amifostine anhydrous and wr 1065

amifostine anhydrous has been researched along with wr 1065 in 101 studies

Research

Studies (101)

Timeframe	Studies, this research(%)	All Research%
pre-1990	27 (26.73)	18.7374
1990's	26 (25.74)	18.2507
2000's	35 (34.65)	29.6817
2010's	13 (12.87)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Angelis, KJ; Bačíková, A; Dušek, L; Falk, M; Falková, I; Galbavý, Š; Hofer, M; Klejdus, B; Komůrková, D; Kozubek, S; Pagáčová, E; Štefančíková, L; Weiterová, L	1
Purdie, JW	1
Fichtinger-Schepman, AM; Nijtmans, LG; Treskes, M; van der Vijgh, WJ	1
Holwerda, U; Nijtmans, LG; Pinedo, HM; Treskes, M; van der Vijgh, WJ	1
Geary, RS; Mangold, DJ; Swynnerton, NF; Timmons, SF	1
Holwerda, U; Klein, I; Pinedo, HM; Treskes, M; van der Vijgh, WJ	1
Andó, A; Hermann, R; Horváth, I; Rónai, E; Szabados, G; Tretter, L	1
Carroll, FI; Gopinathan, MB; Philip, A	1
Bonjour, JP; Donati, Y; Kondo, M; Polla, BS; Tochon-Danguy, HJ	1
Geary, RS; Ludden, T; Mangold, DJ; Miller, MA; Swynnerton, NF	1
Hunt, WA; Kandasamy, SB; Kumar, KS; Weiss, JF	1
Meyn, RE; Milas, L; Murray, D	1
Aguilera, JA; Calabro-Jones, PM; Fahey, RC; Smoluk, GD; Ward, JF	2
Grdina, DJ; Nagy, B; Sigdestad, CP	1
Blakely, WF; Buchner, J; Pizzitola, V; Walden, TL	1
Schor, NF	1
Calabro-Jones, PM; Fahey, RC; Smoluk, GD; Ward, JF	1
Broch, H; Kranck, H; Rix-Montel, MA; Savant-Ros, E; Vasilescu, D	1
Fahey, RC; Newton, GL	1
Butler, JD; Gahl, WA; Tietze, F	1
Fahey, RC; Smoluk, GD; Ward, JF	1
Brown, DQ; Gold, J; Hardiman, J; Mann, DJ; Pittock, JW; Pogach, R; Shaw, LM	1
Huelle, BK; Ludden, TM; Mangold, DJ; Swynnerton, NF	1
Bonner, HS; Glover, DJ; Kligerman, MM; Norfleet, AL; Shaw, LM; Turrisi, AT; Weiler, C	1
Anderson, KW; Grunbaum, Z; Krohn, KA; Mahler, PA; Menard, TW; Phillips, RB; Rasey, JS; Spence, AM	1
Fahey, RC; Newton, GL; Seaver, N; Utley, JF	1
Cerami, A; Peterson, CM; Tabachnik, NF	1
Rix-Montel, MA; Vasilescu, D	1
Blackburn, P; Cerami, A; Peterson, CM; Tabachnik, NF	1
Gaugas, JM	1
Inhaber, ER; Labelle, JL; Purdie, JW; Schneider, H	1
Aoyama, T; Horikawa, M; Kimura, H; Mori, T; Nikaido, P; Sugahara, T; Watanabe, M	1
Antoku, S	1
Blackburn, P; Peterson, CM	1
Issels, RD; Meier, T	1
Donath, A; Jolliet, P; Polla, B; Slosman, D	1
Carrithers, SL; Lefer, AM; Nuss, C; Owen, CS; Parkinson, SJ; Pooler, PM; Ryan, SV; Skurk, C; Waldman, SA	1
Capizzi, R	1
Bonner, H; Lieberman, R; Shaw, LM	1
Capizzi, RL; Glinsmann-Gibson, B; Heaton, R; List, AF	1
Dorr, RT; Lagel, K; McLean, S	1
Gall, HE; Korst, AE; van der Vijgh, WJ; Vermorken, JB	1
Charlier, M; Hugot, S; Sabattier, R; Savoye, C; Spotheim-Maurizot, M; Swenberg, C; Sy, D	1
Berthold, F; Fulda, S; Oster, W	1
Korst, AE; van der Vijgh, WJ; Vermorken, JB	1
Eeltink, CM; Korst, AE; van der Vijgh, WJ; Vermorken, JB	1
Bernstein, ML; Dubowy, RL; Fahey, RC; Newton, GL; Souid, AK	1
Dorr, RT	1
Capizzi, RL	1
Calabresi, P; Nici, L	1
List, AF	1
Geldof, AA; Heimans, JJ; Postma, TJ; Verstappen, CC	1
Bonner, HS; Shaw, LM	1
Grdina, DJ; Kataoka, Y; Murley, JS; Patel, R	1
Gerner, EW; List, AF	1
Ensminger, WD; Lawrence, TS; Levi, M; Smith, DE; Symon, Z	1
Berthold, F; Fichtner, I; Fulda, S; Hero, B	1
Vos, O	1
Baruchel, S; Fouladi, M; Gammon, J; Grant, R; Greenberg, ML; Klein, J; Koren, G; Stempak, D	1
Aktas, MK; Bernstein, ML; Dubowy, RL; Fahey, RC; Karjoo, S; Newton, GL; Sadowitz, PD; Sayin, OA; Souid, AK	1
Damiani, D; Ermacora, A; Masolini, P; Michelutti, A; Michieli, M; Russo, D; Stocchi, R	1
Grdina, DJ; Hunter, N; Kataoka, Y; Milas, L; Murley, JS; Weichselbaum, RR	1
Epperly, W; Grdina, DJ; Kataoka, Y; Murley, JS	1
Berlion, M; Marchal, S; Merlin, JL; Poullain, MG; Ramacci, C	1
Calvin, DP; Grdina, DJ; Kataoka, Y; Murley, JS	1
Belkacémi, Y; Christen, MO; Piel, G; Rat, P; Touboul, E; Warnet, JM	1
Gerner, EW; List, AF; Quiñones, HI	1
Bai, F; Hanna, SK; Kirstein, MN; Stewart, CF	1
Grdina, DJ; Kataoka, Y; Khodarev, NN; Murley, JS; Weichselbaum, RR	2
Ben-Josef, E; Biggar, S; Bonner, HS; Han, S; Kaplan, I; Kelly, L; Prokop, S; Shaw, LM; Stamos, B; Tobi, M; Vargas, BJ	1
Bachy, CM; Cassatt, DR; Fazenbaker, CA; Kifle, G	3
Jackson, W; Kumar, KS; Seed, TM; Singh, VK	1
DeRemer, SJ; Dou, C; Ensminger, WD; Levi, M; Smith, DE	1
Amat, E; Moreno, V; Prieto, MJ	1
Koukourakis, MI	1
Eaton, JW; Persson, HL; Yu, Z	1
Bachy, CM; Cassatt, DR; Fazenbaker, CA; Kifle, G; McCarthy, MP	2
Cao, D; Grdina, DJ; Kataoka, Y; Li, JJ; Murley, JS; Oberley, LW	1
Chen, J; Lawrence, TS; Lu, Z; Smith, DE	1
Calistri, E; Candoni, A; Damiani, D; Fanin, R; Michelutti, A; Russo, D; Stocchi, R; Tiribelli, M	1
Baker, KL; Diamond, AM; Grdina, DJ; Kataoka, Y; Morgan, WF; Murley, JS	1
Baulch, JE; Coleman, MC; Dziegielewski, J; Goetz, W; Grdina, DJ; Morgan, WF; Murley, JS; Spitz, DR	1
Baker, KL; Coleman, MC; Grdina, DJ; Kataoka, Y; Kunnavakkam, R; Murley, JS; Spitz, DR	1
Garrigues, JC; Poteau, R; Prouillac, C; Rima, G; Vicendo, P	1
Baulch, JE; Dziegielewski, J; Goetz, W; Grdina, DJ; Morgan, WF; Murley, JS	1
Bai, F; Fouladi, M; Gajjar, A; McKibbin, T; Okcu, MF; Panetta, JC; Stewart, CF	1
Baker, KL; Darga, TE; Grdina, DJ; Miller, RC; Murley, JS; Weichselbaum, RR	1
Ben-Josef, E; Chen, J; Ensminger, W; Feng, M; Feng, MR; Knol, JA; Lawrence, TS; Lu, Z; Normolle, DP; Pan, CC; Smith, DE	1
Bermejo, M; Foroutan, M; González-Álvarez, I; Mangas-Sanjuan, V; Samiei, N; Shafaati, A; Zarghi, A	1
Chen, N; Huang, T; Li, C; Ou, M; Wang, S	1
Omar, SI; Tuszynski, J	1
Chan, LP; Chang, LC; Chen, CH; Kuo, ML; Liao, WC; Lin, J; Wang, JL	1
Liu, S; Liu, X; Na, W; Su, X	1
Buchman, L; Buchman, SR; Donneys, A; Lipka, E; Lynn, J; Nelson, N; Ranganathan, K; Reyna, D; Rodriguez, J; Simon, E; Snider, A; Zhang, Y	1
Benoit, DSW; Hansen, ME; Korshunov, VA; Mickelsen, D; Newlands, SD; Ovitt, CE; Schmale, IL; Varghese, JJ	1
Chan, WK; Dantzer, R; de la Cruz Bonilla, M; Deorukhkar, A; Fujimoto, TN; Garcia, CJG; Grossberg, AJ; Horvath, TD; Lin, D; Lorenzi, PL; Mason, KA; Molkentine, JM; Piwnica-Worms, H; Samuel, ELG; Taniguchi, CM; Tour, JM	1

Reviews

9 review(s) available for amifostine anhydrous and wr 1065

Article	Year
Radioprotectors in treatment therapy to reduce risk in secondary tumor induction. Pharmacology & therapeutics, 1988, Volume: 39, Issue:1-3 Topics: Amifostine; Animals; Cell Transformation, Neoplastic; Humans; Mercaptoethylamines; Neoplasms; Neoplasms, Radiation-Induced; Radiation-Protective Agents	1988
Amifostine: the preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies. Seminars in oncology, 1996, Volume: 23, Issue:4 Suppl 8 Topics: Amifostine; Animals; Antineoplastic Agents; Cells; Combined Modality Therapy; Humans; Mercaptoethylamines; Neoplasms; Premedication	1996
Pharmacokinetic profile of amifostine. Seminars in oncology, 1996, Volume: 23, Issue:4 Suppl 8 Topics: Amifostine; Animals; Humans; Mercaptoethylamines; Radiation-Protective Agents	1996
Radioprotectants: pharmacology and clinical applications of amifostine. Seminars in radiation oncology, 1998, Volume: 8, Issue:4 Suppl 1 Topics: Alkaline Phosphatase; Amifostine; Animals; Antineoplastic Agents; DNA; Free Radical Scavengers; Humans; Mercaptoethylamines; Neoplasms, Radiation-Induced; Neoplasms, Second Primary; Prodrugs; Radiation-Protective Agents; Radiotherapy; Risk Factors	1998
The preclinical basis for broad-spectrum selective cytoprotection of normal tissues from cytotoxic therapies by amifostine. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 7 Topics: Amifostine; Animals; Antineoplastic Agents; Cytoprotection; Drug Evaluation, Preclinical; Humans; Mercaptoethylamines; Neoplasms; Neoplasms, Experimental; Prodrugs; Protective Agents; Radiation-Protective Agents; Tumor Cells, Cultured	1999
Use of amifostine in hematologic malignancies, myelodysplastic syndrome, and acute leukemia. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 7 Topics: Acute Disease; Amifostine; Animals; Apoptosis; Cytoprotection; Hematologic Neoplasms; Hematopoietic Stem Cells; Humans; Leukemia; Mercaptoethylamines; Molecular Structure; Myelodysplastic Syndromes; Protective Agents; Spermidine; Spermine	1999
Preclinical studies on the radioprotective efficacy and pharmacokinetics of subcutaneously administered amifostine. Seminars in oncology, 2002, Volume: 29, Issue:6 Suppl 19 Topics: Amifostine; Animals; Biological Availability; Cytoprotection; Drug Evaluation, Preclinical; Injections, Intravenous; Injections, Subcutaneous; Macaca fascicularis; Mercaptoethylamines; Radiation Injuries; Radiation-Protective Agents; Rats	2002
Amifostine: is there evidence of tumor protection? Seminars in oncology, 2003, Volume: 30, Issue:6 Suppl 18 Topics: Amifostine; Animals; Antineoplastic Agents; Clinical Trials as Topic; Combined Modality Therapy; Dogs; Drug Evaluation, Preclinical; Humans; Mercaptoethylamines; Models, Animal; Neoplasms; Organoplatinum Compounds; Radiation Injuries; Radiation-Protective Agents; Rats; Sarcoma	2003
Effects of dose and schedule on the efficacy of ethyol: preclinical studies. Seminars in oncology, 2003, Volume: 30, Issue:6 Suppl 18 Topics: Amifostine; Animals; Injections, Intravenous; Injections, Subcutaneous; Macaca fascicularis; Mercaptoethylamines; Models, Animal; Mucous Membrane; Radiation Injuries; Radiation-Protective Agents; Rats	2003

Trials

5 trial(s) available for amifostine anhydrous and wr 1065

Article	Year
Pharmacokinetics of amifostine and its metabolites in patients. European journal of cancer (Oxford, England : 1990), 1997, Volume: 33, Issue:9 Topics: Adult; Amifostine; Antineoplastic Agents; Carboplatin; Cisplatin; Disulfides; Drug Therapy, Combination; Female; Half-Life; Humans; Male; Mercaptoethylamines; Middle Aged	1997
Preclinical and clinical aspects on the use of amifostine as chemoprotector in neuroblastoma patients. Medical and pediatric oncology, 2001, Volume: 36, Issue:1 Topics: Adolescent; Amifostine; Animals; Antineoplastic Agents; Bone Marrow Diseases; Carboplatin; Cell Division; Child; Child, Preschool; Cisplatin; Cross-Over Studies; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Interactions; Etoposide; Humans; Ifosfamide; Mercaptoethylamines; Mice; Mice, Nude; Neuroblastoma; Neutropenia; Prodrugs; Safety; Thrombocytopenia; Treatment Failure; Tumor Cells, Cultured; Vincristine; Vomiting; Xenograft Model Antitumor Assays	2001
Phase I trial of a twice-daily regimen of amifostine with ifosfamide, carboplatin, and etoposide chemotherapy in children with refractory carcinoma. Cancer, 2001, Aug-15, Volume: 92, Issue:4 Topics: Adolescent; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Child; Child, Preschool; Drug Administration Schedule; Etoposide; Female; Humans; Ifosfamide; Male; Mercaptoethylamines; Neoplasms; Treatment Failure	2001
A phase I clinical and pharmacology study using amifostine as a radioprotector in dose-escalated whole liver radiation therapy. International journal of radiation oncology, biology, physics, 2012, Aug-01, Volume: 83, Issue:5 Topics: Adult; Aged; Amifostine; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Cholangiocarcinoma; Female; Humans; Liver; Liver Neoplasms; Logistic Models; Male; Maximum Tolerated Dose; Mercaptoethylamines; Middle Aged; Organs at Risk; Prospective Studies; Radiation Dosage; Radiation Injuries; Radiation Tolerance; Radiation-Protective Agents; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Conformal	2012
Feasibility study of the pharmacology of local application of amifostine (WR-2721) to the buccal mucosa in guinea pigs. Pharmacology, 2013, Volume: 91, Issue:5-6 Topics: Administration, Buccal; Amifostine; Animals; Feasibility Studies; Guinea Pigs; Humans; Mercaptoethylamines; Mouth Mucosa; Myocardium; Radiation-Protective Agents; Saliva	2013

Other Studies

87 other study(ies) available for amifostine anhydrous and wr 1065

Article	Year
Two New Faces of Amifostine: Protector from DNA Damage in Normal Cells and Inhibitor of DNA Repair in Cancer Cells. Journal of medicinal chemistry, 2016, Apr-14, Volume: 59, Issue:7 Topics: Alkaline Phosphatase; Amifostine; Comet Assay; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Fibroblasts; Gamma Rays; Histones; Humans; Intracellular Signaling Peptides and Proteins; MCF-7 Cells; Mercaptoethylamines; Microscopy, Fluorescence; Radiation-Protective Agents; Tumor Suppressor p53-Binding Protein 1	2016
A comparative study of the radioprotective effects of cysteamine, WR-2721, and WR-1065 in cultured human cells. Radiation research, 1979, Volume: 77, Issue:2 Topics: Amifostine; Cell Line; Cell Survival; Cysteamine; Diamines; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Mercaptoethylamines; Organothiophosphorus Compounds; Radiation-Protective Agents; Time Factors	1979
Effects of the modulating agent WR2721 and its main metabolites on the formation and stability of cisplatin-DNA adducts in vitro in comparison to the effects of thiosulphate and diethyldithiocarbamate. Biochemical pharmacology, 1992, Mar-03, Volume: 43, Issue:5 Topics: Amifostine; Animals; Buffers; Cisplatin; Ditiocarb; DNA; DNA Adducts; Hydrogen-Ion Concentration; Mercaptoethylamines; Salmon; Thiosulfates	1992
The reversal of cisplatin-protein interactions by the modulating agent WR2721 and its metabolites WR1065 and WR33278. Cancer chemotherapy and pharmacology, 1992, Volume: 29, Issue:6 Topics: Amifostine; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Cisplatin; Ditiocarb; Drug Interactions; Drug Stability; Fumarate Hydratase; Glutathione; Kinetics; Mercaptoethylamines; Radiation-Protective Agents; Spectrophotometry, Ultraviolet	1992
Characterization of ethiofos absorption in the rat small intestine. Biopharmaceutics & drug disposition, 1991, Volume: 12, Issue:4 Topics: Alkaline Phosphatase; Amifostine; Animals; Buffers; Chromatography, High Pressure Liquid; Duodenum; Intestinal Absorption; Intestine, Small; Intubation, Gastrointestinal; Macaca mulatta; Male; Mercaptoethylamines; Perfusion; Permeability; Pharmaceutic Aids; Rats; Rats, Inbred Strains	1991
The chemical reactivity of the modulating agent WR2721 (ethiofos) and its main metabolites with the antitumor agents cisplatin and carboplatin. Biochemical pharmacology, 1991, Nov-06, Volume: 42, Issue:11 Topics: Amifostine; Carboplatin; Cisplatin; Drug Administration Schedule; Drug Interactions; Kinetics; Mercaptoethylamines; Radiation-Protective Agents	1991
The effect of the radioprotector WR-2721 and WR-1065 on mitochondrial lipid peroxidation. International journal of radiation biology, 1990, Volume: 57, Issue:3 Topics: Amifostine; Animals; Benzene Derivatives; Free Radicals; Glutathione; Glutathione Reductase; In Vitro Techniques; Isocitrate Dehydrogenase; Lipid Peroxidation; Male; Mercaptoethylamines; Mice; Mitochondria, Liver; Organothiophosphorus Compounds; Radiation-Protective Agents; Succinate Dehydrogenase	1990
S-[2-[(2'-carbamoylethyl)amino]ethyl] phosphorothioate and related compounds as potential antiradiation agents. Journal of medicinal chemistry, 1990, Volume: 33, Issue:9 Topics: Amifostine; Animals; Carbamates; Chemical Phenomena; Chemistry; Lethal Dose 50; Mercaptoethylamines; Mice; Organothiophosphates; Organothiophosphorus Compounds; Radiation-Protective Agents; Structure-Activity Relationship	1990
Protection from cellular oxidative injury and calcium intrusion by N-(2-mercaptoethyl)-1,3-propanediamine, WR 1065. Biochemical pharmacology, 1990, Oct-01, Volume: 40, Issue:7 Topics: Amifostine; Animals; Calcium; Cell Line; Cell Survival; Cytochrome c Group; Cytosol; Free Radical Scavengers; Hydrogen Peroxide; Mercaptoethylamines; Oxidation-Reduction; Radiation-Protective Agents; Superoxides	1990
Intraduodenal administration of ethiofos (WR-2721): dose proportionality study in the rhesus monkey. Research communications in chemical pathology and pharmacology, 1989, Volume: 65, Issue:2 Topics: Amifostine; Animals; Biological Availability; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Duodenum; Humans; Intubation, Gastrointestinal; Macaca mulatta; Mercaptoethylamines; Organothiophosphorus Compounds	1989
Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake. Radiation research, 1988, Volume: 114, Issue:2 Topics: Amifostine; Animals; Brain; Cobalt Radioisotopes; Gamma Rays; Guinea Pigs; Hypothermia; Male; Mercaptoethylamines; Organothiophosphorus Compounds; Oxygen Consumption; Radiation Injuries, Experimental; Radiation-Protective Agents	1988
Radioprotection of mouse jejunum by WR-2721 and WR-1065: effects on DNA strand-break induction and rejoining. Radiation research, 1988, Volume: 114, Issue:2 Topics: Amifostine; Animals; Cesium Radioisotopes; Cricetinae; DNA; DNA Repair; Gamma Rays; Jejunum; Mercaptoethylamines; Mice; Mice, Inbred C3H; Organothiophosphorus Compounds; Radiation Injuries, Experimental; Radiation-Protective Agents; Specific Pathogen-Free Organisms	1988
Uptake of WR-2721 derivatives by cells in culture: identification of the transported form of the drug. Cancer research, 1988, Jul-01, Volume: 48, Issue:13 Topics: Amifostine; Biological Transport; Biotransformation; Disulfides; Humans; In Vitro Techniques; Kinetics; Mercaptoethylamines; Organothiophosphorus Compounds; Radiation-Protective Agents; Temperature; Tumor Cells, Cultured	1988
Radioprotection of cells in culture by WR-2721 and derivatives: form of the drug responsible for protection. Cancer research, 1988, Jul-01, Volume: 48, Issue:13 Topics: Alkaline Phosphatase; Amifostine; Animals; Cell Line; Cell Survival; Cricetinae; Cytoplasm; Disulfides; Extracellular Space; Hydrogen-Ion Concentration; Mercaptoethylamines; Organothiophosphorus Compounds; Radiation-Protective Agents; Structure-Activity Relationship	1988
Thermospray liquid chromatography mass spectrometry of thiol radioprotective agents: characteristic spectra. Pharmacology & therapeutics, 1988, Volume: 39, Issue:1-3 Topics: Amifostine; Chromatography, Liquid; Glutathione; Mass Spectrometry; Mercaptoethylamines; Radiation-Protective Agents	1988
Mechanisms of synergistic toxicity of the radioprotective agent, WR2721, and 6-hydroxydopamine. Biochemical pharmacology, 1988, May-01, Volume: 37, Issue:9 Topics: Acetylcysteine; Amifostine; Animals; Catalase; Drug Synergism; Eating; Free Radicals; Glutamate-Cysteine Ligase; Glutathione; Hydroxydopamines; Magnesium; Mercaptoethylamines; Mice; Mice, Inbred A; Organothiophosphorus Compounds; Oxidopamine; Peptide Synthases; Superoxide Dismutase; Time Factors	1988
Alkaline phosphatase promotes radioprotection and accumulation of WR-1065 in V79-171 cells incubated in medium containing WR-2721. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1985, Volume: 47, Issue:1 Topics: Alkaline Phosphatase; Amifostine; Animals; Cell Line; Cell Survival; Cesium Radioisotopes; Cricetinae; Cricetulus; Gamma Rays; In Vitro Techniques; Mercaptoethylamines; Organothiophosphorus Compounds; Radiation-Protective Agents	1985
Some electrostatic aspects of the interaction between DNA or lipids and WR-2721 or its metabolite WR-1065. Progress in clinical and biological research, 1985, Volume: 172A Topics: Amifostine; Chemical Phenomena; Chemistry, Physical; DNA; Electricity; Mercaptoethylamines; Organothiophosphorus Compounds; Phosphatidylcholines	1985
Measurement of WR-2721, WR-1065, and WR-33278 in plasma. International journal of radiation oncology, biology, physics, 1985, Volume: 11, Issue:6 Topics: Adult; Amifostine; Animals; Female; Humans; Male; Mercaptoethylamines; Methods; Organothiophosphorus Compounds; Radiation-Protective Agents; Rats; Rats, Inbred F344	1985
Cystine depletion by WR-1065 in cystinotic cells. Mechanism of action. Biochemical pharmacology, 1985, Jun-15, Volume: 34, Issue:12 Topics: Amifostine; Child; Child, Preschool; Cysteamine; Cystine; Cystinosis; Humans; In Vitro Techniques; Mercaptoethylamines; Radiation-Protective Agents; Sulfur Radioisotopes	1985
Equilibrium dialysis studies of the binding of radioprotector compounds to DNA. Radiation research, 1986, Volume: 107, Issue:2 Topics: Amifostine; DNA; Mercaptoethylamines; Radiation-Protective Agents	1986
Modification of WR-2721 toxicity and radioprotection by an inhibitor of alkaline phosphatase. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:8 Topics: Alkaline Phosphatase; Amifostine; Animals; Biotransformation; Levamisole; Mercaptoethylamines; Mice; Organothiophosphorus Compounds; Radiation-Protective Agents	1986
A method for the combined measurement of ethiofos and WR-1065 in plasma: application to pharmacokinetic experiments with ethiofos and its metabolites. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:8 Topics: Amifostine; Animals; Dogs; Kinetics; Macaca mulatta; Mercaptoethylamines; Methods; Organothiophosphorus Compounds; Tissue Distribution	1986
Human pharmacokinetics of WR-2721. International journal of radiation oncology, biology, physics, 1986, Volume: 12, Issue:8 Topics: Amifostine; Humans; Kinetics; Mercaptoethylamines; Neoplasms; Organothiophosphorus Compounds; Radiation-Protective Agents; Tissue Distribution	1986
Analysis of S-35 labeled WR-2721 and its metabolites in biological fluids. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Amifostine; Animals; Chromatography, High Pressure Liquid; Male; Mercaptoethylamines; Mice; Organothiophosphorus Compounds; Radiation-Protective Agents; Rats; Rats, Inbred F344; Saliva; Submandibular Gland; Sulfur Radioisotopes	1984
Pharmacokinetics of WR-1065 in mouse tissue following treatment with WR-2721. International journal of radiation oncology, biology, physics, 1984, Volume: 10, Issue:9 Topics: Amifostine; Animals; Male; Mercaptoethylamines; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neoplasms, Experimental; Organothiophosphorus Compounds; Radiation-Protective Agents; Time Factors; Tissue Distribution	1984
Studies on the reduction of sputum viscosity in cystic fibrosis using an orally absorbed protected thiol. The Journal of pharmacology and experimental therapeutics, 1980, Volume: 214, Issue:2 Topics: Adolescent; Adult; Amifostine; Animals; Child; Cystic Fibrosis; Diamines; Expectorants; Humans; In Vitro Techniques; Lung; Male; Mercaptoethylamines; Mice; Mice, Inbred BALB C; Organothiophosphorus Compounds; Rabbits; Sputum; Sulfhydryl Compounds; Viscosity	1980
Interaction of sulfur-containing radioprotectors with DNA: a spectrophotometric study. Physiological chemistry and physics, 1980, Volume: 12, Issue:1 Topics: Amifostine; Chemical Phenomena; Chemistry, Physical; Cystaphos; Cysteamine; Diamines; DNA, Bacterial; Escherichia coli; Mercaptoethylamines; Nucleic Acid Denaturation; Radiation-Protective Agents; Spectrophotometry, Ultraviolet	1980
Protein binding of N-2-mercaptoethyl-1,3-diaminopropane via mixed disulfide formation after oral administration of WR 2721. The Journal of pharmacology and experimental therapeutics, 1982, Volume: 220, Issue:2 Topics: Administration, Oral; Amifostine; Animals; Biotransformation; Blood Proteins; Cystic Fibrosis; Diamines; Female; Humans; Mercaptoethylamines; Mucins; Organothiophosphorus Compounds; Protein Binding; Rabbits; Sputum; Sulfhydryl Compounds	1982
Possible association of radioprotective and chemoprotective aminophosphorothioate drug activity with polyamine oxidase susceptibility. Journal of the National Cancer Institute, 1982, Volume: 69, Issue:2 Topics: Amifostine; Antineoplastic Agents; B-Lymphocytes; Cell Survival; Cells, Cultured; Humans; Mercaptoethylamines; Organothiophosphorus Compounds; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Radiation-Protective Agents	1982
Interaction of cultured mammalian cells with WR-2721 and its thiol, WR-1065: implications for mechanisms of radioprotection. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 43, Issue:5 Topics: Amifostine; Calorimetry; Cell Line; Humans; Kidney; Mercaptoethylamines; Organothiophosphorus Compounds; Oxidation-Reduction; Oxygen Consumption; Radiation-Protective Agents	1983
WR-2721, its derivatives and their radioprotective effects on mammalian cells in culture. International journal of radiation biology and related studies in physics, chemistry, and medicine, 1983, Volume: 44, Issue:1 Topics: Aged; Amifostine; Animals; Cell Survival; HeLa Cells; Humans; In Vitro Techniques; Kidney; L Cells; Liver; Lung; Male; Mercaptoethylamines; Mice; Organothiophosphorus Compounds; Radiation-Protective Agents	1983
Protection of cultured mammalian cells by S-2-(3-aminopropylamino)ethylphosphorothioic acid(WR-2721). International journal of radiation oncology, biology, physics, 1983, Volume: 9, Issue:10 Topics: Amifostine; Animals; Cells, Cultured; Cobalt Radioisotopes; Cysteamine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Leukemia L5178; Leukemia, Experimental; Liver; Mercaptoethylamines; Mice; Organothiophosphorus Compounds; Radiation-Protective Agents; Time Factors; Tissue Extracts	1983
Thiol-disulfide interchange between cystine and N-2-mercaptoethyl-1, 3-diaminopropane as a potential treatment for cystinuria. Analytical biochemistry, 1984, Volume: 136, Issue:1 Topics: Amifostine; Amino Acids; Cystine; Cystinuria; Humans; Hydrogen-Ion Concentration; Mercaptoethylamines; Organothiophosphorus Compounds; Oxidation-Reduction	1984
Degradation of 2-(3-aminopropylamino)-ethanethiol (WR-1065) by Cu-dependent amine oxidases and influence on glutathione status of Chinese hamster ovary cells. Biochemical pharmacology, 1995, Aug-08, Volume: 50, Issue:4 Topics: Acrolein; Amifostine; Amine Oxidase (Copper-Containing); Animals; Cell Survival; CHO Cells; Copper; Cricetinae; Culture Media; Cysteamine; Glutathione; Guanidines; Hydrogen Peroxide; Mercaptoethylamines; Oxidoreductases Acting on CH-NH Group Donors; Radiation-Protective Agents; Spermidine	1995
Early hydrogen peroxide-induced pulmonary endothelial cell dysfunction: detection and prevention. Critical care medicine, 1994, Volume: 22, Issue:1 Topics: Amifostine; Animals; Endothelium; Hydrogen Peroxide; Lung Diseases; Male; Mercaptoethylamines; Perfusion; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley	1994
Hypotensive mechanisms of amifostine. Journal of clinical pharmacology, 1996, Volume: 36, Issue:4 Topics: Adrenergic Agents; Amifostine; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Calcium; Cyclic AMP; Cyclic GMP; Ephedrine; Hypotension; In Vitro Techniques; Ligands; Male; Mercaptoethylamines; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Radiation-Protective Agents; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha	1996
Amifostine protects primitive hematopoietic progenitors against chemotherapy cytotoxicity. Seminars in oncology, 1996, Volume: 23, Issue:4 Suppl 8 Topics: Amifostine; Antineoplastic Agents; Bone Marrow Cells; Cells, Cultured; Hematopoietic Stem Cells; Humans; Mercaptoethylamines	1996
Cardioprotection of rat heart myocytes with amifostine (Ethyol) and its free thiol, WR-1065, in vitro. European journal of cancer (Oxford, England : 1990), 1996, Volume: 32A Suppl 4 Topics: Amifostine; Animals; Antibiotics, Antineoplastic; Cell Culture Techniques; Cell Survival; Dose-Response Relationship, Drug; Doxorubicin; Drug Administration Schedule; Female; Heart; Male; Mercaptoethylamines; Rats; Rats, Sprague-Dawley	1996
Pharmacokinetics of amifostine and its metabolites in the plasma and ascites of a cancer patient. Cancer chemotherapy and pharmacology, 1996, Volume: 39, Issue:1-2 Topics: Adenocarcinoma; Amifostine; Ascites; Chromatography, High Pressure Liquid; Disulfides; Half-Life; Humans; Infusions, Intravenous; Male; Mercaptoethylamines; Middle Aged; Radiation-Protective Agents; Stomach Neoplasms	1996
Thiol WR-1065 and disulphide WR-33278, two metabolites of the drug ethyol (WR-2721), protect DNA against fast neutron-induced strand breakage. International journal of radiation biology, 1997, Volume: 71, Issue:2 Topics: Amifostine; Base Sequence; Circular Dichroism; Computer Simulation; DNA Damage; DNA, Bacterial; Fast Neutrons; Mercaptoethylamines; Models, Molecular; Molecular Sequence Data; Nucleic Acid Conformation; Plasmids; Radiation-Protective Agents	1997
Effects of WR-2721 (amifostine) and its metabolite WR-1065 on the antiproliferative activity of chemotherapeutic agents on neuroblastoma cells in vitro. Anti-cancer drugs, 1997, Volume: 8, Issue:1 Topics: Amifostine; Antineoplastic Agents; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Synergism; Humans; Mercaptoethylamines; Neuroblastoma; Radiation-Protective Agents; Tumor Cells, Cultured	1997
High-performance liquid chromatographic assay using electrochemical detection for the combined measurement of amifostine, WR 1065 and the disulfides in plasma. Journal of chromatography. B, Biomedical sciences and applications, 1997, May-23, Volume: 693, Issue:1 Topics: Amifostine; Chromatography, High Pressure Liquid; Disulfides; Electrochemistry; Humans; Mercaptoethylamines; Radiation-Protective Agents; Reproducibility of Results	1997
Determination of the cytoprotective agent WR-2721 (Amifostine, Ethyol) and its metabolites in human blood using monobromobimane fluorescent labeling and high-performance liquid chromatography. Cancer chemotherapy and pharmacology, 1998, Volume: 42, Issue:5 Topics: Amifostine; Bridged Bicyclo Compounds; Child; Chromatography, High Pressure Liquid; Female; Fluorescent Dyes; Half-Life; Humans; Mercaptoethylamines; Prodrugs; Radiation-Protective Agents	1998
Amifostine modulation of bleomycin-induced lung injury in rodents. Seminars in oncology, 1999, Volume: 26, Issue:2 Suppl 7 Topics: Amifostine; Animals; Antimetabolites, Antineoplastic; Bleomycin; Cricetinae; Cytoprotection; Free Radical Scavengers; Lung; Male; Mercaptoethylamines; Mice; Oxidation-Reduction; Prodrugs; Protective Agents; Pulmonary Fibrosis	1999
In vitro protection from cisplatin-induced neurotoxicity by amifostine and its metabolite WR1065. Journal of neuro-oncology, 1999, Volume: 44, Issue:1 Topics: Amifostine; Animals; Antineoplastic Agents; Cisplatin; Mercaptoethylamines; Neurites; Neuroprotective Agents; Neurotoxins; PC12 Cells; Rats	1999
Measurement of both protein-bound and total S-2-(3-aminopropylamino)ethanethiol (WR-1065) in blood by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 2000, Mar-10, Volume: 739, Issue:2 Topics: Amifostine; Blood Proteins; Chromatography, High Pressure Liquid; Humans; Mercaptoethylamines; Protein Binding; Radiation-Protective Agents; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence	2000
Cytoprotection by WR-1065, the active form of amifostine, is independent of p53 status in human malignant glioma cell lines. International journal of radiation biology, 2000, Volume: 76, Issue:5 Topics: Amifostine; Cell Survival; Cytoprotection; Dose-Response Relationship, Radiation; Genes, p53; Glioma; Humans; Mercaptoethylamines; Mutation; Radiation-Protective Agents; Tumor Cells, Cultured; Tumor Suppressor Protein p53	2000
Amifostine: a tonic or toxin to myeloid progenitors. Leukemia research, 2000, Volume: 24, Issue:12 Topics: Amifostine; Animals; Antineoplastic Agents; Apoptosis; Cell Survival; Humans; Leukemia, Myeloid; Mercaptoethylamines; Myeloid Progenitor Cells; Radiation-Protective Agents	2000
Selective radioprotection of hepatocytes by systemic and portal vein infusions of amifostine in a rat liver tumor model. International journal of radiation oncology, biology, physics, 2001, Jun-01, Volume: 50, Issue:2 Topics: Amifostine; Analysis of Variance; Animals; Hepatocytes; Infusions, Intravenous; Liver Neoplasms, Experimental; Male; Mercaptoethylamines; Micronucleus Tests; Portal Vein; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley	2001
Role of endogenous thiols in protection. Advances in space research : the official journal of the Committee on Space Research (COSPAR), 1992, Volume: 12, Issue:2-3 Topics: Amifostine; Animals; Cells; Cysteamine; DNA Damage; DNA Repair; Free Radical Scavengers; Glutathione; Humans; Mercaptoethylamines; Prostaglandins; Radiation Injuries; Radiation Tolerance; Radiation-Protective Agents; Radiation, Ionizing; Sulfhydryl Compounds	1992
Blood thiols following amifostine and mesna infusions, a pediatric oncology group study. Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:11 Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Child; Chromatography, High Pressure Liquid; Disulfides; Female; Humans; Infusions, Intravenous; Leukocytes, Mononuclear; Male; Mercaptoethylamines; Mesna; Protective Agents; Radiation-Protective Agents; Sarcoma, Ewing; Sulfhydryl Compounds	2001
Amifostine does not inhibit the toxic effects of anthracycline derivates or mitoxantrone on MDR tumor cell lines. Leukemia & lymphoma, 2001, Volume: 42, Issue:4 Topics: Amifostine; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Division; Cytoprotection; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance, Multiple; Humans; Mercaptoethylamines; Mitoxantrone; Radiation-Protective Agents; Tumor Cells, Cultured	2001
Inhibition of spontaneous metastases formation by amifostine. International journal of cancer, 2002, Jan-10, Volume: 97, Issue:2 Topics: Amifostine; Angiostatins; Animals; Blotting, Western; Cell Division; Dose-Response Relationship, Drug; Lung Neoplasms; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mercaptoethylamines; Mice; Mice, Inbred C3H; Muscle Neoplasms; Neoplasm Invasiveness; Peptide Fragments; Plasminogen; Radiation-Protective Agents; Sarcoma, Experimental; Xenograft Model Antitumor Assays	2002
Relationships between cytoprotection and mutation prevention by WR-1065. Military medicine, 2002, Volume: 167, Issue:2 Suppl Topics: Amifostine; Animals; CHO Cells; Cricetinae; Humans; Mercaptoethylamines; Mutation; Radiation-Protective Agents	2002
Enhancement of fotemustine (Muphoran) cytotoxicity by amifostine in malignant melanoma cell lines. Anti-cancer drugs, 2002, Volume: 13, Issue:2 Topics: Amifostine; Antineoplastic Agents; Cell Survival; Drug Synergism; Humans; Inhibitory Concentration 50; Melanoma; Mercaptoethylamines; Nitrosourea Compounds; O(6)-Methylguanine-DNA Methyltransferase; Organophosphorus Compounds; Radiation-Protective Agents; Tumor Cells, Cultured	2002
Differential activation of nuclear transcription factor kappaB, gene expression, and proteins by amifostine's free thiol in human microvascular endothelial and glioma cells. Seminars in radiation oncology, 2002, Volume: 12, Issue:1 Suppl 1 Topics: Amifostine; Cell Adhesion Molecules; Cells, Cultured; Endothelium, Vascular; Gene Expression; Glioma; Growth Substances; Humans; Mercaptoethylamines; Monokines; NF-kappa B; Radiation Dosage; Radiation-Protective Agents; Superoxide Dismutase; Transcriptional Activation; Tumor Cells, Cultured	2002
Lens epithelial cell protection by aminothiol WR-1065 and anetholedithiolethione from ionizing radiation. International journal of cancer, 2001, Volume: 96 Suppl Topics: Amifostine; Anethole Trithione; Animals; Apoptosis; Benzimidazoles; Cattle; Cell Death; Cell Membrane; Cell Nucleus; Cell Survival; Cells, Cultured; Dose-Response Relationship, Radiation; Epithelial Cells; Flow Cytometry; Glutathione; Lens, Crystalline; Mercaptoethylamines; Microscopy, Fluorescence; Radiation-Protective Agents; Spectrometry, Fluorescence; Time Factors; Ultraviolet Rays; X-Rays	2001
Selective exclusion by the polyamine transporter as a mechanism for differential radioprotection of amifostine derivatives. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:5 Topics: Amifostine; Biological Transport; Cell Survival; Dose-Response Relationship, Drug; Eflornithine; Gene Expression; Humans; Mercaptoethylamines; Ornithine Decarboxylase Inhibitors; Polyamines; Proteins; Radiation-Protective Agents; Transfection; Tumor Cells, Cultured	2002
New liquid chromatographic assay with electrochemical detection for the measurement of amifostine and WR1065. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2002, Jun-05, Volume: 772, Issue:2 Topics: Amifostine; Chromatography, High Pressure Liquid; Electrochemistry; Humans; Mercaptoethylamines; Reproducibility of Results; Sensitivity and Specificity	2002
Activation of the nuclear transcription factor kappaB (NFkappaB) and differential gene expression in U87 glioma cells after exposure to the cytoprotector amifostine. International journal of radiation oncology, biology, physics, 2002, May-01, Volume: 53, Issue:1 Topics: Amifostine; Chemokine CCL5; Gene Expression Regulation; Genes, myb; Genes, myc; Glioma; Glutathione Transferase; Humans; Interleukin-2 Receptor alpha Subunit; Mercaptoethylamines; NF-kappa B; Oxidation-Reduction; Radiation-Protective Agents; Radiobiology; Receptors, Interleukin; Superoxide Dismutase; Tumor Cells, Cultured	2002
A pilot study of topical intrarectal application of amifostine for prevention of late radiation rectal injury. International journal of radiation oncology, biology, physics, 2002, Aug-01, Volume: 53, Issue:5 Topics: Adenocarcinoma; Administration, Topical; Amifostine; Analysis of Variance; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Humans; Intestinal Mucosa; Male; Mercaptoethylamines; Multivariate Analysis; Prostatic Neoplasms; Radiation-Protective Agents; Rectum; Telangiectasis; Time Factors	2002
Inhibition of LPS-induced nitric oxide production in RAW cells by radioprotective thiols. Experimental and molecular pathology, 2003, Volume: 74, Issue:1 Topics: Acetylcysteine; Amifostine; Animals; Cell Line; Cysteine; Disulfiram; Dithiothreitol; Lipopolysaccharides; Macrophages; Mercaptoethylamines; Mice; Nitric Oxide; Radiation-Protective Agents; Sulfhydryl Compounds	2003
Subcutaneous administration of amifostine (ethyol) is equivalent to intravenous administration in a rat mucositis model. International journal of radiation oncology, biology, physics, 2003, Nov-01, Volume: 57, Issue:3 Topics: Amifostine; Animals; Female; Injections, Intravenous; Injections, Subcutaneous; Mercaptoethylamines; Models, Animal; Mouth Mucosa; Radiation Injuries; Radiation-Protective Agents; Rats; Rats, Sprague-Dawley; Stomatitis; Xerostomia	2003
Disposition of WR-1065 in the liver of tumor-bearing rats following regional vs systemic administration of amifostine. Biopharmaceutics & drug disposition, 2004, Volume: 25, Issue:1 Topics: Amifostine; Animals; Antineoplastic Agents; Carcinoma 256, Walker; Disease Models, Animal; Drug Delivery Systems; Drug Screening Assays, Antitumor; Femoral Vein; Infusions, Intravenous; Liver Neoplasms, Experimental; Male; Mercaptoethylamines; Neoplasm Transplantation; Portal Vein; Prodrugs; Rats; Rats, Sprague-Dawley	2004
Comparative study between the interaction of dephosphorylated amifostine (WR-1065) and amoxicilline with pBR322 in absence and presence of cisplatin by AFM. International journal of pharmaceutics, 2004, Feb-11, Volume: 270, Issue:1-2 Topics: Amifostine; Amoxicillin; Antineoplastic Agents; Cisplatin; DNA; Mercaptoethylamines; Microscopy, Atomic Force; Plasmids; Solvents	2004
The radioprotective agent, amifostine, suppresses the reactivity of intralysosomal iron. Redox report : communications in free radical research, 2003, Volume: 8, Issue:6 Topics: Amifostine; Animals; Apoptosis; Caspases; Cell Line; Cell Membrane; DNA; Electron Spin Resonance Spectroscopy; Endocytosis; Enzyme Activation; Hydrogen Peroxide; Hydrogen-Ion Concentration; Iron; Lysosomes; Mercaptoethylamines; Mice; Models, Biological; Models, Chemical; Oxidants; Phosphates; Phosphorylation; Protons; Radiation-Protective Agents; Sulfhydryl Compounds	2003
Interaction of amifostine and ionizing radiation on transcriptional patterns of apoptotic genes expressed in human microvascular endothelial cells (HMEC). International journal of radiation oncology, biology, physics, 2004, Oct-01, Volume: 60, Issue:2 Topics: Amifostine; Apoptosis; Cell Cycle; Cell Survival; Endothelial Cells; Endothelium, Vascular; Gene Expression Profiling; Humans; Mercaptoethylamines; Radiation-Protective Agents; ROC Curve; Transcription, Genetic	2004
Tissue levels of WR-1065, the active metabolite of amifostine (Ethyol), are equivalent following intravenous or subcutaneous administration in cynomolgus monkeys. Oncology, 2004, Volume: 67, Issue:3-4 Topics: Amifostine; Animals; Biological Availability; Half-Life; Infusions, Intravenous; Injections, Subcutaneous; Macaca fascicularis; Mercaptoethylamines; Radiation-Protective Agents; Tissue Distribution	2004
Delayed radioprotection by NFkappaB-mediated induction of Sod2 (MnSOD) in SA-NH tumor cells after exposure to clinically used thiol-containing drugs. Radiation research, 2004, Volume: 162, Issue:5 Topics: Acetylcysteine; Amifostine; Angiotensin-Converting Enzyme Inhibitors; Animals; Blotting, Western; Captopril; Cell Line, Tumor; Cell Survival; DNA Damage; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; I-kappa B Proteins; Mercaptoethylamines; Mesna; Mice; Mutation; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Plasmids; Protective Agents; Radiation-Protective Agents; Serine; Sulfhydryl Compounds; Superoxide Dismutase; Time Factors; Transfection	2004
Amifostine (ETHYOL) protects rats from mucositis resulting from fractionated or hyperfractionated radiation exposure. International journal of radiation oncology, biology, physics, 2005, Mar-01, Volume: 61, Issue:3 Topics: Amifostine; Animals; Dose Fractionation, Radiation; Drug Evaluation, Preclinical; Female; Injections, Intravenous; Injections, Subcutaneous; Mammary Neoplasms, Experimental; Mercaptoethylamines; Mouth Mucosa; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Stomatitis; Tissue Distribution	2005
Determination of WR-1065 in human blood by high-performance liquid chromatography following fluorescent derivatization by a maleimide reagent ThioGlo3. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005, May-05, Volume: 819, Issue:1 Topics: Amifostine; Chromatography, High Pressure Liquid; Drug Stability; Humans; Liver Neoplasms; Mercaptoethylamines; Pyrans; Pyrroles; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Fluorescence	2005
Effect of amifostine on the cytotoxicity of daunorubicin and daunoxome in tumor and normal cells. Cancer chemotherapy and pharmacology, 2006, Volume: 57, Issue:4 Topics: Amifostine; Antibiotics, Antineoplastic; Apoptosis; Cell Survival; Cells, Cultured; Chemistry, Pharmaceutical; Daunorubicin; Drug Carriers; Hematopoietic Stem Cells; Humans; Liposomes; Lymphocytes; Mercaptoethylamines; Radiation-Protective Agents; Tumor Cells, Cultured; Tumor Stem Cell Assay	2006
Manganese superoxide dismutase (SOD2)-mediated delayed radioprotection induced by the free thiol form of amifostine and tumor necrosis factor alpha. Radiation research, 2007, Volume: 167, Issue:4 Topics: Amifostine; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Humans; Mercaptoethylamines; Radiation Tolerance; Radiation-Protective Agents; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2007
WR-1065, the active metabolite of amifostine, mitigates radiation-induced delayed genomic instability. Free radical biology & medicine, 2008, Dec-15, Volume: 45, Issue:12 Topics: Amifostine; Cell Line, Tumor; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Radiation; Genomic Instability; Green Fluorescent Proteins; Humans; Mercaptoethylamines; Micronucleus Tests; Radiation Tolerance; Radiation-Protective Agents; Superoxide Dismutase; X-Rays	2008
Amifostine induces antioxidant enzymatic activities in normal tissues and a transplantable tumor that can affect radiation response. International journal of radiation oncology, biology, physics, 2009, Mar-01, Volume: 73, Issue:3 Topics: Amifostine; Animals; Catalase; Female; Glutathione Peroxidase; Liver; Lung; Mercaptoethylamines; Mice; Mice, Inbred C3H; Myocardium; Pancreas; Radiation Tolerance; Radiation-Protective Agents; Sarcoma, Experimental; Superoxide Dismutase	2009
Evaluation of new thiadiazoles and benzothiazoles as potential radioprotectors: free radical scavenging activity in vitro and theoretical studies (QSAR, DFT). Free radical biology & medicine, 2009, Apr-15, Volume: 46, Issue:8 Topics: Amifostine; Bacteria; Benzothiazoles; Biphenyl Compounds; DNA Damage; DNA, Bacterial; Drug Evaluation, Preclinical; Free Radical Scavengers; Hydroxyl Radical; Mercaptoethylamines; Models, Theoretical; Neural Networks, Computer; Oxidative Stress; Picrates; Quantitative Structure-Activity Relationship; Radiation-Protective Agents; Radiation, Ionizing; Sulfonic Acids; Thiadiazoles; Thiazoles	2009
Amifostine metabolite WR-1065 disrupts homologous recombination in mammalian cells. Radiation research, 2010, Volume: 173, Issue:2 Topics: Amifostine; Animals; Camptothecin; Cell Line, Tumor; CHO Cells; Cricetinae; Cricetulus; DNA-Binding Proteins; Genomic Instability; Humans; Hydroxyurea; Mercaptoethylamines; Rad51 Recombinase; Radiation-Protective Agents; Reactive Oxygen Species; Recombination, Genetic; RNA Interference	2010
Clinical pharmacokinetics of amifostine and WR1065 in pediatric patients with medulloblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 2010, Feb-01, Volume: 16, Issue:3 Topics: Adolescent; Adult; Amifostine; Antineoplastic Combined Chemotherapy Protocols; Cerebellar Neoplasms; Child; Combined Modality Therapy; Female; Humans; Male; Medulloblastoma; Mercaptoethylamines; Prodrugs	2010
SOD2-mediated adaptive responses induced by low-dose ionizing radiation via TNF signaling and amifostine. Free radical biology & medicine, 2011, Nov-15, Volume: 51, Issue:10 Topics: Amifostine; Animals; Cell Line, Tumor; Enzyme Activation; Mercaptoethylamines; Mice; Micronuclei, Chromosome-Defective; Micronucleus Tests; Radiation, Ionizing; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Small Interfering; Signal Transduction; Superoxide Dismutase; Tumor Necrosis Factor-alpha	2011
Ion-pair strategy for enabling amifostine oral absorption: rat in situ and in vivo experiments. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2013, Jul-16, Volume: 49, Issue:4 Topics: Administration, Oral; Amifostine; Animals; Benzoic Acid; Biological Availability; Intestinal Absorption; Intestine, Small; Male; Mercaptoethylamines; Perfusion; Phthalic Acids; Prodrugs; Radiation-Protective Agents; Rats; Rats, Wistar; Succinic Acid	2013
Ranking the Binding Energies of p53 Mutant Activators and Their ADMET Properties. Chemical biology & drug design, 2015, Volume: 86, Issue:2 Topics: Alkylation; Amifostine; Aza Compounds; Bridged Bicyclo Compounds, Heterocyclic; Drug Evaluation, Preclinical; Ellipticines; Heterocyclic Compounds, 4 or More Rings; Humans; Kinetics; Ligands; Mercaptoethylamines; Molecular Dynamics Simulation; Mutagenesis, Site-Directed; Mutation; Oxepins; Protein Binding; Pyrimidines; Quinuclidines; Tumor Suppressor Protein p53	2015
CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice. Health physics, 2015, Volume: 109, Issue:3 Topics: Acute Radiation Syndrome; Amifostine; Animals; Disease Models, Animal; Dose-Response Relationship, Radiation; Male; Mercaptoethylamines; Mice; Mice, Inbred C57BL; Micelles; Polyethylene Glycols; Radiation-Protective Agents; Whole-Body Irradiation	2015
Ultrasensitive detection of amifostine and alkaline phosphatase based on the growth of CdS quantum dots. Talanta, 2015, Nov-01, Volume: 144 Topics: Alkaline Phosphatase; Amifostine; Cadmium Compounds; Humans; Hydrolysis; Limit of Detection; Mercaptoethylamines; Nanotechnology; Phosphoric Acids; Phosphorylation; Quantum Dots; Spectrometry, Fluorescence; Sulfides; Time Factors	2015
Novel Formulation Strategy to Improve the Feasibility of Amifostine Administration. Pharmaceutical research, 2018, Mar-19, Volume: 35, Issue:5 Topics: Administration, Intravenous; Administration, Oral; Amifostine; Animals; Biological Availability; Cell Line; Head and Neck Neoplasms; Humans; Injections, Subcutaneous; Jejunum; Male; Mercaptoethylamines; Osteoblasts; Osteogenesis; Radiation Injuries, Experimental; Radiation-Protective Agents; Rats; Skull; Treatment Outcome	2018
Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection. Journal of dental research, 2018, Volume: 97, Issue:11 Topics: Acinar Cells; Amifostine; Animals; Female; Fluorescent Antibody Technique; Injections; Mercaptoethylamines; Mice; Mice, Inbred C57BL; Radiation Injuries, Experimental; Radiation-Protective Agents; Salivary Glands; Submandibular Gland	2018
Enteral Activation of WR-2721 Mediates Radioprotection and Improved Survival from Lethal Fractionated Radiation. Scientific reports, 2019, 02-13, Volume: 9, Issue:1 Topics: Administration, Oral; Amifostine; Animals; Female; Intestine, Small; Male; Mercaptoethylamines; Mice; Mice, Inbred C57BL; Pancreatic Neoplasms; Radiation Dosage; Radiation Protection; Radiation-Protective Agents	2019