiloride; Aminoglutethimide; Dexamethasone; Drug Therapy, Combination; Female; Humans; Hydrocortisone; Hypertension; Hypokalemia; Mineralocorticoids; Oxidation-Reduction; Spironolactone; Syndrome	1984
Overproduction of sodium-retaining steroids by the zona glomerulosa is adrenocorticotropin-dependent and mediates hypertension in dexamethasone-suppressible aldosteronism. The Journal of clinical endocrinology and metabolism, 1981, Volume: 53, Issue:2 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Adult; Aldosterone; Aminoglutethimide; Child, Preschool; Dexamethasone; Female; Humans; Hyperaldosteronism; Hypertension; Kinetics; Pregnancy; Renin; Spironolactone	1981
Bartter's syndrome: effect of indomethacin on prostaglandins, urinary kallikrein, renin-angiotensin-aldosterone system, and the response to angiotensin II antagonist. Endocrinologia japonica, 1980, Volume: 27, Issue:4 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adult; Aldosterone; Aminoglutethimide; Angiotensin II; Aspirin; Bartter Syndrome; Blood Pressure; Diet, Sodium-Restricted; Female; Humans; Hyperaldosteronism; Indomethacin; Kallikreins; Male; Middle Aged; Prostaglandins E; Renin; Spironolactone	1980
The memory-facilitating effects of the competitive NMDA-receptor antagonist CGP 37849 are steroid-sensitive, whereas its memory-impairing effects are not. Psychopharmacology, 1996, Volume: 124, Issue:4 Topics: 2-Amino-5-phosphonovalerate; Aldosterone; Aminoglutethimide; Animals; Corticosterone; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Male; Memory; Mice; Mineralocorticoid Receptor Antagonists; Spironolactone	1996
Human chorionic gonadotropin-induced spermiation in Bufo arenarum is not mediated by steroid biosynthesis. General and comparative endocrinology, 2000, Volume: 119, Issue:2 Topics: 3-Hydroxysteroid Dehydrogenases; Aminoglutethimide; Androgens; Animals; Bufo arenarum; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Cyanoketone; Enzyme Inhibitors; Male; Progesterone; Spermatogenesis; Spironolactone; Steroid 17-alpha-Hydroxylase; Steroids; Testis; Testosterone	2000
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. Journal of neural transmission (Vienna, Austria : 1996), 2005, Volume: 112, Issue:7 Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models, Animal; Drug Interactions; Epilepsy; Female; Kindling, Neurologic; Male; Mineralocorticoid Receptor Antagonists; Phenobarbital; Rats; Rats, Wistar; Seizures; Spironolactone; Valproic Acid	2005
Influence of aminoglutethimide and spironolactone on the efficacy of carbamazepine and diphenylhydantoin against amygdala-kindled seizures in rats. European journal of pharmacology, 2005, Jun-15, Volume: 516, Issue:3 Topics: Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Therapy, Combination; Female; Hydrocortisone; Kindling, Neurologic; Male; Motor Activity; Phenytoin; Rats; Rats, Wistar; Rotarod Performance Test; Seizures; Spironolactone	2005