amg531 and pyrazinoic-acid

amg531 has been researched along with pyrazinoic-acid* in 1 studies

Other Studies

1 other study(ies) available for amg531 and pyrazinoic-acid

Article	Year
The identification of orally bioavailable thrombopoietin agonists. Bioorganic & medicinal chemistry letters, 2009, Mar-01, Volume: 19, Issue:5 Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the development of an oral agent. The physical properties of the series were improved by replacing the aminopyrimidinyl group with a piperidine-4-carboxylic acid moiety. The resulting compounds possessed favorable in vivo pharmacokinetic properties, including good bioavailability. Topics: Administration, Oral; Animals; Benzoates; Biological Availability; Caco-2 Cells; Humans; Hydrazines; Piperidines; Pyrazinamide; Pyrazoles; Pyrimidines; Rats; Receptors, Thrombopoietin	2009

Article

Year

The identification of orally bioavailable thrombopoietin agonists.

Bioorganic & medicinal chemistry letters, 2009, Mar-01, Volume: 19, Issue:5

Recently, we disclosed a series of potent pyrimidine benzamide-based thrombopoietin receptor agonists. Unfortunately, the structural features required for the desired activity conferred physicochemical properties that were not favorable for the development of an oral agent. The physical properties of the series were improved by replacing the aminopyrimidinyl group with a piperidine-4-carboxylic acid moiety. The resulting compounds possessed favorable in vivo pharmacokinetic properties, including good bioavailability.

Topics: Administration, Oral; Animals; Benzoates; Biological Availability; Caco-2 Cells; Humans; Hydrazines; Piperidines; Pyrazinamide; Pyrazoles; Pyrimidines; Rats; Receptors, Thrombopoietin

2009