amantadine and quinine

amantadine has been researched along with quinine in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (35.00)18.2507
2000's5 (25.00)29.6817
2010's8 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giacomini, KM; Schaner, ME; Zhang, L1
Topliss, JG; Yoshida, F1
Goralski, KB; Gorboulev, V; Koepsell, H; Lou, G; Prowse, MT; Sitar, DS; Volk, C1
Lombardo, F; Obach, RS; Waters, NJ1
Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L1
Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H1
Balzarini, J; Bharatam, PV; Chibale, K; Kaur, H; Little, S; Singh, K1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Sitar, DS; Smyth, DD; Wong, LT2
Escobar, MR; Sitar, DS; Smyth, DD; Wong, LT1
Aoki, FY; Gaudry, SE; McKenzie, JK; Sitar, DS; Smyth, DD1
Evans, SG; Havlik, I1
Gerzanich, V; Kuryatov, A; Lindstrom, J; Nelson, M; Olale, F1
Baker, ES; Lehane, AM; Martin, RE; Nash, MN; Richards, SN; Shafik, SH; Webster, MW1

Reviews

2 review(s) available for amantadine and quinine

ArticleYear
Membrane transporters in drug development.
    Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3

    Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs

2010
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

1 trial(s) available for amantadine and quinine

ArticleYear
Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine.
    Clinical pharmacology and therapeutics, 1993, Volume: 54, Issue:1

    Topics: Adult; Aged; Aging; Amantadine; Analysis of Variance; Drug Interactions; Female; Humans; Kidney; Male; Middle Aged; Quinidine; Quinine; Reference Values; Sex Characteristics

1993

Other Studies

17 other study(ies) available for amantadine and quinine

ArticleYear
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
    The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1

    Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection

1998
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 303, Issue:3

    Topics: Amantadine; Animals; Bicarbonates; Cell Line; Female; Humans; Kidney Tubules, Proximal; Male; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Rats, Sprague-Dawley; Xenopus laevis

2002
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
    Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
    Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:3

    Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution

2011
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
    European journal of medicinal chemistry, 2012, Volume: 52

    Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; DNA; Dogs; Heme; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Protoporphyrins; Pyrimidines; Structure-Activity Relationship; Viruses

2012
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Stereoselective inhibition of renal organic cation transport in human kidney.
    British journal of clinical pharmacology, 1992, Volume: 34, Issue:5

    Topics: Adult; Aged; Amantadine; Animals; Cations; Female; Humans; In Vitro Techniques; Kidney; Kidney Cortex; Male; Middle Aged; Quinidine; Quinine; Rats; Stereoisomerism

1992
Stereoselective inhibition of amantadine accumulation by quinine and quinidine in rat renal proximal tubules and cortical slices.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:1

    Topics: Amantadine; Animals; Biological Transport; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Proximal; Quinidine; Quinine; Rats; Stereoisomerism

1990
Gender-associated differences in rat renal tubular amantadine transport and absence of stereoselective transport inhibition by quinine and quinidine in distal tubules.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 267, Issue:3

    Topics: Amantadine; Animals; Biological Transport; Female; Kidney Tubules, Distal; Kidney Tubules, Proximal; Male; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stereoisomerism

1993
Effect of pH on in vitro potency of amantadine against Plasmodium falciparum.
    The American journal of tropical medicine and hygiene, 1996, Volume: 54, Issue:3

    Topics: Adamantane; Amantadine; Ammonium Chloride; Animals; Antimalarials; Chloroquine; Culture Media; Dose-Response Relationship, Drug; Drug Resistance; Humans; Hydrogen-Ion Concentration; Mefloquine; Plasmodium falciparum; Quinine

1996
Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 1997, Dec-01, Volume: 17, Issue:23

    Topics: Acetylcholine; Amantadine; Animals; Calcium; Calcium Channels; Cell Membrane Permeability; Circadian Rhythm; Dihydro-beta-Erythroidine; DNA, Complementary; Electric Conductivity; Epilepsies, Partial; Frontal Lobe; Genes, Dominant; Humans; Ion Channel Gating; Microinjections; Oocytes; Point Mutation; Quinine; Receptors, Nicotinic; Recombinant Fusion Proteins; Structure-Activity Relationship; Xenopus laevis

1997
Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.
    PLoS pathogens, 2016, Volume: 12, Issue:7

    Topics: Amantadine; Animals; Antimalarials; Biological Transport; Blotting, Western; Chloroquine; Drug Resistance; Fluorescent Antibody Technique; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Isoforms; Protozoan Proteins; Quinine; Xenopus laevis

2016