amarogentin has been researched along with iridoids in 42 studies
| Studies (amarogentin) | Trials (amarogentin) | Recent Studies (post-2010) (amarogentin) | Studies (iridoids) | Trials (iridoids) | Recent Studies (post-2010) (iridoids) |
|---|---|---|---|---|---|
| 45 | 0 | 35 | 3,369 | 23 | 2,121 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (4.76) | 18.2507 |
| 2000's | 7 (16.67) | 29.6817 |
| 2010's | 24 (57.14) | 24.3611 |
| 2020's | 9 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Chakravarty, AK; Cordell, GA; Gil, RR; Majumder, HK; Mukhopadhyay, S; Ray, S | 1 |
| Basu, MK; Medda, S; Mukhopadhyay, S | 1 |
| Maier, UH; Wang, CZ; Zenk, MH | 1 |
| Guillaume, A; Härtle, B; Keil, M; Psiorz, M | 1 |
| Das, A; Das, S; Mandal, S; Saha, P | 1 |
| Asthana, RK; Gupta, RC; Suryawanshi, S | 2 |
| Citová, I; Ganzera, M; Solich, P; Stuppner, H | 1 |
| Appendino, G; Batram, C; Behrens, M; Brockhoff, A; Kuhn, C; Meyerhof, W | 1 |
| Barbosa, AC; Bhowmik, PC; Jha, PK; Phoboo, S; Pinto, Mda S; Sarkar, D; Shetty, K | 1 |
| Akileshwari, C; Joksić, G; Muthenna, P; Nastasijević, B; Petrash, JM; Reddy, GB | 1 |
| Das, A; Das, S; Mandal, S; Pal, D; Panda, CK; Roy, A; Sur, S | 1 |
| Bafna, K; Shukla, S; Sundar, D; Thorat, SS | 1 |
| Chiu, HC; Lee, TY; Lien, LM; Lin, KH; Lu, WJ; Sheu, JR; Thomas, PA; Yen, TL | 1 |
| Caprioli, G; Maggi, F; Marín, R; Mustafa, AM; Ricciutelli, M; Sagratini, G; Vittori, S | 1 |
| Elsholz, FA; Haarhaus, B; Kersten, A; Müller, WE; Schempp, CM; Wölfle, U | 1 |
| Chauhan, RS; Kumar, V; Sood, H | 1 |
| Chauhan, RS; Kumar, V; Padhan, JK; Singh, TR; Sood, H | 1 |
| Banerjee, K; Das, A; Mandal, S; Pal, D; Panda, CK; Roy, A; Sur, S | 1 |
| Li, QX; Li, YL; Liu, RJ; Shen, XQ | 1 |
| Behrens, M; Engel, A; Hübner, S; Kohl, S; Lossow, K; Meyerhof, W; Roudnitzky, N; Thalmann, S; Wooding, SP | 1 |
| Haarhaus, B; Schempp, CM; Wölfle, U | 1 |
| Khanal, S; Pant, DR; Shakya, N; Thapa, K | 1 |
| Akiyama, H; Amakura, Y; Ito, Y; Morimoto, S; Sugimoto, N; Tada, A; Yamazaki, T; Yoshida, T; Yoshimura, M | 1 |
| Nakamura, M; Rai, A; Saito, K; Suzuki, H; Takahashi, H; Yamazaki, M | 1 |
| Gong, J; Huang, C; Li, R; Zhang, Y | 1 |
| Chao, PC; Cheng, JT; Ku, PM; Lee, KS; Niu, CS; Niu, HS | 1 |
| Cao, W; Li, H; Wang, F; Wang, SW; Zhang, T; Zhang, Y; Zhao, H | 1 |
| He, Q; Li, H; Wang, F; Wang, S; Zhang, M; Zhang, T; Zhang, Y; Zhao, H | 1 |
| Kumar Panda, C; Mandal, S; Pal, D; Roy, R; Sur, S | 1 |
| Kumar, V; Patel, DK; Patel, K; Rahman, M; Verma, A | 1 |
| Morimoto, S; Morita, Y; Sakamoto, S; Tanaka, H; Wada, S; Yamaguchi, T | 1 |
| Chandel, S; Dixit, M; Gromiha, MM; Manoj, N; Mehta, N; Potunuru, UR; Priya, KV; Raman, T; Ramar, M; Varsha, MKNS | 1 |
| Dey, A; Gupta, RC; Kaur, P; Malik, T; Pandey, DK | 1 |
| Cheng, L; Disasa, D; Liu, Q; Manzoor, M; Qi, J; Wang, Y; Xiang, L | 1 |
| Juengwatanatrakul, T; Lohseethong, K; Morimoto, S; Nuntawong, P; Putalun, W; Sakamoto, S; Tanaka, H; Yusakul, G | 1 |
| Gu, H; Wang, J; Zhang, Y | 1 |
| Anandraj, A; Bhattacharyya, S; Govindasamy, V; Jaishee, N; Kar, P; Kinoshita, M; Kumar, V; Malhotra, H; Mukhopadhyay, S; Naidoo, D; Roy, A; Sen, A; Subramaniam, MD; Vellingiri, B | 1 |
| Bastianini, M; Cardellini, F; Epifano, F; Fiorito, S; Genovese, S; Marchetti, L; Mascioli, F; Palumbo, L; Spogli, R | 1 |
| Bhardwaj, C; Sharma, R; Sharma, YP; Thakur, P | 1 |
| Cao, H; Fan, W; Pan, J; Peng, A; Peng, J; Tan, Z; Wang, W; Zhou, Z | 1 |
| Song, B; Zhou, W | 1 |
1 review(s) available for amarogentin and iridoids
| Article | Year |
|---|---|
Amarogentin as Topical Anticancer and Anti-Infective Potential: Scope of Lipid Based Vesicular in its Effective Delivery.
Topics: Administration, Topical; Animals; Anti-Infective Agents; Antineoplastic Agents; Humans; Iridoids; Lipids; Patents as Topic; Plant Extracts; Plants, Medicinal; Swertia | 2019 |
41 other study(ies) available for amarogentin and iridoids
| Article | Year |
|---|---|
Amarogentin, a naturally occurring secoiridoid glycoside and a newly recognized inhibitor of topoisomerase I from Leishmania donovani.
Topics: Animals; DNA, Protozoan; Enzyme Inhibitors; Glucosides; India; Iridoids; Leishmania donovani; Magnetic Resonance Spectroscopy; Plants, Medicinal; Pyrans; Topoisomerase I Inhibitors | 1996 |
Evaluation of the in-vivo activity and toxicity of amarogentin, an antileishmanial agent, in both liposomal and niosomal forms.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Antiprotozoal Agents; Cricetinae; Drug Carriers; Glucosides; Iridoids; Leishmania donovani; Leishmaniasis, Visceral; Liposomes; Mesocricetus; Pyrans; Spleen; Surface-Active Agents; Treatment Outcome | 1999 |
Synthesis of 3,3',5-trihydroxybiphenyl-2-carboxylic acid, a component of the bitterest natural product amarogentin and its coenzyme A and N-acetyl cysteamine thiol esters.
Topics: Coenzyme A; Cysteamine; Esters; Glucosides; Iridoids; Molecular Structure; Pyrans; Spectrum Analysis | 2000 |
Production of amarogentin in root cultures of Swertia chirata.
Topics: Bioreactors; Chitin; Chitosan; Culture Media; Culture Techniques; Glucosides; Iridoids; Plant Roots; Plants, Medicinal; Pyrans; Rhizobium | 2000 |
Amarogentin can reduce hyperproliferation by downregulation of Cox-II and upregulation of apoptosis in mouse skin carcinogenesis model.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Apoptosis; Caspase 3; Cell Proliferation; Cyclooxygenase 2; Disease Models, Animal; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Glucosides; In Situ Nick-End Labeling; Iridoids; Male; Medicine, Traditional; Membrane Proteins; Mice; Phytotherapy; Plant Extracts; Skin Neoplasms; Swertia; Up-Regulation | 2006 |
Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation.
Topics: Animals; Chromatography, Liquid; Cinnamates; Glucosides; Iridoid Glucosides; Iridoids; Male; Plant Preparations; Pyrones; Rats; Rats, Sprague-Dawley; Reference Standards; Reproducibility of Results; Swertia; Tandem Mass Spectrometry; Xanthones | 2007 |
Determination of gentisin, isogentisin, and amarogentin in Gentiana lutea L. by capillary electrophoresis.
Topics: Calibration; Chromatography, High Pressure Liquid; Electrophoresis, Capillary; Gentiana; Glucosides; Iridoids; Molecular Structure; Xanthones | 2008 |
Assessment of systemic interaction between Swertia chirata extract and its Bioactive constituents in rabbits.
Topics: Animals; Drug Interactions; Glucosides; Iridoids; Male; Plant Extracts; Rabbits; Swertia; Tandem Mass Spectrometry; Xanthones | 2009 |
The human bitter taste receptor hTAS2R50 is activated by the two natural bitter terpenoids andrographolide and amarogentin.
Topics: Cell Line; Diterpenes; Gene Expression; Glucosides; Humans; Iridoids; Molecular Conformation; Receptors, G-Protein-Coupled | 2009 |
Phenolic-linked biochemical rationale for the anti-diabetic properties of Swertia chirayita (Roxb. ex Flem.) Karst.
Topics: Angiotensin-Converting Enzyme Inhibitors; Antioxidants; Biphenyl Compounds; Chromatography, High Pressure Liquid; Glycoside Hydrolase Inhibitors; Hypoglycemic Agents; Inhibitory Concentration 50; Iridoids; Nepal; Phenols; Picrates; Plant Extracts; Swertia; Xanthones | 2013 |
Inhibition of aldose reductase by Gentiana lutea extracts.
Topics: Aldehyde Reductase; Animals; Biological Assay; Erythrocytes; Gentiana; Glucose; Humans; Iridoid Glycosides; Iridoids; Male; Methanol; Plant Extracts; Rats; Sorbitol | 2012 |
Prevention of liver carcinogenesis by amarogentin through modulation of G1/S cell cycle check point and induction of apoptosis.
Topics: Animals; Apoptosis; Body Weight; Cell Cycle Checkpoints; Cell Proliferation; Chemoprevention; Female; G1 Phase; Iridoids; Liver; Liver Neoplasms, Experimental; Mice; Phosphorylation; Retinoblastoma Protein; S Phase | 2012 |
The bitter barricading of prostaglandin biosynthesis pathway: understanding the molecular mechanism of selective cyclooxygenase-2 inhibition by amarogentin, a secoiridoid glycoside from Swertia chirayita.
Topics: Amino Acid Motifs; Biosynthetic Pathways; Catalytic Domain; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Enzyme Stability; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Iridoids; Molecular Docking Simulation; Molecular Dynamics Simulation; Prostaglandins; Protein Binding; Structural Homology, Protein; Swertia; Thermodynamics | 2014 |
Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adenine; Adenosine Triphosphate; Animals; Arachidonic Acid; Collagen; Cyclic GMP; Guanylate Cyclase; Humans; Iridoids; MAP Kinase Signaling System; Mice; Oxadiazoles; Phospholipase C gamma; Plant Extracts; Platelet Activation; Protein Kinase C; Quinoxalines; Thrombin; Thromboembolism; Thrombosis | 2014 |
Comparative HPLC/ESI-MS and HPLC/DAD study of different populations of cultivated, wild and commercial Gentiana lutea L.
Topics: Alcoholic Beverages; Chromatography, High Pressure Liquid; Gentiana; Iridoid Glucosides; Iridoids; Mass Spectrometry; Plant Roots; Pyrones; Taste; Xanthones | 2015 |
Expression and functional activity of the bitter taste receptors TAS2R1 and TAS2R38 in human keratinocytes.
Topics: Adult; Animals; Cell Line; Cells, Cultured; Humans; Iridoids; Keratinocytes; Mice; NIH 3T3 Cells; Piperidines; Receptors, G-Protein-Coupled; Tongue | 2015 |
Detection of intermediates through high-resolution mass spectrometry for constructing biosynthetic pathways for major chemical constituents in a medicinally important herb, Swertia chirayita.
Topics: Biosynthetic Pathways; Glucosides; Hypoglycemic Agents; Iridoid Glucosides; Iridoids; Plants, Medicinal; Pyrans; Secondary Metabolism; Swertia; Tandem Mass Spectrometry; Xanthones | 2015 |
Contents of therapeutic metabolites in Swertia chirayita correlate with the expression profiles of multiple genes in corresponding biosynthesis pathways.
Topics: Iridoid Glucosides; Iridoids; Plant Roots; Plants, Medicinal; Pyrones; Swertia; Xanthones | 2015 |
Amarogentin regulates self renewal pathways to restrict liver carcinogenesis in experimental mouse model.
Topics: Animals; Carbon Tetrachloride; Cell Proliferation; Cell Survival; Female; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Hep G2 Cells; Humans; Hyaluronan Receptors; Iridoids; Liver Neoplasms; Mice; Neoplastic Stem Cells; Wnt Signaling Pathway | 2016 |
Chinese Medicine Amygdalin and β-Glucosidase Combined with Antibody Enzymatic Prodrug System As A Feasible Antitumor Therapy.
Topics: Amygdalin; Antibodies, Monoclonal; Antineoplastic Agents; beta-Glucosidase; Cell-Penetrating Peptides; Humans; Iridoids; Prodrugs | 2018 |
Receptor Polymorphism and Genomic Structure Interact to Shape Bitter Taste Perception.
Topics: Alleles; Animals; Genetic Association Studies; Genotype; Haplotypes; Humans; Iridoids; Phenylthiourea; Polymorphism, Single Nucleotide; Quassins; Quinine; Receptors, G-Protein-Coupled; Sesquiterpenes; Sesquiterpenes, Guaiane; Taste Buds; Taste Perception; White People | 2015 |
Amarogentin Displays Immunomodulatory Effects in Human Mast Cells and Keratinocytes.
Topics: Cells, Cultured; Histamine; Humans; Immunologic Factors; Interleukin-6; Interleukin-8; Iridoids; Keratinocytes; Mast Cells; Matrix Metalloproteinase 1; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha | 2015 |
Phytochemical investigation of crude methanol extracts of different species of Swertia from Nepal.
Topics: Antioxidants; Chromatography, Thin Layer; Flavonoids; Free Radical Scavengers; Humans; Iridoid Glucosides; Iridoids; Methanol; Nepal; Phytochemicals; Plant Extracts; Plants, Medicinal; Polyphenols; Pyrones; Species Specificity; Swertia; Xanthones | 2015 |
Chromatographic Evaluation and Characterization of Components of Gentian Root Extract Used as Food Additives.
Topics: Chromatography, High Pressure Liquid; Food Additives; Gentiana; Iridoid Glucosides; Iridoids; Molecular Structure; Plant Extracts; Plant Roots | 2016 |
High-throughput sequencing and de novo transcriptome assembly of Swertia japonica to identify genes involved in the biosynthesis of therapeutic metabolites.
Topics: Biosynthetic Pathways; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Ontology; Genes, Plant; Glucosyltransferases; High-Throughput Nucleotide Sequencing; Iridoid Glucosides; Iridoids; Metabolome; Microsatellite Repeats; Molecular Sequence Annotation; Phylogeny; Plant Roots; Pyrones; Swertia; Transcriptome; Up-Regulation | 2016 |
Amarogentin Induces Apoptosis of Liver Cancer Cells via Upregulation of p53 and Downregulation of Human Telomerase Reverse Transcriptase in Mice.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; Iridoids; Liver Neoplasms; Male; Mice; Signal Transduction; Telomerase; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2017 |
Amarogentin ameliorates diabetic disorders in animal models.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Dose-Response Relationship, Drug; Fructose; Glucose Tolerance Test; Glucose Transporter Type 4; Hypoglycemic Agents; Insulin; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Iridoids; Liver; Male; Muscle, Skeletal; Phosphoenolpyruvate Carboxykinase (GTP); Rats, Wistar; Streptozocin | 2016 |
Protective Effects of Amarogentin against Carbon Tetrachloride-Induced Liver Fibrosis in Mice.
Topics: Actins; Albumins; Animals; Antioxidants; Carbon Tetrachloride; Cell Line; Dose-Response Relationship, Drug; Down-Regulation; Gentiana; Glycosides; Humans; Hydroxyproline; Iridoids; Liver Cirrhosis; Malondialdehyde; Mice; Mice, Inbred C57BL; Nucleotides, Cyclic; Oxidative Stress; Phytotherapy; Plant Extracts; Plant Roots; Swertia; Tissue Distribution | 2017 |
Serum metabonomics study of the hepatoprotective effect of amarogentin on CCl
Topics: Animals; Biomarkers; Carbon Tetrachloride; Discriminant Analysis; Disease Models, Animal; Drugs, Chinese Herbal; Gas Chromatography-Mass Spectrometry; Humans; Iridoids; Liver; Liver Cirrhosis; Male; Medicine, Chinese Traditional; Metabolic Networks and Pathways; Metabolome; Metabolomics; Mice; Mice, Inbred C57BL; Principal Component Analysis; Protective Agents; Tandem Mass Spectrometry | 2018 |
Epigallocatechin gallate in combination with eugenol or amarogentin shows synergistic chemotherapeutic potential in cervical cancer cell line.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Catechin; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferase 1; Drug Synergism; Eugenol; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Iridoids; LIM Domain Proteins; Tea; Tumor Suppressor Proteins; Uterine Cervical Neoplasms | 2018 |
Magnetic particles-based enzyme immunoassay for rapid determination of secoiridoid glycoside, amarogentin.
Topics: Antibodies, Immobilized; Antibodies, Monoclonal; Immunoenzyme Techniques; Iridoids; Limit of Detection; Magnets; Time Factors | 2019 |
Amarogentin, a secoiridoid glycoside, activates AMP- activated protein kinase (AMPK) to exert beneficial vasculo-metabolic effects.
Topics: AMP-Activated Protein Kinases; Animals; Atherosclerosis; Calorimetry; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Activation; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Iridoids; Lipids; Male; Mice; Mice, Inbred C57BL; Molecular Docking Simulation; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2019 |
Optimization of salicylic acid and chitosan treatment for bitter secoiridoid and xanthone glycosides production in shoot cultures of Swertia paniculata using response surface methodology and artificial neural network.
Topics: Chitosan; Glycosides; Iridoid Glucosides; Iridoids; Neural Networks, Computer; Pyrones; Salicylic Acid; Swertia; Xanthones | 2020 |
Amarogentin from
Topics: Aging; Antioxidants; Gentiana; Humans; Iridoids; Oxidative Stress | 2020 |
Competitive immunochromatographic test strips for the rapid semi-quantitative analysis of the biologically active bitter glycoside, amarogentin.
Topics: Antibodies, Monoclonal; Chromatography, Affinity; Enzyme-Linked Immunosorbent Assay; Gentianaceae; Gold; Iridoids; Metal Nanoparticles; Molecular Conformation; Reagent Strips | 2021 |
Amarogentin Inhibits Liver Cancer Cell Angiogenesis after Insufficient Radiofrequency Ablation via Affecting Stemness and the p53-Dependent VEGFA/Dll4/Notch1 Pathway.
Topics: AC133 Antigen; Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents, Phytogenic; Calcium-Binding Proteins; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Hepatectomy; Human Umbilical Vein Endothelial Cells; Humans; Iridoids; Liver Neoplasms; Male; Mice; Neoplastic Stem Cells; Neovascularization, Pathologic; Platelet Endothelial Cell Adhesion Molecule-1; Radiofrequency Ablation; Receptor, Notch1; Signal Transduction; Tumor Burden; Tumor Suppressor Protein p53; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2020 |
Anisotine and amarogentin as promising inhibitory candidates against SARS-CoV-2 proteins: a computational investigation.
Topics: Antiviral Agents; Coronavirus 3C Proteases; Coronavirus RNA-Dependent RNA Polymerase; COVID-19 Drug Treatment; Humans; Iridoids; Molecular Docking Simulation; Molecular Dynamics Simulation; Protease Inhibitors; SARS-CoV-2; Spike Glycoprotein, Coronavirus | 2022 |
An improved method for the isolation of amarogentin, the bitter principle of yellow gentian roots.
Topics: Gentiana; Humans; Iridoids; Plant Roots; Taste | 2021 |
A New RP-HPLC Method for Simultaneous Determination of Amaroswerin, Amarogentin and Andrographolide in a Herbal Drug "Chirayata".
Topics: Chromatography, High Pressure Liquid; Iridoids | 2023 |
Impact of Amarogentin on Gastric Carcinoma Cell Multiplication, Apoptosis and Migration via circKIF4A/miR-152-3p.
Topics: Apoptosis; bcl-2-Associated X Protein; Carcinoma; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Humans; Iridoids; MicroRNAs; Proto-Oncogene Proteins c-bcl-2; Stomach Neoplasms | 2022 |
Amarogentin has protective effects against sepsis-induced brain injury via modulating the AMPK/SIRT1/NF-κB pathway.
Topics: AMP-Activated Protein Kinases; Animals; Brain Injuries; DNA Nucleotidylexotransferase; Eosine Yellowish-(YS); Hematoxylin; Inflammation; Iridoid Glycosides; Iridoids; Lipopolysaccharides; Mice; NF-kappa B; Sepsis; Signal Transduction; Sirtuin 1 | 2022 |