amantadine and methyldopa

amantadine has been researched along with methyldopa in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19906 (35.29)18.7374
1990's0 (0.00)18.2507
2000's5 (29.41)29.6817
2010's6 (35.29)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Lombardo, F; Obach, RS; Waters, NJ1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Choi, SS; Contrera, JF; Hastings, KL; Kruhlak, NL; Sancilio, LF; Weaver, JL; Willard, JM1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV1
Glen, RC; Lowe, R; Mitchell, JB1
Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V1
Bellman, K; Knegtel, RM; Settimo, L1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Cohen, MR1
Marsden, CD; Mindham, RH; Parkes, JD1
Feigenson, JS; McDowell, FH; Sweet, RD1
Calne, DB; Reid, JL1
Duvoisin, RC; Yahr, MD1
Calne, DB; Hilson, A; Rao, SK; Vakil, SD1

Reviews

4 review(s) available for amantadine and methyldopa

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Antiparkinsonian drugs: pharmacological and therapeutic aspects.
    Drugs, 1972, Volume: 4, Issue:1

    Topics: Acetylcholine; Adrenergic beta-Antagonists; Amantadine; Amphetamine; Antiparkinson Agents; Apomorphine; Basal Ganglia Diseases; Carboxy-Lyases; Dihydroxyphenylalanine; Dopamine; Histamine H1 Antagonists; Humans; Mental Disorders; Methyldopa; Movement Disorders; Norepinephrine; Parasympatholytics; Serotonin; Synaptic Transmission

1972
Drug therapy of parkinsonism.
    The New England journal of medicine, 1972, Jul-06, Volume: 287, Issue:1

    Topics: Amantadine; Amitriptyline; Amphetamine; Antiparkinson Agents; Dihydroxyphenylalanine; Drug Antagonism; Drug Synergism; Humans; Imipramine; Methyldopa; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease; Phenothiazines

1972
Augmenting the action of levodopa.
    Postgraduate medical journal, 1972, Volume: 48, Issue:565

    Topics: Amantadine; Antacids; Apomorphine; Carboxy-Lyases; Catechol O-Methyltransferase Inhibitors; Dihydroxyphenylalanine; Dopamine beta-Hydroxylase; Drug Synergism; Humans; Methyldopa; Monoamine Oxidase Inhibitors; Parasympatholytics; Parkinson Disease

1972

Trials

1 trial(s) available for amantadine and methyldopa

ArticleYear
Psychiatric symptoms during l-dopa therapy for Parkinson's disease and their relationship to physical disability.
    Psychological medicine, 1976, Volume: 6, Issue:1

    Topics: Aged; Amantadine; Carbidopa; Clinical Trials as Topic; Depression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Interview, Psychological; Levodopa; Male; Mental Status Schedule; Methyldopa; Middle Aged; Parkinson Disease; Placebos; Recurrence; Trihexyphenidyl

1976

Other Studies

12 other study(ies) available for amantadine and methyldopa

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Development of a phospholipidosis database and predictive quantitative structure-activity relationship (QSAR) models.
    Toxicology mechanisms and methods, 2008, Volume: 18, Issue:2-3

    Topics:

2008
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations

2010
Predicting phospholipidosis using machine learning.
    Molecular pharmaceutics, 2010, Oct-04, Volume: 7, Issue:5

    Topics: Animals; Artificial Intelligence; Databases, Factual; Drug Discovery; Humans; Lipidoses; Models, Biological; Phospholipids; Support Vector Machine

2010
FDA-approved drug labeling for the study of drug-induced liver injury.
    Drug discovery today, 2011, Volume: 16, Issue:15-16

    Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Design; Drug Labeling; Drug-Related Side Effects and Adverse Reactions; Humans; Pharmaceutical Preparations; Reproducibility of Results; United States; United States Food and Drug Administration

2011
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds.
    Pharmaceutical research, 2014, Volume: 31, Issue:4

    Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation

2014
Amantadine and alpha-methyldopa: effects and interactions.
    The American journal of psychiatry, 1979, Volume: 136, Issue:6

    Topics: Amantadine; Drug Therapy, Combination; Humans; Methyldopa; Psychoses, Substance-Induced

1979
Piribedil: its synergistic effect in multidrug regimens for parkinsonism.
    Neurology, 1976, Volume: 26, Issue:5

    Topics: Aged; Amantadine; Drug Synergism; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Methyldopa; Middle Aged; Movement Disorders; Parasympatholytics; Parkinson Disease; Piperazines; Piribedil

1976