am 251 and sr141716
am 251 has been researched along with sr141716 in 87 studies
Research
Studies (87)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (3.45) | 18.2507 |
| 2000's | 48 (55.17) | 29.6817 |
| 2010's | 35 (40.23) | 24.3611 |
| 2020's | 1 (1.15) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Fan, P; Fernando, SR; Lan, R; Lin, S; Liu, Q; Makriyannis, A; McCallion, D; Pertwee, R | 1 |
| Cartier, E; Edwards, JL; Howlett, AC; Shim, JY; Welsh, WJ | 1 |
| Caulder, T; Hoffman, AF; Horti, AG; Katoch-Rouse, R; Mukhin, AG; Pavlova, OA | 1 |
| Botta, M; Brizzi, A; Cascio, MG; Corelli, F; Di Marzo, V; La Regina, G; Lavecchia, A; Novellino, E; Pasquini, S; Piscitelli, F; Silvestri, R | 1 |
| Ball, RG; Castonguay, LA; Doss, GA; Fong, TM; Goulet, MT; Ha, S; Hagmann, WK; Lin, LS; Shen, CP; Tsou, NN; Xiao, JC | 1 |
| Bisogno, T; Cascio, MG; Di Marzo, V; Ramunno, A; Saturnino, C; Urbani, P | 1 |
| Allarà, M; Brizzi, A; Carai, MA; Colombo, G; Corelli, F; Di Marzo, V; Fantini, N; Gatti, V; La Regina, G; Lavecchia, A; Ligresti, A; Novellino, E; Pasquini, S; Piscitelli, F; Silvestri, R | 1 |
| Arthur, S; Balenga, NA; Henstridge, CM; Irving, AJ; Kargl, JK; Kostenis, E; Martini, L; Penman, J; Platzer, W; Schröder, R; Waldhoer, M; Whistler, JL | 1 |
| Allarà, M; Bigogno, C; Brizzi, A; Carai, MA; Colombo, G; Corelli, F; Di Marzo, V; Dondio, G; Fantini, N; Gatti, V; La Regina, G; Lavecchia, A; Ligresti, A; Novellino, E; Pasquini, S; Piscitelli, F; Rozio, MG; Silvestri, R; Sinisi, R | 1 |
| Brogi, S; Corelli, F; Di Marzo, V; Ligresti, A; Mugnaini, C; Pasquini, S; Tafi, A | 1 |
| Decara, J; Elguero, J; Fresno, N; Girón, R; Goya, P; Macías-González, M; Martín, MI; Pérez-Fernández, R; Rodríguez de Fonseca, F; Rodríguez-Álvarez, A | 1 |
| Decker, M; Heilmann, J; Huang, G; Nimczick, M; Pemp, D; Stadtmüller, P | 1 |
| Bánki, L; Deli, MA; Dvorácskó, S; Horváth, G; Kékesi, G; Keresztes, A; Macedonio, G; Mollica, A; Pieretti, S; Stefanucci, A; Tömböly, C; Tuboly, G; Walter, FR; Zádor, F | 1 |
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Volkow, ND | 1 |
| Andrenyak, DM; Deng, H; Dey, SK; Ma, W; Makriyannis, A; Moody, DE; Paria, BC; Schmid, HH; Schmid, PC | 1 |
| Díaz-Laviada, I; Ruiz, L; Sánchez, MG; Velasco, L | 1 |
| Gitlin, JM; Mitchell, JA; Stanford, SJ | 1 |
| Bottrill, FE; Ford, WR; Hiley, CR; Ho, WS; White, R | 1 |
| Köfalvi, A; Ledent, C; Sperlágh, B; Vizi, ES | 1 |
| Järvinen, T; Laitinen, JT; Niemi, R; Saario, SM; Savinainen, JR | 1 |
| Brotchie, JM; Brown, TM; Fitzjohn, SM | 1 |
| Dougalis, A; Lees, G | 1 |
| Bátkai, S; Járai, Z; Kunos, G; Pacher, P; Wagner, JA | 1 |
| Mendiguren, A; Pineda, J | 2 |
| Freund, TF; Haller, J; Ledent, C; Varga, B | 1 |
| Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA | 1 |
| Cole, RB; Ma, P; Wang, G; Wang, W; Zhang, Q | 1 |
| Pertwee, RG | 1 |
| Cunha, RA; Köfalvi, A; Ledent, C; Mackie, K; Rodrigues, RJ; Sperlágh, B; Vizi, ES | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Nomikos, GG; Panagis, G; Vlachou, S | 1 |
| Hoffman, AF; Lupica, CR; Macgill, AM; Oz, M; Smith, D | 1 |
| Järbe, TU; Liu, Q; Makriyannis, A | 1 |
| Fukaya, M; Kano, M; Kawamura, Y; Maejima, T; Miura, E; Ohno-Shosaku, T; Watanabe, M; Yoshida, T | 1 |
| Cheer, JF; Wassum, KM; Wightman, RM | 1 |
| Cunha, RA; Davis, RJ; Degroot, A; Köfalvi, A; Nomikos, GG; Rebola, N; Rodrigues, RJ; Wade, MR | 1 |
| Liu, C; Walker, JM | 1 |
| McMahon, LR | 1 |
| Blair, RE; Carter, DS; DeLorenzo, RJ; Deshpande, LS; Martin, BR; Sombati, S | 1 |
| Su, JY; Vo, AC | 1 |
| Ballmaier, M; Bortolato, M; Gessa, G; Heinz, A; Rizzetti, C; Spano, P; Zoli, M | 1 |
| Koek, W; McMahon, LR | 1 |
| Dillon, C; Gardner, EL; Gilbert, J; Li, X; Pak, AC; Peng, XQ; Spiller, K; Xi, ZX | 1 |
| Cachope, R; Mackie, K; O'Brien, J; Pereda, AE; Triller, A | 1 |
| Brunell, S; McCulloch, M; Spear, L; Xu, Y; Zhou, X | 1 |
| Ma, YL; Stephens, GJ; Weston, SE; Whalley, BJ | 1 |
| Bifulco, M; Gazzerro, P; Laezza, C; Malfitano, AM; Pisanti, S; Santoro, A | 1 |
| Ferrara, M; Mathes, CM; Rowland, NE | 1 |
| Aubin, HJ; Forget, B; Goldberg, SR; Le Foll, B | 1 |
| Itakura, C; Katayama, M; Niimi, K; Takahashi, E | 1 |
| Hasenöhrl, RU; Ledent, C; Molleman, A; Thiemann, G; Watt, CA | 1 |
| Ameloot, K; Boesmans, W; Tack, J; van den Abbeel, V; Vanden Berghe, P | 1 |
| Hou, LC; Ji, GL; Li, N; Lu, Y; Wang, YM; Xie, KL; Xiong, LZ; Zheng, LN | 1 |
| Allen, CP; Lang, ST; Leri, F; Manwell, LA; Parker, LA; Satvat, E | 1 |
| Abood, ME; Bai, Y; Barak, LS; Caron, MG; Kapur, A; Sharir, H; Zhao, P | 1 |
| Bhat, M; Bowen, WD; Cheng, J; Liu, Q | 1 |
| Clapper, JR; Eisenstein, SA; Hohmann, AG; Holmes, PV; Piomelli, D | 1 |
| Gilman, JP; Goldberg, SR; Justinova, Z; Makriyannis, A; Panlilio, LV; Schindler, CW; Vemuri, VK | 1 |
| Bashashati, M; Duncan, M; Hirota, C; Keenan, CM; Lutz, B; Mackie, K; Macnaughton, WK; Makriyannis, A; Sharkey, KA; Storr, MA; Vemuri, VK | 1 |
| Alger, BE; Kim, J | 1 |
| Dodd, GT; Luckman, SM; Lutz, B; Mancini, G | 1 |
| Makwana, R; Molleman, A; Parsons, ME | 1 |
| Hillard, CJ; Ho, WS; Patel, S; Roberts, CJ; Stuhr, KL; Thompson, JR | 1 |
| Karr, L; Pan, YZ; Rutecki, PA | 1 |
| Dowd, E; Finn, DP; Gorman, AM; Walsh, S | 1 |
| Baur, R; Gertsch, J; Sigel, E | 1 |
| Raffa, RB; Ward, SJ | 1 |
| Bisset, KM; Dhopeshwarkar, AS; Liao, C; Nicholson, RA | 1 |
| Bonci, A; Hopf, FW; Kunos, G; Makriyannis, A; Seif, T | 1 |
| Bialuk, I; Winnicka, MM | 1 |
| Armstrong, WE; Wang, L | 1 |
| Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M | 1 |
| Brents, LK; Fantegrossi, WE; Franks, LN; Prather, PL; Rajasekaran, M; Seely, KA; Zimmerman, SM | 1 |
| Balla, A; Catt, KJ; Hunyady, L; Nádasy, GL; Soltész-Katona, E; Szekeres, M; Tóth, ZE; Turu, G | 1 |
| Bartsch, D; Bénard, G; Chaouloff, F; Dubreucq, S; Durand, A; Georges, F; Glangetas, C; Groc, L; Marsicano, G; Massa, F; Matias, I; Richard, E; Soria-Gomez, E; Wadleigh, A | 1 |
| Aguiar, DC; Campos, AC; Díaz-Alonso, J; Fogaça, MV; Galve-Roperh, I; Guimarães, FS; Guzmán, M; Moreira, FA; Ortega, Z; Ortega-Gutiérrez, S; Palazuelos, J; Vázquez-Villa, H | 1 |
| Giuffrida, A; Martinez, AA; Seillier, A | 1 |
| Duncan, M; Parker, LA; Rock, EM; Sticht, MA; Stott, C | 1 |
| Abbas, Z; Arvanitogiannis, A; Bernstein, DL; Cheer, JF; Gentry, RN; Hernandez, G; Oleson, EB | 1 |
| Castiglione, F; Füllhase, C; Giese, A; Gratzke, C; Hedlund, P; La Croce, G; Montorsi, F; Schmidt, M; Schreiber, A; Stief, C | 1 |
| Gao, F; Ji, M; Li, F; Li, Q; Miao, Y; Qian, WJ; Sun, XH; Wang, SY; Wang, Z; Yang, W | 1 |
| Cortesi, R; Drechsler, M; Esposito, E; Nastruzzi, C | 1 |
| Dang, DK; Jang, CG; Jeong, JH; Kim, HC; Ledent, C; Mai, AT; Nabeshima, T; Nah, SY; Onaivi, ES; Shin, EJ; Yamamoto, T | 1 |
| Cheng, J; Jiang, C; Wu, J; Yu, J; Zhou, X; Zong, Y | 1 |
| Crews, FT; Grant, ML; Jones, VM; Khatri, D; Laroche, G; Mukhopadhyay, S; Vetreno, RP | 1 |
| Atanes, P; Choudhary, P; Huang, GC; Liu, B; Persaud, SJ; Pingitore, A; Ruz-Maldonado, I | 1 |
Reviews
3 review(s) available for am 251 and sr141716
| Article | Year |
|---|---|
Inverse agonism and neutral antagonism at cannabinoid CB1 receptors.
Topics: Animals; Benzofurans; Cannabinoids; Morpholines; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Blocking cannabinoid CB1 receptors for the treatment of nicotine dependence: insights from pre-clinical and clinical studies.
Topics: Animals; Brain; Cannabinoid Receptor Modulators; Clinical Trials as Topic; Drug Evaluation, Preclinical; Emotions; Humans; Motivation; Nicotine; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Secondary Prevention; Smoking Cessation; Tobacco Use Disorder | 2008 |
CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Dronabinol; Humans; Ligands; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant | 2012 |
Other Studies
84 other study(ies) available for am 251 and sr141716
| Article | Year |
|---|---|
Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists.
Topics: Animals; Cannabinoids; Guinea Pigs; Humans; In Vitro Techniques; Intestine, Small; Male; Mice; Muscle Contraction; Muscle, Smooth; Myenteric Plexus; Piperidines; Prosencephalon; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Spleen; Structure-Activity Relationship; Vas Deferens | 1999 |
Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor.
Topics: Algorithms; Animals; Brain; Kinetics; Ligands; Models, Chemical; Models, Molecular; Naphthalenes; Piperidines; Protein Binding; Protein Conformation; Protons; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Software; Structure-Activity Relationship | 2002 |
Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity.
Topics: Animals; Benzoxazines; Cannabinoids; Cerebellum; In Vitro Techniques; Ligands; Membrane Potentials; Morpholines; Naphthalenes; Nucleus Accumbens; Piperidines; Pyrazoles; Radioligand Assay; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship; Tomography, Emission-Computed | 2003 |
Synthesis, cannabinoid receptor affinity, and molecular modeling studies of substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides.
Topics: Binding, Competitive; Computer Simulation; Humans; Hydrogen Bonding; Ligands; Models, Molecular; Molecular Structure; Pyrazoles; Pyrroles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Structure-Activity Relationship | 2008 |
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
Topics: Amides; Amino Acid Sequence; Animals; Binding Sites; Cells, Cultured; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Crystallography, X-Ray; Humans; Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Pyridines; Receptor, Cannabinoid, CB1; Reference Standards; Sequence Alignment; Structure-Activity Relationship | 2008 |
Novel sterically hindered cannabinoid CB1 receptor ligands.
Topics: Acetamides; Animals; Cell Line, Tumor; Ligands; Mice; Molecular Structure; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2008 |
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity
Topics: Animals; Binding Sites; Computer Simulation; Drinking; Eating; Humans; Ligands; Male; Models, Molecular; Protein Binding; Pyrroles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2009 |
GPR55 ligands promote receptor coupling to multiple signalling pathways.
Topics: Biological Assay; Cannabinoids; Cell Line, Transformed; Endocytosis; Humans; Ligands; Lysophospholipids; Morpholines; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Signal Transduction | 2010 |
Synthesis and biological evaluation of new N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides as cannabinoid receptor ligands.
Topics: Amides; Animals; Dose-Response Relationship, Drug; Eating; Humans; Ligands; Male; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recombinant Proteins; Structure-Activity Relationship | 2010 |
Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.
Topics: Computer Simulation; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Quinolones; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Stereoisomerism | 2011 |
Discovery of Potent Dual PPARα Agonists/CB1 Ligands.
Topics: | 2011 |
Design, synthesis and in vitro evaluation of novel uni- and bivalent ligands for the cannabinoid receptor type 1 with variation of spacer length and structure.
Topics: Amides; Amines; Cannabinoid Receptor Agonists; Carboxylic Acids; Dose-Response Relationship, Drug; Drug Design; Humans; Ligands; Molecular Structure; Receptor, Cannabinoid, CB1; Structure-Activity Relationship | 2014 |
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalins; Indoles; Mice; Molecular Structure; Naphthalenes; Oxycodone; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Structure-Activity Relationship | 2019 |
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
Topics: Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dronabinol; Hippocampus; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tissue Distribution | 1996 |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.
Topics: Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Male; Nerve Growth Factor; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
Identification of two distinct vasodilator pathways activated by ATP in the mesenteric bed of the rat.
Topics: Adenine; Adenosine; Adenosine Triphosphate; Animals; Arachidonic Acids; Capsaicin; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Enzyme Inhibitors; Guanylate Cyclase; Histamine; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Piperidines; Polyunsaturated Alkamides; Potassium Chloride; Pyrazoles; Pyrilamine; Quinoxalines; Rats; Rats, Wistar; Rimonabant; Signal Transduction; Stereoisomerism; Theophylline; Vasodilation | 2001 |
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.
Topics: Amides; Animals; Arachidonic Acids; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Gap Junctions; Glycyrrhetinic Acid; In Vitro Techniques; Indoles; Indomethacin; Male; Palmitic Acids; Peptides; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Tetraethylammonium; Vasodilation | 2001 |
Cannabinoids inhibit the release of [3H]glutamate from rodent hippocampal synaptosomes via a novel CB1 receptor-independent action.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Chromatography, High Pressure Liquid; Cyclohexanols; Dose-Response Relationship, Drug; Drug Interactions; Glutamic Acid; Hippocampus; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Radioactivity; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synaptosomes; Tritium | 2003 |
An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors.
Topics: Adenosine A1 Receptor Antagonists; Adenosine Deaminase; Animals; Arachidonic Acids; Cerebellum; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Organophosphonates; Piperidines; Pyrazoles; Radioligand Assay; Rats; Rats, Wistar; Receptor, Adenosine A1; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2003 |
Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake.
Topics: Amino Acids; Animals; Cannabinoids; Cerebral Cortex; Corpus Striatum; Dronabinol; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission; Xanthenes | 2003 |
Differential effects of the sleep-inducing lipid oleamide and cannabinoids on the induction of long-term potentiation in the CA1 neurons of the rat hippocampus in vitro.
Topics: Amidohydrolases; Analysis of Variance; Animals; Animals, Newborn; Arachidonic Acids; Benzoxazines; Cannabinoids; Capsaicin; Drug Interactions; Electric Stimulation; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Long-Term Potentiation; Male; Morpholines; Naphthalenes; Neurons; Oleic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant; Sleep | 2004 |
Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors.
Topics: Animals; Cannabinoids; Endotoxins; Heart; Heart Rate; Hemodynamics; Hypotension; Male; Mice; Mice, Knockout; Myocardial Contraction; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Vascular Resistance | 2004 |
Cannabinoids enhance N-methyl-D-aspartate-induced excitation of locus coeruleus neurons by CB1 receptors in rat brain slices.
Topics: Action Potentials; Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cyclohexanols; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; In Vitro Techniques; Locus Coeruleus; Male; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
CB1 cannabinoid receptors mediate anxiolytic effects: convergent genetic and pharmacological evidence with CB1-specific agents.
Topics: Animals; Anti-Anxiety Agents; Behavior, Animal; Benzoxazines; Dose-Response Relationship, Drug; Drug Synergism; Male; Maze Learning; Mice; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
In vitro metabolism of diarylpyrazoles, a novel group of cannabinoid receptor ligands.
Topics: Animals; Chromatography, High Pressure Liquid; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mass Spectrometry; Microsomes, Liver; Morpholines; Piperidines; Pyrazoles; Rats; Receptors, Cannabinoid; Rimonabant | 2005 |
Involvement of cannabinoid receptors in the regulation of neurotransmitter release in the rodent striatum: a combined immunochemical and pharmacological analysis.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzoxazines; Blotting, Western; Calcium; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Immunohistochemistry; Male; Mice; Mice, Knockout; Morpholines; Naphthalenes; Neurotransmitter Agents; Piperidines; Potassium; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptosomes; Tetrodotoxin; Tritium; Tyrosine 3-Monooxygenase; Vesicular Glutamate Transport Protein 1; Vesicular Glutamate Transport Protein 2 | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat.
Topics: Animals; Benzoxazines; Brain; Dronabinol; Electrodes, Implanted; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2005 |
Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus.
Topics: Adenosine; Analgesics; Animals; Benzoxazines; Calcium Channel Blockers; Electric Stimulation; Excitatory Postsynaptic Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Time Factors | 2005 |
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Topics: Animals; Arachidonic Acids; Camphanes; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism | 2006 |
The CB1 cannabinoid receptor is the major cannabinoid receptor at excitatory presynaptic sites in the hippocampus and cerebellum.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Action Potentials; Animals; Benzoxazines; Cerebellar Cortex; Female; Hippocampus; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Immunoelectron; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Presynaptic Terminals; Purkinje Cells; Pyramidal Cells; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Species Specificity; Subcellular Fractions; Synaptic Membranes | 2006 |
Cannabinoid modulation of electrically evoked pH and oxygen transients in the nucleus accumbens of awake rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cerebrovascular Circulation; Electric Stimulation; Energy Metabolism; Hydrogen-Ion Concentration; Male; Medial Forebrain Bundle; Morpholines; Naphthalenes; Nucleus Accumbens; Oxygen Consumption; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2006 |
CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action.
Topics: Acetylcholine; Animals; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Hippocampus; Immunoassay; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microdialysis; Models, Biological; Neurons; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Rimonabant; Vesicular Acetylcholine Transport Proteins | 2006 |
Effects of a cannabinoid agonist on spinal nociceptive neurons in a rodent model of neuropathic pain.
Topics: Analgesics; Animals; Behavior, Animal; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electrophysiology; Hot Temperature; Hyperalgesia; In Vitro Techniques; Morpholines; Naphthalenes; Neurons; Nociceptors; Pain; Peripheral Nervous System Diseases; Piperidines; Posterior Horn Cells; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Cannabinoid CB1 receptor antagonists cause status epilepticus-like activity in the hippocampal neuronal culture model of acquired epilepsy.
Topics: Action Potentials; Animals; Animals, Newborn; Benzoxazines; Cells, Cultured; Disease Models, Animal; Drug Interactions; Epilepsy; Hippocampus; Morpholines; Naphthalenes; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Synaptic Transmission | 2007 |
2-Arachidonylglyceryl ether and abnormal cannabidiol-induced vascular smooth muscle relaxation in rabbit pulmonary arteries via receptor-pertussis toxin sensitive G proteins-ERK1/2 signaling.
Topics: Animals; Animals, Newborn; Cells, Cultured; Dose-Response Relationship, Drug; Flavonoids; Glycerides; In Vitro Techniques; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Pertussis Toxin; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Pulmonary Artery; Pyrazoles; Rabbits; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Resorcinols; Rimonabant; Vasodilation; Vasodilator Agents | 2007 |
Cannabinoid receptor antagonists counteract sensorimotor gating deficits in the phencyclidine model of psychosis.
Topics: Animals; Brain; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Phencyclidine; Piperidines; Psychoses, Substance-Induced; Pyrazoles; Rats; Receptors, Cannabinoid; Reflex, Startle; Rimonabant; Schizophrenia; Sensation Disorders; Synaptic Transmission | 2007 |
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
Topics: Animals; Benzoxazines; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hypothermia; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Cocaine; Conditioning, Operant; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Male; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Reward; Rimonabant; Self Administration | 2008 |
Potentiation of electrical and chemical synaptic transmission mediated by endocannabinoids.
Topics: Analysis of Variance; Animals; Benzoxazines; Cannabinoid Receptor Modulators; Connexins; Cyclic AMP-Dependent Protein Kinases; Dopamine; Electric Stimulation; Endocannabinoids; Eye Proteins; Gap Junctions; Goldfish; Inhibitory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synapses; Synaptic Transmission; Tyrosine 3-Monooxygenase | 2007 |
Determination of endocannabinoid receptor antagonist SR141716 (rimonabant) in plasma by liquid chromatograph tandem mass spectrometry.
Topics: Animals; Area Under Curve; Calibration; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Chemical Fractionation; Chromatography, High Pressure Liquid; Drug Stability; Endocannabinoids; Feasibility Studies; Humans; Piperidines; Pyrazoles; Quality Control; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Reference Standards; Rimonabant; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.
Topics: Animals; Benzoxazines; Bicuculline; Cannabinoids; Cerebellum; Dronabinol; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptic Transmission | 2008 |
Reply to the letter to the editor "Long-term cannabinoid receptor (CB1) blockade in obesity: implications for the development of colorectal cancer".
Topics: Animals; Anti-Inflammatory Agents; Anti-Obesity Agents; Antineoplastic Agents; Carcinoma; Cell Survival; Colorectal Neoplasms; Dose-Response Relationship, Drug; Humans; Mice; Obesity; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2008 |
Cannabinoid-1 receptor antagonists reduce caloric intake by decreasing palatable diet selection in a novel dessert protocol in female rats.
Topics: Animals; Appetite Depressants; Body Weight; Diet; Drug Administration Schedule; Eating; Energy Intake; Female; Food Preferences; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2008 |
Additive subthreshold dose effects of cannabinoid CB(1) receptor antagonist and selective serotonin reuptake inhibitor in antidepressant behavioral tests.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Drug Therapy, Combination; Male; Mice; Mice, Inbred CBA; Models, Animal; Morpholines; Motor Activity; Nomifensine; Piperidines; Pyrazoles; Reboxetine; Receptor, Cannabinoid, CB1; Rimonabant; Selective Serotonin Reuptake Inhibitors; Sertraline; Swimming | 2008 |
Modulation of anxiety by acute blockade and genetic deletion of the CB(1) cannabinoid receptor in mice together with biogenic amine changes in the forebrain.
Topics: Analysis of Variance; Animals; Anxiety; Behavior, Animal; Biogenic Amines; Brain Chemistry; Disease Models, Animal; Dose-Response Relationship, Drug; Exploratory Behavior; Locomotion; Male; Maze Learning; Mice; Mice, Knockout; Piperidines; Prosencephalon; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Statistics as Topic | 2009 |
Cannabinoid receptor 1 signalling dampens activity and mitochondrial transport in networks of enteric neurones.
Topics: Animals; Benzoxazines; Biological Transport; Calcium Signaling; Cannabinoid Receptor Modulators; Cells, Cultured; Enteric Nervous System; Female; Fluorescent Dyes; Guinea Pigs; Male; Mitochondria; Morpholines; Naphthalenes; Neurons; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Rimonabant; Signal Transduction; Synaptic Vesicles | 2009 |
CB1 cannabinoid receptor participates in the vascular hyporeactivity resulting from hemorrhagic shock in rats.
Topics: Animals; Blotting, Western; Gene Expression Regulation; Hypotension; Male; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; Shock, Hemorrhagic; Survival Rate | 2009 |
FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Choice Behavior; Conditioning, Psychological; Dietary Sucrose; Extinction, Psychological; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Species Specificity; Substance Withdrawal Syndrome | 2009 |
Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.
Topics: Analgesics; Arrestins; beta-Arrestins; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line; Cyclohexanols; Humans; Ligands; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Obesity; Phosphorylation; Piperidines; Protein Kinase C; Protein Kinase C beta; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant | 2009 |
Signaling pathways from cannabinoid receptor-1 activation to inhibition of N-methyl-D-aspartic acid mediated calcium influx and neurotoxicity in dorsal root ganglion neurons.
Topics: Animals; Benzoxazines; Calcium; Camphanes; Cell Culture Techniques; Cell Death; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Ganglia, Spinal; Mice; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction | 2009 |
Effect of the CB(1) receptor antagonists rimonabant and AM251 on the firing rate of dorsal raphe nucleus neurons in rat brain slices.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Endocannabinoids; gamma-Aminobutyric Acid; Male; Neurons; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Serotonin | 2009 |
A role for 2-arachidonoylglycerol and endocannabinoid signaling in the locomotor response to novelty induced by olfactory bulbectomy.
Topics: Animals; Arachidonic Acids; Autoradiography; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Cyclohexanols; Densitometry; Dopamine; Endocannabinoids; Environment; Glycerides; Limbic System; Lipid Metabolism; Male; Mass Spectrometry; Motor Activity; Olfactory Bulb; Piperidines; Pyrazoles; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Effects of cannabinoid receptor antagonists on maintenance and reinstatement of methamphetamine self-administration in rhesus monkeys.
Topics: Animals; Cannabinoid Receptor Antagonists; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Female; Macaca mulatta; Male; Methamphetamine; Piperidines; Pyrazoles; Reinforcement, Psychology; Rimonabant; Secondary Prevention; Self Administration | 2010 |
Differential effects of CB(1) neutral antagonists and inverse agonists on gastrointestinal motility in mice.
Topics: Animals; Colon; Epithelium; Feces; Gastrointestinal Motility; Gastrointestinal Transit; Ileum; Immunohistochemistry; Ions; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Permeability; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Water | 2010 |
Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Topics: Agatoxins; Animals; Arachidonic Acids; Benzamides; Benzoxazines; Biophysics; Calcium; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Carbamates; Conotoxins; Dose-Response Relationship, Drug; Down-Regulation; Drug Interactions; Electric Stimulation; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glycerides; Hippocampus; Homeostasis; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Morpholines; Naphthalenes; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Piperidines; Polyamines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Sodium Channel Blockers; Synapses; Tetrodotoxin | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Drug Inverse Agonism; Guinea Pigs; Ileum; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrans; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Endocannabinoid modulation of hyperaemia evoked by physiologically relevant stimuli in the rat primary somatosensory cortex.
Topics: Animals; Arachidonic Acids; Benzoxazines; Bicuculline; Cannabinoid Receptor Modulators; Endocannabinoids; Functional Laterality; Glycerides; Hyperemia; Male; Morpholines; Naphthalenes; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Somatosensory Cortex; Vibrissae | 2010 |
CB1 receptor antagonism impairs the induction of epileptiform activity by group I metabotropic glutamate receptor activation.
Topics: Animals; Dose-Response Relationship, Drug; Epilepsy; Excitatory Postsynaptic Potentials; Methoxyhydroxyphenylglycol; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission | 2010 |
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dronabinol; Dyskinesia, Drug-Induced; Levodopa; Male; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.
Topics: Animals; Benzofurans; Dronabinol; gamma-Aminobutyric Acid; Oocytes; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Recombinant Proteins; Rimonabant; Xenopus | 2012 |
The G protein-coupled cannabinoid-1 (CB1) receptor of mammalian brain: inhibition by phthalate esters in vitro.
Topics: Animals; Benzoxazines; Cyclohexanols; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Mice; Morpholines; Naphthalenes; Phthalic Acids; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, G-Protein-Coupled; Rimonabant | 2011 |
The endocannabinoid 2-arachidonoylglycerol mediates D1 and D2 receptor cooperative enhancement of rat nucleus accumbens core neuron firing.
Topics: Action Potentials; Analysis of Variance; Animals; Dopamine Agents; Drug Interactions; Enzyme Inhibitors; Glycerides; In Vitro Techniques; Male; Neurons; Nucleus Accumbens; Patch-Clamp Techniques; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, Metabotropic Glutamate; Rimonabant; Time Factors; Type C Phospholipases | 2011 |
AM251, cannabinoids receptors ligand, improves recognition memory in rats.
Topics: Animals; Anxiety; Dose-Response Relationship, Drug; Male; Maze Learning; Motor Activity; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Recognition, Psychology; Rimonabant | 2011 |
Tonic regulation of GABAergic synaptic activity on vasopressin neurones by cannabinoids.
Topics: Action Potentials; Animals; Arginine Vasopressin; Calcium; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Egtazic Acid; Female; GABAergic Neurons; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Neurons; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Vasopressins | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Binding, Competitive; Cannabinoid Receptor Agonists; CHO Cells; Cricetinae; Cricetulus; Drug Inverse Agonism; Humans; Kinetics; Mice; Mice, Inbred Strains; Morpholines; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Recombinant Proteins; Rimonabant | 2012 |
Angiotensin II induces vascular endocannabinoid release, which attenuates its vasoconstrictor effect via CB1 cannabinoid receptors.
Topics: Analgesics; Angiotensin II; Animals; Arteries; Benzoxazines; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Mice; Mice, Knockout; Morpholines; Muscle, Skeletal; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Vasoconstriction | 2012 |
Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.
Topics: Animals; Dronabinol; Male; Mice; Mice, Knockout; Motor Activity; Neurons; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ventral Tegmental Area | 2013 |
The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.
Topics: Animals; Anti-Anxiety Agents; Bromodeoxyuridine; Camphanes; Cannabidiol; Cannabinoid Receptor Antagonists; Cell Cycle; Cell Line, Transformed; Cell Proliferation; Disease Models, Animal; Feeding Behavior; Glial Fibrillary Acidic Protein; Hippocampus; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neurogenesis; Piperidines; Pyrazoles; Rimonabant; Stress, Psychological; Thymidine Kinase | 2013 |
Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Cyclohexanols; Dose-Response Relationship, Drug; Endocannabinoids; Male; Phencyclidine; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Quinazolinones; Rats; Receptor, Cannabinoid, CB1; Receptor, Cholecystokinin B; Rimonabant; Schizophrenia; Social Behavior | 2013 |
Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Partial Agonism; Lithium Chloride; Male; Nausea; Phytochemicals; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Endocannabinoids promote cocaine-induced impulsivity and its rapid dopaminergic correlates.
Topics: Animals; Cannabinoid Receptor Antagonists; Cocaine; Conditioning, Operant; Cues; Dopamine; Dopaminergic Neurons; Endocannabinoids; Impulsive Behavior; Male; Motor Activity; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Time Factors | 2014 |
Spinal neuronal cannabinoid receptors mediate urodynamic effects of systemic fatty acid amide hydrolase (FAAH) inhibition in rats.
Topics: Amidohydrolases; Animals; Camphanes; Male; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Spinal Cord; Urinary Bladder Neck Obstruction; Urodynamics | 2016 |
Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium; Calcium Channels; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Ependymoglial Cells; Glycerides; Indoles; Male; Membrane Potentials; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2016 |
Encapsulation of cannabinoid drugs in nanostructured lipid carriers.
Topics: Benzamides; Cannabinoids; Carbamates; Drug Carriers; Lipids; Nanostructures; Piperidines; Pyrazoles; Rimonabant | 2016 |
Genetic or pharmacological depletion of cannabinoid CB1 receptor protects against dopaminergic neurotoxicity induced by methamphetamine in mice.
Topics: Animals; Apoptosis; Butadienes; Cells, Cultured; Corpus Striatum; Dopamine; Extracellular Signal-Regulated MAP Kinases; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurotoxicity Syndromes; Nitriles; Oxidative Stress; Piperidines; Protein Kinase C-delta; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Rimonabant; Sulpiride | 2017 |
Cannabinoids Regulate the Diameter of Pericyte-Containing Retinal Capillaries in Rats.
Topics: Animals; Arachidonic Acids; Blotting, Western; Camphanes; Cannabinoid Receptor Antagonists; Cannabinoids; Capillaries; Endocannabinoids; Guanylate Cyclase; Immunohistochemistry; Male; Nitric Oxide Synthase; Pericytes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Cannabinoid; Retina; Rimonabant | 2017 |
Acute Ethanol Inhibition of Adult Hippocampal Neurogenesis Involves CB1 Cannabinoid Receptor Signaling.
Topics: Animals; Binge Drinking; Cannabinoids; Carbamates; Caspase 3; Cell Death; Cell Proliferation; Doublecortin Domain Proteins; Doublecortin Protein; Drug Interactions; Endocannabinoids; Ethanol; Hippocampus; Ki-67 Antigen; Male; Microtubule-Associated Proteins; Neurogenesis; Neuropeptides; Piperazines; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant | 2018 |
The cannabinoid ligands SR141716A and AM251 enhance human and mouse islet function via GPR55-independent signalling.
Topics: Animals; Cannabinoids; Cell Proliferation; Endocannabinoids; Female; Humans; Insulin; Insulin Secretion; Insulin-Secreting Cells; Islets of Langerhans; Ligands; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Signal Transduction | 2020 |