amantadine and cocaine

amantadine has been researched along with cocaine in 42 studies

Research

Studies (42)

Timeframe	Studies, this research(%)	All Research%
pre-1990	18 (42.86)	18.7374
1990's	14 (33.33)	18.2507
2000's	8 (19.05)	29.6817
2010's	2 (4.76)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gao, F; Lombardo, F; Obach, RS; Shalaeva, MY	1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Bellman, K; Knegtel, RM; Settimo, L	1
Badia, A; Garcia-Sevilla, JA; Laporte, J	1
Brown, BS; Haertzen, CC; Jaffe, JH; Kolar, AF; Michaelson, BS; Weddington, WW	1
Alterman, AI; Antelo, RE; Cornish, JW; Droba, M; O'Brien, CP; Parikh, GA; Sweeney, KK	1
Falcione, J; Kosten, TR; Morgan, CM; Schottenfeld, RS	1
Kosten, TR; Ziedonis, DM	1
Brown, BS; Haertzen, CA; Hess, JM; Jaffe, JH; Kolar, AF; Mahaffey, JR; Weddington, WW	1
Kosten, TR; Morgan, CH; Schottenfeld, RS	1
Brown, BS; Haertzen, CA; Hess, JM; Weddington, WW	1
Gold, MS; Taylor, WA	1
Gawin, FH; Kleber, HD; Kosten, TR; Morgan, C	1
Feather, JN; Folts, DJ; Giannini, AJ; Sullivan, BS	1
Brown, BS; Haertzen, CA; Hess, JM; Kolar, AF; Mahaffey, JR; Weddington, WW	1
Shannon, J; Tennant, F	1
Dougan, DF; Duffield, P; Wade, DN	1
Pike, RF	1
Gawin, F; Kleber, H; Kosten, T; Morgan, C	1
Griffiths, RR; Sannerud, CA	1
Chordia, PL; Escovar, IL; Handelsman, L; Lowinson, JH; Marion, IJ	1
Berman, ML; Tennant, F	1
Sagherian, AA; Tennant, FS	1
Wesemann, W; Zilliken, F	1
Baran, L; Maj, J; Sowińska, H	1
Kubo, T; Takagi, H	1
Baldessarini, RJ; Vogt, M	1
Bönisch, H; Rodrigues-Pereira, E	1
Westermann, KH	1
Kosten, T; Leal, J; Ziedonis, D	1
Ellinwood, EH; Joyner, C; King, GR	1
Browning, RG; Merigian, KS	1
Handelsman, L; Limpitlaw, L; Paris, P; Schmeidler, J; Stimmel, B; Williams, D	1
Hashimoto, K; Minabe, Y; Narita, N; Tamura, A; Tomitaka, S	1
Alterman, A; Cornish, J; Epperson, L; Kampman, K; O'Brien, CP; Sparkman, T; Volpicelli, JR; Weinrieb, R	1
Budziszewska, B; Jaworska-Feil, L; Kajta, M; Lasoń, W	1
Alterman, AI; Cornish, J; Kampman, KM; O'Brien, CP; Volpicelli, JR	1
Collins, ED; Foltin, RW; Haney, M; Hart, CL; Vosburg, SK	1
Atzram, M; Dackis, C; Gariti, P; Kampman, KM; Lynch, KG; O'Brien, CP; Pettinati, H; Sparkman, T; Tirado, C	1

Reviews

1 review(s) available for amantadine and cocaine

Article	Year
Pharmacologic approaches to the treatment of cocaine dependence. The Western journal of medicine, 1990, Volume: 152, Issue:5 Topics: Amantadine; Antidepressive Agents, Tricyclic; Bromocriptine; Cocaine; Dopamine Agents; Humans; Substance-Related Disorders	1990

Trials

18 trial(s) available for amantadine and cocaine

Article	Year
Treatment of cocaine dependence in methadone maintenance clients: a pilot study comparing the efficacy of desipramine and amantadine. The International journal of the addictions, 1992, Volume: 27, Issue:7 Topics: Adolescent; Adult; Amantadine; Baltimore; Cocaine; Desipramine; Female; Follow-Up Studies; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Pilot Projects; Placebos; Research Design; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders; United States	1992
Amantadine may facilitate detoxification of cocaine addicts. Drug and alcohol dependence, 1992, Volume: 31, Issue:1 Topics: Adult; Amantadine; Cocaine; Day Care, Medical; Double-Blind Method; Follow-Up Studies; Humans; Male; Middle Aged; Neurologic Examination; Substance Abuse Detection; Substance Abuse Treatment Centers; Substance Withdrawal Syndrome; Substance-Related Disorders	1992
Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine. Archives of general psychiatry, 1992, Volume: 49, Issue:11 Topics: Adult; Amantadine; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Methadone; Opioid-Related Disorders; Placebos; Substance Abuse Detection; Substance-Related Disorders; Treatment Outcome	1992
Depression as a prognostic factor for pharmacological treatment of cocaine dependence. Psychopharmacology bulletin, 1991, Volume: 27, Issue:3 Topics: Adult; Amantadine; Cocaine; Depression; Desipramine; Female; Humans; Male; Prognosis; Psychiatric Status Rating Scales; Substance-Related Disorders	1991
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. The American journal of drug and alcohol abuse, 1991, Volume: 17, Issue:2 Topics: Adult; Amantadine; Cocaine; Combined Modality Therapy; Desipramine; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Male; Psychotherapy; Single-Blind Method; Substance-Related Disorders	1991
Amantadine and desipramine in the treatment of cocaine abusing methadone maintained patients. NIDA research monograph, 1990, Volume: 105 Topics: Adult; Amantadine; Cocaine; Desipramine; Double-Blind Method; Female; Humans; Male; Methadone; Opioid-Related Disorders; Substance-Related Disorders	1990
Psychological reactions and retention by cocaine addicts during treatment according to HIV-serostatus: a matched-control study. The American journal of drug and alcohol abuse, 1991, Volume: 17, Issue:3 Topics: Adaptation, Psychological; Adult; Affect; AIDS Serodiagnosis; Amantadine; Baltimore; Cocaine; Combined Modality Therapy; Desipramine; Female; Fluoxetine; HIV Seropositivity; Humans; Male; Patient Dropouts; Psychotherapy; Sick Role; Substance-Related Disorders	1991
Double-blind evaluation of the effect of acute amantadine on cocaine craving. Psychopharmacology, 1989, Volume: 97, Issue:3 Topics: Amantadine; Cocaine; Double-Blind Method; Humans; Substance-Related Disorders	1989
Bromocriptine and amantadine in cocaine detoxification. Psychiatry research, 1989, Volume: 29, Issue:1 Topics: Adult; Amantadine; Brain; Bromocriptine; Clinical Trials as Topic; Cocaine; Humans; Male; Random Allocation; Receptors, Dopamine; Substance Withdrawal Syndrome; Substance-Related Disorders	1989
Comparison of amantadine and desipramine combined with psychotherapy for treatment of cocaine dependence. NIDA research monograph, 1989, Volume: 95 Topics: Amantadine; Clinical Trials as Topic; Cocaine; Combined Modality Therapy; Desipramine; Follow-Up Studies; Humans; Personality Tests; Psychotherapy; Single-Blind Method; Substance-Related Disorders	1989
A pilot trial of amantadine for ambulatory withdrawal for cocaine dependence. NIDA research monograph, 1988, Volume: 81 Topics: Adult; Amantadine; Bromocriptine; Clinical Trials as Topic; Cocaine; Double-Blind Method; Humans; Patient Compliance; Substance Withdrawal Syndrome	1988
Double-blind comparison of amantadine and bromocriptine for ambulatory withdrawal from cocaine dependence. Archives of internal medicine, 1987, Volume: 147, Issue:1 Topics: Adolescent; Adult; Amantadine; Ambulatory Care; Bromocriptine; Clinical Trials as Topic; Cocaine; Double-Blind Method; Humans; Patient Compliance; Substance Withdrawal Syndrome	1987
Antisocial personality disorder as a prognostic factor for pharmacotherapy of cocaine dependence. Drug and alcohol dependence, 1994, Volume: 35, Issue:1 Topics: Adult; Amantadine; Antisocial Personality Disorder; Cocaine; Combined Modality Therapy; Comorbidity; Depressive Disorder; Desipramine; Double-Blind Method; Female; Follow-Up Studies; Heroin Dependence; Humans; Male; Methadone; Patient Dropouts; Substance Abuse Detection; Substance-Related Disorders	1994
Amantadine does not reduce cocaine use or craving in cocaine-dependent methadone maintenance patients. Drug and alcohol dependence, 1995, Volume: 39, Issue:3 Topics: Adult; Amantadine; Cocaine; Dopamine Agonists; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders	1995
Amantadine in the early treatment of cocaine dependence: a double-blind, placebo-controlled trial. Drug and alcohol dependence, 1996, Volume: 41, Issue:1 Topics: Adult; Alcoholism; Amantadine; Cocaine; Comorbidity; Dopamine Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Male; Opioid-Related Disorders; Substance Abuse Detection; Treatment Outcome	1996
Amantadine in the treatment of cocaine-dependent patients with severe withdrawal symptoms. The American journal of psychiatry, 2000, Volume: 157, Issue:12 Topics: Amantadine; Ambulatory Care; Cocaine; Cocaine-Related Disorders; Dopamine Agents; Double-Blind Method; Female; Humans; Male; Placebos; Severity of Illness Index; Substance Abuse Detection; Substance Withdrawal Syndrome; Treatment Outcome	2000
Amantadine does not modulate reinforcing, subjective, or cardiovascular effects of cocaine in humans. Pharmacology, biochemistry, and behavior, 2003, Volume: 76, Issue:3-4 Topics: Adult; Amantadine; Cocaine; Cocaine-Related Disorders; Crack Cocaine; Dopamine Agents; Dose-Response Relationship, Drug; Female; Hemodynamics; Humans; Male; Middle Aged; Reinforcement, Psychology; Surveys and Questionnaires	2003
A double-blind, placebo-controlled trial of amantadine, propranolol, and their combination for the treatment of cocaine dependence in patients with severe cocaine withdrawal symptoms. Drug and alcohol dependence, 2006, Nov-08, Volume: 85, Issue:2 Topics: Adrenergic beta-Antagonists; Adult; Amantadine; Analgesics, Non-Narcotic; Cocaine; Cocaine-Related Disorders; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Male; Neurologic Examination; Patient Dropouts; Propranolol; Substance Abuse Detection; Substance Withdrawal Syndrome	2006

Other Studies

23 other study(ies) available for amantadine and cocaine

Article	Year
Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics. Journal of medicinal chemistry, 2004, Feb-26, Volume: 47, Issue:5 Topics: Algorithms; Blood Proteins; Half-Life; Humans; Hydrogen-Ion Concentration; Models, Biological; Pharmaceutical Preparations; Pharmacokinetics; Protein Binding; Statistics as Topic; Tissue Distribution	2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model. Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2 Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase	2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Comparison of the accuracy of experimental and predicted pKa values of basic and acidic compounds. Pharmaceutical research, 2014, Volume: 31, Issue:4 Topics: Chemistry, Pharmaceutical; Forecasting; Hydrogen-Ion Concentration; Pharmaceutical Preparations; Random Allocation	2014
Nature of neuronal uptake and noradrenaline--adrenaline effects in the isolated rat vas deferens. European journal of pharmacology, 1975, Volume: 31, Issue:2 Topics: Amantadine; Animals; Cocaine; Computers; Depression, Chemical; Desipramine; Epinephrine; Guanethidine; In Vitro Techniques; Male; Neurons; Norepinephrine; Rats; Vas Deferens	1975
Quantitative urine testing. A new tool for diagnosing and treating cocaine use. Postgraduate medicine, 1989, Sep-01, Volume: 86, Issue:3 Topics: Adolescent; Adult; Amantadine; Amino Acids; Cocaine; Female; Humans; Levodopa; Male; Radioimmunoassay; Substance-Related Disorders	1989
Modulation of dopamine receptors in the Tapes clam by dextroamphetamine and phenylethanolamine. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1987, Volume: 86, Issue:2 Topics: Adenosine Monophosphate; Amantadine; Animals; Benztropine; Bivalvia; Chlorphenamidine; Clozapine; Cocaine; Dextroamphetamine; Dopamine; Ethanolamines; Heart Rate; Myocardial Contraction; Receptors, Dopamine; Serotonin; Tetrahydronaphthalenes	1987
Cocaine withdrawal. An effective three-drug regimen. Postgraduate medicine, 1989, Volume: 85, Issue:4 Topics: Amantadine; Cocaine; Humans; Lorazepam; Substance Withdrawal Syndrome; Substance-Related Disorders; Tryptophan	1989
Amantadine: evaluation of reinforcing properties and effect on cocaine self-injection in baboons. Drug and alcohol dependence, 1988, Volume: 21, Issue:3 Topics: Amantadine; Animals; Cocaine; Dose-Response Relationship, Drug; Male; Papio; Reinforcement, Psychology; Self Administration	1988
Amantadine for treatment of cocaine dependence in methadone-maintained patients. The American journal of psychiatry, 1988, Volume: 145, Issue:4 Topics: Adult; Amantadine; Cocaine; Female; Humans; Male; Methadone; Middle Aged; Opioid-Related Disorders; Substance-Related Disorders	1988
Stepwise detoxification from cocaine. A promising regimen. Postgraduate medicine, 1988, Volume: 84, Issue:2 Topics: Adolescent; Adult; Amantadine; Bromocriptine; Cocaine; Desipramine; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Substance Withdrawal Syndrome; Substance-Related Disorders; Tryptophan; Tyrosine	1988
Adamantanamines and their derivatives as sensitizing agents for 5-hydroxytryptamine-induced contraction of smooth muscle. The Journal of pharmacy and pharmacology, 1967, Volume: 19, Issue:3 Topics: Amantadine; Animals; Cocaine; Dibenzylchlorethamine; Imipramine; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuraminidase; Propylamines; Rats; Sensory Receptor Cells; Serotonin	1967
The effect of amantadine on motor activity and catalepsy in rats. Psychopharmacologia, 1972, Volume: 24, Issue:2 Topics: Amantadine; Animals; Brain; Catalepsy; Catecholamines; Chlorpromazine; Cocaine; Desipramine; Dihydroxyphenylalanine; Drug Synergism; Female; Humans; Male; Methyltyrosines; Motor Activity; Nialamide; Rats; Rats, Inbred Strains; Reserpine; Spiro Compounds; Thiocarbamates	1972
A possible mechanism of arrhythmia induced by 1-adamantanamine. Japanese journal of pharmacology, 1967, Volume: 17, Issue:4 Topics: Amantadine; Animals; Arrhythmias, Cardiac; Catecholamines; Cocaine; Electrocardiography; Female; Guinea Pigs; Heart Atria; In Vitro Techniques; Male; Norepinephrine; Propranolol; Rabbits; Reserpine; Ventricular Fibrillation	1967
Uptake and release of norepinephrine by rat brain tissue fractions prepared by ultrafiltration. Journal of neurochemistry, 1971, Volume: 18, Issue:6 Topics: Amantadine; Animals; Brain; Catecholamines; Cocaine; Cytoplasmic Granules; Dialysis; Filtration; Imipramine; Monoamine Oxidase; Nerve Endings; Norepinephrine; Ouabain; Phenethylamines; Potassium; Rats; Serotonin; Synapses; Synaptic Vesicles; Tritium	1971
Uptake of 14C-tyramine and release of extravesicular 3H-noradrenaline in isolated perfused rabbit hearts. Naunyn-Schmiedeberg's archives of pharmacology, 1983, Volume: 323, Issue:3 Topics: Amantadine; Amphetamine; Animals; Cocaine; Corticosterone; Female; In Vitro Techniques; Kinetics; Male; Myocardium; Norepinephrine; Rabbits; Sodium; Tyramine	1983
Supersensitivity following repeated administration of dopaminergic agonists. Acta physiologica et pharmacologica Bulgarica, 1982, Volume: 8, Issue:1-2 Topics: Amantadine; Amphetamine; Animals; Apomorphine; Cocaine; Dopamine; Exploratory Behavior; Female; Humans; Motor Activity; Rats; Rats, Inbred Strains; Stereotyped Behavior	1982
Continuous or intermittent cocaine administration: effects of amantadine treatment during withdrawal. Pharmacology, biochemistry, and behavior, 1994, Volume: 47, Issue:3 Topics: Amantadine; Animals; Behavior, Animal; Cocaine; Drug Tolerance; Male; Rats; Rats, Sprague-Dawley; Substance Withdrawal Syndrome	1994
Desipramine and amantadine causing false-positive urine test for amphetamine. Annals of emergency medicine, 1993, Volume: 22, Issue:12 Topics: Adult; Amantadine; Amphetamine; Cocaine; Desipramine; False Positive Reactions; Humans; Male; Substance Abuse Detection	1993
Amantadine induces c-fos in rat striatum: reversal with dopamine D1 and NMDA receptor antagonists. European journal of pharmacology, 1995, Oct-16, Volume: 285, Issue:2 Topics: Amantadine; Animals; Cocaine; Dizocilpine Maleate; Dopamine Agents; Dopamine D2 Receptor Antagonists; Dopamine Uptake Inhibitors; Excitatory Amino Acid Antagonists; Immunohistochemistry; Male; Methamphetamine; Neostriatum; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate	1995
Antidepressant drugs inhibit glucocorticoid receptor-mediated gene transcription - a possible mechanism. British journal of pharmacology, 2000, Volume: 130, Issue:6 Topics: Amantadine; Animals; Antidepressive Agents; Cell Line, Transformed; Chloramphenicol O-Acetyltransferase; Cocaine; Corticosterone; Cyclic AMP; Cyclic GMP; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Estrenes; Gene Expression Regulation; Imipramine; Lithium Chloride; Memantine; Mifepristone; Protein Kinase Inhibitors; Pyrrolidinones; Receptors, Glucocorticoid; Receptors, Steroid; Sulfonamides; Tamoxifen; Thionucleotides; Time Factors; Transcription, Genetic; Type C Phospholipases	2000