amantadine has been researched along with quinine in 20 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (35.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 8 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giacomini, KM; Schaner, ME; Zhang, L | 1 |
| Topliss, JG; Yoshida, F | 1 |
| Goralski, KB; Gorboulev, V; Koepsell, H; Lou, G; Prowse, MT; Sitar, DS; Volk, C | 1 |
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Artursson, P; Bergström, CA; Hoogstraate, J; Matsson, P; Norinder, U; Pedersen, JM | 1 |
| Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV | 1 |
| Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV | 1 |
| Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L | 1 |
| Ahlin, G; Bergström, F; Bredberg, U; Fridén, M; Hammarlund-Udenaes, M; Rehngren, M; Wan, H | 1 |
| Balzarini, J; Bharatam, PV; Chibale, K; Kaur, H; Little, S; Singh, K | 1 |
| Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR | 1 |
| Bellman, K; Knegtel, RM; Settimo, L | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Sitar, DS; Smyth, DD; Wong, LT | 2 |
| Escobar, MR; Sitar, DS; Smyth, DD; Wong, LT | 1 |
| Aoki, FY; Gaudry, SE; McKenzie, JK; Sitar, DS; Smyth, DD | 1 |
| Evans, SG; Havlik, I | 1 |
| Gerzanich, V; Kuryatov, A; Lindstrom, J; Nelson, M; Olale, F | 1 |
| Baker, ES; Lehane, AM; Martin, RE; Nash, MN; Richards, SN; Shafik, SH; Webster, MW | 1 |
2 review(s) available for amantadine and quinine
| Article | Year |
|---|---|
Membrane transporters in drug development.
Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs | 2010 |
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
1 trial(s) available for amantadine and quinine
| Article | Year |
|---|---|
Gender and age as factors in the inhibition of renal clearance of amantadine by quinine and quinidine.
Topics: Adult; Aged; Aging; Amantadine; Analysis of Variance; Drug Interactions; Female; Humans; Kidney; Male; Middle Aged; Quinidine; Quinine; Reference Values; Sex Characteristics | 1993 |
17 other study(ies) available for amantadine and quinine
| Article | Year |
|---|---|
Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa).
Topics: Carrier Proteins; Corticosterone; HeLa Cells; Humans; Membrane Proteins; Midazolam; Organic Cation Transporter 1; Permeability; Recombinant Proteins; Structure-Activity Relationship; Tetraethylammonium Compounds; Transfection | 1998 |
QSAR model for drug human oral bioavailability.
Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship | 2000 |
The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.
Topics: Amantadine; Animals; Bicarbonates; Cell Line; Female; Humans; Kidney Tubules, Proximal; Male; Organic Cation Transport Proteins; Organic Cation Transporter 1; Organic Cation Transporter 2; Rats; Rats, Sprague-Dawley; Xenopus laevis | 2002 |
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2).
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antipsychotic Agents; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Cell Line; Computer Simulation; Cytochrome P-450 Enzyme System; Drug-Related Side Effects and Adverse Reactions; Estradiol; Humans; Insecta; Liver; Models, Molecular; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Neoplasm Proteins; Pharmaceutical Preparations; Pharmacology; Structure-Activity Relationship | 2008 |
Physicochemical determinants of human renal clearance.
Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight | 2009 |
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations | 2010 |
Measurement of unbound drug exposure in brain: modeling of pH partitioning explains diverging results between the brain slice and brain homogenate methods.
Topics: Animals; Biological Transport; Brain; Chemical Phenomena; Dialysis; Hydrogen-Ion Concentration; In Vitro Techniques; Lysosomes; Male; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Tissue Distribution | 2011 |
2-Aminopyrimidine based 4-aminoquinoline anti-plasmodial agents. Synthesis, biological activity, structure-activity relationship and mode of action studies.
Topics: Aminoquinolines; Animals; Antimalarials; Cell Line; DNA; Dogs; Heme; Humans; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Plasmodium falciparum; Protoporphyrins; Pyrimidines; Structure-Activity Relationship; Viruses | 2012 |
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection | 2012 |
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation | 2014 |
Stereoselective inhibition of renal organic cation transport in human kidney.
Topics: Adult; Aged; Amantadine; Animals; Cations; Female; Humans; In Vitro Techniques; Kidney; Kidney Cortex; Male; Middle Aged; Quinidine; Quinine; Rats; Stereoisomerism | 1992 |
Stereoselective inhibition of amantadine accumulation by quinine and quinidine in rat renal proximal tubules and cortical slices.
Topics: Amantadine; Animals; Biological Transport; In Vitro Techniques; Kidney Cortex; Kidney Tubules, Proximal; Quinidine; Quinine; Rats; Stereoisomerism | 1990 |
Gender-associated differences in rat renal tubular amantadine transport and absence of stereoselective transport inhibition by quinine and quinidine in distal tubules.
Topics: Amantadine; Animals; Biological Transport; Female; Kidney Tubules, Distal; Kidney Tubules, Proximal; Male; Quinidine; Quinine; Rats; Rats, Sprague-Dawley; Sex Characteristics; Stereoisomerism | 1993 |
Effect of pH on in vitro potency of amantadine against Plasmodium falciparum.
Topics: Adamantane; Amantadine; Ammonium Chloride; Animals; Antimalarials; Chloroquine; Culture Media; Dose-Response Relationship, Drug; Drug Resistance; Humans; Hydrogen-Ion Concentration; Mefloquine; Plasmodium falciparum; Quinine | 1996 |
Mutation causing autosomal dominant nocturnal frontal lobe epilepsy alters Ca2+ permeability, conductance, and gating of human alpha4beta2 nicotinic acetylcholine receptors.
Topics: Acetylcholine; Amantadine; Animals; Calcium; Calcium Channels; Cell Membrane Permeability; Circadian Rhythm; Dihydro-beta-Erythroidine; DNA, Complementary; Electric Conductivity; Epilepsies, Partial; Frontal Lobe; Genes, Dominant; Humans; Ion Channel Gating; Microinjections; Oocytes; Point Mutation; Quinine; Receptors, Nicotinic; Recombinant Fusion Proteins; Structure-Activity Relationship; Xenopus laevis | 1997 |
Molecular Mechanisms for Drug Hypersensitivity Induced by the Malaria Parasite's Chloroquine Resistance Transporter.
Topics: Amantadine; Animals; Antimalarials; Biological Transport; Blotting, Western; Chloroquine; Drug Resistance; Fluorescent Antibody Technique; Humans; Malaria, Falciparum; Membrane Transport Proteins; Mutagenesis, Site-Directed; Plasmodium falciparum; Protein Isoforms; Protozoan Proteins; Quinine; Xenopus laevis | 2016 |