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amiloride and 5-(n,n-hexamethylene)amiloride

amiloride has been researched along with 5-(n,n-hexamethylene)amiloride in 119 studies

Research

Studies (119)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (4.20)	18.7374
1990's	62 (52.10)	18.2507
2000's	28 (23.53)	29.6817
2010's	16 (13.45)	24.3611
2020's	8 (6.72)	2.80

Authors

Authors	Studies
Bilodeau, MT; Bock, MG; Cato, MJ; Chang, RK; Cook, SP; Di Marco, CN; Dipardo, RM; Hartman, GD; Jovanovska, A; Kane, SA; Kuduk, SD; Leitl, M; Spencer, RH; Urban, MO	1
Adlere, I; Buckley, BJ; Dijksteel, GS; Guo, D; Huisman, BJ; IJzerman, AP; Kelso, M; Lenselink, EB; Louvel, J; Massink, A; Matthews, H; Ranson, M; van Veen, C	1
Aboelela, A; Ali, U; Apte, M; Bachovchin, DA; Buckley, BJ; Cheung, CY; Cook, GM; Cook, SM; Fildes, K; Huang, M; Jiang, LX; Johnson, DC; Kelso, MJ; Minaei, E; Ranson, M; Xu, Z	1
Aboelela, A; Buckley, BJ; Bujaroski, RS; Charman, SA; Cook, GM; Katneni, K; Kelso, MJ; Majed, H; Powell, AK; Ranson, M; Saunders, J; Shackleford, DM; Wang, W; White, KL	1
Buckley, BJ; Huang, M; Jiang, L; Kelso, MJ; Ranson, M; S El Salamouni, N; Yu, H	1
Horiguchi, M; Kuriyama, S; Nakamura, K; Sakai, O; Uchida, H	1
Cheng, B; Roos, A; Wilding, TJ	1
Cocks, BG; Cragoe, EJ; Hamilton, JA; Vairo, G	1
Brørs, O; Cragoe, EJ; Holthe, MR; Raeder, M; Veel, T	1
Cragoe, EJ; Holthe, MR; Raeder, MG; Veel, T; Villanger, O	1
Anagnostopoulos, T; Terzic, A; Vogel, SM	1
Ingber, DE; Lechene, C; Schwartz, MA	1
Cragoe, EJ; Garritsen, A; Ijzerman, AP; Soudijn, W; Tulp, MT	1
Andersson, RG; Cragoe, EJ; Grundström, N; Karlsson, JO; Mårtensson, LG; Svensson, SP	1
Battistini, B; Cragoe, EJ; Filep, JG; Fournier, A; Sirois, P	1
Cragoe, EJ; Hori, M; Iwakura, K; Kamada, T; Kitabatake, A; Watanabe, Y; Yoshida, H	1
Coetzee, WA; Cragoe, EJ; Dennis, SC; Opie, LH	1
Heagerty, AM; Izzard, AS	1
Chik, CL; Cragoe, EJ; Ho, AK; Lalh, SS; Young, I	1
Etscheid, BG; Jamieson, GA; Toscas, K; Villereal, ML	1
Cragoe, EJ; Goldsmith, DJ; Hilton, PJ; Morris, J; Poston, L; Watson, M	1
Cragoe, EJ; Jamieson, GP; Jopson, M; Mayger, W; Wiley, JS	1
Cragoe, EJ; Gerritsen, ME; Medow, MS; Moatter, T; Perry, CA	1
Cragoe, EJ; Donoso, VS; Grantham, JA; Grantham, JJ	1
Cragoe, EJ; Goldsmith, DJ; Hilton, PJ; Poston, L; Richards, NT	1
Cragoe, EJ; Cubeddu, LX; Zubieta, JK	1
Brum, JM; Cragoe, EJ; Ferrario, CM; Reynolds, EE	1
Cittadini, A; Di Francesco, A; Wolf, FI	1
Cragoe, EJ; Hotokebuchi, N; Lai, ZF; Nishi, K	1
Cáceres-Cortés, J; Dumouchel, J; Haddad, P; Hoang, T; Rajotte, D	1
Dubyak, GR; Nuttle, LC	1
Chen, JR; Jamieson, GP; Wiley, JS	1
Cohn, RC; Rudzienski, L	1
Schiffrin, EL; Touyz, RM	1
Haist, JV; Karmazyn, M; Ray, M	1
Baron, R; Boron, WF; Eisen, T; Ravesloot, JH	1
Li, L; van Breemen, C	1
Carr, P; McKinnon, W; Poston, L	1
Hayashi, H; Katoh, H; Kobayashi, A; Satoh, H; Terada, H	1
Luo, J; Tannock, IF	1
Hashimoto, T; Kuriyama, S; Matsui, K; Sakai, O; Tokudome, G; Tomonari, H; Utsunomiya, Y	1
Cragoe, EJ; Griffin, RJ; Kim, GE; Lyons, JC; Makepeace, CM; Rao, GH; Song, CW	1
Chen, YF; Cragoe, EJ; Meng, QC; Oparil, S; Yang, RH	1
Hayashi, H; Katoh, H; Nakamura, T; Satoh, H; Terada, H	1
Cragoe, EJ; Griffin, RJ; Lyons, JC; Makepeace, CM; Song, CW	2
Cragoe Júnior, EJ; Dantas, WF; de Lira, RF; Fernandez, R; Lopes, MJ; Malnic, G	1
Hayashi, H; Hirano, M; Kobayashi, A; Noda, N; Satoh, H; Terada, H; Yamashita, Y; Yamazaki, N	1
Ajao, P; Baldwin, DR; Cragoe, EJ; Knox, AJ	1
Karmazyn, M	1
de Moraes, VL	1
Radda, GK; Schussheim, AE	1
Hayashi, H; Katoh, H; Noda, N; Ohno, R; Satoh, H; Terada, H; Yamazaki, N	1
Kasama, M; Mashima, S; Tsutsumi, T	1
Andrews, PA; Kennedy, KA; Laurencot, CM	1
Kennedy, KA; Laurencot, CM	1
Bateman, NT; Neville, E; Ward, JP	1
Amoroso, S; Annunziato, L; Bassi, A; Cataldi, M; Colao, AM; Di Renzo, G; Fatatis, A; Lombardi, G	1
Chi, Y; Mo, S; Mota de Freitas, D	1
Malnic, G; Rebouças, NA	1
Barreto-Chaves, ML; Mello-Aires, M	1
Chessell, IP; Humphrey, PP; Michel, AD	1
Barreto-Chaves, ML; de Mello-Aires, M	1
Dubé, F; Eckberg, WR	1
Beauwens, R; Braekman, JC; Daloze, D; Golstein, PE; Van Sande, J; Vroye, L	1
Baud, L; Bellocq, A; Bertrand, F; Cherqui, G; Fouqueray, B; Perez, J; Philippe, C; Suberville, S	1
de Ribaupierre, Y; Kucera, P; Meiltz, A; Raddatz, E	1
Nakajima, N; Nakaya, H; Tamagawa, M; Yamaguchi, S	1
Friis, UG; Jensen, TB; Johansen, T	1
Hayashi, H; Kaneko, M; Katoh, H; Nakamura, T; Satoh, H; Terada, H	1
Cobo, JM; Díaz-Gil, JJ; García-Cañero, R; Pérez de Diego, J; Trilla, C	1
Fernandez, R; Malnic, G; Ramirez, M	1
Garden, OA; Musk, P; Rich, IN; Worthington-White, D	1
Fliegel, L; Moor, AN; Murtazina, R	1
Gao, ZG; Ijzerman, AP	1
Malnic, G; Parisi, M; Ramirez, MA; Toriano, R	1
Chik, CL; Ho, AK; Ling, A	1
Hibell, AD; Humphrey, PP; Michel, AD; Thompson, KM; Xing, M	1
Davis, MJ; Wu, X	1
Ago, T; Fujishima, M; Ibayashi, S; Kamouchi, M; Kitazono, T; Nakamura, H; Ooboshi, H	1
Haddad, JJ; Land, SC	1
Cox, GB; Ewart, GD; Gage, PW; Mills, K	1
Amano, H; Ohya, K; Shibata, T; Yamada, S	1
Aksenov, ND; Kharchenko, MV; Kornilova, ES	1
Ago, T; Ibayashi, S; Iida, M; Kamouchi, M; Kitazono, T; Ooboshi, H; Santa, N; Wakisaka, M	1
Altairac, S; Courtois, Y; Perani, P; Torriglia, A; Zeggai, S	1
Ewart, GD; Gage, PW; Premkumar, A; Wilson, L	1
Cox, GB; Cunningham, AL; Ewart, GD; Gage, PW; Naif, H; Nasr, N	1
Goto, T; Hongo, K; Horiuchi, T; Saesue, P; Tanaka, Y	1
Suzuki, T; Tsukamoto, I	1
Gage, PW; Horan, CR; Premkumar, A	1
Mello-Aires, M; Musa-Aziz, R; Oliveira-Souza, M	1
Ewart, G; Gage, P; Wilson, L	1
Lachapelle, G; Mosser, DD; Radicioni, SM; Stankiewicz, AR	1
Hagiwara, N; Ibayashi, S; Iida, M; Ishikawa, E; Kamouchi, M; Kitazono, T; Kuroda, J; Matsuo, R; Nakamura, K; Ooboshi, H	1
Kasaba, T; Onizuka, S; Takasaki, M; Tamura, R	1
Arreola, J; Kaba, NK; Kim, M; Knauf, PA; Law, FY; Lefort, CT; Martel-Gallegos, G; Schultz, J; Waugh, RE	1
Demaurex, N; Park, KS; Poburko, D; Wollheim, CB	1
Jiang, FL; Lin, X; Liu, DX; Parthasarathy, K; Pervushin, K; Soong, TW; Tan, E; Torres, J; Vararattanavech, A; Yu, D	1
D'Amico, M; Martire, M; Samengo, I	1
Böckmann, A; Chipot, C; Dubuisson, J; Ebel, C; Montserret, R; Penin, F; Pietschmann, T; Renisio, JG; Saint, N; Salvay, AG; Sapay, N; Simorre, JP; Steinmann, E; Vanbelle, C	1
Del Duca, O; Donini, A; Galperin, V; Nasirian, A	1
Aredia, F; Bottiroli, G; Croce, AC; Giansanti, V; Santamaria, G; Scovassi, AI; Torriglia, A	1
Forlino, A; Giansanti, V; Gioia, R; Mazzini, G; Pennati, M; Rodriguez, GE; Savoldelli, M; Scovassi, AI; Torriglia, A; Zaffaroni, N	1
Aravena, C; Beltrán, AR; Cornejo, M; Díaz, ES; Guzmán-Gutiérrez, E; Leiva, A; Pardo, F; Ramírez, MA; Sobrevia, L; Torres, V	1
Aredia, F; Forlino, A; Giansanti, V; Jaadane, I; Mazzini, G; Ortiz, LM; Savio, M; Scovassi, AI; Torriglia, A; Zaffaroni, N	1
Cherezov, V; Gutiérrez-de-Terán, H; Han, GW; Heitman, LH; Ijzerman, AP; Joseph, JS; Katritch, I; Katritch, V; Liu, W; Massink, A; Rodríguez, D; Stevens, RC; Xia, L	1
Doki, T; Hohdatsu, T; Nakano, K; Takano, T	1
Berg, AL; Carraway, KL; Curiel, DA; Hatakeyama, J; Leon, LJ; Rowson-Hodel, AR; Sweeney, C; VanderVorst, K; Wald, JH	1
Chou, JJ; Dev, J; Du, L; Liu, Z; OuYang, B; Wang, S; Zhao, L; Zhou, L	1
Chou, D; Eldstrom, J; Fedida, D; Jalily, PH; Kwan, DC; Miller, SC; Niikura, M; Tai, SS; Tietjen, I	1
Gonzales, EB; Snell, HD	1
Aredia, F; Czaplinski, S; Fulda, S; Scovassi, AI	1
Dregni, AJ; Hong, M; Kolocouris, A; Mandala, VS; McKay, MJ; Shcherbakov, AA	1
B Andreas, L; Becker, S; Bentzen, BH; Giller, K; Jeppesen, MG; Kledal, TN; Kolocouris, A; Mujezinovic, A; Rosenkilde, MM; Toft-Bertelsen, TL; Tzortzini, E; Xue, K	1
Aboelela, A; Al-Rifai, D; Buckley, BJ; Bujaroski, RS; Cuthbertson, P; Elhage, A; Jalilian, I; Kelso, MJ; Majed, H; Sluyter, R; Sophocleous, RA; Turner, RJ; Watson, D	1
Fedida, D; Jalily Hasani, H; Jalily, PH	1
Aboelela, A; Adams, DJ; Buckley, BJ; Bujaroski, RS; Finol-Urdaneta, RK; Kelso, MJ; Majed, H; McArthur, JR; Rangel, A; Ranson, M	1
DeGrado, WF; Hong, M; Jo, H; Medeiros-Silva, J; Somberg, NH; Wang, J	1

Other Studies

119 other study(ies) available for amiloride and 5-(n,n-hexamethylene)amiloride

Article	Year
Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3). Bioorganic & medicinal chemistry letters, 2009, May-01, Volume: 19, Issue:9 Topics: Acid Sensing Ion Channels; Acidosis; Amiloride; Amines; Animals; Chemistry, Pharmaceutical; Drug Design; Electrophysiology; Inhibitory Concentration 50; Male; Models, Chemical; Nerve Tissue Proteins; Pain; Pyrazines; Rats; Rats, Sprague-Dawley; Sodium Channels	2009
5'-Substituted Amiloride Derivatives as Allosteric Modulators Binding in the Sodium Ion Pocket of the Adenosine A2A Receptor. Journal of medicinal chemistry, 2016, 05-26, Volume: 59, Issue:10 Topics: Adenosine A2 Receptor Antagonists; Allosteric Regulation; Allosteric Site; Amiloride; Humans; Molecular Docking Simulation; Molecular Structure; Receptor, Adenosine A2A; Structure-Activity Relationship	2016
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. Journal of medicinal chemistry, 2018, 09-27, Volume: 61, Issue:18 Topics: Amiloride; Animals; Antineoplastic Agents; Cell Movement; Cell Proliferation; Crystallography, X-Ray; Diuresis; Diuretics; Drug Discovery; Female; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Models, Molecular; Molecular Structure; Pancreatic Neoplasms; Potassium; Protein Conformation; Sodium; Structure-Activity Relationship; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator; Xenograft Model Antitumor Assays	2018
Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride. Bioorganic & medicinal chemistry, 2021, 05-01, Volume: 37 Topics: Amiloride; Animals; Antineoplastic Agents; Caco-2 Cells; Drug Screening Assays, Antitumor; Female; Humans; Male; Mice, Inbred BALB C; Microsomes, Liver; Molecular Structure; Rats, Sprague-Dawley; Structure-Activity Relationship	2021
Disruption of Water Networks is the Cause of Human/Mouse Species Selectivity in Urokinase Plasminogen Activator (uPA) Inhibitors Derived from Hexamethylene Amiloride (HMA). Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3 Topics: Amiloride; Animals; Enzyme Inhibitors; Humans; Mice; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Structure; Mutation; Protein Binding; Species Specificity; Thermodynamics; Urokinase-Type Plasminogen Activator; Water	2022
Decreased insulin-sensitive Ca2+ transport in cultured vascular smooth muscle cells from spontaneously hypertensive rats. American journal of hypertension, 1992, Volume: 5, Issue:12 Pt 1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Biological Transport; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cells, Cultured; Diltiazem; Gallic Acid; Homeostasis; Hypertension; Insulin; Isoquinolines; Male; Muscle, Smooth, Vascular; Piperazines; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY	1992
pH regulation in adult rat carotid body glomus cells. Importance of extracellular pH, sodium, and potassium. The Journal of general physiology, 1992, Volume: 100, Issue:4 Topics: Acid-Base Equilibrium; Amiloride; Ammonium Chloride; Animals; Buffers; Carbon Dioxide; Carotid Body; Cell Hypoxia; Hydrogen-Ion Concentration; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Spectrophotometry, Ultraviolet; Temperature	1992
Selective suppression of growth factor-induced cell cycle gene expression by Na+/H+ antiport inhibitors. The Journal of biological chemistry, 1992, Sep-25, Volume: 267, Issue:27 Topics: Amiloride; Animals; Carrier Proteins; Cell Cycle; Cells, Cultured; Cyclins; DNA; DNA Replication; Gene Expression; In Vitro Techniques; Macrophage Colony-Stimulating Factor; Macrophages; Mice; Mice, Inbred Strains; Nuclear Proteins; Proliferating Cell Nuclear Antigen; RNA; RNA, Messenger; Sodium-Hydrogen Exchangers	1992
Determination of active 5-(N,N-hexamethylene)amiloride in pig plasma. Journal of chromatography, 1992, Sep-02, Volume: 579, Issue:2 Topics: Amiloride; Animals; Chromatography, Thin Layer; Densitometry; Swine	1992
Secretin stimulates bile ductules to secrete both H+ and HCO3(-)-ions. Acta physiologica Scandinavica, 1992, Volume: 146, Issue:3 Topics: Amiloride; Animals; Bicarbonates; Bile Ducts; Cytoplasm; Epithelium; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Exchange; Liver; Secretin; Stimulation, Chemical; Swine	1992
Opposite modulation of ouabain cardiotoxicity by hexamethyleneamiloride and phenylephrine. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:5 Topics: Amiloride; Animals; Antiporters; Carrier Proteins; Hydrogen-Ion Concentration; In Vitro Techniques; Membrane Potentials; Microelectrodes; Myocardial Contraction; Ouabain; Phenylephrine; Rats; Rats, Inbred Strains; Sodium Channels	1991
Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proceedings of the National Academy of Sciences of the United States of America, 1991, Sep-01, Volume: 88, Issue:17 Topics: Amiloride; Animals; Carrier Proteins; Cell Adhesion; Cell Line; Fibronectins; Humans; Hydrogen-Ion Concentration; Integrins; Kinetics; Mice; Mice, Inbred C3H; Sodium-Hydrogen Exchangers	1991
Receptor binding profiles of amiloride analogues provide no evidence for a link between receptors and the Na+/H+ exchanger, but indicate a common structure on receptor proteins. Journal of receptor research, 1991, Volume: 11, Issue:6 Topics: Amiloride; Animals; Binding Sites; GTP-Binding Proteins; Rats; Receptors, Cell Surface; Sodium; Structure-Activity Relationship	1991
Antagonistic effect of amiloride on alpha-2 adrenoceptor-mediated pigment aggregation: pharmacological heterogeneity between B-HT 920 and noradrenaline. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 258, Issue:2 Topics: Adrenergic alpha-Agonists; Amiloride; Animals; Azepines; Cyclic AMP; Fishes; Norepinephrine; Pigments, Biological; Receptors, Adrenergic, alpha; Sodium	1991
A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro. Biochemical and biophysical research communications, 1991, Mar-15, Volume: 175, Issue:2 Topics: Amiloride; Animals; Biological Transport; Bronchoconstriction; Carrier Proteins; Dose-Response Relationship, Drug; Endothelins; Guinea Pigs; Hydrogen-Ion Concentration; In Vitro Techniques; Sodium; Sodium-Hydrogen Exchangers	1991
Alpha 1-adrenoceptor stimulation increases intracellular pH and Ca2+ in cardiomyocytes through Na+/H+ and Na+/Ca2+ exchange. European journal of pharmacology, 1990, Sep-04, Volume: 186, Issue:1 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-Agonists; Amiloride; Animals; Calcium; Fluorescent Dyes; Heart; Hydrogen; Hydrogen-Ion Concentration; Ion Exchange; Isoquinolines; Male; Myocardium; Norepinephrine; Phentolamine; Piperazines; Prazosin; Propranolol; Protein Kinase Inhibitors; Rats; Rats, Inbred Strains; Sodium; Yohimbine	1990
Effects of proton buffering and of amiloride derivatives on reperfusion arrhythmias in isolated rat hearts. Possible evidence for an arrhythmogenic role of Na(+)-H+ exchange. Circulation research, 1990, Volume: 66, Issue:4 Topics: Amiloride; Animals; Arrhythmias, Cardiac; Buffers; Carrier Proteins; HEPES; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Piperazines; Protons; Rats; Rats, Inbred Strains; Sodium-Hydrogen Exchangers	1990
Endothelin-induced contraction of human peripheral resistance vessels is partly dependent on stimulation of sodium-hydrogen exchange. Journal of hypertension, 1990, Volume: 8, Issue:4 Topics: Amiloride; Animals; Endothelins; Humans; In Vitro Techniques; Ion Exchange; Peptides; Rats; Sodium; Vascular Resistance; Vasoconstriction	1990
Inhibitory effects of amilorides on pinealocyte adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate accumulation: possible involvement of postreceptor mechanisms. Endocrinology, 1990, Volume: 127, Issue:1 Topics: Amiloride; Animals; Carrier Proteins; Cyclic AMP; Cyclic GMP; Drug Synergism; Hydrogen-Ion Concentration; Isoproterenol; Male; Norepinephrine; Phenylephrine; Pineal Gland; Potassium; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate	1990
Loss of bradykinin receptors and TPA-stimulated Na+ influx in SV40-transformed WI-38 cells. The American journal of physiology, 1990, Volume: 259, Issue:4 Pt 1 Topics: Amiloride; Bradykinin; Cell Division; Cell Line; Cell Transformation, Neoplastic; Growth Substances; Humans; Inositol Phosphates; Kinetics; Receptors, Bradykinin; Receptors, Neurotransmitter; Simian virus 40; Sodium; Tetradecanoylphorbol Acetate	1990
Effect of autologous serum on human leucocyte Na+/H+ exchange and intracellular pH. Clinical science (London, England : 1979), 1990, Volume: 79, Issue:4 Topics: Amiloride; Ammonium Chloride; Blood; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Ion Exchange; Leukocytes; Sodium	1990
Extracellular ATP stimulates an amiloride-sensitive sodium influx in human lymphocytes. Archives of biochemistry and biophysics, 1990, Aug-01, Volume: 280, Issue:2 Topics: Adenosine Triphosphate; Amiloride; Biological Transport; Dose-Response Relationship, Drug; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Membrane Potentials; Sodium; Thymine Nucleotides; Uridine Triphosphate	1990
Agonist-specific role for Na+-H+ antiport in prostaglandin release from microvessel endothelium. The American journal of physiology, 1989, Volume: 256, Issue:4 Pt 1 Topics: Adenosine Triphosphate; Amiloride; Animals; Biological Transport; Calcimycin; Carrier Proteins; Cells, Cultured; Coronary Vessels; Dinoprostone; Endothelium, Vascular; Epoprostenol; Fluoresceins; Fluorescent Dyes; Hydrogen-Ion Concentration; Microcirculation; Prostaglandins; Protons; Rabbits; Sodium; Sodium-Hydrogen Exchangers; Thrombin	1989
Effect of amiloride on the compensatory renal growth that follows uninephrectomy in mice. The Journal of laboratory and clinical medicine, 1989, Volume: 114, Issue:2 Topics: Amiloride; Animals; Biological Transport; Carrier Proteins; Female; Kidney; Male; Mice; Nephrectomy; Organ Size; Potassium; Proteins; Sodium; Sodium-Hydrogen Exchangers; Spironolactone	1989
Endothelin-induced contraction of human peripheral resistance vessels is partly dependent on stimulation of sodium-hydrogen exchange. Journal of hypertension, 1989, Volume: 7, Issue:10 Topics: Amiloride; Carrier Proteins; Dose-Response Relationship, Drug; Endothelins; Endothelium, Vascular; Humans; Leukocytes; Muscle Contraction; Muscle, Smooth, Vascular; Peptides; Sodium-Hydrogen Exchangers; Vascular Resistance	1989
Effects of amiloride and 5-(N,N-hexamethylene)amiloride on dopaminergic and cholinergic neurotransmission. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:1 Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Amiloride; Animals; Apomorphine; Carrier Proteins; Dopamine; Electric Stimulation; In Vitro Techniques; Monoamine Oxidase Inhibitors; Nomifensine; Pargyline; Rabbits; Sodium-Hydrogen Exchangers; Synaptic Transmission	1988
Effect of Na+/H+ exchange inhibitors on agonist-induced contraction of rat aorta. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Amiloride; Animals; Aorta; Calcium; Carrier Proteins; Male; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred Strains; Sodium-Hydrogen Exchangers; Vasoconstriction	1988
Characterization of magnesium efflux from Ehrlich ascites tumor cells. Archives of biochemistry and biophysics, 1994, Feb-01, Volume: 308, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Amiloride; Animals; Antimycin A; Bucladesine; Bumetanide; Calcimycin; Carcinoma, Ehrlich Tumor; Colforsin; Cyclic AMP; Energy Metabolism; Glucose; Homeostasis; Imipramine; Kinetics; Magnesium; Mice; Ouabain; Quinidine; Rotenone; Time Factors; Tumor Cells, Cultured	1994
Effects of 5-(N,N-hexamethylene)amiloride on action potentials, intracellular Na, and pH of guinea pig ventricular muscle in vitro. Journal of cardiovascular pharmacology, 1994, Volume: 23, Issue:2 Topics: Acidosis; Action Potentials; Amiloride; Ammonium Chloride; Animals; Female; Guinea Pigs; Heart; Heart Ventricles; Hydrogen-Ion Concentration; In Vitro Techniques; Ion-Selective Electrodes; Kinetics; Male; Microelectrodes; Myocardium; Papillary Muscles; Sodium	1994
Product of the steel locus suppresses apoptosis in hemopoietic cells. Comparison with pathways activated by granulocyte macrophage colony-stimulating factor. The Journal of biological chemistry, 1994, Apr-22, Volume: 269, Issue:16 Topics: Alkaloids; Amiloride; Animals; Apoptosis; Bone Marrow; Bone Marrow Cells; Catechols; Cell Division; Cell Line; Cell Survival; DNA; DNA Damage; Fusion Proteins, bcr-abl; Granulocyte-Macrophage Colony-Stimulating Factor; Hematopoietic Cell Growth Factors; Hematopoietic Stem Cells; Humans; Hydrogen-Ion Concentration; Interleukin-3; Leukemia, Myeloid, Acute; Nitriles; Protein Kinase Inhibitors; Recombinant Proteins; Staurosporine; Stem Cell Factor; Thymidine; Transfection; Tyrphostins	1994
Differential activation of cation channels and non-selective pores by macrophage P2z purinergic receptors expressed in Xenopus oocytes. The Journal of biological chemistry, 1994, May-13, Volume: 269, Issue:19 Topics: Adenosine Triphosphate; Amiloride; Animals; Cations; Cell Line; Female; Ion Channels; Macrophages; Mice; Oocytes; Receptors, Purinergic; Recombinant Proteins; RNA, Messenger; Temperature; Xenopus laevis	1994
Extracellular ATP increases NH4+ permeability in human lymphocytes by opening a P2Z purinoceptor operated ion channel. Biochemical and biophysical research communications, 1994, Aug-15, Volume: 202, Issue:3 Topics: Adenosine Triphosphate; Amiloride; Amines; Biological Transport; Calcium; Cell Membrane Permeability; Fluoresceins; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Ion Channels; Lymphocytes; Oxidation-Reduction; Quaternary Ammonium Compounds; Receptors, Purinergic	1994
In vitro suppression of Pseudomonas cepacia after limited exposure to subinhibitory concentrations of amiloride and 5-(N,N-hexamethylene) amiloride. Pediatric pulmonology, 1994, Volume: 17, Issue:6 Topics: Amiloride; Analysis of Variance; Burkholderia cepacia; Colony Count, Microbial; Humans; Microbial Sensitivity Tests; Time Factors; Tobramycin	1994
Role of protein kinase C in the anti-aggregatory effects of endothelin-1 on human platelets. Clinical science (London, England : 1979), 1995, Volume: 88, Issue:3 Topics: Adult; Alkaloids; Amiloride; Blood Platelets; Calcium; Dose-Response Relationship, Drug; Endothelins; Female; Humans; In Vitro Techniques; Male; Middle Aged; Naphthalenes; Platelet Aggregation; Platelet Aggregation Inhibitors; Polycyclic Compounds; Protein Kinase C; Sodium-Hydrogen Exchangers; Staurosporine; Thrombin	1995
Comparative effects of Na+/H+ exchange inhibitors against cardiac injury produced by ischemia/reperfusion, hypoxia/reoxygenation, and the calcium paradox. Journal of cardiovascular pharmacology, 1993, Volume: 21, Issue:1 Topics: Adenosine Triphosphate; Amiloride; Animals; Bepridil; Calcium; Carrier Proteins; Glycogen; Heart; Heart Rate; Hydrogen; Hypoxia; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchangers	1993
Role of Na-H exchangers and vacuolar H+ pumps in intracellular pH regulation in neonatal rat osteoclasts. The Journal of general physiology, 1995, Volume: 105, Issue:2 Topics: 4-Chloro-7-nitrobenzofurazan; Acid-Base Equilibrium; Amiloride; Animals; Animals, Newborn; Buffers; Cell Membrane; Fluoresceins; Hydrogen-Ion Concentration; Osteoclasts; Proton Pumps; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Sodium; Sodium-Hydrogen Exchangers; Vacuoles	1995
Na(+)-Ca2+ exchange in intact endothelium of rabbit cardiac valve. Circulation research, 1995, Volume: 76, Issue:3 Topics: Acetylcholine; Amiloride; Animals; Calcium; Endothelium; Heart Valves; In Vitro Techniques; Lithium; Meglumine; Rabbits; Sodium; Sodium-Hydrogen Exchangers	1995
Mechanisms of pHi control and relationships between tension and pHi in human subcutaneous small arteries. The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 1 Topics: Acetates; Acetic Acid; Adult; Amiloride; Ammonium Chloride; Angiotensin II; Arginine Vasopressin; Arteries; Bicarbonates; Endothelins; Humans; Hydrogen-Ion Concentration; Kinetics; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Skin; Sodium; Sodium-Hydrogen Exchangers	1995
Na+/H+ and Na+/Ca2+ exchange in regulation of [Na+]i and [Ca2+]i during metabolic inhibition. The American journal of physiology, 1995, Volume: 268, Issue:3 Pt 2 Topics: Amiloride; Animals; Antimetabolites; Calcium; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Size; Energy Metabolism; Female; Guinea Pigs; Heart; In Vitro Techniques; Intracellular Fluid; Ion Transport; Myocardium; Protons; Sodium; Sodium-Potassium-Exchanging ATPase; Strophanthidin; Tetrodotoxin	1995
Inhibition of the regulation of intracellular pH: potential of 5-(N,N-hexamethylene) amiloride in tumour-selective therapy. British journal of cancer, 1994, Volume: 70, Issue:4 Topics: Amiloride; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Benzimidazoles; Cell Death; Combined Modality Therapy; Disease Models, Animal; Flow Cytometry; Hydralazine; Hydrogen-Ion Concentration; Intracellular Fluid; Kinetics; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Nigericin; Sarcoma, Experimental; Sodium-Hydrogen Exchangers; Tumor Cells, Cultured	1994
Differential regulation of cation transport of vascular smooth muscle cells in a high glucose concentration milieu. Diabetes research and clinical practice, 1994, Volume: 24, Issue:2 Topics: Amiloride; Analysis of Variance; Animals; Aorta, Thoracic; Calcium; Carrier Proteins; Cations; Cells, Cultured; Diabetic Angiopathies; Glucose; Kinetics; Male; Muscle, Smooth, Vascular; Ouabain; Potassium; Rats; Rats, Wistar; Rubidium; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase	1994
Thermosensitization by increasing intracellular acidity with amiloride and its analogs. International journal of radiation oncology, biology, physics, 1994, Dec-01, Volume: 30, Issue:5 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Cell Division; Cell Line; Dose-Response Relationship, Drug; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred A; Structure-Activity Relationship; Tumor Cells, Cultured	1994
Sodium-proton (Na+/H+) exchange inhibition increases blood pressure in spontaneously hypertensive rat. The American journal of the medical sciences, 1994, Volume: 308, Issue:3 Topics: Amiloride; Animals; Blood Pressure; Hypertension; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium Chloride; Sodium Chloride, Dietary; Sodium-Hydrogen Exchangers	1994
The role of Na+/H+ exchange and the Na+/K+ pump in the regulation of [Na+]i during metabolic inhibition in guinea pig myocytes. Biochemical and biophysical research communications, 1994, Aug-30, Volume: 203, Issue:1 Topics: Amiloride; Analysis of Variance; Animals; Cells, Cultured; Female; Fluorescent Dyes; Guinea Pigs; Homeostasis; Hydrogen-Ion Concentration; Kinetics; Muscles; Sodium; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase	1994
Effects of HMA, an analog of amiloride, on the thermosensitivity of tumors in vivo. International journal of radiation oncology, biology, physics, 1994, Aug-30, Volume: 30, Issue:1 Topics: Amiloride; Animals; Cell Death; Cell Division; Hydrogen-Ion Concentration; Hyperthermia, Induced; Mammary Neoplasms, Experimental; Mice; Mice, Inbred A; Sodium-Hydrogen Exchangers; Spectrometry, Fluorescence; Tumor Cells, Cultured	1994
Mechanism of acidification along cortical distal tubule of the rat. The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2 Topics: Amiloride; Animals; Anti-Bacterial Agents; Antifungal Agents; Bicarbonates; Epithelium; Hydrogen-Ion Concentration; Imidazoles; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Distal; Kinetics; Macrolides; Male; Membrane Potentials; Perfusion; Potassium Deficiency; Proton Pump Inhibitors; Proton-Translocating ATPases; Rats; Rats, Wistar	1994
Regulation of [Na+]i and [Ca2+]i in guinea pig myocytes: dual loading of fluorescent indicators SBFI and fluo 3. The American journal of physiology, 1994, Volume: 266, Issue:2 Pt 2 Topics: Amiloride; Aniline Compounds; Animals; Benzofurans; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Ethers, Cyclic; Female; Fluorescent Dyes; Guinea Pigs; Heart; Kinetics; Myocardial Contraction; Myocardium; Nickel; Sodium; Spectrometry, Fluorescence; Strophanthidin; Xanthenes	1994
The effect of sodium transport and calcium channel inhibitors on phorbol ester-induced contraction of bovine airway smooth muscle. Pulmonary pharmacology, 1993, Volume: 6, Issue:4 Topics: Amiloride; Animals; Biological Transport; Bronchi; Calcium; Calcium Channel Blockers; Cattle; Drug Interactions; Edetic Acid; Furosemide; Glucose; In Vitro Techniques; Muscle Contraction; Muscle, Smooth; Peptides; Phorbol 12,13-Dibutyrate; Sodium; Sodium Channels; Tromethamine	1993
Na+/H+ exchange inhibitors reverse lactate-induced depression in postischaemic ventricular recovery. British journal of pharmacology, 1993, Volume: 108, Issue:1 Topics: Amiloride; Animals; Carrier Proteins; Heart; Hydrogen; In Vitro Techniques; Lactates; Lactic Acid; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchangers	1993
Increase in thermosensitivity of tumor cells by lowering intracellular pH. Cancer research, 1993, Apr-01, Volume: 53, Issue:7 Topics: Amiloride; Animals; Carrier Proteins; Chloride-Bicarbonate Antiporters; Fluorenes; Hydrogen-Ion Concentration; Hyperthermia, Induced; Mammary Neoplasms, Animal; Mice; Sodium-Hydrogen Exchangers; Temperature; Time Factors; Tumor Cells, Cultured	1993
Opposite effects of amiloride and amiloride analogues on activation of natural killer cytotoxicity by the phorbol ester TPA and gamma-interferon. Immunology letters, 1993, Volume: 35, Issue:2 Topics: Amiloride; Dose-Response Relationship, Drug; Humans; Interferon-gamma; Killer Cells, Natural; Sodium Channels; Tetradecanoylphorbol Acetate; Tetrodotoxin	1993
Altered Na(+)- H(+)- exchange activity in the spontaneously hypertensive perfused rat heart. Journal of molecular and cellular cardiology, 1995, Volume: 27, Issue:8 Topics: Acidosis; Amiloride; Animals; Carbon Dioxide; Heart; Hydrogen-Ion Concentration; Hypertension; In Vitro Techniques; Kinetics; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium; Sodium-Hydrogen Exchangers; Time Factors	1995
Intracellular sodium concentration in diabetic rat ventricular myocytes. Japanese heart journal, 1995, Volume: 36, Issue:5 Topics: Amiloride; Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Male; Myocardium; Rats; Rats, Wistar; Sodium; Sodium-Hydrogen Exchangers; Streptozocin	1995
Transient prolongation of ventricular action potential duration after metabolic inhibition. Japanese heart journal, 1995, Volume: 36, Issue:6 Topics: Action Potentials; Amiloride; Animals; Anti-Arrhythmia Agents; Calcium Channel Blockers; Cell Hypoxia; Dogs; Female; Heart; Heart Ventricles; Lanthanum; Male; Myocardium; Oxygen Consumption; Ventricular Function; Verapamil	1995
Inhibitors of intracellular pH regulation induce cisplatin resistance in EMT6 mouse mammary tumor cells. Oncology research, 1995, Volume: 7, Issue:7-8 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Cisplatin; Cross-Linking Reagents; Drug Resistance, Neoplasm; Hydrogen-Ion Concentration; Mammary Neoplasms, Experimental; Mice; Tumor Cells, Cultured	1995
Influence of pH on the cytotoxicity of cisplatin in EMT6 mouse mammary tumor cells. Oncology research, 1995, Volume: 7, Issue:7-8 Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Amiloride; Animals; Antineoplastic Agents; Cell Survival; Cisplatin; Cross-Linking Reagents; Drug Resistance, Neoplasm; Hydrogen-Ion Concentration; Mammary Neoplasms, Experimental; Mice; Sodium Bicarbonate; Tumor Cells, Cultured; Tumor Stem Cell Assay	1995
Increased resistance to acute respiratory acidosis in isolated cardiac muscle following chronic hypoxia-induced hypertrophy. Cardiovascular research, 1996, Volume: 31, Issue:5 Topics: Acidosis, Respiratory; Amiloride; Animals; Chronic Disease; Hypertrophy, Right Ventricular; Hypoxia; In Vitro Techniques; Male; Papillary Muscles; Rats; Rats, Wistar; Sodium-Hydrogen Exchangers	1996
Role of the Na(+)-Ca2+ and Na(+)-H+ antiporters in prolactin release from anterior pituitary cells in primary culture. European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1 Topics: Amiloride; Animals; Antiporters; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Female; Ouabain; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Wistar; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Thyrotropin-Releasing Hormone	1995
Na(+)-H+ and Na(+)-Li+ exchange are mediated by the same membrane transport protein in human red blood cells: an NMR investigation. Biochemistry, 1996, Sep-24, Volume: 35, Issue:38 Topics: Amiloride; Antiporters; Biological Transport; Erythrocyte Membrane; Erythrocytes; Humans; Hydrogen; Hydrogen-Ion Concentration; Kinetics; Lithium; Magnetic Resonance Spectroscopy; Phloretin; Sodium; Sodium-Hydrogen Exchangers; Spectrophotometry, Atomic	1996
Regulation of rat proximal tubule Na/H exchange by protein kinase C. Kidney & blood pressure research, 1996, Volume: 19, Issue:2 Topics: Acids; Amiloride; Animals; Bicarbonates; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Kidney Tubules, Proximal; Kinetics; Male; Phorbol Esters; Phosphoric Monoester Hydrolases; Protein Kinase C; Rats; Rats, Wistar; Signal Transduction; Sodium-Hydrogen Exchangers	1996
Effect of luminal angiotensin II and ANP on early and late cortical distal tubule HCO3- reabsorption. The American journal of physiology, 1996, Volume: 271, Issue:5 Pt 2 Topics: Absorption; Amiloride; Angiotensin II; Animals; Anti-Bacterial Agents; Atrial Natriuretic Factor; Bicarbonates; Biphenyl Compounds; Enzyme Inhibitors; Imidazoles; Kidney Cortex; Kidney Tubules, Distal; Losartan; Macrolides; Male; Rats; Rats, Wistar; Tetrazoles	1996
Properties of the pore-forming P2X7 purinoceptor in mouse NTW8 microglial cells. British journal of pharmacology, 1997, Volume: 121, Issue:7 Topics: Adenosine Triphosphate; Amiloride; Animals; Cell Line; Ethidium; Mice; Microglia; Receptors, Purinergic P2	1997
Luminal arginine vasopressin stimulates Na(+)-H+ exchange and H(+)-ATPase in cortical distal tubule via V1 receptor. Kidney international, 1997, Volume: 52, Issue:4 Topics: Amiloride; Animals; Anti-Bacterial Agents; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Enzyme Inhibitors; Kidney Cortex; Kidney Tubules, Distal; Macrolides; Male; Osmolar Concentration; Proton-Translocating ATPases; Rats; Rats, Wistar; Receptors, Vasopressin; Sodium-Hydrogen Exchangers	1997
Intracellular pH increase driven by an Na+/H+ exchanger upon activation of surf clam oocytes. Developmental biology, 1997, Oct-01, Volume: 190, Issue:1 Topics: Amiloride; Ammonium Chloride; Animals; Bivalvia; Cell Nucleus; Cytoplasm; Dimethadione; Fertilization; Fluoresceins; Fluorescent Dyes; Hydrogen-Ion Concentration; Meiosis; Oocytes; Potassium Chloride; Sodium Chloride; Sodium-Hydrogen Exchangers	1997
The Na+-I- cotransporter of the thyroid: characterisation of new inhibitors. Pflugers Archiv : European journal of physiology, 1998, Volume: 435, Issue:2 Topics: Amiloride; Animals; Biological Transport; Carrier Proteins; Cattle; Cell Membrane; Econazole; Iodides; Iodine Radioisotopes; Kinetics; Liposomes; Marine Toxins; Membrane Proteins; Symporters; Thiazoles; Thyroid Gland	1998
Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-kappaB activation. The Journal of biological chemistry, 1998, Feb-27, Volume: 273, Issue:9 Topics: Acids; Amiloride; Animals; Autocrine Communication; Cell Nucleus; Culture Media; Cysteine Proteinase Inhibitors; Enzyme Induction; Genes, Reporter; Hydrogen-Ion Concentration; Leupeptins; Macrophages, Peritoneal; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Transcription, Genetic; Tumor Necrosis Factor-alpha	1998
Inhibition of bicarbonate transport protects embryonic heart against reoxygenation-induced dysfunction. Journal of molecular and cellular cardiology, 1998, Volume: 30, Issue:2 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Acidosis; Amiloride; Animals; Arrhythmias, Cardiac; Bicarbonates; Chick Embryo; Heart; Heart Rate; Hydrogen-Ion Concentration; Ion Transport; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Sodium-Hydrogen Exchangers	1998
Selective impairment of HCO3(-)-dependent pHi regulation by lysophosphatidylcholine in guinea pig ventricular myocardium. Cardiovascular research, 1998, Volume: 37, Issue:1 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Carrier Proteins; Guinea Pigs; Hydrogen-Ion Concentration; Intracellular Fluid; Lysophosphatidylcholines; Membrane Potentials; Myocardial Ischemia; Myocardium; Papillary Muscles; Phosphatidylcholines; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers	1998
Role of physiological HCO3-buffer on intracellular pH and histamine release in rat peritoneal mast cells. Pflugers Archiv : European journal of physiology, 1998, Volume: 436, Issue:3 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Animals; Antigens; Antiporters; Bicarbonates; Biological Transport; Buffers; Carbonic Anhydrase Inhibitors; Chloride-Bicarbonate Antiporters; Chlorides; Dichlorphenamide; Histamine; Hydrogen-Ion Concentration; In Vitro Techniques; Intracellular Fluid; Male; Mast Cells; p-Methoxy-N-methylphenethylamine; Peritoneal Cavity; Rats; Rats, Sprague-Dawley; Sodium	1998
A single cell model of myocardial reperfusion injury: changes in intracellular Na+ and Ca2+ concentrations in guinea pig ventricular myocytes. Molecular and cellular biochemistry, 1999, Volume: 194, Issue:1-2 Topics: Amiloride; Animals; Calcium; Female; Guinea Pigs; Heart Ventricles; Hydrogen-Ion Concentration; Models, Biological; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Ryanodine; Sodium	1999
Na+ :H+ exchange inhibition induces intracellular acidosis and differentially impairs cell growth and viability of human and rat hepatocarcinoma cells. Toxicology letters, 1999, Jun-01, Volume: 106, Issue:2-3 Topics: Acidosis; Amiloride; Animals; Antineoplastic Agents; Calcium; Carcinoma, Hepatocellular; Cell Division; Cell Survival; DNA; Dose-Response Relationship, Drug; Humans; Liver Neoplasms; Rats; Sodium; Tumor Cells, Cultured	1999
Permeation of NH3/NH4+ and cell pH in colonic crypts of the rat. Pflugers Archiv : European journal of physiology, 1999, Volume: 438, Issue:4 Topics: Amiloride; Ammonia; Animals; Barium; Chlorides; Colon; Drug Combinations; Furosemide; Hydrogen; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Permeability; Quaternary Ammonium Compounds; Rats; Rats, Wistar	1999
Apoptosis of leukemic cells accompanies reduction in intracellular pH after targeted inhibition of the Na(+)/H(+) exchanger. Blood, 2000, Feb-15, Volume: 95, Issue:4 Topics: Adult; Amiloride; Animals; Antineoplastic Agents; Apoptosis; Humans; Hydrogen-Ion Concentration; K562 Cells; Leukemia; Lymphocytes; Mice; Mice, Inbred NOD; Mice, SCID; Sodium-Hydrogen Exchangers; Tetradecanoylphorbol Acetate; Transplantation, Heterologous; Tumor Cells, Cultured	2000
Calcium and osmotic regulation of the Na+/H+ exchanger in neonatal ventricular myocytes. Journal of molecular and cellular cardiology, 2000, Volume: 32, Issue:6 Topics: Amiloride; Angiotensin II; Animals; Animals, Newborn; Calcium; Calmodulin; Cells, Cultured; CHO Cells; Choline; Cricetinae; Endothelin-1; Heart Ventricles; Imidazoles; Meglumine; Myocardium; Pyridines; Rats; Rats, Sprague-Dawley; Sodium Chloride; Sodium-Hydrogen Exchangers; Sorbitol; Sulfonamides; Trifluoperazine; Water-Electrolyte Balance	2000
Allosteric modulation of A(2A) adenosine receptors by amiloride analogues and sodium ions. Biochemical pharmacology, 2000, Sep-01, Volume: 60, Issue:5 Topics: Allosteric Regulation; Amiloride; Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Diuretics; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Purinergic P1 Receptor Antagonists; Radiopharmaceuticals; Rats; Receptor, Adenosine A2A; Receptors, Purinergic P1; Sodium; Sodium Chloride; Time Factors; Triazines; Triazoles; Tritium	2000
Control of cell pH in the T84 colon cell line. The Journal of membrane biology, 2000, Sep-15, Volume: 177, Issue:2 Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Amiloride; Antiporters; Biological Transport; Carrier Proteins; Cell Physiological Phenomena; Chloride-Bicarbonate Antiporters; Colonic Neoplasms; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Sodium; Sodium-Bicarbonate Symporters; Sodium-Hydrogen Exchangers; Tumor Cells, Cultured	2000
Intracellular pH on translocation of protein kinase C isozymes in rat pinealocytes. Journal of neurochemistry, 2000, Volume: 75, Issue:5 Topics: Amiloride; Ammonium Chloride; Animals; Cell Membrane; Cells, Cultured; Chelating Agents; Egtazic Acid; Hydrogen-Ion Concentration; Intracellular Fluid; Isoenzymes; Male; Norepinephrine; Pineal Gland; Propionates; Protein Kinase C; Protein Transport; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate	2000
Complexities of measuring antagonist potency at P2X(7) receptor orthologs. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 296, Issue:3 Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amiloride; Animals; Benzoxazoles; Buffers; Cations, Divalent; Cell Adhesion; Cells, Cultured; Drug Interactions; Enzyme Inhibitors; Ethidium; Fluorescent Dyes; Humans; Kinetics; Mice; Platelet Aggregation Inhibitors; Purinergic P2 Receptor Antagonists; Pyridoxal Phosphate; Quinolinium Compounds; Rats; Receptors, Purinergic P2; Receptors, Purinergic P2X7; Rosaniline Dyes; Serum Albumin, Bovine; Sodium Chloride; Species Specificity; Temperature	2001
Characterization of stretch-activated cation current in coronary smooth muscle cells. American journal of physiology. Heart and circulatory physiology, 2001, Volume: 280, Issue:4 Topics: Amiloride; Animals; Apamin; Arterioles; Calcium; Coronary Vessels; Evoked Potentials; Female; In Vitro Techniques; Male; Membrane Potentials; Muscle Contraction; Muscle, Smooth, Vascular; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Potassium Channels; Swine	2001
Role of Na(+)/H(+) exchanger in dilator responses of rat basilar artery in vivo. Brain research, 2001, Jul-06, Volume: 906, Issue:1-2 Topics: Acetylcholine; Amiloride; Animals; Antineoplastic Agents; Basilar Artery; Bradykinin; Cerebrovascular Circulation; Endothelium, Vascular; Male; Methylamines; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Vasodilation	2001
Amiloride blockades lipopolysaccharide-induced proinflammatory cytokine biosynthesis in an IkappaB-alpha/NF-kappaB-dependent mechanism. Evidence for the amplification of an antiinflammatory pathway in the alveolar epithelium. American journal of respiratory cell and molecular biology, 2002, Volume: 26, Issue:1 Topics: Active Transport, Cell Nucleus; Amiloride; Animals; Antineoplastic Agents; Cells, Cultured; Cytokines; Diuretics; DNA-Binding Proteins; Dose-Response Relationship, Drug; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; I-kappa B Proteins; Interleukin-1; Interleukin-10; Interleukin-6; Lipopolysaccharides; Lung; Models, Biological; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Promoter Regions, Genetic; Rats; Recombinant Proteins; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha; Up-Regulation	2002
Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu. European biophysics journal : EBJ, 2002, Volume: 31, Issue:1 Topics: Amiloride; Amino Acid Sequence; Anti-HIV Agents; Base Sequence; Biophysical Phenomena; Biophysics; DNA, Viral; HeLa Cells; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Ion Channels; Microscopy, Electron; Molecular Sequence Data; Peptide Fragments; Recombinant Proteins; Viral Regulatory and Accessory Proteins	2002
Mechanisms of proton transport in isolated rat osteoclasts attached to bone. Journal of medical and dental sciences, 2000, Volume: 47, Issue:3 Topics: 4-Chloro-7-nitrobenzofurazan; Amiloride; Animals; Bone and Bones; Cell Adhesion; Cell Culture Techniques; Culture Media; Enzyme Inhibitors; Fluorescent Dyes; Glass; Hydrogen-Ion Concentration; Ion Transport; Osteoclasts; Proteolipids; Protons; Rats; Rats, Wistar; Sodium; Sodium-Hydrogen Exchangers; Vacuolar Proton-Translocating ATPases	2000
[Effect of a hypertonic sucrose solution and 5-(N,N-hexamethylene)-amiloride on receptor-mediated and liquid-phase endocytosis]. Tsitologiia, 2002, Volume: 44, Issue:7 Topics: Amiloride; Endocytosis; Epidermal Growth Factor; ErbB Receptors; Humans; Osmolar Concentration; Sucrose; Tumor Cells, Cultured	2002
ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivo. Stroke, 2003, Volume: 34, Issue:5 Topics: Amiloride; Animals; ATP-Binding Cassette Transporters; Basilar Artery; Cells, Cultured; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Glyburide; Hydrogen-Ion Concentration; Indomethacin; Intracellular Fluid; Ion Transport; Macromolecular Substances; Male; Muscle, Smooth, Vascular; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Organ Specificity; Pancreas; Peptides; Potassium; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Inwardly Rectifying; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Drug; Sodium-Hydrogen Exchangers; Sulfonylurea Receptors; Vasodilation	2003
Apoptosis induced by Na+/H+ antiport inhibition activates the LEI/L-DNase II pathway. Cell death and differentiation, 2003, Volume: 10, Issue:5 Topics: Amiloride; Animals; Apoptosis; Cell Line; Cricetinae; Endodeoxyribonucleases; Enzyme Activation; Etoposide; Hydrogen-Ion Concentration; Serpins; Sodium-Hydrogen Exchangers; Time Factors	2003
Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS letters, 2004, Jan-16, Volume: 557, Issue:1-3 Topics: Amiloride; Amino Acid Sequence; Ion Channels; Lipid Bilayers; Membrane Potentials; Molecular Sequence Data; Peptide Fragments; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Viral Proteins	2004
Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages. Antimicrobial agents and chemotherapy, 2004, Volume: 48, Issue:6 Topics: Amiloride; Anti-HIV Agents; Cell Division; Cell Survival; Cells, Cultured; DNA, Viral; HIV Core Protein p24; HIV-1; Human Immunodeficiency Virus Proteins; Humans; Macrophages; RNA, Viral; Viral Regulatory and Accessory Proteins; Virus Replication	2004
Functional role of the Na+/H+ exchanger in the regulation of cerebral arteriolar tone in rats. Journal of neurosurgery, 2004, Volume: 101, Issue:2 Topics: Amiloride; Aniline Compounds; Animals; Antineoplastic Agents; Arterioles; ATPase Inhibitory Protein; Cerebral Cortex; In Vitro Techniques; Male; Microcirculation; Neurokinin A; Nitric Oxide Synthase; Peptide Fragments; Phenyl Ethers; Phosphoproteins; Proteins; Rats; Rats, Sprague-Dawley; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase; Vasoconstriction	2004
Apoptosis induced by 5-(N,N-hexamethylene)-amiloride in regenerating liver after partial hepatectomy. European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3 Topics: Amiloride; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Cell Cycle Proteins; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p21; DNA; DNA Fragmentation; Electrophoresis, Polyacrylamide Gel; Genes, p53; Hepatectomy; Hepatocytes; In Situ Nick-End Labeling; JNK Mitogen-Activated Protein Kinases; Liver Regeneration; Male; Proto-Oncogene Proteins c-jun; Rats; Rats, Wistar; RNA; Signal Transduction; Sodium-Hydrogen Exchangers; Thymidine Kinase; Up-Regulation	2004
Dengue virus M protein C-terminal peptide (DVM-C) forms ion channels. The Journal of membrane biology, 2005, Volume: 204, Issue:1 Topics: Amantadine; Amiloride; Antineoplastic Agents; Antiviral Agents; Dengue Virus; Ion Channels; Membranes, Artificial; Peptides; Viral Matrix Proteins	2005
Signaling pathways in the biphasic effect of ANG II on Na+/H+ exchanger in T84 cells. The Journal of membrane biology, 2005, Volume: 205, Issue:2 Topics: Amiloride; Angiotensin II; Calcium; Cell Line, Tumor; Cell Size; Colon; Colonic Neoplasms; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Hydrogen-Ion Concentration; Isoquinolines; Losartan; Signal Transduction; Sodium-Hydrogen Exchangers; Staurosporine; Sulfonamides	2005
Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication. Virology, 2006, Sep-30, Volume: 353, Issue:2 Topics: Amiloride; Amino Acid Sequence; Animals; Antiviral Agents; Cell Line; Coronavirus; Humans; Ion Channel Gating; Ion Channels; Mice; Molecular Sequence Data; Sodium Channel Blockers; Viral Envelope Proteins; Virus Replication	2006
Acute acidification or amiloride treatment suppresses the ability of Hsp70 to inhibit heat-induced apoptosis. Apoptosis : an international journal on programmed cell death, 2007, Volume: 12, Issue:8 Topics: Acids; Amiloride; Apoptosis; bcl-2-Associated X Protein; Caspase Inhibitors; Caspases; Cell Death; Combined Modality Therapy; Culture Media; Enzyme Activation; Hot Temperature; HSP70 Heat-Shock Proteins; Humans; Hydrogen-Ion Concentration; Hyperthermia, Induced; JNK Mitogen-Activated Protein Kinases; Tumor Cells, Cultured	2007
Role of NHE1 in calcium signaling and cell proliferation in human CNS pericytes. American journal of physiology. Heart and circulatory physiology, 2008, Volume: 294, Issue:4 Topics: Amiloride; Brain; Calcium; Calcium Signaling; Cation Transport Proteins; Cell Proliferation; Cells, Cultured; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Microcirculation; Pericytes; RNA Interference; RNA, Small Interfering; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium; Sodium-Hydrogen Exchanger 1; Sodium-Hydrogen Exchangers; Thapsigargin; Time Factors	2008
Lidocaine increases intracellular sodium concentration through a Na+-H+ exchanger in an identified Lymnaea neuron. Anesthesia and analgesia, 2008, Volume: 106, Issue:5 Topics: Amiloride; Anesthetics, Local; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen-Ion Concentration; Lidocaine; Lymnaea; Mepivacaine; Microscopy, Fluorescence; Neurons; Prilocaine; Sodium; Sodium-Hydrogen Exchangers; Up-Regulation	2008
Inhibition of Na+/H+ exchanger enhances low pH-induced L-selectin shedding and beta2-integrin surface expression in human neutrophils. American journal of physiology. Cell physiology, 2008, Volume: 295, Issue:5 Topics: Amiloride; Ammonium Chloride; CD11b Antigen; CD18 Antigens; Cell Membrane; Guanidines; Humans; Hydrogen-Ion Concentration; L-Selectin; Lactic Acid; Macrophage-1 Antigen; Metalloproteases; Neutrophils; p38 Mitogen-Activated Protein Kinases; Protease Inhibitors; Protein Kinase Inhibitors; Reperfusion Injury; Sodium-Hydrogen Exchangers; Sulfones; Time Factors	2008
Amiloride derivatives induce apoptosis by depleting ER Ca(2+) stores in vascular endothelial cells. British journal of pharmacology, 2009, Volume: 156, Issue:8 Topics: Amiloride; Antigens, Differentiation; Apoptosis; Calcium; Cell Cycle Proteins; Diuretics; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Endothelial Cells; Enzyme Inhibitors; Guanidines; HeLa Cells; Humans; Hydrogen-Ion Concentration; Kinetics; Protein Phosphatase 1; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Hydrogen Exchangers; Sulfones; Thapsigargin; Transcription Factor CHOP; Transcription, Genetic	2009
Structure and inhibition of the SARS coronavirus envelope protein ion channel. PLoS pathogens, 2009, Volume: 5, Issue:7 Topics: Amiloride; Cell Line; Humans; Ion Channels; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Patch-Clamp Techniques; Protein Binding; Protein Conformation; Protein Stability; Protein Structure, Tertiary; Reproducibility of Results; Severe acute respiratory syndrome-related coronavirus; Viral Envelope Proteins	2009
Effects of extracellular pH reductions on [(3)H]D-aspartate and [(3)H]noradrenaline release by presynaptic nerve terminals isolated from rat cerebral cortex. Journal of neural transmission (Vienna, Austria : 1996), 2010, Volume: 117, Issue:1 Topics: Amiloride; Animals; Aspartic Acid; Calcium; Central Nervous System Agents; Cerebral Cortex; D-Aspartic Acid; Desipramine; Extracellular Space; Hydrogen-Ion Concentration; Male; Neurons; Norepinephrine; Presynaptic Terminals; Rats; Rats, Wistar; Synaptosomes; Time Factors; Tritium	2010
NMR structure and ion channel activity of the p7 protein from hepatitis C virus. The Journal of biological chemistry, 2010, Oct-08, Volume: 285, Issue:41 Topics: Amiloride; Amino Acid Motifs; Circular Dichroism; Hepacivirus; Ion Channels; Lipid Bilayers; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Multimerization; Protein Structure, Quaternary; Viral Proteins	2010
Pharmacological characterisation of apical Na+ and Cl- transport mechanisms of the anal papillae in the larval mosquito Aedes aegypti. The Journal of experimental biology, 2011, Dec-01, Volume: 214, Issue:Pt 23 Topics: Aedes; Amiloride; Anal Canal; Animals; Bumetanide; Carbonic Anhydrases; Chlorides; Ion Transport; Ion-Selective Electrodes; Larva; Macrolides; Methazolamide; Microelectrodes; Models, Biological; Ouabain; Sodium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Vacuolar Proton-Translocating ATPases	2011
Fluorescence properties of the Na⁺/H⁺exchanger inhibitor HMA (5-(N,N-hexamethylene)amiloride) are modulated by intracellular pH. European journal of histochemistry : EJH, 2012, Jan-20, Volume: 56, Issue:1 Topics: Amiloride; Antineoplastic Agents; Cell Line; Fluorescent Dyes; Humans; Hydrogen-Ion Concentration; Microscopy, Fluorescence; Sodium-Hydrogen Exchangers; Ultraviolet Rays	2012
Characterization of stress response in human retinal epithelial cells. Journal of cellular and molecular medicine, 2013, Volume: 17, Issue:1 Topics: Adaptor Proteins, Signal Transducing; Adult; Amiloride; Apoptosis; Autophagy; Biological Transport, Active; Caspases; Cell Count; Cell Line; Cell Survival; Epithelial Cells; Etoposide; Gene Expression; Humans; Oxidative Stress; Reactive Oxygen Species; Retinal Pigment Epithelium; Sequestosome-1 Protein; Signal Transduction; Sodium-Hydrogen Exchangers; Topoisomerase Inhibitors	2013
Potential role of sodium-proton exchangers in the low concentration arsenic trioxide-increased intracellular pH and cell proliferation. PloS one, 2012, Volume: 7, Issue:12 Topics: Amiloride; Analysis of Variance; Animals; Arsenic Trioxide; Arsenicals; Blotting, Western; Carbazoles; Cell Count; Cell Fractionation; Cell Proliferation; Dogs; Flavonoids; Fluorometry; Hydrogen-Ion Concentration; Imidazoles; Macrolides; Madin Darby Canine Kidney Cells; Oxides; Sodium-Hydrogen Exchangers	2012
Multiple effects of the Na(+)/H (+) antiporter inhibitor HMA on cancer cells. Apoptosis : an international journal on programmed cell death, 2013, Volume: 18, Issue:12 Topics: Amiloride; Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Cell Survival; Colonic Neoplasms; Humans; Sodium-Hydrogen Exchangers	2013
The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor. Structure (London, England : 1993), 2013, Dec-03, Volume: 21, Issue:12 Topics: Adenosine A2 Receptor Agonists; Adenosine A2 Receptor Antagonists; Allosteric Regulation; Allosteric Site; Amiloride; Amino Acid Sequence; Cations, Monovalent; HEK293 Cells; Hot Temperature; Humans; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Conformation; Protein Stability; Radioligand Assay; Receptor, Adenosine A2A; Sodium	2013
Differential effects of viroporin inhibitors against feline infectious peritonitis virus serotypes I and II. Archives of virology, 2015, Volume: 160, Issue:5 Topics: Amiloride; Animals; Antiviral Agents; Cats; Coronavirus, Feline; Dose-Response Relationship, Drug; Microbial Sensitivity Tests; Serogroup; Viral Envelope Proteins; Viral Load; Virus Replication	2015
Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells. Cancer letters, 2016, May-28, Volume: 375, Issue:1 Topics: Amiloride; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Cisplatin; Docetaxel; Doxorubicin; Drug Screening Assays, Antitumor; Female; Humans; Lysosomes; Necrosis; Reactive Oxygen Species; Taxoids	2016
Structural basis of interaction between the hepatitis C virus p7 channel and its blocker hexamethylene amiloride. Protein & cell, 2016, Volume: 7, Issue:4 Topics: Amiloride; Binding Sites; Genotype; Hepacivirus; Humans; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Protein Structure, Tertiary; Viral Proteins	2016
Mechanisms of Action of Novel Influenza A/M2 Viroporin Inhibitors Derived from Hexamethylene Amiloride. Molecular pharmacology, 2016, Volume: 90, Issue:2 Topics: Amantadine; Amiloride; Animals; Antiviral Agents; Cell Death; Cell Line; Guanidines; Humans; Hydrogen-Ion Concentration; Influenza A virus; Influenza A Virus, H9N2 Subtype; Ion Channel Gating; Mice; Molecular Docking Simulation; Patch-Clamp Techniques; Viral Matrix Proteins	2016
5-(N, N-Hexamethylene) amiloride is a GABA-A ρ1 receptor positive allosteric modulator. Channels (Austin, Tex.), 2016, Volume: 10, Issue:6 Topics: Allosteric Regulation; Amiloride; Binding Sites; Electrophysiology; gamma-Aminobutyric Acid; Guanidine; HEK293 Cells; Humans; Mutagenesis, Site-Directed; Receptors, GABA-B	2016
Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage. BMC cancer, 2016, 11-05, Volume: 16, Issue:1 Topics: Amiloride; Antineoplastic Agents; Apoptosis; Autophagy; Cell Shape; DNA Damage; Drug Screening Assays, Antitumor; HCT116 Cells; Humans; Membrane Potential, Mitochondrial; Mitochondria; Phthalazines; Piperazines; Poly Adenosine Diphosphate Ribose; Reactive Oxygen Species; Receptor-Interacting Protein Serine-Threonine Kinases; Sodium-Hydrogen Exchangers	2016
Structure and drug binding of the SARS-CoV-2 envelope protein transmembrane domain in lipid bilayers. Nature structural & molecular biology, 2020, Volume: 27, Issue:12 Topics: Amantadine; Amiloride; Antiviral Agents; Coronavirus Envelope Proteins; Dimyristoylphosphatidylcholine; Hydrogen-Ion Concentration; Lipid Bilayers; Magnetic Resonance Spectroscopy; Models, Molecular; Phenylalanine; Phospholipids; Protein Conformation; Protein Domains; SARS-CoV-2	2020
Amantadine has potential for the treatment of COVID-19 because it inhibits known and novel ion channels encoded by SARS-CoV-2. Communications biology, 2021, 12-01, Volume: 4, Issue:1 Topics: Amantadine; Amiloride; Antiviral Agents; Ion Channels; Rimantadine; SARS-CoV-2; Viral Proteins	2021
6-Furopyridine Hexamethylene Amiloride Is a Non-Selective P2X7 Receptor Antagonist. Biomolecules, 2022, 09-16, Volume: 12, Issue:9 Topics: Adenosine; Adenosine Triphosphate; Amiloride; Animals; Dogs; HEK293 Cells; Humans; Interleukin-1beta; Mice; Purinergic P2X Receptor Antagonists; Receptors, Purinergic P2X7	2022
In Silico Evaluation of Hexamethylene Amiloride Derivatives as Potential Luminal Inhibitors of SARS-CoV-2 E Protein. International journal of molecular sciences, 2022, Sep-13, Volume: 23, Issue:18 Topics: Amiloride; Amino Acids; COVID-19 Drug Treatment; Humans; Ion Channels; Molecular Docking Simulation; Molecular Dynamics Simulation; SARS-CoV-2	2022
Automated Patch Clamp Screening of Amiloride and 5- Molecular pharmaceutics, 2023, 07-03, Volume: 20, Issue:7 Topics: Acid Sensing Ion Channels; Amiloride; Animals; Neurons; Rats	2023
Hexamethylene amiloride binds the SARS-CoV-2 envelope protein at the protein-lipid interface. Protein science : a publication of the Protein Society, 2023, Volume: 32, Issue:10 Topics: Amiloride; COVID-19; Humans; Lipid Bilayers; SARS-CoV-2	2023