aminoglutethimide and pregnenolone

aminoglutethimide has been researched along with pregnenolone in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	64 (80.00)	18.7374
1990's	14 (17.50)	18.2507
2000's	1 (1.25)	29.6817
2010's	0 (0.00)	24.3611
2020's	1 (1.25)	2.80

Authors

Authors	Studies
Simpson, ER; Williams-Smith, DL	1
Kitay, JI; Malendowicz, L	1
Jefcoate, CR	1
Brewer, HB; Gwynne, JT; Mahaffee, D; Ney, RL	1
Hall, PF; Mrotek, JJ	1
Hall, PF; Nakamura, M; Watanuki, M	1
Island, DP; Lacroix, A; Liddle, GW; McKenna, TJ; Miller, RB; Nicholson, WE	1
George, FW; Milewich, L; Simpson, ER; Wilson, JD	1
Crivello, JF; Jefcoate, CR	1
Lanthier, A; Patwardhan, VV	1
Arthur, JR; Boyd, GS; Mason, JI	1
Island, DP; Liddle, GW; McKenna, TJ; Nicholson, WE	1
Graves, PE; Salhanick, HA; Uzgiris, VI	1
Salomon, DS; Sherman, MI	1
Graves, P; McIntosh, EN; Salhanick, HA; Uzgiris, VI	1
First, NL; Torres, CA	1
Choi, MS; Cooke, BA	1
Lambeth, JD; Stevens, VL; Xu, T	1
Hertelendy, F; Iczkowski, KA	1
Cooke, GM	1
Jefcoate, CR; McNamara, BC	2
Alvarez, JG; Fischer, RT; Rennert, H; Strauss, JF; Trzaskos, JM	1
Baulieu, EE; Hu, ZY; Jung-Testas, I; Robel, P	1
Alberts, D; Doris, PA; Durham, D; Kilgore, MW; Stocco, DM	1
Dhariwal, MS; Jefcoate, CR; McNamara, BC; Privalle, CT	1
Ghosh, DK; Holt, JA; Menon, KM; Schreiber, JR; Wittmaack, FM	1
Lin, YW; Petrino, TR; Wallace, RA	1
Belanger, A; Caron, S; Labrie, F; Lacoste, D; St-Arnaud, R	1
Barrie, SE; Jarman, M; Leung, CS; Rowlands, MG	1
Ghersi-Egea, JF; Minn, A; Siest, G; Walther, B	1
Glover, M; Lambeth, JD; Xu, XX	1
Ikeda, M; Katagiri, M; Koshida, H; Miyamori, I; Nagai, K; Suhara, K; Takeda, R	1
Cheng, B; Hsu, DK; Kimura, T	1
Holt, JA; Schreiber, JR	1
Colby, HD; Eacho, PI	1
Gláz, E; Kelemen, J; Szabó, D	1
Dexter, RN; Fishman, LM; Liddle, GW; Ney, RL	1
Brough, AJ; Cash, R; Cohen, MN; Satoh, PS	1
Camacho, AM; Hagen, AA; Trouy, RL; Wilroy, RS	1
Johnston, GG; Krisle, JR; Troop, RC	1
Kowal, J	1
Dexter, RN; Fishman, LM; Ney, RL	1
Temple, R; Wolff, J	1
Mahaffee, D; Ney, RL; Reitz, RC	1
Haksar, A; Lin, M; Peron, FG	1
Mahaffee, D; Ney, RL; Reitz, R	1
Boyd, GS; Brownie, AC; Jefcoate, CR; Orme-Johnson, WH; Simpson, ER	1
Gower, DB	1
Cohen, MP	1
Cohen, MP; Moriwaki, K	1
Carballeira, A; Durnhofer, F; Fishman, LM	1
Marek, J; Motlík, K; Stárka, L	1
Jeffries, CD; Wilkins, J	1
Harding, BW; Wilson, LD	1
Gower, DB; Lessof, MH; Lyne, C	1
Chytil, F; Glasser, SR; Northcutt, RC; Strott, CA	1
Counsell, RE; el-Masry, S; Lu, MC; Weinhold, PA	1
Marek, J; Motlík, K; Thoenes, W	1
Goldman, AS	1
Corcelle-Cerf, F; Kolanowski, J; Lambert, F; Lammerant, J	1
Ascoli, M; Puett, D; Segaloff, DL	1
Aquilano, DR; Dufau, ML; Hattori, MA	1
Ascoli, M; Freeman, DA; Sheets, JJ; Vickery, LE	1
Grodzicki, RL; Hourihan, J; Salhanick, HA; Whipple, CA	1
Lemon, M; Mauléon, P	1
Harding, BW; Tsao, K; von Dippe, PJ	1
Sheets, JJ; Vickery, LE	1
Chavis, TR; Dimino, MJ; Downing, JR	1
Check, WA	1
Darbeida, H; Durand, P; Picard-Hagen, N	1
Cascio, C; Guarneri, P; Guarneri, R; Papadopoulos, V; Pavasant, P; Piccoli, F	1
De Villiers, EP; Swart, AC; Swart, P; Todres, PC; van der Merwe, KJ	1
Jefcoate, CR; McNamara, BC; Yamazaki, T	1
Cok, SJ; Hay, RV; Holt, JA	1
Abrahamsen, GC; Carr, KD; Kandawire, MJ	1
Cascio, C; Lieberman, S; Lin, YY; Papadopoulos, V; Prasad, VV	1
Cuéllar, A; Díaz-Sánchez, V; Morales, A; Ramírez, J; Vilchis, F	1
Glaser, M; Zhu, TS	1
Cheung, G; Lin, YC; Papadopoulos, V; Porter, E	1

Reviews

1 review(s) available for aminoglutethimide and pregnenolone

Article	Year
Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications. Journal of steroid biochemistry, 1974, Volume: 5, Issue:5 Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aminoglutethimide; Androgens; Androstenedione; Animals; Cholesterol; Dexamethasone; Estrogens; Estrone; Glutethimide; Hormones; Humans; Hydrocortisone; Methane; Metyrapone; Microscopy, Electron; Pharmacology; Phenols; Pregnenolone; Pyridines; Steroid Hydroxylases; Steroids; Time Factors	1974

Article

Year

Modifiers of steroid-hormone metabolism: a review of their chemistry, biochemistry and clinical applications.

Journal of steroid biochemistry, 1974, Volume: 5, Issue:5

Topics: Adrenal Cortex; Adrenocorticotropic Hormone; Aminoglutethimide; Androgens; Androstenedione; Animals; Cholesterol; Dexamethasone; Estrogens; Estrone; Glutethimide; Hormones; Humans; Hydrocortisone; Methane; Metyrapone; Microscopy, Electron; Pharmacology; Phenols; Pregnenolone; Pyridines; Steroid Hydroxylases; Steroids; Time Factors

1974

Trials

1 trial(s) available for aminoglutethimide and pregnenolone

Article	Year
Aminoglutethimide (Elipten-Ciba) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial. The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:9 Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aminoglutethimide; Animals; Anticonvulsants; Breast Neoplasms; Child; Cholesterol; Clinical Trials as Topic; Cushing Syndrome; Enzyme Therapy; Enzymes; Epilepsy, Absence; Female; Humans; Lyases; Male; Middle Aged; Neoplasm Metastasis; Pregnenolone; Rats	1967

Article

Year

Aminoglutethimide (Elipten-Ciba) as an inhibitor of adrenal steroidogenesis: mechanism of action and therapeutic trial.

The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:9

Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Adult; Aminoglutethimide; Animals; Anticonvulsants; Breast Neoplasms; Child; Cholesterol; Clinical Trials as Topic; Cushing Syndrome; Enzyme Therapy; Enzymes; Epilepsy, Absence; Female; Humans; Lyases; Male; Middle Aged; Neoplasm Metastasis; Pregnenolone; Rats

1967

Other Studies

78 other study(ies) available for aminoglutethimide and pregnenolone

Article	Year
Electron paramagnetic resonance spectra of mitochondrial and microsomal cytochrome P-450 from the rat adrenal. Biochimica et biophysica acta, 1976, Oct-13, Volume: 449, Issue:1 Topics: Adrenal Glands; Aminoglutethimide; Animals; Calcium; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Electron Spin Resonance Spectroscopy; Female; Hydrogen-Ion Concentration; Isocitrates; Metyrapone; Microsomes; Mitochondria; Pregnenolone; Rats; Succinates	1976
Estimation of pregnenolone synthesis in rat adrenal homogenates: some cofactor requirements: effects of stress, hypophysectomy, cortisone and ACTH. Endokrinologie, 1977, Volume: 69, Issue:1 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Calcium; Cortisone; Cyanoketone; Female; Hypophysectomy; NADP; Pregnenolone; Rats; Serum Albumin, Bovine; Stress, Physiological	1977
Cytochrome P-450 of adrenal mitochondria. Spin states as detected by difference spectroscopy. The Journal of biological chemistry, 1975, Jun-25, Volume: 250, Issue:12 Topics: Adrenal Glands; Aminoglutethimide; Animals; Binding Sites; Cholesterol; Cycloheximide; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Female; Hydroxysteroids; Kinetics; Mitochondria; Pregnenolone; Protein Binding; Protein Conformation; Rats; Species Specificity; Spectrophotometry; Spectrophotometry, Ultraviolet; Stress, Physiological	1975
Adrenal cholesterol uptake from plasma lipoproteins: regulation by corticotropin. Proceedings of the National Academy of Sciences of the United States of America, 1976, Volume: 73, Issue:12 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Apolipoproteins; Biological Transport; Cholesterol; Kinetics; Lipoproteins; Lipoproteins, HDL; Mitochondria; Pregnenolone; Rats; Temperature	1976
Response of adrenal tumor cells to adrenocorticotropin: site of inhibition by cytochalasin B. Biochemistry, 1977, Jul-12, Volume: 16, Issue:14 Topics: 20-alpha-Dihydroprogesterone; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Biological Transport; Bucladesine; Cholesterol; Cytochalasin B; Cytochrome P-450 Enzyme System; Drug Interactions; Mice; Mitochondria; Pregnenolone; Progesterone; Protein Biosynthesis	1977
On the role of protein synthesis in the response of adrenal tumor cells to ACTH. Molecular and cellular endocrinology, 1978, Volume: 12, Issue:2 Topics: Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aminoglutethimide; Bucladesine; Cell Line; Chloramphenicol; Cholesterol; Cycloheximide; Dactinomycin; Mitochondria; Pregnenolone; Protein Biosynthesis; Puromycin	1978
ACTH stimulates late steps in cortisol biosynthesis. Acta endocrinologica, 1979, Volume: 90, Issue:1 Topics: 17-alpha-Hydroxypregnenolone; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cattle; Cortodoxone; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone	1979
Studies on the regulation of the onset of steroid hormone biosynthesis in fetal rabbit gonads. Endocrinology, 1979, Volume: 105, Issue:5 Topics: Aminoglutethimide; Androgens; Animals; Estradiol; Female; Fetus; Gestational Age; Male; Ovary; Pregnancy; Pregnenolone; Rabbits; Testis	1979
The effects of cytochalasin B and vinblastine on movement of cholesterol in rat adrenal glands. Biochemical and biophysical research communications, 1979, Aug-28, Volume: 89, Issue:4 Topics: Adrenal Glands; Aminoglutethimide; Animals; Cholesterol; Colchicine; Cycloheximide; Cytochalasin B; Female; Hypophysectomy; Kinetics; Pregnenolone; Rats; Vinblastine	1979
Effects of inhibitors of steroid biosynthesis on prostaglandin formation in rabbit ovarian follicles. Prostaglandins, 1979, Volume: 18, Issue:6 Topics: Aminoglutethimide; Androstenols; Animals; Estradiol; Female; Luteinizing Hormone; Metyrapone; Ovarian Follicle; Pregnenolone; Progesterone; Prostaglandins E; Prostaglandins F; Rabbits; Spiro Compounds; Testosterone	1979
Control of sterol metabolism in rat adrenal mitochondria. The Biochemical journal, 1978, Sep-15, Volume: 174, Issue:3 Topics: Adrenal Glands; Aminoglutethimide; Animals; Cycloheximide; Cytochrome P-450 Enzyme System; Female; Mitochondria; Pregnenolone; Rats; Sterols; Stress, Physiological; Structure-Activity Relationship	1978
Angiotensin stimulates both early and late steps in aldosterone biosynthesis in isolated bovine glomerulosa cells. Journal of steroid biochemistry, 1978, Volume: 9, Issue:10 Topics: Adrenal Cortex; Aldosterone; Aminoglutethimide; Angiotensins; Animals; Cattle; Corticosterone; Desoxycorticosterone; Hydrocortisone; Kinetics; Pregnenolone	1978
Ligand modification of corpus luteum mitochondrial cytochrome P-450 spectra and cholesterol monooxygenation: an assay of enzyme-specific inhibitors. Biochemistry, 1977, Feb-22, Volume: 16, Issue:4 Topics: Aminoglutethimide; Animals; Binding Sites; Cattle; Cholesterol; Corpus Luteum; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Enzyme Inhibitors; Female; Kinetics; Ligands; Mitochondria; Oxygenases; Pregnenes; Pregnenolone; Protein Binding; Spectrophotometry	1977
Gonadotrophin stimulation of progesterone synthesis by midpregnancy mouse ovarian cells in vitro. Endocrinology, 1976, Volume: 99, Issue:3 Topics: Aminoglutethimide; Animals; Cells, Cultured; Chorionic Gonadotropin; Female; Kinetics; Male; Mice; Mice, Inbred Strains; Ovary; Pregnancy; Pregnenolone; Progesterone	1976
Implication of ligand modified spectra of cytochrome P-450 associated with pregnenolone synthesis in mitochondria from corpus luteum. Advances in experimental medicine and biology, 1975, Volume: 58, Issue:00 Topics: Aminoglutethimide; Animals; Benzyl Compounds; Carbon Monoxide; Cattle; Cholesterol; Cholic Acids; Corpus Luteum; Cyanoketone; Cytochrome P-450 Enzyme System; Female; Hydroxycholesterols; Imidazoles; Ligands; Mitochondria; Oxidoreductases; Pregnenolone; Spectrum Analysis	1975
Gestation length in rabbits-effect of aminoglutethimide phosphate, dexamethasone, pregnenolone and progesterone. Journal of animal science, 1976, Volume: 42, Issue:1 Topics: Adrenal Glands; Aminoglutethimide; Animals; Animals, Newborn; Corpus Luteum; Dexamethasone; Female; Labor, Obstetric; Nesting Behavior; Organ Size; Ovary; Pregnancy; Pregnancy, Animal; Pregnenolone; Progesterone; Rabbits; Time Factors	1976
Calmidazolium is a potent stimulator of steroidogenesis via mechanisms not involving cyclic AMP, calcium or protein synthesis. The Biochemical journal, 1992, Jan-01, Volume: 281 ( Pt 1) Topics: Adrenal Cortex; Aminoglutethimide; Animals; Bucladesine; Calcium; Calmodulin; Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Egtazic Acid; Imidazoles; Kinetics; Lanthanum; Leydig Cells; Luteinizing Hormone; Male; Mice; Pregnenolone; Protein Biosynthesis; Rats; Rats, Inbred Strains; Testosterone	1992
Cholesterol pools in rat adrenal mitochondria: use of cholesterol oxidase to infer a complex pool structure. Endocrinology, 1992, Volume: 130, Issue:3 Topics: Adrenal Cortex; Aminoglutethimide; Animals; Cell Fractionation; Cholesterol; Cholesterol Oxidase; Female; Intracellular Membranes; Mitochondria; Pregnenolone; Rats; Rats, Inbred Strains	1992
Participation of the cytoskeleton in avian granulosa cell steroidogenesis. General and comparative endocrinology, 1991, Volume: 82, Issue:3 Topics: Aminoglutethimide; Androstenols; Animals; Chickens; Colchicine; Colforsin; Cyclic AMP; Cytochalasin B; Cytochalasin D; Cytoskeleton; Female; Granulosa Cells; Hydroxycholesterols; Luteinizing Hormone; Pregnenolone; Progesterone	1991
Steroidogenesis in interstitial cells and microsomal fraction of immature pig testes. Journal of reproduction and fertility, 1991, Volume: 91, Issue:1 Topics: 17-alpha-Hydroxypregnenolone; Aminoglutethimide; Androgens; Androstenes; Animals; Bucladesine; Cholera Toxin; Chorionic Gonadotropin; Dehydroepiandrosterone; Male; Microsomes; Pregnenolone; Swine; Testis	1991
Heterogeneous pools of cholesterol side-chain cleavage activity in adrenal mitochondria from adrenocorticotropic hormone-treated rats: reconstitution of the isocitrate response with succinate and low concentrations of isocitrate. Archives of biochemistry and biophysics, 1990, Volume: 283, Issue:2 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cholesterol Side-Chain Cleavage Enzyme; Cycloheximide; Isocitrates; Kinetics; Mitochondria; Oligomycins; Oxidative Phosphorylation; Pregnenolone; Rats; Succinates	1990
Generation of regulatory oxysterols: 26-hydroxylation of cholesterol by ovarian mitochondria. Endocrinology, 1990, Volume: 127, Issue:2 Topics: Aminoglutethimide; Animals; Cells, Cultured; Cholestanetriol 26-Monooxygenase; Cholesterol; Chorionic Gonadotropin; Female; Gas Chromatography-Mass Spectrometry; Gonadotropins, Equine; Granulosa Cells; Humans; Hydroxycholesterols; Hydroxylation; Kinetics; Mitochondria; Models, Biological; Pregnenolone; Progesterone; Rats; Steroid Hydroxylases; Sterols; Superovulation	1990
Neurosteroids: steroidogenesis in primary cultures of rat glial cells after release of aminoglutethimide blockade. Biochemical and biophysical research communications, 1989, Jun-15, Volume: 161, Issue:2 Topics: Aminoglutethimide; Animals; Cells, Cultured; Cholesterol; Dexamethasone; In Vitro Techniques; Mevalonic Acid; Neuroglia; Pregnenolone; Rats; Steroids	1989
An endogenous digitalis-factor derived from the adrenal gland: studies of adrenocortical tumor cells. Endocrinology, 1989, Volume: 125, Issue:5 Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Animals; Blood Proteins; Cardenolides; Cell Line; Digoxin; Erythrocyte Membrane; Humans; Kinetics; Mice; Ouabain; Pregnenolone; Radioimmunoassay; Saponins	1989
ACTH control of cholesterol side-chain cleavage at adrenal mitochondrial cytochrome P-450scc. Regulation of intramitochondrial cholesterol transfer. Molecular and cellular endocrinology, 1987, Volume: 53, Issue:1-2 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Cycloheximide; Cyclophosphamide; Cytochrome P-450 Enzyme System; Female; Intracellular Membranes; Kinetics; Mitochondria; Pregnenolone; Rats	1987
Synergistic stimulation of pregnenolone synthesis in rat adrenal mitochondria by n-hexane and cardiolipin. Archives of biochemistry and biophysics, 1988, Feb-01, Volume: 260, Issue:2 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cardiolipins; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Cycloheximide; Drug Synergism; Female; Hexanes; Isocitrates; Kinetics; Mitochondria; NADP; Pregnenolone; Rats	1988
Estrogen increases precursor for pregnenolone synthesis with temperature-sensitive occupancy of P-450scc in mitochondria of rabbit corpus luteum. Endocrinology, 1988, Volume: 122, Issue:5 Topics: Aminoglutethimide; Animals; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Corpus Luteum; Electron Spin Resonance Spectroscopy; Estradiol; Female; Kinetics; Mitochondria; Pregnenolone; Progesterone; Rabbits; Thermodynamics	1988
Steroidogenesis in Fundulus heteroclitus. I. Production of 17 alpha-hydroxy,20 beta-dihydroprogesterone, testosterone, and 17 beta-estradiol by prematurational follicles in vitro. General and comparative endocrinology, 1989, Volume: 73, Issue:1 Topics: 20-alpha-Dihydroprogesterone; Aminoglutethimide; Animals; Culture; Cyprinodontiformes; Dihydrotestosterone; Estradiol; Female; Hydroxycholesterols; Killifishes; Ovarian Follicle; Pregnenolone; Progesterone; Radioimmunoassay; Testosterone	1989
The rise in testicular androgens during the first days of treatment with an LHRH agonist in the dog can be blocked by aminoglutethimide or ketoconazole. Journal of steroid biochemistry, 1988, Volume: 31, Issue:6 Topics: Aldehyde-Lyases; Aminoglutethimide; Androgens; Animals; Cytochrome P-450 Enzyme Inhibitors; Dogs; Estradiol; Flutamide; Gonadotropin-Releasing Hormone; Ketoconazole; Luteinizing Hormone; Male; Pregnenolone; Progesterone; Steroid 17-alpha-Hydroxylase; Testis; Testosterone; Triptorelin Pamoate	1988
Selective inhibition of cholesterol side-chain cleavage by potential pro-drug forms of aminoglutethimide. Anti-cancer drug design, 1988, Volume: 3, Issue:3 Topics: Aminoglutethimide; Animals; Aromatase Inhibitors; Cattle; Cholesterol Side-Chain Cleavage Enzyme; Humans; In Vitro Techniques; Lyases; Pregnenolone; Prodrugs; Progesterone; Steroid 17-alpha-Hydroxylase; Structure-Activity Relationship	1988
Brain mitochondrial cytochrome P-450scc: spectral and catalytic properties. Archives of biochemistry and biophysics, 1987, May-01, Volume: 254, Issue:2 Topics: Aminoglutethimide; Animals; Brain; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Desoxycorticosterone; Male; Mitochondria; NADP; Oxidation-Reduction; Oxidoreductases; Pregnenolone; Rats; Rats, Inbred Strains; Spectrophotometry	1987
Cholesterol sulfate inhibits adrenal mitochondrial cholesterol side chain cleavage at a site distinct from cytochrome P-450scc. Evidence for an intramitochondrial cholesterol translocator. The Journal of biological chemistry, 1987, Jul-05, Volume: 262, Issue:19 Topics: Adrenal Glands; Aminoglutethimide; Animals; Cattle; Cholesterol; Cholesterol Esters; Cholesterol Side-Chain Cleavage Enzyme; Hydroxycholesterols; Mitochondria; Oxidoreductases; Pregnenolone; Sonication	1987
Effect of ketoconazole (an imidazole antimycotic agent) and other inhibitors of steroidogenesis on cytochrome P450-catalyzed reactions. Journal of steroid biochemistry, 1986, Volume: 24, Issue:1 Topics: 18-Hydroxycorticosterone; Adrenal Cortex; Aminoglutethimide; Animals; Cattle; Cholesterol; Corticosterone; Cytochrome P-450 Enzyme Inhibitors; Desoxycorticosterone; Electron Transport; In Vitro Techniques; Ketoconazole; Mitochondria; Pregnenolone; Steroids	1986
Utilization of intramitochondrial membrane cholesterol by cytochrome P-450-dependent cholesterol side-chain cleavage reaction in bovine adrenocortical mitochondria: steroidogenic and non-steroidogenic pools of cholesterol in the mitochondrial inner membra Molecular and cellular endocrinology, 1985, Volume: 40, Issue:2-3 Topics: Adrenal Cortex; Aminoglutethimide; Animals; Cattle; Cell Fractionation; Cholesterol; Cytochrome P-450 Enzyme System; Intracellular Membranes; Malates; Membrane Lipids; Mitochondria; NADP; Pregnenolone; Progesterone; Submitochondrial Particles	1985
Estrogen regulation of steroidogenesis in rabbit luteal cells. Endocrinology, 1985, Volume: 117, Issue:6 Topics: 20-alpha-Dihydroprogesterone; Aminoglutethimide; Animals; Corpus Luteum; Cytochrome P-450 Enzyme System; Estradiol; Female; Hydroxycholesterols; Pregnenolone; Progesterone; Pseudopregnancy; Rabbits; Superovulation; Time Factors	1985
Mitochondrial steroid metabolism in the inner and outer zones of the guinea-pig adrenal cortex. Journal of steroid biochemistry, 1985, Volume: 23, Issue:4 Topics: Adrenal Cortex; Adrenal Cortex Hormones; Aminoglutethimide; Animals; Cytochrome b Group; Cytochrome P-450 Enzyme System; Cytochromes b5; Guinea Pigs; In Vitro Techniques; Male; Metyrapone; Mitochondria; Pregnenolone	1985
Subcellular localisation of adrenal cholesterol by autoradiography and digitonin reaction after aminoglutethimide-induced inhibiton of corticosterone synthesis. Histochemie. Histochemistry. Histochimie, 1974, Mar-06, Volume: 38, Issue:3 Topics: Adrenal Glands; Aminoglutethimide; Animals; Autoradiography; Cholesterol; Chromatography, Thin Layer; Corticosterone; Depression, Chemical; Digitonin; Histocytochemistry; Male; Microscopy, Electron; Microscopy, Polarization; Mitochondria; Pregnenolone; Staining and Labeling; Tritium	1974
Inhibition of adrenal corticosteroid synthesis by aminoglutethimide: studies of the mechanism of action. The Journal of clinical endocrinology and metabolism, 1967, Volume: 27, Issue:4 Topics: Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Anticonvulsants; Cholesterol; Corticosterone; Enzymes; Hypophysectomy; In Vitro Techniques; Male; Pituitary Gland; Pregnenolone; Protein Biosynthesis; Rats; Secretory Rate	1967
Inhibition of adrenal cortical secretion by amino-glutethimide in dogs. Endocrinology, 1968, Volume: 83, Issue:1 Topics: 17-alpha-Hydroxypregnenolone; 17-Hydroxycorticosteroids; Adrenal Cortex Hormones; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Chromatography, Paper; Corticosterone; Dehydroepiandrosterone; Depression, Chemical; Desoxycorticosterone; Dogs; Hydrocortisone; Hydroxyprogesterones; Pregnenolone; Progesterone; Pyridones; Veins	1968
Inhibition of adrenal steroidogenesis by glutethimide. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 129, Issue:1 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Body Weight; Cholesterol; Corticosterone; Desoxycorticosterone; Female; Glutethimide; Hydroxyprogesterones; In Vitro Techniques; Methods; Organ Size; Pregnenolone; Rats	1968
Adrenal cells in tissue culture. IV. Use of an inhibitor of steroid synthesis for the study of ACTH action. Endocrinology, 1969, Volume: 85, Issue:2 Topics: Acetates; Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Carbon Isotopes; Cell-Free System; Cholesterol; Culture Techniques; Depression, Chemical; Feedback; Glucose; Glycolysis; Hydroxysteroid Dehydrogenases; Mice; Mixed Function Oxygenases; Pregnenolone; Pyridones; Rats; Stimulation, Chemical; Tritium	1969
Stimulation of adrenal cholesterol uptake from plasma by adrenocorticotrophin. Endocrinology, 1970, Volume: 87, Issue:5 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Carbon Isotopes; Cholesterol; Cycloheximide; Depression, Chemical; Hydrocortisone; Hypophysectomy; Male; Pregnenolone; Protein Biosynthesis; Rats; Stimulation, Chemical; Tritium	1970
Stimulation of steroid secretion by antimicrotubular agents. The Journal of biological chemistry, 1973, Apr-25, Volume: 248, Issue:8 Topics: Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cell Line; Chromatography, Thin Layer; Colchicine; Cyclic AMP; Deuterium; Hydroxysteroids; Ketosteroids; Leydig Cell Tumor; Mice; Microtubules; Mitosis; Podophyllotoxin; Pregnenes; Pregnenolone; Protein Biosynthesis; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet; Stimulation, Chemical; Time Factors; Vinblastine	1973
The mechanism of action of adrenocroticotropic hormone. The role of mitochondrial cholesterol accumulation in the regulation of steroidogenesis. The Journal of biological chemistry, 1974, Jan-10, Volume: 249, Issue:1 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Bucladesine; Cholesterol; Chromatography, Gas; Cyclic AMP; Cycloheximide; Cytosol; Hypophysectomy; Male; Microscopy, Electron; Mitochondria; Pituitary Gland; Pregnenolone; Rats; Subcellular Fractions; Swine; Time Factors	1974
A possible mechanism for the stimulation of Krebs cycle activity by ACTH in isolated rat adrenal cells. Biochemical and biophysical research communications, 1974, Jun-18, Volume: 58, Issue:4 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Bucladesine; Carbon Dioxide; Carbon Radioisotopes; Citric Acid Cycle; Corticosterone; In Vitro Techniques; Kinetics; Microbial Collagenase; Pregnenolone; Progesterone; Pyruvates; Rats; Trypsin	1974
Observations on the influence of ACTH on adrenal cholesterol metabolism. Transactions of the American Clinical and Climatological Association, 1974, Volume: 85 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Bucladesine; Cholesterol; Culture Techniques; Cyclic AMP; Hypophysectomy; Male; Mitochondria; Pregnenolone; Rats	1974
The detection of different states of the P-450 cytochromes in adrenal mitochondria: changes induced by ACTH. Annals of the New York Academy of Sciences, 1973, Volume: 212 Topics: Adrenal Cortex; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cattle; Chemical Phenomena; Chemistry; Cholesterol; Cytochrome P-450 Enzyme System; Electron Spin Resonance Spectroscopy; Hydrogen-Ion Concentration; Mitochondria; Pregnenolone; Rats; Stress, Physiological; Structure-Activity Relationship	1973
Aminoglutethimide inhibition of adrenal desmolase activity. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1968, Volume: 127, Issue:4 Topics: Adrenal Glands; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Cholesterol; Depression, Chemical; Glutethimide; Kinetics; Lyases; NADP; Pregnenolone; Pyridones; Rats	1968
3',5'-cyclic AMP and the adrenal desmolase system. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1969, Volume: 131, Issue:4 Topics: Adenine Nucleotides; Adrenal Glands; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Carbon Isotopes; Cholesterol; Cyclic AMP; Guinea Pigs; Lyases; NADP; Pregnenolone; Sterols; Tritium	1969
Effects of aminoglutethimide, metyrapone, and ascorbic acid on testicular metabolism of cholesterol. Metabolism: clinical and experimental, 1974, Volume: 23, Issue:12 Topics: Aminoglutethimide; Androstanes; Androstenedione; Animals; Ascorbic Acid; Carbon Radioisotopes; Cell-Free System; Cholesterol; Chromatography, Paper; Chromatography, Thin Layer; Female; Hydroxyprogesterones; Hydroxysteroids; Male; Metyrapone; Mitochondria; Pregnenolone; Progesterone; Rats; Testis; Testosterone; Tritium	1974
Failure of aminoglutethimide to produce changes in morphology and steroid biosynthesis of rat testicles. Endocrinologia experimentalis, 1972, Volume: 6, Issue:3 Topics: 17-Ketosteroids; Aminoglutethimide; Androstanes; Aniline Compounds; Animals; Anticonvulsants; Biotransformation; Cholesterol; Glucocorticoids; Histocytochemistry; Hydroxyprogesterones; Leydig Cells; Male; Pregnenolone; Progesterone; Pyridones; Rats; Testis; Testosterone	1972
Effect of exogenous steroids and inhibitors of steroidogenesis on endotoxin shock. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1973, Volume: 142, Issue:2 Topics: Adrenal Cortex Hormones; Adrenal Glands; Aminoglutethimide; Androstenedione; Animals; Butanones; Corticosterone; Desoxycorticosterone; Endotoxins; Hydrocortisone; Hydroxyprogesterones; Lethal Dose 50; Male; Metyrapone; Mice; Mice, Inbred ICR; Pregnenes; Pregnenolone; Progesterone; Shock, Septic	1973
Oxidation of 20 -hydroxycholesterol by adrenal cortex mitochondria. The Journal of biological chemistry, 1973, Jan-10, Volume: 248, Issue:1 Topics: Adrenal Glands; Aminoglutethimide; Animals; Antimycin A; Cattle; Cholesterol; Chromatography, Paper; Cyanides; Malates; Metyrapone; Mitochondria; Oxygen Consumption; Pregnenolone; Spectrophotometry; Succinates; Tritium	1973
Proceedings: Effects of aminoglutethimide and SU 10'603 on the biosynthesis of C19 steroids. The Journal of endocrinology, 1974, Volume: 61, Issue:1 Topics: Aminoglutethimide; Androstenedione; Animals; Carbon Radioisotopes; Cholesterol; In Vitro Techniques; Male; Mixed Function Oxygenases; Naphthalenes; Pregnenolone; Progesterone; Pyridines; Rats; Steroids; Swine; Testis; Testosterone	1974
The influence of an anti-steroidogenic drug (aminoglutethimide phosphate) on pregnancy maintenance. Endocrinology, 1972, Volume: 90, Issue:5 Topics: Abortion, Induced; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Biotransformation; Cholesterol; Corpus Luteum; Depression, Chemical; Female; Male; Methods; Pregnancy; Pregnancy, Animal; Pregnenolone; Progesterone; Protein Binding; Pyridones; Rats; Tritium	1972
Inhibition of cholesterol side-chain cleavage by azacholesterols. Biochemical pharmacology, 1971, Volume: 20, Issue:10 Topics: Adrenal Glands; Aminoglutethimide; Animals; Cattle; Chemosterilants; Cholesterol; Depression, Chemical; Mitochondria; Nitrogen; Pregnenolone; Sterols	1971
[Aminoglutethimide-induced lipoid transformation of mitochondria in the adrenal cortex]. Die Naturwissenschaften, 1970, Volume: 57, Issue:5 Topics: Adrenal Glands; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Cholesterol; Histocytochemistry; Lipid Metabolism; Microscopy, Electron; Mitochondria; Mitochondrial Swelling; Pregnenolone; Pyridones; Rats	1970
Production of congenital lipoid adrenal hyperplasia in rats and inhibition of cholesterol side-chain cleavage. Endocrinology, 1970, Volume: 86, Issue:6 Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Aminoglutethimide; Aniline Compounds; Animals; Anticonvulsants; Cholesterol; Disease Models, Animal; Female; Glutethimide; Hydroxysteroid Dehydrogenases; Lyases; Male; Maternal-Fetal Exchange; Organ Size; Ovary; Pregnancy; Pregnancy, Animal; Pregnenolone; Pyridones; Rats; Testis; Virilism	1970
On the specificity of the inhibitory effect of trilostane and aminoglutethimide on adrenocortical steroidogenesis in guinea pig. Molecular and cellular endocrinology, 1984, Volume: 37, Issue:1 Topics: 17-alpha-Hydroxypregnenolone; 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenocorticotropic Hormone; Aminoglutethimide; Animals; Cortodoxone; Dihydrotestosterone; Guinea Pigs; Hydrocortisone; Hydroxyprogesterones; Male; Pregnenolone; Progesterone	1984
Characterization of the desensitized state of Leydig tumor cells. Biochimica et biophysica acta, 1981, Jul-17, Volume: 675, Issue:3-4 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aminoglutethimide; Animals; Cell Line; Cholera Toxin; Cholesterol; Cholesterol Esters; Chorionic Gonadotropin; Cyclic AMP; Leydig Cell Tumor; Mice; Pregnenolone; Steroids	1981
An early steroidogenic defect in hormone-induced Leydig cell desensitization. Journal of steroid biochemistry, 1984, Volume: 21, Issue:3 Topics: Adrenal Glands; Aminoglutethimide; Animals; Antimycin A; Caproates; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Chromatography, Affinity; Chromatography, Gel; Cytosol; Hot Temperature; Hydroxycholesterols; Isoelectric Focusing; Leydig Cells; Male; Mitochondria; Pregnenolone; Rats; Rats, Inbred Strains; Rotenone; Sonication; Time Factors	1984
Inhibition of steroidogenesis in cultured Leydig tumor cells by 22-amino-23,24-bisnor-5-cholen-3 beta-O1 and (20R) 20-phenyl-5-pregnene-3 beta,20-diol. Endocrinology, 1983, Volume: 113, Issue:1 Topics: Aminoglutethimide; Animals; Cattle; Cholesterol; Chorionic Gonadotropin; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Leydig Cell Tumor; Male; Pregnenes; Pregnenolone; Progesterone; Testicular Neoplasms; Time Factors	1983
Effects of cholesterol side chain cleavage inhibitors on 11 beta-hydroxylation: linkage of mitochondrial oxygenase systems. Steroids, 1981, Volume: 37, Issue:6 Topics: Adrenal Cortex; Aminoglutethimide; Androstenols; Animals; Cattle; Cholesterol Side-Chain Cleavage Enzyme; Cortodoxone; Cyanoketone; Hydrocortisone; Mitochondria; Oxidoreductases; Pregnenolone; Steroid 11-beta-Hydroxylase; Steroid Hydroxylases	1981
Interaction between two luteal cell types from the corpus luteum of the sow in progesterone synthesis in vitro. Journal of reproduction and fertility, 1982, Volume: 64, Issue:2 Topics: Abortifacient Agents, Steroidal; Aminoglutethimide; Animals; Cells, Cultured; Cholesterol; Corpus Luteum; Dihydrotestosterone; Female; Luteal Cells; Perfusion; Pregnancy; Pregnenolone; Progesterone; Swine	1982
The effect of ether stress and cycloheximide treatment on cholesterol binding and enzyme turnover of adrenal cortical cytochrome P450scc. Journal of steroid biochemistry, 1982, Volume: 16, Issue:6 Topics: Adrenal Cortex; Aminoglutethimide; Animals; Cholesterol; Cycloheximide; Cytochrome P-450 Enzyme System; Ether; Female; Mitochondria; Oxygen; Pregnenolone; Rats; Rats, Inbred Strains; Spectrophotometry; Stress, Physiological	1982
Effects of aminoglutethiumide and its metabolite, N-acetylaminoglutethimide, on bovine adrenocortical and human placental cytochromes P-450scc. Naunyn-Schmiedeberg's archives of pharmacology, 1982, Volume: 321, Issue:1 Topics: Adrenal Cortex; Aminoglutethimide; Animals; Cattle; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Female; Humans; Mitochondria; Permeability; Placenta; Pregnancy; Pregnenolone; Stereoisomerism	1982
A relationship between adenosine 5'-triphosphate and pregnenolone syntheses by ovarian mitochondria as demonstrated with aminoglutethimide. Endocrinology, 1980, Volume: 106, Issue:5 Topics: Adenosine Triphosphate; Aging; Aminoglutethimide; Animals; Dose-Response Relationship, Drug; Female; Hypophysectomy; Kinetics; Mitochondria; Ovary; Oxidative Phosphorylation; Oxygen Consumption; Pregnenolone	1980
Medical adrenalectomy may replace surgery for advanced breast cancer. JAMA, 1980, Jul-04, Volume: 244, Issue:1 Topics: Adipose Tissue; Adrenal Glands; Adrenalectomy; Aminoglutethimide; Androstenedione; Breast Neoplasms; Cholesterol; Estradiol; Estrogen Antagonists; Female; Humans; Pregnenolone	1980
Glucocorticoids enhance the cholesterol side-chain cleavage activity of ovine adrenocortical mitochondria. The Journal of steroid biochemistry and molecular biology, 1995, Volume: 55, Issue:1 Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adrenodoxin; Aminoglutethimide; Animals; Calcium Chloride; Cells, Cultured; Cholesterol; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dexamethasone; Enzyme Inhibitors; Ferredoxin-NADP Reductase; Glucocorticoids; Hydroxycholesterols; Metyrapone; Mitochondria; Pregnenolone; RNA, Messenger; Sheep; Steroids	1995
Neurosteroidogenesis in rat retinas. Journal of neurochemistry, 1994, Volume: 63, Issue:1 Topics: Aminoglutethimide; Animals; Central Nervous System; Cholesterol Side-Chain Cleavage Enzyme; Chromatography, High Pressure Liquid; Cyclic AMP; Dehydroepiandrosterone; Dose-Response Relationship, Drug; Gas Chromatography-Mass Spectrometry; Immunohistochemistry; Lovastatin; Male; Neurotransmitter Agents; Pregnenolone; Progesterone; Rats; Rats, Wistar; Retina; Steroids; Time Factors	1994
The interaction of biogenic amines with adrenal cytochrome P450-dependent enzymes. Biochemical Society transactions, 1993, Volume: 21, Issue:4 Topics: Adrenal Cortex; Aminoglutethimide; Animals; Biogenic Amines; Cattle; Cell Line; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 Enzyme System; Desoxycorticosterone; Isoenzymes; Metanephrine; Microsomes; Pregnenolone; Progesterone; Sheep; Transfection	1993
Competition for electron transfer between cytochromes P450scc and P45011 beta in rat adrenal mitochondria. Molecular and cellular endocrinology, 1993, Volume: 95, Issue:1-2 Topics: Adrenal Cortex; Adrenodoxin; Aminoglutethimide; Animals; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Cosyntropin; Desoxycorticosterone; Electron Transport; Female; Ferredoxin-NADP Reductase; Isocitrates; Isoenzymes; Metyrapone; Mitochondria; NADP; Oxidation-Reduction; Pregnenolone; Rats; Rats, Sprague-Dawley; Steroid 11-beta-Hydroxylase; Succinates; Succinic Acid	1993
Estrogen-mediated mitochondrial cholesterol transport and metabolism to pregnenolone in the rabbit luteinized ovary. Biology of reproduction, 1997, Volume: 57, Issue:2 Topics: Aminoglutethimide; Animals; Biological Transport; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Corpus Luteum; Enzyme Inhibitors; Estradiol; Female; Kinetics; Mitochondria; Ovary; Pregnenolone; Rabbits	1997
Aminoglutethimide, a corticosteroid synthesis inhibitor, facilitates brain stimulation reward in food-restricted rats: an investigation of underlying mechanisms. Psychopharmacology, 1997, Volume: 133, Issue:4 Topics: Adrenal Cortex Hormones; Adrenalectomy; Aminoglutethimide; Animals; Brain; Corticosterone; Enzyme Inhibitors; Food Deprivation; Male; Pregnenolone; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Reward; Self Stimulation	1997
Detection of P450c17-independent pathways for dehydroepiandrosterone (DHEA) biosynthesis in brain glial tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 1998, Mar-17, Volume: 95, Issue:6 Topics: Aminoglutethimide; Animals; Brain Neoplasms; Cholesterol Side-Chain Cleavage Enzyme; Cytochrome P-450 Enzyme System; Dehydroepiandrosterone; Ferrous Compounds; Glioma; Leydig Cells; Male; Microsomes; Models, Chemical; Neuroglia; Pregnenolone; Rats; Steroid 17-alpha-Hydroxylase; Tetrahydronaphthalenes; Tumor Cells, Cultured	1998
Synthesis of steroids in pancreas: evidence of cytochrome P-450scc activity. Pancreas, 1999, Volume: 19, Issue:1 Topics: Aminoglutethimide; Animals; Biotransformation; Cell Fractionation; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; DNA Primers; Dogs; Male; Mitochondria; Nucleotide Mapping; Pancreas; Pregnenolone; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger	1999
Regulatory role of cytochrome P450scc and pregnenolone in myelination by rat Schwann cells. Molecular and cellular biochemistry, 2008, Volume: 313, Issue:1-2 Topics: Aminoglutethimide; Animals; Cell Differentiation; Cholesterol Side-Chain Cleavage Enzyme; Gene Expression Regulation; Myelin Basic Protein; Myelin P0 Protein; Myelin Sheath; Phenotype; Pregnenolone; Rats; Rats, Sprague-Dawley; RNA, Messenger; Schwann Cells; Up-Regulation	2008
The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells. The Journal of biological chemistry, 2022, Volume: 298, Issue:7 Topics: Aminoglutethimide; Cholesterol; Cholesterol Side-Chain Cleavage Enzyme; Humans; Ketoconazole; Neuroglia; Neurosteroids; Pregnenolone; Reactive Oxygen Species	2022