alstonerine and sarpagine

alstonerine has been researched along with sarpagine* in 2 studies

Other Studies

2 other study(ies) available for alstonerine and sarpagine

ArticleYear
Oxidized derivatives of macroline, sarpagine, and pleiocarpamine alkaloids from Alstonia angustifolia.
    Journal of natural products, 2014, Sep-26, Volume: 77, Issue:9

    A total of 20 new indole alkaloids comprising mainly oxidized derivatives of macroline- (including alstofonidine, a macroline indole incorporating a butyrolactone ring-F), pleiocarpamine-, and sarpagine-type alkaloids were isolated from the bark and leaf extracts of Alstonia angustifolia. The structures and relative configurations of these alkaloids were determined using NMR and MS analyses and in some instances confirmed by X-ray diffraction analyses. Alkaloids 3, 7, 35, and 41 showed moderate to weak activity, while 21 showed strong activity in reversing multidrug resistance in vincristine-resistant KB cells.

    Topics: Alkaloids; Alstonia; Crystallography, X-Ray; Humans; Indole Alkaloids; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Oxindoles; Plant Leaves; Vincristine

2014
Vasorelaxant activity of indole alkaloids from Tabernaemontana dichotoma.
    Journal of natural medicines, 2013, Volume: 67, Issue:1

    The aim of this study was to search for bioactive natural products from medicinal plants targeting vasorelaxant activity and we found the methanol extract from bark of Tabernaemontana dichotoma showed vasorelaxant activity on rat aorta. We isolated eight indole alkaloids including 10-methoxyalstonerine (1), a new macroline type indole alkaloid, from bark of T. dichotoma. These were respectively identified as 10-methoxyaffinisine (2), lochnerine (3), cathafoline (4), (-)-alstonerine (5), 19,20-dehydro-10-methoxytalcarpine (6), alstonisine (7), and alstonal (8) based on spectroscopic analysis. Among them, sarpagine type (2 and 3), akuammiline type (4), and macroline oxindole type (7 and 8) showed potent vasorelaxant activity. Mechanism of action on vasorelaxant activity of 10-methoxyaffinisine (2), cathafoline (4), and alstonisine (7) was clarified. Effects of 10-methoxyaffinisine (2), cathafoline (4), and alstonisine (7) were partially mediated the NO release from endothelial cells. Furthermore, 10-methoxyaffinisine (2) and alstonisine (7) attribute to the inhibitory effect of VDC and ROC, and cathafoline (4) have inhibitory effect on Ca(2+) influx via ROC. In addition, 10-methoxyaffinisine (2) as a major compound from bark of T. dichotoma showed hypotensive effect on normotensive rats in vivo.

    Topics: Animals; Blood Pressure; Indole Alkaloids; Indoles; Male; Molecular Structure; Oxindoles; Rats; Rats, Wistar; Spiro Compounds; Tabernaemontana; Vasodilator Agents

2013