amantadine and adamantane

amantadine has been researched along with adamantane in 74 studies

Research

Studies (74)

Timeframe	Studies, this research(%)	All Research%
pre-1990	38 (51.35)	18.7374
1990's	7 (9.46)	18.2507
2000's	9 (12.16)	29.6817
2010's	14 (18.92)	24.3611
2020's	6 (8.11)	2.80

Authors

Authors	Studies
Stone, TW	1
Bauer, DJ; Tisdale, M	1
Galasso, GJ; LaMontagne, JR	1
Hassett, CM; Mansfield, JI; Price, PJ	1
Dette-Wildenhahn, G; Fellehner, H; Wesemann, W	1
Kramer, MJ; Levitan, P; Tilley, JW	1
Fanta, D	1
Oxford, JS	1
Bigalke, H; Lampe, H	1
Bormann, J; Hübers, M; Kornhuber, J; Riederer, P; Rusche, K	1
Betts, RF	1
Belshe, RB; Burk, B; Cerruti, RL; Newman, F; Sim, IS	1
Donath, E; Donath, J; el-Karadagi, S; Glaser, R; Herrmann, A; Kharitonenkov, IG; Lentzsch, P; Tverdislov, VA	1
Coakley, WT; Donath, E; Egger, M; Groth, T; Herrmann, A; Taeger, M	1
Donath, E; Egger, M; Glaser, R; Ziemer, S	1
Blasecki, JW; Gaylord, JC; Hoffman, HE; Shalaby, LM; Whitney, CC	1
Hayden, FG; Tominack, RL	1
Spector, R	1
Garrino, MG; Henquin, JC	1
Jannasch, R	1
Bean, WJ; Kawaoka, Y; Webster, RG	1
Hayden, FG; Hoffman, HE; Minocha, A; Spyker, DA	1
Bean, WJ; Beard, CW; Brugh, M; Kawaoka, Y; Webster, RG	1
Döhner, L; Mentel, R; Panzig, B; Seidel, W	1
Gibb, W; Jeffery, J	1
Adamczyk, B; Feldblum, R; Heider, H; Indulen, MK; Presber, HW; Schroeder, C	1
Alonso, ML; Minguez, F; Moya, P; Ronda, E	1
Yaar, I	1
Bucher, DJ; El Karadaghi, S; Kharitonenkov, IG; Tverdislov, VA; Zakomirdin, JA	1
Sebastiani, A	1
Garcia Gil, M; Sanchez Crespo, M	1
Balda, BR; Przybilla, B; Wagner-Grösser, G	1
Hayden, FG; Hoffman, HE; Spyker, DA	1
Bryson, YJ; Dreisbach, M; Millet, VM	1
Dolin, R; Linton, PN; Madore, HP; Maynard, R; Reichman, RC; Webber-Jones, J	1
Burlington, DB; Meiklejohn, G; Mostow, SR	2
Cate, TR; Couch, RB; Goswick, CB; Quarles, JM	1
Adams, KF; Giordani, B; Gwaltney, JM; Hayden, FG; Van de Castle, RL	1
Kornhuber, J; Riederer, P; Schoppmeyer, K; Weller, M	1
Evans, SG; Havlik, I	1
Koshelev, S; Sobolevsky, A	1
Avdiunina, NI; Barchukov, VG; Ivanova, IA; Klimova, NV; Kovalev, GI; Morozov, IS; Piatin, BM; Sergeeva, SA	1
Alymova, IV; Bogdan, OP; Bukrinskaya, AG; Burstein, ME; Jdanov, VV; Khakhulina, TV; Manukchina, EE; Serbin, AV; Sharova, NK; Stotskaya, LL	1
Sobolevsky, AI; Yelshansky, MV	1
Vamvakidès, A	1
Borek-Dohalská, L; Frei, E; Hodek, P; Mráz, J; Stiborová, M	1
Bol'shakov, KV; Buldakova, SL; Gmiro, VE; Magazanik, LG; Samoilova, MV; Tikhonov, DB	1
Gebicka, L; Kochman, A; Metodiewa, D; Skolimowski, J	1
Lu, Q	1
Kelly, JM; Kolocouris, N; Papanastasiou, I; Prathalingam, SR; Tsotinis, A	1
De Clercq, E; Hay, AJ; Kolocouris, A; López-Querol, M; Martin, SR; Neyts, J; Padalko, E; Spearpoint, P; Sureda, FX	1
Arkin, IT; Astrahan, P	1
Antipova, TA; Kovalev, GI; Logvinov, IO; Zimin, IA	1
Arkin, IT; Astrahan, P; Krugliak, M; Leonov, H	1
Ivanova, EA; Kapitsa, IG; Kokshenev, II; Nepoklonov, AV; Val'dman, EA; Voronina, TA	1
Garibova, TL; Ivanova, EA; Kokshenev, II; Kotel'nikova, SO; Kraĭneva, VA; Nepoklonov, AV; Val'dman, EA; Voronina, TA	1
Ivanova, EA; Kapitsa, IG; Nepoklonov, AV; Val'dman, EA; Voronina, TA	1
Busath, DD; Cross, TA; Fedida, D; Johnson, FB; Kolocouris, A; Tietjen, I; Tzitzoglaki, C; Wright, AK; Zell, R	1
Berg, JD; Ford, LT	1
Antipova, TA; Logvinov, IO; Nepoklonov, AV; Valdman, EA	1
DeGrado, WF; Hu, Y; Ma, C; Musharrafieh, R; Smee, DF; Wang, J; Zhang, J	1
Boeckler, FM; Breitinger, HG; Breitinger, U; Ma, C; Mandour, YM; Wang, J; Zlotos, DP	1
Amentisch, H; Chountoulesi, M; Demetzos, C; Kiriakidi, S; Kolocouris, A; Kolokouris, D; Konstantinidi, A; Mali, G; Mavromoustakos, T; Naziris, N; Ntountaniotis, D; Sartori, B	1
Kolik, LG; Konstantinopolsky, MA	1
DeGrado, WF; Liu, L; Polizzi, N; Thomaston, JL; Wang, J; Wu, Y	1
Adotevi, N; Dabrowska, N; Joshi, S; Kapur, J; Lewczuk, E; Shan, S; Sun, H; Williamson, J	1
Grieb, P; Rejdak, K	1
Brenner, SR	1
Barbier, J; Cintrat, JC; Gillet, D; Huang, X; Jiang, C; Li, J; Liu, H; Sheng, R; Su, W; Sun, J; Wu, J; Wu, M; Wu, Y; Zhao, G	1
Barchanska, H; Kostina-Bednarz, M; Płonka, J	1
Aksinenko, AY; Bachurin, SO; Dubrovskaya, ES; Epishina, TA; Fisenko, VP; Goreva, TV; Grigoriev, VV; Lapshina, MA; Makhaeva, GF; Maleev, GV; Shevtsova, EF; Steinberg, DA; Ustyugov, AA; Veselov, IM; Vinogradova, DV; Zamoyski, VL	1

Reviews

7 review(s) available for amantadine and adamantane

Article	Year
Specific inhibitors of influenza virus replication as potential chemoprophylactic agents. The Journal of antimicrobial chemotherapy, 1975, Volume: 1, Issue:1 Topics: Adamantane; Amantadine; Animals; Antiviral Agents; DNA-Directed RNA Polymerases; Drug Resistance, Microbial; Humans; Influenza, Human; Models, Molecular; Orthomyxoviridae; Ribavirin; Virus Replication	1975
Amantadine and rimantadine for the prevention of influenza A. Seminars in respiratory infections, 1989, Volume: 4, Issue:4 Topics: Adamantane; Adult; Age Factors; Aged; Amantadine; Child; Humans; Influenza A virus; Influenza, Human; Rimantadine; Seasons; United States	1989
Rimantadine hydrochloride and amantadine hydrochloride use in influenza A virus infections. Infectious disease clinics of North America, 1987, Volume: 1, Issue:2 Topics: Adamantane; Adult; Aged; Amantadine; Humans; Influenza A virus; Influenza, Human; Rimantadine	1987
Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties. Journal of neural transmission. Supplementum, 1994, Volume: 43 Topics: Adamantane; Amantadine; Animals; Behavior, Animal; Dopamine; Electrophysiology; Hallucinogens; Humans; Memantine; Neuroprotective Agents; Receptors, N-Methyl-D-Aspartate; Substance-Related Disorders	1994
[Adamantane derivatives enhancing body's resistance to emergencies]. Vestnik Rossiiskoi akademii meditsinskikh nauk, 1999, Issue:3 Topics: Adamantane; Amantadine; Animals; General Adaptation Syndrome; Humans; Mice; Psychotropic Drugs; Rats; Stress, Psychological	1999
Antiviral therapy and prophylaxis for influenza in children. Pediatrics, 2007, Volume: 119, Issue:4 Topics: Adamantane; Amantadine; Antiviral Agents; Child; Child, Preschool; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Infant; Influenza, Human; Male; Oseltamivir; Primary Prevention; Prospective Studies; Randomized Controlled Trials as Topic; Rimantadine; Risk Assessment; Severity of Illness Index; Treatment Outcome; Zanamivir	2007
Resistance characteristics of influenza to amino-adamantyls. Biochimica et biophysica acta, 2011, Volume: 1808, Issue:2 Topics: Adamantane; Amantadine; Amino Acid Sequence; Drug Resistance, Viral; Genes, Viral; Hemagglutinin Glycoproteins, Influenza Virus; Humans; Influenza A virus; Influenza, Human; Ion Channels; Models, Molecular; Molecular Sequence Data; Mutation; Protein Stability; Protein Structure, Tertiary; Rimantadine; Sequence Homology, Amino Acid; Viral Matrix Proteins	2011

Trials

7 trial(s) available for amantadine and adamantane

Article	Year
From the National Institutes of Health. Report of a workshop on clinical studies of the efficacy of amantadine and rimantadine against influenza vireus. The Journal of infectious diseases, 1978, Volume: 138, Issue:6 Topics: Adamantane; Amantadine; Bridged-Ring Compounds; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; In Vitro Techniques; Influenza, Human; Michigan; National Institutes of Health (U.S.); Orthomyxoviridae; Placebos; United States	1978
[Treatment of herpes simplex using tromantadine hydrochloride]. Wiener medizinische Wochenschrift (1946), 1976, May-21, Volume: 126, Issue:20-22 Topics: Adamantane; Amantadine; Clinical Trials as Topic; Drug Evaluation; Drug Tolerance; Herpes Simplex; Humans	1976
Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrobial agents and chemotherapy, 1985, Volume: 28, Issue:2 Topics: Adamantane; Adult; Aged; Amantadine; Female; Humans; Kinetics; Male; Metabolic Clearance Rate; Mucus; Nasal Mucosa; Rimantadine	1985
Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics. Antimicrobial agents and chemotherapy, 1983, Volume: 23, Issue:3 Topics: Adamantane; Adult; Amantadine; Central Nervous System; Digestive System; Humans; Kinetics; Middle Aged; Rimantadine; Sleep	1983
Double-blind controlled study of central nervous system side effects of amantadine, rimantadine, and chlorpheniramine. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:1 Topics: Adamantane; Adolescent; Adult; Amantadine; Central Nervous System; Chlorpheniramine; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Male; Rimantadine	1982
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection. The New England journal of medicine, 1982, Sep-02, Volume: 307, Issue:10 Topics: Adamantane; Adolescent; Adult; Amantadine; Clinical Trials as Topic; Humans; Infant, Newborn; Influenza A virus; Influenza, Human; Middle Aged; Patient Compliance; Random Allocation; Rimantadine	1982
Comparative toxicity of amantadine hydrochloride and rimantadine hydrochloride in healthy adults. Antimicrobial agents and chemotherapy, 1981, Volume: 19, Issue:2 Topics: Adamantane; Adult; Amantadine; Central Nervous System Diseases; Gastrointestinal Diseases; Humans; Motor Skills; Rimantadine; Sleep Wake Disorders; Time Factors	1981

Other Studies

60 other study(ies) available for amantadine and adamantane

Article	Year
Comparison of neuronal responses to amantadine and rimantadine: use of alpha-flupenthixol. Experimental neurology, 1978, Volume: 62, Issue:2 Topics: Adamantane; Amantadine; Animals; Bridged-Ring Compounds; Cerebral Cortex; Dopamine Antagonists; Flupenthixol; Male; Neurons; Phentolamine; Propranolol; Rats; Synaptic Transmission; Thioxanthenes	1978
The relative potencies of anti-influenza compounds. Annals of the New York Academy of Sciences, 1977, Mar-04, Volume: 284 Topics: Adamantane; Amantadine; Amines; Animals; Antiviral Agents; Cells, Cultured; Cycloparaffins; Influenza A virus; Mice; Microbial Sensitivity Tests; Orthomyxoviridae Infections; Ribavirin	1977
Rimantadine but not amantadine protects Fischer rat embryo cells from transformation induced by 3-methylcholanthrene or benzo(a)pyrene. In vitro, 1979, Volume: 15, Issue:2 Topics: Adamantane; Amantadine; Animals; Benzopyrenes; Bridged-Ring Compounds; Cell Line; Cell Transformation, Neoplastic; Methylcholanthrene; Rats	1979
In vitro studies on the possible effects of 1-aminoadamantanes on the serotonergic system in M. Parkinson. Journal of neural transmission, 1979, Volume: 44, Issue:4 Topics: Adamantane; Amantadine; Animals; Biological Transport; Bridged-Ring Compounds; Electric Stimulation; Kinetics; Male; Parkinson Disease; Rats; Serotonin; Synapses; Synaptic Membranes; Synaptic Vesicles; Synaptosomes	1979
Adamantylthiourea derivatives as antiviral agents. Journal of medicinal chemistry, 1979, Volume: 22, Issue:8 Topics: Adamantane; Amantadine; Animals; Antiviral Agents; Lethal Dose 50; Mice; Orthomyxoviridae Infections; Thiourea	1979
Modulation of glycine-activated membrane current by adamantane derivatives. Neuroreport, 1991, Volume: 2, Issue:7 Topics: Adamantane; Amantadine; Animals; Cell Membrane; Cells, Cultured; Chloride Channels; Fetus; gamma-Aminobutyric Acid; Glycine; Ion Channels; Membrane Potentials; Membrane Proteins; Mice; Neurons; Spinal Cord	1991
Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study. European journal of pharmacology, 1991, Apr-25, Volume: 206, Issue:4 Topics: Adamantane; Amantadine; Binding Sites; Brain; Dizocilpine Maleate; Humans; Ion Channel Gating; Ion Channels; Kinetics; Memantine; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tritium	1991
Resistance of influenza A virus to amantadine and rimantadine: results of one decade of surveillance. The Journal of infectious diseases, 1989, Volume: 159, Issue:3 Topics: Adamantane; Amantadine; Animals; Antigens, Viral; Cell Line; Cytopathogenic Effect, Viral; Dogs; Drug Resistance; Enzyme-Linked Immunosorbent Assay; Humans; Influenza A virus; Influenza, Human; Rimantadine; Viral Plaque Assay	1989
Interaction of the antivirus agents remantadine and amantadine with lipid membranes and the influence on the curvature of human red cells. General physiology and biophysics, 1986, Volume: 5, Issue:1 Topics: Adamantane; Amantadine; Elasticity; Electron Spin Resonance Spectroscopy; Erythrocyte Deformability; Humans; Intracellular Membranes; Membrane Lipids; Rimantadine; Time Factors	1986
The influence of the antiviral drugs amantadine and rimantadine on erythrocyte and platelet membranes and its comparison with that of tetracaine. Biochemical pharmacology, 1987, Feb-15, Volume: 36, Issue:4 Topics: Adamantane; Amantadine; Antiviral Agents; Blood Platelets; Cell Fractionation; Electron Spin Resonance Spectroscopy; Erythrocyte Membrane; Hemagglutination, Viral; Humans; Osmotic Fragility; Platelet Aggregation; Rimantadine; Tetracaine	1987
Electrorotation--a new method for investigating membrane events during thrombocyte activation. Influence of drugs and osmotic pressure. Biochimica et biophysica acta, 1986, Sep-25, Volume: 861, Issue:1 Topics: Adamantane; Amantadine; Blood Platelets; Calcimycin; Cell Membrane; Chlorpromazine; Electrochemistry; Humans; Light; Mathematics; Osmotic Pressure; Platelet Aggregation; Rimantadine; Scattering, Radiation; Thrombin	1986
Pharmacokinetics and metabolism of rimantadine hydrochloride in mice and dogs. Antimicrobial agents and chemotherapy, 1988, Volume: 32, Issue:11 Topics: Adamantane; Administration, Oral; Amantadine; Animals; Biological Availability; Dogs; Dose-Response Relationship, Drug; Feces; Female; Gas Chromatography-Mass Spectrometry; Lung; Metabolic Clearance Rate; Mice; Orthomyxoviridae Infections; Rimantadine	1988
Transport of amantadine and rimantadine through the blood-brain barrier. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2 Topics: Adamantane; Amantadine; Animals; Biological Transport; Blood-Brain Barrier; Perfusion; Rats; Rats, Inbred Strains; Rimantadine	1988
Adamantane derivatives: a new class of insulin secretagogues. British journal of pharmacology, 1987, Volume: 90, Issue:3 Topics: Adamantane; Amantadine; Animals; Calcium; Female; Glucose; Hypoglycemic Agents; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice	1987
[Capillary isotachophoresis--a new method in drug analysis. 3. Analytic capillary isotachophoresis for the determination of amantadine and rimantadine]. Die Pharmazie, 1986, Volume: 41, Issue:7 Topics: Adamantane; Amantadine; Capsules; Electrophoresis; Rimantadine; Spectrophotometry, Ultraviolet; Tablets	1986
Vaccination as a strategy to reduce the emergence of amantadine- and rimantadine-resistant strains of A/Chick/Pennsylvania/83 (H5N2) influenza virus. The Journal of antimicrobial chemotherapy, 1986, Volume: 18 Suppl B Topics: Adamantane; Amantadine; Animals; Drug Resistance, Microbial; Influenza A virus; Influenza A Virus, H5N2 Subtype; Influenza Vaccines; Orthomyxoviridae Infections; Poultry; Poultry Diseases; Rimantadine; Vaccination	1986
Current status of amantadine and rimantadine as anti-influenza-A agents: memorandum from a WHO meeting. Bulletin of the World Health Organization, 1985, Volume: 63, Issue:1 Topics: Adamantane; Amantadine; Humans; Influenza A virus; Influenza, Human; Rimantadine	1985
Chemotherapy and vaccination: a possible strategy for the control of highly virulent influenza virus. Journal of virology, 1985, Volume: 55, Issue:1 Topics: Adamantane; Amantadine; Animals; Chickens; Drug Resistance, Microbial; Influenza A virus; Influenza in Birds; Rimantadine; Vaccination; Viral Vaccines	1985
[Action of antiviral substances on influenza viruses through the inhibition of neuraminidase production]. Archiv fur experimentelle Veterinarmedizin, 1985, Volume: 39, Issue:3 Topics: Adamantane; Amantadine; Animals; Chick Embryo; Culture Techniques; Fibroblasts; Influenza A virus; Neuraminidase; Rimantadine	1985
Reduction of the non-steroid adamantanone by crystalline preparations of cortisone reductase. The Biochemical journal, 1972, Volume: 126, Issue:2 Topics: Adamantane; Amantadine; Bridged-Ring Compounds; Catalysis; Cortisone; Cycloparaffins; Hydroxysteroid Dehydrogenases; Ketones; Ketosteroids; Kinetics; NAD; Oxidation-Reduction; Pregnanes; Spectrophotometry; Structure-Activity Relationship	1972
Occurrence of amantadine- and rimantadine-resistant influenza A virus strains during the 1980 epidemic. Acta virologica, 1981, Volume: 25, Issue:6 Topics: Adamantane; Amantadine; Drug Resistance, Microbial; Humans; Influenza A virus; Mutation; Rimantadine	1981
'In vivo' variations in serum interferon levels produced by antiviral compounds. Chemotherapy, 1983, Volume: 29, Issue:5 Topics: Adamantane; Amantadine; Animals; Chickens; Glucosamine; Interferons; Male; Mice; Mice, Inbred BALB C	1983
The effects of amantadine, rimantadine and levodopa on the frequency of fibrillation potentials in denervated muscle. Electroencephalography and clinical neurophysiology, 1984, Volume: 57, Issue:2 Topics: Acetylcholine; Adamantane; Amantadine; Animals; Electromyography; Levodopa; Muscle Contraction; Muscle Denervation; Rats; Receptors, Cholinergic; Rimantadine	1984
Interaction of influenza virus proteins with planar bilayer lipid membranes. II. Effects of rimantadine and amantadine. Biochimica et biophysica acta, 1984, Dec-05, Volume: 778, Issue:2 Topics: Adamantane; Amantadine; Dose-Response Relationship, Drug; Kinetics; Lipid Bilayers; Membrane Potentials; Phosphatidylcholines; Phospholipids; Rimantadine; Viral Matrix Proteins; Viral Proteins	1984
[Amantadine and riamantadine in the treatment of influenza]. Recenti progressi in medicina, 1983, Volume: 74, Issue:3 Topics: Adamantane; Amantadine; Humans; Influenza, Human; Rimantadine	1983
Dansylcadaverine and rimantadine inhibition of phagocytosis, PAF-acether release, and phosphatidylcholine synthesis in human polymorphonuclear leukocytes. Immunopharmacology, 1983, Volume: 6, Issue:4 Topics: Adamantane; Amantadine; Antineoplastic Agents; Cadaverine; Diamines; Humans; Neutrophils; Phagocytosis; Phosphatidylcholines; Platelet Activating Factor; Rimantadine	1983
[Contact-allergic cross-reactions of tromantadine and amantadine]. Deutsche medizinische Wochenschrift (1946), 1983, Feb-04, Volume: 108, Issue:5 Topics: Adamantane; Adult; Amantadine; Cross Reactions; Dermatitis, Contact; Drug Hypersensitivity; Female; Humans; Male; Middle Aged	1983
Anti-influenza A virus activity of amantadine hydrochloride and rimantadine hydrochloride in ferret tracheal ciliated epithelium. Antimicrobial agents and chemotherapy, 1982, Volume: 21, Issue:5 Topics: Adamantane; Amantadine; Animals; Cilia; Cytopathogenic Effect, Viral; Epithelium; Ferrets; In Vitro Techniques; Influenza A virus; Rimantadine; Time Factors; Trachea; Virus Cultivation	1982
Toxicity of amantadine and rimantadine for the ciliated epithelium of ferret tracheal rings. The Journal of infectious diseases, 1981, Volume: 144, Issue:1 Topics: Adamantane; Amantadine; Animals; Cilia; Ferrets; In Vitro Techniques; Rimantadine; Trachea	1981
Comparison of amantadine and rimantadine for prevention of type A (Russian) influenza. Antiviral research, 1981, Volume: 1, Issue:3 Topics: Adamantane; Adolescent; Adult; Age Factors; Amantadine; Antibodies, Viral; Double-Blind Method; Drug Evaluation; Female; Humans; Influenza A virus; Influenza, Human; Male; Rimantadine	1981
Effect of pH on in vitro potency of amantadine against Plasmodium falciparum. The American journal of tropical medicine and hygiene, 1996, Volume: 54, Issue:3 Topics: Adamantane; Amantadine; Ammonium Chloride; Animals; Antimalarials; Chloroquine; Culture Media; Dose-Response Relationship, Drug; Drug Resistance; Humans; Hydrogen-Ion Concentration; Mefloquine; Plasmodium falciparum; Quinine	1996
Two blocking sites of amino-adamantane derivatives in open N-methyl-D-aspartate channels. Biophysical journal, 1998, Volume: 74, Issue:3 Topics: Adamantane; Amantadine; Animals; Binding Sites; Cell Membrane; Cell Separation; Hippocampus; In Vitro Techniques; Kinetics; Memantine; Membrane Potentials; Models, Chemical; Models, Molecular; Patch-Clamp Techniques; Pyramidal Cells; Rats; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship	1998
Inhibition of HIV-1 replication by newly developed adamantane-containing polyanionic agents. Antiviral research, 1999, Volume: 41, Issue:3 Topics: Adamantane; Anti-HIV Agents; Cell Line; Drug Design; HIV Core Protein p24; HIV-1; Humans; Immunoblotting; Jurkat Cells; Viral Proteins; Virus Replication	1999
The trapping block of NMDA receptor channels in acutely isolated rat hippocampal neurones. The Journal of physiology, 2000, Aug-01, Volume: 526 Pt 3 Topics: Adamantane; Amantadine; Animals; Antiparkinson Agents; Aspartic Acid; Cell Separation; Dopamine Agents; Dose-Response Relationship, Drug; Hippocampus; In Vitro Techniques; Ion Channels; Magnesium; Membrane Potentials; Neurons; Patch-Clamp Techniques; Perfusion; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	2000
[Effect of amantadine or 3-cyclopentyl adamantanamine on the immobility of adult or aged mice, in the forced swim test]. Annales pharmaceutiques francaises, 2000, Volume: 58, Issue:6 Topics: Adamantane; Aging; Amantadine; Animals; Antiparkinson Agents; Brain; Imipramine; Male; Mice; Mice, Inbred BALB C; Restraint, Physical; Stress, Psychological; Swimming	2000
New selective inhibitors of cytochromes P450 2B and their application to antimutagenesis of tamoxifen. Archives of biochemistry and biophysics, 2002, Jul-01, Volume: 403, Issue:1 Topics: Adamantane; Amantadine; Animals; Antineoplastic Agents; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 Enzyme Inhibitors; DNA Adducts; Endometrial Neoplasms; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Inhibitory Concentration 50; Kinetics; Microsomes; Models, Chemical; Mutagens; Oxygen; Rabbits; Steroid Hydroxylases; Tamoxifen	2002
Studies of the structure of glutamate receptor ion channels and the mechanisms of their blockade by organic cations. Neuroscience and behavioral physiology, 2003, Volume: 33, Issue:3 Topics: Adamantane; Amantadine; Animals; Animals, Newborn; Brain; Cations; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; In Vitro Techniques; Ion Channels; Models, Biological; Models, Molecular; Neurons; Patch-Clamp Techniques; Quaternary Ammonium Compounds; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate	2003
Synthesis and antioxidant activity evaluation of novel antiparkinsonian agents, aminoadamantane derivatives of nitroxyl free radical. Bioorganic & medicinal chemistry, 2003, Aug-05, Volume: 11, Issue:16 Topics: Adamantane; Amantadine; Animals; Antioxidants; Antiparkinson Agents; Brain; Dopamine; Female; Free Radicals; Immunohistochemistry; Molecular Structure; Nitrogen Oxides; Parkinsonian Disorders; Piperidines; Rats; Rats, Inbred BUF; Reactive Oxygen Species; Spectrophotometry; Tyrosine 3-Monooxygenase	2003
[Treatment of influenza in children]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2003, Volume: 41, Issue:2 Topics: Adamantane; Amantadine; Antiviral Agents; Child; Guanidines; Humans; Influenza, Human; Pyrans; Rimantadine; Sialic Acids; Zanamivir	2003
Design, synthesis, and trypanocidal activity of new aminoadamantane derivatives. Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5 Topics: Adamantane; Amantadine; Animals; Parasitic Sensitivity Tests; Rimantadine; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma brucei brucei	2008
Comparisons of the influenza virus A M2 channel binding affinities, anti-influenza virus potencies and NMDA antagonistic activities of 2-alkyl-2-aminoadamantanes and analogues. Bioorganic & medicinal chemistry letters, 2008, Dec-01, Volume: 18, Issue:23 Topics: Adamantane; Amantadine; Antiviral Agents; Influenza A virus; Molecular Structure; N-Methylaspartate; Structure-Activity Relationship; Viral Matrix Proteins	2008
[A comparative study of hemantane and amantadine effects on dopamine transporter expression in brain of normal and MPTP-treated C57BL/6 mice]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:1 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Amantadine; Animals; Antiparkinson Agents; Brain; Dopamine Plasma Membrane Transport Proteins; Drug Synergism; Male; Mice; Mice, Inbred C57BL; Parkinsonian Disorders	2011
How do aminoadamantanes block the influenza M2 channel, and how does resistance develop? Journal of the American Chemical Society, 2011, Jun-29, Volume: 133, Issue:25 Topics: Adamantane; Amantadine; Antiviral Agents; Binding Sites; Drug Resistance, Viral; Humans; Ion Channels; Mutation; Rimantadine; Static Electricity; Viral Matrix Proteins	2011
[Comparative study of amantadine and hemantane effects on development of levodopa-induced dyskinesia in rat model of parkinsonian syndrome]. Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:7 Topics: Adamantane; Amantadine; Animals; Behavior, Animal; Benserazide; Disease Models, Animal; Dyskinesia, Drug-Induced; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Rats; Substantia Nigra	2011
[Comparative study of himantane and amantadine effects in experimental intracerebral posttraumatic hematoma]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:9 Topics: Adamantane; Amantadine; Animals; Antiparkinson Agents; Cerebral Hemorrhage, Traumatic; Disease Models, Animal; Exploratory Behavior; Male; Memory; Muscle Tonus; Rats	2012
[Study of hemantane effects in rats on a model of early (premotor) stage of Parkinson's disease]. Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:11 Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Adamantane; Amantadine; Animals; Antiparkinson Agents; Cognition; Drug Administration Schedule; Male; Neurotoxins; Parkinson Disease, Secondary; Rats; Time Factors	2012
Aminoadamantanes with persistent in vitro efficacy against H1N1 (2009) influenza A. Journal of medicinal chemistry, 2014, Jun-12, Volume: 57, Issue:11 Topics: Adamantane; Amantadine; Animals; Antiviral Agents; Dogs; Drug Resistance, Multiple, Viral; HEK293 Cells; Humans; Influenza A Virus, H1N1 Subtype; Ion Channels; Madin Darby Canine Kidney Cells; Mutation; Rimantadine; Viral Matrix Proteins	2014
1-Adamantylamine a simple urine marker for screening for third generation adamantyl-type synthetic cannabinoids by ultra-performance liquid chromatography tandem mass spectrometry. Annals of clinical biochemistry, 2016, Volume: 53, Issue:6 Topics: Adamantane; Adult; Amantadine; Cannabinoids; Chromatography, High Pressure Liquid; Female; Humans; Illicit Drugs; Indazoles; Indoles; Limit of Detection; Male; Substance Abuse Detection; Tandem Mass Spectrometry; United Kingdom	2016
[COMPARISON OF CYTOPROTECTIVE EFFECTS OF HEMANTANE AND AMANTADINE UNDER CONDITIONS OF 6-HYDROXYDOPAMINE NEUROTOXIN ACTION ON CULTURED HUMAN NEUROBLASTOMA CELLS]. Eksperimental'naia i klinicheskaia farmakologiia, 2016, Volume: 79, Issue:1 Topics: Adamantane; Amantadine; Cell Line, Tumor; Cytoprotection; Dose-Response Relationship, Drug; Humans; Models, Biological; Neuroblastoma; Parkinsonian Disorders	2016
An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses. Antiviral research, 2017, Volume: 140 Topics: Adamantane; Amantadine; Animals; Antiviral Agents; Dogs; Drug Resistance, Viral; Humans; Influenza A virus; Influenza, Human; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Molecular Dynamics Simulation; Mutation; Orthomyxoviridae Infections; Spiro Compounds; Structure-Activity Relationship; Viral Matrix Proteins	2017
Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7. Drug design, development and therapy, 2018, Volume: 12 Topics: Adamantane; Amantadine; Antiviral Agents; Cells, Cultured; Drug Design; HEK293 Cells; Humans; Models, Molecular; Molecular Structure; Rimantadine; Viral Matrix Proteins; Viral Proteins	2018
Comparative Perturbation Effects Exerted by the Influenza A M2 WT Protein Inhibitors Amantadine and the Spiro[pyrrolidine-2,2'-adamantane] Variant AK13 to Membrane Bilayers Studied Using Biophysical Experiments and Molecular Dynamics Simulations. The journal of physical chemistry. B, 2018, 11-01, Volume: 122, Issue:43 Topics: Adamantane; Amantadine; Binding Sites; Calorimetry, Differential Scanning; Dimyristoylphosphatidylcholine; Influenza A virus; Lipid Bilayers; Magnetic Resonance Spectroscopy; Molecular Dynamics Simulation; Nuclear Magnetic Resonance, Biomolecular; Scattering, Small Angle; Viral Matrix Proteins; X-Ray Diffraction	2018
Comparative Assessment of the Effectiveness of Noncompetitive NMDA Receptor Antagonists Amantadine and Hemantane in Morphine Withdrawal Syndrome Model. Bulletin of experimental biology and medicine, 2019, Volume: 166, Issue:6 Topics: Adamantane; Amantadine; Animals; Gene Expression; Hyperalgesia; Injections, Intraperitoneal; Male; Morphine; Morphine Dependence; Motor Activity; Narcotic Antagonists; Rats; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome; Weight Loss	2019
X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case. Journal of the American Chemical Society, 2019, 07-24, Volume: 141, Issue:29 Topics: Adamantane; Amantadine; Asparagine; Binding Sites; Crystallography, X-Ray; Drug Resistance, Viral; Hydrogen Bonding; Hydrogen-Ion Concentration; Influenza A virus; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Viral Matrix Proteins	2019
α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor Plasticity Sustains Severe, Fatal Status Epilepticus. Annals of neurology, 2020, Volume: 87, Issue:1 Topics: Adamantane; Amantadine; Animals; Atropine; CA1 Region, Hippocampal; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gene Knockdown Techniques; Hippocampus; Male; Mice; Mice, Knockout; Neuronal Plasticity; Receptors, AMPA; Status Epilepticus; Synaptic Transmission	2020
Adamantanes might be protective from COVID-19 in patients with neurological diseases: multiple sclerosis, parkinsonism and cognitive impairment. Multiple sclerosis and related disorders, 2020, Volume: 42 Topics: Adamantane; Adult; Aged; Aged, 80 and over; Amantadine; Asymptomatic Infections; Betacoronavirus; Cognitive Dysfunction; Coronavirus Infections; COVID-19; Dopamine Agents; Female; Humans; Male; Memantine; Middle Aged; Multiple Sclerosis; Pandemics; Parkinson Disease; Pneumonia, Viral; Protective Factors; SARS-CoV-2; Severity of Illness Index	2020
The potential of memantine and related adamantanes such as amantadine, to reduce the neurotoxic effects of COVID-19, including ARDS and to reduce viral replication through lysosomal effects. Journal of medical virology, 2020, Volume: 92, Issue:11 Topics: Adamantane; Amantadine; COVID-19; Humans; Lysosomes; Memantine; Respiratory Distress Syndrome; Respiratory Insufficiency; SARS-CoV-2; Virus Replication	2020
Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy. International journal of molecular sciences, 2022, Apr-01, Volume: 23, Issue:7 Topics: Adamantane; Amantadine; Animals; Antiviral Agents; Autophagy; Endosomes; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Mice; Molecular Docking Simulation; p-Dimethylaminoazobenzene	2022
Metabolic profiling to evaluate the impact of amantadine and rimantadine on the secondary metabolism of a model organism. Scientific reports, 2023, 10-05, Volume: 13, Issue:1 Topics: Adamantane; Amantadine; Metabolic Clearance Rate; Rimantadine; Secondary Metabolism	2023
New Adamantane-Containing Edaravone Conjugates as Potential Neuroprotective Agents for ALS Treatments. Molecules (Basel, Switzerland), 2023, Nov-13, Volume: 28, Issue:22 Topics: Adamantane; Amantadine; Amyotrophic Lateral Sclerosis; Edaravone; Humans; Neuroprotective Agents; Riluzole	2023