Compounds > amdoxovir
Page last updated: 2024-09-03

amdoxovir and guanosine

amdoxovir has been researched along with guanosine in 9 studies

Compound Research Comparison

Studies
(amdoxovir)		Trials
(amdoxovir)		Recent Studies (post-2010)
(amdoxovir)		Studies
(guanosine)		Trials
(guanosine)		Recent Studies (post-2010) (guanosine)
33524,442261,036

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (22.22)18.2507
2000's7 (77.78)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boudinot, FD; Chu, CK; Gao, Z; McClure, HM; Rajagopalan, P; Schinazi, RF1
Boudinot, FD; Chen, H; Chu, CK; Gao, Z; McClure, HM; Rajagopalan, P; Schinazi, RF1
Anderson, KS; Borroto-Esoda, K; Chu, CK; Copeland, WC; Feng, JY; Furman, PA; Hill, E; Jeffrey, J; Kiefer, LL; Liberman, I; Painter, GR; Schinazi, RF; Sommadossi, JP1
Borroto-Esoda, K; Harris, JL; Hooper, BJ; McCreedy, B; Mewshaw, JP; Myrick, FT; Wakefield, DA1
Furman, P; Martin, P; Pichoud, C; Seignères, B; Trépo, C; Zoulim, F1
Borroto-Esoda, K; Chong, Y; Chu, CK; Furman, PA; Schinazi, RF1
Back, DJ; Hart, R; Hoggard, PG; Kewn, S; Khoo, SH; MacNeela, JP; Rousseau, F; Wang, LH1
Borroto-Esoda, K; Cheng, YC; Deville-Bonne, D; Feng, JY; Krajewski, ML; Krishnan, P; Parker, WB; Veron, M1
Chu, CK; Narayanasamy, J; Pullagurla, MR; Schinazi, RF; Sharon, A; Wang, J1

Other Studies

9 other study(ies) available for amdoxovir and guanosine

ArticleYear
High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection.
    Journal of chromatography. B, Biomedical applications, 1995, Oct-06, Volume: 672, Issue:1

    Topics: Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Dioxolanes; Guanosine; Injections, Intravenous; Macaca mulatta; Male; Purine Nucleosides; Radiochemistry; Reproducibility of Results; Spectrophotometry, Ultraviolet

1995
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys.
    AIDS research and human retroviruses, 1999, Dec-10, Volume: 15, Issue:18

    Topics: Administration, Oral; Animals; Anti-HIV Agents; Antiviral Agents; Biological Availability; Biotransformation; Dioxolanes; Guanosine; Injections, Intravenous; Macaca mulatta; Male; Metabolic Clearance Rate; Molecular Structure; Prodrugs; Purine Nucleosides; Rats; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution

1999
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine.
    Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:1

    Topics: Adenosine Deaminase Inhibitors; Anti-HIV Agents; Bone Marrow Cells; Cells, Cultured; Dioxolanes; DNA, Viral; Drug Resistance, Microbial; Enzyme Inhibitors; Guanosine; HIV-1; Humans; Lactic Acid; Microscopy, Electron; Mitochondria; Nucleic Acid Synthesis Inhibitors; Prodrugs; Purine Nucleosides; Reverse Transcriptase Inhibitors

2001
Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails.
    Journal of acquired immune deficiency syndromes (1999), 2002, Jan-01, Volume: 29, Issue:1

    Topics: Antiviral Agents; Dioxolanes; Drug Resistance, Multiple, Viral; Guanosine; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Point Mutation; Purine Nucleosides; Recombination, Genetic; Reverse Transcriptase Inhibitors

2002
Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses.
    Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:3

    Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Cytidine Triphosphate; Dioxolanes; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; Guanosine; Hepadnaviridae Infections; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Hepatocytes; Humans; Lamivudine; Liver Neoplasms; Mutation; Purine Nucleosides; Reverse Transcriptase Inhibitors; Thiophenes; Tumor Cells, Cultured

2002
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach.
    Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:2

    Topics: Anti-HIV Agents; Binding Sites; Dioxolanes; Drug Resistance; Guanosine; HIV-1; Lamivudine; Models, Molecular; Mutation, Missense; Protein Binding; Purine Nucleosides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Zidovudine

2002
Enzymatic assay for measurement of intracellular DXG triphosphate concentrations in peripheral blood mononuclear cells from human immunodeficiency virus type 1-infected patients.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:1

    Topics: Dioxolanes; Guanosine; HIV Infections; HIV-1; Humans; Purine Nucleosides

2003
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases.
    Biochemical pharmacology, 2004, Nov-01, Volume: 68, Issue:9

    Topics: Antiviral Agents; Dioxolanes; Guanosine; Guanosine Triphosphate; Humans; Phosphorylation; Phosphotransferases; Purine Nucleosides; Tumor Cells, Cultured

2004
Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs.
    Antiviral research, 2007, Volume: 75, Issue:3

    Topics: Animals; Anti-HIV Agents; Cell Line; Dioxolanes; Drug Stability; Guanosine; HIV; HIV Infections; Humans; Leukocytes, Mononuclear; Prodrugs; Purine Nucleosides; Solubility

2007