aminoglutethimide and letrozole

aminoglutethimide has been researched along with letrozole in 31 studies

Research

Studies (31)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	13 (41.94)	18.2507
2000's	12 (38.71)	29.6817
2010's	5 (16.13)	24.3611
2020's	1 (3.23)	2.80

Authors

Authors	Studies
Balunas, MJ; Brueggemeier, RW; Kinghorn, AD; Landini, S; Su, B	1
Bilter, GK; Dias, J; Huang, Z; Keon, BH; Lamerdin, J; MacDonald, ML; Michnick, SW; Minami, T; Owens, S; Shang, Z; Westwick, JK; Yu, H	1
Balunas, MJ; Brueggemeier, RW; Kinghorn, AD; Su, B	1
Hartmann, RW; Le Borgne, M; Lézé, MP; Palusczak, A	1
Muftuoglu, Y; Mustata, G	1
Buxeraud, J; Chulia, AJ; Fagnère, C; Pouget, C; Yahiaoui, S	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ	1
Chen, JZ; Khan, MZI; Nazli, A; Uzair, M	1
Borja, J; Pérez, N	1
Manni, A	1
Dowsett, M	2
Buzdar, AU; Roseman, BJ; Singletary, SE	1
Harvey, HA	1
Smith, IE	2
Bodrogi, I; Bonaventura, A; Buzzi, F; Campos, D; Chaudri, HA; Friederich, P; Gershanovich, M; Jeffrey, M; Lassus, M; Ludwig, H; Lurie, H; O'Higgins, N; Reichardt, P; Romieu, G	1
Blijham, GH; de Jong, PC	1
Bodrogi, I; Bonaventura, A; Buzzi, F; Campos, D; Chaudri, Kh; Friedrich, P; Gershanovich, M; Jeffrey, M; Lassus, M; Ludwig, H; Lurie, H; O'Higgins, NO; Reichard, P; Romieu, G	1
Bonneterre, J; Feutrie, ML	1
Harvey, HA; Santen, RJ	1
Auvray, P; Bichat, F; Genne, P	1
de Crémoux, P	1
Buzdar, AU	1
Benedetto, C; De Nicola, B; Ferraris, F; Genta, F; Piccinno, R; Porpiglia, M; Vicelli, R	1
Rose, C	1
Cernich, J; Jacobson, JD; Moore, WV; Popovic, J	1
Ioannidis, JP; Mauri, D; Pavlidis, N; Polyzos, NP	1
Dutta, U; Pant, K	1
Chen, T; Chu, F; Gong, Y; Lei, H; Liu, X; Lu, F; Xing, Y; Xu, B; Yan, M	1

Reviews

19 review(s) available for aminoglutethimide and letrozole

Article	Year
An overview on Estrogen receptors signaling and its ligands in breast cancer. European journal of medicinal chemistry, 2022, Nov-05, Volume: 241 Topics: Breast Neoplasms; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Humans; Ligands; Male; Receptors, Estrogen	2022
Aromatase inhibitors: clinical pharmacology and therapeutic implications in breast cancer. The Journal of international medical research, 1992, Volume: 20, Issue:4 Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Letrozole; Nitriles; Triazoles	1992
Clinical use of aromatase inhibitors in the treatment of breast cancers. Journal of cellular biochemistry. Supplement, 1993, Volume: 17G Topics: Aminoglutethimide; Animals; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Nitriles; Rats; Triazoles	1993
Use of aromatase inhibitors in postmenopausal women with advanced breast cancer. Journal of surgical oncology, 1997, Volume: 66, Issue:3 Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles	1997
Emerging role of aromatase inhibitors in the treatment of breast cancer. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:3 Suppl 5 Topics: Aged; Aminoglutethimide; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Megestrol Acetate; Middle Aged; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Triazoles	1998
Pivotal trials of letrozole: a new aromatase inhibitor. Oncology (Williston Park, N.Y.), 1998, Volume: 12, Issue:3 Suppl 5 Topics: Aminoglutethimide; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Disease-Free Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Treatment Outcome; Triazoles	1998
Theoretical considerations for the ideal aromatase inhibitor. Breast cancer research and treatment, 1998, Volume: 49 Suppl 1 Topics: Aminoglutethimide; Anastrozole; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles	1998
New aromatase inhibitors for the treatment of advanced breast cancer in postmenopausal women. The Netherlands journal of medicine, 1999, Volume: 55, Issue:2 Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Triazoles	1999
[Aromatase inhibitors]. Bulletin du cancer, 1999, Volume: 86, Issue:10 Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estrogen Antagonists; Estrone; Female; Humans; Letrozole; Nitriles; Triazoles	1999
Aromatase inhibitors: a dose-response effect? Endocrine-related cancer, 1999, Volume: 6, Issue:2 Topics: Aminoglutethimide; Anastrozole; Animals; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrogens; Fadrozole; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Triazoles	1999
Use of aromatase inhibitors in breast carcinoma. Endocrine-related cancer, 1999, Volume: 6, Issue:1 Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles	1999
[Preclinical evaluation of aromatase inhibitors antitumor activity]. Bulletin du cancer, 2000, Volume: 87 Spec No Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Models, Animal; Nitriles; Rats; Structure-Activity Relationship; Triazoles	2000
[Aromatase inhibitors: pharmacological aspects]. Bulletin du cancer, 2000, Volume: 87 Spec No Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles	2000
A summary of second-line randomized studies of aromatase inhibitors. The Journal of steroid biochemistry and molecular biology, 2001, Volume: 79, Issue:1-5 Topics: Aminoglutethimide; Anastrozole; Androstadienes; Aromatase Inhibitors; Breast Neoplasms; Drug Tolerance; Enzyme Inhibitors; Estrogen Receptor Modulators; Fadrozole; Female; Humans; Letrozole; Megestrol Acetate; Neoplasms, Hormone-Dependent; Nitriles; Randomized Controlled Trials as Topic; Tamoxifen; Triazoles	2001
[The role of aromatase inhibitors in the treatment of breast neoplasms. An evaluation of clinical efficacy and the tolerability profile]. Minerva ginecologica, 2002, Volume: 54, Issue:2 Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; Enzyme Inhibitors; Female; Follow-Up Studies; Forecasting; Humans; Letrozole; Middle Aged; Nitriles; Randomized Controlled Trials as Topic; Selective Estrogen Receptor Modulators; Tamoxifen; Time Factors; Triazoles	2002
A comparison of the efficacy of aromatase inhibitors in second-line treatment of metastatic breast cancer. American journal of clinical oncology, 2003, Volume: 26, Issue:4 Topics: Aminoglutethimide; Anastrozole; Androstadienes; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Female; Humans; Letrozole; Megestrol Acetate; Neoplasm Metastasis; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Receptors, Estrogen; Tamoxifen; Triazoles	2003
Use of aromatase inhibitors in children with short stature. Pediatric endocrinology reviews : PER, 2004, Volume: 2, Issue:1 Topics: Adult; Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Body Height; Child; Estrogens; Female; Growth Disorders; Humans; Letrozole; Male; Musculoskeletal System; Nitriles; Triazoles	2004
Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis. Journal of the National Cancer Institute, 2006, Sep-20, Volume: 98, Issue:18 Topics: Adult; Aged; Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Odds Ratio; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles	2006
Aromatase inhibitors: past, present and future in breast cancer therapy. Medical oncology (Northwood, London, England), 2008, Volume: 25, Issue:2 Topics: Aminoglutethimide; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles	2008

Trials

3 trial(s) available for aminoglutethimide and letrozole

Article	Year
Letrozole, a new oral aromatase inhibitor: randomised trial comparing 2.5 mg daily, 0.5 mg daily and aminoglutethimide in postmenopausal women with advanced breast cancer. Letrozole International Trial Group (AR/BC3). Annals of oncology : official journal of the European Society for Medical Oncology, 1998, Volume: 9, Issue:6 Topics: Administration, Oral; Aged; Aminoglutethimide; Antineoplastic Agents, Hormonal; Breast Neoplasms; Confidence Intervals; Disease Progression; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Nitriles; Odds Ratio; Postmenopause; Prognosis; Survival Rate; Treatment Failure; Triazoles	1998
[Letrozole (Femara), a new aromatase inhibitor for advanced breast cancer]. Voprosy onkologii, 1999, Volume: 45, Issue:4 Topics: Aged; Aminoglutethimide; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Enzyme Inhibitors; Female; Humans; Letrozole; Middle Aged; Nitriles; Survival Analysis; Treatment Failure; Treatment Outcome; Triazoles	1999
Impact of nonsteroidal aromatase inhibitors on steroid profile in a Chinese population. Medicine, 2017, Volume: 96, Issue:28 Topics: Aminoglutethimide; Anastrozole; Aromatase Inhibitors; Biomarkers, Pharmacological; Doping in Sports; Female; Hormones; Humans; Letrozole; Male; Models, Biological; Nitriles; Single-Blind Method; Steroids; Substance-Related Disorders; Triazoles; Young Adult	2017

Other Studies

9 other study(ies) available for aminoglutethimide and letrozole

Article	Year
Interference by naturally occurring fatty acids in a noncellular enzyme-based aromatase bioassay. Journal of natural products, 2006, Volume: 69, Issue:4 Topics: Aromatase; Biological Products; Breast Neoplasms; Fatty Acids; Female; Humans; Microsomes; Placenta; Tumor Cells, Cultured	2006
Identifying off-target effects and hidden phenotypes of drugs in human cells. Nature chemical biology, 2006, Volume: 2, Issue:6 Topics: Bacterial Proteins; Cell Line; Cell Proliferation; Cluster Analysis; Drug Design; Drug Evaluation, Preclinical; Genetics; Humans; Luminescent Proteins; Molecular Structure; Phenotype; Recombinant Fusion Proteins; Signal Transduction; Structure-Activity Relationship	2006
Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. Journal of natural products, 2008, Volume: 71, Issue:7 Topics: Anticarcinogenic Agents; Aromatase Inhibitors; Dietary Supplements; Dose-Response Relationship, Drug; Garcinia mangostana; Molecular Structure; Xanthones	2008
Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors. Bioorganic & medicinal chemistry letters, 2008, Aug-15, Volume: 18, Issue:16 Topics: Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Gene Expression Regulation, Neoplastic; Hormones; Humans; Indoles; Inhibitory Concentration 50; Models, Chemical; Molecular Structure; Nitriles; Receptors, Estrogen; Steroid 17-alpha-Hydroxylase	2008
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorganic & medicinal chemistry letters, 2010, May-15, Volume: 20, Issue:10 Topics: Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Binding Sites; Breast Neoplasms; Computer Simulation; Drug Design; Female; Humans; Models, Chemical; Models, Molecular; Structure-Activity Relationship	2010
Lead optimization of 4-imidazolylflavans: new promising aromatase inhibitors. European journal of medicinal chemistry, 2011, Volume: 46, Issue:6 Topics: Aromatase; Aromatase Inhibitors; Dose-Response Relationship, Drug; Flavonoids; Humans; Imidazoles; Molecular Structure; Stereoisomerism; Structure-Activity Relationship	2011
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests	2013
Aromatase inhibitors come of age. Annals of oncology : official journal of the European Society for Medical Oncology, 1997, Volume: 8, Issue:7 Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Nitriles; Triazoles	1997