amentoflavone and 1-1-diphenyl-2-picrylhydrazyl

amentoflavone has been researched along with 1-1-diphenyl-2-picrylhydrazyl* in 1 studies

Other Studies

1 other study(ies) available for amentoflavone and 1-1-diphenyl-2-picrylhydrazyl

ArticleYear
Bioactive benzophenones from Garcinia xanthochymus fruits.
    Journal of natural products, 2005, Volume: 68, Issue:3

    A MeOH extract of Garcinia xanthochymus fruits was subjected to activity-guided fractionation, yielding two new benzophenones, guttiferone H (1) and gambogenone (2). Compound 1 contains a seven-membered ring attached to the bicyclo[3.3.1]nonane system at positions 7 and 8 and displayed cytotoxicity in the SW-480 colon cancer cell line (IC(50) = 12 microM). Compound 2 has a novel benzophenone bicyclo[3.3.2]decane system and displayed cytotoxicity in the SW-480 colon cancer cell line (IC(50) = 188 microM). Both 1 and 2 induced apoptosis in SW-480 colon cancer cells and displayed antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay (IC(50) = 64 and 38.7 microM, respectively). The structures of 1 and 2 were established by 1D and 2D NMR data analysis. Eleven known compounds, aristophenone A, alloathyriol, amentoflavone, 3,8' '-biapigenin, cycloxanthochymol, (+/-)-fukugetin, (+/-)-fukugiside, guttiferone E, isoxanthochymol, (+/-)-volkensiflavone, and xanthochymol, were also obtained. The 11 known compounds were also tested against SW-480 colon cancer cells and in the DPPH assay.

    Topics: Antineoplastic Agents, Phytogenic; Antioxidants; Benzophenones; Biphenyl Compounds; Drug Screening Assays, Antitumor; Florida; Fruit; Garcinia; Humans; Molecular Structure; Picrates; Plants, Medicinal; Tumor Cells, Cultured

2005