altenusin and dehydroaltenusin

altenusin has been researched along with dehydroaltenusin* in 1 studies

Other Studies

1 other study(ies) available for altenusin and dehydroaltenusin

Article	Year
Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur. Bioscience, biotechnology, and biochemistry, 1995, Volume: 59, Issue:7 Dehydroaltenusin, cyclooctasulfur, atrovenetinone, and altenusin were isolated from the culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticillus subsp. tskushiensis ATCC-21633, Penicillium sp. SPC-16375, and Penicillium sp. SPC-16524, respectively, as new myosin light chain kinase (MLCK) inhibitors. These compounds inhibited the calmodulin-dependent activity of MLCK with IC50 values of 0.69, 0.86, 3.7, and 350 microM, respectively. Among them, dehydroaltenusin was the best MLCK inhibitor in terms of potency and selectivity examined in the purified enzyme systems. Topics: Benzopyrans; Biphenyl Compounds; Calmodulin; Histamine Antagonists; Hydrolysis; Myosin-Light-Chain Kinase; Naphthalenes; Penicillium; Streptomyces; Sulfur; Trypsin	1995

Article

Year

Isolation of myosin light chain kinase inhibitors from microorganisms: dehydroaltenusin, altenusin, atrovenetinone, and cyclooctasulfur.

Bioscience, biotechnology, and biochemistry, 1995, Volume: 59, Issue:7

Dehydroaltenusin, cyclooctasulfur, atrovenetinone, and altenusin were isolated from the culture broths of Penicillium verruculosum IAM-13756, Streptomyces verticillus subsp. tskushiensis ATCC-21633, Penicillium sp. SPC-16375, and Penicillium sp. SPC-16524, respectively, as new myosin light chain kinase (MLCK) inhibitors. These compounds inhibited the calmodulin-dependent activity of MLCK with IC50 values of 0.69, 0.86, 3.7, and 350 microM, respectively. Among them, dehydroaltenusin was the best MLCK inhibitor in terms of potency and selectivity examined in the purified enzyme systems.

Topics: Benzopyrans; Biphenyl Compounds; Calmodulin; Histamine Antagonists; Hydrolysis; Myosin-Light-Chain Kinase; Naphthalenes; Penicillium; Streptomyces; Sulfur; Trypsin

1995