Compounds > aminoacetonitrile
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aminoacetonitrile and sl 327

aminoacetonitrile has been researched along with sl 327 in 82 studies

Research

Studies (82)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's39 (47.56)29.6817
2010's39 (47.56)24.3611
2020's4 (4.88)2.80

Authors

AuthorsStudies
Grant, S; Vrana, JA1
Feuerstein, GZ; Friedman, SM; Trzaskos, JM; Venkatachalam, S; Wang, H; Wang, X; Xu, L1
Czernik, AJ; Greengard, P; Jovanovic, JN; Obata, K; Yamagata, Y1
Berkeley, JL; Decker, MJ; Levey, AI1
Bachtell, RK; Ryabinin, AE; Tsivkovskaia, NO1
Chan, PH; Feuerstein, GZ; Rozanski, DJ; Sugawara, T; Trzaskos, JM; Wang, H; Wang, X; Xu, L1
Chen, G; Du, J; Einat, H; Gould, TD; Li, J; Manji, HK; Yuan, P; Zhang, L1
Blake, BL; Breese, GR; Knapp, DJ; Papadeas, ST1
Bonzo, J; Chen, S; Nguyen, N; Operaña, T; Tukey, RH1
Davis, JA; Gould, TJ; Lewis, MC1
Forlani, G; Parolaro, D; Rubino, T; Viganò, D; Zippel, R1
Carr, KD; Haberny, SL1
Miwa, N; Storm, DR1
Caboche, J; Kaczmarek, L; Radwanska, K1
Caboche, J; Kaczmarek, L; Radwanska, K; Trzaskos, J; Valjent, E1
Barlow, EH; Bhatia, P; Bitner, RS; Brioni, JD; Decker, MW; Martino, B; Moreland, RB; Nikkel, AL; Otte, S; Stewart, AO1
McGinty, JF; Shi, X1
Bertran-Gonzalez, J; Corbillé, AG; Girault, JA; Hervé, D; Valjent, E1
Castellano, C; Cestari, V; Costanzi, M; Rossi-Arnaud, C1
Corvol, JC; Girault, JA; Hervé, D; Trzaskos, JM; Valjent, E1
Hakim, S; Lombroso, PJ; Mills, E; Moran, TD; Olausson, P; Paul, S; Ruchkina, I; Salter, MW; Taylor, JR; Tronson, N; Venkitaramani, DV1
Braida, D; Castiglioni, C; Guidali, C; Limonta, V; Parolaro, D; Realini, N; Rubino, T; Sala, M; Viganò, D1
Almela, P; Laorden, ML; Milanés, MV1
Díaz, MF; Gutstein, HB; Moulédous, L1
Anderson, DJ; Bitner, RS; Briggs, CA; Buccafusco, J; Bunnelle, WH; Curzon, P; Decker, MW; Frost, JM; Gopalakrishnan, M; Gronlien, JH; Gubbins, E; Li, J; Malysz, J; Markosyan, S; Marsh, K; Meyer, MD; Nikkel, AL; Radek, RJ; Robb, HM; Sullivan, JP; Timmermann, D1
Gould, TJ; Raybuck, JD1
Almela, P; Laorden, M; Milanés, M1
Castells, MT; Laorden, ML; Milanés, MV; Núñez, C1
Lin, CH; Wu, TH1
Fernandez, SM; Frick, KM; Gresack, JE; Harburger, LL; Lewis, MC; Orr, PT; Pechenino, AS; Schafe, GE1
Carr, KD; Chau, LS; de Vaca, SC; Dela Cruz, J; Pan, Y; Sun, Y1
Blake, BL; Breese, GR; Halloran, C; McCown, TJ; Papadeas, ST1
Besheer, J; Faccidomo, S; Hodge, CW; Stanford, PC1
Choi, WC; Jang, CG; Jin, CH; Kim, HC; Kim, MS; Koo, KH; Li, Z; Nabeshima, T; Park, JB; Park, SJ; Shin, EJ; Yamada, K; Yoon, HJ1
Almela, P; Atucha, NM; Laorden, ML; Milanés, MV1
Cenci, MA; Lindgren, HS; Ohlin, KE1
Angelatou, F; Matsokis, N; Sarantis, K1
Bryant, CD; Eitan, S; Evans, CJ; Hodgson, SR; Hofford, RS; Roberts, KW1
Esteban, S; García-Sevilla, JA; Ramos-Miguel, A1
Alcacer, C; Davis, S; Hars, B; Languille, S; Laroche, S; Richer, P1
Monsey, MS; Park, KW; Ping, J; Ploski, JE; Schafe, GE1
Alkam, T; Furukawa-Hibi, Y; Mizoguchi, H; Nabeshima, T; Nitta, A; Niwa, M; Yamada, K1
Bureau, G; Carrier, M; Cyr, M; Lebel, M1
Kayama, T; Kitanaka, C; Matsuda, K; Narita, Y; Sakurada, K; Sato, A; Shibui, S; Sunayama, J; Suzuki, K; Tachibana, K; Tomiyama, A1
Cunningham, CL; Franken, FH; Groblewski, PA1
Giordano, TP; Kosofsky, BE; Rajadhyaksha, AM; Satpute, SS; Sinnegger-Brauns, MJ; Striessnig, J; Tropea, TF1
Britt, JP; Ding, Y; Kang, UJ; Lim, SA; McGehee, DS; Won, L1
Acquas, E; Longoni, R; Spina, L; Vinci, S1
Brandl, MB; Chang, J; Cui, K; Jin, G; Li, F; Mao, Y; Nie, F; Rodriguez, A; Wang, L; Wong, ST; Xue, Z; Zhao, H1
Almela, P; Atucha, NM; Laorden, ML; Martínez-Laorden, E; Milanés, MV1
Kayama, T; Kitanaka, C; Matsuda, K; Sato, A; Seino, S; Sunayama, J; Suzuki, K; Tachibana, K; Tomiyama, A; Watanabe, E1
Houpt, TA; Kwon, B1
Casadesus, G; Castellani, RJ; Klann, E; Petersen, RB; Singh, A; Smith, MA; Snape, M; Stone, JG; Wang, X; Zhu, X1
Almela, P; Hurle, MA; Laorden, ML; Martínez-Laorden, E; Milanés, MV1
Liu, D; Wang, S; Xu, T; Yu, L; Yu, SY; Zhan, R; Zhang, L1
Hascher, A; Henklein, P; Katenkamp, K; Kaufmann, R; Mussbach, F; Settmacher, U; Westermann, M1
Halleskog, C; Schulte, G1
Calza, A; Ciccarelli, A; Concas, A; Giustetto, M; Grasso, F; Santoru, F; Sassoè-Pognetto, M1
Aparicio, S; Esteban, S; Garau, C; Miralles, A; Ramis, M; Sarubbo, F; Sola, J1
Bertran-Gonzalez, J; Bonito-Oliva, A; Fisone, G; Girault, JA; Pallottino, S; Valjent, E1
Cao, WY; Dai, RP; Duan, J; Hu, ZL; Li, CQ; Li, F; Luo, XG; Luo, YW; Wang, XQ; Xu, Y; Zhang, JY; Zhong, XL1
Antoine, MW; Arezzo, JC; Hébert, JM; Hübner, CA1
Itzhak, Y; Liddie, S1
Chernigovskaya, EV; Dorofeeva, NA; Glazova, MV; Hudik, KA; Kirillova, OD; Korotkov, AA; Nikitina, LS1
Agoglia, AE; Hodge, CW; Holstein, SE; Psilos, KE; Reid, GT; Sharko, AC1
Endo, S; Kazama, T; Kobayashi, Y; Ohta, H; Pagès, G; Pouysségur, J; Satoh, Y; Takaenoki, Y; Takamatsu, I; Yufune, S1
Faccidomo, S; Galunas, C; Hodge, CW; Salling, MC1
Akai, R; Endo, S; Kazama, T; Kobayashi, Y; Satoh, Y; Yoshinaga, Y; Yufune, S1
Chen, SM; Chen, XM; Geng, D; Li, CF; Liu, Q; Mu, RH; Wang, SS; Yi, LT1
Acquas, E; Collu, M; Longoni, R; Peana, AT; Porru, S; Rosas, M; Spina, L1
Berrocoso, E; Borges, G; Mico, JA; Miguelez, C; Neto, F; Ugedo, L1
Chen, S; Wang, W; Zhao, L; Zhou, J1
Choi, YH; Kim, EY; Nam, TJ; Oh, JH1
Dong, C; Hashimoto, K; Ma, M; Qu, Y; Ren, Q; Yang, C; Zhang, JC1
Chernigovskaya, EV; Dorofeeva, NA; Glazova, MV; Grigorieva, YS; Lavrova, EA; Nasluzova, EV; Nikitina, LS1
Biala, G; Budzynska, B; Kruk-Slomka, M; Michalak, A; Pekala, K1
Eun, PH; Gonzales, EL; Kang, RJ; Kim, DG; Kim, JW; Kim, Y; Ko, MJ; Oh, HA; Seung, H; Shin, CY1
Kim, HJ; Lee, HR; Lee, J1
Angara, K; Bilinovich, SM; Li, KX; Nguyen, JT; Pai, EL; Paul, A; Rubenstein, JL; Stafford, AM; Vogt, D1
Berardinelli, A; Budzyńska, B; Michalak, A; Rusinek, J; Wnorowski, A; Zinato, S1
Anantha Reddy, P; Brieaddy, L; Carroll, FI; Deschamps, J; Fix, S; Imler, GH; Lewin, AH; Mascarella, SW; McElhinny, CJ; Seltzman, HH1
Araki, K; Endo, S; Fujitani, K; Kimura, A; Kurioka, T; Mogi, S; Satoh, Y; Shiotani, A; Yamashita, T1

Other Studies

82 other study(ies) available for aminoacetonitrile and sl 327

ArticleYear
Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade.
    Blood, 2001, Apr-01, Volume: 97, Issue:7

    Topics: Acetylcysteine; Amanitins; Aminoacetonitrile; Apoptosis; Benzoquinones; Bryostatins; Butadienes; Curcumin; Cysteine Endopeptidases; Dactinomycin; Diterpenes; Drug Synergism; Enzyme Activation; Flavonoids; Humans; Imidazoles; Indoles; JNK Mitogen-Activated Protein Kinases; Lactams, Macrocyclic; Lactones; Macrolides; Maleimides; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Neoplasm Proteins; Nitriles; Nucleic Acid Synthesis Inhibitors; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Synthesis Inhibitors; Proto-Oncogene Proteins c-raf; Pyridines; Quinones; Terpenes; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Type C Phospholipases; U937 Cells; Ubiquitins

2001
Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral ischemia in mice.
    Biochemical and biophysical research communications, 2001, Sep-07, Volume: 286, Issue:5

    Topics: Aminoacetonitrile; Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Interleukin-1; Male; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase Kinases; Protease Inhibitors; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha

2001
Bidirectional changes in synapsin I phosphorylation at MAP kinase-dependent sites by acute neuronal excitation in vivo.
    Journal of neurochemistry, 2002, Volume: 80, Issue:5

    Topics: Aminoacetonitrile; Animals; Binding Sites; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Electroshock; Enzyme Activation; Enzyme Inhibitors; Hippocampus; Immunoblotting; Male; Mitogen-Activated Protein Kinases; Neurons; Parietal Lobe; Phosphorylation; Protease Inhibitors; Rats; Rats, Wistar; Seizures; Synapsins

2002
The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures.
    Journal of neurochemistry, 2002, Volume: 82, Issue:1

    Topics: Aminoacetonitrile; Animals; Blotting, Western; Cell Death; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mossy Fibers, Hippocampal; Neurons; Pilocarpine; Protease Inhibitors; Receptors, Muscarinic; Recurrence; Seizures; Status Epilepticus; Survival Rate

2002
Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 302, Issue:2

    Topics: Aminoacetonitrile; Animals; Brain; Chlordiazepoxide; Dopamine; Ethanol; Gene Expression Regulation; Genes, fos; Haloperidol; Male; Mice; Mice, Inbred C57BL; Morphine; Norepinephrine; Pregnanolone; Protease Inhibitors; Signal Transduction; Tyrosine 3-Monooxygenase; Yohimbine

2002
Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis.
    The Journal of pharmacology and experimental therapeutics, 2003, Volume: 304, Issue:1

    Topics: Aminoacetonitrile; Animals; Apoptosis; Blotting, Western; Brain Infarction; Brain Ischemia; Caspase 3; Caspases; Cytochrome c Group; DNA Fragmentation; Enzyme Inhibitors; Infarction, Middle Cerebral Artery; Male; MAP Kinase Kinase 1; Mice; Mice, Inbred C57BL; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Neuroprotective Agents; Phosphorylation; Postural Balance; Protease Inhibitors; Protein Serine-Threonine Kinases; Reperfusion Injury

2003
The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2003, Aug-13, Volume: 23, Issue:19

    Topics: Affect; Aminoacetonitrile; Animals; Antidepressive Agents; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Central Nervous System; Enzyme Inhibitors; Frontal Lobe; Hippocampus; Lithium Carbonate; Locomotion; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitogen-Activated Protein Kinases; Mutation; Protease Inhibitors; Rats; Swimming; Valproic Acid

2003
Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2004, Jun-30, Volume: 24, Issue:26

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aminoacetonitrile; Animals; Animals, Newborn; Benzazepines; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Dopamine Agonists; Dopamine Antagonists; Enzyme Inhibitors; Female; Ketanserin; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Nucleus Accumbens; Oxidopamine; Phosphorylation; Prefrontal Cortex; Protease Inhibitors; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Serotonin 5-HT2 Receptor Antagonists

2004
ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation.
    The Journal of biological chemistry, 2005, Feb-11, Volume: 280, Issue:6

    Topics: Aminoacetonitrile; Apoptosis; Blotting, Western; Butadienes; Cell Line; Cell Line, Tumor; Cell Nucleus; Centrifugation, Density Gradient; Cytochrome P-450 CYP1A1; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Immunoprecipitation; Ligands; Luciferases; MAP Kinase Kinase 1; Models, Chemical; Nitriles; Phosphorylation; Plasmids; Polychlorinated Dibenzodioxins; Polymerase Chain Reaction; Protease Inhibitors; Protein Binding; Protein Structure, Tertiary; Proteins; Receptors, Aryl Hydrocarbon; RNA; Signal Transduction; Sucrose; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Ubiquitin

2005
Inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase disrupts latent inhibition of cued fear conditioning in C57BL/6 mice.
    Behavioral neuroscience, 2004, Volume: 118, Issue:6

    Topics: Acoustic Stimulation; Aminoacetonitrile; Animals; Conditioning, Psychological; Cues; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Extracellular Signal-Regulated MAP Kinases; Fear; Inhibition, Psychological; Male; Mice; Mice, Inbred C57BL; Protease Inhibitors

2004
Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects.
    Journal of neurochemistry, 2005, Volume: 93, Issue:4

    Topics: Aminoacetonitrile; Analgesics; Animals; Autoradiography; Behavior, Animal; Blotting, Western; Brain; Cyclohexanols; Diagnostic Imaging; Dronabinol; Drug Administration Schedule; Drug Tolerance; Extracellular Signal-Regulated MAP Kinases; Guanosine 5'-O-(3-Thiotriphosphate); Mice; Mice, Knockout; Motor Activity; Protease Inhibitors; Protein Binding; ras-GRF1; Receptor, Cannabinoid, CB1; Signal Transduction; Sulfur Isotopes; Tritium

2005
Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor
    Neuroscience, 2005, Volume: 132, Issue:4

    Topics: Activating Transcription Factor 2; Aminoacetonitrile; Animals; Benzazepines; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP Response Element-Binding Protein; Diet; Dizocilpine Maleate; Dopamine Agonists; Excitatory Amino Acid Antagonists; Injections, Intraventricular; Male; Mitogen-Activated Protein Kinase 1; Nucleus Accumbens; Phosphorylation; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transcription Factors

2005
Odorant-induced activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in the olfactory bulb promotes survival of newly formed granule cells.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jun-01, Volume: 25, Issue:22

    Topics: Aminoacetonitrile; Animals; Bromodeoxyuridine; Cell Nucleus; Cell Survival; Cells, Cultured; Dendrites; Enzyme Activation; Immunohistochemistry; Indicators and Reagents; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Neurons; Odorants; Olfactory Bulb

2005
Extracellular signal-regulated kinases (ERKs) modulate cocaine-induced gene expression in the mouse amygdala.
    The European journal of neuroscience, 2005, Volume: 22, Issue:4

    Topics: Aminoacetonitrile; Amygdala; Animals; Cocaine; DNA-Binding Proteins; Dopamine Uptake Inhibitors; Drug Administration Schedule; Drug Interactions; Early Growth Response Protein 1; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Immediate-Early Proteins; Immunohistochemistry; Mice; Protease Inhibitors; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Time Factors; Transcription Factors

2005
Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway.
    Neuroscience, 2006, Volume: 137, Issue:1

    Topics: Aminoacetonitrile; Animals; Blotting, Western; Cocaine; Cocaine-Related Disorders; Dopamine Uptake Inhibitors; Electrophoretic Mobility Shift Assay; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Immunohistochemistry; Male; Mice; Neostriatum; Time Factors; Transcription Factor AP-1

2006
Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation.
    Neuropharmacology, 2006, Volume: 50, Issue:5

    Topics: Aminoacetonitrile; Animals; Benzamides; Benzimidazoles; Cell Count; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Genes, fos; Immunohistochemistry; Male; Paraventricular Hypothalamic Nucleus; Phosphorylation; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D4; Signal Transduction; Time Factors

2006
Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum.
    Neuroscience, 2006, Volume: 138, Issue:4

    Topics: Aminoacetonitrile; Amphetamine; Amphetamine-Related Disorders; Animals; Butadienes; Corpus Striatum; Disease Models, Animal; Dynorphins; Enkephalins; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Male; MAP Kinase Signaling System; Motor Activity; Neuropeptides; Nitriles; Phosphorylation; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Up-Regulation

2006
Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Feb-21, Volume: 103, Issue:8

    Topics: Aminoacetonitrile; Animals; Cocaine; Cocaine-Related Disorders; Conditioning, Classical; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Motor Activity; Protease Inhibitors; Protein Biosynthesis

2006
A role for ERK2 in reconsolidation of fear memories in mice.
    Neurobiology of learning and memory, 2006, Volume: 86, Issue:2

    Topics: Aminoacetonitrile; Analysis of Variance; Animals; Association Learning; Conditioning, Classical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fear; Freezing Reaction, Cataleptic; Male; MAP Kinase Kinase Kinases; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3

2006
Role of the ERK pathway in psychostimulant-induced locomotor sensitization.
    BMC neuroscience, 2006, Mar-02, Volume: 7

    Topics: Aminoacetonitrile; Animals; Behavior, Animal; Brain; Cocaine; Conditioning, Psychological; Dextroamphetamine; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Motor Activity; Phosphorylation; Psychotropic Drugs

2006
The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala.
    Biological psychiatry, 2007, May-01, Volume: 61, Issue:9

    Topics: Acoustic Stimulation; Aminoacetonitrile; Amygdala; Animals; Behavior, Animal; Cells, Cultured; Conditioning, Classical; Cycloheximide; Electric Stimulation; Enzyme Inhibitors; Fear; Female; Immunohistochemistry; In Vitro Techniques; Long-Term Potentiation; Memory; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neostriatum; Patch-Clamp Techniques; Point Mutation; Pregnancy; Protein Synthesis Inhibitors; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Translocation, Genetic

2007
Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:9

    Topics: Adenosine Triphosphate; Aminoacetonitrile; Analysis of Variance; Animals; Behavior, Animal; Brain; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Male; Maze Learning; Motor Activity; Piperidines; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley

2007
Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal.
    British journal of pharmacology, 2007, Volume: 151, Issue:6

    Topics: Aminoacetonitrile; Animals; Blotting, Western; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Genes, fos; Heart Ventricles; Immunohistochemistry; Male; MAP Kinase Signaling System; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance Withdrawal Syndrome

2007
Extracellular signal-regulated kinase (ERK) inhibition does not prevent the development or expression of tolerance to and dependence on morphine in the mouse.
    Pharmacology, biochemistry, and behavior, 2007, Volume: 88, Issue:1

    Topics: Aminoacetonitrile; Animals; Blotting, Western; Dose-Response Relationship, Drug; Drug Tolerance; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine Dependence; Naloxone; Narcotic Antagonists; Neuronal Plasticity; Pain Measurement; Reaction Time; Substance Withdrawal Syndrome

2007
Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007, Sep-26, Volume: 27, Issue:39

    Topics: alpha7 Nicotinic Acetylcholine Receptor; Aminoacetonitrile; Animals; Central Nervous System Agents; Cognition; Cyclic AMP Response Element-Binding Protein; Extracellular Signal-Regulated MAP Kinases; Humans; Learning; Macaca mulatta; Male; Mental Processes; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Pyridazines; Pyrroles; Rats; Receptors, Nicotinic; Signal Transduction; Treatment Outcome; Xenopus

2007
Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine.
    Behavioral neuroscience, 2007, Volume: 121, Issue:5

    Topics: Aminoacetonitrile; Animals; Conditioning, Psychological; Enzyme Inhibitors; Fear; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nicotine; Nicotinic Agonists

2007
The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.
    British journal of pharmacology, 2008, Volume: 155, Issue:1

    Topics: Aminoacetonitrile; Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Implants; Isoquinolines; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morphine; Morphine Dependence; Myocardium; Naloxone; Naphthalenes; Narcotic Antagonists; Norepinephrine; Phosphorylation; Protein Kinase C-delta; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Serine; Substance Withdrawal Syndrome; Sulfonamides; Tyrosine 3-Monooxygenase

2008
Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 378, Issue:4

    Topics: Aminoacetonitrile; Animals; Blotting, Western; Brain; Corticotropin-Releasing Hormone; Extracellular Signal-Regulated MAP Kinases; Immunochemistry; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Paraventricular Hypothalamic Nucleus; Protease Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Signal Transduction; Solitary Nucleus; Substance Withdrawal Syndrome; Time Factors

2008
IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions.
    Behavioural brain research, 2008, Nov-21, Volume: 193, Issue:2

    Topics: Aminoacetonitrile; Amygdala; Animals; Behavior, Animal; Blotting, Western; Body Temperature; Enzyme Activation; Hippocampus; Immobility Response, Tonic; Interleukin-6; Male; Microinjections; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Motor Activity; Rats; Rats, Sprague-Dawley; Stress, Psychological; Sulfoxides; Swimming; Tetrazoles

2008
Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008, Aug-27, Volume: 28, Issue:35

    Topics: Aminoacetonitrile; Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Drug Administration Routes; Enzyme Inhibitors; Estradiol; Estrogens; Exploratory Behavior; Extracellular Signal-Regulated MAP Kinases; Female; Hippocampus; Maze Learning; Mice; Mice, Inbred C57BL; Muscimol; Ovariectomy; Receptors, Estrogen; Recognition, Psychology; Time Factors

2008
Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat.
    Psychopharmacology, 2009, Volume: 201, Issue:4

    Topics: Aminoacetonitrile; Animals; Benzazepines; Dextroamphetamine; Food Deprivation; Injections, Intraperitoneal; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase Kinases; Motor Activity; Nucleus Accumbens; Rats; Rats, Sprague-Dawley; Reward; Signal Transduction

2009
Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization.
    The Journal of comparative neurology, 2008, Nov-10, Volume: 511, Issue:2

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aminoacetonitrile; Animals; Dendrites; Dopamine Agonists; Flavonoids; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidopamine; Phosphorylation; Prefrontal Cortex; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Sympatholytics

2008
Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway.
    Psychopharmacology, 2009, Volume: 204, Issue:1

    Topics: Acetonitriles; Alcohol Drinking; Aminoacetonitrile; Animals; Behavior, Animal; Benzothiazoles; Central Nervous System Depressants; Conditioning, Operant; Dose-Response Relationship, Drug; Ethanol; Extracellular Signal-Regulated MAP Kinases; JNK Mitogen-Activated Protein Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Motor Activity; Reinforcement, Psychology; Self Administration; Sucrose; Sweetening Agents

2009
Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment.
    Journal of neuroscience research, 2009, Volume: 87, Issue:16

    Topics: Acetylcholine; Aminoacetonitrile; Amyloid beta-Peptides; Analysis of Variance; Animals; Autoradiography; Avoidance Learning; Blotting, Western; Brain-Derived Neurotrophic Factor; Choline O-Acetyltransferase; Cognition; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Dicyclomine; Dose-Response Relationship, Drug; Fear; Flavonoids; Hippocampus; Immunoprecipitation; Learning; Mice; Mitogen-Activated Protein Kinase 3; Muscarinic Antagonists; Peptide Fragments; Receptor, Muscarinic M1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2009
Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 330, Issue:3

    Topics: Adaptation, Physiological; Aminoacetonitrile; Analgesics, Opioid; Animals; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Heart; Hemodynamics; Isoquinolines; Male; Mitogen-Activated Protein Kinases; Morphine; Naloxone; Naphthalenes; Narcotic Antagonists; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance Withdrawal Syndrome; Sulfonamides; Tyrosine 3-Monooxygenase; Weight Gain

2009
Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009, Volume: 34, Issue:12

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aminoacetonitrile; Animals; Antiparkinson Agents; Basal Ganglia; Benzazepines; Bromocriptine; Disease Models, Animal; Dopamine Agents; Dopamine D2 Receptor Antagonists; Extracellular Signal-Regulated MAP Kinases; Female; Levodopa; Neovascularization, Pathologic; Oxidopamine; Parkinsonian Disorders; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, Dopamine D2; Salicylamides

2009
Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling.
    Neuroscience, 2009, Nov-10, Volume: 163, Issue:4

    Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Aminoacetonitrile; Animals; Cyclic AMP-Dependent Protein Kinases; Dopamine Agonists; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; N-Methylaspartate; Phosphorylation; Prefrontal Cortex; Rats; Rats, Wistar; Receptors, AMPA; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate

2009
Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal.
    Behavioural pharmacology, 2009, Volume: 20, Issue:7

    Topics: Aminoacetonitrile; Amygdala; Animals; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Male; Maze Learning; Mice; Mice, Inbred C57BL; Morphine; Naloxone; Septum of Brain; Substance Withdrawal Syndrome

2009
The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2010, Volume: 20, Issue:1

    Topics: Aminoacetonitrile; Analysis of Variance; Animals; Apoptosis; Brain Chemistry; Chromatography, High Pressure Liquid; Corpus Striatum; Drug Administration Schedule; Electrochemistry; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fas-Associated Death Domain Protein; Gene Expression Regulation; JNK Mitogen-Activated Protein Kinases; Locomotion; Male; Morphine; Narcotics; Nerve Tissue Proteins; Phosphorylation; Protein Binding; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Signal Transduction; Substance Withdrawal Syndrome; Time Factors

2010
Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis.
    The European journal of neuroscience, 2009, Volume: 30, Issue:10

    Topics: Aging; Aminoacetonitrile; Animals; Animals, Newborn; Avoidance Learning; Brain; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Male; Memory; Phosphorylation; Rats; Signal Transduction; Taste; Time Factors

2009
Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala.
    Journal of neurochemistry, 2010, Volume: 112, Issue:3

    Topics: Aminoacetonitrile; Amygdala; Analysis of Variance; Animals; Biophysics; Conditioning, Classical; CREB-Binding Protein; Dentate Gyrus; Electric Stimulation; Extracellular Signal-Regulated MAP Kinases; Fear; Gene Expression Profiling; Gene Expression Regulation; Long-Term Potentiation; Male; Microdissection; Oligonucleotide Array Sequence Analysis; Protease Inhibitors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors

2010
Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase.
    Behavioural brain research, 2010, Jul-11, Volume: 210, Issue:2

    Topics: Administration, Oral; Aminoacetonitrile; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Enzyme Inhibitors; Exploratory Behavior; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hippocampus; Isoleucine; Leucine; Male; Memory Disorders; Mice; Mice, Inbred ICR; Nitric Oxide Synthase Type II; Oligopeptides; Peptide Fragments; Phosphorylation; Recognition, Psychology; Time Factors

2010
Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning.
    Neurobiology of learning and memory, 2010, Volume: 94, Issue:1

    Topics: Aminoacetonitrile; Animals; Brain; Corpus Striatum; Early Growth Response Protein 1; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Learning; Male; Memory; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Motor Skills; Phosphorylation; Proto-Oncogene Proteins c-fos

2010
Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells.
    Stem cells (Dayton, Ohio), 2010, Volume: 28, Issue:11

    Topics: Aminoacetonitrile; Animals; Butadienes; Cell Differentiation; Cell Line, Tumor; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Glioblastoma; Humans; Imidazoles; Male; Mice; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Neoplastic Stem Cells; Nitriles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Quinolines; Signal Transduction; TOR Serine-Threonine Kinases; Tumor Cells, Cultured

2010
Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice.
    Behavioural brain research, 2011, Mar-01, Volume: 217, Issue:2

    Topics: Aminoacetonitrile; Analysis of Variance; Animals; Behavior, Animal; Central Nervous System Depressants; Conditioning, Operant; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug-Seeking Behavior; Enzyme Inhibitors; Ethanol; Extinction, Psychological; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Male; Mice; Mice, Inbred DBA; Reinforcement, Psychology; Signal Transduction; Time Factors

2011
Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, Dec-15, Volume: 30, Issue:50

    Topics: Aminoacetonitrile; Amphetamine; Animals; Benzazepines; Calcium Channels, L-Type; Central Nervous System Stimulants; Cocaine; Cyclic AMP Response Element-Binding Protein; Drug Interactions; Male; Mice; Mice, Knockout; Motor Activity; Nifedipine; Nucleus Accumbens; Signal Transduction

2010
Enhanced striatal cholinergic neuronal activity mediates L-DOPA-induced dyskinesia in parkinsonian mice.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Jan-11, Volume: 108, Issue:2

    Topics: Adenosine A2 Receptor Antagonists; Aminoacetonitrile; Animals; Aphakia; Choline O-Acetyltransferase; Cholinergic Fibers; Disease Models, Animal; Dopamine; Dyskinesias; Gene Expression Regulation; Homeodomain Proteins; Levodopa; Mice; Mice, Transgenic; Neurons; Parkinson Disease; Phosphorylation; Transcription Factors

2011
The MEK inhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study.
    Psychopharmacology, 2011, Volume: 216, Issue:1

    Topics: Aminoacetonitrile; Animals; Behavior, Animal; Conditioning, Classical; Corpus Striatum; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Lithium Chloride; Male; Mice; Mice, Inbred C57BL; Protein Kinase Inhibitors

2011
The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models.
    Breast cancer research and treatment, 2012, Volume: 131, Issue:2

    Topics: Aminoacetonitrile; Animals; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Female; Humans; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Nude; Mitogen-Activated Protein Kinase Kinases; Neoplasm Invasiveness; Neovascularization, Pathologic; Protein Kinase Inhibitors; Sirolimus; TOR Serine-Threonine Kinases

2012
Naloxone-precipitated morphine withdrawal evokes phosphorylation of heat shock protein 27 in rat heart through extracellular signal-regulated kinase.
    Journal of molecular and cellular cardiology, 2011, Volume: 51, Issue:1

    Topics: Aminoacetonitrile; Animals; Extracellular Signal-Regulated MAP Kinases; Heart; Heart Ventricles; HSP27 Heat-Shock Proteins; Immunoblotting; Morphine; Morphine Dependence; Myocardium; Naloxone; Phosphorylation; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome

2011
MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis.
    Stem cells (Dayton, Ohio), 2011, Volume: 29, Issue:12

    Topics: Aminoacetonitrile; Animals; Dacarbazine; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Imidazoles; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Piperazines; Proto-Oncogene Proteins c-mdm2; RNA Interference; Temozolomide; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Tumor Suppressor Proteins

2011
Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning.
    Neurobiology of learning and memory, 2012, Volume: 97, Issue:1

    Topics: Aminoacetonitrile; Amygdala; Animals; Avoidance Learning; Conditioning, Psychological; Lithium Chloride; Male; Microinjections; Mitogen-Activated Protein Kinases; Phosphorylation; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Taste

2012
Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome.
    Journal of neurochemistry, 2012, Volume: 121, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aminoacetonitrile; Animals; Blotting, Western; Child; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Phosphorylation; Protease Inhibitors; Seizures; Signal Transduction; Young Adult

2012
Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase.
    The Journal of pharmacology and experimental therapeutics, 2012, Volume: 342, Issue:3

    Topics: Adrenergic beta-Antagonists; Adrenocorticotropic Hormone; Aminoacetonitrile; Animals; Catechol O-Methyltransferase; Corticosterone; Extracellular Signal-Regulated MAP Kinases; Heart; Heart Ventricles; HSP27 Heat-Shock Proteins; Hypothalamo-Hypophyseal System; Male; Morphine; Morphine Dependence; Naloxone; Norepinephrine; Phosphorylation; Pituitary-Adrenal System; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Substance Withdrawal Syndrome

2012
Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice.
    Behavioural brain research, 2012, Nov-01, Volume: 235, Issue:1

    Topics: Aminoacetonitrile; Amygdala; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Curcumin; Depression; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Phosphorylation

2012
Proteinase-activated receptor 2 (PAR(2)) in cholangiocarcinoma (CCA) cells: effects on signaling and cellular level.
    Histochemistry and cell biology, 2012, Volume: 138, Issue:6

    Topics: Aminoacetonitrile; Cell Movement; Cholangiocarcinoma; Cyclic S-Oxides; Flavonoids; Humans; Indoles; Peptides; Piperazines; Receptor, PAR-2; Signal Transduction; Structure-Activity Relationship; Sulfonamides; Sulfones; Tumor Cells, Cultured

2012
Pertussis toxin-sensitive heterotrimeric G(αi/o) proteins mediate WNT/β-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.
    Cellular signalling, 2013, Volume: 25, Issue:4

    Topics: Aminoacetonitrile; Animals; beta Catenin; Calcium; Cells, Cultured; Cyclooxygenase 2; GTP-Binding Protein alpha Subunits, Gi-Go; Intercellular Signaling Peptides and Proteins; Kinetics; Low Density Lipoprotein Receptor-Related Protein-6; Mice; Mice, Inbred C57BL; Microglia; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pertussis Toxin; Phosphorylation; Recombinant Proteins; Signal Transduction; Type C Phospholipases; Wnt Proteins; Wnt3A Protein

2013
Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum.
    Neuropharmacology, 2013, Volume: 70

    Topics: Acetylation; Aminoacetonitrile; Animals; Cytoskeletal Proteins; Epigenesis, Genetic; Gene Expression; Histones; Male; MAP Kinase Signaling System; Methyl-CpG-Binding Protein 2; Morphine; Naloxone; Nerve Tissue Proteins; Neurons; Nucleus Accumbens; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Septal Nuclei; Signal Transduction; Substance Withdrawal Syndrome

2013
Cognitive improvement by acute growth hormone is mediated by NMDA and AMPA receptors and MEK pathway.
    Progress in neuro-psychopharmacology & biological psychiatry, 2013, Aug-01, Volume: 45

    Topics: Age Factors; Aminoacetonitrile; Animals; Dizocilpine Maleate; Drug Interactions; Excitatory Amino Acid Antagonists; Growth Hormone; Male; MAP Kinase Signaling System; Memory, Short-Term; Mice; Protease Inhibitors; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate

2013
Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1.
    Neuropharmacology, 2013, Volume: 72

    Topics: Adenosine A2 Receptor Antagonists; Aminoacetonitrile; Animals; Clozapine; Corpus Striatum; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Antagonists; GABA Antagonists; Gene Expression Regulation; Haloperidol; In Vitro Techniques; Male; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiprotein Complexes; Mutation; Phosphorylation; Protease Inhibitors; Protein Phosphatase 1; Purines; Ribosomal Protein S6; Signal Transduction; TOR Serine-Threonine Kinases

2013
Activation of ERK1/2 is required for normal response of isosexual social interactions in male rats.
    Brain research, 2013, Nov-13, Volume: 1538

    Topics: Aminoacetonitrile; Animals; Brain; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Olfactory Mucosa; Phosphorylation; Rats; Rats, Sprague-Dawley; Social Behavior; Zinc Sulfate

2013
A causative link between inner ear defects and long-term striatal dysfunction.
    Science (New York, N.Y.), 2013, Sep-06, Volume: 341, Issue:6150

    Topics: Aminoacetonitrile; Animals; Corpus Striatum; Cyclic AMP Response Element-Binding Protein; Ear, Inner; Extracellular Signal-Regulated MAP Kinases; Hyperkinesis; Labyrinth Diseases; Mental Disorders; Mice; Mice, Knockout; Motor Activity; Neuronal Plasticity; Nucleus Accumbens; Organ of Corti; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2

2013
Variations in the stimulus salience of cocaine reward influences drug-associated contextual memory.
    Addiction biology, 2016, Volume: 21, Issue:2

    Topics: Aminoacetonitrile; Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Male; Memory; Mice, Inbred C57BL; Nitric Oxide Synthase Type I; Piperidines; Receptors, N-Methyl-D-Aspartate; Reward

2016
Inhibition of ERK1/2 signaling prevents epileptiform behavior in rats prone to audiogenic seizures.
    Journal of neurochemistry, 2015, Volume: 132, Issue:2

    Topics: Acoustic Stimulation; Aminoacetonitrile; Animals; Brain; CREB-Binding Protein; Epilepsy, Reflex; Exocytosis; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nerve Tissue Proteins; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Rats; Rats, Mutant Strains; Reaction Time; Synapses; Synapsins; Synaptosomal-Associated Protein 25; Vesicle-Associated Membrane Protein 2; Vesicular Glutamate Transport Protein 2

2015
Alcohol alters the activation of ERK1/2, a functional regulator of binge alcohol drinking in adult C57BL/6J mice.
    Alcoholism, clinical and experimental research, 2015, Volume: 39, Issue:3

    Topics: Aminoacetonitrile; Animals; Binge Drinking; Enzyme Activation; Ethanol; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Protease Inhibitors

2015
Transient Blockade of ERK Phosphorylation in the Critical Period Causes Autistic Phenotypes as an Adult in Mice.
    Scientific reports, 2015, May-20, Volume: 5

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Aminoacetonitrile; Animals; Apoptosis; Autistic Disorder; Behavior, Animal; Caspase 3; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Immunohistochemistry; Long-Term Potentiation; Mice; Mice, Inbred C57BL; Mice, Knockout; N-Methylaspartate; Phenotype; Phosphorylation; Protein Isoforms

2015
Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice.
    Psychopharmacology, 2015, Volume: 232, Issue:18

    Topics: Aminoacetonitrile; Amygdala; Animals; Brain; Central Nervous System Depressants; Conditioning, Operant; Ethanol; Extracellular Signal-Regulated MAP Kinases; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Motor Activity; Nucleus Accumbens; Phosphorylation; Prefrontal Cortex; Protease Inhibitors; Reinforcement, Psychology; Reward; Self Administration

2015
Suppression of ERK phosphorylation through oxidative stress is involved in the mechanism underlying sevoflurane-induced toxicity in the developing brain.
    Scientific reports, 2016, Feb-24, Volume: 6

    Topics: Aminoacetonitrile; Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blood-Brain Barrier; Blotting, Western; Brain; Caspase 3; Hydrogen; Methyl Ethers; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidative Stress; Phosphorylation; Reactive Oxygen Species; Sevoflurane; Time Factors

2016
ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress.
    Brain research bulletin, 2016, Volume: 124

    Topics: Aminoacetonitrile; Animals; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Corticosterone; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Food Deprivation; Food Preferences; Gene Expression Regulation; Hesperidin; Hippocampus; Male; Mice; Mice, Inbred ICR; Phosphorylation; Protease Inhibitors; Stress, Psychological; Sucrose

2016
Differential effects of the MEK inhibitor SL327 on the acquisition and expression of ethanol-elicited conditioned place preference and aversion in mice.
    Journal of psychopharmacology (Oxford, England), 2017, Volume: 31, Issue:1

    Topics: Aminoacetonitrile; Animals; Behavior, Animal; Conditioning, Psychological; Ethanol; Extracellular Signal-Regulated MAP Kinases; Learning; Male; Mice; Motivation; Motor Activity; Neurons; Nucleus Accumbens; Reward

2017
Activation of Extracellular Signal-Regulated Kinases (ERK 1/2) in the Locus Coeruleus Contributes to Pain-Related Anxiety in Arthritic Male Rats.
    The international journal of neuropsychopharmacology, 2017, 06-01, Volume: 20, Issue:6

    Topics: Action Potentials; Aminoacetonitrile; Animals; Anxiety; Arthritis, Experimental; Cohort Studies; Extracellular Signal-Regulated MAP Kinases; Freund's Adjuvant; Locus Coeruleus; Male; Neurons; Nociception; Pain; Phosphorylation; Protease Inhibitors; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase

2017
Combination of SL327 and Sunitinib Malate leads to an additive anti-cancer effect in doxorubicin resistant thyroid carcinoma cells.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 88

    Topics: Aminoacetonitrile; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspase 3; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Survival; Docetaxel; Doxorubicin; Drug Resistance, Neoplasm; Humans; Indoles; Mice, Nude; Pyrroles; Sunitinib; Taxoids; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms

2017
Negative regulation of ERK1/2 by PI3K is required for the protective effects of Pyropia yezoensis peptide against perfluorooctane sulfonate-induced endoplasmic reticulum stress.
    Molecular medicine reports, 2017, Volume: 15, Issue:5

    Topics: Alkanesulfonic Acids; Amino Acid Sequence; Aminoacetonitrile; Cell Line, Tumor; Cell Survival; Chromones; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Fluorocarbons; Heat-Shock Proteins; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Morpholines; Peptides; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protective Agents; Receptors, G-Protein-Coupled; Rhodophyta; Up-Regulation

2017
Mechanistic Target of Rapamycin-Independent Antidepressant Effects of (R)-Ketamine in a Social Defeat Stress Model.
    Biological psychiatry, 2018, Jan-01, Volume: 83, Issue:1

    Topics: Aminoacetonitrile; Animals; Antidepressive Agents; Brain; Chronic Disease; Depressive Disorder; Disease Models, Animal; Dominance-Subordination; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Ketamine; Male; Mice, Inbred C57BL; Morpholines; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Sirolimus; Stress, Psychological; TOR Serine-Threonine Kinases

2018
Effects of ERK1/2 kinases inactivation on the nigrostriatal system of Krushinsky-Molodkina rats genetically prone to audiogenic seizures.
    Neurological research, 2017, Volume: 39, Issue:10

    Topics: Acoustic Stimulation; Aminoacetonitrile; Animals; Auditory Perception; Corpus Striatum; Disease Models, Animal; Female; gamma-Aminobutyric Acid; Glutamic Acid; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Protein Kinase Inhibitors; Rats; Seizures; Substantia Nigra; Synapsins

2017
The role of verapamil and SL-327 in morphine- and ethanol-induced state-dependent and cross state-dependent memory.
    European journal of pharmacology, 2018, Sep-05, Volume: 834

    Topics: Aminoacetonitrile; Animals; Behavior, Addictive; Cognition; Ethanol; Male; Memory; Mice; Morphine; Verapamil

2018
Social support rescues acute stress-induced cognitive impairments by modulating ERK1/2 phosphorylation in adolescent mice.
    Scientific reports, 2018, 08-13, Volume: 8, Issue:1

    Topics: Age Factors; Aminoacetonitrile; Animal Communication; Animals; Cognitive Dysfunction; Corticosterone; Early Growth Response Protein 1; Male; MAP Kinase Signaling System; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphorylation; Prefrontal Cortex; Protease Inhibitors; Social Behavior; Stress, Psychological; Transcriptional Activation; Up-Regulation

2018
Differential effects of MEK inhibitors on rat neural stem cell differentiation: Repressive roles of MEK2 in neurogenesis and induction of astrocytogenesis by PD98059.
    Pharmacological research, 2019, Volume: 149

    Topics: Aminoacetonitrile; Animals; Astrocytes; Butadienes; Cells, Cultured; Flavonoids; MAP Kinase Kinase 2; MAP Kinase Signaling System; Neural Stem Cells; Neurogenesis; Nitriles; Protein Kinase Inhibitors; Rats

2019
    Proceedings of the National Academy of Sciences of the United States of America, 2020, 03-17, Volume: 117, Issue:11

    Topics: Aminoacetonitrile; Animals; Cells, Cultured; Cerebral Cortex; Disease Models, Animal; Embryo, Mammalian; Female; GABAergic Neurons; Humans; Interneurons; LIM-Homeodomain Proteins; MAP Kinase Signaling System; Median Eminence; Mice; Mice, Knockout; Nerve Tissue Proteins; Neurofibromatosis 1; Neurofibromin 1; Neuroglia; Parvalbumins; Primary Cell Culture; ras GTPase-Activating Proteins; Somatostatin; Transcription Factors

2020
Diazepam and SL-327 synergistically attenuate anxiety-like behaviours in mice - Possible hippocampal MAPKs specificity.
    Neuropharmacology, 2020, 12-01, Volume: 180

    Topics: Aminoacetonitrile; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Drug Synergism; Hippocampus; Male; MAP Kinase Signaling System; Maze Learning; Mice; Motor Activity

2020
α-[Amino(4-aminophenyl)thio]methylene-2-(trifluoromethyl)benzeneacetonitrile; Configurational equilibria in solution.
    Bioorganic chemistry, 2021, Volume: 113

    Topics: Aminoacetonitrile; Molecular Structure; Solutions

2021
Inhibition of extracellular signal-regulated kinase pathway suppresses tracheal stenosis in a novel mouse model.
    PloS one, 2021, Volume: 16, Issue:9

    Topics: Aminoacetonitrile; Animals; Cell Proliferation; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Protease Inhibitors; Signal Transduction; Tracheal Stenosis

2021