altretamine and melphalan

altretamine has been researched along with melphalan in 42 studies

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-199032 (76.19)18.7374
1990's3 (7.14)18.2507
2000's4 (9.52)29.6817
2010's3 (7.14)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M1
Benfenati, E; Raska, I; Toropov, AA; Toropova, AP1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Anderson, T; Bender, RA; Canellos, GP; Chabner, BA; DeVita, VT; Fisher, RI; Hubbard, SP; Simon, RM; Young, RC1
Neijt, JP; Pinedo, HM; Roozendaal, KJ; Struyvenberg, A; van Lindert, AC; Vendrik, CP1
Costa, J; Garvin, AJ; Ozols, RF; Simon, RM; Young, RC1
Fisher, RI; Young, RC1
Rutledge, F; Smith, JP; Stanhope, CR1
Fraumeni, JF; Hoover, R; Reimer, RR; Young, RC1
Bruntsch, U; Gallmeier, WM1
Blessing, J; Lewis, GC1
Barber, HR; Buterman, I; Kakarla, R; Kwon, T1
Rutledge, FN; Smith, JP2
Canellos, GP; Chabner, BA; DeVita, VT; Hubbard, SP; Young, RC1
Venesmaa, P; Ylikorkala, O1
Brady, MF; Buchsbaum, HJ; Homesley, HD; Major, FJ; Omura, GA; Park, RC; Yordan, E1
Herbst, AL; Podczaski, E; Richman, CM; Weiser, PA1
Brown, LB; Carmichael, JA; Fraser, RC; Kirk, ME; Krepart, GV; Levitt, M; Pater, JL; Roy, M; Shelley, WE; Wilson, KS1
Brunner, KW; Dreher, E; Engeler, V; Forni, M; Goldhirsch, A; Greiner, R; Jungi, FW; Krauer, F; Sessa, C; Veraguth, P1
Carmichael, JA; Ross, WM; Shelley, WE1
Delgado, G; McLaughlin, EK; Smith, FP; Tuholski, N1
Brunner, KW; Davis, BW; Dreher, E; Goldhirsch, A; Greiner, R; Joss, R; Locher, G; Reinhard, JP1
Durie, BG; Salmon, SE1
Courtenay, VD; Mills, J; Steel, GG1
Honetz, N1
Bross, DS; Ettinger, DS; Hernandez, E; Klein, JL; Leichner, PK; Order, SE; Pino y Torres, JL; Rosenshein, N1
Brunner, KW; Burki, K; Davis, BW; Dreher, E; Goldhirsch, A; Greiner, R; Locher, GW1
Blessing, JA; Buchsbaum, HJ; Homesley, HD; Leone, L; Miller, A; Morrow, CP; Omura, GA1
Copeland, LJ; Edwards, CL; Gershenson, DM; Herson, J; Wharton, JT1
Dreher, E; Goldhirsch, A; Greiner, R; Herrmann, U; Locher, G1
Maggino, T; Onnis, A1
Klein-Angerer, S; Kohorn, EI1
Dembo, AJ1
Ozols, RF; Young, RC1
Davis, TE; Gilchrist, KW; Neville, AJ1
Kessinger, A; Tempero, MA1
Carbone, P; Vogl, S; Wadler, S; Yeap, B1
Antipenkova, VI; Gershanovich, ML; Livshits, ME1

Reviews

5 review(s) available for altretamine and melphalan

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
The current status and future prospects of treatment for multiple myeloma.
    Clinics in haematology, 1982, Volume: 11, Issue:1

    Topics: Acute Kidney Injury; Altretamine; Anemia; Bacterial Infections; Bone Neoplasms; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Humans; Hypercalcemia; Interferons; Kidney Failure, Chronic; Melphalan; Meningeal Neoplasms; Multiple Myeloma; Spinal Cord Compression; Vinblastine; Vincristine; Vindesine

1982
[Progress in the chemotherapy of ovarian cancer].
    Wiener medizinische Wochenschrift (1946), 1982, Jul-31, Volume: 132, Issue:13-14

    Topics: Adenocarcinoma, Mucinous; Altretamine; Antineoplastic Agents; Carcinoma, Squamous Cell; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Melphalan; Neoplasm Staging; Ovarian Neoplasms; Prognosis

1982
Radiotherapeutic management of ovarian cancer.
    Seminars in oncology, 1984, Volume: 11, Issue:3

    Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Leukemia; Melphalan; Ovarian Neoplasms

1984
Chemotherapy of ovarian cancer.
    Seminars in oncology, 1984, Volume: 11, Issue:3

    Topics: Altretamine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Estrogen Antagonists; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Ovarian Neoplasms; Progestins; Tamoxifen

1984

Trials

17 trial(s) available for altretamine and melphalan

ArticleYear
Advanced ovarian adenocarcinoma. A prospective clinical trial of melphalan (L-PAM) versus combination chemotherapy.
    The New England journal of medicine, 1978, Dec-07, Volume: 299, Issue:23

    Topics: Adenocarcinoma; Adult; Aged; Altretamine; Antineoplastic Agents; Cyclophosphamide; Drug Administration Schedule; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Middle Aged; Ovarian Neoplasms; Prospective Studies

1978
Hexa-CAF combination chemotherapy and other multiple-drug regimens in advanced ovarian carcinoma: present and future.
    The Netherlands journal of medicine, 1979, Volume: 22, Issue:2

    Topics: Altretamine; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Melphalan; Middle Aged; Ovarian Neoplasms; Triazines

1979
Histologic grade in advanced ovarian cancer.
    Cancer treatment reports, 1979, Volume: 63, Issue:2

    Topics: Altretamine; Cell Differentiation; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Methotrexate; Ovarian Neoplasms; Prognosis

1979
Advances in the staging and treatment of ovarian cancer.
    Cancer, 1977, Volume: 39, Issue:2 Suppl

    Topics: Alkylating Agents; Altretamine; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Laparoscopy; Lymphatic Metastasis; Lymphography; Melphalan; Neoplasm Metastasis; Ovarian Neoplasms

1977
Second trial drugs in ovarian cancer.
    Gynecologic oncology, 1977, Volume: 5, Issue:1

    Topics: Altretamine; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Ovarian Neoplasms; Thiotepa

1977
Ovarian cancer: use of multiple modality programs involving surgery, radiation therapy and chemotherapy.
    Cancer, 1977, Volume: 40, Issue:1 Suppl

    Topics: Altretamine; Antineoplastic Agents; Clinical Trials as Topic; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Immunotherapy; Melphalan; Ovarian Neoplasms; Propionibacterium acnes; Radiotherapy Dosage

1977
Preliminary Results of trials of chemotherapy in advanced ovarian carcinoma.
    National Cancer Institute monograph, 1975, Volume: 42

    Topics: Altretamine; Antineoplastic Agents; Clinical Trials as Topic; Cyclophosphamide; Drug Therapy, Combination; Female; Fluorouracil; Humans; Maryland; Melphalan; Methotrexate; National Institutes of Health (U.S.); Ovarian Neoplasms; Prospective Studies; United States

1975
Random study of hexamethylmelamine, 5-fluorouracil, and melphalan in treatment of advanced carcinoma of the ovary.
    National Cancer Institute monograph, 1975, Volume: 42

    Topics: Adult; Altretamine; Antineoplastic Agents; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Ovarian Neoplasms

1975
Subrenal capsule assay in selection of chemotherapy after operation for recurrent ovarian cancer.
    British journal of cancer, 1991, Volume: 63, Issue:1

    Topics: Adult; Aged; Altretamine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Cystadenocarcinoma; Doxorubicin; Drug Screening Assays, Antitumor; Epirubicin; Female; Follow-Up Studies; Humans; Melphalan; Mice; Middle Aged; Ovarian Neoplasms; Subrenal Capsule Assay

1991
Long-term follow-up and prognostic factor analysis in advanced ovarian carcinoma: the Gynecologic Oncology Group experience.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1991, Volume: 9, Issue:7

    Topics: Adult; Aged; Altretamine; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Humans; Melphalan; Middle Aged; Ovarian Neoplasms; Prognosis; Regression Analysis; Reoperation; Survival Rate

1991
Second-line chemotherapy of stage III-IV ovarian carcinoma: a randomized comparison of melphalan to melphalan and hexamethylmelamine in patients with persistent disease after doxorubicin and cisplatin.
    Cancer treatment reports, 1987, Volume: 71, Issue:3

    Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Doxorubicin; Female; Humans; Melphalan; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Random Allocation; Statistics as Topic

1987
Treatment of advanced ovarian cancer with surgery, chemotherapy, and consolidation of response by whole-abdominal radiotherapy.
    Cancer, 1988, Jul-01, Volume: 62, Issue:1

    Topics: Abdomen; Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Female; Humans; Melphalan; Middle Aged; Ovarian Neoplasms; Radiotherapy

1988
Multimodality treatment of patients with advanced ovarian carcinoma.
    International journal of radiation oncology, biology, physics, 1982, Volume: 8, Issue:10

    Topics: Adenocarcinoma, Mucinous; Altretamine; Antibodies, Neoplasm; Carcinoma; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Melphalan; Ovarian Neoplasms; Ovary; Phosphorus Radioisotopes; Prospective Studies; Random Allocation

1982
A randomized comparison of melphalan versus melphalan plus hexamethylmelamine versus adriamycin plus cyclophosphamide in ovarian carcinoma.
    Cancer, 1983, Mar-01, Volume: 51, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Altretamine; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Prognosis; Random Allocation; Triazines

1983
A prospective randomized clinical trial of melphalan and cis-platinum versus hexamethylmelamine, adriamycin, and cyclophosphamide in advanced ovarian cancer.
    Gynecologic oncology, 1983, Volume: 15, Issue:2

    Topics: Adult; Altretamine; Anemia; Antineoplastic Agents; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Humans; Leukopenia; Melphalan; Middle Aged; Ovarian Neoplasms; Prospective Studies; Random Allocation; Thrombocytopenia

1983
Radiotherapeutic management of ovarian cancer.
    Seminars in oncology, 1984, Volume: 11, Issue:3

    Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Leukemia; Melphalan; Ovarian Neoplasms

1984
Randomized trial of initial therapy with melphalan versus cisplatin-based combination chemotherapy in patients with advanced ovarian carcinoma: initial and long term results--Eastern Cooperative Oncology Group Study E2878.
    Cancer, 1996, Feb-15, Volume: 77, Issue:4

    Topics: Adult; Aged; Altretamine; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Cisplatin; Cross-Over Studies; Cyclophosphamide; Disease-Free Survival; Doxorubicin; Female; Follow-Up Studies; Humans; Melphalan; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Survival Rate; Time Factors

1996

Other Studies

21 other study(ies) available for altretamine and melphalan

ArticleYear
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling.
    Current drug discovery technologies, 2004, Volume: 1, Issue:4

    Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration

2004
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship

2008
QSPR modeling of octanol/water partition coefficient of antineoplastic agents by balance of correlations.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:4

    Topics: Antineoplastic Agents; Models, Chemical; Octanols; Quantitative Structure-Activity Relationship; Water

2010
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
    Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship

2012
Acute leukemia after alkylating-agent therapy of ovarian cancer.
    The New England journal of medicine, 1977, Jul-28, Volume: 297, Issue:4

    Topics: Acute Disease; Alkylating Agents; Altretamine; Chlorambucil; Cyclophosphamide; Female; Fluorouracil; Humans; Leukemia; Leukemia, Erythroblastic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Melphalan; Middle Aged; Neoplasm Metastasis; Ovarian Neoplasms; Risk; Thiotepa; Time Factors; Uracil Mustard

1977
[Chemotherapy of the ovarian carcinoma (author's transl)].
    Strahlentherapie, 1977, Volume: 153, Issue:5

    Topics: Altretamine; Antineoplastic Agents; Chlorambucil; Cisplatin; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Hydroxyprogesterones; Mechlorethamine; Melphalan; Mercaptopurine; Methotrexate; Mitomycins; Nitrosourea Compounds; Ovarian Neoplasms; Thiotepa; Vinblastine; Vincristine

1977
Current concepts in the management of ovarian cancer.
    The Journal of reproductive medicine, 1978, Volume: 20, Issue:1

    Topics: Adult; Aged; Altretamine; Castration; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Melphalan; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; United States

1978
Chemotherapy in advanced ovarian cancer.
    National Cancer Institute monograph, 1975, Volume: 42

    Topics: Altretamine; Antineoplastic Agents; Cyclophosphamide; Dactinomycin; Doxorubicin; Drug Therapy, Combination; Female; Fluorouracil; Humans; Melphalan; Ovarian Neoplasms

1975
Hexamethylmelamine, cyclophosphamide, adriamycin, cis-platinum chemotherapy as initial and second-line treatment of advanced ovarian carcinoma.
    Oncology, 1986, Volume: 43, Issue:1

    Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cyclophosphamide; Doxorubicin; Female; Follow-Up Studies; Humans; Melphalan; Middle Aged; Ovarian Neoplasms; Reoperation

1986
Advanced carcinoma of the ovary with central nervous system relapse.
    Gynecologic oncology, 1988, Volume: 30, Issue:3

    Topics: Adenocarcinoma; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Combined Modality Therapy; Doxorubicin; Female; Humans; Melphalan; Meningeal Neoplasms; Middle Aged; Ovarian Neoplasms

1988
Single agent vs. combination chemotherapy for ovarian cancer.
    American journal of clinical oncology, 1985, Volume: 8, Issue:1

    Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Cyclophosphamide; Female; Fluorouracil; Humans; Melphalan; Ovarian Neoplasms; Random Allocation; Time Factors

1985
The treatment of ovarian cancer by a multimodality approach: remission induction with chemotherapy--hexa PAMP and PAMP regimens--followed by whole-abdominal radiation.
    Onkologie, 1985, Volume: 8, Issue:6

    Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Humans; Melphalan; Middle Aged; Ovarian Neoplasms; Prognosis

1985
The spectrum of chemosensitivity of two human pancreatic carcinoma xenografts.
    British journal of cancer, 1982, Volume: 46, Issue:3

    Topics: Altretamine; Animals; Antineoplastic Agents; Cell Line; Cisplatin; Cyclophosphamide; Hindlimb; Humans; Melphalan; Mice; Mice, Inbred CBA; Neoplasm Transplantation; Pancreatic Neoplasms; Semustine; Streptozocin; Transplantation, Heterologous; Vinblastine

1982
Pathologic data of prognostic significance for remission induction in advanced ovarian carcinoma.
    Journal of cancer research and clinical oncology, 1984, Volume: 107, Issue:2

    Topics: Adenocarcinoma; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Evaluation; Female; Humans; Melphalan; Middle Aged; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Prognosis; Reoperation

1984
[New therapeutic concept for advanced ovarian cancer (FIGO IIb+c, III, IV)].
    Gynakologische Rundschau, 1983, Volume: 22 Suppl 3

    Topics: Adult; Aged; Altretamine; Cisplatin; Female; Humans; Melphalan; Middle Aged; Neoplasm Staging; Ovarian Neoplasms

1983
Repetitive debulking surgery as adjuvant to chemotherapy in advanced epithelial ovarian cancer.
    Clinical and experimental obstetrics & gynecology, 1984, Volume: 11, Issue:1-2

    Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Humans; Melphalan; Ovarian Neoplasms; Prospective Studies; Reoperation

1984
The effect of chemotherapy on lymphocyte subpopulations and cell-mediated cytotoxicity in patients with ovarian carcinoma.
    Gynecologic oncology, 1984, Volume: 19, Issue:1

    Topics: Altretamine; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Cyclophosphamide; Cytotoxicity Tests, Immunologic; Cytotoxicity, Immunologic; Doxorubicin; Female; Humans; Leukocyte Count; Lymphocytes; Melphalan; Ovarian Neoplasms; T-Lymphocytes; Time Factors

1984
The chemotherapy of granulosa cell tumors of the ovary: experience of the Wisconsin Clinical Cancer Center.
    Medical and pediatric oncology, 1984, Volume: 12, Issue:6

    Topics: Adult; Aged; Altretamine; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cyclophosphamide; Doxorubicin; Female; Fluorouracil; Granulosa Cell Tumor; Humans; Melphalan; Methotrexate; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Prednisone; Retrospective Studies; Vincristine

1984
Hexamethylmelamine and melphalan as salvage therapy in advanced ovarian carcinoma.
    Journal of surgical oncology, 1982, Volume: 21, Issue:3

    Topics: Adenocarcinoma, Papillary; Aged; Altretamine; Drug Therapy, Combination; Female; Humans; Melphalan; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Ovarian Neoplasms; Triazines

1982
[Combination chemotherapy with hexamethylamine (Hexalen, Altretamine, Hexastat) and sarcolysine in advanced ovarian carcinoma].
    Voprosy onkologii, 2000, Volume: 46, Issue:5

    Topics: Adult; Aged; Altretamine; Antineoplastic Agents, Alkylating; Carcinoma; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Humans; Melphalan; Middle Aged; Ovarian Neoplasms; Retrospective Studies; Treatment Outcome

2000