Page last updated: 2024-08-21

aminoacetonitrile and monepantel

aminoacetonitrile has been researched along with monepantel in 80 studies

Research

Studies (80)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	13 (16.25)	29.6817
2010's	62 (77.50)	24.3611
2020's	5 (6.25)	2.80

Authors

Authors	Studies
Hosking, BC; Kaminsky, R; Mosimann, D; Seewald, W; Stein, PA; Strehlau, G	1
Hosking, B; Kaminsky, R; Mosimann, D; Sager, H; Stein, P	1
Bapst, B; Hosking, B; Kaminsky, R; Sager, H; Stein, P; Vanhoff, K	1
Bapst, B; Dobson, DP; Hosking, BC; Kaminsky, R; Mason, PC; Mosimann, D; Sager, H; Seewald, W; Stein, PA; Strehlau, G	1
Chamberlain, B; Cole, DJ; Griffiths, TM; Hosking, BC; Kaye-Smith, BG; Mason, PC; McKay, CH; Nottingham, RM; Seewald, W	1
Alexander, A; Helbig, R; Hosking, BC; Malikides, N; Roth, DR; Strehlau, GA	1
Baker, K; Debenedetti, R; George, B; Hall, C; Helbig, R; Mahoney, R; Malikides, N; Spencer, K; Strehlau, GA; Vanhoff, K	1
Kaminsky, R; Mäser, P; Roditi, I; Rufener, L	1
Hosking, BC; Stein, PA	1
Bouvier, J; Browning, A; Giraudel, JM; Karadzovska, D; Seewald, W; Smal, M	1
Baker, K; Debenedetti, R; Hall, C; Mahoney, R; Malikides, N; Spencer, K; Strehlau, GA; Vanhoff, K	1
Bonino Morlán, J; Bustamante, M; Cardozo, H; Castells, D; Echevarria, F; Fiel, CA; Hosking, BC; Steffan, PE	1
Hosking, BC; Kaminsky, R; Rolfe, PF; Sager, H; Seewald, W	1
Besier, RB; Griffiths, TM; Hosking, BC; Kaye-Smith, BG; Le Feuvre, AS; Nilon, P; Seewald, W; Trengove, C; Vanhoff, KJ; Woodgate, RG	1
Giraudel, JM; Hosking, BC; Kaminsky, R; Karadzovska, D; Sager, H; Seewald, W; Vercruysse, J	1
Hosking, BC; Rolfe, PF; Stein, PA	1
Allan, B; Hosking, B; Kaminsky, R; Rolfe, P; Sager, H; Strehlau, G	1
van Dijk, J	2
Giraudel, JM; Hosking, BC; House, JK; Karadzovska, D; Seewald, W; Stein, PA	1
Baur, R; Kaminsky, R; Mäser, P; Rufener, L; Sigel, E	1
Kaminsky, R; Keiser, J; Mäser, P; Nilsson, D; Rufener, L	1
Hoffmann, S; Skripsky, T	1
Allan, BA; Bapst, B; Hosking, BC; Kaminsky, R; Rolfe, PF; Sager, H; Stein, PA; Strehlau, GA	1
Francis, A; Geary, TG; Ruiz-Lancheros, E; Viau, C; Walter, TN	1
Dobson, DP; Hunter, RP; Jones, MD; Kubacki, P; Reymond, N; Strehlau, GA; Tranchard, ES; Walters, ME	1
Bailey, JN; Besier, RB; Dobson, RJ; Hosking, BC; Larsen, JW; Love, S; Rolfe, PF	1
Clark, JN; Don, R; Horton, J; Keiser, J; Kuesel, A; Olliaro, P; Seiler, J	1
Byrne, P; Cantwell, H; Danaher, M; Furey, A; Kinsella, B; McCormack, M	1
George, SD; Hosking, BC; Rolfe, PF; Stein, PA	1
Emmerich, IU	1
Leathwick, DM	1
Baker, KE; George, SD; Hosking, BC; Rolfe, PF; Seewald, W; Stein, PA	1
Bartley, DJ; Cody, R; Hosking, BC; Jackson, F; Ramage, C	1
Keiser, J; Silbereisen, A; Tritten, L	1
George, AJ; George, SD; Hosking, BC; Rolfe, PF; Seewald, W; Stein, PA	1
Bapst, B; Kaminsky, R; Sager, H; Strehlau, GA	1
Bártíková, H; Holčapek, M; Jirásko, R; Lamka, J; Pour, M; Skálová, L; Spulák, M; Stuchlíková, L; Szotáková, B; Vokřál, I	1
Asanger, H; Dadak, AM; Franz, S; Tichy, A	1
Barley, JP; Bartley, DJ; Brennan, GP; Edgar, HW; Ellison, SE; Fairweather, I; Hanna, RE; Malone, FE; McMahon, C	1
Baur, R; Bedoni, N; Beech, R; Bouvier, J; Glauser, DA; Puoti, A; Rey, S; Rufener, L; Sigel, E	1
Adlington, B; Kenyon, PR; Moss, A; Pomroy, WE; Scott, I; Smith, G	1
Holčapek, M; Jirásko, R; Lamka, J; Skálová, L; Stuchlíková, L; Szotáková, B; Valát, M; Vokřál, I	1
Ballent, M; Lanusse, C; Lifschitz, A; Sallovitz, J; Virkel, G; Viviani, P	1
Lecová, L; Prchal, L; Skálová, L; Stuchlíková, L	1
Baur, R; Beech, R; Rufener, L; Sigel, E	1
Banchero, GE; Mederos, AE; Ramos, Z	1
Bártíková, H; Kubíček, V; Lamka, J; Matoušková, P; Pětníková, H; Skálová, L; Štolcová, T; Stuchlíková, L; Szotáková, B; Vokřál, I	1
Kappert, C; Moll, L; Van den Brom, R; Vellema, P	1
Holčapek, M; Jirásko, R; Lamka, J; Lecová, L; Skálová, L; Stuchlíková, L; Szotáková, B; Vokřál, I	1
Bartley, DJ; Devin, L; Morrison, AA; Nath, M	1
Alvarez, L; Lanusse, C; Lifschitz, A	2
Cintra, MC; Nascimento, LV; Sotomaior, CS; Teixeira, VN	1
Ballent, M; Lanusse, C; Lifschitz, A; Maté, L; Virkel, G; Viviani, P	1
Chambers, M; Hunt, PW; Kotze, AC; Lamb, J; Raza, A	1
Bartley, DJ; Devin, L; Donegan, H; Meslé, M; Morrison, AA	1
Baell, J; Crawford, S; Gasser, RB; Hofmann, A; Hu, M; Jabbar, A; Luo, J; Preston, S; Zhang, Y; Zhou, HB	1
Love, S; Sales, N	1
Blacque, O; Gasser, G; Gasser, RB; Hess, J; Jabbar, A; Jorgensen, EM; Konatschnig, S; Mac, P; Patra, M; Rangasamy, L	1
Amarante, AFT; Bassetto, CC; de Albuquerque, ACA; de Almeida, FA	1
Elliott, TP; Kotze, AC; Lamb, J; Ruffell, A	1
Araújo, JFM; Brito, DRB; Costa-Júnior, LM; Cutrim-Júnior, JAA; Garcia, JL; Louvandini, H; Soares, EDS; Torres-Acosta, JFJ	1
Bartley, D; Hamer, K; Jennings, A; Morrison, A; Sargison, N	1
Everts, RR; Ploeger, HW	1
Barioni-Júnior, W; Brito, ES; Canuto, KM; Chagas, ACS; Esteves, SN; Figueiredo, A; Lopes, LG; Ribeiro, PRV; Silva, MH; Souza, ASQ	1
Amarante, AFT; Benavides, MV; Chagas, ACS; Cruvinel, GG; Esteves, SN; Moraes, CV; Niciura, SCM	1
Cintra, MCR; Nascimento, LV; Ollhoff, RD; Sotomaior, CS; Teixeira, VN	1
Hinney, B; Joachim, A; Kultscher, L; Schmäschke, R; Wittek, T	1
Jakubec, P; Langhansová, L; Navrátilová, M; Podlipná, R; Skálová, L; Stuchlíková, LR; Szotáková, B	1
Benavides, MV; Chagas, ACS; Cruvinel, GG; de Albuquerque, ACA; do Amarante, AFT; Esteves, SN; Moraes, CV; Niciura, SCM; Santana, RCM; Tizioto, PC	1
Bartley, DJ; Devaney, E; Laing, R; Morrison, AA; Turnbull, F	1
Marjanović, DS; Milovanović, M; Robertson, AP; Todorović, Z; Trailović, JN; Trailović, SM; Zdravković, N	1
Aston, R; Brown, MP; Fairlie, WD; Harris, TJ; Lee, EF; Mislang, A; Mollard, R; Tapia Rico, G	1
Enweji, N; Gustafsson, K; Höglund, J	1
Brito, DRB; Chaudhry, UN; Costa-Junior, LM; Cutrim-Júnior, JAA; Sargison, ND; Silva, CR; Silva, NC; Sousa, DM	1
Martins, IVF; Scott, FB; Silva, YHD; Viana, MVG	1

Reviews

4 review(s) available for aminoacetonitrile and monepantel

Article	Year
A pooled analysis of the efficacy of monepantel, an amino-acetonitrile derivative against gastrointestinal nematodes of sheep. Parasitology research, 2010, Volume: 106, Issue:2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Controlled Clinical Trials as Topic; Gastrointestinal Diseases; Nematoda; Nematode Infections; Sheep; Sheep Diseases; Treatment Outcome	2010
[New drugs for horses and production animals in 2010]. Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere, 2011, Volume: 39, Issue:6 Topics: 4-Butyrolactone; Aminoacetonitrile; Animals; Animals, Domestic; Anthelmintics; Anti-Bacterial Agents; Cattle; Chickens; Cyclooxygenase 2 Inhibitors; Dopamine Agonists; Doxycycline; Germany; Horses; Macrolides; Pergolide; Sheep; Sulfones; Swine; Turkeys; Veterinary Drugs	2011
Basic and clinical pharmacology contribution to extend anthelmintic molecules lifespan. Veterinary parasitology, 2015, Aug-15, Volume: 212, Issue:1-2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Helminths; Indoles; Oxepins; Pharmacology, Clinical; Ruminants; Time	2015
Host pharmacokinetics and drug accumulation of anthelmintics within target helminth parasites of ruminants. New Zealand veterinary journal, 2017, Volume: 65, Issue:4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Benzimidazoles; Cattle; Cattle Diseases; Cestoda; Haemonchus; Helminthiasis, Animal; Helminths; Lactones; Ruminants; Salicylanilides; Sheep; Sheep Diseases	2017

Trials

16 trial(s) available for aminoacetonitrile and monepantel

Article	Year
Dose determination studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Veterinary parasitology, 2008, Oct-20, Volume: 157, Issue:1-2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Dose-Response Relationship, Drug; Female; Larva; Male; Nematoda; Nematode Infections; Sheep; Sheep Diseases	2008
Safety of an amino-acetonitrile derivative (AAD), monepantel, in ewes and their offspring following repeated oral administration. New Zealand veterinary journal, 2009, Volume: 57, Issue:4 Topics: Administration, Oral; Aminoacetonitrile; Analysis of Variance; Animals; Animals, Newborn; Anthelmintics; Autopsy; Female; Male; Pregnancy; Pregnancy, Animal; Reproduction; Sheep	2009
The efficacy of monepantel, an amino-acetonitrile derivative, against gastrointestinal nematodes of sheep in three countries of southern Latin America. Parasitology research, 2009, Volume: 106, Issue:1 Topics: Aminoacetonitrile; Animals; Antinematodal Agents; Argentina; Brazil; Feces; Female; Gastrointestinal Diseases; Male; Nematode Infections; Parasite Egg Count; Sheep; Sheep Diseases; Treatment Outcome; Uruguay	2009
Clinical field study to evaluate the efficacy and safety of the amino-acetonitrile derivative, monepantel, compared with registered anthelmintics against gastrointestinal nematodes of sheep in Australia. Australian veterinary journal, 2009, Volume: 87, Issue:11 Topics: Aminoacetonitrile; Animals; Anthelmintics; Australia; Drug Resistance; Feces; Female; Helminthiasis, Animal; Intestinal Diseases, Parasitic; Male; Parasite Egg Count; Sheep; Sheep Diseases; Treatment Outcome	2009
Quarantine treatment of sheep with monepantel--rapidity of fecal egg count reduction. Veterinary parasitology, 2010, Jun-24, Volume: 170, Issue:3-4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Australia; Feces; Gastrointestinal Diseases; Nematode Infections; Parasite Egg Count; Quarantine; Sheep; Sheep Diseases; Switzerland	2010
Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep. The Veterinary record, 2010, Apr-17, Volume: 166, Issue:16 Topics: Abomasum; Administration, Oral; Aminoacetonitrile; Animals; Anthelmintics; Drug Administration Routes; Rumen; Sheep; Sheep Diseases; Trichostrongyloidea; Trichostrongyloidiasis	2010
European field study of the efficacy and safety of the novel anthelmintic monepantel in sheep. The Veterinary record, 2010, Oct-16, Volume: 167, Issue:16 Topics: Administration, Oral; Aminoacetonitrile; Animals; Anthelmintics; Double-Blind Method; England; France; Gastrointestinal Diseases; Helminthiasis, Animal; Nematode Infections; Parasite Egg Count; Scotland; Sheep; Sheep Diseases; Treatment Outcome	2010
Safety and efficacy against fourth-stage gastrointestinal nematode larvae, of monepantel in 6-week old lambs. Veterinary parasitology, 2012, Apr-30, Volume: 185, Issue:2-4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Female; Male; Nematode Infections; Sheep; Sheep Diseases	2012
Efficacy of monepantel and anthelmintic combinations against multiple-resistant Haemonchus contortus in sheep, including characterisation of the nematode isolate. Veterinary parasitology, 2012, May-25, Volume: 186, Issue:3-4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Therapy, Combination; Female; Haemonchiasis; Haemonchus; Male; Sheep; Sheep Diseases	2012
The efficacy of monepantel against naturally acquired inhibited and developing fourth-stage larvae of Teladorsagia circumcincta in sheep in the United Kingdom. Veterinary parasitology, 2012, May-25, Volume: 186, Issue:3-4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Female; Larva; Male; Nematoda; Nematode Infections; Sheep; Sheep Diseases; United Kingdom	2012
The comparative efficacy of abamectin, monepantel and an abamectin/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep. Veterinary parasitology, 2012, Aug-13, Volume: 188, Issue:1-2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Combinations; Indoles; Ivermectin; Larva; Nematoda; Nematode Infections; Oxepins; Sheep; Sheep Diseases	2012
Efficacy of monepantel, derquantel and abamectin against adult stages of a multi-resistant Haemonchus contortus isolate. Parasitology research, 2012, Volume: 111, Issue:5 Topics: Aminoacetonitrile; Animals; Anthelmintics; Disease Models, Animal; Feces; Haemonchiasis; Haemonchus; Indoles; Ivermectin; Oxepins; Parasite Egg Count; Sheep; Treatment Outcome	2012
Establishing an efficacious dose rate of monepantel for treating gastrointestinal nematodes in llamas under field conditions. The Veterinary record, 2013, Feb-09, Volume: 172, Issue:6 Topics: Aminoacetonitrile; Animals; Antinematodal Agents; Camelids, New World; Gastrointestinal Diseases; Nematode Infections; Treatment Outcome	2013
Lack of efficacy of monepantel against Teladorsagia circumcincta and Trichostrongylus colubriformis. Veterinary parasitology, 2013, Nov-15, Volume: 198, Issue:1-2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Feces; Goat Diseases; Goats; Parasite Egg Count; Sheep; Sheep Diseases; Trichostrongyloidea	2013
Development of Haemonchus contortus resistance in sheep under suppressive or targeted selective treatment with monepantel. Veterinary parasitology, 2017, Nov-15, Volume: 246 Topics: Aminoacetonitrile; Animals; Anthelmintics; Body Weight; Dose-Response Relationship, Drug; Drug Resistance; Feces; Haemonchiasis; Male; Parasite Egg Count; Sheep; Sheep Diseases	2017
A preliminary assessment of oral monepantel's tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors. Cancer chemotherapy and pharmacology, 2020, Volume: 86, Issue:5 Topics: Administration, Oral; Adult; Aminoacetonitrile; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Early Termination of Clinical Trials; Female; Humans; Inhibitory Concentration 50; Male; Maximum Tolerated Dose; Neoplasms; Positron Emission Tomography Computed Tomography; Sulfones; TOR Serine-Threonine Kinases; Veterinary Drugs	2020

Other Studies

60 other study(ies) available for aminoacetonitrile and monepantel

Article	Year
Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep. International journal for parasitology, 2009, Volume: 39, Issue:4 Topics: Aminoacetonitrile; Animals; Antinematodal Agents; Dose-Response Relationship, Drug; Feces; Nematoda; Nematode Infections; Parasite Egg Count; Sheep; Sheep Diseases	2009
Efficacy of the amino-acetonitrile derivative, monepantel, against experimental and natural adult stage gastro-intestinal nematode infections in sheep. Veterinary parasitology, 2009, Jan-22, Volume: 159, Issue:1 Topics: Aminoacetonitrile; Animals; Anthelmintics; Gastrointestinal Diseases; Nematoda; Nematode Infections; Parasite Egg Count; Sheep; Sheep Diseases	2009
Dose confirmation studies for monepantel, an amino-acetonitrile derivative, against fourth stage gastro-intestinal nematode larvae infecting sheep. Veterinary parasitology, 2009, Mar-23, Volume: 160, Issue:3-4 Topics: Aminoacetonitrile; Animals; Antinematodal Agents; Dose-Response Relationship, Drug; Female; Intestinal Diseases, Parasitic; Larva; Male; Nematoda; Nematode Infections; Parasite Egg Count; Parasitic Sensitivity Tests; Sheep; Sheep Diseases; Species Specificity; Treatment Outcome	2009
A large-scale clinical field study to evaluate the efficacy and safety of an oral formulation of the amino-acetonitrile derivative ( AAD ), monepantel , in sheep in New Zealand. New Zealand veterinary journal, 2009, Volume: 57, Issue:1 Topics: Administration, Oral; Aminoacetonitrile; Animals; Antinematodal Agents; Drug Resistance; Feces; Female; Male; Nematoda; Nematode Infections; New Zealand; Parasite Egg Count; Random Allocation; Sheep; Sheep Diseases; Treatment Outcome	2009
Safety of an amino-acetonitrile derivative ( AAD ), monepantel, in weaned lambs following repeated oral administration. New Zealand veterinary journal, 2009, Volume: 57, Issue:1 Topics: Administration, Oral; Aminoacetonitrile; Animals; Animals, Newborn; Anthelmintics; Dose-Response Relationship, Drug; Female; Male; Random Allocation; Safety; Sheep; Sheep Diseases; Treatment Outcome	2009
Reproductive safety of an amino-acetonitrile derivative (AAD), monepantel, in rams following repeated oral administration. New Zealand veterinary journal, 2009, Volume: 57, Issue:1 Topics: Administration, Oral; Aminoacetonitrile; Animals; Anthelmintics; Double-Blind Method; Helminthiasis, Animal; Male; Organ Size; Random Allocation; Reproduction; Sheep; Sheep Diseases; Spermatozoa; Weight Gain	2009
Haemonchus contortus acetylcholine receptors of the DEG-3 subfamily and their role in sensitivity to monepantel. PLoS pathogens, 2009, Volume: 5, Issue:4 Topics: Amino Acid Sequence; Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Gene Library; Genes, Helminth; Haemonchus; Helminth Proteins; Molecular Sequence Data; Mutation; Phylogeny; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction	2009
Effect of fasting sheep for a short period on the efficacy and safety of monepantel. The Veterinary record, 2009, Jul-11, Volume: 165, Issue:2 Topics: Aminoacetonitrile; Animals; Antinematodal Agents; Disease Models, Animal; Euthanasia, Animal; Fasting; Larva; Parasitic Sensitivity Tests; Sheep; Sheep Diseases; Trichostrongyloidea; Trichostrongyloidiasis	2009
Pharmacokinetics of monepantel and its sulfone metabolite, monepantel sulfone, after intravenous and oral administration in sheep. Journal of veterinary pharmacology and therapeutics, 2009, Volume: 32, Issue:4 Topics: Administration, Oral; Aminoacetonitrile; Animals; Anthelmintics; Biological Availability; Chromatography, High Pressure Liquid; Feces; Female; Infusions, Intravenous; Male; Sheep; Sulfones; Validation Studies as Topic	2009
The effect of sheep breed, age, and gender on the pharmacokinetics and efficacy of monepantel, an amino-acetonitrile derivative. Parasitology research, 2010, Volume: 106, Issue:2 Topics: Age Factors; Aminoacetonitrile; Animals; Anthelmintics; Female; Helminthiasis, Animal; Male; Pedigree; Sex Factors; Sheep; Sheep Diseases	2010
The control of inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep in Australia with monepantel. Veterinary parasitology, 2010, May-11, Volume: 169, Issue:3-4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Australia; Female; Haemonchiasis; Haemonchus; Larva; Male; Sheep; Sheep Diseases; Treatment Outcome; Trichostrongyloidea; Trichostrongyloidiasis	2010
Use of monepantel. The Veterinary record, 2010, Apr-10, Volume: 166, Issue:15 Topics: Aminoacetonitrile; Animals; Anthelmintics; Parasitic Diseases, Animal	2010
Monepantel allosterically activates DEG-3/DES-2 channels of the gastrointestinal nematode Haemonchus contortus. Molecular pharmacology, 2010, Volume: 78, Issue:5 Topics: Allosteric Regulation; Aminoacetonitrile; Animals; Anthelmintics; Choline; Female; Haemonchus; Nicotinic Agonists; Oocytes; Protein Subunits; Receptors, GABA; Receptors, Nicotinic; Stereoisomerism; Sulfones; Xenopus laevis	2010
Phylogenomics of ligand-gated ion channels predicts monepantel effect. PLoS pathogens, 2010, Sep-09, Volume: 6, Issue:9 Topics: Aminoacetonitrile; Animals; Anthelmintics; Antinematodal Agents; Caenorhabditis elegans Proteins; Drug Resistance; Genome, Helminth; Haemonchiasis; Haemonchus; Ligand-Gated Ion Channels; Nematoda; Nematode Infections; Parasite Egg Count; Phylogeny; Receptors, Nicotinic; Sheep; Sheep Diseases; Treatment Outcome	2010
Assessment of risk of monepantel faecal residues to dung fauna. Australian veterinary journal, 2010, Volume: 88, Issue:12 Topics: Aminoacetonitrile; Animals; Anthelmintics; Cattle; Coleoptera; Diptera; Dose-Response Relationship, Drug; Drug Residues; Environmental Exposure; Feces; Larva; Lethal Dose 50; Risk Assessment	2010
Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep. Parasitology research, 2011, Volume: 109, Issue:1 Topics: Aminoacetonitrile; Animals; Anthelmintics; Australia; Drug Resistance; Haemonchus; Ivermectin; Larva; Nematode Infections; Sheep; Sheep Diseases; Treatment Outcome; Trichostrongylus	2011
Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans. International journal for parasitology, 2011, Volume: 41, Issue:3-4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Caenorhabditis elegans; Dose-Response Relationship, Drug; Drug Interactions; Indolizines; Levamisole; Nicotine; Nicotinic Agonists; Parasitic Sensitivity Tests; Pyrantel; Receptors, Nicotinic; Spiro Compounds	2011
Use of monepantel. The Veterinary record, 2010, Oct-09, Volume: 167, Issue:15 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Seasons; United Kingdom	2010
Minimising the development of anthelmintic resistance, and optimising the use of the novel anthelmintic monepantel, for the sustainable control of nematode parasites in Australian sheep grazing systems. Australian veterinary journal, 2011, Volume: 89, Issue:5 Topics: Aminoacetonitrile; Animal Husbandry; Animals; Anthelmintics; Australia; Benzimidazoles; Drug Resistance; Drug Resistance, Multiple; Drug Therapy, Combination; Female; Helminthiasis, Animal; Ivermectin; Levamisole; Male; Sheep; Sheep Diseases; Treatment Outcome	2011
Potential drug development candidates for human soil-transmitted helminthiases. PLoS neglected tropical diseases, 2011, Volume: 5, Issue:6 Topics: Aminoacetonitrile; Animals; Anthelmintics; Depsipeptides; Drug Approval; Drug Evaluation, Preclinical; Europe; Helminthiasis; Helminthiasis, Animal; Humans; Nitro Compounds; Thiazoles; United States	2011
Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2011, Dec-01, Volume: 879, Issue:31 Topics: Aminoacetonitrile; Animals; Chromatography, High Pressure Liquid; Drug Residues; Goats; Limit of Detection; Linear Models; Milk; Muscles; Reproducibility of Results; Sheep; Sulfones; Tandem Mass Spectrometry	2011
Modelling the benefits of a new class of anthelmintic in combination. Veterinary parasitology, 2012, May-04, Volume: 186, Issue:1-2 Topics: Aminoacetonitrile; Animal Husbandry; Animals; Anthelmintics; Computer Simulation; Drug Resistance; Drug Therapy, Combination; Gene Frequency; Genotype; Indoles; Ivermectin; Nematoda; Nematode Infections; New Zealand; Oxepins; Sheep; Sheep Diseases; Sheep, Domestic; Time Factors	2012
In vitro and in vivo efficacy of Monepantel (AAD 1566) against laboratory models of human intestinal nematode infections. PLoS neglected tropical diseases, 2011, Volume: 5, Issue:12 Topics: Administration, Oral; Aminoacetonitrile; Animals; Anthelmintics; Cricetinae; Disease Models, Animal; Female; Inhibitory Concentration 50; Locomotion; Male; Mesocricetus; Mice; Mice, Inbred C57BL; Nematoda; Nematode Infections; Rats; Treatment Outcome	2011
Investigation of the metabolism of monepantel in ovine hepatocytes by UHPLC/MS/MS. Analytical and bioanalytical chemistry, 2013, Volume: 405, Issue:5 Topics: Aminoacetonitrile; Animals; Anthelmintics; Cells, Cultured; Chromatography, High Pressure Liquid; Hepatocytes; Metabolic Networks and Pathways; Sheep; Solid Phase Extraction; Tandem Mass Spectrometry	2013
Anthelmintic resistance in Northern Ireland (I): prevalence of resistance in ovine gastrointestinal nematodes, as determined through faecal egg count reduction testing. Veterinary parasitology, 2013, Jul-01, Volume: 195, Issue:1-2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Antinematodal Agents; Benzimidazoles; Drug Resistance; Feces; Gastrointestinal Diseases; Ivermectin; Levamisole; Macrolides; Northern Ireland; Parasite Egg Count; Prevalence; Sheep; Sheep Diseases; Sheep, Domestic; Treatment Outcome; Trichostrongyloidea; Trichostrongyloidiasis	2013
acr-23 Encodes a monepantel-sensitive channel in Caenorhabditis elegans. PLoS pathogens, 2013, Volume: 9, Issue:8 Topics: Aminoacetonitrile; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Drug Resistance; Gene Expression Regulation; Ion Channels; Mutation; Organ Specificity; Xenopus laevis	2013
Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus). Drug testing and analysis, 2014, Volume: 6, Issue:10 Topics: Aminoacetonitrile; Animals; Anthelmintics; Chromatography, High Pressure Liquid; Haemonchus; Male; Sheep; Tandem Mass Spectrometry	2014
Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep: pharmacokinetic support to its excellent nematodicidal activity. Veterinary parasitology, 2014, Jun-16, Volume: 203, Issue:1-2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Gastrointestinal Contents; Liver; Nematoda; Nematode Infections; Sheep; Sheep Diseases; Sulfones	2014
Monepantel: the most studied new anthelmintic drug of recent years. Parasitology, 2014, Volume: 141, Issue:13 Topics: Aminoacetonitrile; Animals; Anthelmintics; Feces; Larva; Nematoda; Nematode Infections; Sheep; Sheep Diseases	2014
Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors. Molecular pharmacology, 2015, Volume: 87, Issue:1 Topics: Aminoacetonitrile; Animals; Anthelmintics; Betaine; Caenorhabditis elegans; Choline; Drug Synergism; Haemonchus; Helminth Proteins; Ligand-Gated Ion Channels; Membrane Potentials; Receptors, Nicotinic; Xenopus laevis	2015
Monepantel resistance reported on Dutch sheep farms. The Veterinary record, 2014, Nov-01, Volume: 175, Issue:17 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Nematoda; Nematode Infections; Netherlands; Sheep; Sheep Diseases	2014
First report of monepantel Haemonchus contortus resistance on sheep farms in Uruguay. Parasites & vectors, 2014, Dec-17, Volume: 7 Topics: Aminoacetonitrile; Animal Husbandry; Animals; Anthelmintics; Feces; Gastrointestinal Diseases; Haemonchiasis; Haemonchus; Male; Parasite Egg Count; Random Allocation; Sheep; Sheep Diseases; Uruguay	2014
Monepantel induces hepatic cytochromes p450 in sheep in vitro and in vivo. Chemico-biological interactions, 2015, Feb-05, Volume: 227 Topics: Aminoacetonitrile; Animals; Cells, Cultured; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Hepatocytes; Liver; Protein Isoforms; RNA, Messenger; Sheep	2015
Haemonchus contortus resistance to monepantel in sheep. Veterinary parasitology, 2015, Apr-30, Volume: 209, Issue:3-4 Topics: Aminoacetonitrile; Animals; Drug Resistance; Haemonchiasis; Haemonchus; Sheep; Sheep Diseases	2015
Comparison of biotransformation and efficacy of aminoacetonitrile anthelmintics in vitro. Drug testing and analysis, 2016, Volume: 8, Issue:2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Biotransformation; Cells, Cultured; Chromatography, High Pressure Liquid; Haemonchus; Hepatocytes; Larva; Mebendazole; Rats; Rats, Wistar; Sheep; Tandem Mass Spectrometry; Thiabendazole	2016
Selection and characterisation of monepantel resistance in Teladorsagia circumcincta isolates. International journal for parasitology. Drugs and drug resistance, 2015, Volume: 5, Issue:2 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Feces; Female; Male; Nematoda; Parasite Egg Count; Selection, Genetic; Sheep; Sheep Diseases	2015
Lack of efficacy of monepantel against Trichostrongylus colubriformis in sheep in Brazil. Veterinary parasitology, 2016, Jan-30, Volume: 216 Topics: Abomasum; Administration, Oral; Aminoacetonitrile; Animals; Antinematodal Agents; Brazil; Drug Resistance; Feces; Female; Haemonchus; Intestines; Male; Oesophagostomum; Sheep; Sheep Diseases; Trichostrongyloidea; Trichostrongylosis; Trichostrongylus	2016
Hepatic biotransformation pathways and ruminal metabolic stability of the novel anthelmintic monepantel in sheep and cattle. Journal of veterinary pharmacology and therapeutics, 2016, Volume: 39, Issue:5 Topics: Aminoacetonitrile; Animals; Anthelmintics; Biotransformation; Cattle; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Flavins; Liver; Male; Methimazole; Mixed Function Oxygenases; Piperonyl Butoxide; Rumen; Sheep	2016
Larval development assays reveal the presence of sub-populations showing high- and low-level resistance in a monepantel (Zolvix®)-resistant isolate of Haemonchus contortus. Veterinary parasitology, 2016, Apr-15, Volume: 220 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Haemonchus; In Vitro Techniques; Inhibitory Concentration 50; Ivermectin; Larva; Zygote	2016
Phenotypic assessment of the ovicidal activity of monepantel and monepantel sulfone on gastro-intestinal nematode eggs. Veterinary parasitology, 2016, Apr-15, Volume: 220 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Embryo, Nonmammalian; Haemonchus; Inhibitory Concentration 50; Phenotype; Sulfones; Trichostrongylus; Zygote	2016
Selenophene and thiophene-core estrogen receptor ligands that inhibit motility and development of parasitic stages of Haemonchus contortus. Parasites & vectors, 2016, 06-16, Volume: 9, Issue:1 Topics: Aminoacetonitrile; Animals; Antiparasitic Agents; Haemonchus; Macrolides; Molecular Structure; Organoselenium Compounds; Phenols; Receptors, Estrogen; Structure-Activity Relationship; Sulfur Compounds; Thiophenes	2016
Resistance of Haemonchus sp. to monepantel and reduced efficacy of a derquantel / abamectin combination confirmed in sheep in NSW, Australia. Veterinary parasitology, 2016, Sep-15, Volume: 228 Topics: Albendazole; Aminoacetonitrile; Animals; Anthelmintics; Australia; Drug Therapy, Combination; Feces; Haemonchiasis; Haemonchus; Indoles; Ivermectin; Macrolides; Male; Oxepins; Parasite Egg Count; Random Allocation; Salicylanilides; Sheep; Sheep Diseases; Treatment Failure	2016
Organometallic Derivatization of the Nematocidal Drug Monepantel Leads to Promising Antiparasitic Drug Candidates. Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Nov-07, Volume: 22, Issue:46 Topics: Aminoacetonitrile; Animals; Antinematodal Agents; Antiparasitic Agents; Crystallography, X-Ray; Drug Resistance; Haemonchus	2016
Reclassification of monepantel. The Veterinary record, 2017, 04-01, Volume: 180, Issue:13 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Sheep; Sheep Diseases; United Kingdom; Veterinary Medicine	2017
Reclassification of monepantel. The Veterinary record, 2017, 04-08, Volume: 180, Issue:14 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Parasitic Diseases, Animal; Sheep; Sheep Diseases; United Kingdom; Veterinary Medicine	2017
Response of drug-susceptible and -resistant Haemonchus contortus larvae to monepantel and abamectin alone or in combination in vitro. Veterinary parasitology, 2018, Jan-15, Volume: 249 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Combinations; Drug Resistance; Haemonchiasis; Haemonchus; Ivermectin; Larva; Sheep; Sheep Diseases	2018
Supplementation with dry Mimosa caesalpiniifolia leaves can reduce the Haemonchus contortus worm burden of goats. Veterinary parasitology, 2018, Mar-15, Volume: 252 Topics: Aminoacetonitrile; Animal Feed; Animals; Anthelmintics; Brazil; Dietary Supplements; Feces; Gastrointestinal Tract; Goat Diseases; Goats; Haemonchiasis; Haemonchus; Mimosa; Parasite Egg Count; Plant Leaves; Proanthocyanidins	2018
Lack of efficacy of monepantel against trichostrongyle nematodes in a UK sheep flock. Veterinary parasitology, 2018, Jun-15, Volume: 257 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Female; Male; Oesophagostomiasis; Oesophagostomum; Parasite Egg Count; Sheep; Sheep Diseases; Trichostrongylosis; Trichostrongylus; United Kingdom	2018
Alarming levels of anthelmintic resistance against gastrointestinal nematodes in sheep in the Netherlands. Veterinary parasitology, 2018, Oct-15, Volume: 262 Topics: Aminoacetonitrile; Animals; Anthelmintics; Benzimidazoles; Drug Resistance; Feces; Haemonchiasis; Haemonchus; Intestinal Diseases, Parasitic; Ivermectin; Levamisole; Macrolides; Parasite Egg Count; Salicylanilides; Sheep; Sheep Diseases	2018
The intake of dry cashew apple fiber reduced fecal egg counts in Haemonchus contortus-infected sheep. Experimental parasitology, 2018, Volume: 195 Topics: Aminoacetonitrile; Anacardium; Animals; Anthelmintics; Dietary Fiber; Drug Resistance; Feces; Flavonoids; Gas Chromatography-Mass Spectrometry; Haemonchiasis; Haemonchus; Male; Parasite Egg Count; Phytotherapy; Polyphenols; Sheep; Sheep Diseases; Silage; Weight Gain; Zea mays	2018
Journal of helminthology, 2019, Mar-18, Volume: 94 Topics: Aminoacetonitrile; Animals; Anthelmintics; Dose-Response Relationship, Drug; Drug Resistance; Female; Haemonchiasis; Haemonchus; Male; Parasite Egg Count; Sheep; Sheep Diseases	2019
Monepantel resistant Trichostrongylus colubriformis in goats in Brazil. Veterinary parasitology, regional studies and reports, 2018, Volume: 11 Topics: Aminoacetonitrile; Animals; Anthelmintics; Brazil; Drug Resistance; Feces; Goat Diseases; Goats; Haemonchus; Parasite Egg Count; Sheep; Trichostrongylosis; Trichostrongylus	2018
Current anthelmintic treatment is not always effective at controlling strongylid infections in German alpaca herds. Parasites & vectors, 2019, Jul-02, Volume: 12, Issue:1 Topics: Aminoacetonitrile; Animals; Anthelmintics; Camelids, New World; Feces; Female; Fenbendazole; Haemonchus; Helminthiasis, Animal; Intestinal Diseases, Parasitic; Macrolides; Male; Parasite Egg Count; Strongylida; Strongylida Infections	2019
The uptake, effects and biotransformation of monepantel in meadow plants used as a livestock feed. Chemosphere, 2019, Volume: 237 Topics: Aminoacetonitrile; Animal Feed; Animals; Anthelmintics; Biological Transport; Biotransformation; Environmental Pollution; Grassland; Livestock; Medicago sativa; Metabolic Networks and Pathways; Plantago; Sulfones; Tandem Mass Spectrometry	2019
Extreme-QTL mapping of monepantel resistance in Haemonchus contortus. Parasites & vectors, 2019, Aug-14, Volume: 12, Issue:1 Topics: Aminoacetonitrile; Animals; Anthelmintics; Drug Resistance; Female; Genetic Variation; Haemonchus; Male; Mutation; Phenotype; Quantitative Trait Loci	2019
Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta. International journal for parasitology. Drugs and drug resistance, 2019, Volume: 11 Topics: Aminoacetonitrile; Animals; Anthelmintics; DNA, Helminth; Drug Resistance; Genotype; High-Throughput Nucleotide Sequencing; Loss of Function Mutation; Male; Microsatellite Repeats; Scotland; Sequence Alignment; Sheep; Sheep Diseases; Trichostrongyloidea; Trichostrongyloidiasis; United Kingdom	2019
Carvacrol acts as a potent selective antagonist of different types of nicotinic acetylcholine receptors and enhances the effect of monepantel in the parasitic nematode Ascaris suum. Veterinary parasitology, 2020, Volume: 278 Topics: Aminoacetonitrile; Animals; Antinematodal Agents; Ascaris suum; Central Nervous System; Cymenes; Diaphragm; Female; Muscles; Nicotinic Agonists; Nicotinic Antagonists; Rats	2020
First case of monepantel resistant nematodes of sheep in Sweden. Veterinary parasitology, regional studies and reports, 2020, Volume: 22 Topics: Aminoacetonitrile; Animals; Drug Resistance; Feces; Female; Nematoda; Nematode Infections; Parasite Egg Count; Sheep; Sheep Diseases; Sweden	2020
Nemabiome metabarcoding reveals differences between gastrointestinal nematode species infecting co-grazed sheep and goats. Veterinary parasitology, 2021, Volume: 289 Topics: Aminoacetonitrile; Animals; Anthelmintics; DNA Barcoding, Taxonomic; Feces; Female; Genomics; Goat Diseases; Goats; Male; Nematoda; Nematode Infections; Parasite Egg Count; Polymerase Chain Reaction; Sheep; Sheep Diseases	2021
Resistance of Haemonchus contortus to monepantel in sheep: first report in Espírito Santo, Brazil. Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria, 2021, Volume: 30, Issue:4 Topics: Aminoacetonitrile; Animals; Anthelmintics; Brazil; Drug Resistance; Feces; Female; Haemonchiasis; Haemonchus; Male; Parasite Egg Count; Sheep; Sheep Diseases	2021