am 251 and morphine
am 251 has been researched along with morphine in 28 studies
Research
Studies (28)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (42.86) | 29.6817 |
| 2010's | 13 (46.43) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Bánki, L; Deli, MA; Dvorácskó, S; Horváth, G; Kékesi, G; Keresztes, A; Macedonio, G; Mollica, A; Pieretti, S; Stefanucci, A; Tömböly, C; Tuboly, G; Walter, FR; Zádor, F | 1 |
| Hamza, MS; Makriyannis, A; Malan, TP; Mata, HP; Porreca, F; Siegel, EM; Simoneau, II; Vanderah, TW | 1 |
| Dehpour, AR; Hajrasouliha, AR; Homayoun, H; Moezi, L; Sadeghipour, H; Samini, M; Shafaroodi, H; Tavakoli, S | 1 |
| Fazli-Tabaei, S; Kangarlu-Haghighi, K; Khalilzadeh, A; Zarrindast, MR | 1 |
| Chabot, JG; Jhamandas, K; Ma, W; Quirion, R; Trang, T | 1 |
| McMahon, LR | 1 |
| Jhamandas, K; Sutak, M; Trang, T | 1 |
| Ahmadi, S; Nouri, M; Zarrindast, MR | 1 |
| da Fonseca Pacheco, CM; da Fonseca Pacheco, D; de Castro Perez, A; de Francischi, JN; Duarte, ID; Klein, A | 1 |
| Azizi, P; Haghparast, A; Hassanpour-Ezatti, M | 1 |
| de Francischi, JN; Duarte, ID; Klein, A; Pacheco, CM; Pacheco, Dda F; Perez, AC; Reis, GM | 1 |
| Allen, CP; Lang, ST; Leri, F; Manwell, LA; Parker, LA; Satvat, E | 1 |
| Azizi, P; Haghparast, A; Hassanpour-Ezatti, M; Khorrami, H; Naderi, N | 1 |
| Nayer-Nouri, T; Rezayof, A; Sardari, M; Zarrindast, MR | 1 |
| Keresztes, A; Largent-Milnes, TM; Ren, J; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV | 1 |
| Haghparast, A; Pahlevani, P; Rashidy-Pour, A; Shaigani, P; Vafaei, AA; Vaziri, A; Zarepour, L | 1 |
| Altun, A; Bagcivan, I; Durmus, N; Gursoy, S; Ozdemir, E; Yildirim, K | 1 |
| Haghparast, A; Khaleghzadeh-Ahangar, H | 2 |
| Ahmad, T; Laviolette, SR; Lyons, D; Sun, N | 1 |
| Ghasemzadeh, Z; Ofogh, SN; Rezayof, A; Sardari, M | 1 |
| Cai, X; Chen, B; He, J; Li, S; Wang, N; Wang, Y; Wei, S; Zhang, H; Zhang, J | 1 |
| Gao, G; Heng, L; Jia, D; Qu, L; Song, J; Wang, X; Wang, Y; Zhang, H | 1 |
| Wang, F; Wu, L; Yao, L; Zhang, H; Zhao, X | 1 |
| Haghparast, A; Khaleghzadeh-Ahangar, H; Khodagholi, F; Shaerzadeh, F | 1 |
| Hohmann, AG; Iyer, V; Makriyannis, A; Saberi, SA; Slivicki, RA; Vemuri, VK | 1 |
| Bortolanza, M; Crivelaro do Nascimento, G; Del Bel, EA; Ferrari, DP; Ferreira-Junior, NC; Guimaraes, FS | 1 |
| Fichna, J; Polepally, PR; Świerczyński, M; Szymaszkiewicz, A; Talar, M; Zielińska, M; Zjawiony, JK | 1 |
Other Studies
28 other study(ies) available for am 251 and morphine
| Article | Year |
|---|---|
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalins; Indoles; Mice; Molecular Structure; Naphthalenes; Oxycodone; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Structure-Activity Relationship | 2019 |
The cannabinoid agonist WIN55,212-2 suppresses opioid-induced emesis in ferrets.
Topics: Analgesics, Opioid; Animals; Antiemetics; Benzoxazines; Ferrets; Male; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Vomiting | 2001 |
The interaction of cannabinoids and opioids on pentylenetetrazole-induced seizure threshold in mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Differential Threshold; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Mice, Inbred Strains; Morphine; Naltrexone; Narcotic Antagonists; Narcotics; Pentylenetetrazole; Piperidines; Pyrazoles; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Opioid; Seizures; Statistics, Nonparametric; Time Factors | 2004 |
Influence of intracerebroventricular administration of cannabinergic drugs on morphine state-dependent memory in the step-down passive avoidance test.
Topics: Analgesics, Opioid; Animals; Avoidance Learning; Benzoxazines; Injections, Intraventricular; Male; Memory; Mice; Morphine; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2006 |
Spinal modulation of calcitonin gene-related peptide by endocannabinoids in the development of opioid physical dependence.
Topics: Animals; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Cannabinoids; Capsaicin; Drug Administration Schedule; Endocannabinoids; Ganglia, Spinal; Hot Temperature; Immunologic Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Neurons; Nociceptors; Opioid-Related Disorders; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; RNA, Messenger; Spinal Cord; Substance Withdrawal Syndrome | 2006 |
Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Ketamine; Macaca mulatta; Male; Midazolam; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2006 |
Involvement of cannabinoid (CB1)-receptors in the development and maintenance of opioid tolerance.
Topics: Analgesics, Opioid; Animals; Cells, Cultured; Data Interpretation, Statistical; Dose-Response Relationship, Drug; Drug Tolerance; Ganglia, Spinal; Injections, Spinal; Male; Morphine; Nociceptors; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Calcitonin Gene-Related Peptide | 2007 |
Cannabinoid CB1 receptors of the dorsal hippocampus are important for induction of conditioned place preference (CPP) but do not change morphine CPP.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Calcium Channel Blockers; Conditioning, Operant; Dose-Response Relationship, Drug; Hippocampus; Male; Microinjections; Morphine; Morpholines; Motor Activity; Naloxone; Naphthalenes; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2007 |
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Benzomorphans; Cannabinoid Receptor Modulators; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Indoles; Male; Morphine; Organophosphonates; Pain; Pain Measurement; Piperazines; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2008 |
Effects of CB1 receptor antagonist within the nucleus accumbens on the acquisition and expression of morphine-induced conditioned place preference in morphine-sensitized rats.
Topics: Analysis of Variance; Animals; Association Learning; Behavior, Animal; Cannabinoid Receptor Modulators; Conditioning, Classical; Dose-Response Relationship, Drug; Male; Microinjections; Morphine; Narcotics; Nucleus Accumbens; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Statistics, Nonparametric | 2009 |
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
Topics: Analgesics, Opioid; Animals; Indoles; Male; Mice; Morphine; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu | 2009 |
FAAH inhibitor, URB-597, promotes extinction and CB(1) antagonist, SR141716, inhibits extinction of conditioned aversion produced by naloxone-precipitated morphine withdrawal, but not extinction of conditioned preference produced by morphine in rats.
Topics: Amidohydrolases; Animals; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Choice Behavior; Conditioning, Psychological; Dietary Sucrose; Extinction, Psychological; Female; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Morphine; Morphine Dependence; Naloxone; Narcotic Antagonists; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant; Species Specificity; Substance Withdrawal Syndrome | 2009 |
Sub-chronic administration of AM251, CB1 receptor antagonist, within the nucleus accumbens induced sensitization to morphine in the rat.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Catheterization; Conditioning, Classical; Dose-Response Relationship, Drug; Locomotion; Morphine; Nucleus Accumbens; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Space Perception; Time Factors | 2009 |
Functional interaction between morphine and central amygdala cannabinoid CB1 receptors in the acquisition and expression of conditioned place preference.
Topics: Amygdala; Analysis of Variance; Animals; Arachidonic Acids; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Male; Morphine; Motor Activity; Narcotics; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule | 2011 |
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoids; Hyperalgesia; Indoles; Inflammation; Interleukin-1beta; Male; Morphine; Neuroglia; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Spinal Cord; Tumor Necrosis Factor-alpha | 2012 |
Involvement of CB1 receptors in the ventral tegmental area in the potentiation of morphine rewarding properties in acquisition but not expression in the conditioned place preference model.
Topics: Analgesics, Opioid; Animals; Association Learning; Benzoxazines; Conditioning, Operant; Male; Morphine; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Ventral Tegmental Area | 2013 |
Attenuation of morphine antinociceptive tolerance by cannabinoid CB1 and CB2 receptor antagonists.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dioxoles; Dose-Response Relationship, Drug; Drug Tolerance; Male; Morphine; Nociception; Pain Threshold; Piperidines; Pyrazoles; Quinolones; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2015 |
Intra-accumbal CB1 receptor blockade reduced extinction and reinstatement of morphine.
Topics: Analysis of Variance; Animals; Conditioning, Operant; Dose-Response Relationship, Drug; Extinction, Psychological; Male; Morphine; Narcotics; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reward; Time Factors | 2015 |
Bi-directional cannabinoid signalling in the basolateral amygdala controls rewarding and aversive emotional processing via functional regulation of the nucleus accumbens.
Topics: Analgesics, Opioid; Animals; Basolateral Nuclear Complex; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Conditioning, Classical; Dopamine Antagonists; Flupenthixol; Male; Morphine; Morpholines; Motivation; Naphthalenes; Neural Pathways; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, N-Methyl-D-Aspartate; Reward; Signal Transduction | 2017 |
Basolateral amygdala CB1 cannabinoid receptors are involved in cross state-dependent memory retrieval between morphine and ethanol.
Topics: Animals; Basolateral Nuclear Complex; Benzoxazines; Ethanol; Male; Memory; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2016 |
Blockade of Cannabinoid CB1 receptor attenuates the acquisition of morphine-induced conditioned place preference along with a downregulation of ERK, CREB phosphorylation, and BDNF expression in the nucleus accumbens and hippocampus.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cannabinoid Receptor Antagonists; Conditioning, Classical; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Hippocampus; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 3; Morphine; Nucleus Accumbens; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward | 2016 |
Enhanced ability of TRPV1 channels in regulating glutamatergic transmission after repeated morphine exposure in the nucleus accumbens of rat.
Topics: Animals; Capsaicin; Corpus Striatum; Excitatory Postsynaptic Potentials; Glutamic Acid; Male; Morphine; Narcotics; Neuronal Plasticity; Neurotransmitter Agents; Nucleus Accumbens; Piperidines; Presynaptic Terminals; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome; Synaptic Transmission; Tissue Culture Techniques; TRPV Cation Channels | 2017 |
Cannabinoid 1 receptor blockade in the dorsal hippocampus prevents the reinstatement but not acquisition of morphine-induced conditioned place preference in rats.
Topics: Animals; Blotting, Western; Cannabinoid Receptor Antagonists; Cerebral Cortex; Conditioning, Psychological; Extinction, Psychological; Gene Expression; Hippocampus; Male; Microinjections; Morphine; Narcotics; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Space Perception; Spatial Behavior | 2017 |
Modulatory role of the intra-accumbal CB1 receptor in protein level of the c-fos and pCREB/CREB ratio in the nucleus accumbens and ventral tegmental area in extinction and morphine seeking in the rats.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Drug-Seeking Behavior; Extinction, Psychological; Male; Morphine; Morphine Dependence; Morpholines; Naphthalenes; Narcotics; Nucleus Accumbens; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Ventral Tegmental Area | 2018 |
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit.
Topics: Amidohydrolases; Analgesics, Opioid; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Brain; Cannabinoids; Carbamates; Gastrointestinal Transit; Hyperalgesia; Indoles; Mice; Mice, Inbred C57BL; Morphine; Morpholines; Neuralgia; Nociception; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2018 |
Cannabinoid receptor modulation changes the accumbal neuronal responses to morphine in the reinstatement of morphine-induced conditioned place preference.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Conditioning, Classical; Drug-Seeking Behavior; Male; Morphine; Morpholines; Naphthalenes; Narcotics; Neurons; Nucleus Accumbens; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2020 |
Cannabidiol increases the nociceptive threshold in a preclinical model of Parkinson's disease.
Topics: Amidohydrolases; Analgesics; Animals; Benzamides; Brain; Cannabidiol; Capsaicin; Carbamates; Celecoxib; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; Morphine; Nociception; Oxidopamine; Pain; Parkinson Disease; Piperidines; Pyrazoles; Thienamycins | 2020 |
Critical interactions between opioid and cannabinoid receptors during tolerance and physical dependence development to opioids in the murine gastrointestinal tract: proof of concept.
Topics: Analgesics, Opioid; Animals; Cannabinoids; Diterpenes, Clerodane; Drug Tolerance; Ileum; Male; Mice; Mice, Inbred BALB C; Morphine; Muscle, Smooth; Naloxone; Piperidines; Pyrazoles; Receptors, Cannabinoid; Substance Withdrawal Syndrome | 2021 |