alsterpaullone has been researched along with paullone* in 1 studies
1 other study(ies) available for alsterpaullone and paullone
| Article | Year |
|---|---|
Development of 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters as selective inhibitors of mitochondrial malate dehydrogenase (mMDH).
A collection of paullones was tested for inhibitory activity against mitochondrial malate dehydrogenase (mMDH) as a biological target for antiproliferative activity. Based on the results of this screening, 5-benzylpaullones and paullone-9-carboxylic acid alkyl esters were developed as selective mMDH inhibitors. The new derivatives did not show noteworthy antiproliferative activity when tested on a panel of cancer cell lines, suggesting that mMDH inhibition is of minor relevance for the growth inhibition caused by paullones. Topics: Benzazepines; Carboxylic Acids; Cell Line, Tumor; Drug Discovery; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Malate Dehydrogenase; Mitochondria; Substrate Specificity | 2010 |