Page last updated: 2024-09-03

amdoxovir and 2-aminopurine dioxolane

amdoxovir has been researched along with 2-aminopurine dioxolane in 11 studies

Compound Research Comparison

Studies (amdoxovir)	Trials (amdoxovir)	Recent Studies (post-2010) (amdoxovir)	Studies (2-aminopurine dioxolane)	Trials (2-aminopurine dioxolane)	Recent Studies (post-2010) (2-aminopurine dioxolane)
33	5	2	25	1	0

Research

Studies (11)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (18.18)	18.2507
2000's	8 (72.73)	29.6817
2010's	1 (9.09)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Asif, G; Chu, CK; Delinsky, D; Hurwitz, SJ; McClure, HM; Narayanasamy, J; Obikhod, A; Schinazi, RF	1
Asif, G; Butler, SD; Chu, CK; Cote, PJ; George, AL; Gerin, JL; Hurwitz, SJ; Menne, S; Narayanasamy, J; Schinazi, RF; Tennant, BC	1
Asif, G; Fromentin, E; Hurwitz, SJ; Schinazi, RF; Tharnish, PM	1
Boudinot, FD; Chu, CK; Gao, Z; McClure, HM; Rajagopalan, P; Schinazi, RF	1
Boudinot, FD; Chen, H; Chu, CK; Gao, Z; McClure, HM; Rajagopalan, P; Schinazi, RF	1
Anderson, KS; Borroto-Esoda, K; Chu, CK; Copeland, WC; Feng, JY; Furman, PA; Hill, E; Jeffrey, J; Kiefer, LL; Liberman, I; Painter, GR; Schinazi, RF; Sommadossi, JP	1
Borroto-Esoda, K; Harris, JL; Hooper, BJ; McCreedy, B; Mewshaw, JP; Myrick, FT; Wakefield, DA	1
Furman, P; Martin, P; Pichoud, C; Seignères, B; Trépo, C; Zoulim, F	1
Borroto-Esoda, K; Chong, Y; Chu, CK; Furman, PA; Schinazi, RF	1
Borroto-Esoda, K; Cheng, YC; Deville-Bonne, D; Feng, JY; Krajewski, ML; Krishnan, P; Parker, WB; Veron, M	1
Chu, CK; Narayanasamy, J; Pullagurla, MR; Schinazi, RF; Sharon, A; Wang, J	1

Trials

1 trial(s) available for amdoxovir and 2-aminopurine dioxolane

Article	Year
Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals. Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3 Topics: Adult; Anti-HIV Agents; Dioxolanes; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Purine Nucleosides; Reverse Transcriptase Inhibitors; Treatment Outcome; Young Adult; Zidovudine	2010

Article

Year

Lack of pharmacokinetic interaction between amdoxovir and reduced- and standard-dose zidovudine in HIV-1-infected individuals.

Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

Topics: Adult; Anti-HIV Agents; Dioxolanes; Drug Administration Schedule; Drug Interactions; Female; HIV Infections; HIV-1; Humans; Male; Middle Aged; Purine Nucleosides; Reverse Transcriptase Inhibitors; Treatment Outcome; Young Adult; Zidovudine

2010

Other Studies

10 other study(ies) available for amdoxovir and 2-aminopurine dioxolane

Article	Year
Pharmacokinetics of the anti-human immunodeficiency virus agent 1-(beta-D-dioxolane)thymine in rhesus monkeys. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:7 Topics: Administration, Oral; Animals; Antiviral Agents; Area Under Curve; Calibration; Chromatography, High Pressure Liquid; Dioxolanes; Female; Half-Life; HIV-1; Injections, Intravenous; Macaca mulatta; Mass Spectrometry; Metabolic Clearance Rate; Molecular Structure; Reference Standards; Reproducibility of Results; Thymine	2007
Antiviral effect of orally administered (-)-beta-D-2-aminopurine dioxolane in woodchucks with chronic woodchuck hepatitis virus infection. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:9 Topics: Administration, Oral; Animals; Antiviral Agents; Dioxolanes; DNA, Viral; Dose-Response Relationship, Drug; Guanine; Half-Life; Hepatitis B Virus, Woodchuck; Hepatitis B, Chronic; Injections, Intravenous; Marmota; Prodrugs; Purines; Tissue Distribution	2007
High-performance liquid chromatographic determination of (-)-beta-D-2,6-diaminopurine dioxolane and its metabolite, dioxolane guanosine, using ultraviolet and on-line radiochemical detection. Journal of chromatography. B, Biomedical applications, 1995, Oct-06, Volume: 672, Issue:1 Topics: Animals; Antiviral Agents; Chromatography, High Pressure Liquid; Dioxolanes; Guanosine; Injections, Intravenous; Macaca mulatta; Male; Purine Nucleosides; Radiochemistry; Reproducibility of Results; Spectrophotometry, Ultraviolet	1995
Pharmacokinetics of (-)-beta-D-dioxolane guanine and prodrug (-)-beta-D-2,6-diaminopurine dioxolane in rats and monkeys. AIDS research and human retroviruses, 1999, Dec-10, Volume: 15, Issue:18 Topics: Administration, Oral; Animals; Anti-HIV Agents; Antiviral Agents; Biological Availability; Biotransformation; Dioxolanes; Guanosine; Injections, Intravenous; Macaca mulatta; Male; Metabolic Clearance Rate; Molecular Structure; Prodrugs; Purine Nucleosides; Rats; Rats, Sprague-Dawley; Species Specificity; Tissue Distribution	1999
Mechanism of action of 1-beta-D-2,6-diaminopurine dioxolane, a prodrug of the human immunodeficiency virus type 1 inhibitor 1-beta-D-dioxolane guanosine. Antimicrobial agents and chemotherapy, 2001, Volume: 45, Issue:1 Topics: Adenosine Deaminase Inhibitors; Anti-HIV Agents; Bone Marrow Cells; Cells, Cultured; Dioxolanes; DNA, Viral; Drug Resistance, Microbial; Enzyme Inhibitors; Guanosine; HIV-1; Humans; Lactic Acid; Microscopy, Electron; Mitochondria; Nucleic Acid Synthesis Inhibitors; Prodrugs; Purine Nucleosides; Reverse Transcriptase Inhibitors	2001
Dioxolane guanosine, the active form of the prodrug diaminopurine dioxolane, is a potent inhibitor of drug-resistant HIV-1 isolates from patients for whom standard nucleoside therapy fails. Journal of acquired immune deficiency syndromes (1999), 2002, Jan-01, Volume: 29, Issue:1 Topics: Antiviral Agents; Dioxolanes; Drug Resistance, Multiple, Viral; Guanosine; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Point Mutation; Purine Nucleosides; Recombination, Genetic; Reverse Transcriptase Inhibitors	2002
Inhibitory activity of dioxolane purine analogs on wild-type and lamivudine-resistant mutants of hepadnaviruses. Hepatology (Baltimore, Md.), 2002, Volume: 36, Issue:3 Topics: Animals; Arabinofuranosylcytosine Triphosphate; Arabinofuranosyluracil; Carcinoma, Hepatocellular; Cytidine Triphosphate; Dioxolanes; DNA Replication; DNA-Directed DNA Polymerase; DNA, Viral; Drug Resistance, Viral; Gene Expression Regulation, Viral; Guanosine; Hepadnaviridae Infections; Hepatitis B virus; Hepatitis B Virus, Duck; Hepatitis, Viral, Animal; Hepatocytes; Humans; Lamivudine; Liver Neoplasms; Mutation; Purine Nucleosides; Reverse Transcriptase Inhibitors; Thiophenes; Tumor Cells, Cultured	2002
Molecular mechanism of DApd/DXG against zidovudine- and lamivudine- drug resistant mutants: a molecular modelling approach. Antiviral chemistry & chemotherapy, 2002, Volume: 13, Issue:2 Topics: Anti-HIV Agents; Binding Sites; Dioxolanes; Drug Resistance; Guanosine; HIV-1; Lamivudine; Models, Molecular; Mutation, Missense; Protein Binding; Purine Nucleosides; Reverse Transcriptase Inhibitors; RNA-Directed DNA Polymerase; Structure-Activity Relationship; Zidovudine	2002
Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases. Biochemical pharmacology, 2004, Nov-01, Volume: 68, Issue:9 Topics: Antiviral Agents; Dioxolanes; Guanosine; Guanosine Triphosphate; Humans; Phosphorylation; Phosphotransferases; Purine Nucleosides; Tumor Cells, Cultured	2004
Synthesis and anti-HIV activity of (-)-beta-D-(2R,4R)-1,3-dioxolane-2,6-diamino purine (DAPD) (amdoxovir) and (-)-beta-D-(2R,4R)-1,3-dioxolane guanosine (DXG) prodrugs. Antiviral research, 2007, Volume: 75, Issue:3 Topics: Animals; Anti-HIV Agents; Cell Line; Dioxolanes; Drug Stability; Guanosine; HIV; HIV Infections; Humans; Leukocytes, Mononuclear; Prodrugs; Purine Nucleosides; Solubility	2007