am 251 and dronabinol
am 251 has been researched along with dronabinol in 91 studies
Research
Studies (91)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (3.30) | 18.2507 |
| 2000's | 49 (53.85) | 29.6817 |
| 2010's | 38 (41.76) | 24.3611 |
| 2020's | 1 (1.10) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Drmota, T; Elebring, T; Greasley, PJ; Hermansson, NO; Hjorth, S; Larsson, N; Leonova, J; Nilsson, K; Ryberg, E; Sjögren, S | 1 |
| Bradshaw, HB; Dunn, E; McHugh, D; Page, J | 1 |
| Bánki, L; Deli, MA; Dvorácskó, S; Horváth, G; Kékesi, G; Keresztes, A; Macedonio, G; Mollica, A; Pieretti, S; Stefanucci, A; Tömböly, C; Tuboly, G; Walter, FR; Zádor, F | 1 |
| Gatley, SJ; Gifford, AN; Lan, R; Makriyannis, A; Volkow, ND | 1 |
| Andrenyak, DM; Deng, H; Dey, SK; Ma, W; Makriyannis, A; Moody, DE; Paria, BC; Schmid, HH; Schmid, PC | 1 |
| Díaz-Laviada, I; Miguel, A; Ruiz, L | 1 |
| Díaz-Laviada, I; Ruiz, L; Sánchez, MG; Velasco, L | 1 |
| Brune, K; Hinz, B; Pahl, A; Ramer, R | 1 |
| Kato, H; Kurihara, J; Nakane, S; Nishigaki, M; Okubo, Y; Sugiura, T; Suzuki, S; Takata, Y; Waku, K | 1 |
| Boland, B; Campbell, V; Downer, E; Fogarty, M | 1 |
| Dubinett, SM; Gardner, B; Liu, Q; Makriyannis, A; Sharma, S; Tashkin, DP; Zu, LX | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; March, JE | 1 |
| Ates, M; Gühring, H; Hamza, M; Seidel, K | 1 |
| Brotchie, JM; Brown, TM; Fitzjohn, SM | 1 |
| Engler, C; Feuerstein, TJ; Steffens, M; Zentner, J | 1 |
| Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA | 1 |
| Inoue, A; Kawamoto, M; Nakata, Y; Oshita, K; Tang, HB; Yuge, O | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 1 |
| Nomikos, GG; Panagis, G; Vlachou, S | 1 |
| Gorzalka, BB; Hill, MN | 1 |
| Nomikos, GG; Tzavara, ET; Witkin, JM | 1 |
| Brown, CM; Lu, D; Makriyannis, A; McLaughlin, PJ; Salamone, JD; Thakur, G; Winston, KM | 1 |
| Järbe, TU; Liu, Q; Makriyannis, A | 1 |
| Floresco, SB; Froese, LM; Hill, MN; Morrish, AC; Sun, JC | 1 |
| Fowler, CJ; Jacobsson, SO; Nilsson, O | 1 |
| McMahon, LR | 2 |
| Jarrett, MM; Parker, LA; Scantlebury, J | 1 |
| Gardiner, SM; O'Sullivan, SE; Randall, MD | 1 |
| Braida, D; Castiglioni, C; Guidali, C; Limonta, V; Parolaro, D; Realini, N; Rubino, T; Sala, M; Viganò, D | 1 |
| Chocyk, A; Maćkowiak, M; Markowicz-Kula, K; Wedzony, K | 1 |
| Koek, W; McMahon, LR | 1 |
| Brown, C; Fan, P; Makriyannis, A; McLaughlin, PJ; Olszewska, T; Olzewska, T; Pang, Y; Parker, LA; Peng, Y; Salamone, JD; Sink, KS; Thakur, GA; Vemuri, VK; Wood, JA | 1 |
| Mitchell, VA; Vaughan, CW; Vuong, LA | 1 |
| Boctor, SY; France, CP; Koek, W; Martinez, JL | 1 |
| Araya, KA; David Pessoa Mahana, C; González, LG | 1 |
| Guidali, C; Massi, P; Parolaro, D; Realini, N; Rubino, T; Valenti, M; Vigano, D | 1 |
| Gorzalka, BB; Hill, MN; McLaughlin, RJ; Morrish, AC | 1 |
| Kendall, DA; Ralevic, V; Wilkinson, JD | 1 |
| Pertwee, RG | 1 |
| Ma, YL; Stephens, GJ; Weston, SE; Whalley, BJ | 1 |
| Araújo, JR; Azevedo, I; Gonçalves, P; Martel, F | 1 |
| Ballesteros, I; Chancellor, MB; Coyle, CH; de Miguel, F; Hayn, MH; Tyagi, P; Tyagi, S; Yoshimura, N | 1 |
| Dennis, I; Stephens, GJ; Whalley, BJ | 1 |
| Fujino, H; Hirabayashi, T; Kaneko, M; Mashimo, M; Murayama, T; Nabemoto, M; Nakamura, H; Okuma, Y; Saito, T; Someya, A; Yamaguchi, N | 1 |
| Gustafsson, SB; Jacobsson, SO; Jonsson, M; Lindgren, T | 1 |
| Bernardi, G; Centonze, D; De Chiara, V; Kusayanagi, H; Mataluni, G; Musella, A; Rossi, S; Usiello, A | 1 |
| Chocyk, A; Dudys, D; Maćkowiak, M; Wedzony, K | 1 |
| Araújo, JR; Gonçalves, P; Martel, F | 1 |
| Izenwasser, S; Reed, SC; Wade, D; Werling, LL | 1 |
| Fadda, P; McKillop-Smith, S; Pertwee, RG; Platt, B; Riedel, G; Robinson, L | 1 |
| Gorzalka, BB; Hill, MN; Morrish, AC; Riebe, CJ | 1 |
| Challapalli, SC; Smith, PJ; Zhang, F | 1 |
| Floresco, SB; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Morrish, AC; Viau, V | 1 |
| Bernardi, G; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Errico, F; Mataluni, G; Musella, A; Rossi, S; Sacchetti, L; Siracusano, A; Usiello, A | 1 |
| Chai, SY; Chen, CJ; Li, YN; Li, YY; Lv, S; Ni, JB; Storr, M; Wu, RH; Yüce, B | 1 |
| Hoffman, AF; Kawamura, M; Laaris, N; Lupica, CR; Masino, SA | 1 |
| Gorzalka, BB; Hill, MN; Lee, TT; Riebe, CJ | 1 |
| Touriño, C; Valverde, O; Zimmer, A | 1 |
| Bagni, C; Bari, M; Bernardi, G; Centonze, D; De Chiara, V; Maccarrone, M; Musella, A; Rapino, C; Rossi, S | 1 |
| Dodd, GT; Luckman, SM; Lutz, B; Mancini, G | 1 |
| Angelucci, F; Bernardi, G; Caltagirone, C; Cantarella, C; Castelli, M; Cavasinni, F; Centonze, D; De Chiara, V; Maccarrone, M; Mataluni, G; Musella, A; Napolitano, F; Rossi, S; Sacchetti, L; Usiello, A | 1 |
| Makwana, R; Molleman, A; Parsons, ME | 1 |
| Hébert, TE; Hudson, BD; Kelly, ME | 1 |
| Alhamoruni, A; Larvin, M; Lee, AC; O'Sullivan, SE; Wright, KL | 1 |
| Dowd, E; Finn, DP; Gorman, AM; Walsh, S | 1 |
| Baur, R; Gertsch, J; Sigel, E | 1 |
| Candeletti, S; Cannarsa, R; Carretta, D; Lattanzio, F; Romualdi, P | 1 |
| Raffa, RB; Ward, SJ | 1 |
| Järbe, TU; LeMay, BJ; Makriyannis, A; Nikas, SP; Shukla, VG; Tai, S; Zvonok, A | 1 |
| Caron, MG; Daigle, TL; Wetsel, WC | 1 |
| Armida, M; Beggiato, S; Chiodi, V; Domenici, MR; Ferrante, A; Ferraro, L; Martire, A; Popoli, P; Potenza, RL; Tanganelli, S; Uchigashima, M; Watanabe, M | 1 |
| Baxter, P; Benfenati, F; Cerovic, M; Greco, B; Nazzaro, C; Parolaro, D; Pedarzani, P; Rubino, T; Tkatch, T; Tonini, R; Trusel, M | 1 |
| Limebeer, CL; Mechoulam, R; Parker, LA; Rock, EM | 1 |
| Bartsch, D; Bénard, G; Chaouloff, F; Dubreucq, S; Durand, A; Georges, F; Glangetas, C; Groc, L; Marsicano, G; Massa, F; Matias, I; Richard, E; Soria-Gomez, E; Wadleigh, A | 1 |
| Cao, MH; Chen, CJ; Feng, YJ; Han, T; Li, K; Li, YY; Lin, XH; Xu, J | 1 |
| Akhtar, MT; Ali, S; Rashidi, H; Richardson, MK; van der Kooy, F; Verpoorte, R | 1 |
| Duncan, M; Parker, LA; Rock, EM; Sticht, MA; Stott, C | 1 |
| Keller, A; Raver, SM | 1 |
| Bouchard, C; Ducrot, C; Fortier, E; Gallo, A; Rompré, PP | 1 |
| Fišar, Z; Hroudová, J; Singh, N | 1 |
| Di Marzo, V; Ligresti, A; Melis, M; Parolaro, D; Piscitelli, F; Prini, P; Rubino, T; Sagheddu, C; Tonini, R; Trusel, M; Zamberletti, E | 1 |
| Calik, MW; Carley, DW | 2 |
| Bagüés, A; Martín, MI; Sánchez-Robles, EM | 1 |
| Marti, M; Ossato, A; Rimondo, C; Seri, C; Serpelloni, G; Trapella, C; Vigolo, A | 1 |
| Bing, YH; Chu, CP; Qiu, DL; Wu, MC | 1 |
| Borea, PA; Canazza, I; De Luca, MA; Di Rosa, F; Fantinati, A; Gregori, A; Margiani, G; Marti, M; Ossato, A; Rimondo, C; Serpelloni, G; Trapella, C; Varani, K; Vincenzi, F | 1 |
| Aritake, K; Cherasse, Y; Kaushik, MK; Kikura-Hanajiri, R; Malyshevskaya, O; Uchiyama, N; Urade, Y | 1 |
| Allman, BL; Desai, SJ; Jobson, CEL; Laviolette, SR; Norris, C; Pereira, B; Rajakumar, N; Renard, J; Szkudlarek, HJ | 1 |
| Dahlén, A; Guo, S; Melgoza, A; Wagle, M; Zarei, M | 1 |
Reviews
3 review(s) available for am 251 and dronabinol
| Article | Year |
|---|---|
A role for cannabinoid CB1 receptors in mood and anxiety disorders.
Topics: Affect; Animals; Anxiety Disorders; Cannabinoid Receptor Modulators; Dronabinol; Humans; Models, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2005 |
GPR55: a new member of the cannabinoid receptor clan?
Topics: Amides; Animals; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Ethanolamines; Humans; Oleic Acids; Palmitic Acids; Piperidines; Pyrazoles; Receptors, Cannabinoid; Receptors, G-Protein-Coupled | 2007 |
CB₁-independent mechanisms of Δ⁹-THCV, AM251 and SR141716 (rimonabant).
Topics: Animals; Anti-Obesity Agents; Appetite Depressants; Dronabinol; Humans; Ligands; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu; Rimonabant | 2012 |
Other Studies
88 other study(ies) available for am 251 and dronabinol
| Article | Year |
|---|---|
The orphan receptor GPR55 is a novel cannabinoid receptor.
Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Cannabidiol; Cannabinoids; Cell Line; Cloning, Molecular; Cyclohexanols; Down-Regulation; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mice; Molecular Sequence Data; Organ Specificity; Polymerase Chain Reaction; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Structure-Activity Relationship | 2007 |
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Topics: Arachidonic Acids; Cell Line, Tumor; Cell Movement; Dronabinol; Endometrium; Female; Glycine; HEK293 Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, G-Protein-Coupled; RNA, Messenger; Transfection | 2012 |
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalins; Indoles; Mice; Molecular Structure; Naphthalenes; Oxycodone; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Structure-Activity Relationship | 2019 |
123I-labeled AM251: a radioiodinated ligand which binds in vivo to mouse brain cannabinoid CB1 receptors.
Topics: Animals; Brain; Cell Membrane; Chromatography, High Pressure Liquid; Dronabinol; Hippocampus; Iodine Radioisotopes; Isotope Labeling; Male; Mice; Mice, Inbred Strains; Motor Activity; Piperidines; Protein Binding; Pyrazoles; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tissue Distribution | 1996 |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism.
Topics: Annexin A5; Apoptosis; Benzoxazines; DNA Fragmentation; Dronabinol; Fluorescent Antibody Technique; Humans; Indoles; Male; Mitochondria; Morpholines; Naphthalenes; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Sphingosine; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1999 |
delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1.
Topics: Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Humans; Immunoblotting; Male; Nerve Growth Factor; Pertussis Toxin; Piperidines; Prostatic Neoplasms; Protein Binding; Proto-Oncogene Proteins c-raf; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Endocannabinoids; Glycerides; Male; Myocardium; Neurotransmitter Agents; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sympathetic Nervous System | 2001 |
Delta 9-tetrahydrocannabinol induces the apoptotic pathway in cultured cortical neurones via activation of the CB1 receptor.
Topics: Animals; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Cytochrome c Group; DNA Fragmentation; Dronabinol; Hallucinogens; Neurons; Piperidines; Poly(ADP-ribose) Polymerases; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Autocrine and paracrine regulation of lymphocyte CB2 receptor expression by TGF-beta.
Topics: 1-Methyl-3-isobutylxanthine; Autocrine Communication; Blotting, Northern; Blotting, Western; Camphanes; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Down-Regulation; Dronabinol; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; GTP-Binding Proteins; Humans; Immunoenzyme Techniques; Lymphocytes; Models, Biological; Paracrine Communication; Piperidines; Psychotropic Drugs; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; RNA; Transforming Growth Factor beta; Up-Regulation; Virulence Factors, Bordetella | 2002 |
Influence of the CB(1) receptor antagonist, AM 251, on the regional haemodynamic effects of WIN-55212-2 or HU 210 in conscious rats.
Topics: Adrenergic beta-Antagonists; Animals; Benzoxazines; Cannabinoids; Cardiovascular System; Dronabinol; Drug Interactions; Hemodynamics; Male; Morpholines; Naphthalenes; Piperidines; Propanolamines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 2002 |
Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Capsaicin; Cyclooxygenase Inhibitors; Dinoprostone; Dronabinol; Endocannabinoids; Fatty Acids, Unsaturated; Flurbiprofen; Immunoassay; In Vitro Techniques; Phospholipases A; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Spinal Cord | 2003 |
Cannabinoids decrease corticostriatal synaptic transmission via an effect on glutamate uptake.
Topics: Amino Acids; Animals; Cannabinoids; Cerebral Cortex; Corpus Striatum; Dronabinol; Glutamic Acid; In Vitro Techniques; Male; Neural Inhibition; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Metabotropic Glutamate; Rimonabant; Synaptic Transmission; Xanthenes | 2003 |
Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex.
Topics: Adenylyl Cyclases; Amygdala; Animals; Arachidonic Acids; Benzoxazines; Binding Sites; Colforsin; Cyclic AMP; Cyclohexanols; Dopamine; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Humans; Ligands; Male; Morpholines; Naphthalenes; Neocortex; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Synaptosomes; Tetrodotoxin; Tritium | 2004 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
CB(1) cannabinoid receptor stimulation modulates transient receptor potential vanilloid receptor 1 activities in calcium influx and substance P Release in cultured rat dorsal root ganglion cells.
Topics: Animals; Bradykinin; Calcium; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Capsaicin; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase 2; Dose-Response Relationship, Drug; Dronabinol; Enzyme Induction; Enzyme Inhibitors; Ganglia, Spinal; Isoquinolines; Male; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Substance P; Sulfonamides; Time Factors | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
CB1 cannabinoid receptor agonists increase intracranial self-stimulation thresholds in the rat.
Topics: Animals; Benzoxazines; Brain; Dronabinol; Electrodes, Implanted; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reward; Rimonabant; Self Stimulation | 2005 |
Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test.
Topics: Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arachidonic Acids; Desipramine; Dose-Response Relationship, Drug; Dronabinol; Male; Motor Activity; Oleic Acids; Piperidines; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Swimming | 2005 |
The novel cannabinoid agonist AM 411 produces a biphasic effect on accuracy in a visual target detection task in rats.
Topics: Adamantane; Animals; Dose-Response Relationship, Drug; Dronabinol; Mice; Muscarinic Antagonists; Pattern Recognition, Visual; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Scopolamine; Task Performance and Analysis | 2005 |
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Topics: Animals; Arachidonic Acids; Camphanes; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism | 2006 |
Alterations in behavioral flexibility by cannabinoid CB1 receptor agonists and antagonists.
Topics: Animals; Appetitive Behavior; Attention; Cues; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Habituation, Psychophysiologic; Injections, Intraperitoneal; Maze Learning; Motivation; Orientation; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Reversal Learning | 2006 |
The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
Topics: Analysis of Variance; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cell Movement; Chemotaxis; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Flow Cytometry; Humans; Indoles; Interleukin-8; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Thapsigargin; Tumor Necrosis Factor-alpha | 2006 |
Characterization of cannabinoid agonists and apparent pA2 analysis of cannabinoid antagonists in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Analgesics, Opioid; Anesthetics, Dissociative; Anesthetics, Intravenous; Anesthetics, Local; Animals; Benzoxazines; Camphanes; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cocaine; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Hallucinogens; Ketamine; Macaca mulatta; Male; Midazolam; Morphine; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2006 |
Discriminative stimulus effects of the cannabinoid CB1 antagonist SR 141716A in rhesus monkeys pretreated with Delta9-tetrahydrocannabinol.
Topics: Animals; Benzoxazines; Cannabinoids; Conditioning, Operant; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Female; Hallucinogens; Humans; Injections, Intravenous; Injections, Subcutaneous; Ketamine; Macaca mulatta; Male; Midazolam; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2006 |
Effect of delta9-tetrahydrocannabinol on quinine palatability and AM251 on sucrose and quinine palatability using the taste reactivity test.
Topics: Animals; Avoidance Learning; Cannabinoid Receptor Agonists; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Food Preferences; Male; Piperidines; Psychotropic Drugs; Pyrazoles; Quinine; Rats; Receptors, Cannabinoid; Single-Blind Method; Sucrose; Taste | 2007 |
The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase.
Topics: Animals; Blood Pressure; Dronabinol; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Vasodilation | 2007 |
Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats.
Topics: Adenosine Triphosphate; Aminoacetonitrile; Analysis of Variance; Animals; Behavior, Animal; Brain; Brain Chemistry; Calcium-Calmodulin-Dependent Protein Kinase Type 2; CREB-Binding Protein; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Male; Maze Learning; Motor Activity; Piperidines; Proto-Oncogene Proteins c-fos; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley | 2007 |
Acute activation of CB1 cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the rat hippocampus.
Topics: Animals; Cannabinoids; Cell Count; Cell Differentiation; Cell Proliferation; Dentate Gyrus; Dose-Response Relationship, Drug; Doublecortin Domain Proteins; Doublecortin Protein; Down-Regulation; Dronabinol; Excitatory Amino Acid Antagonists; Immunohistochemistry; Ki-67 Antigen; Male; Memory Disorders; Microtubule-Associated Proteins; Neural Cell Adhesion Molecule L1; Neuronal Plasticity; Neurons; Neuropeptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sialic Acids; Stem Cells; Time Factors | 2007 |
Differences in the relative potency of SR 141716A and AM 251 as antagonists of various in vivo effects of cannabinoid agonists in C57BL/6J mice.
Topics: Animals; Benzoxazines; Cannabinoids; Catalepsy; Dose-Response Relationship, Drug; Dronabinol; Hypothermia; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Morpholines; Motor Activity; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors | 2007 |
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats.
Topics: Adamantane; Analysis of Variance; Animals; Behavior, Animal; Conditioning, Operant; Cyclic AMP; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Eating; Male; Motor Activity; Nausea; Piperidines; Protein Binding; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement, Psychology | 2008 |
Actions of N-arachidonyl-glycine in a rat neuropathic pain model.
Topics: Analgesics; Animals; Arachidonic Acids; Area Under Curve; Camphanes; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Glycine; Hyperalgesia; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Sciatica | 2008 |
The cannabinoid CB1 receptor antagonist AM251 does not modify methamphetamine reinstatement of responding.
Topics: Animals; Body Temperature; Central Nervous System Stimulants; Dose-Response Relationship, Drug; Dronabinol; Infusions, Intravenous; Injections, Intraperitoneal; Male; Methamphetamine; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Self Administration; Time Factors | 2007 |
Role of cannabinoid CB1 receptors and Gi/o protein activation in the modulation of synaptosomal Na+,K+-ATPase activity by WIN55,212-2 and delta(9)-THC.
Topics: Animals; Benzoxazines; Brain; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Enzyme Inhibitors; Female; GTP-Binding Protein alpha Subunits, Gi-Go; In Vitro Techniques; Mice; Morpholines; Naloxone; Naphthalenes; Narcotic Antagonists; Ouabain; Pertussis Toxin; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Sodium-Potassium-Exchanging ATPase; Synaptosomes | 2007 |
CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour.
Topics: Amygdala; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Anxiety; Behavior, Animal; Brain; CREB-Binding Protein; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Hippocampus; Male; Maze Learning; Microinjections; Motor Activity; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors | 2008 |
Local enhancement of cannabinoid CB1 receptor signalling in the dorsal hippocampus elicits an antidepressant-like effect.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Behavior, Animal; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Dentate Gyrus; Depression; Disease Models, Animal; Dronabinol; Hippocampus; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Stress, Psychological; Swimming | 2007 |
Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Methoxamine; Neurons, Afferent; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ruthenium Red; Time Factors; Vasodilation | 2007 |
The phytocannabinoid Delta(9)-tetrahydrocannabivarin modulates inhibitory neurotransmission in the cerebellum.
Topics: Animals; Benzoxazines; Bicuculline; Cannabinoids; Cerebellum; Dronabinol; Electrophysiology; Excitatory Postsynaptic Potentials; GABA Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Mice; Morpholines; Naphthalenes; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Synapses; Synaptic Transmission | 2008 |
Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells.
Topics: Arachidonic Acids; Caco-2 Cells; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Deoxyglucose; Dronabinol; Endocannabinoids; Humans; Indoles; Intestinal Absorption; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2008 |
Functional and immunohistochemical characterization of CB1 and CB2 receptors in rat bladder.
Topics: Animals; Calcitonin Gene-Related Peptide; Dronabinol; Female; Indoles; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tissue Culture Techniques; Urinary Bladder | 2008 |
Effects of Delta9-tetrahydrocannabivarin on [35S]GTPgammaS binding in mouse brain cerebellum and piriform cortex membranes.
Topics: Animals; Benzoxazines; Cannabinoids; Cerebellum; Data Interpretation, Statistical; Dronabinol; Electrophysiology; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Membranes; Mice; Morpholines; Naphthalenes; Olfactory Pathways; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1 | 2008 |
Release of arachidonic acid by 2-arachidonoyl glycerol and HU210 in PC12 cells; roles of Src, phospholipase C and cytosolic phospholipase A(2)alpha.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Cyclic AMP; Cytosol; Dronabinol; Endocannabinoids; Glycerides; Group IV Phospholipases A2; Mice; Mice, Inbred ICR; PC12 Cells; Phosphorylation; Piperidines; Protein Kinase C; Proto-Oncogene Proteins c-fyn; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Signal Transduction; src-Family Kinases; Type C Phospholipases | 2008 |
Cannabinoid receptor-independent cytotoxic effects of cannabinoids in human colorectal carcinoma cells: synergism with 5-fluorouracil.
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Antioxidants; Cannabinoid Receptor Antagonists; Cannabinoids; Cell Proliferation; Cell Survival; Colonic Neoplasms; Cyclic AMP; Dronabinol; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Fatty Acids, Unsaturated; Fluorouracil; Humans; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Piperidines; Pyrazoles; Receptors, Cannabinoid; Thymidine; Tumor Cells, Cultured | 2009 |
Chronic psychoemotional stress impairs cannabinoid-receptor-mediated control of GABA transmission in the striatum.
Topics: Animals; Chronic Disease; Corpus Striatum; Dronabinol; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; Glutamates; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Glucocorticoid; Social Environment; Stress, Psychological; Synaptic Transmission | 2008 |
Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning.
Topics: Animals; Conditioning, Psychological; Dentate Gyrus; Doublecortin Domain Proteins; Doublecortin Protein; Dronabinol; Fear; Freezing Reaction, Cataleptic; Gene Expression; Ki-67 Antigen; Male; Memory Disorders; Microtubule-Associated Proteins; Neural Cell Adhesion Molecule L1; Neuropeptides; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sialic Acids | 2009 |
Effect of cannabinoids upon the uptake of folic acid by BeWo cells.
Topics: Arachidonic Acids; Carrier Proteins; Cell Culture Techniques; Cell Line, Tumor; Cyclohexanols; Dronabinol; Drug Administration Schedule; Endocannabinoids; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hydrogen-Ion Concentration; Indoles; Membrane Transport Proteins; Piperidines; Placenta; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cell Surface | 2009 |
Chronic nicotine alters cannabinoid-mediated locomotor activity and receptor density in periadolescent but not adult male rats.
Topics: Adolescent; Aging; Analgesics; Animals; Cannabinoids; Cyclohexanols; Dronabinol; Female; Humans; Male; Motor Activity; Nicotine; Nicotinic Agonists; Piperidines; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid | 2009 |
Synthetic and plant-derived cannabinoid receptor antagonists show hypophagic properties in fasted and non-fasted mice.
Topics: Animals; Appetite Depressants; Cannabinoid Receptor Antagonists; Dronabinol; Eating; Fasting; Feeding Behavior; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Solvents; Weight Gain | 2009 |
Protracted cannabinoid administration elicits antidepressant behavioral responses in rats: role of gender and noradrenergic transmission.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Behavior, Animal; Cannabinoids; Desipramine; Dronabinol; Female; Male; Norepinephrine; Piperidines; Prazosin; Propranolol; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sex Characteristics; Substance Withdrawal Syndrome; Swimming; Synaptic Transmission | 2009 |
Cannabinoid CB(1) receptor activation stimulates neurite outgrowth and inhibits capsaicin-induced Ca(2+) influx in an in vitro model of diabetic neuropathy.
Topics: Animals; Calcium; Capsaicin; Diabetic Neuropathies; Dose-Response Relationship, Drug; Dronabinol; Glucose; Hyperglycemia; Indoles; Nerve Growth Factor; Neurites; Neurogenesis; Neurons; Neuroprotective Agents; PC12 Cells; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Sensory System Agents | 2009 |
Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Dronabinol; Drug Interactions; Endocannabinoids; Hypothalamo-Hypophyseal System; Male; Microinjections; Piperidines; Pituitary-Adrenal System; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Signal Transduction; Stress, Psychological | 2009 |
Voluntary exercise and sucrose consumption enhance cannabinoid CB1 receptor sensitivity in the striatum.
Topics: Animals; Baclofen; Bicuculline; Corpus Striatum; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Interactions; Excitatory Amino Acid Antagonists; Exploratory Behavior; Food Preferences; GABA Agonists; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward; Statistics, Nonparametric; Stress, Psychological; Sucrose; Time Factors | 2010 |
Involvement of cannabinoid-1 and cannabinoid-2 receptors in septic ileus.
Topics: Analysis of Variance; Animals; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Enzyme-Linked Immunosorbent Assay; Gastrointestinal Motility; Gastrointestinal Transit; Ileus; Interleukin-6; Jejunal Diseases; Jejunum; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sepsis; Tumor Necrosis Factor-alpha | 2010 |
Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Benzoxazines; Biophysics; CA1 Region, Hippocampal; Caffeine; Calcium Channel Blockers; Dronabinol; Electric Stimulation; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; GABA Antagonists; Glutamic Acid; In Vitro Techniques; Methoxyhydroxyphenylglycol; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Patch-Clamp Techniques; Phosphinic Acids; Picrotoxin; Piperidines; Presynaptic Terminals; Propanolamines; Pyrazoles; Quinoxalines; Receptor, Adenosine A1; Receptor, Cannabinoid, CB1; Xanthines | 2010 |
Precipitated withdrawal counters the adverse effects of subchronic cannabinoid administration on male rat sexual behavior.
Topics: Animals; Copulation; Dose-Response Relationship, Drug; Dronabinol; Female; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Substance Withdrawal Syndrome | 2010 |
THC Prevents MDMA Neurotoxicity in Mice.
Topics: Animals; Astrocytes; Body Temperature; Dronabinol; Fever; Hallucinogens; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Temperature | 2010 |
Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Corpus Striatum; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Fragile X Mental Retardation Protein; Gene Expression Regulation; Glycerides; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Lipoprotein Lipase; Membrane Potentials; Methoxyhydroxyphenylglycol; Mice; Mice, Knockout; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Receptors, Kainic Acid; RNA, Small Cytoplasmic; Statistics, Nonparametric | 2010 |
The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Benzoxazines; Chlorocebus aethiops; Circadian Rhythm; COS Cells; Cyclohexanols; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Drug Administration Routes; Eating; Food Deprivation; Green Fluorescent Proteins; Hemoglobins; Hyperphagia; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Peptide Fragments; Piperidines; Protein Transport; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors; Transfection | 2010 |
Brain-derived neurotrophic factor controls cannabinoid CB1 receptor function in the striatum.
Topics: Animals; Behavior, Animal; beta-Cyclodextrins; Brain-Derived Neurotrophic Factor; Cholesterol; Cocaine; Corpus Striatum; Dopamine Antagonists; Dopamine Uptake Inhibitors; Dronabinol; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; GABA Agents; Haloperidol; In Vitro Techniques; Inhibitory Postsynaptic Potentials; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; Phenols; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reward | 2010 |
Evidence for both inverse agonism at the cannabinoid CB1 receptor and the lack of an endogenous cannabinoid tone in the rat and guinea-pig isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Drug Inverse Agonism; Guinea Pigs; Ileum; Muscle Contraction; Myenteric Plexus; Piperidines; Pyrans; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
Physical and functional interaction between CB1 cannabinoid receptors and beta2-adrenoceptors.
Topics: Adrenergic beta-2 Receptor Antagonists; Cell Line; Cyclic AMP Response Element-Binding Protein; Dronabinol; Energy Transfer; Extracellular Signal-Regulated MAP Kinases; Humans; Piperidines; Pyrans; Pyrazoles; Receptor Cross-Talk; Receptor, Cannabinoid, CB1; Receptors, Adrenergic, beta-2; Signal Transduction | 2010 |
Pharmacological effects of cannabinoids on the Caco-2 cell culture model of intestinal permeability.
Topics: Algorithms; Biological Transport, Active; Caco-2 Cells; Cannabidiol; Cannabinoids; Dronabinol; Electric Impedance; Electrophysiology; Enterocytes; Humans; Intestinal Absorption; Microvilli; Permeability; Piperidines; PPAR alpha; PPAR gamma; Pyrazoles; Receptors, Cannabinoid; RNA, Messenger; Tight Junctions; TRPV Cation Channels | 2010 |
The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats.
Topics: Animals; Antiparkinson Agents; Disease Models, Animal; Dronabinol; Dyskinesia, Drug-Induced; Levodopa; Male; Parkinsonian Disorders; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2010 |
The cannabinoid CB1 receptor antagonists rimonabant (SR141716) and AM251 directly potentiate GABA(A) receptors.
Topics: Animals; Benzofurans; Dronabinol; gamma-Aminobutyric Acid; Oocytes; Piperidines; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, GABA-A; Recombinant Proteins; Rimonabant; Xenopus | 2012 |
∆(9)-Tetrahydrocannabinol decreases NOP receptor density and mRNA levels in human SH-SY5Y cells.
Topics: Cell Line, Tumor; Dose-Response Relationship, Drug; Down-Regulation; Dronabinol; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Nerve Tissue Proteins; Neuroblastoma; Nociceptin Receptor; Piperidines; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm | 2012 |
AM2389, a high-affinity, in vivo potent CB1-receptor-selective cannabinergic ligand as evidenced by drug discrimination in rats and hypothermia testing in mice.
Topics: Animals; Benzopyrans; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Time Factors | 2012 |
Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
Topics: Analgesics, Non-Narcotic; Animals; Arrestins; beta-Arrestin 1; beta-Arrestins; Body Temperature; Cannabinoids; Corpus Striatum; Dopamine Plasma Membrane Transport Proteins; Dose-Response Relationship, Drug; Dronabinol; Drug Combinations; Excitatory Amino Acid Antagonists; Female; Freezing Reaction, Cataleptic; Frontal Lobe; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Pain Perception; Phosphorylation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2011 |
Unbalance of CB1 receptors expressed in GABAergic and glutamatergic neurons in a transgenic mouse model of Huntington's disease.
Topics: Action Potentials; Analysis of Variance; Animals; Benzoxazines; Brain; Disease Models, Animal; Dronabinol; Drug Interactions; Electric Stimulation; Excitatory Amino Acid Agents; gamma-Aminobutyric Acid; Glutamates; Humans; Huntingtin Protein; Huntington Disease; In Vitro Techniques; Mice; Mice, Transgenic; Microscopy, Immunoelectron; Morpholines; Motor Activity; Naphthalenes; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Patch-Clamp Techniques; Piperidines; Potassium; Pyrazoles; Receptor, Cannabinoid, CB1; Statistics, Nonparametric; Synaptosomes; Trinucleotide Repeats; Tritium; Vesicular Glutamate Transport Protein 1; Vesicular Inhibitory Amino Acid Transport Proteins | 2012 |
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance.
Topics: Animals; Apamin; Benzamides; Biophysics; Cannabinoids; Carbamates; Conditioning, Operant; Corpus Striatum; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Guanosine 5'-O-(3-Thiotriphosphate); Habits; Long-Term Synaptic Depression; Male; Mice; Mice, Inbred C57BL; Motor Activity; Okadaic Acid; Patch-Clamp Techniques; Piperidines; Protein Binding; Pyrazoles; Rimonabant; Small-Conductance Calcium-Activated Potassium Channels; Sodium Channel Blockers; Tritium | 2012 |
The anti-nausea effects of CB1 agonists are mediated by an action at the visceral insular cortex.
Topics: Animals; Antiemetics; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cerebral Cortex; Dronabinol; Lithium Chloride; Male; Naphthalenes; Nausea; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2012 |
Ventral tegmental area cannabinoid type-1 receptors control voluntary exercise performance.
Topics: Animals; Dronabinol; Male; Mice; Mice, Knockout; Motor Activity; Neurons; Physical Conditioning, Animal; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Ventral Tegmental Area | 2013 |
Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis.
Topics: Acute Disease; Animals; Antiemetics; Cannabinoids; Cells, Cultured; Cytoprotection; Disease Models, Animal; Dronabinol; Lipopolysaccharides; Male; Organ Culture Techniques; Pancreatitis; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Serum; Stomach | 2012 |
Developmental effects of cannabinoids on zebrafish larvae.
Topics: Animals; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cyclohexanols; Dronabinol; Embryo, Nonmammalian; Female; Larva; Lethal Dose 50; Locomotion; Male; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Toxicity Tests, Acute; Toxicity Tests, Chronic; Zebrafish | 2013 |
Evaluation of the potential of the phytocannabinoids, cannabidivarin (CBDV) and Δ(9) -tetrahydrocannabivarin (THCV), to produce CB1 receptor inverse agonism symptoms of nausea in rats.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dronabinol; Drug Partial Agonism; Lithium Chloride; Male; Nausea; Phytochemicals; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2013 |
Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms.
Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Dronabinol; Indoles; Male; Mice; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Somatosensory Cortex; Tissue Culture Techniques | 2014 |
Cannabinoids reward sensitivity in a neurodevelopmental animal model of schizophrenia: a brain stimulation reward study.
Topics: Amphetamine; Analysis of Variance; Animals; Animals, Newborn; Benzoxazines; Brain; Brain Injuries; Central Nervous System Stimulants; Conditioning, Operant; Disease Models, Animal; Dronabinol; Female; Hippocampus; Male; Morpholines; Motivation; Naphthalenes; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reward; Schizophrenia; Self Administration; Time Factors | 2014 |
Cannabinoid-induced changes in respiration of brain mitochondria.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoids; Cell Respiration; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Endocannabinoids; Energy Metabolism; Mitochondria; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Swine | 2014 |
Adolescent exposure to THC in female rats disrupts developmental changes in the prefrontal cortex.
Topics: Age Factors; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Developmental Disabilities; Dizocilpine Maleate; Dronabinol; Estradiol; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Neurites; Piperidines; Prefrontal Cortex; Pyrazoles; Radionuclide Imaging; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Synaptic Potentials; Tritium | 2015 |
Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats.
Topics: Animals; Cannabinoid Receptor Agonists; Dronabinol; Electromyography; Femoral Vein; Indoles; Male; Nodose Ganglion; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin; Sleep Apnea, Obstructive; Treatment Outcome | 2014 |
Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain.
Topics: Analgesics; Animals; Cannabinoid Receptor Agonists; Dronabinol; Indoles; Injections, Intramuscular; Injections, Intraperitoneal; Male; Masseter Muscle; Muscle, Skeletal; Myalgia; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid | 2014 |
JWH-018 impairs sensorimotor functions in mice.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cornea; Dose-Response Relationship, Drug; Dronabinol; Ear Auricle; Hearing; Illicit Drugs; Indoles; Male; Mice; Movement; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reflex; Touch; Vibrissae; Video Recording; Vision, Ocular | 2015 |
Ethanol modulates facial stimulation-evoked outward currents in cerebellar Purkinje cells in vivo in mice.
Topics: Action Potentials; Animals; Benzoxazines; Central Nervous System Depressants; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dronabinol; Ethanol; gamma-Aminobutyric Acid; Isoquinolines; Membrane Potentials; Mice; Mice, Inbred ICR; Morpholines; Naphthalenes; Patch-Clamp Techniques; Physical Stimulation; Piperidines; Purkinje Cells; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Reflex; Signal Transduction; Sulfonamides; Thionucleotides | 2016 |
Effect of the novel synthetic cannabinoids AKB48 and 5F-AKB48 on "tetrad", sensorimotor, neurological and neurochemical responses in mice. In vitro and in vivo pharmacological studies.
Topics: Adamantane; Aggression; Animals; Behavior, Animal; Binding, Competitive; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabis; Catalepsy; Dopamine; Dronabinol; Humans; In Vitro Techniques; Indazoles; Indoles; Male; Mice; Motor Activity; Naphthalenes; Nucleus Accumbens; Pain Threshold; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Abnormal; Seizures | 2016 |
Natural (∆
Topics: Animals; Dose-Response Relationship, Drug; Dronabinol; Electroencephalography; Electromyography; Indoles; Locomotion; Mice; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures | 2017 |
Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats.
Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dronabinol; Electroencephalography; Electromyography; Indoles; Male; Piperidines; Polysomnography; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Respiration; Sleep; Sleep Apnea, Central; Sleep, REM; Vagus Nerve | 2017 |
Δ-9-Tetrahydrocannabinol and Cannabidiol produce dissociable effects on prefrontal cortical executive function and regulation of affective behaviors.
Topics: Affect; Animals; Anxiety; Behavior, Animal; Benzopyrans; Cannabidiol; Dizocilpine Maleate; Dose-Response Relationship, Drug; Dronabinol; Executive Function; Male; Microinjections; Piperidines; Prefrontal Cortex; Pyrazoles; Rats; Social Behavior | 2019 |
THC-induced behavioral stereotypy in zebrafish as a model of psychosis-like behavior.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Dronabinol; N-Methylaspartate; Piperidines; Psychotic Disorders; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Stereotyped Behavior; Zebrafish | 2021 |