Compounds > am 251

am 251 and am 630

am 251 has been researched along with am 630 in 105 studies

Research

Studies (105)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's32 (30.48)29.6817
2010's65 (61.90)24.3611
2020's8 (7.62)2.80

Authors

AuthorsStudies
Adinolfi, B; Benetti, V; Cascio, MG; Di Marzo, V; Ferrarini, PL; Ligresti, A; Lucchesi, V; Manera, C; Martinelli, A; Masini, E; Nieri, P; Saccomanni, G; Tuccinardi, T1
Allen, JG; Babij, P; Fotsch, C1
Brogi, S; Corelli, F; Di Marzo, V; Ligresti, A; Mugnaini, C; Pasquini, S; Tafi, A1
Chen, X; Darras, FH; Decker, M; Heilmann, J; Nimczick, M; Pemp, D1
Bánki, L; Deli, MA; Dvorácskó, S; Horváth, G; Kékesi, G; Keresztes, A; Macedonio, G; Mollica, A; Pieretti, S; Stefanucci, A; Tömböly, C; Tuboly, G; Walter, FR; Zádor, F1
Cabanlong, CV; Crooks, PA; Dachavaram, SS; Penthala, NR; Prather, PL; Shoeib, A; Yang, J; Zhan, CG1
Deng, H; Ibrahim, MM; Liu, Q; Makriyannis, A; Malan, PT; Mata, HP; Porreca, F; Vanderah, T1
Bottrill, FE; Ford, WR; Hiley, CR; Ho, WS; White, R1
Choi, JI; Yoon, MH1
Johanek, LM; Simone, DA1
Bianchi, R; Borsani, E; Buffoli, B; Rezzani, R; Ricci, F; Rodella, LF1
Baker, D; Greig, IR; Idris, AI; Ralston, SH; Ridge, SA; Ross, RA; van 't Hof, RJ1
Barun, S; Dileköz, E; Ercan, ZS; Sarioglu, Y; Vural, IM1
Beaulieu, P; De Léan, A; Guindon, J1
Abesser, M; Ertl, G; Harvey-White, J; Wagner, JA1
Fowler, CJ; Jacobsson, SO; Nilsson, O1
de la Cal, C; Elverdin, JC; Fernández-Solari, J; Iribarne, M; McCann, SM; Prestifilippo, JP; Rettori, V; Suburo, AM1
Baik, SK; Dehpour, AR; Gaskari, SA; Lee, SS; Liu, H; Moezi, L1
Beaulieu, P; Desroches, J; Guindon, J1
Bianchi, R; Borsani, E; Labanca, M; Rodella, LF1
Beaulieu, P; Dani, M; Desroches, J; Guindon, J1
Hsu, KS; Huang, CC; Liang, YC1
Beaulieu, P; Dani, M; Guindon, J; Lambert, C1
Kendall, DA; Ralevic, V; Wilkinson, JD1
Shimizu, T; Yokotani, K1
Finn, DP; Kelly, JP; O'Driscoll, M; Roche, M1
Araújo, JR; Azevedo, I; Gonçalves, P; Martel, F1
Ballesteros, I; Chancellor, MB; Coyle, CH; de Miguel, F; Hayn, MH; Tyagi, P; Tyagi, S; Yoshimura, N1
da Fonseca Pacheco, CM; da Fonseca Pacheco, D; de Castro Perez, A; de Francischi, JN; Duarte, ID; Klein, A1
Idris, AI; Landao-Bassonga, E; Ralston, SH; Sophocleous, A; van't Hof, RJ1
Araújo, JR; Gonçalves, P; Martel, F1
Chen, L; Li, F; Li, M; Li, YH; Pan, HL; Qiu, Y; Shi, J; Wang, L; Zhang, J1
Challapalli, SC; Smith, PJ; Zhang, F1
Grider, JR; Kuemmerle, JF; Li, Y; Mahavadi, S; Martin, BR; Murthy, KS; Qiao, LY1
de Francischi, JN; Duarte, ID; Klein, A; Pacheco, CM; Pacheco, Dda F; Perez, AC; Reis, GM1
Ding, Q; Dong, H; Ma, R; Su, B; Xiong, L; Zhang, X1
Lewis, AW; Neuendorff, DA; Randel, RD; Weems, CW; Weems, YS1
Touriño, C; Valverde, O; Zimmer, A1
Biwasa, KK; Hashiguchi, T; Kadomatsu, H; Kawahara, K; Kozono, S; Maruyama, I; Matsuyama, T; Nakajima, Y; Noguchi, K; Tancharoen, S; Yonamine, Y; Yoshimoto, T1
Elverdin, JC; Fernandez-Solari, J; Ossola, CA; Prestifilippo, JP; Rettori, V1
Barrett, F; Keown, OP; Leslie, SJ; Macrury, SM; Megson, IL; Neilson, I; Wainwright, CL; Winterburn, TJ1
Chambers, MG; Jassal, K; Johnson, MP; McDougall, JJ; Oskins, JL; Schuelert, N1
Grinfeld, E; Hryciw, DH; Jenkin, KA; McAinch, AJ1
Azcoitia, I; Bellini, MJ; Bermudez-Silva, FJ; Garcia-Segura, LM; López Rodríguez, AB; Mateos Vicente, B; Rodriguez de Fonseca, F; Rodriguez-Rodriguez, N; Romero-Zerbo, SY; Viveros, MP1
Abalo, R; González, C; Herradón, E; Leza, JC; López-Miranda, V; Martín, MI; Pérez-Nievas, BG; Vera, G1
Carlson, OD; Doyle, ME; Egan, JM; Kim, HS; Kim, W; Kulkarni, RN; Lao, Q; Lee, EK; Liu, Z; Martin, B; Maudsley, S; Moaddel, R; Napora, JK; Shin, YK; Thomas, S; Wang, Y1
Akopian, AN; Hargreaves, KM; Patil, M; Patwardhan, A; Salas, MM1
Feng, JY; Feng, YJ; Li, K; Li, YN; Li, YY; Lin, XH; Storr, M; Yu, LY; Yuece, B1
Alhamoruni, A; Larvin, M; O'Sullivan, SE; Wright, KL1
Funada, M; Tomiyama, K1
Fang, Q; Han, ZL; He, N; Li, N; Wang, R; Wang, ZL1
Hervera, A; Leánez, S; Martín-Campos, JM; Negrete, R; Pol, O1
Li, DP; Li, Q; Ma, HJ; Shi, M; Song, SL; Zhang, Y1
Keresztes, A; Largent-Milnes, TM; Ren, J; Roeske, WR; Tumati, S; Vanderah, TW; Varga, EV1
Bagües Arias, A; Martín Fontelles, MI; Sánchez Robles, EM1
Baranowska-Kuczko, M; Kozłowska, H; MacLean, MR; Malinowska, B1
De Laurentiis, A; Elverdin, JC; Rettori, E; Rettori, V; Zorrilla Zubilete, M1
Deng, L; Guindon, J; Hohmann, AG; Makriyannis, A; Thakur, GA; Vemuri, VK; White, FA1
Duarte, ID; Pacheco, Dda F; Romero, TR1
Araújo, JC; Brito, GA; Cavalcante, AL; Gondim, DV; Havt, A; Lima Vale, M; Quetz, Jda S; Ribeiro, Rde A1
Li, Q; Wang, SY; Wei, Y; Yang, J; Zhang, J; Zhang, Y; Zhou, JJ1
Cui, N; Du, Y; Li, Q; Ma, H; Zhang, Y1
Aguiar, DC; Almeida-Santos, AF; Gobira, PH; Guimaraes, FS; Moreira, FA; Rosa, LC1
Ferraz, JG; Flannigan, KL; McKnight, W; Tuitt, D; Wallace, JL; Wang, L1
Finn, DP; Garcia-Segura, LM; Jafarian-Tehrani, M; Lopez-Rodriguez, AB; Marchand-Leroux, C; Siopi, E; Viveros, MP1
Aguiar, DC; Cruz, JS; de Paula, AM; Di Marzo, V; Duarte, ID; Galdino, G; Parrella, C; Perez, AC; Piscitelli, F; Romero, TR; Silva, JF1
Hinz, B; Peters, K; Ramer, R; Salamon, A; Schmuhl, E1
Al Kury, LT; Ali, RM; Galadari, S; Howarth, FC; Oz, M; Shuba, YM; Voitychuk, OI; Yang, KH1
Bradshaw, HB; Cygankiewicz, A; Fichna, J; Kordek, R; Krajewska, WM; Leishman, E; Małecka-Panas, E; Mokrowiecka, A; Sałaga, M; Sobczak, M; Storr, M; Zakrzewski, PK; Zatorski, H1
Keller, A; Raver, SM1
Krustev, E; McDougall, JJ; Reid, A1
Calik, MW; Carley, DW2
Bagüés, A; Martín, MI; Sánchez-Robles, EM1
Chen, CY; Chi, CW; Li, CP; Ting, CH1
Biala, G; Kruk-Slomka, M; Michalak, A1
Gao, F; Ji, M; Li, F; Li, Q; Miao, Y; Qian, WJ; Sun, XH; Wang, SY; Wang, Z; Yang, W1
Biala, G; Boguszewska-Czubara, A; Budzynska, B; Kruk-Slomka, M; Slomka, T1
Bakali, E; Elliott, RA; Lambert, DG; Mason, R; Mbaki, Y; Tincello, DG1
Beierschmitt, A; Bouchard, JF; Bouskila, J; Casanova, C; Harrar, V; Javadi, P; Palmour, R; Ptito, M1
Adams, MJ; Geraghty, DP; Kunde, DA; Omari, SA1
Chancellor, MB; Hikita, K; Honda, M; Kawamoto, B; Muraoka, K; Saito, M; Shimizu, S; Takenaka, A; Yoshimura, N1
Engidawork, E; Geresu, B; Onaivi, E1
Baggio, CH; Bertoglio, LJ; Cristina de Carvalho, M; Cunha, JM; da Silva, LM; da Silva-Santos, JE; de Morais, H; de Souza, CP; Ferreira, DM; Vanvossen, AC; Zanoveli, JM1
Hinz, B; Ivanov, I; Scholl, A1
Almeida, RT; de Souza, GG; Duarte, ID; Perez, AC; Romero, MG; Romero, TR1
Amini-Khoei, H; Amiri, S; Dehpour, AR; Ghesmati, M; Haj-Mirzaian, A; Shafaroodi, H; Zahir, M1
Calixto, JB; Costa, R; Freitas, CS; Manjavachi, MN; Matias, DO; Passos, GF; Segat, GC1
Fang, B; Jing, N; Ma, H; Wang, ZL1
Fichna, J; Misicka, A; Sacharczuk, M; Wasilewski, A1
Anli, G; Bilir, KA; Gunduz, O; Ozkan, E; Ulugol, A1
Fang, Q; Shi, X; Wang, P; Xu, B; Zhang, M; Zhang, Q; Zhang, R; Zhang, T; Zhao, W; Zheng, T1
Hohmann, AG; Iyer, V; Makriyannis, A; Saberi, SA; Slivicki, RA; Vemuri, VK1
Kossakowski, R; Malinowska, B; Pędzińska-Betiuk, A; Weresa, J1
Aguiar, DC; Bastos, JR; Coimbra, CC; Costa, RB; Hott, SC; Mansur, FS; Moreira, FA; Resstel, LB; Viana, TG1
Duarte, IDG; Pacheco, DDF; Romero, TRL1
Bi, GH; Galaj, E; He, Y; Xi, ZX1
Ali, DW; Allison, WT; Amin, MR; Kanyo, R; Sufian, MS1
Arslan, R; Bektas, N; Dikmen, DY; Okcay, Y1
Babaie, J; Ghanbari, MM; Joneidi, M; Kiani, B; Sayyah, M1
Liu, S; Liu, X; Lu, Y; Wu, Y; Xie, Y; Yang, R; Zhou, D; Zhou, Y1
Chung, YC; Jin, BK; Wi, R1
Escayg, A; Gado, F; Manera, C; Shapiro, L1
Ghanbari, MM; Loron, AG; Sayyah, M1
Hara, K; Haranishi, Y; Terada, T1

Reviews

1 review(s) available for am 251 and am 630

ArticleYear
Emerging targets in osteoporosis disease modification.
    Journal of medicinal chemistry, 2010, Jun-10, Volume: 53, Issue:11

    Topics: Animals; Biomarkers; Bone Density; Bone Resorption; Humans; Osteoporosis

2010

Other Studies

104 other study(ies) available for am 251 and am 630

ArticleYear
Rational design, synthesis, and pharmacological properties of new 1,8-naphthyridin-2(1H)-on-3-carboxamide derivatives as highly selective cannabinoid-2 receptor agonists.
    Journal of medicinal chemistry, 2009, Jun-25, Volume: 52, Issue:12

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drug Design; Drug Evaluation, Preclinical; Humans; Jurkat Cells; Models, Molecular; Molecular Structure; Naphthyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship

2009
Three-dimensional quantitative structure-selectivity relationships analysis guided rational design of a highly selective ligand for the cannabinoid receptor 2.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Drug Design; Humans; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Quinolones; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Recombinant Proteins; Stereoisomerism

2011
Synthesis and biological evaluation of bivalent cannabinoid receptor ligands based on hCB₂R selective benzimidazoles reveal unexpected intrinsic properties.
    Bioorganic & medicinal chemistry, 2014, Aug-01, Volume: 22, Issue:15

    Topics: Benzimidazoles; Drug Design; Humans; Kinetics; Ligands; Protein Binding; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2014
Preparation of bivalent agonists for targeting the mu opioid and cannabinoid receptors.
    European journal of medicinal chemistry, 2019, Sep-15, Volume: 178

    Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Enkephalins; Indoles; Mice; Molecular Structure; Naphthalenes; Oxycodone; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, mu; Structure-Activity Relationship

2019
7-Azaindolequinuclidinones (7-AIQD): A novel class of cannabinoid 1 (CB1) and cannabinoid 2 (CB2) receptor ligands.
    Bioorganic & medicinal chemistry letters, 2020, 11-15, Volume: 30, Issue:22

    Topics: Aza Compounds; Dose-Response Relationship, Drug; Humans; Indoles; Ligands; Molecular Structure; Quinuclidines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Structure-Activity Relationship

2020
CB2 cannabinoid receptor-mediated peripheral antinociception.
    Pain, 2001, Volume: 93, Issue:3

    Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Indoles; Male; Morpholines; Naphthalenes; Pain Measurement; Peripheral Nervous System; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug

2001
Mechanisms of anandamide-induced vasorelaxation in rat isolated coronary arteries.
    British journal of pharmacology, 2001, Volume: 134, Issue:4

    Topics: Amides; Animals; Arachidonic Acids; Capsaicin; Coronary Vessels; Dose-Response Relationship, Drug; Endocannabinoids; Endothelium, Vascular; Ethanolamines; Gap Junctions; Glycyrrhetinic Acid; In Vitro Techniques; Indoles; Indomethacin; Male; Palmitic Acids; Peptides; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Serotonin; Tetraethylammonium; Vasodilation

2001
Pharmacologic interaction between cannabinoid and either clonidine or neostigmine in the rat formalin test.
    Anesthesiology, 2003, Volume: 99, Issue:3

    Topics: Adrenergic alpha-Agonists; Analgesics; Animals; Antineoplastic Agents; Behavior, Animal; Benzoxazines; Cannabinoids; Cholinesterase Inhibitors; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; Indoles; Injections, Spinal; Male; Morpholines; Naphthalenes; Neostigmine; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug

2003
Activation of peripheral cannabinoid receptors attenuates cutaneous hyperalgesia produced by a heat injury.
    Pain, 2004, Volume: 109, Issue:3

    Topics: Animals; Benzoxazines; Burns; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Hot Temperature; Hyperalgesia; Indoles; Male; Morpholines; Naphthalenes; Nerve Fibers, Myelinated; Nerve Fibers, Unmyelinated; Nociceptors; Pain; Pain Measurement; Physical Stimulation; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Reflex; Skin

2004
AM404, an inhibitor of anandamide reuptake decreases Fos-immunoreactivity in the spinal cord of neuropathic rats after non-noxious stimulation.
    European journal of pharmacology, 2005, Jan-31, Volume: 508, Issue:1-3

    Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Dose-Response Relationship, Drug; Endocannabinoids; Immunohistochemistry; Indoles; Male; Physical Stimulation; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord

2005
Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors.
    Nature medicine, 2005, Volume: 11, Issue:7

    Topics: Animals; Apoptosis; Bone and Bones; Bone Density; Bone Resorption; Camphanes; Carrier Proteins; Cells, Cultured; Female; Indoles; Ligands; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteoclasts; Ovariectomy; Piperidines; Pyrazoles; Rabbits; RANK Ligand; Receptor Activator of Nuclear Factor-kappa B; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2005
Effects of cannabinoid receptor activation on rabbit bisected vas deferens strips.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:9

    Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Dose-Response Relationship, Drug; Endocannabinoids; In Vitro Techniques; Indoles; Male; Morpholines; Muscle Contraction; Muscle, Smooth; Naloxone; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Sympathetic Nervous System; Vas Deferens

2005
Local interactions between anandamide, an endocannabinoid, and ibuprofen, a nonsteroidal anti-inflammatory drug, in acute and inflammatory pain.
    Pain, 2006, Volume: 121, Issue:1-2

    Topics: Acute Disease; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Area Under Curve; Cannabinoid Receptor Modulators; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Endocannabinoids; Ibuprofen; Indoles; Inflammation; Male; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Random Allocation; Rats

2006
2-Arachidonylglycerol acting on CB1 cannabinoid receptors mediates delayed cardioprotection induced by nitric oxide in rat isolated hearts.
    Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:5

    Topics: Animals; Arachidonic Acids; Blood Pressure; Cannabinoid Receptor Modulators; Coronary Vessels; Endocannabinoids; Glycerides; Heart; Heart Rate; Indoles; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Donors; Nitroglycerin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Regional Blood Flow

2006
The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
    European journal of pharmacology, 2006, Oct-10, Volume: 547, Issue:1-3

    Topics: Analysis of Variance; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cell Movement; Chemotaxis; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Flow Cytometry; Humans; Indoles; Interleukin-8; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Thapsigargin; Tumor Necrosis Factor-alpha

2006
Inhibition of salivary secretion by activation of cannabinoid receptors.
    Experimental biology and medicine (Maywood, N.J.), 2006, Volume: 231, Issue:8

    Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Colforsin; Cyclic AMP; Endocannabinoids; Immunohistochemistry; Indoles; Male; Methacholine Chloride; Norepinephrine; Parasympathomimetics; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Saliva; Submandibular Gland; Sympathomimetics

2006
Anandamide mediates hyperdynamic circulation in cirrhotic rats via CB(1) and VR(1) receptors.
    British journal of pharmacology, 2006, Volume: 149, Issue:7

    Topics: Animals; Arachidonic Acids; Bile Ducts; Blood Flow Velocity; Blood Pressure; Blotting, Western; Capsaicin; Cardiac Output; Disease Models, Animal; Endocannabinoids; Hyperemia; Indoles; Liver Circulation; Liver Cirrhosis, Biliary; Male; Mesenteric Artery, Superior; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Circulation; Time Factors; TRPV Cation Channels; Vascular Resistance; Vasodilation; Vasodilator Agents

2006
The antinociceptive effects of intraplantar injections of 2-arachidonoyl glycerol are mediated by cannabinoid CB2 receptors.
    British journal of pharmacology, 2007, Volume: 150, Issue:6

    Topics: Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Biphenyl Compounds; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Glycerides; Indoles; Male; Monoacylglycerol Lipases; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2007
AM404 decreases Fos-immunoreactivity in the spinal cord in a model of inflammatory pain.
    Brain research, 2007, Jun-04, Volume: 1152

    Topics: Animals; Arachidonic Acids; Capsaicin; Endocannabinoids; Immunohistochemistry; Indoles; Inflammation; Male; Pain; Pain Measurement; Piperidines; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-fos; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Spinal Cord; TRPV Cation Channels

2007
Pre-emptive antinociceptive effects of a synthetic cannabinoid in a model of neuropathic pain.
    European journal of pharmacology, 2007, Jul-30, Volume: 568, Issue:1-3

    Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Hyperalgesia; Indoles; Male; Morpholines; Naphthalenes; Pain; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sciatic Nerve; Sciatic Neuropathy

2007
The synthetic cannabinoids attenuate allodynia and hyperalgesia in a rat model of trigeminal neuropathic pain.
    Neuropharmacology, 2007, Volume: 53, Issue:1

    Topics: Analgesics; Analysis of Variance; Animals; Benzoxazines; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Functional Laterality; Hyperalgesia; Hyperesthesia; Indoles; Male; Morpholines; Naphthalenes; Pain Measurement; Pain Threshold; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Time Factors; Trigeminal Nerve Diseases

2007
The local antinociceptive effects of paracetamol in neuropathic pain are mediated by cannabinoid receptors.
    European journal of pharmacology, 2007, Nov-14, Volume: 573, Issue:1-3

    Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Sciatic Nerve

2007
Delta 9-tetrahydrocannabinol inhibits electrically-evoked CGRP release and capsaicin-sensitive sensory neurogenic vasodilatation in the rat mesenteric arterial bed.
    British journal of pharmacology, 2007, Volume: 152, Issue:5

    Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Electric Stimulation; Indoles; Male; Mesenteric Arteries; Methoxamine; Neurons, Afferent; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Ruthenium Red; Time Factors; Vasodilation

2007
Bidirectional roles of the brain 2-arachidonoyl-sn-glycerol in the centrally administered vasopressin-induced adrenomedullary outflow in rats.
    European journal of pharmacology, 2008, Mar-17, Volume: 582, Issue:1-3

    Topics: Adrenal Medulla; Animals; Arachidonic Acids; Arginine Vasopressin; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catecholamines; Cyclohexanones; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Epinephrine; Glycerides; Indoles; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Norepinephrine; Organophosphonates; Piperidines; Pyrazoles; Rats; Rats, Wistar

2008
Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats.
    Immunology, 2008, Volume: 125, Issue:2

    Topics: Anilides; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cinnamates; Cytokines; Drug Synergism; Indoles; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha

2008
Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells.
    Pharmacology, 2008, Volume: 82, Issue:1

    Topics: Arachidonic Acids; Caco-2 Cells; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Deoxyglucose; Dronabinol; Endocannabinoids; Humans; Indoles; Intestinal Absorption; Piperidines; Polyunsaturated Alkamides; Pyrazoles

2008
Functional and immunohistochemical characterization of CB1 and CB2 receptors in rat bladder.
    Urology, 2008, Volume: 72, Issue:5

    Topics: Animals; Calcitonin Gene-Related Peptide; Dronabinol; Female; Indoles; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tissue Culture Techniques; Urinary Bladder

2008
The mu-opioid receptor agonist morphine, but not agonists at delta- or kappa-opioid receptors, induces peripheral antinociception mediated by cannabinoid receptors.
    British journal of pharmacology, 2008, Volume: 154, Issue:5

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Arachidonic Acids; Benzamides; Benzomorphans; Cannabinoid Receptor Modulators; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hyperalgesia; Indoles; Male; Morphine; Organophosphonates; Pain; Pain Measurement; Piperazines; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2008
Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type 2 cannabinoid receptor.
    Endocrinology, 2008, Volume: 149, Issue:11

    Topics: Animals; Bone and Bones; Bone Density; Bone Marrow Cells; Bone Resorption; Cannabinoids; Cells, Cultured; Coculture Techniques; Drug Evaluation, Preclinical; Drug Inverse Agonism; Female; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Size; Osteoclasts; Ovariectomy; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2

2008
Effect of cannabinoids upon the uptake of folic acid by BeWo cells.
    Pharmacology, 2009, Volume: 83, Issue:3

    Topics: Arachidonic Acids; Carrier Proteins; Cell Culture Techniques; Cell Line, Tumor; Cyclohexanols; Dronabinol; Drug Administration Schedule; Endocannabinoids; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hydrogen-Ion Concentration; Indoles; Membrane Transport Proteins; Piperidines; Placenta; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cell Surface

2009
Endogenous anandamide and cannabinoid receptor-2 contribute to electroacupuncture analgesia in rats.
    The journal of pain, 2009, Volume: 10, Issue:7

    Topics: Animals; Arachidonic Acids; Chromatography, High Pressure Liquid; Electroacupuncture; Endocannabinoids; Freund's Adjuvant; Hindlimb; Hot Temperature; Hyperalgesia; Indoles; Male; Pain; Pain Management; Physical Stimulation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Skin

2009
Cannabinoid CB(1) receptor activation stimulates neurite outgrowth and inhibits capsaicin-induced Ca(2+) influx in an in vitro model of diabetic neuropathy.
    Neuropharmacology, 2009, Volume: 57, Issue:2

    Topics: Animals; Calcium; Capsaicin; Diabetic Neuropathies; Dose-Response Relationship, Drug; Dronabinol; Glucose; Hyperglycemia; Indoles; Nerve Growth Factor; Neurites; Neurogenesis; Neurons; Neuroprotective Agents; PC12 Cells; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Sensory System Agents

2009
Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 297, Issue:3

    Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Colon; Dose-Response Relationship, Drug; Endocannabinoids; Guinea Pigs; In Vitro Techniques; Indoles; Motor Neurons; Neural Inhibition; Peristalsis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Sensory Receptor Cells; Substance P; Vasoactive Intestinal Peptide

2009
Central antinociception induced by mu-opioid receptor agonist morphine, but not delta- or kappa-, is mediated by cannabinoid CB1 receptor.
    British journal of pharmacology, 2009, Volume: 158, Issue:1

    Topics: Analgesics, Opioid; Animals; Indoles; Male; Mice; Morphine; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

2009
Cannabinoid 1 receptor mediation of spinal cord ischemic tolerance induced by limb remote ischemia preconditioning in rats.
    The Journal of thoracic and cardiovascular surgery, 2009, Volume: 138, Issue:6

    Topics: Animals; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Indoles; Ischemia; Ischemic Preconditioning; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reperfusion Injury; Spinal Cord

2009
Endocannabinoid 1 and 2 (CB(1); CB(2)) receptor agonists affect negatively cow luteal function in vitro.
    Prostaglandins & other lipid mediators, 2009, Volume: 90, Issue:3-4

    Topics: Adenine; Adenosine; Animals; Arachidonic Acids; Cattle; Corpus Luteum; Dinoprost; Dinoprostone; Female; In Vitro Techniques; Indoles; Organophosphonates; Piperidines; Pregnancy; Progesterone; Pyrazoles; Pyrrolidines; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2009
THC Prevents MDMA Neurotoxicity in Mice.
    PloS one, 2010, Feb-10, Volume: 5, Issue:2

    Topics: Animals; Astrocytes; Body Temperature; Dronabinol; Fever; Hallucinogens; Indoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; N-Methyl-3,4-methylenedioxyamphetamine; Neurotoxicity Syndromes; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Temperature

2010
Involvement of the endocannabinoid system in periodontal healing.
    Biochemical and biophysical research communications, 2010, Apr-16, Volume: 394, Issue:4

    Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cell Proliferation; Endocannabinoids; Fibroblasts; Gingival Crevicular Fluid; Glycerides; Humans; Indoles; p38 Mitogen-Activated Protein Kinases; Periodontium; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Wound Healing

2010
Participation of the endocannabinoid system in lipopolysaccharide-induced inhibition of salivary secretion.
    Archives of oral biology, 2010, Volume: 55, Issue:8

    Topics: Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoid Receptor Modulators; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Endocannabinoids; Etanercept; Immunoglobulin G; Immunologic Factors; In Vitro Techniques; Indoles; Lipopolysaccharides; Male; Methacholine Chloride; Muscarinic Agonists; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Tumor Necrosis Factor; Recombinant Fusion Proteins; Saliva; Salivation; Secretory Rate; Submandibular Gland; Tumor Necrosis Factor-alpha

2010
2-arachidonyl glycerol activates platelets via conversion to arachidonic acid and not by direct activation of cannabinoid receptors.
    British journal of clinical pharmacology, 2010, Volume: 70, Issue:2

    Topics: Adolescent; Adult; Aged; Arachidonic Acids; Aspirin; Blood Platelets; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Coronary Artery Disease; Endocannabinoids; Glycerides; Humans; Indoles; Male; Middle Aged; Piperidines; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Pyrazoles; Young Adult

2010
Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis.
    Pain, 2011, Volume: 152, Issue:5

    Topics: Action Potentials; Afferent Pathways; Age Factors; Animals; Arthralgia; Benzamides; Carbamates; Diclofenac; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guinea Pigs; Indoles; Iodoacetic Acid; Male; Nociceptors; Osteoarthritis; Piperidines; Pyrazoles; Rats; Rats, Wistar; Time Factors; Weight-Bearing

2011
Role for cannabinoid receptors in human proximal tubular hypertrophy.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2010, Volume: 26, Issue:6

    Topics: Animals; Arachidonic Acids; Cell Enlargement; Cell Line; Endocannabinoids; Humans; Indoles; Kidney Tubules, Proximal; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; TRPV Cation Channels

2010
Estradiol decreases cortical reactive astrogliosis after brain injury by a mechanism involving cannabinoid receptors.
    Cerebral cortex (New York, N.Y. : 1991), 2011, Volume: 21, Issue:9

    Topics: Animals; Brain Injuries; Cannabinoid Receptor Modulators; Cannabinoids; Cerebral Cortex; Estradiol; Glial Fibrillary Acidic Protein; Gliosis; Immunohistochemistry; Indoles; Male; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; RNA, Messenger; Stereotaxic Techniques; Tissue Fixation; Vimentin; Wounds, Stab

2011
Cannabinoid/agonist WIN 55,212-2 reduces cardiac ischaemia–reperfusion injury in Zucker diabetic fatty rats: role of CB2 receptors and iNOS/eNOS.
    Diabetes/metabolism research and reviews, 2011, Volume: 27, Issue:4

    Topics: Animals; Benzoxazines; Cannabinoids; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Type 2; Heart; Heart Rate; Indoles; Male; Morpholines; Myocardial Ischemia; Myocardial Reperfusion Injury; Naphthalenes; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Piperidines; Pyrazoles; Rats; Rats, Zucker; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2011
Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells.
    Diabetes, 2011, Volume: 60, Issue:4

    Topics: Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Female; Glucose; GTP-Binding Protein alpha Subunit, Gi2; Humans; Immunoprecipitation; In Vitro Techniques; Indoles; Insulin-Secreting Cells; Male; Mice; Mice, Mutant Strains; Mice, Obese; Piperidines; Potassium Chloride; Protein Binding; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Insulin; Signal Transduction

2011
Cannabinoid receptor antagonists AM251 and AM630 activate TRPA1 in sensory neurons.
    Neuropharmacology, 2011, Volume: 61, Issue:4

    Topics: Animals; Cannabinoid Receptor Antagonists; CHO Cells; Cricetinae; Cricetulus; Indoles; Mice; Mice, 129 Strain; Mice, Knockout; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Sensory Receptor Cells; Transient Receptor Potential Channels; TRPA1 Cation Channel

2011
A novel CB receptor GPR55 and its ligands are involved in regulation of gut movement in rodents.
    Neurogastroenterology and motility, 2011, Volume: 23, Issue:9

    Topics: Animals; Cannabidiol; Electromyography; Gastrointestinal Motility; Gastrointestinal Transit; Indoles; Inflammation; Interleukin-6; Intestines; Ligands; Lipopolysaccharides; Membrane Potentials; Mice; Mice, Inbred C57BL; Myocytes, Smooth Muscle; Piperidines; Pyrazoles; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Tumor Necrosis Factor-alpha

2011
Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability.
    British journal of pharmacology, 2012, Volume: 165, Issue:8

    Topics: Amidohydrolases; Benzamides; Benzodioxoles; Caco-2 Cells; Cannabinoids; Carbamates; Cell Survival; Enzyme Inhibitors; Humans; Indoles; Inflammation; Interferon-gamma; Intestinal Mucosa; Monoacylglycerol Lipases; Permeability; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Tumor Necrosis Factor-alpha

2012
Cytotoxicity of synthetic cannabinoids found in "Spice" products: the role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line.
    Toxicology letters, 2011, Nov-10, Volume: 207, Issue:1

    Topics: Apoptosis; Cannabinoids; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Cell Survival; Cyclohexanols; Cysteine Proteinase Inhibitors; Drug Interactions; Humans; Indoles; Microscopy, Fluorescence; Oligopeptides; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2011
Effects of neuropeptide FF system on CB₁ and CB₂ receptors mediated antinociception in mice.
    Neuropharmacology, 2012, Volume: 62, Issue:2

    Topics: Analgesia; Analgesics; Animals; Benzoxazines; Indoles; Male; Mice; Morpholines; Naloxone; Naphthalenes; Oligopeptides; Pain; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2012
The antinociceptive effects of JWH-015 in chronic inflammatory pain are produced by nitric oxide-cGMP-PKG-KATP pathway activation mediated by opioids.
    PloS one, 2011, Volume: 6, Issue:10

    Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclic GMP; Glyburide; Indoles; KATP Channels; Mice; Mice, Knockout; Naloxone; Nitric Oxide; Nitric Oxide Synthase Type I; Pain; Piperidines; Pyrazoles; Quaternary Ammonium Compounds; Receptors, Cannabinoid; Signal Transduction; Thionucleotides

2011
Effects of anandamide on potassium channels in rat ventricular myocytes: a suppression of I(to) and augmentation of K(ATP) channels.
    American journal of physiology. Cell physiology, 2012, Mar-15, Volume: 302, Issue:6

    Topics: Animals; Anti-Arrhythmia Agents; Arachidonic Acids; Arrhythmias, Cardiac; Cardiac Electrophysiology; Dose-Response Relationship, Drug; Endocannabinoids; Heart Ventricles; Indoles; KATP Channels; Male; Myocytes, Cardiac; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2012
Repeated morphine treatment-mediated hyperalgesia, allodynia and spinal glial activation are blocked by co-administration of a selective cannabinoid receptor type-2 agonist.
    Journal of neuroimmunology, 2012, Volume: 244, Issue:1-2

    Topics: Analgesics; Analgesics, Opioid; Animals; Cannabinoids; Hyperalgesia; Indoles; Inflammation; Interleukin-1beta; Male; Morphine; Neuroglia; Pain; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Spinal Cord; Tumor Necrosis Factor-alpha

2012
Cannabinoids and muscular pain. Effectiveness of the local administration in rat.
    European journal of pain (London, England), 2012, Volume: 16, Issue:8

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Indoles; Male; Morpholines; Motor Activity; Musculoskeletal Pain; Naphthalenes; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar; Treatment Outcome

2012
Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.
    Pharmacological research, 2012, Volume: 66, Issue:3

    Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amidohydrolases; Animals; Anisoles; Apamin; Arachidonic Acids; Benzamides; Benzyl Compounds; Cannabinoid Receptor Antagonists; Capsaicin; Carbamates; Charybdotoxin; Cyclohexanes; Endocannabinoids; Endothelium, Vascular; Imidazoles; Indoles; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Pulmonary Artery; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Epoprostenol; Tetraethylammonium; TRPV Cation Channels; Vasodilation

2012
Anti-inflammatory effect of the endocannabinoid anandamide in experimental periodontitis and stress in the rat.
    Neuroimmunomodulation, 2012, Volume: 19, Issue:5

    Topics: Alveolar Bone Loss; Animals; Anti-Inflammatory Agents; Arachidonic Acids; Body Weight; Cannabinoid Receptor Agonists; Corticosterone; Disease Models, Animal; Endocannabinoids; Enzyme-Linked Immunosorbent Assay; Exploratory Behavior; Indoles; Interleukin-1beta; Male; Nitric Oxide Synthase; Periodontitis; Piperidines; Polyunsaturated Alkamides; Prostaglandins E; Pyrazoles; Rats; Rats, Wistar; Statistics, Nonparametric; Stress, Psychological; Tumor Necrosis Factor-alpha

2012
The maintenance of cisplatin- and paclitaxel-induced mechanical and cold allodynia is suppressed by cannabinoid CB₂ receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy.
    Molecular pain, 2012, Sep-22, Volume: 8

    Topics: Animals; Benzylamines; Chromones; Cisplatin; Cryopyrin-Associated Periodic Syndromes; Cyclams; Disease Models, Animal; Heterocyclic Compounds; Hyperalgesia; Indoles; Male; Paclitaxel; Peripheral Nervous System Diseases; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, CXCR4; Signal Transduction; Time Factors; Treatment Outcome

2012
Probable involvement of Ca(2+)-activated Cl(-) channels (CaCCs) in the activation of CB1 cannabinoid receptors.
    Life sciences, 2013, May-02, Volume: 92, Issue:14-16

    Topics: Amides; Analysis of Variance; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Agonists; Chloride Channels; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Ethanolamines; Hyperalgesia; Indoles; Male; Niflumic Acid; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2013
CB1 and CB2 contribute to antinociceptive and anti-inflammatory effects of electroacupuncture on experimental arthritis of the rat temporomandibular joint.
    Canadian journal of physiology and pharmacology, 2012, Volume: 90, Issue:11

    Topics: Acupuncture Analgesia; Animals; Arthritis, Experimental; Behavior, Animal; Down-Regulation; Electroacupuncture; Indoles; Male; Nerve Tissue Proteins; Nociception; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Temporomandibular Joint; Trigeminal Nucleus, Spinal; Up-Regulation; Zymosan

2012
Inhibitory effects of endocannabinoid on the action potential of pacemaker cells in sinoatrial nodes of rabbits.
    Sheng li xue bao : [Acta physiologica Sinica], 2013, Apr-25, Volume: 65, Issue:2

    Topics: Action Potentials; Animals; Arachidonic Acids; Cannabinoid Receptor Antagonists; Endocannabinoids; Indoles; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Pyrazoles; Rabbits; Sinoatrial Node

2013
Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes.
    PloS one, 2013, Volume: 8, Issue:5

    Topics: Aniline Compounds; Animals; Arachidonic Acids; Calcium; Cannabinoids; Cell Separation; Endocannabinoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heart Ventricles; Indoles; Intracellular Space; Ion Channel Gating; Male; Myocardial Ischemia; Myocytes, Cardiac; Pertussis Toxin; Phenyl Ethers; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Sodium-Calcium Exchanger; Solutions

2013
Modulation of anxiety-like behavior by the endocannabinoid 2-arachidonoylglycerol (2-AG) in the dorsolateral periaqueductal gray.
    Behavioural brain research, 2013, Sep-01, Volume: 252

    Topics: Analysis of Variance; Animals; Anxiety; Arachidonic Acids; Biphenyl Compounds; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Glycerides; Indoles; Male; Maze Learning; Periaqueductal Gray; Piperidines; Pyrazoles; Rats; Rats, Wistar

2013
Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2013, Volume: 64, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabis; Colitis; Gastrointestinal Tract; Hydrogen Sulfide; Indoles; Male; Naproxen; Piperidines; Plant Extracts; Protective Agents; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Stomach Ulcer; Visceral Pain

2013
CB1 and CB2 cannabinoid receptor antagonists prevent minocycline-induced neuroprotection following traumatic brain injury in mice.
    Cerebral cortex (New York, N.Y. : 1991), 2015, Volume: 25, Issue:1

    Topics: Animals; Axons; Brain; Brain Edema; Brain Injuries; Cannabinoid Receptor Antagonists; Indoles; Male; Mice; Microglia; Minocycline; Motor Activity; Neuroprotective Agents; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2015
The endocannabinoid system mediates aerobic exercise-induced antinociception in rats.
    Neuropharmacology, 2014, Volume: 77

    Topics: Analgesia; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Modulators; Endocannabinoids; Indoles; Male; Organophosphonates; Pain Measurement; Physical Conditioning, Animal; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1

2014
Increase of mesenchymal stem cell migration by cannabidiol via activation of p42/44 MAPK.
    Biochemical pharmacology, 2014, Feb-01, Volume: 87, Issue:3

    Topics: Cannabidiol; Cannabinoids; Cell Differentiation; Cell Movement; Cells, Cultured; Cyclohexanes; Flavonoids; Gene Expression Regulation, Enzymologic; Humans; Indoles; Mesenchymal Stem Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Osteoblasts; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB2; Resorcinols

2014
Effects of endogenous cannabinoid anandamide on excitation-contraction coupling in rat ventricular myocytes.
    Cell calcium, 2014, Volume: 55, Issue:2

    Topics: Action Potentials; Animals; Arachidonic Acids; Caffeine; Calcium; Calcium Signaling; Endocannabinoids; Fura-2; Heart Ventricles; In Vitro Techniques; Indoles; Male; Myocardial Contraction; Myocytes, Cardiac; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sarcoplasmic Reticulum; Transport Vesicles

2014
Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).
    Journal of Crohn's & colitis, 2014, Volume: 8, Issue:9

    Topics: Amidohydrolases; Animals; Cannabinoids; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Treatment Outcome

2014
Permanent suppression of cortical oscillations in mice after adolescent exposure to cannabinoids: receptor mechanisms.
    Neuropharmacology, 2014, Volume: 86

    Topics: Animals; Benzoxazines; Cannabinoid Receptor Modulators; Dronabinol; Indoles; Male; Mice; Morpholines; Naphthalenes; Piperidines; Prefrontal Cortex; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Somatosensory Cortex; Tissue Culture Techniques

2014
Tapping into the endocannabinoid system to ameliorate acute inflammatory flares and associated pain in mouse knee joints.
    Arthritis research & therapy, 2014, Sep-27, Volume: 16, Issue:5

    Topics: Acute Disease; Amidohydrolases; Animals; Arthralgia; Benzamides; Carbamates; Carrageenan; Endocannabinoids; Hindlimb; Hyperalgesia; Indoles; Inflammation; Kaolin; Knee Joint; Male; Mice, Inbred C57BL; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Synovitis; Weight-Bearing

2014
Cannabinoid type 1 and type 2 receptor antagonists prevent attenuation of serotonin-induced reflex apneas by dronabinol in Sprague-Dawley rats.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Animals; Cannabinoid Receptor Agonists; Dronabinol; Electromyography; Femoral Vein; Indoles; Male; Nodose Ganglion; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin; Sleep Apnea, Obstructive; Treatment Outcome

2014
Involvement of central and peripheral cannabinoid receptors on antinociceptive effect of tetrahydrocannabinol in muscle pain.
    European journal of pharmacology, 2014, Dec-15, Volume: 745

    Topics: Analgesics; Animals; Cannabinoid Receptor Agonists; Dronabinol; Indoles; Injections, Intramuscular; Injections, Intraperitoneal; Male; Masseter Muscle; Muscle, Skeletal; Myalgia; Piperidines; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid

2014
Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats.
    Nutrition (Burbank, Los Angeles County, Calif.), 2015, Volume: 31, Issue:1

    Topics: Animals; Eating; Endocannabinoids; Fasting; Ghrelin; Hyperphagia; Indoles; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2015
Antidepressant-like effects of the cannabinoid receptor ligands in the forced swimming test in mice: mechanism of action and possible interactions with cholinergic system.
    Behavioural brain research, 2015, May-01, Volume: 284

    Topics: Animals; Antidepressive Agents; Cannabinoids; Depressive Disorder; Disease Models, Animal; Indoles; Ligands; Male; Mice; Motor Activity; Nicotine; Oleic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Scopolamine; Swimming

2015
Cannabinoid receptor agonists modulate calcium channels in rat retinal Müller cells.
    Neuroscience, 2016, Jan-28, Volume: 313

    Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium; Calcium Channels; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cells, Cultured; Dose-Response Relationship, Drug; Endocannabinoids; Ependymoglial Cells; Glycerides; Indoles; Male; Membrane Potentials; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant

2016
Correlations between the Memory-Related Behavior and the Level of Oxidative Stress Biomarkers in the Mice Brain, Provoked by an Acute Administration of CB Receptor Ligands.
    Neural plasticity, 2016, Volume: 2016

    Topics: Animals; Avoidance Learning; Behavior, Animal; Benzoxazines; Biomarkers; Brain; Cannabinoids; Indoles; Male; Malondialdehyde; Memory; Mice; Morpholines; Naphthalenes; Oxidative Stress; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2016
Effects of cannabinoid receptor activation by CP55,940 on normal bladder function and irritation-induced bladder overactivity in non-awake anaesthetised rats.
    International urogynecology journal, 2016, Volume: 27, Issue:9

    Topics: Acetic Acid; Administration, Intravesical; Animals; Cannabinoid Receptor Agonists; Cyclohexanols; Disease Models, Animal; Female; Indoles; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Treatment Outcome; Urinary Bladder; Urinary Bladder, Overactive; Urination; Urodynamics

2016
Cannabinoid Receptors CB1 and CB2 Modulate the Electroretinographic Waves in Vervet Monkeys.
    Neural plasticity, 2016, Volume: 2016

    Topics: Animals; Chlorocebus aethiops; Electroretinography; Ependymoglial Cells; Indoles; Membrane Potentials; Photic Stimulation; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Retina; Retinal Neurons

2016
Capsaicin-Induced Death of Human Haematological Malignant Cell Lines Is Independent of TRPV1 Activation.
    Pharmacology, 2016, Volume: 98, Issue:1-2

    Topics: Cannabinoid Receptor Antagonists; Capsaicin; Cell Death; Cell Line, Tumor; Hematologic Neoplasms; Humans; Indoles; Oxazines; Piperidines; Pyrazoles; TRPV Cation Channels; Xanthenes

2016
Anandamide transporter-mediated regulation of the micturition reflex in urethane-anesthetized rats.
    International urology and nephrology, 2016, Volume: 48, Issue:9

    Topics: Administration, Intravenous; Anesthetics, Intravenous; Animals; Arachidonic Acids; Endocannabinoids; Female; Indoles; Membrane Transport Modulators; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex; Urethane; Urination; Urodynamics

2016
Behavioral evidence for the interaction between cannabinoids and Catha edulis F. (Khat) in mice.
    Brain research, 2016, 10-01, Volume: 1648, Issue:Pt A

    Topics: Animals; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Catha; Endocannabinoids; Indoles; Locomotion; Male; Memory, Short-Term; Mice; Morpholines; Naphthalenes; Piperidines; Plant Extracts; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2016
Anandamide reverses depressive-like behavior, neurochemical abnormalities and oxidative-stress parameters in streptozotocin-diabetic rats: Role of CB1 receptors.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2016, Volume: 26, Issue:10

    Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain Chemistry; Calcium Channel Blockers; Depression; Diabetes Mellitus, Experimental; Endocannabinoids; Indoles; Male; Norepinephrine; Oxidative Stress; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin; Swimming

2016
Inhibition of interleukin-1β-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2.
    Oncotarget, 2016, 09-20, Volume: 7, Issue:38

    Topics: Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Capsaicin; Cells, Cultured; Ceramides; Human Umbilical Vein Endothelial Cells; Humans; Indoles; Interleukin-1beta; JNK Mitogen-Activated Protein Kinases; Monocytes; Morpholines; Naphthalenes; p38 Mitogen-Activated Protein Kinases; Partial Thromboplastin Time; Phosphorylation; Piperidines; Pyrazoles; RNA, Messenger; Signal Transduction; Sphingomyelin Phosphodiesterase; Thromboplastin; TRPV Cation Channels

2016
Endocannabinoid mechanism for orofacial antinociception induced by electroacupuncture in acupoint St36 in rats.
    Pharmacological reports : PR, 2016, Volume: 68, Issue:6

    Topics: Acupuncture Points; Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroacupuncture; Endocannabinoids; Facial Pain; Indoles; Male; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Wistar

2016
Activation of cannabinoid receptors elicits antidepressant-like effects in a mouse model of social isolation stress.
    Brain research bulletin, 2017, Volume: 130

    Topics: Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Depression; Disease Models, Animal; Indoles; Male; Mice; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Social Isolation; Stress, Psychological

2017
Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.
    Neuropharmacology, 2017, Volume: 125

    Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents, Phytogenic; Cannabinoid Receptor Modulators; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Indoles; Male; Neuralgia; Paclitaxel; Pain Threshold; Peripheral Nervous System Diseases; Piperidines; Polycyclic Sesquiterpenes; Pyrazoles; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sesquiterpenes; Spinal Cord

2017
Effects of Cannabinoid Agonists and Antagonists on Sleep and Breathing in Sprague-Dawley Rats.
    Sleep, 2017, 09-01, Volume: 40, Issue:9

    Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dronabinol; Electroencephalography; Electromyography; Indoles; Male; Piperidines; Polysomnography; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Respiration; Sleep; Sleep Apnea, Central; Sleep, REM; Vagus Nerve

2017
Remote Ischemia Preconditioning Attenuates Blood-Spinal Cord Barrier Breakdown in Rats Undergoing Spinal Cord Ischemia Reperfusion Injury: Associated with Activation and Upregulation of CB1 and CB2 Receptors.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2017, Volume: 43, Issue:6

    Topics: Animals; Disease Models, Animal; Down-Regulation; Femoral Artery; Indoles; Ischemic Preconditioning; Male; Permeability; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reperfusion Injury; Spinal Cord; Up-Regulation

2017
Modulation of the endocannabinoid system by the fatty acid amide hydrolase, monoacylglycerol and diacylglycerol lipase inhibitors as an attractive target for secretory diarrhoea therapy.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2017, Volume: 68, Issue:4

    Topics: Amidohydrolases; Animals; Benzodioxoles; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cyclohexanones; Diarrhea; Endocannabinoids; Enzyme Inhibitors; Indoles; Lipoprotein Lipase; Male; Mice; Monoglycerides; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2017
Involvement of spinal cannabinoid receptors in the antipruritic effects of WIN 55,212-2, a cannabinoid receptor agonist.
    Clinical and experimental dermatology, 2018, Volume: 43, Issue:5

    Topics: Animals; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Indoles; Male; Mice; Mice, Inbred BALB C; Morpholines; Naphthalenes; Piperidines; Pruritus; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Serotonin; Spinal Cord

2018
Antinociceptive effects of the endogenous cannabinoid peptide agonist VD-hemopressin(β) in mice.
    Brain research bulletin, 2018, Volume: 139

    Topics: Acetic Acid; Analgesics; Animals; Area Under Curve; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Indoles; Male; Mice; Mice, Inbred Strains; Oligopeptides; Pain; Pain Measurement; Piperidines; Pyrazoles; Rotarod Performance Test; Spinal Cord

2018
Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:3

    Topics: Amidohydrolases; Analgesics, Opioid; Animals; Antineoplastic Agents; Arachidonic Acids; Benzamides; Brain; Cannabinoids; Carbamates; Gastrointestinal Transit; Hyperalgesia; Indoles; Mice; Mice, Inbred C57BL; Morphine; Morpholines; Neuralgia; Nociception; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2018
Cannabinoid CB
    Pharmacological reports : PR, 2019, Volume: 71, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Cannabinoid Receptor Antagonists; Drug Interactions; Heart Atria; Heart Rate; In Vitro Techniques; Indoles; Isoproterenol; Male; Myocardial Contraction; Piperidines; Pyrazoles; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Adrenergic, beta-1; Signal Transduction

2019
Hypothalamic endocannabinoid signalling modulates aversive responses related to panic attacks.
    Neuropharmacology, 2019, Volume: 148

    Topics: Animals; Arachidonic Acids; Benzamides; Biphenyl Compounds; Blood Pressure; Cannabinoids; Carbamates; Corticosterone; Dorsomedial Hypothalamic Nucleus; Endocannabinoids; Indoles; Male; Microinjections; N-Methylaspartate; Panic Disorder; Piperidines; Pyrazoles; Rats

2019
Ketamine induces central antinociception mediated by endogenous cannabinoids and activation of CB
    Neuroscience letters, 2019, 04-23, Volume: 699

    Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Drug Synergism; Indoles; Infusions, Intraventricular; Ketamine; Male; Mice; Organophosphonates; Pain Measurement; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2

2019
Cannabidiol inhibits sucrose self-administration by CB1 and CB2 receptor mechanisms in rodents.
    Addiction biology, 2020, Volume: 25, Issue:4

    Topics: Animals; Behavior, Animal; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Feeding Behavior; Indoles; Mice; Mice, Knockout; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Self Administration; Sucrose; Sweetening Agents

2020
CB
    The Journal of experimental biology, 2019, 09-02, Volume: 222, Issue:Pt 16

    Topics: Animals; Indoles; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Swimming; Zebrafish; Zebrafish Proteins

2019
Cannabinoid system involves in the analgesic effect of protocatechuic acid.
    Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2019, Volume: 27, Issue:2

    Topics: Acetic Acid; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hydroxybenzoates; Indoles; Male; Mice; Pain; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid

2019
Cannabinoid receptors and the proconvulsant effect of toxoplasmosis in mice.
    Microbial pathogenesis, 2020, Volume: 144

    Topics: Animals; Benzodioxoles; Cannabinoids; Disease Models, Animal; Indoles; Male; Mice; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Toxoplasma; Toxoplasmosis

2020
N‑linoleyltyrosine protects PC12 cells against oxidative damage via autophagy: Possible involvement of CB1 receptor regulation.
    International journal of molecular medicine, 2020, Volume: 46, Issue:5

    Topics: Adenine; Animals; Arachidonic Acids; Autophagy; Cell Survival; Endocannabinoids; Hydrogen Peroxide; Indoles; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tyrosine

2020
Functional Crosstalk between CB and TRPV1 Receptors Protects Nigrostriatal Dopaminergic Neurons in the MPTP Model of Parkinson's Disease.
    Journal of immunology research, 2020, Volume: 2020

    Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Capsaicin; Disease Models, Animal; Dopaminergic Neurons; Humans; Indoles; Mice; Mice, Inbred C57BL; Neurogenic Inflammation; Neuroglia; Neuroprotection; Parkinson Disease; Piperidines; Pyrazoles; Receptor Cross-Talk; Receptors, Cannabinoid; Substantia Nigra; TRPV Cation Channels

2020
Allosteric modulation of the cannabinoid 2 receptor confers seizure resistance in mice.
    Neuropharmacology, 2021, 05-01, Volume: 188

    Topics: Allosteric Regulation; Animals; Benzeneacetamides; Cannabinoids; Indoles; Male; Mice; Mice, Transgenic; Piperidines; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Seizures

2021
The ω-3 endocannabinoid docosahexaenoyl ethanolamide reduces seizure susceptibility in mice by activating cannabinoid type 1 receptors.
    Brain research bulletin, 2021, Volume: 170

    Topics: Animals; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Docosahexaenoic Acids; Fatty Acids, Omega-3; Indoles; Male; Mice; Pentylenetetrazole; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures

2021
Inhibitory effect of intrathecally administered AM404, an endocannabinoid reuptake inhibitor, on neuropathic pain in a rat chronic constriction injury model.
    Pharmacological reports : PR, 2021, Volume: 73, Issue:3

    Topics: Animals; Arachidonic Acids; Capsaicin; Constriction; Disease Models, Animal; Endocannabinoids; Hyperalgesia; Indoles; Male; Neuralgia; Pain Measurement; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rotarod Performance Test; Spinal Cord; TRPV Cation Channels

2021
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