amicoumacin-a and lipoamide

Four novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.

Topics: Anti-Bacterial Agents; Aquatic Organisms; Bacillus subtilis; Coumarins; Drug Discovery; Fermentation; Gram-Negative Bacteria; Gram-Positive Bacteria; HeLa Cells; Humans; Indian Ocean; Inhibitory Concentration 50; Microbial Sensitivity Tests; Molecular Structure; Proteobacteria; Structure-Activity Relationship; Thioctic Acid