aminoglutethimide has been researched along with formestane in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 20 (32.26) | 18.7374 |
| 1990's | 31 (50.00) | 18.2507 |
| 2000's | 8 (12.90) | 29.6817 |
| 2010's | 2 (3.23) | 24.3611 |
| 2020's | 1 (1.61) | 2.80 |
| Authors | Studies |
|---|---|
| Cole, PA; Robinson, CH | 1 |
| Abul-Hajj, YJ | 3 |
| Brodie, AM; Brodie, HJ; Garrett, W; Marsh, DA; Tsai-Morris, CH | 1 |
| Colombo, G; Dinis, TC; Neves, MA; Sá e Melo, ML | 1 |
| Barmade, MA; Murumkar, PR; Tamboli, RS; Yadav, MR | 1 |
| Egbuta, C; Ghosh, D; Lo, J | 1 |
| Chen, JZ; Khan, MZI; Nazli, A; Uzair, M | 1 |
| Bogart, MH; Lance, VA | 1 |
| Borja, J; Pérez, N | 1 |
| Dowsett, M; Ekse, D; Jacobs, S; Johannessen, DC; Jones, A; Lønning, PE; McNeil, F; Powles, TJ | 1 |
| Anderson, ED; Anderson, TJ; Chetty, U; Forrest, AP; Hawkins, RA; Leonard, RC | 1 |
| Dowsett, M; Lønning, PE; Powles, TJ | 1 |
| Distler, W; von Matthiessen, H | 1 |
| Santen, RJ | 1 |
| Dowsett, M | 2 |
| Chen, SA; Pompon, D; Zhou, DJ | 1 |
| Briatico, G; di Salle, E; Giudici, D; Ornati, G | 1 |
| Bhatnagar, AS; Häusler, A; Krähenbühl, C; Monnet, G; Schenkel, L | 1 |
| Anderson, ED; Chetty, U; Forrest, AP; Hawkins, RA; Levack, PA | 1 |
| Miller, WR | 1 |
| Manni, A; Santen, RJ | 1 |
| Armstrong, DT; Glasier, MA; Khalil, MW; Lang, T; Morley, P | 1 |
| Brodie, AM; Santen, RJ | 1 |
| Ayub, M; Levell, MJ | 1 |
| Miller, WR; O'Neill, J | 1 |
| Feil, PD; Leszczynski, D; Manni, A; Santen, RJ; Santner, SJ; Tilson-Mallet, N; Wright, C | 1 |
| Brodie, AM; Coombes, RC; Dowsett, M; Goss, P; Wing, LY | 1 |
| Coombes, RC; Easton, D; Goss, PE; Singh, D; Wilkinson, JR; Williams, JC | 1 |
| Donahoe, PK; Hutson, JM; MacLaughlin, DT | 1 |
| Brodie, AM; Garrett, WM; Wing, LY | 1 |
| Feil, PD; Santen, RJ; Santner, SJ; Tilson-Mallett, N | 1 |
| Brodie, AM | 2 |
| Covey, DF; Etre, LA; MacIndoe, JH; Woods, GR | 1 |
| Murray, R; Pitt, P | 1 |
| Casebolt, TL; Eto, I; Grubbs, CJ; Kelloff, GJ; Lubet, RA; Steele, VE | 1 |
| Cam, LL; Chen, S; Korzekwa, KR; Laughton, CA; Zhou, D | 1 |
| Bhatnagar, AS; King, EJ; Purba, HS; Richert, P | 1 |
| Dowsett, M; Jacobs, S; Lønning, PE; MacNeill, FA; Powles, TJ | 1 |
| Kanno, H; Kim, T; Kitawaki, J; Noguchi, T; Okada, H; Yamamoto, T | 1 |
| Höffken, K | 1 |
| Ekse, D; Lønning, PE | 1 |
| Boyle, T; Dukes, M; Edwards, PN; Large, M; Smith, IK | 1 |
| Frost, VJ; Helle, SI; Holly, JM; Lønning, PE; van der Stappen, JW | 1 |
| Anker, G; Geisler, J; Johannessen, DC; Lønning, PE | 1 |
| Buzdar, AU; Roseman, BJ; Singletary, SE | 1 |
| Rubens, RD | 1 |
| Anderson, ED; Anderson, TJ; Cameron, DA; Chetty, U; Forrest, AP; Hawkins, RA; Leonard, RC; Levack, P | 1 |
| Anker, GB; Johannessen, DC; Lien, EA; Lonning, PE; Refsum, H; Ueland, PM | 1 |
| Blijham, GH; de Jong, PC | 1 |
| Bonneterre, J; Feutrie, ML | 1 |
| Harvey, HA; Santen, RJ | 1 |
| Bonneterre, J; Mauriac, L | 1 |
| Auvray, P; Bichat, F; Genne, P | 1 |
| de Crémoux, P | 1 |
| Cernich, J; Jacobson, JD; Moore, WV; Popovic, J | 1 |
| Ioannidis, JP; Mauri, D; Pavlidis, N; Polyzos, NP | 1 |
| Fox, J; Hamad, A; Kluk, M; Park, M; Turner, JE | 1 |
| Dutta, U; Pant, K | 1 |
23 review(s) available for aminoglutethimide and formestane
| Article | Year |
|---|---|
Mechanism and inhibition of cytochrome P-450 aromatase.
Topics: Affinity Labels; Aromatase; Aromatase Inhibitors; Binding, Competitive; Humans; Molecular Structure; Photochemistry | 1990 |
Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer.
Topics: Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Female; Humans; Models, Molecular; Molecular Structure | 2015 |
Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.
Topics: Aromatase; Aromatase Inhibitors; Catalytic Domain; Drug Discovery; Humans; Models, Molecular; Molecular Structure; Structure-Activity Relationship | 2016 |
An overview on Estrogen receptors signaling and its ligands in breast cancer.
Topics: Breast Neoplasms; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Female; Humans; Ligands; Male; Receptors, Estrogen | 2022 |
Aromatase inhibitors: clinical pharmacology and therapeutic implications in breast cancer.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Letrozole; Nitriles; Triazoles | 1992 |
Postmenopausal estrogen synthesis and metabolism: alterations caused by aromatase inhibitors used for the treatment of breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Fadrozole; Female; Humans; Imidazoles; Menopause; Nitriles | 1990 |
Recent progress in development of aromatase inhibitors.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Fadrozole; Humans; Imidazoles; Nitriles | 1990 |
Clinical development of aromatase inhibitors for the treatment of breast and prostate cancer.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Estrogen Antagonists; Fadrozole; Humans; Imidazoles; Nitriles | 1990 |
Aromatase inhibitors in the treatment of advanced breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Imidazoles; Neoplasms, Hormone-Dependent; Nitriles | 1989 |
Clinical use of aromatase inhibitors in the treatment of breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Estrogen Antagonists; Estrogens; Female; Humans | 1988 |
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Aminoglutethimide; Androgens; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogens; Female; Humans; Mammary Neoplasms, Experimental; Metabolic Clearance Rate; Middle Aged; Rats; Tamoxifen | 1986 |
Enzymatic control of estrogen production in human breast cancer: relative significance of aromatase versus sulfatase pathways.
Topics: 17-Hydroxysteroid Dehydrogenases; Adrenalectomy; Aminoglutethimide; Androstenedione; Animals; Aromatase; Breast Neoplasms; Estradiol; Estrogens; Estrone; Female; Humans; Hydrocortisone; Mammary Neoplasms, Experimental; Neoplasms, Hormone-Dependent; Rats; Sulfatases; Testolactone | 1986 |
Aromatase, its inhibitors and their use in breast cancer treatment.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Half-Life; Humans; Neoplasms, Hormone-Dependent; Pargyline | 1993 |
Experience with aromatase inhibitors in the treatment of advanced breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Forecasting; Humans | 1993 |
Use of aromatase inhibitors in postmenopausal women with advanced breast cancer.
Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Enzyme Inhibitors; Estrogen Antagonists; Female; Humans; Letrozole; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Tamoxifen; Triazoles | 1997 |
New aromatase inhibitors for the treatment of advanced breast cancer in postmenopausal women.
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Megestrol Acetate; Nitriles; Postmenopause; Triazoles | 1999 |
[Aromatase inhibitors].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors; Estrogen Antagonists; Estrone; Female; Humans; Letrozole; Nitriles; Triazoles | 1999 |
Use of aromatase inhibitors in breast carcinoma.
Topics: Adult; Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Estrogens; Female; Humans; Letrozole; Middle Aged; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Nitriles; Postmenopause; Premenopause; Tamoxifen; Triazoles | 1999 |
[Preclinical evaluation of aromatase inhibitors antitumor activity].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Animals; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Drug Evaluation, Preclinical; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Models, Animal; Nitriles; Rats; Structure-Activity Relationship; Triazoles | 2000 |
[Aromatase inhibitors: pharmacological aspects].
Topics: Aminoglutethimide; Anastrozole; Androstadienes; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles | 2000 |
Use of aromatase inhibitors in children with short stature.
Topics: Adult; Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Body Height; Child; Estrogens; Female; Growth Disorders; Humans; Letrozole; Male; Musculoskeletal System; Nitriles; Triazoles | 2004 |
Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis.
Topics: Adult; Aged; Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Fadrozole; Female; Humans; Letrozole; Middle Aged; Neoplasm Staging; Neoplasms, Hormone-Dependent; Nitriles; Odds Ratio; Randomized Controlled Trials as Topic; Survival Analysis; Triazoles | 2006 |
Aromatase inhibitors: past, present and future in breast cancer therapy.
Topics: Aminoglutethimide; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Fadrozole; Female; Humans; Letrozole; Nitriles; Triazoles | 2008 |
6 trial(s) available for aminoglutethimide and formestane
| Article | Year |
|---|---|
Influence of aminoglutethimide on plasma oestrogen levels in breast cancer patients on 4-hydroxyandrostenedione treatment.
Topics: Adult; Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged; Pilot Projects | 1992 |
Primary systemic therapy for operable breast cancer.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Buserelin; Combined Modality Therapy; Female; Goserelin; Humans; Lymphatic Metastasis; Middle Aged; Ovariectomy; Tamoxifen | 1991 |
Aromatase in breast cancer and the role of aminoglutethimide and other aromatase inhibitors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Adult; Aged; Aminoglutethimide; Androgens; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Estrogens; Female; Humans; Mammary Neoplasms, Experimental; Metabolic Clearance Rate; Middle Aged; Rats; Tamoxifen | 1986 |
Aromatase inhibition with 4-OHAndrostenedione after prior aromatase inhibition with aminoglutethimide in women with advanced breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Antineoplastic Agents; Aromatase Inhibitors; Breast Neoplasms; Disease-Free Survival; Female; Humans; Middle Aged; Neoplasm Staging; Ovariectomy; Postmenopause | 1995 |
Treatment with formestane alone and in combination with aminoglutethimide in heavily pretreated breast cancer patients: clinical and endocrine effects.
Topics: Adult; Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; Middle Aged | 1996 |
Primary systemic therapy for operable breast cancer--10-year survival data after chemotherapy and hormone therapy.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Axilla; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Goserelin; Humans; Hydrocortisone; Lymphatic Metastasis; Middle Aged; Neoplasms, Hormone-Dependent; Ovariectomy; Prednisone; Preoperative Care; Tamoxifen; Treatment Outcome; Vincristine | 1997 |
34 other study(ies) available for aminoglutethimide and formestane
| Article | Year |
|---|---|
Synthesis and evaluation of 4-(substituted thio)-4-androstene-3,17-dione derivatives as potential aromatase inhibitors.
Topics: Androstenedione; Aromatase Inhibitors; Enzyme Inhibitors; Humans; Kinetics; Structure-Activity Relationship | 1986 |
Aromatase inhibitors. Synthesis and biological activity of androstenedione derivatives.
Topics: Androstenedione; Animals; Aromatase Inhibitors; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Ovary; Oxidoreductases; Placenta; Rats; Structure-Activity Relationship | 1985 |
An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors.
Topics: Androstenedione; Antineoplastic Agents, Hormonal; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Drug Design; Female; Humans; Models, Molecular; Placenta; Pregnancy; Structure-Activity Relationship | 2009 |
Disruption of ovarian development in alligator embryos treated with an aromatase inhibitor.
Topics: Alligators and Crocodiles; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Cyproterone; Cyproterone Acetate; Estradiol; Fadrozole; Female; Imidazoles; Male; Nitriles; Ovary; Tamoxifen; Testis | 1992 |
Endocrine and clinical aspects of new compounds for treatment of hormone-related cancer in gynecology.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Neoplasms, Hormone-Dependent; Tamoxifen | 1990 |
Stable expression of human aromatase complementary DNA in mammalian cells: a useful system for aromatase inhibitor screening.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase; Aromatase Inhibitors; Base Sequence; Blotting, Southern; Cricetinae; Cricetulus; DNA; Female; Gene Expression; Humans; Kinetics; Molecular Sequence Data; Ovary; Placenta; Plasmids; Polymerase Chain Reaction; Pregnancy; Transfection; Tumor Cells, Cultured | 1990 |
Novel irreversible aromatase inhibitors.
Topics: Aminoglutethimide; Androstadienes; Androstenedione; Animals; Aromatase Inhibitors; Female; Gonadotropins, Equine; Humans; In Vitro Techniques; Kinetics; Microsomes; Ovary; Pargyline; Placenta; Rats; Rats, Inbred Strains | 1990 |
An in vitro method to determine the selective inhibition of estrogen biosynthesis by aromatase inhibitors.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Cricetinae; Estrogen Antagonists; Estrogens; Estrus; Fadrozole; Female; Imidazoles; Kinetics; Luteinizing Hormone; Mesocricetus; Nitriles; Ovary; Progesterone; Testolactone; Testosterone | 1989 |
Response to endocrine manipulation and oestrogen receptor concentration in large operable primary breast cancer.
Topics: Aminoglutethimide; Androstenedione; Breast Neoplasms; Buserelin; Female; Goserelin; Humans; Menopause; Receptors, Estrogen; Tamoxifen | 1989 |
Formation of 4-oestrene-3,17-dione (19-norandrostenedione) by porcine granulosa cells in vitro is inhibited by the aromatase inhibitor 4-hydroxyandrostenedione and the cytochrome P-450 inhibitors aminoglutethimide phosphate and ketoconazole.
Topics: Aminoglutethimide; Androstenedione; Animals; Cells, Cultured; Female; Granulosa Cells; Ketoconazole; Swine | 1989 |
Structure-activity relationships of the inhibition of human placental aromatase by imidazole drugs including ketoconazole.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Humans; Imidazoles; Ketoconazole; Microsomes; Placenta; Structure-Activity Relationship | 1988 |
Mammary steroidogenesis: therapeutic implications.
Topics: 17-Hydroxysteroid Dehydrogenases; Adipose Tissue; Aminoglutethimide; Androstenedione; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrogens; Female; Humans; In Vitro Techniques | 1987 |
Aromatase inhibitors and the treatment of breast cancer.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Estradiol; Female; Humans; Kinetics; Luteinizing Hormone; Macaca mulatta; Mammary Neoplasms, Experimental; Menopause; Middle Aged; Neoplasms, Hormone-Dependent; Ovary; Rats; Tamoxifen | 1986 |
Response of nitrosomethylurea-induced rat mammary tumor to endocrine therapy and comparison with clinical response.
Topics: Aminoglutethimide; Androstenedione; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Danazol; Dihydrotestosterone; Female; Humans; Mammary Neoplasms, Experimental; Menopause; Methylnitrosourea; Ovariectomy; Rats; Tamoxifen | 1986 |
Steroid modulation of Mullerian duct regression in the chick embryo.
Topics: Aminoglutethimide; Androstenedione; Animals; Anti-Mullerian Hormone; Chick Embryo; Drug Interactions; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Growth Inhibitors; Male; Mullerian Ducts; Norethindrone; Pyrrolidines; Tamoxifen; Testicular Hormones; Thiophenes | 1985 |
Effects of aromatase inhibitors, aminoglutethimide, and 4-hydroxyandrostenedione on cyclic rats and rats with 7,12-dimethylbenz(a)anthracene-induced mammary tumors.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Estradiol; Estrus; Female; Luteinizing Hormone; Mammary Neoplasms, Experimental; Oxidoreductases; Pregnancy; Rats; Rats, Inbred Strains | 1985 |
Comparative studies of aromatase inhibitors in relation to the significance of estrogen synthesis in human mammary tumors.
Topics: Aminoglutethimide; Androgens; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Cyanoketone; Dehydroepiandrosterone; Estrogens; Female; Humans; Kinetics; Oxidoreductases; Receptors, Estrogen | 1982 |
Biological significance of aromatase activity in human breast tumors.
Topics: Aminoglutethimide; Androstenedione; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Estrone; Female; Humans; Oxidoreductases; Receptors, Estrogen; Receptors, Progesterone; Testolactone | 1983 |
Overview of recent development of aromatase inhibitors.
Topics: Aminoglutethimide; Androstatrienes; Androstenedione; Animals; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; In Vitro Techniques; Macaca mulatta; Male; Oxidoreductases; Pregnancy; Rats | 1982 |
Comparative studies of aromatase inhibitors in cultured human breast cancer cells.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Cell Line; Dihydrotestosterone; Estradiol; Female; Humans; Oxidoreductases; Pargyline; Receptors, Estrogen; Receptors, Progesterone; Testolactone; Testosterone | 1982 |
Inhibition of androgen aromatization in human breast cancer.
Topics: Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Carbon Radioisotopes; Estradiol; Estrone; Female; Humans; Kinetics; Microsomes; Oxidoreductases; Placenta; Pregnancy | 1980 |
Chemopreventive effects of the aromatase inhibitors vorozole (R-83842) and 4-hydroxyandrostenedione in the methylnitrosourea (MNU)-induced mammary tumor model in Sprague-Dawley rats.
Topics: Adenocarcinoma; Aminoglutethimide; Androstenedione; Animals; Anticarcinogenic Agents; Aromatase Inhibitors; Drug Screening Assays, Antitumor; Estrus; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Triazoles | 1994 |
Mutagenesis study at a postulated hydrophobic region near the active site of aromatase cytochrome P450.
Topics: Amino Acid Sequence; Aminoglutethimide; Androstenedione; Aromatase; Aromatase Inhibitors; Binding Sites; Computer Simulation; DNA Mutational Analysis; Dose-Response Relationship, Drug; Fadrozole; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Effect of aromatase inhibitors on estrogen 2-hydroxylase in rat liver.
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Binding, Competitive; Cytochrome P-450 CYP1A1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Estradiol; Estrone; Fadrozole; Female; Ketoconazole; Microsomes, Liver; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases; Substrate Specificity | 1994 |
Combined treatment with 4-hydroxyandrostenedione and aminoglutethimide: effects on aromatase inhibition and oestrogen suppression.
Topics: Adult; Aged; Aminoglutethimide; Androstenedione; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Carbon Radioisotopes; Estrogens; Female; Humans; Middle Aged; Postmenopause; Radioisotope Dilution Technique | 1994 |
Growth suppression of MCF-7 human breast cancer cells by aromatase inhibitors: a new system for aromatase inhibitor screening.
Topics: Aminoglutethimide; Androstenedione; Androstenols; Antineoplastic Agents; Aromatase; Aromatase Inhibitors; Breast Neoplasms; Cell Division; Dose-Response Relationship, Drug; Fadrozole; Female; Humans; Kinetics; Tumor Cells, Cultured | 1993 |
A sensitive assay for measurement of plasma estrone sulphate in patients on treatment with aromatase inhibitors.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Enzyme Inhibitors; Estrone; Female; Humans; Hydrolysis; Menopause; Radioimmunoassay; Sensitivity and Specificity | 1995 |
The preclinical pharmacology of "Arimidex" (anastrozole; ZD1033)--a potent, selective aromatase inhibitor.
Topics: Adrenal Glands; Aminoglutethimide; Anastrozole; Androstenedione; Animals; Aromatase Inhibitors; Cortodoxone; Enzyme Inhibitors; Fadrozole; Female; Hormones; Humans; Macaca nemestrina; Male; Metyrapone; Nitriles; Organ Size; Potassium; Prostate; Rats; Rats, Wistar; Seminal Vesicles; Sodium; Triazoles; Uterus | 1996 |
Effects of treatment with megestrol acetate, aminoglutethimide, or formestane on insulin-like growth factor (IGF) I and II, IGF-binding proteins (IGFBPs), and IGFBP-3 protease status in patients with advanced breast cancer.
Topics: Aged; Aged, 80 and over; Aminoglutethimide; Androstenedione; Aromatase Inhibitors; Blotting, Western; Breast Neoplasms; Endopeptidases; Female; Humans; Insulin-Like Growth Factor Binding Proteins; Megestrol Acetate; Middle Aged; Radioimmunoassay; Somatomedins | 1996 |
Aromatase inhibitors come of age.
Topics: Aminoglutethimide; Anastrozole; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials, Phase III as Topic; Female; Humans; Letrozole; Nitriles; Triazoles | 1997 |
Aromatase inhibitors for breast cancer--further progress.
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Clinical Trials as Topic; Female; Humans; Megestrol Acetate | 1997 |
Influence of aromatase inhibitors on plasma total homocysteine in postmenopausal breast cancer patients.
Topics: Aminoglutethimide; Androstadienes; Androstenedione; Aromatase Inhibitors; Breast Neoplasms; Creatinine; Enzyme Inhibitors; Estrogen Antagonists; Homocysteine; Humans; Postmenopause; Vitamins | 1999 |
[Aromatase inhibitors].
Topics: Aminoglutethimide; Androstenedione; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Enzyme Inhibitors; Tamoxifen | 2000 |
The effects of aromatase inhibitors and selective estrogen receptor modulators on eye development in the zebrafish (Danio rerio).
Topics: Aminoglutethimide; Androstenedione; Animals; Aromatase Inhibitors; Clomiphene; Embryo, Nonmammalian; Embryonic Development; Estrogens; Eye; Retina; Selective Estrogen Receptor Modulators; Tamoxifen; Zebrafish | 2007 |